phosphotyrosine has been researched along with wortmannin in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 51 (73.91) | 18.2507 |
| 2000's | 17 (24.64) | 29.6817 |
| 2010's | 1 (1.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Fukui, Y; Hazeki, K; Hazeki, O; Ninomiya, N; Okada, T; Seya, T; Ui, M | 1 |
| Anderson, NG; Kilgour, E | 1 |
| Parry, R; Sansom, D; Ward, S; Westwick, J; Wilson, A | 1 |
| Bierer, BE; Franklin, DP; Harrison-Findik, D; Hutchcroft, JE; Tsai, B; Varticovski, L | 1 |
| Cantley, LC; Chen, CS; Rameh, LE | 1 |
| Farndale, RW; Jenner, S; Sage, SO | 1 |
| Hazeki, K; Hazeki, O; Katada, T; Matsuo, T; Ui, M | 1 |
| Anderson, NG; Gout, I; Kilgour, E | 1 |
| Hoffman, BB; Hu, ZW; Lin, RZ; Shi, XY | 1 |
| Bowser, JM; Cohen, ME; Donowitz, M; Khurana, S; Levine, SA; Nath, SK; Tse, CM | 1 |
| Claesson-Welsh, L; Hooshmand-Rad, R; Rankin, S; Rozengurt, E | 1 |
| Bjorndahl, J; Lu, Y; Phillips, CA; Rodriguez, R; Trevillyan, JM | 1 |
| Goldstein, BJ; Li, PM | 1 |
| Duronio, V; Ettinger, SL; Lauener, RW | 1 |
| Henquin, JC; Jonas, JC | 1 |
| Le Marchand-Brustel, Y; Ricort, JM; Tanti, JF; Van Obberghen, E | 1 |
| Luo, Z; Mei, L; Si, J | 1 |
| Haigh, RJ; Hayward, AC; Navé, BT; Shepherd, PR; Siddle, K | 1 |
| Navé, BT; Shepherd, PR; Siddle, K | 1 |
| Chap, H; Cossart, P; Ireton, K; Kasuga, M; Ogawa, W; Payrastre, B; Sakaue, H | 1 |
| Calera, MR; Farmer, SR; Milasincic, DJ; Pilch, PF | 1 |
| Klippel, A; Martin, SS; Olefsky, JM; Rose, DW; Saltiel, AR; Williams, LT | 1 |
| Chew, CS; Nakamura, K; Parente, J; Zhou, CJ | 1 |
| Akhtar, RA; Zhang, Y | 1 |
| Bos, JL; van Weering, DH | 1 |
| Butler, J; Downey, GP; Fialkow, L; Grinstein, S; Schelm, JA; Sue-A-Quan, AK; Vlahos, CJ | 1 |
| Exley, M; Varticovski, L | 1 |
| Kowalski-Chauvel, A; Pradayrol, L; Seva, C; Vaysse, N | 1 |
| Aizawa, S; Akanuma, Y; Cushman, SW; Kaburagi, Y; Kadowaki, T; Kono-Sugita, E; Satoh, S; Sekihara, H; Tamemoto, H; Tobe, K; Veki, K; Yamamoto-Honda, R; Yamauchi, T; Yazaki, Y | 1 |
| Chen, D; Earp, HS; Elmendorf, JS; Li, X; Olson, AL; Pessin, JE | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Hirai, H; Honda, H; Mitani, K; Miyagawa, K; Nakamoto, T; Sasaki, K; Ueno, H; Yamagata, T; Yazaki, Y | 1 |
| Barker, SA; Caldwell, KK; Pfeiffer, JR; Wilson, BS | 1 |
| Jackson, JG; White, MF; Yee, D | 1 |
| Brunskill, NJ; Nahorski, S; Stuart, J; Tobin, AB; Walls, J | 1 |
| Bourbonais, FJ; Brady, MJ; Saltiel, AR | 1 |
| Avruch, J; Belham, C; Hara, K; Kozlowski, MT; Weng, QP; Yonezawa, K | 1 |
| Cheng, HL; Feldman, EL | 1 |
| Begum, N; Ragolia, L; Rienzie, J; Song, Y | 1 |
