phosphotyrosine has been researched along with tyrosine in 2366 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 413 (17.46) | 18.7374 |
| 1990's | 1705 (72.06) | 18.2507 |
| 2000's | 174 (7.35) | 29.6817 |
| 2010's | 56 (2.37) | 24.3611 |
| 2020's | 18 (0.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bixby, JL; Jhabvala, P | 2 |
| Chatila, T; Hanissian, SH; Sahyoun, NE | 1 |
| Amrein, KE; Hurley, TR; Sefton, BM | 1 |
| Bailey, TL; Burns, C; McVicar, DW; O'Shea, JJ; Smyth, MJ | 1 |
| Glenney, JR; Soppet, D | 1 |
| Campbell, MA; Fischer, WH; Schulte, RJ; Sefton, BM | 1 |
| Coghlan, MP; Field, CE; Ganderton, RH; Siddle, K; Soos, MA; Stanley, KK | 1 |
| Egerton, M; Quelle, FW; Samelson, LE; Wojchowski, DM | 1 |
| Goldstein, BJ; Hashimoto, N | 1 |
| Allee, G; Benarous, R; Bougeret, C; Brunati, AM; Cesaro, L; Donella-Deana, A; Fagard, R; Fischer, S; Marin, O; Pinna, LA | 1 |
| Perich, JW | 2 |
| Chou, MM; Fajardo, JE; Hanafusa, H | 1 |
| Andersson, LC; Auvinen, M; Hölttä, E; Paasinen, A | 1 |
| Babish, JG; Ma, X; Mufti, NA | 1 |
| Honda, Y; Iwaki, M; Kuriyama, S; Yoshimura, N | 1 |
| Desiderio, SV; Morrow, TA; Siliciano, JD | 1 |
| Freeman, RM; Neel, BG; Plutzky, J | 1 |
| Daly, C; Gutch, MJ; Reich, NC | 1 |
| Metzger, H; Pribluda, VS | 1 |
| Birchmeier, W; Comoglio, PM; Hartmann, G; Naldini, L; Sachs, M; Vigna, E; Weidner, KM | 1 |
| Bangalore, L; Laudano, AP; Stern, DF; Tanner, AJ | 1 |
| DeFranco, AL | 1 |
| Bliska, JB; Clemens, JC; Dixon, JE; Falkow, S | 1 |
| Azzoni, L; Kamoun, M; Kanakaraj, P; Perussia, B; Salcedo, TW | 1 |
| Abraham, RT; Karnitz, LM; Leibson, PJ; Schoon, RA; Ting, AT | 1 |
| Papkoff, J; Reynolds, AB; Wong, S | 1 |
| Maa, MC; Moyers, JS; Parsons, JT; Parsons, SJ; Vines, RR; Wilson, LK | 1 |
| Cooper, JA; Kussick, SJ | 1 |
| Courtneidge, SA; Dhand, R; Fry, MJ; Gout, I; Nguyen, O; Panayotou, G; Ruiz-Larrea, F; Waterfield, MD | 1 |
| Green, SP; Hamilton, JA; Phillips, WA | 1 |
| Heffetz, D; Rutter, WJ; Zick, Y | 1 |
| Barbacid, M; Jing, S; Tapley, P | 1 |
| Andersson, LC; Autero, M; Mustelin, T; Oetken, C; Ruutu, T; von Willebrand, M | 1 |
| Gelman, MS; Hadcock, JR; Malbon, CC; Port, JD | 1 |
| Baltimore, D; Cowburn, D; Mayer, B; Overduin, M; Rios, CB | 1 |
| Bunch, D; LeGuen, P; Leyton, L; Saling, PM | 1 |
| Chou, YH; Goldman, RD; Skalli, O | 1 |
| Aaronson, SA; Bottaro, DP; Chan, A; Ishibashi, T; Miki, T | 1 |
| Darnell, JE; Prezioso, VR; Schindler, C; Shuai, K | 1 |
| Borner, MM; McLellan, CA; Myers, CE; Sartor, O | 1 |
| Arteaga, CL; Awad, JA; Boland, CR; Coffey, RJ; Kraus, ER; Nanney, LB; Polk, WH; Romano, M; Wargovich, MJ | 1 |
| Goldfine, ID; Sung, CK | 1 |
| Arenas-Díaz, G; Marshall, SH; Muñoz, GE | 1 |
| Liu, J; Piotrowski, J; Slomiany, A; Slomiany, BL | 1 |
| Maassen, JA; Marani, E | 1 |
| Kikuchi, T; Krueger, J; Murphy, JS; Tamm, I | 1 |
| Ali, S; Chambon, P; Gaub, MP; Lutz, Y; Rochette-Egly, C; Scheuer, I | 1 |
| Knapp, AM; Knüchel, R; Mansbridge, JN; Sutherland, RM | 1 |
| Burridge, K; Romer, LH; Turner, CE | 2 |
| Bertuzzi, G; Chamak, B; Girault, JA; Greengard, P; Pang, DT; Tixier, H; Wang, JK | 1 |
| Puré, E; Tardelli, L | 1 |
| Bolen, JB; Grossmann, A; Hu, SL; Kanner, SB; Kavanagh, TJ; Ledbetter, JA; Rabinovitch, PS | 1 |
| Min, HK; Park, DJ; Rhee, SG | 1 |
| Bergeron, JJ; Lai, WH; Posner, BI; Wada, I | 1 |
| al-Ramadi, BK; Dianzani, U; Janeway, CA; Kubo, RT; Shaw, A | 1 |
| Ducker, TP; Goueli, SA; Skubitz, KM | 1 |
| Dasgupta, JD; Druker, B; Granja, C; Lin, LL; Relias, V; Yunis, EJ | 1 |
| Bolen, JB; Eiseman, E | 2 |
| Bannwarth, W; Burn, P; Cho, H; Itoh, M; Kitas, E; Ramer, SE; Saito, H; Walsh, CT | 1 |
| Baltimore, D; Jackson, PK; Mayer, BJ; Van Etten, RA | 1 |
| Chapdelaine, A; Chevalier, S; Durocher, Y; Nguyen, LT | 1 |
| Brugge, JS; Nelson, WJ; Schmidt, JW | 1 |
| Iwasaki, K; Kikuchi, H; Kondo, S; Matsumoto, M; Miyatake, S; Nakatsu, S; Namba, Y; Oda, Y | 1 |
| Alvarez, V; Mollinedo, F; Pulido, R; Sánchez-Madrid, F | 1 |
| Fukui, Y; Ichimori, Y; Kinoshita, Y; Toyoshima, K; Wongsasant, B; Yamamoto, T; Yamanashi, Y | 1 |
| Bonser, RW; Garland, LG; Hudson, AT; Randall, RW; Spacey, GD; Thompson, NT; Uings, IJ | 1 |
| Bordwell, KL; Mooney, RA | 1 |
| Leevers, SJ; Marshall, CJ | 1 |
| Kanner, SB; Ledbetter, JA; Schieven, GL; Thompson, CB; Turka, LA | 1 |
| Andersson, LC; Heiskala, M; Mustelin, T; Ståhls, A | 1 |
| Moolenaar, WH; Ploegh, HL; Verheijden, GF | 1 |
| Abraham, S; Dryden, P; Duronio, V; Schrader, JW; Welham, MJ | 1 |
| Afar, DE; Bell, JC; Stanners, CP | 1 |
| Harris, H; Winder, AJ | 1 |
| Benhamou, M; Gutkind, JS; Robbins, KC; Siraganian, RP; Stephan, V | 1 |
| Brass, LF; Brugge, JS; Hoxie, JA; Huang, MM; Indik, Z; Schreiber, AD | 1 |
| Ignelzi, MA; Maness, PF; Padilla, SS; Warder, DE | 1 |
| Chan, VW; DeFranco, AL; Gold, MR; Turck, CW | 1 |
| Hu, P; Lammers, R; Margolis, B; Schlessinger, J; Skolnik, EY; Ullrich, A | 1 |
| Pawson, T | 2 |
| Clark, SG; Horvitz, HR; Stern, MJ | 1 |
| Flynn, DC; Parsons, JT; Schaller, MD | 1 |
| Druker, BJ; Oda, A; Salzman, EW; Smith, M | 1 |
| Hata, D; Higashi, H; Hosoi, S; Kusunoki, T; Mayumi, M; Mikawa, H; Sugie, K | 1 |
| Morimoto, C; Nojima, Y; Rothstein, DM; Schlossman, SF; Sugita, K | 1 |
| Fletcher, MC; Freeman, GJ; June, CH; Kamoun, M; Ledbetter, JA; Nadler, LM; Thompson, CB; Turka, LA; Vandenberghe, P | 1 |
| Averill, BA; Crowder, MW; Vincent, JB | 1 |
| Banaszak, LJ; Bernlohr, DA; Buelt, MK; Xu, Z | 1 |
| Girault, JA; Hervé, D; Robel, L; Siciliano, JC | 1 |
| Elledge, SJ; Hall, FL; Harper, JW; Lodgson, N; Richman, R; Williams, RT | 1 |
| Atherton-Fessler, S; Parker, LL; Piwnica-Worms, H | 1 |
| Li, P; Roberts, TM; Williams, NG | 1 |
| Wang, JY; Welch, PJ | 1 |
| Dixon, JE; Rhodes, JD; Woodford-Thomas, TA | 1 |
| Boulet, I; Dunn, AR; Green, SP; Lock, P; Phillips, WA; Ralph, S; Stanley, E | 1 |
| Bolen, JB; Gutkind, JS; Ledbetter, JA; Robbins, KC; Thompson, PA | 1 |
| DeFranco, AL; Gold, MR; Grosschedl, R; Kelly, RB; Matsuuchi, L; Travis, A | 1 |
| Liao, F; Rhee, SG; Shin, HS | 2 |
| Aebersold, R; Pot, DA; Ramachandran, C; Tonks, NK | 1 |
| Bergeron, JJ; Burgess, JW; Khan, MN; Ling, N; Posner, BI; Wada, I | 1 |
| Ermel, B; Häring, HU; Kellerer, M; Lammers, R; Obermaier-Kusser, B; Tippmer, S; Ullrich, A; Vogt, B | 1 |
| del Rosario, M; Escobedo, JA; Fantl, WJ; Martin, GA; McCormick, F; Turck, CW; Williams, LT | 1 |
| Clark, R; Conroy, L; McCormick, F; Moran, MF; Müller, O; Polakis, P; Wong, G | 1 |
| Atashi, JR; Ingraham, CA; Klinz, SG; Maness, PF; Matten, WT; Schachner, M | 1 |
| Barbacid, M; Bryant, S; Klein, R; Lamballe, F | 1 |
| Druker, BJ; Griffin, JD; Hallek, M; Kanakura, Y; Okuda, K; Pelech, SL; Sanghera, JS | 1 |
| Bano, M; Dickson, RB; Kidwell, WR; Lippman, ME; Worland, P | 1 |
| Birge, RB; Fajardo, JE; Hanafusa, H; Mayer, BJ | 1 |
| Coggeshall, KM; Fukamachi, H; Inagaki, N; Ishizaka, K; Ishizaka, T; Kawakami, T; Takei, M | 1 |
| Cooper, JA; Kashishian, A; Kazlauskas, A; Valius, M | 1 |
| Afar, DE; Bell, JC; Ben-David, Y; Douville, EM; Howell, BW; Letwin, K; Pawson, T; Tannock, L | 1 |
| Abraham, N; Caron, L; Pawson, T; Veillette, A | 1 |
| Barbacid, M; Bustelo, XR | 1 |
| Anderson, SM; Erwin, JL | 1 |
| Brugge, JS; Foster, DA; Maroney, AC; Qureshi, SA | 1 |
| Baquiran, G; Bergeron, JJ; Faure, R; Posner, BI | 1 |
| Anderson, D; Garner, CW; Kuhné, MR; Lavan, BE; Lienhard, GE; Pawson, T; Reedijk, M | 1 |
| Biernat, J; Dorée, M; Döring, F; Drewes, G; Goris, J; Lichtenberg-Kraag, B; Mandelkow, E; Mandelkow, EM | 1 |
| Melamed, I; Roifman, CM; Wang, G | 1 |
| Chatila, T; Geha, RS; Spertini, F | 1 |