| Imai, K; Kojima, N; Matano, Y; Miura, M; Sato, M; Senoo, H | 1 |
| Damen, JE; Helgason, CD; Huber, M; Humphries, RK; Krystal, G; Liu, L | 1 |
| Domin, J; Turner, SJ; Ward, SG; Waterfield, MD; Westwick, J | 1 |
| Casamassima, A; Rozengurt, E | 1 |
| Cheng, HL; Feldman, EL; Kim, B; Margolis, B | 1 |
| Baeuerle, PA; Béraud, C; Henzel, WJ | 1 |
| Bussolino, F; Defilippi, P; Mitola, S; Soldi, R; Strasly, M; Tarone, G | 1 |
| Arcaro, A; Bottomley, MJ; Driscoll, PC; Gaffney, PR; Panayotou, G; Potter, BV; Riley, AM; Sankar, A; Siegal, G; Surdo, PL; Waterfield, MD | 1 |
| Sagi-Eisenberg, R; Seger, R; Shefler, I | 1 |
| Fisher, SK; Linseman, DA; Sorensen, SD | 1 |
| Boxer, LA; Hinkovska-Galcheva, V; Mansfield, PJ; Raeder, EM; Shayman, JA | 1 |
| Fathallah, H; Giraud, F; Mazière, P; Sauvage, M | 1 |
| Araki, Y; Sendo, F; Yu, Y | 1 |
| Heads, RJ; Marber, MS; Mockridge, JW | 1 |
| de Castro, SL; Einicker-Lamas, M; Guilherme, A; Oliveira, MM; Todorov, AG | 1 |
| Clague, MJ; Kitamura, N; Mills, IG; Stenmark, H; Urbé, S | 1 |
| Berg, LJ; Ching, KA; Tsoukas, CD; Yang, WC | 1 |
| Felix, R; Palacio, S | 1 |
| Bruyninckx, WJ; Colgan, SP; Comerford, KM; Lawrence, DW | 1 |
| Akanuma, Y; Ito, T; Kaburagi, Y; Kadowaki, T; Kimura, S; Satoh, S; Sekihara, H; Ueki, K; Yamamoto-Honda, R | 1 |
| Oda, A; Taniguchi, T; Yokoyama, M | 1 |
| Backer, JM; Collinson, LM; Futter, CE; Hopkins, CR | 1 |
| Hiller, G; Sundler, R | 1 |
| Arias, IM; Kagawa, T; Sai, Y; Varticovski, L | 1 |
| Backer, JM; Kempiak, SJ; Segall, JE; Yip, SC | 1 |
| Schwarz, H; Shaqireen D O Kwajah, MM; Söllner, L; Wu, JT | 1 |
| Agelaki, S; Georgoulias, V; Kallergi, G; Markomanolaki, H; Stournaras, C | 1 |
| Engel, P; Martin, M; Martinez-Barriocanal, A; Oliver-Vila, I; Saborit-Villarroya, I; Sayos, J | 1 |
| Benn, A; Boergermann, JH; Denkis, A; Hiepen, C; Knaus, P; Lukonin, I; Weise, C | 1 |
69 other study(ies) available for phosphotyrosine and wortmannin
| Article | Year |
|---|---|
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.
Topics: Androstadienes; Animals; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Macromolecular Substances; Neutrophils; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphopeptides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1994 |
Differential effects of wortmannin on growth hormone dependent signalling pathways in 3T3-F442A cells.
Topics: 3T3 Cells; Androstadienes; Animals; Culture Media, Serum-Free; Growth Hormone; Insulin Antagonists; Kinetics; Mice; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine; Wortmannin | 1995 |
The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.
Topics: Androstadienes; Animals; CD28 Antigens; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Lymphocyte Activation; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1995 |
Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
Topics: Androstadienes; CD28 Antigens; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-2; Leukemia, T-Cell; Lymphocyte Activation; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Protein Binding; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Topics: Amino Acid Sequence; Androstadienes; Animals; Binding, Competitive; CHO Cells; Chromones; Cricetinae; Enzyme Inhibitors; Humans; Insulin; Molecular Sequence Data; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptor, Insulin; src Homology Domains; Transfection; Wortmannin | 1995 |
Wortmannin inhibits store-mediated calcium entry and protein tyrosine phosphorylation in human platelets.
Topics: Androstadienes; Blood Platelets; Blood Proteins; Calcium; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Kinetics; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Terpenes; Thapsigargin; Wortmannin | 1996 |
Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocyti
Topics: Amino Acid Sequence; Androstadienes; Cell Line; Concanavalin A; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Monocytes; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Respiratory Burst; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1996 |
Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways.
Topics: 3T3 Cells; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Growth Hormone; Insulin Receptor Substrate Proteins; Janus Kinase 2; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Wortmannin | 1996 |
Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; DNA; Enzyme Activation; Enzyme Inhibitors; Humans; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Adrenergic, alpha; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1996 |
Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange.
Topics: Androstadienes; Animals; Cell Line; Cell Polarity; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Glucose; Humans; Intestinal Absorption; Intestinal Mucosa; Isoflavones; Microvilli; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Sodium Chloride; Sodium-Hydrogen Exchangers; Transfection; Wortmannin | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
CD28-dependent killing by human YT cells requires phosphatidylinositol 3-kinase activation.
Topics: Amino Acid Sequence; Androstadienes; Benzoquinones; Calcium; CD28 Antigens; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Immunity, Cellular; Lactams, Macrocyclic; Leukemia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Quinones; Rifabutin; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Wortmannin | 1996 |
Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells.
Topics: Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation.
Topics: Androstadienes; Animals; Blood Platelets; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Isoenzymes; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Activating Factor; Protein Binding; Protein Kinase C; Protein Kinase C-delta; Rabbits; Rats; Receptors, IgE; Recombinant Proteins; Tumor Cells, Cultured; Wortmannin | 1996 |
Possible involvement of a tyrosine kinase-dependent pathway in the regulation of phosphoinositide metabolism by vanadate in normal mouse islets.
Topics: Acetylcholine; Androstadienes; Animals; Arginine Vasopressin; Calcium; Cattle; Enzyme Inhibitors; Female; GTP-Binding Proteins; Islets of Langerhans; Mice; Mice, Inbred Strains; Phosphatidylinositols; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Stimulation, Chemical; Tungsten Compounds; Type C Phospholipases; Vanadates; Wortmannin | 1996 |
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinase.
Topics: Androstadienes; Animals; Avian Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Muscle, Skeletal; Nerve Tissue Proteins; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, ErbB-2; Receptors, Nicotinic; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 1996 |
Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; Cell Membrane; Deoxyglucose; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Transferrin; src Homology Domains; Subcellular Fractions; Wortmannin | 1996 |
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Blotting, Western; Chromones; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
A role for phosphoinositide 3-kinase in bacterial invasion.
Topics: Androstadienes; Animals; Bacterial Proteins; Cell Line; Chromones; Cytochalasin D; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Listeria monocytogenes; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Tumor Cells, Cultured; Wortmannin | 1996 |
Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; DNA; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Kinetics; Mice; Mitogen-Activated Protein Kinase Kinases; Muscle, Skeletal; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase Inhibitors; Recombinant Proteins; Signal Transduction; Wortmannin | 1996 |
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
Topics: Actins; Androstadienes; Animals; Cell Division; Cell Line; Cytoskeleton; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Transfection; Wortmannin | 1996 |
Parietal cell MAP kinases: multiple activation pathways.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cyclic AMP; Cytosol; Enzyme Activation; Epidermal Growth Factor; Gastric Mucosa; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parasympathomimetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Effect of epidermal growth factor on phosphatidylinositol 3-kinase activity in rabbit corneal epithelial cells.