| Portnoy, DA; Smith, GA | 1 |
| Altman, A; Coggeshall, KM; McHugh, JC | 1 |
| Adamson, JW; Altschuler, D; Komatsu, N; Lapetina, EG; Marzocchini, R; Torti, M; Yamamoto, K | 1 |
| Kitamura, T; Miyajima, A | 1 |
| Barton, GJ; Breed, J; Russell, RB | 1 |
| Bulargina, TV; Kharitonenkov, AI; Muronetz, VV; Nagradova, NK; Sergienko, EA | 1 |
| Anderson, NG | 2 |
| Ballotti, R; Filloux, C; Scimeca, JC; Van Obberghen, E | 1 |
| Caron, MG; Hausdorff, WP; Kurose, H; Lefkowitz, RJ; Linder, ME; Luttrell, DK; Parsons, SJ; Pitcher, JA | 1 |
| Hunt, DF; Michel, H; Rossomando, AJ; Shabanowitz, J; Sturgill, TW; Weber, MJ; Wu, J | 1 |
| D'Andrea, A; Evans, GA; Farrar, WL; Linnekin, D | 1 |
| Biggs, WH; Zipursky, SL | 1 |
| Crumpton, MJ; Davies, AA; Ley, SC | 1 |
| Crouch, MF; Lapetina, EG; Torti, M | 1 |
| Donato, NJ; Rosenblum, MG; Steck, PA | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Davis, RJ; Latour, DA; Raden, DL; Stanley, K; Theroux, SJ | 1 |
| Christianson, TA; Clinton, GM; Lin, YJ | 1 |
| Bissoon, N; Gurd, JW; Woodrow, S | 1 |
| Petsko, GA | 1 |
| Baltimore, D; Birge, RB; Cowburn, D; Hanafusa, H; Kominos, D; Kuriyan, J; Mayer, BJ; Overduin, M; Pant, N; Resh, MD; Rios, CB; Robertson, SC; Silverman, L; Waksman, G | 1 |
| Del Rosario, M; Escobedo, J; Ives, HE; Marie, J; Mirda, D; Peters, KG; Williams, LT; Wilson, E | 1 |
| Dionne, CA; Honegger, AM; Jaye, M; Li, N; Li, W; Mohammadi, M; Schlessinger, J; Spivak, T | 1 |
| Guan, JL; Shalloway, D | 1 |
| Chen, YY; Rosenberg, N | 1 |
| Haystead, T; Hunt, DF; Michel, H; Rossomando, A; Shabanowitz, J; Sturgill, TW; Wu, J | 1 |
| Hirata, J; Nawata, H; Nishimura, J; Okamura, J; Sadamura, S; Shibata, K; Takahira, H; Umemura, T | 1 |
| Kadleck, T; Kohmetscher, MA; Koretzky, GA; Weiss, A | 1 |
| Roifman, CM; Wang, G | 1 |
| Carpenter, CL; Hou, W; Kapeller, R; Liu, Y; Schaffhausen, BS; Yoakim, M | 1 |
| Bierer, BE; Calvo, V; Crews, CM; Vik, TA | 1 |
| Lukas, TJ; Staros, JV; Woltjer, RL | 1 |
| Backer, JM; Chin, DJ; Hu, P; Margolis, B; Miralpeix, M; Myers, MG; Schlessinger, J; Shoelson, SE; Skolnik, EY; Sun, XJ | 1 |
| DaVolio, J; Garcia-Arenas, R; Lin, MF | 1 |
| Donato, NJ; Hittelman, WN; Newman, RA; Nishikawa, K; Pandita, TK; Rosenblum, MG | 1 |
| Aaronson, SA; Giese, N; LaRochelle, WJ; May-Siroff, M; Pierce, JH | 1 |
| Kume, T; Oishi, M; Watanabe, T | 1 |
| Billestrup, N; Carter-Su, C; Nielsen, JH; Norstedt, G; Talamantes, F; Uhler, MD; Wang, X | 1 |
| Cantley, LC; Kaplan, DR; Rabin, SL; Soltoff, SP | 1 |
| Miller, RA; Shi, J | 1 |
| Ashwell, JD; Burns, CM; Dumont, FJ; June, CH; Niklinska, BB; Volarević, S; Yamada, H | 1 |
| Hadari, YR; LeRoith, D; Nadiv, O; Roberts, CT; Rothenberg, P; Tzahar, E; Yarden, Y; Zick, Y | 1 |
| Alai, M; Barbacid, M; Bustelo, XR; Cutler, RL; Krystal, G; Mui, AL | 1 |
| Furuya, W; Grinstein, S | 2 |
| Bretscher, A; Burgess, WH; Chen, D; Druker, BJ; Egerton, M; Samelson, LE | 1 |
| Baltensperger, K; Czech, MP; Lewis, RE; Ross, AH; Vissavajjhala, P; Woon, CW | 1 |
| Crews, CM; Erikson, RL | 1 |
| Hanafusa, H; Krueger, J; Sudol, M; Zhao, Y | 1 |
| Anderson, SR; Fischer, EH; Malencik, DA; Zander, NF; Zhao, Z | 1 |
| Ståhls, A | 1 |
| Calas, B; Chavanieu, A; Grigorescu, F; Vaglio, P | 1 |
| Rozengurt, E; Sinnett-Smith, J; Zachary, I | 2 |
| Hunter, T; Krieg, J | 1 |
| Cohen, S; Donaldson, RW | 1 |
| Craighead, N; Fletcher, MC; June, CH; Thompson, CB; Turka, LA | 1 |
| Dy, RC; Earp, HS; Huckle, WR | 1 |
| Pelech, SL; Sanghera, JS | 1 |
| Dunn, WA; Fischer, JE; Humphreys-Beher, MG; Nakagawa, Y; Purushotham, KR; Schneyer, CA; Wang, PL | 1 |
| Baggio, B; Bordin, L; Clari, G; Moret, V | 1 |
| Bachelot, C; Eldor, A; Gazit, A; Gilon, C; Grelac, F; Levitzki, A; Levy-Toledano, S; Rendu, F | 1 |
| Green, SH; Qui, MS | 1 |
| Decker, SJ; Ohmichi, M; Saltiel, AR | 1 |
| Araki, E; Backer, JM; Miralpeix, M; Myers, MG; Sun, XJ; White, MF | 1 |
| Polya, GM; Wettenhall, RE | 1 |
| Farrar, WL; Linnekin, D; Park, LS | 1 |
| Damen, J; Hughes, P; Humphries, K; Krystal, G; Mui, AL | 1 |
| Adachi, T; Hirayama, E; Kim, J; Okada, Y; Yabubayashi, T | 1 |
| Ashe, OR; Burgess, WH; Chen, D; Druker, BJ; Egerton, M; Samelson, LE | 1 |
| Ficheux, D; Garbay-Jaureguiberry, C; Roques, BP | 1 |
| Havlik, MH; Muller, AJ; Pawson, T; Pendergast, AM; Puil, L; Witte, ON | 1 |
| Bradshaw, RA; Raffioni, S | 2 |
| Fukamachi, H; Ishizaka, K; Ishizaka, T; Kawakami, T; Kawakami, Y; Takei, M | 1 |
| Decker, SJ; Saltiel, AR; Zhu, G | 1 |
| Chang, E; Polverino, AJ; Ruderman, JV; Shibuya, EK; Wigler, M | 1 |
| Parker, LL; Piwnica-Worms, H | 1 |
| Chiang, TM | 1 |
| Ekholm, J; Hanahan, DJ; Javors, MA; Kimoto, M; Siafaka-Kapadai, A | 1 |
| Akimaru, K; Inoue, M; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Gold, MR; Pelech, SL; Sanghera, JS; Stewart, J | 1 |
| Adam, D; Blake, J; Bolen, JB; Fargnoli, J; Klages, S; Li, ZH; Mahajan, S; Prendergast, MM; Schieven, GL; Zhu, X | 1 |
| Bernhard, G; Brigitte, M; Christian, S; Patrizia, R | 1 |
| Berk, BC; Corson, MA; Duff, JL | 1 |
| Arima, N; Hattori, T; Imada, K; Itoh, K; Kodaka, T; Okuma, M; Tsudo, M; Uchiyama, T | 1 |
| Hempstead, BL; Kaplan, DR; Kaplan, L; Parada, LF; Rabin, SJ; Reid, S | 1 |
| Beeler, JF; Heidaran, MA; Jensen, RA; LaRochelle, WJ | 1 |
| Lamphere, L; Lienhard, GE | 1 |
| Bockholt, SM; Burridge, K; Glenney, JR; Otey, CA | 1 |
| Argetsinger, LS; Shafer, JA | 1 |
| Backer, JM; Folli, F; Kahn, CR; Saad, MJ | 2 |
| Ebina, Y; Fukui, Y; Hayashi, H; Kamohara, S; Kanai, F; Miyake, N; Nishioka, Y; Shibasaki, F; Takenawa, T | 1 |
| Backer, JM; Glasheen, EM; Kahn, CR; Miralpeix, M; Myers, MG; Sun, XJ; White, MF | 1 |
| Marengere, LE; Pawson, T | 1 |
| Enberg, B; Hansson, A; Lobie, PE; Möller, C; Norstedt, G | 1 |
| Angeletti, RH; Berg, KL; Pixley, FJ; Stanley, ER; Yeung, YG | 1 |
| Cantrell, DA; Fry, MJ; Ley, S; Reif, K; Ward, SG; Waterfield, MD | 1 |
| Evans, G; Farrar, WL; Linnekin, D; Michiel, D | 1 |
| Colamonici, OR; Platanias, LC | 1 |
| Djeu, JY; Evans, GA; Farrar, WL; Kelly, PA; Rui, H | 1 |
| Brugge, JS; Cobb, BS; Haimovich, B; Lipfert, L; Parsons, JT; Schaller, MD | 1 |
| Grosmaire, L; Kanner, SB; Ledbetter, JA; Masewicz, S; Odum, N; Svejgaard, A | 1 |
| Caon, AC; Gaudry, M; Gilbert, C; Lille, S; Naccache, PH | 1 |
| Abraham, RT; Dick, CJ; Einspahr, KJ; Leibson, PJ | 2 |
| Bird, TA; Saklatvala, J | 1 |
| Furuya, W; Grinstein, S; Lu, DJ; Mills, GB | 1 |
| Endemann, G; Roth, RA; Yonezawa, K | 1 |
| Chen, WS; Gill, GN; Rosenfeld, MG; Walton, GM | 1 |
| Jin, YJ; Kaplan, DR; Reinherz, EL; Roberts, TM; Spagnoli, GC; White, M | 1 |
| Brown, MH; Cantrell, DA; Crumpton, MJ; Desai, D; Monostori, E | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Howard, BD; Zhong, XH | 1 |
| Kozma, LM; Reynolds, AB; Weber, MJ | 1 |
| Ellis, C; McCormick, F; Moran, M; Pawson, T | 1 |
| Dutta, A; Hamaguchi, M; Hanafusa, H | 1 |
| Carpenter, G; Kim, JW; Kim, UH; Nishibe, S; Rhee, SG; Sim, SS; Wahl, MI | 1 |
| Carpenter, G; Kim, H; Kim, JW; Nishibe, S; Rhee, SG; Wahl, MI | 1 |
| Brock, T; Kahn, CR; Karasik, A; Pepinsky, RB; Reddy, SS | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Jarjour, WN; Mimura, T; Minota, S; Roubey, RA; Winfield, JB | 1 |
| Dotto, GP; Filvaroff, E; Stern, DF | 1 |
| Ely, CM; Kanner, SB; Litz, JS; Oddie, KM; Parsons, SJ; Rossomando, AJ; Sturgill, TW | 1 |
| Fletcher, MC; June, CH; Ledbetter, JA; Samelson, LE | 1 |
| King, MJ; Sale, GJ | 1 |
| Argetsinger, LS; Shafer, JA; Whitehouse-Hills, S | 1 |
| Casnellie, JE; Thom, RE | 3 |
| Gelfand, EW; Hill, M; May, C; McGill, M; Mellors, A; Mills, GB; Stanley, J; Stewart, DJ | 1 |
| Huganir, RL; Moritz, E; Qu, ZC | 1 |
| Donella-Deana, A; Hofsteenge, J; Pinna, LA; Stone, SR | 1 |
| Andersen, AC; Kinsey, WH; Peaucellier, G | 1 |
| Gaulton, GN; Merida, I | 1 |
| Hanafusa, H; Mayer, BJ | 2 |
| Dhar, A; Paul, AK; Shukla, SD | 1 |
| Kaplan, DR; Morrison, DK; Rhee, SG; Williams, LT | 1 |
| Kato, JY; Reinherz, EL; Roussel, MF; Sherr, CJ; Transy, C | 1 |
| Asai, J; Hamaguchi, M; Isobe, K; Ito, M; Iwamoto, T; Misawa, N; Nakashima, I; Takahashi, M; Yoshida, T | 1 |
| Grunberger, G; Levy, J; Nagy, K | 1 |
| Anderson, SR; Malencik, DA; Zhao, ZZ | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Dalrymple, BL; Etheredge, JL; Niedbalski, JS; Ringer, DP | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Demos, M; Duronio, V; Howard, SL; Hudson, AT; Jones, K; Pelech, SL; Reany, A; Salari, H | 1 |
| Akanuma, Y; Kasuga, M; Koshio, O; Takaku, F; Tashiro-Hashimoto, Y; Tobe, K | 1 |
| Clark, EA; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| Smolen, JE; Stoehr, SJ; Suchard, SJ | 1 |
| Granot, Y; Schrier, RW; Van Putten, V | 1 |
| Blode, H; Diringer, H; Heinrich, T | 1 |
| Chung, A; Hill, M; May, C; Mills, GB; Zhang, N | 1 |
| Ferrell, JE; Martin, GS | 2 |
| Ermel, B; Häring, HU; Kellerer, M; Obermaier-Kusser, B; Petrides, PE; Wallner, U | 1 |
| Roth, RA; Steele-Perkins, G | 1 |
| Cozzone, AJ; Dadssi, M | 1 |
| Berkow, RL; Dodson, RW | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Livingston, JN; Moss, AM; Moxley, RT; Unger, JW | 1 |
| Cohen, B; Piwnica-Worms, H; Roberts, TM; Schaffhausen, BS; Yoakim, M | 1 |
| DeFranco, AL; Gold, MR; Law, DA | 1 |
| Andrulis, IL; Blackstein, ME; Pawson, T; Wildenhain, Y | 1 |
| Fukui, Y; Hanafusa, H; Matsuda, M; Mayer, BJ | 1 |
| Brindle, NP; Dickens, M; Siddle, K; Tavare, JM; Whittaker, J | 1 |
| Downey, GP; Grinstein, S; Pâquet, MR; Trudel, S | 1 |
| Johns, RB; Kitas, EA; Meggio, F; Perich, JW; Pinna, LA; Valerio, RM | 1 |
| Kudryavtseva, NV; Nikolsky, NN; Reshetnikova, GF; Sorokin, AB | 1 |
| Iwashita, S; Mitsui, K | 2 |
| Alemany, S; Strålfors, P | 1 |
| Adrian, I; Mihalache, O; Muhr, A; Schweiger, A | 1 |
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| Béchet, E; Fleurie, A; Grangeasse, C; Gruszczyk, J; Kahn, R; Meyer, P; Moréra, S; Nessler, S; Olivares-Illana, V; Pompidor, G; Zanella-Cleon, I | 1 |
| Bonet, S; Casas, I; Fàbrega, A; Pinart, E; Puigmulé, M; Yeste, M | 1 |
| DiGiovanni, J; Fässler, R; Geiger, T; Mann, M; Meves, A; Zanivan, S | 1 |
| Heck, AJ; Muñoz, J; Zoumaro-Djayoon, AD | 1 |
| Kim, HJ; Kim, JS; Song, SU | 1 |
| Edelson-Averbukh, M; Lehmann, WD; Pipkorn, R; Shevchenko, A | 1 |
| Alder, N; Byzova, T; Deshmukh, L; Meller, N; Vinogradova, O | 1 |
| Artemenko, KA; Lind, SB; Pettersson, U | 1 |
| Gelkop, S; Isakov, N; Pulak, RN; Weisman, B; Zharhary, D | 1 |
| Duysen, EG; Jiang, W; Lockridge, O | 1 |
| Huang, SY; Liang, RP; Qiu, JD; Shi, SP; Sun, XY; Suo, SB | 1 |
| Hatano, N; Kameshita, I; Katayama, S; Sueyoshi, N; Sugiyama, Y; Terachi, T | 1 |
| Liu, BA; Nash, PD | 1 |
| Buntru, A; Frank, R; Hauck, CR; Kopp, K; Pils, S; Zimmermann, T; Zumbusch, A | 1 |
| Anderson, KI; Bleijerveld, OB; Corradini, E; Heck, AJ; Kolch, W; Müller, PJ; Preisinger, C; Scholten, A; Schwarz, JP | 1 |
| Bomke, J; Dresing, V; Frech, M; Grädler, U; Greiner, H; Jäkel, S; Müller-Pompalla, D; Musil, D; Rysiok, T; Schwarz, D; Wegener, A | 1 |
| Klerman, H; Levine, E; McClendon, CL; Rapp, C | 1 |
| Cramer, R; Gout, I; Gout, R; Kovaleva, V; Krynytskyy, H | 1 |
| Bollman, J; Cerny, R; Guo, J; Ju, T; Niu, W; Roy, A | 1 |
| Deuel, TF | 1 |
| Di Palma, S; Heck, AJ; Munoz, J; Peng, M; Post, H; Preisinger, C; Zoumaro-Djayoon, A | 1 |
| Arntzen, MØ; Kalland, ME; Koehler, CJ; Landskron, J; Strozynski, M; Størvold, GL; Taskén, K; Thiede, B | 1 |
| Devaraju, KS; Gopi, A; Harish, BM; Kumar, BS; Saraswathi, R; Sureshbabu, SV | 1 |
| Barkinge, JL; Chuu, CP; Ciaccio, MF; Hause, RJ; Jones, RB; Leung, KK | 1 |
| Afonso, A; Pereira, P; Queiroz, JA; Sousa, Â; Sousa, F | 1 |
| Bai, Y; Chen, YA; Dhillon, J; Fang, B; Fishman, M; Haake, SM; Haura, EB; Kinose, F; Koomen, JM; Li, J; Pow-Sang, JM; Rathmell, WK; Welsh, EA; Zent, R | 1 |
| Cheng, L; Chiang, HC; Curiel, TJ; Elledge, R; Gupta, HB; Gupta, K; Hu, Y; Lathrop, K; Li, R; McHardy, S; Sareddy, GR; Vadlamudi, R; Wang, D; Wang, P; Ye, Q; Yuan, B | 1 |
| Dong, X; He, L; Hung, W; Lee, AR; Liu, L; Xie, N | 1 |
| Besson, A; Burlet-Schiltz, O; Callot, C; Davy, A; Fawal, M; Froment, C; Jungas, T; Perchey, RT | 1 |
| Alvarez, LA; Bourke, B; Cean, A; Daff, S; Friedmacher, F; Ghişe, A; Gosemann, JH; Knaus, UG; Kovačič, L; Kubica, M; Pircalabioru, GG; Plettner, E; Puri, P; Rodríguez, J; Sărăndan, MB; von Kriegsheim, A | 1 |
| Beausoleil, SA; Erickson, AR; Everley, RA; Gygi, SP; Huttlin, EL | 1 |
| Buhs, S; Nollau, P | 1 |
| Abe, Y; Adachi, J; Nagano, M; Tada, A; Tomonaga, T | 1 |
| Dong, M; Li, Y; Wang, Y; Ye, M; Zou, H | 1 |
| Awasthi, S; Bansal, M; Belkina, N; Biswas, R; Califano, A; Chaerkady, R; Charles Jacob, HK; Cultraro, CM; Gao, S; Guha, U; Kashyap, MK; Kirkali, G; Maity, T; Marimuthu, A; Pandey, A; Pitts, S; Singh, S; Venugopalan, A; Zhang, X | 1 |
| Hoppmann, C; Hunter, T; Li, S; Shokat, KM; Wang, L; Wong, A; Yang, B | 1 |
| Dwinell, MB; Getschman, AE; Koplinski, CA; Moussouras, NA; Payne, RJ; Peterson, FC; Phillips, AJ; Richard, AM; Taleski, D; Veldkamp, CT; Volkman, BF | 1 |
| Bian, Y; Chen, L; Dong, J; Dong, M; Lv, J; Mao, J; Wang, H; Wang, Y; Yao, Y; Ye, M | 1 |
| Chen, G; Dann, C; Trinidad, JC; Zhang, Y | 1 |
| Freyzon, Y; Kritzer, JA; Lindquist, S | 1 |
| Colville, K; Labandera, AM; Moorhead, GB; Ng, KKS; Uhrig, RG | 1 |
| Graham, B; Hübner, R; Joshi, T; Kubeil, M; Nsubuga, A; Sgarzi, M; Stephan, H; Steudtner, R; Zarschler, K | 1 |
| Banerjee, SL; Bernard, DN; Bisson, N; Bourassa, S; Chartier, FJM; Dionne, U; Doucet, N; Gagné, JP; Gish, GD; Jacquet, K; Jain, M; Landry, CR; Laprise, P; Lavoie, N; López de Los Santos, Y; Otis, F; Poirier, GG; Tremblay, MG; Voyer, N | 1 |
| Queiroz, JA; Sousa, A; Sousa, F; Valente, JFA | 1 |
| Borne, AL; Brulet, JW; Ciancone, AM; Hahm, HS; Hsu, KL; Libby, AH; McCloud, RL; Toroitich, EK; Ware, TB; Yuan, K | 1 |
| Ahsan, N; Miernyk, JA; Rao, RSP; Sabila, M; Salvato, F; Ullah, H; Wilson, RS | 1 |
| Hu, L; Hu, X; Huang, T; Liao, H; Wang, M | 1 |
| de Pereda, JM; Heemskerk, N; Kreft, M; Schuring, J; Sonnenberg, A; Te Molder, L; Wilhelmsen, K | 1 |
| Ishihama, Y; Niinae, T; Otaka, A; Tsumagari, K | 1 |
| Li, M; Liu, Y; Lu, W; Na, B; Qin, H; Qing, G; Tang, M; Wang, D; Xiong, Y | 1 |
| Dong, M; Hu, L; Liu, X; Mao, J; Wang, Y; Yao, L; Yao, Y; Ye, M | 1 |
| Testini, C | 1 |
| Chen, Y; Guo, J; He, X; Ma, B; Niu, W | 1 |
| Jin, L; Lei, Q; Murshed, A; Ogbuehi, AC; Peng, Q; Sun, F; Wang, H; Zhang, Y; Zhong, Q | 1 |
| Feng, Y; Jin, X; Liu, J; Peng, P; Qu, Y; Shu, H; Wang, L; Wang, Y; Wei, M; Xia, M | 1 |
| Cai, Z; Chen, W; Kong, Q; Li, P; Tian, R; Weng, Y; Zheng, Z | 1 |
| Dembélé, P; Garnier, O; Martin, DK; Vilgrain, I | 1 |
| Cai, Z; He, A; Ke, M; Kong, Q; Li, P; Qin, Y; Tian, R; Weng, Y | 1 |
| Boggon, TJ; Stiegler, AL; Vish, KJ | 1 |
| Diop, A; Gianni, S; Malagrinò, F; Marcocci, L; Nardella, C; Pagano, L; Pennacchietti, V; Pietrangeli, P; Santorelli, D; Toto, A | 1 |
| Gagoski, D; Lee, M; Li, A; Shah, NH; Voleti, R | 1 |
| Brownridge, PJ; Byrne, DP; Daly, LA; Eyers, CE; Eyers, PA; Jones, AR; McDonnell, E; Perkins, S | 1 |
57 review(s) available for phosphotyrosine and tyrosine
| Article | Year |
|---|---|
Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor.