Topics: Androstadienes; Animals; Cells, Cultured; Cornea; Epidermal Growth Factor; Epithelium; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polyethylene Glycols; Rabbits; Wortmannin | 1996 |
Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation.
Topics: Actin Cytoskeleton; Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Mitogen-Activated Protein Kinase 1; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1997 |
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Topics: Androstadienes; Antigens, CD; Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Degranulation; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Tetraspanin 30; Wortmannin | 1997 |
Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction.
Topics: Androstadienes; Cell Line; Enzyme Inhibitors; Humans; Lymphocyte Activation; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; Wortmannin | 1997 |
Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Gastrins; Glycine; Insulin Receptor Substrate Proteins; Kinetics; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Precursors; Protein Serine-Threonine Kinases; Rats; Tumor Cells, Cultured; Wortmannin | 1997 |
Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes.
Topics: Adipocytes; Androstadienes; Animals; Biological Transport; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Wortmannin | 1997 |
Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Antibodies; Biological Transport; Cell Membrane; Deoxyglucose; Genistein; Glucose; Glucose Transporter Type 4; Insulin; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Nerve Tissue Proteins; Osmolar Concentration; Phosphotyrosine; Protein-Tyrosine Kinases; Qa-SNARE Proteins; Sorbitol; Wortmannin; Xylose | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway.
Topics: Androstadienes; Animals; Apoptosis; Cell Differentiation; Cell Division; Cell Line; Enzyme Inhibitors; Hematopoietic Stem Cells; Interleukin-4; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; ras Proteins; Receptors, Interleukin-4; Signal Transduction; Ubiquitin-Protein Ligases; Wortmannin | 1998 |
Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells.
Topics: Androstadienes; Animals; Antigens; Biological Transport; Cell Membrane; Dinitrophenols; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Inositol 1,4,5-Trisphosphate; Isoenzymes; Leukemia, Basophilic, Acute; Mast Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Receptors, IgE; Serum Albumin, Bovine; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin | 1998 |
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Receptors, Estrogen; Signal Transduction; Tumor Cells, Cultured; Wortmannin | 1998 |
Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase.
Topics: Androstadienes; Animals; Biological Transport; Cell Line; Chromones; Endocytosis; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Insulin; Isopropyl Thiogalactoside; Kidney Tubules; Kinetics; Morpholines; Opossums; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Receptors, Cell Surface; Serum Albumin; Transfection; Wortmannin | 1998 |
The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Mice; Molecular Sequence Data; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Phosphatase 1; Retroviridae Proteins, Oncogenic; Wortmannin | 1998 |
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cricetinae; Culture Media; Humans; Insulin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polyenes; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sequence Deletion; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 1998 |
Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I.
Topics: Androstadienes; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Glucose; Humans; Immunohistochemistry; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Wortmannin | 1998 |
Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension.
Topics: Androstadienes; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Hypertension; Insulin; Insulin Antagonists; Kinetics; Male; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thymidine; Tunica Media; Wortmannin | 1998 |
Hepatic stellate cells (vitamin A-storing cells) change their cytoskeleton structure by extracellular matrix components through a signal transduction system.
Topics: Androstadienes; Animals; Benzoquinones; Cell Size; Collagen; Cytoskeleton; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Humans; Lactams, Macrocyclic; Liver; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Staurosporine; Talin; Tumor Cells, Cultured; Vinculin; Vitamin A; Wortmannin | 1998 |
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
Topics: Androstadienes; Animals; Calcimycin; Calcium; Chromones; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Immunoglobulin E; Mast Cells; Mice; Mice, Knockout; Morpholines; Phosphatidylinositol Phosphates; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Receptors, IgE; src Homology Domains; Stem Cells; Wortmannin | 1998 |
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha.