Topics: Animals; Cell Membrane; Humans; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Receptors, Antigen, B-Cell; Signal Transduction; Tyrosine | 1992 |
Protein tyrosine phosphatases: a novel family of enzymes involved in transmembrane signalling.
Topics: Amino Acid Sequence; Antigens, CD; Antigens, Differentiation; CD4 Antigens; Female; Histocompatibility Antigens; Humans; Leukocyte Common Antigens; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphotyrosine; Placenta; Pregnancy; Protein Tyrosine Phosphatases; Receptors, Leukocyte-Adhesion; Sequence Homology, Nucleic Acid; Signal Transduction; T-Lymphocytes; Tyrosine | 1990 |
The world according to GAP.
Topics: Enzyme Activation; Gene Expression Regulation, Enzymologic; Genes, Fungal; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Oncogene Protein p21(ras); Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Saccharomyces cerevisiae; Tyrosine | 1990 |
Tyrosine kinase and control of cell proliferation.
Topics: Carcinoma; Cell Division; Enzyme Activation; ErbB Receptors; Humans; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Stomach Neoplasms; Tumor Cells, Cultured; Tyrosine | 1990 |
Protein phosphorylation and cell transformation.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, src; Humans; Neoplasm Proteins; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1991 |
Phosphotyrosine antibodies as probes for activated oncogene products endowed with tyrosine kinase activity.
Topics: Animals; Antibodies; Biomarkers, Tumor; Carcinoma; Cell Division; Cricetinae; Enzyme Activation; Fibroblasts; Growth Substances; Membrane Proteins; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cell Surface; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Tyrosine | 1991 |
Microbial pathogenesis and tyrosine dephosphorylation: surprising 'bedfellows'.
Topics: Amino Acid Sequence; Bacterial Proteins; Humans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Homology, Nucleic Acid; Tyrosine; Vaccinia virus; Viral Proteins; Yersinia | 1991 |
Structure/function analysis of the invariant subunits of the T cell antigen receptor.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation, B-Lymphocyte; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cytoplasm; Macromolecular Substances; Membrane Glycoproteins; Membrane Proteins; Mice; Molecular Sequence Data; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Fc; Receptors, IgE; Structure-Activity Relationship; Tyrosine | 1991 |
Multiple signal transduction pathways activated through the T cell receptor for antigen.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Histocompatibility Antigens; Interleukin-2; Leukocyte Common Antigens; Lymphocyte Activation; Mice; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1991 |
After insulin binds.
Topics: DNA; Drosophila; ErbB Receptors; Humans; Insulin; Molecular Weight; Oncogenes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Substrate Specificity; Tyrosine | 1987 |
Antibodies to the insulin receptor as tools in the study of receptor structure and function.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Humans; Insulin; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Receptor, Insulin; Tyrosine | 1987 |
Protein tyrosine kinases associated with human malignancies.
Topics: Antibodies, Neoplasm; Carcinoma, Small Cell; Cell Division; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Neoplasm Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Cell Surface; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Tyrosine | 1987 |
Phosphorylation of estradiol receptor on tyrosine and interaction of estradiol and glucocorticoid receptors with antiphosphotyrosine antibodies.
Topics: Antibodies; Antigen-Antibody Complex; Calcium-Calmodulin-Dependent Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Estradiol; Receptors, Estrogen; Receptors, Glucocorticoid; Tyrosine | 1988 |
Antibodies for phosphotyrosine: analytical and preparative tool for tyrosyl-phosphorylated proteins.
Topics: Antibodies; Antibody Formation; Antibody Specificity; Immunochemistry; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine | 1988 |
Phosphoprotein phosphatases.
Topics: Alkaline Phosphatase; Allosteric Regulation; Animals; Cations; Glutathione; Glutathione Disulfide; Glycogen-Synthase-D Phosphatase; Immunoglobulin G; Isoenzymes; Liver; Membrane Proteins; Molecular Weight; Muscles; Phosphoprotein Phosphatases; Phosphotyrosine; Pyruvate Dehydrogenase Complex; Rabbits; Rats; Substrate Specificity; Tyrosine | 1982 |
Phosphotyrosyl-protein phosphatases.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Cell Transformation, Viral; Oncogenes; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Retroviridae; Tyrosine | 1983 |
Tyrosine protein kinases and their substrates: an overview.
Topics: ErbB Receptors; L-Lactate Dehydrogenase; Muscle Proteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphoglycerate Mutase; Phosphopyruvate Hydratase; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae; Tyrosine; Vinculin; Viral Proteins | 1984 |
The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation.
Topics: Animals; CD4 Antigens; Cells, Cultured; Humans; Kinetics; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; src-Family Kinases; Substrate Specificity; T-Lymphocytes; Transfection; Tyrosine | 1995 |
A positive addition to a negative tail's tale.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Repetitive Sequences, Nucleic Acid; RNA Polymerase II; RNA, Messenger; Tyrosine | 1993 |
Closing in on SH2 specificity.
Topics: Amino Acid Sequence; Binding Sites; Molecular Sequence Data; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptor Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1993 |
Molecular determinants of insulin action.
Topics: Animals; Humans; Insulin; Insulin Receptor Substrate Proteins; Phosphoproteins; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway.
Topics: Animals; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Structural; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; T-Lymphocytes; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1994 |
The interleukin-4 receptor: signal transduction by a hematopoietin receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cytokines; Hematopoietic Cell Growth Factors; Humans; Insulin Receptor Substrate Proteins; Interleukin-4; Models, Structural; Molecular Sequence Data; Multigene Family; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Interleukin-4; Receptors, Mitogen; Signal Transduction; Tyrosine | 1994 |
Paxillin: a cytoskeletal target for tyrosine kinases.
Topics: Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Embryonic and Fetal Development; Extracellular Matrix; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinculin | 1994 |
Rap1b and platelet function.
Topics: Amino Acid Sequence; Blood Platelets; Erythropoietin; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Iloprost; Isoenzymes; Molecular Sequence Data; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Platelet Activation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); rap GTP-Binding Proteins; ras GTPase-Activating Proteins; Sequence Homology, Amino Acid; Signal Transduction; Thrombin; Type C Phospholipases; Tyrosine | 1993 |
The identification of JAK2 tyrosine kinase as a signaling molecule for growth hormone.
Topics: Animals; Growth Hormone; Humans; Janus Kinase 2; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Signal Transduction; Tyrosine | 1994 |
Receptor domains involved in signal transduction of prolactin and growth hormone.
Topics: Animals; Humans; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Receptors, Prolactin; Receptors, Somatotropin; Signal Transduction; Tyrosine | 1994 |
Cytokine receptors and signal transduction.
Topics: Amino Acid Sequence; Animals; Base Sequence; Humans; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Receptors, Cytokine; Signal Transduction; Tyrosine | 1994 |
Transmembrane signaling by IFN-alpha.
Topics: Animals; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon-alpha; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Receptors, Interferon; Signal Transduction; Transcription, Genetic; Tyrosine | 1994 |
Crystal structure of the phosphotyrosine recognition domain SH2 of the Src oncogene product complexed with tyrosine-phosphorylated peptides.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallization; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oncogene Proteins; Peptides; Phosphotyrosine; Protein Binding; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1994 |
Adhesive signaling in platelets.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Fibrinogen; Humans; Integrin beta1; Integrins; Ligands; Models, Biological; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Receptors, Cytoadhesin; Signal Transduction; Tyrosine | 1994 |
Neurotrophin signalling.
Topics: Animals; Cell Survival; Cells, Cultured; Humans; Intracellular Membranes; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 1994 |
SH2 and SH3 domains in signal transduction.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Gene Expression Regulation; Genes, ras; GRB2 Adaptor Protein; Humans; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Signal Transduction; Tyrosine | 1994 |
Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5.
Topics: Animals; DNA-Binding Proteins; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Interleukin-5; Mice; Milk Proteins; Phosphorylation; Phosphotyrosine; Sheep; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Binding Sites; Consensus Sequence; Homeostasis; Humans; Mice; Mice, Mutant Strains; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; Tyrosine | 1995 |
Phosphorylation of the nicotinic acetylcholine receptor by protein tyrosine kinases.
Topics: Agrin; Amino Acid Sequence; Animals; Chickens; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Nicotinic; Sequence Alignment; Sequence Homology, Amino Acid; Synapses; Torpedo; Tyrosine | 1995 |
A new flavor in phosphotyrosine recognition.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Humans; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1995 |
The PTB domain: a new protein module implicated in signal transduction.
Topics: Amino Acid Sequence; Antigens, Polyomavirus Transforming; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; ras Proteins; Receptor, Insulin; Receptors, Growth Factor; Signal Transduction; Tyrosine | 1995 |
Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; Consensus Sequence; Cytokine Receptor gp130; DNA-Binding Proteins; Endocytosis; Gene Expression Regulation; Haptoglobins; Humans; Interleukin-6; Membrane Glycoproteins; Molecular Sequence Data; Peptides; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Interleukin; Receptors, Interleukin-6; RNA, Messenger; Signal Transduction; Solubility; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Topics: Amino Acid Sequence; Animals; Humans; Insulin; Molecular Sequence Data; Molecular Structure; Mutagenesis; Phosphotyrosine; Receptor, Insulin; Tyrosine | 1993 |
Strategies for nonradioactive methods in the localization of phosphorylated amino acids in proteins.