Topics: Androstadienes; Cell Line; Chemokine CCL2; Chemotaxis; Enzyme Activation; Humans; Kinetics; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1998 |
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Cell Adhesion Molecules; Chromones; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cell Membrane; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Models, Biological; Morpholines; Neurites; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transfection; Tumor Cells, Cultured; Wortmannin | 1998 |
Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.
Topics: Androstadienes; DNA-Binding Proteins; Enzyme Inhibitors; Humans; I-kappa B Proteins; Jurkat Cells; NF-kappa B; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; src Homology Domains; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vanadates; Wortmannin | 1999 |
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
Topics: Androstadienes; Antibodies, Monoclonal; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Extracellular Matrix; Humans; Lymphokines; Membrane Proteins; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Receptors, Vitronectin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates.
Topics: 3T3 Cells; Androstadienes; Animals; Binding Sites; Inositol Phosphates; Ligands; Liposomes; Mice; Models, Molecular; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Signal Transduction; src Homology Domains; Wortmannin | 1999 |
Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK.
Topics: Androstadienes; Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; Connective Tissue Cells; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Histamine Release; In Vitro Techniques; Indole Alkaloids; Inositol Phosphates; Kinetics; Mast Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p-Methoxy-N-methylphenethylamine; Pertussis Toxin; Phosphotyrosine; Rats; Rats, Wistar; Signal Transduction; Tyrphostins; Vanadates; Virulence Factors, Bordetella; Wortmannin | 1999 |
Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate.
Topics: Androstadienes; Animals; Arsenicals; Cell Adhesion Molecules; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Myosin-Light-Chain Kinase; Neuroblastoma; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, Cholinergic; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
Topics: Androstadienes; Animals; Biological Transport; Cell Membrane; Cell Migration Inhibition; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Erythrocytes; Humans; Immunoglobulin G; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; Opsonin Proteins; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; Receptors, IgG; Sheep; Signal Transduction; Stilbenes; Syk Kinase; Wortmannin | 1999 |
Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes.
Topics: Androstadienes; Biological Transport; Carbazoles; Enzyme Activation; Erythrocytes; Humans; Indoles; Insulin; Isoenzymes; Maleimides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Sodium-Hydrogen Exchangers; Time Factors; Wortmannin | 2000 |
Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration.
Topics: Amidohydrolases; Androstadienes; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Chelating Agents; Cross-Linking Reagents; Cytochalasin B; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Indoles; Mice; Mice, Inbred BALB C; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Signal Transduction; Time Factors; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genistein; Imidazoles; Kinetics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Wortmannin | 2000 |
Activation of host cell phosphatidylinositol 3-kinases by Trypanosoma cruzi infection.
Topics: Androstadienes; Animals; Enzyme Activation; Isoenzymes; Macrophages, Peritoneal; Mice; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Subunits; Trypanosoma cruzi; Wortmannin | 2000 |
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate.
Topics: Amino Acid Sequence; Androstadienes; Animals; Cell Line; Cricetinae; Cytosol; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; Fluorescent Antibody Technique; HeLa Cells; Humans; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein Transport; Receptors, Cell Surface; Signal Transduction; Transfection; Wortmannin | 2000 |
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.
Topics: Amino Acid Substitution; Androstadienes; Animals; Arginine; Blood Proteins; Cysteine; Enzyme Inhibitors; Glutamic Acid; Humans; Interleukin-2; Jurkat Cells; Lysine; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Sequence Homology, Amino Acid; Signal Transduction; T-Lymphocytes; Transfection; Wortmannin | 2001 |
The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1.
Topics: Androstadienes; Animals; Cell Division; Cell Survival; Cells, Cultured; Chromatography, Thin Layer; Colony-Stimulating Factors; Enzyme Inhibitors; Fluorescent Antibody Technique; Osteoclasts; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Rats; Wortmannin | 2001 |
Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration.
Topics: Androstadienes; Antibodies, Monoclonal; Antigens, CD; Cell Line; Chemotaxis, Leukocyte; Cytoplasm; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Precursors; Epithelium; Extracellular Matrix; Humans; Integrin beta3; Intracellular Signaling Peptides and Proteins; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Syk Kinase; Wortmannin | 2001 |
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1.
Topics: Androstadienes; Animals; Binding Sites; Blood Proteins; COS Cells; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression; Humans; Insulin; Insulin Receptor Substrate Proteins; Mice; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Rabbits; Receptor, Insulin; Sequence Homology; Structure-Activity Relationship; Transfection; Wortmannin | 2001 |
Leptin stimulates rat aortic smooth muscle cell proliferation and migration.
Topics: Androstadienes; Animals; Aorta, Thoracic; Carrier Proteins; Cell Division; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; Leptin; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Rats; Receptors, Cell Surface; Receptors, Leptin; Wortmannin | 2001 |
Human VPS34 is required for internal vesicle formation within multivesicular endosomes.
Topics: Androstadienes; Antibodies, Monoclonal; Autocrine Communication; Carcinoma, Hepatocellular; Coated Vesicles; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Microinjections; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Transport; Tumor Cells, Cultured; Wortmannin | 2001 |
Regulation of phospholipase C-gamma 2 via phosphatidylinositol 3-kinase in macrophages.
Topics: Androstadienes; Animals; Cell Membrane; Cells, Cultured; Chromones; Cytoskeleton; Dose-Response Relationship, Drug; Female; Isoenzymes; Macrophages; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Prevotella intermedia; Protein Transport; Signal Transduction; Type C Phospholipases; Wortmannin; Zymosan | 2002 |
Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells.
Topics: Androstadienes; Animals; Bile Acids and Salts; Bile Canaliculi; Carbazoles; Cell Line; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; ras Proteins; Rats; Time Factors; Wortmannin | 2002 |
Local signaling by the EGF receptor.
Topics: Actin Depolymerizing Factors; Actins; Androstadienes; Animals; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Microfilament Proteins; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA, Small Interfering; Signal Transduction; Wortmannin | 2003 |
Signal transduction mechanisms of CD137 ligand in human monocytes.
Topics: 4-1BB Ligand; Alkaloids; Androstadienes; Benzophenanthridines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Pyrazoles; Pyrimidines; Signal Transduction; Thionucleotides; Wortmannin | 2007 |
Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells.
Topics: Actins; Analgesics, Opioid; Androstadienes; Breast Neoplasms; Caseins; Cell Line, Tumor; Cell Membrane; Cell Movement; Enzyme Activation; Female; Focal Adhesion Kinase 1; Humans; Melanoma; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; rac1 GTP-Binding Protein; Receptors, Androgen; Signal Transduction; Wortmannin | 2007 |
The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antigens, CD; Cell Line; Cytotoxicity, Immunologic; Extracellular Signal-Regulated MAP Kinases; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Models, Immunological; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C-delta; Proto-Oncogene Proteins c-vav; Receptors, Immunologic; Signal Transduction; Signaling Lymphocytic Activation Molecule Associated Protein; Signaling Lymphocytic Activation Molecule Family; Wortmannin | 2008 |
BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.
Topics: Actins; Amino Acid Sequence; Androstadienes; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Carrier Proteins; Cell Line; Chemotaxis; Class Ia Phosphatidylinositol 3-Kinase; HEK293 Cells; Humans; Inositol Phosphates; Membrane Proteins; Mesoderm; Mice; Microfilament Proteins; Models, Biological; Molecular Sequence Data; Myoblasts; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Pseudopodia; Signal Transduction; Wortmannin | 2014 |