Topics: Amino Acid Sequence; Amino Acids; Mass Spectrometry; Molecular Sequence Data; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1993 |
Signalling by receptor tyrosine kinases.
Topics: Animals; Growth Substances; Mutagenesis; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Tyrosine | 1993 |
Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells.
Topics: Animals; Brain; Cell Line; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Insulin; Insulin-Like Growth Factor I; Mice; Molecular Weight; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
Modulation of biological tyrosine reactions by tyrosine phosphorylation.
Topics: Animals; Cell Differentiation; Cell Division; Dihydroxyphenylalanine; Diiodotyrosine; Free Radicals; Humans; Monoiodotyrosine; Phosphorylation; Phosphotyrosine; Tyrosine | 1995 |
Structure and function of the protein tyrosine phosphatases.
Topics: Amino Acid Sequence; Animals; Binding Sites; cdc25 Phosphatases; Cell Cycle Proteins; Conserved Sequence; Cyanobacteria; Cyclin-Dependent Kinase Inhibitor Proteins; Dual-Specificity Phosphatases; Humans; Hydrolysis; Models, Molecular; Molecular Sequence Data; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rhodobacter; Saccharomyces cerevisiae Proteins; Salmonella; Substrate Specificity; Tyrosine | 1996 |
Tyrosine phosphorylation and cadherin/catenin function.
Topics: Animals; beta Catenin; Binding Sites; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Desmoplakins; gamma Catenin; Humans; Models, Biological; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Trans-Activators; Tyrosine | 1997 |
Integrin signaling: tyrosine phosphorylation events in focal adhesions.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Membrane; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Models, Biological; Models, Structural; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1998 |
[The role of tyrosine phosphorylation in the regulation of cell proliferation and differentiation in lower eukaryotes].
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Division; Conserved Sequence; Dictyostelium; Eukaryotic Cells; Gene Expression Regulation, Enzymologic; MAP Kinase Signaling System; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Saccharomyces cerevisiae; Signal Transduction; Tetrahymena; Tyrosine | 2003 |
Tensin.
Topics: Actins; Animals; Binding Sites; Focal Adhesions; Gene Expression; Humans; Microfilament Proteins; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; src Homology Domains; Substrate Specificity; Tensins; Tissue Distribution; Tyrosine | 2004 |
Electrochemistry/mass spectrometry (EC/MS)--a new tool to study drug metabolism and reaction mechanisms.
Topics: Chemistry Techniques, Analytical; Chromatography, Liquid; Electrochemistry; Ferrous Compounds; Mass Spectrometry; Metallocenes; Metalloproteins; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Peptides; Phosphotyrosine; Tyrosine | 2004 |
Peptidomics, current status.
Topics: Arginine; Chromatography, Affinity; Combinatorial Chemistry Techniques; Cysteine; Histidine; Humans; Lysine; Methionine; Peptides; Phosphotyrosine; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2005 |
Src kinase regulation by phosphorylation and dephosphorylation.
Topics: Animals; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; src-Family Kinases; Tyrosine | 2005 |
The role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes.
Topics: Animals; Eukaryotic Cells; Growth Substances; Models, Biological; Phosphorylation; Phosphotyrosine; Protein Kinases; ras Proteins; Signal Transduction; STAT Transcription Factors; Tyrosine | 2006 |
Evolution of SH2 domains and phosphotyrosine signalling networks.
Topics: Amino Acid Sequence; Animals; Binding Sites; Eukaryota; Evolution, Molecular; Humans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Interaction Mapping; Protein-Tyrosine Kinases; Signal Transduction; src Homology Domains; Tyrosine | 2012 |
Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway.
Topics: Anaplastic Lymphoma Kinase; Carrier Proteins; Cytokines; Enzyme Activation; Gene Expression Regulation; Humans; Ligands; Neurons; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Signal Transduction; Tyrosine | 2013 |
Mass Spectrometry-Based Identification of Phospho-Tyr in Plant Proteomics.
Topics: Amino Acid Motifs; Chromatography, Affinity; Gene Ontology; Mass Spectrometry; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plants; Protein Processing, Post-Translational; Proteome; Proteomics; Signal Transduction; src Homology Domains; Tyrosine | 2020 |
SH2 Domains: Folding, Binding and Therapeutical Approaches.
Topics: Binding Sites; Phosphotyrosine; Protein Binding; Signal Transduction; src Homology Domains; Tyrosine | 2022 |
2309 other study(ies) available for phosphotyrosine and tyrosine
| Article | Year |
|---|---|
Inhibition of tyrosine phosphorylation potentiates substrate-induced neurite growth.
Topics: Animals; Brain; Catechols; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Chick Embryo; Culture Media; Extracellular Matrix Proteins; Genistein; Isoflavones; Nerve Tissue Proteins; Neurites; Neurons; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; Tyrosine; Tyrphostins; Vanadates | 1992 |
Association of neuronal pp60c-src with growth cone glycoproteins of rat brain.
Topics: Animals; Animals, Newborn; Axons; Brain; Brain Chemistry; Cell Membrane; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Membrane Glycoproteins; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1992 |
Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Transformation, Viral; Cells, Cultured; Enzyme Stability; Escherichia coli; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oncogene Proteins, Viral; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Sequence Homology, Amino Acid; Temperature; Thermodynamics; Tyrosine | 1992 |
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Cytosol; Flow Cytometry; Gene Expression Regulation; Humans; Hydrogen Peroxide; Immunoblotting; Kinetics; Lymphocyte Activation; Mice; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Interleukin-2; RNA; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1992 |
Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Caveolin 1; Caveolins; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Fibroblasts; Fluorescent Antibody Technique; Gene Expression; Gizzard, Avian; Membrane Proteins; Mice; Molecular Sequence Data; Muscle, Smooth; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Transfection; Tyrosine | 1992 |
Tyrosine phosphorylation of CD22 during B cell activation.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Burkitt Lymphoma; Cell Adhesion Molecules; Chymotrypsin; Humans; Immunoblotting; Immunosorbent Techniques; Lectins; Lymphocyte Activation; Peptide Mapping; Phosphorylation; Phosphotyrosine; Sialic Acid Binding Ig-like Lectin 2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Cell Membrane; Epitopes; Humans; Immunosorbent Techniques; Liver; Mice; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Placenta; Rats; Receptor, Insulin; Tyrosine | 1992 |
Cytokine-induced phosphorylation of pp100 in FDC-ER cells is at tyrosine residues.
Topics: Animals; Cells, Cultured; Cytokines; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Erythropoietin; Tyrosine | 1992 |
Differential regulation of mRNAs encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase C.
Topics: Animals; Culture Media, Serum-Free; Enzyme Activation; Half-Life; Insulin; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1992 |
Spleen protein tyrosine kinases TPK-IIB and CSK display different immunoreactivity and opposite specificities toward c-src-derived peptides.
Topics: Amino Acid Sequence; Calmodulin; CSK Tyrosine-Protein Kinase; ErbB Receptors; Humans; Molecular Sequence Data; Peptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins pp60(c-src); Spleen; src-Family Kinases; Substrate Specificity; Tyrosine | 1992 |
Efficient solid phase synthesis of mixed Thr(P)-, Ser(P)- and Tyr(P)-containing phosphopeptides by "global" "phosphite-triester" phosphorylation.
Topics: Amino Acid Sequence; Esters; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Tyrosine | 1992 |
The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Humans; Immunoblotting; Ligands; Mice; Mice, Inbred BALB C; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Oncogene Proteins; Phosphotyrosine; Rats; Retroviridae Proteins, Oncogenic; Sulfhydryl Compounds; Tyrosine; Vanadates | 1992 |
Ornithine decarboxylase activity is critical for cell transformation.
Topics: 3T3 Cells; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Transformation, Neoplastic; DNA; Eflornithine; Gene Expression; Genes, src; Humans; Mice; Molecular Sequence Data; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphotyrosine; Proto-Oncogene Mas; Rats; RNA, Antisense; Transfection; Tyrosine | 1992 |
Protein tyrosine phosphorylation as an indicator of 2,3,7,8-tetrachloro-p-dioxin exposure in vivo and in vitro.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Humans; Liver; Mice; Mice, Inbred C57BL; Molecular Weight; Oxidoreductases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polychlorinated Dibenzodioxins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tyrosine | 1992 |
Growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial cells.
Topics: Adenosine Triphosphate; Autoradiography; Cells, Cultured; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Eye Proteins; Fetus; Fibroblast Growth Factor 2; Humans; Membrane Proteins; Phosphorylation; Phosphotyrosine; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Signal Transduction; Tyrosine | 1992 |
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.
Topics: Base Sequence; Cloning, Molecular; DNA; Enzyme Induction; Interleukin-2; Lymphocyte Activation; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Consensus Sequence; DNA; Gene Expression; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine | 1992 |
Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor.
Topics: Base Sequence; DNA-Binding Proteins; HeLa Cells; Humans; In Vitro Techniques; Interferon-alpha; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interferon; Regulatory Sequences, Nucleic Acid; Signal Transduction; Transcription Factors; Transcription, Genetic; Tyrosine | 1992 |
Transmembrane signaling by the high-affinity IgE receptor on membrane preparations.
Topics: Animals; Cell Membrane; In Vitro Techniques; Macromolecular Substances; Mast Cells; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptors, IgE; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Movement; Cells, Cultured; DNA; DNA Mutational Analysis; Dogs; Hepatocyte Growth Factor; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptors, Cell Surface; Recombinant Proteins; Structure-Activity Relationship; Tyrosine | 1992 |
Antiserum raised against a synthetic phosphotyrosine-containing peptide selectively recognizes p185neu/erbB-2 and the epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Blotting, Western; Epitopes; ErbB Receptors; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Mice; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1992 |
The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophage.
Topics: Animals; Antibodies, Monoclonal; Bacterial Outer Membrane Proteins; Cell Line; Macrophages; Mice; Phosphoproteins; Phosphotyrosine; Plasmids; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Restriction Mapping; Substrate Specificity; Tyrosine; Virulence; Yersinia pseudotuberculosis | 1992 |
Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.
Topics: Antibodies, Monoclonal; Cell Membrane; Humans; Isoenzymes; Killer Cells, Natural; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1992 |
Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells.
Topics: Antibody-Dependent Cell Cytotoxicity; Benzoquinones; Cell Line; Enzyme Activation; Humans; Immunoblotting; Isoenzymes; Killer Cells, Natural; Kinetics; Lactams, Macrocyclic; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, IgG; Rifabutin; Type C Phospholipases; Tyrosine | 1992 |
Platelet activation leads to increased c-src kinase activity and association of c-src with an 85-kDa tyrosine phosphoprotein.
Topics: Amino Acid Sequence; Antibodies; Blood Platelets; Electrophoresis, Polyacrylamide Gel; Genes, src; Humans; Molecular Sequence Data; Molecular Weight; Oligopeptides; Phosphoproteins; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tyrosine | 1992 |
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.
Topics: Animals; Cell Line; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Fluorescent Antibody Technique; Genes, src; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Transfection; Tyrosine | 1992 |
Overexpressed Drosophila src 64B is phosphorylated at its carboxy-terminal tyrosine, but is not catalytically repressed, in cultured Drosophila cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Drosophila; Drosophila Proteins; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Genes, src; Hot Temperature; Immunoblotting; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Transfection; Tyrosine; Vertebrates | 1992 |
Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Chromatography, Affinity; Consensus Sequence; Molecular Sequence Data; Molecular Weight; Peptides; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1992 |
Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents.
Topics: Animals; Benzoquinones; Bone Marrow Cells; Cells, Cultured; Cinnamates; Enzyme Activation; In Vitro Techniques; Interferon-gamma; Lactams, Macrocyclic; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred CBA; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Respiratory Burst; Rifabutin; Sulfides; Tumor Necrosis Factor-alpha; Tyrosine; Vanadates; Zymosan | 1992 |
The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells.
Topics: Animals; CHO Cells; Cricetinae; Hydrogen Peroxide; In Vitro Techniques; Insulin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine; Vanadates | 1992 |
Nerve growth factor mediates signal transduction through trk homodimer receptors.
Topics: 3T3 Cells; Animals; Cell Line; Cysteine; Humans; Kinetics; Macromolecular Substances; Methionine; Mice; Nerve Growth Factors; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine; Vanadates | 1992 |
Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells.
Topics: Aged; Animals; Arsenicals; Blood Platelets; Busulfan; Cell Line; Dithiothreitol; Gene Rearrangement; Granulocytes; Humans; Hydroxyurea; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1992 |
Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.
Topics: Animals; Cell Line; Cricetinae; GTP-Binding Proteins; Insulin; Iodine Radioisotopes; Isoproterenol; Kinetics; Male; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Adrenergic, beta; Tyrosine; Vas Deferens | 1992 |
Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.
Topics: Amino Acid Sequence; Animals; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphotyrosine; Protein Structure, Secondary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Recombinant Proteins; Sequence Alignment; Tyrosine | 1992 |
Regulation of mouse gamete interaction by a sperm tyrosine kinase.
Topics: Acrosome; Animals; Catechols; Cell Membrane; Egg Proteins; Female; Ligands; Male; Membrane Glycoproteins; Mice; Nitriles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Sperm-Ovum Interactions; Tyrosine; Tyrphostins; Zona Pellucida Glycoproteins | 1992 |
Cell cycle-dependent changes in the organization of an intermediate filament-associated protein: correlation with phosphorylation by p34cdc2.
Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cells, Cultured; Cricetinae; Fluorescent Antibody Technique; In Vitro Techniques; Intermediate Filament Proteins; Intermediate Filaments; Mitosis; Peptide Mapping; Phosphorylation; Phosphotyrosine; Tyrosine; Vimentin | 1992 |
Expression cloning of a human dual-specificity phosphatase.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Gene Expression; Humans; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphoserine; Phosphotyrosine; Restriction Mapping; RNA, Messenger; Sequence Alignment; Substrate Specificity; Tyrosine | 1992 |
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
Topics: Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; GTP-Binding Proteins; Interferon-alpha; Interferon-gamma; Models, Biological; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine | 1992 |
Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines.
Topics: 3T3 Cells; Animals; Dose-Response Relationship, Drug; Humans; Male; Mice; Molecular Weight; Neoplasm Proteins; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prostatic Neoplasms; Suramin; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.
Topics: Animals; Aspirin; Dinoprostone; Ethanol; Ethylmaleimide; Gastric Mucins; Gastric Mucosa; Image Processing, Computer-Assisted; Indomethacin; Microscopy, Electron, Scanning; Necrosis; Ornithine Decarboxylase; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Time Factors; Transforming Growth Factor alpha; Type C Phospholipases; Tyrosine | 1992 |
Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex.
Topics: Animals; Antibodies; Humans; Insulin; Kinetics; Liver Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Rats; Receptor, Insulin; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Exogenously added free phosphotyrosine induces aggregation of circulating platelets in rabbits.
Topics: Animals; Cells, Cultured; Electrocardiography; Heart Diseases; In Vitro Techniques; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Rabbits; Tyrosine | 1992 |
Inhibition of EGF-induced gastric mucosal calcium channel phosphorylation by ebrotidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Ulcer Agents; Benzenesulfonates; Calcium Channels; Calcium Radioisotopes; Epidermal Growth Factor; Gastric Mucosa; Isradipine; Phosphorylation; Phosphotyrosine; Rats; Thiazoles; Tyrosine | 1992 |
Phosphotyrosine localization in the mature rat brain.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antibody Specificity; Brain Chemistry; Female; Male; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rabbits; Rats; Receptors, Cell Surface; Spinal Cord; Tyrosine | 1992 |
Dissociation between early loss of actin fibres and subsequent cell death in serum-deprived quiescent Balb/c-3T3 cells.
Topics: 3T3 Cells; Actins; Animals; Cell Adhesion; Cell Death; Cell Survival; Culture Media; Growth Substances; GTP-Binding Proteins; Interphase; Mice; Phosphotyrosine; Signal Transduction; Tyrosine | 1992 |
Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Blotting, Western; Carrier Proteins; Cell Line; Chlorocebus aethiops; Humans; Immunoelectrophoresis; Kidney; Mice; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Rabbits; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Transfection; Tyrosine | 1992 |
Importance of tyrosine phosphatases in the effects of cell-cell contact and microenvironments on EGF-stimulated tyrosine phosphorylation.
Topics: Blotting, Western; Cell Communication; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1992 |
Signaling between the extracellular matrix and the cytoskeleton: tyrosine phosphorylation and focal adhesion assembly.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Line; Cytoskeleton; Extracellular Matrix; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tyrosine | 1992 |
Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin.
Topics: Animals; Astrocytes; Brain; Cell Aggregation; Cerebral Cortex; Embryo, Mammalian; Epidermal Growth Factor; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred Strains; Neurons; Phosphorylation; Phosphotyrosine; Tyrosine | 1992 |
Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Down-Regulation; Endocytosis; Female; Immunoglobulin D; Immunoglobulin M; Ligands; Lymphocyte Activation; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Tyrosine | 1992 |
Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Cells, Cultured; Ethylmaleimide; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Sulfhydryl Compounds; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1992 |
Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Kinetics; Muromonab-CD3; Peptide Mapping; Phosphates; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases; Tyrosine | 1992 |
Association of the tyrosine phosphorylated epidermal growth factor receptor with a 55-kD tyrosine phosphorylated protein at the cell surface and in endosomes.
Topics: Amino Acid Sequence; Cell Compartmentation; Cell Membrane; Down-Regulation; Endocytosis; Endosomes; ErbB Receptors; Intracellular Membranes; Macromolecular Substances; Membrane Proteins; Molecular Sequence Data; Molecular Weight; Peptide Mapping; Peptides; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine | 1992 |
Physical association of CD4 with the T cell receptor.
Topics: Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; CD4 Antigens; CD4-Positive T-Lymphocytes; Clone Cells; Cross-Linking Reagents; Cytochalasin D; Epitopes; H-2 Antigens; Histocompatibility Antigens Class II; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Mice; Nocodazole; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, T-Cell; Tyrosine | 1992 |
CD66 monoclonal antibodies recognize a phosphotyrosine-containing protein bearing a carcinoembryonic antigen cross-reacting antigen on the surface of human neutrophils.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Antigens, Neoplasm; Bile; Carcinoembryonic Antigen; Cell Adhesion Molecules; Cross Reactions; Humans; Lewis X Antigen; Membrane Glycoproteins; Molecular Weight; Neutrophils; Phosphoproteins; Phosphotyrosine; Tyrosine | 1992 |
Phospholipase C-gamma 1 association with CD3 structure in T cells.
Topics: Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Line; Humans; Immunoblotting; Kinetics; Macromolecular Substances; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1992 |
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases.
Topics: 2,4-Dinitrophenol; Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Dinitrophenols; Enzyme Activation; Immunoglobulin E; Kinetics; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; src-Family Kinases; Tyrosine | 1992 |
Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism.
Topics: Amino Acid Sequence; Antigens, CD; Catalysis; Cytoplasm; Escherichia coli; Genetic Vectors; Histocompatibility Antigens; HLA Antigens; Humans; Leukocyte Common Antigens; Membrane Glycoproteins; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Tyrosine | 1992 |
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cloning, Molecular; DNA Mutational Analysis; Humans; Immunoblotting; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oncogene Proteins v-abl; Phosphotyrosine; Retroviridae; Tyrosine | 1992 |
The major form of protein tyrosine kinase in the dog prostate is expressed by a 50 kDa polypeptide.
Topics: Animals; Cytosol; Dogs; Electrophoresis, Gel, Two-Dimensional; Isoelectric Point; Male; Molecular Weight; Phosphorylation; Phosphotyrosine; Prostate; Protein Denaturation; Protein-Tyrosine Kinases; Tyrosine | 1992 |
pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation.
Topics: Animals; Cadherins; Cell Adhesion; Cell Aggregation; Cell Communication; Cell Differentiation; Embryonal Carcinoma Stem Cells; Epithelial Cells; Epithelium; Keratins; Neoplastic Stem Cells; Neurofilament Proteins; Neurons; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Tretinoin; Tumor Cells, Cultured; Tyrosine | 1992 |
Analysis of the close relationship between human astrocytoma-specific antigens detected by murine monoclonal antibodies and c-kit proto-oncogene product.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Astrocytoma; Cell Line; Glioma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Molecular Weight; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Tyrosine | 1992 |
Biochemical and functional characterization of the leucocyte tyrosine phosphatase CD45 (CD45RO, 180 kD) from human neutrophils. In vivo upregulation of CD45RO plasma membrane expression on patients undergoing haemodialysis.
Topics: Antigens, CD; Cell Membrane; Histocompatibility Antigens; Humans; Leukocyte Common Antigens; Leukocyte Count; Molecular Weight; Neutrophils; Phosphotyrosine; Renal Dialysis; Tyrosine; Up-Regulation | 1992 |
Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.
Topics: B-Lymphocytes; Enzyme Activation; Humans; Immunoglobulin M; In Vitro Techniques; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1992 |
Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil.
Topics: Enzyme Activation; Humans; Indoles; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Type C Phospholipases; Tyrosine | 1992 |
Insulin stimulates the tyrosine phosphorylation of a 61-kilodalton protein in rat adipocytes.
Topics: Adipose Tissue; Animals; Cell Fractionation; Immunoblotting; Insulin; Male; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1992 |
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Enzyme Activation; Flow Cytometry; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Phosphates; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Signal Transduction; Tyrosine | 1992 |
CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; CD28 Antigens; CD3 Complex; CD4 Antigens; Cells, Cultured; Histocompatibility Antigens; In Vitro Techniques; Leukocyte Common Antigens; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Receptor Aggregation; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Thymus Gland; Type C Phospholipases; Tyrosine | 1992 |
Activation of natural killer cells via the Fc gamma RIII (CD16) requires initial tyrosine phosphorylation.
Topics: Antibody-Dependent Cell Cytotoxicity; Antigens, Differentiation; Cytotoxicity, Immunologic; Genistein; Inositol Phosphates; Isoflavones; Killer Cells, Natural; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgG; Signal Transduction; Tyrosine | 1992 |
Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.
Topics: Adenoviruses, Human; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Membrane; Down-Regulation; Endoplasmic Reticulum; ErbB Receptors; Histocompatibility Antigens Class I; Humans; KB Cells; Kinetics; Oligosaccharides; Phosphotyrosine; Receptors, Transferrin; Time Factors; Tyrosine | 1992 |
p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.
Topics: Animals; Cells, Cultured; Cytokines; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; In Vitro Techniques; Interleukin-3; Mast Cells; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Receptors, Cell Surface; Signal Transduction; Tyrosine | 1992 |
Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoembryonic Antigen; Cell Adhesion Molecules; Glycoproteins; Humans; In Vitro Techniques; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Sequence Alignment; Tumor Cells, Cultured; Tyrosine | 1992 |
Induction of tyrosinase in human melanoma cells by L-tyrosine phosphate and cytochalasin D.
Topics: Blotting, Northern; Cytochalasin D; DNA; Enzyme Induction; Humans; Melanoma; Monophenol Monooxygenase; Phosphotyrosine; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase | 1992 |
Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.
Topics: 3T3 Cells; Animals; Antigens, Differentiation, B-Lymphocyte; Carbachol; Cell Line; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoglobulin E; Inositol Phosphates; Isoflavones; Kinetics; Leukemia, Basophilic, Acute; Mice; Models, Biological; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fc; Receptors, IgE; Receptors, Muscarinic; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1992 |
Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Blood Platelets; Cell Line; Enzyme Activation; Humans; Immunoglobulin E; Leukemia, Erythroblastic, Acute; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgE; Tyrosine | 1992 |
Altered expression of pp60c-src induced by peripheral nerve injury.
Topics: Animals; Axons; Biomarkers; Chickens; Enzyme Induction; Female; Motor Neurons; Nerve Crush; Nerve Regeneration; Neurons, Afferent; Peripheral Nerve Injuries; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); S100 Proteins; Schwann Cells; Sciatic Nerve; Tyrosine | 1992 |
Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.
Topics: Animals; B-Lymphocytes; Cell Line; Immunoglobulin M; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Receptors, Antigen, B-Cell; Tyrosine | 1992 |
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
Topics: 3T3 Cells; Animals; Cell Line; ErbB Receptors; Gene Expression; Humans; Immunoblotting; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sulfhydryl Compounds; Tyrosine | 1992 |
Cell signalling. Conviction by genetics.
Topics: Amino Acid Sequence; Animals; Caenorhabditis; Genes; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1992 |
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Topics: Alleles; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis; Chromosome Mapping; DNA; DNA Mutational Analysis; Genes; Genes, Suppressor; Molecular Sequence Data; Phenotype; Phosphoproteins; Phosphotyrosine; Signal Transduction; Tyrosine | 1992 |
Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.
Topics: Animals; Cells, Cultured; Chick Embryo; Cloning, Molecular; In Vitro Techniques; Membrane Proteins; Molecular Weight; Neurons; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1992 |
Inhibition by sodium nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Blotting, Western; Cyclic GMP; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Kinetics; Nitroprusside; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Thrombin; Tyrosine | 1992 |
Tyrosine phosphorylation and its possible role in superoxide production by human neutrophils stimulated with FMLP and IgG.
Topics: Humans; Immunoglobulin G; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotyrosine; Protein-Tyrosine Kinases; Superoxides; Tyrosine | 1992 |
Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Enzyme Activation; Fibronectins; Humans; In Vitro Techniques; Integrin beta1; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, T-Cell; Receptors, Very Late Antigen; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD28 Antigens; Histocompatibility Antigens; Humans; In Vitro Techniques; Interleukin-2; Lactams, Macrocyclic; Leukocyte Common Antigens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Quinones; Receptor Aggregation; Receptors, Cell Surface; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Multiple binding sites for tetrahedral oxyanion inhibitors of bovine spleen purple acid phosphatase.
Topics: Acid Phosphatase; Adenosine Monophosphate; Animals; Arsenates; Binding, Competitive; Cattle; Kinetics; Oxidation-Reduction; Phosphates; Phosphotyrosine; Spleen; Substrate Specificity; Tyrosine | 1992 |
Structural and functional characterization of the phosphorylated adipocyte lipid-binding protein (pp15).
Topics: Animals; Binding Sites; Carrier Proteins; Cell Line; Chromatography; Circular Dichroism; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Mice; Molecular Structure; Neoplasm Proteins; Nerve Tissue Proteins; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics; Tyrosine | 1992 |
Stimulation of protein-tyrosine phosphorylation in rat striatum after lesion of dopamine neurons or chronic neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Basal Ganglia; Corpus Striatum; Dopamine; Male; Molecular Weight; Motor Activity; Nerve Tissue Proteins; Oxidopamine; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine | 1992 |
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; Gene Expression; HeLa Cells; Humans; Lymphocytes; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Substrate Specificity; Tyrosine | 1992 |
p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.
Topics: CDC2 Protein Kinase; Cell Cycle Proteins; In Vitro Techniques; Nuclear Proteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Substrate Specificity; Tyrosine | 1992 |
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.
Topics: Animals; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Moths; Oncogene Protein pp60(v-src); Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Tyrosine | 1992 |
Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.
Topics: 3T3 Cells; Animals; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cells, Cultured; Cyclins; Fibroblasts; Gene Expression; HeLa Cells; Humans; In Vitro Techniques; Macromolecular Substances; Mesothelin; Mice; Phosphotyrosine; RNA, Messenger; Transcription, Genetic; Tyrosine | 1992 |
Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Endoplasmic Reticulum; Gene Expression; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Tyrosine Phosphatases; Transfection; Tyrosine | 1992 |
Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.
Topics: Animals; Bone Marrow Cells; Gene Expression; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Respiratory Burst; RNA, Messenger; src-Family Kinases; Tyrosine; Vanadates | 1992 |
Identification of distinct populations of PI-3 kinase activity following T-cell activation.
Topics: Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4-Positive T-Lymphocytes; Humans; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Receptor Aggregation; Receptors, Antigen, T-Cell; Second Messenger Systems; Signal Transduction; src-Family Kinases; Tyrosine | 1992 |
The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.
Topics: Animals; Antigens, CD; CD79 Antigens; Cell Line; Cell Membrane; Immunoglobulin mu-Chains; Inositol Phosphates; Membrane Glycoproteins; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Restriction Mapping; Signal Transduction; Transfection; Tyrosine | 1992 |
Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.
Topics: Antigens, Differentiation; Arsenicals; Calcium; Cell Line; Cross-Linking Reagents; Humans; Immunoglobulin G; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Receptors, Fc; Receptors, IgG; Type C Phospholipases; Tyrosine | 1992 |
Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Substrate Specificity; Time Factors; Tyrosine | 1992 |
Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Endocytosis; Female; Insulin; Kinetics; Liver; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1992 |
Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Activation; Fibroblasts; Genetic Variation; Humans; Insulin; Kinetics; Peptide Fragments; Peptide Mapping; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Trypsin; Tyrosine | 1992 |
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cell Division; Cells, Cultured; CHO Cells; Cricetinae; DNA Mutational Analysis; GTP Phosphohydrolases; GTPase-Activating Proteins; In Vitro Techniques; Mice; Molecular Sequence Data; Peptide Mapping; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1992 |
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; DNA-Binding Proteins; GTPase-Activating Proteins; Heterogeneous-Nuclear Ribonucleoproteins; Insect Hormones; Insect Proteins; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Proteins; Recombinant Proteins; Ribonucleoproteins; RNA-Binding Proteins; Sequence Alignment; Tyrosine | 1992 |
Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes.
Topics: Animals; Antibodies, Monoclonal; Brain; Cadherins; Cell Adhesion Molecules, Neuronal; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Fibronectins; Immunoglobulin Fab Fragments; Laminin; Neurons; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Inbred Strains; Signal Transduction; Tubulin; Tyrosine | 1992 |
The trkB tyrosine protein kinase is a receptor for neurotrophin-4.
Topics: Adrenal Gland Neoplasms; Animals; Base Sequence; Binding Sites; Binding, Competitive; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line; Cell Line, Transformed; Mice; Molecular Sequence Data; Mutagenesis; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Pheochromocytoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured; Tyrosine; Xenopus | 1992 |
Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase.
Topics: Amino Acid Sequence; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Immunoblotting; Interleukin-3; Molecular Sequence Data; Neutrophils; Phosphotyrosine; Protein Kinases; Recombinant Proteins; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1992 |
Receptor-induced phosphorylation by mammary-derived growth factor 1 in mammary epithelial cell lines.
Topics: Blotting, Western; Breast; Breast Neoplasms; Cell Line; Cross-Linking Reagents; Epithelial Cells; Epithelium; ErbB Receptors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Receptors, Growth Factor; Tumor Cells, Cultured; Tyrosine | 1992 |
Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.
Topics: Animals; Binding, Competitive; Cell Line, Transformed; Chick Embryo; Cloning, Molecular; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Glutathione Transferase; GTPase-Activating Proteins; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphorylation; Phosphotyrosine; Plasmids; Polymerase Chain Reaction; Proteins; Proto-Oncogene Proteins c-abl; Radioimmunoprecipitation Assay; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Type C Phospholipases; Tyrosine | 1992 |
Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cross-Linking Reagents; Genistein; Histamine Release; Immunoglobulin E; Inositol 1,4,5-Trisphosphate; Isoflavones; Mast Cells; Mice; Mice, Inbred CBA; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgE; Signal Transduction; Type C Phospholipases; Tyrosine | 1992 |
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.
Topics: Animals; Binding Sites; Cells, Cultured; Dogs; GTPase-Activating Proteins; In Vitro Techniques; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein Binding; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1992 |
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Compartmentation; Cell Membrane; Cloning, Molecular; Cytoplasm; DNA; Gene Expression; In Vitro Techniques; Mice; Molecular Sequence Data; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; RNA, Messenger; Sequence Alignment; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Topics: Animals; Cells, Cultured; DNA Mutational Analysis; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mutagenesis, Site-Directed; Myristates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1992 |
Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells.
Topics: Amino Acids; Animals; B-Lymphocytes; Cell Cycle Proteins; Cell Line; Kinetics; Lymphocyte Activation; Mice; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Tyrosine | 1992 |
Analysis of phosphotyrosine-containing proteins present in v-src-infected myeloid progenitor cells.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Cell Line, Transformed; Chick Embryo; Genes, src; Hematopoietic Stem Cells; Interleukin-3; Kinetics; Mice; Molecular Weight; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1992 |
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Chick Embryo; Cloning, Molecular; DNA-Binding Proteins; Early Growth Response Protein 1; Fibroblasts; Gene Expression Regulation, Viral; Genes, src; Immediate-Early Proteins; Mice; Molecular Sequence Data; Muscles; Oligodeoxyribonucleotides; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Temperature; Transcription Factors; Transcription, Genetic; Tyrosine; Viral Proteins; Zinc Fingers | 1992 |
The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s).
Topics: Adenosine Triphosphate; Animals; Autoradiography; Blotting, Western; Cell Nucleolus; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Female; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Inbred Strains; Receptor, Insulin; Temperature; Tyrosine | 1992 |
The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; GTPase-Activating Proteins; Insulin; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Proteins; ras GTPase-Activating Proteins; Receptor, Insulin; Sequence Homology, Nucleic Acid; Substrate Specificity; Type C Phospholipases; Tyrosine | 1992 |
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
Topics: Alzheimer Disease; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chromatography, Ion Exchange; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinases; Recombinant Proteins; Reference Values; Substrate Specificity; Swine; tau Proteins; Tyrosine | 1992 |
Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein.
Topics: B-Lymphocytes; Gene Expression; Genes, fos; GTP-Binding Proteins; Inositol Phosphates; Lymphocyte Activation; Pertussis Toxin; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; RNA, Messenger; Second Messenger Systems; Signal Transduction; Type C Phospholipases; Tyrosine; Virulence Factors, Bordetella | 1992 |
Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; Calcium; CD3 Complex; Cytokines; Gene Expression; Histocompatibility Antigens; HLA-D Antigens; Humans; In Vitro Techniques; Inositol Phosphates; Lactams, Macrocyclic; Leukocyte Common Antigens; Lymphocyte Activation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor Aggregation; Receptors, Antigen, T-Cell; Rifabutin; RNA, Messenger; Second Messenger Systems; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Cell biology. Devious devices of Salmonella.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; Microscopy, Electron; Microvilli; Phosphotyrosine; Salmonella typhimurium; Signal Transduction; Tyrosine | 1992 |
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Humans; Immune Sera; Immunoblotting; Isoenzymes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Signal Transduction; Spleen; T-Lymphocytes; Tyrosine | 1992 |
Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7.
Topics: Erythropoietin; Guanosine Triphosphate; Hematopoiesis; Humans; In Vitro Techniques; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
Functional reconstitution of the human interleukin-3 receptor.
Topics: Animals; Cell Division; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Interleukin-2; Interleukin-3; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Signal Transduction; Species Specificity; Structure-Activity Relationship; Transfection; Tyrosine | 1992 |
Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains.
Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogene Protein v-akt; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins, Oncogenic; Sequence Homology, Nucleic Acid; Tyrosine | 1992 |
D-glyceraldehyde-3-phosphate dehydrogenase purified from rabbit muscle contains phosphotyrosine.
Topics: Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Immunoblotting; Muscles; Phosphorylation; Phosphotyrosine; Rabbits; Tyrosine | 1992 |
Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Growth Hormone; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tyrosine | 1992 |
Insulin and orthovanadate stimulate multiple phosphotyrosine-containing serine kinases.
Topics: Amino Acid Sequence; Animals; Cytosol; DNA; Enzyme Activation; Fibroblasts; Humans; Insulin; Isoenzymes; Mice; Molecular Sequence Data; Molecular Weight; Oligopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Insulin; Recombinant Proteins; Stimulation, Chemical; Tyrosine; Vanadates | 1992 |
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
Topics: Animals; Fluorides; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Structure-Activity Relationship; Tyrosine | 1992 |
Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Mass Spectrometry; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Recombinant Proteins; Tyrosine | 1992 |
Association of the erythropoietin receptor with protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Animals; Electrophoresis, Gel, Two-Dimensional; Erythropoietin; Friend murine leukemia virus; Gene Products, env; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Erythropoietin; Signal Transduction; Tyrosine | 1992 |
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Drosophila melanogaster; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein Kinases; Sequence Alignment; Signal Transduction; Tyrosine | 1992 |
CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD5 Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Epinephrine induces association of pp60src with Gi alpha in human platelets.
Topics: Blood Platelets; Blotting, Western; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Epinephrine; GTP-Binding Proteins; Molecular Weight; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Thrombin; Tyrosine | 1992 |
Tumor necrosis factor regulates tyrosine phosphorylation on epidermal growth factor receptors in A431 carcinoma cells: evidence for a distinct mechanism.
Topics: ErbB Receptors; Humans; Kinetics; Phosphopeptides; Phosphorylation; Phosphotyrosine; Radioligand Assay; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; Substrate Specificity; Thymidine; Transfection; Tyrosine | 1992 |
Disulfide-linked and noncovalent dimers of p185HER-2 in human breast carcinoma cells.
Topics: Alkylating Agents; Antibodies; Breast Neoplasms; Disulfides; Humans; Iodoacetates; Iodoacetic Acid; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1992 |
Depolarization-dependent tyrosine phosphorylation in rat brain synaptosomes.
Topics: Animals; Animals, Newborn; Brain; Calcium; Electrophysiology; Phosphorylation; Phosphotyrosine; Potassium; Rats; Synaptosomes; Tyrosine; Veratridine | 1992 |
Signal transduction. Fishing in Src-infested waters.
Topics: Crystallography; Magnetic Resonance Spectroscopy; Oncogene Protein pp60(v-src); Peptides; Phosphotyrosine; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1992 |
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides.
Topics: Amino Acid Sequence; Binding Sites; Crystallography; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptides; Phosphotyrosine; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Sequence Alignment; Signal Transduction; Solvents; Tyrosine; X-Ray Diffraction | 1992 |
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium; Fibroblast Growth Factors; In Vitro Techniques; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligodeoxyribonucleotides; Peptides; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Signal Transduction; Structure-Activity Relationship; Transfection; Type C Phospholipases; Tyrosine | 1992 |
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.
Topics: Animals; Base Sequence; Fibroblast Growth Factors; In Vitro Techniques; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Mapping; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Signal Transduction; Structure-Activity Relationship; Type C Phospholipases; Tyrosine | 1992 |
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Line; Cell Transformation, Viral; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunologic Techniques; In Vitro Techniques; Integrins; Membrane Glycoproteins; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1992 |
Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.
Topics: Abelson murine leukemia virus; Animals; B-Lymphocytes; Cell Death; Cell Line, Transformed; Clone Cells; G1 Phase; Genes, abl; Molecular Weight; Oncogene Proteins v-abl; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1992 |
Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, Gel; Female; Mass Spectrometry; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Molecular Weight; Muscles; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Denaturation; Protein Kinases; Rabbits; Sequence Homology, Nucleic Acid; Tyrosine | 1992 |
Differences in tyrosine phosphorylated proteins between cells expressing P210bcr/abl and P190bcr/abl.
Topics: Fusion Proteins, bcr-abl; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line.
Topics: Antigens, CD; Blotting, Western; Calcium; Cloning, Molecular; Histocompatibility Antigens; Humans; In Vitro Techniques; Leukocyte Common Antigens; Phosphatidylinositols; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Second Messenger Systems; Signal Transduction; T-Lymphocytes; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner.
Topics: Adenosine Triphosphate; B-Lymphocytes; Benzylidene Compounds; Gene Expression; Genes, fos; Humans; In Vitro Techniques; Inositol Phosphates; Lymphocyte Activation; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, Interleukin-2; Receptors, Purinergic; Receptors, Transferrin; RNA, Messenger; Second Messenger Systems; Signal Transduction; Type C Phospholipases; Tyrosine; Tyrphostins | 1992 |
Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase.
Topics: 1-Phosphatidylinositol 4-Kinase; 3T3 Cells; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Cell Transformation, Viral; Cloning, Molecular; Genes, src; Mice; Models, Biological; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Polyomavirus; Protein Conformation; Tyrosine | 1992 |
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Immunoblotting; Immunosuppressive Agents; Interleukin-2; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chromatography, Affinity; Cross-Linking Reagents; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Tyrosine | 1992 |
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cricetinae; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Signal Transduction; Tyrosine | 1992 |
Expression of human prostatic acid phosphatase activity and the growth of prostate carcinoma cells.
Topics: Acid Phosphatase; Base Sequence; Carcinoma; Cell Division; Dihydrotestosterone; DNA; Gene Expression; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Prostatic Neoplasms; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Resistance of human cervical carcinoma cells to tumor necrosis factor correlates with their increased sensitivity to cisplatin: evidence of a role for DNA repair and epidermal growth factor receptor.
Topics: Carcinoma; Cisplatin; Cross-Linking Reagents; DNA Repair; Drug Resistance; ErbB Receptors; Female; Glutathione; Humans; In Vitro Techniques; Phosphotyrosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Uterine Cervical Neoplasms | 1992 |
Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; DNA Replication; Humans; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Transfection; Tyrosine | 1992 |
Alteration of phosphotyrosine-containing proteins at the early stage of erythroid differentiation of mouse erythroleukemia (MEL) cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Electrophoresis, Polyacrylamide Gel; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sulfuric Acid Esters; Tyrosine; Vanadates | 1992 |
Evidence for association of the cloned liver growth hormone receptor with a tyrosine kinase.
Topics: 3T3 Cells; Animals; Antibodies; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Growth Hormone; Humans; L Cells; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Somatotropin; Restriction Mapping; Transfection; Tyrosine | 1992 |
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
Topics: 3T3 Cells; Animals; Blotting, Western; Kinetics; Mice; Nerve Growth Factors; PC12 Cells; Phosphates; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorus Radioisotopes; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, trkA; Signal Transduction; Transfection; Tyrosine | 1992 |
Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice.
Topics: Aging; Animals; Antibodies; Autoradiography; Blotting, Western; Concanavalin A; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocytes; Time Factors; Tyrosine | 1992 |
The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.
Topics: Animals; Antigens, CD; Calcium; Flow Cytometry; Histocompatibility Antigens; Homeostasis; Leukocyte Common Antigens; Mice; Mice, Inbred A; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Tyrosine | 1992 |
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
Topics: Animals; Blotting, Western; Enzyme Activation; Hydrogen Peroxide; Insulin; Insulin Receptor Substrate Proteins; Liver; Macromolecular Substances; Male; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine; Vanadates | 1992 |
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cytokines; Hematopoiesis; Hematopoietic Cell Growth Factors; Humans; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid, Acute; Oncogene Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins c-vav; Recombinant Proteins; Stem Cell Factor; Transfection; Tyrosine | 1992 |
Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine | 1992 |
Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells.
Topics: Amino Acid Sequence; Animals; Cytoskeletal Proteins; Humans; Lymphocyte Activation; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptors, Antigen, T-Cell; Signal Transduction; Subcellular Fractions; T-Lymphocytes; Tyrosine | 1992 |
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor.
Topics: Amino Acid Sequence; Humans; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Time Factors; Tyrosine | 1992 |
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Fungal Proteins; Genes; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Recombinant Proteins; Sequence Alignment; Tyrosine | 1992 |
Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation.
Topics: Calcium; Cell Differentiation; Enzyme Activation; Humans; In Vitro Techniques; Keratinocytes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1992 |
Continuous spectrophotometric assay of protein tyrosine phosphatase using phosphotyrosine.
Topics: Hydrogen-Ion Concentration; Phosphotyrosine; Protein Tyrosine Phosphatases; Spectrophotometry; Tyrosine | 1992 |
The sulfhydryl reagent N-ethylmaleimide induces hyperphosphorylation on tyrosine residues in the Jurkat T-cell line.
Topics: Antigens, CD; Dithiothreitol; Ethylmaleimide; Histocompatibility Antigens; Humans; Immunosorbent Techniques; Leukemia, T-Cell; Leukocyte Common Antigens; Phosphorylation; Phosphotyrosine; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1992 |
Kinase inhibition by a phosphorylated peptide corresponding to the major insulin receptor autophosphorylation domain.
Topics: Amino Acid Sequence; Binding, Competitive; Immunosorbent Techniques; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine; Vanadates | 1992 |
Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Bombesin; Cell Adhesion; Cell Adhesion Molecules; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vasopressins | 1992 |
Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
Topics: Amino Acid Sequence; Base Sequence; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Sequence Alignment; Tumor Cells, Cultured; Tyrosine | 1992 |
Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: association of a M(r) 55,000 substrate with the receptor.
Topics: Animals; Animals, Newborn; Epidermal Growth Factor; ErbB Receptors; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Signal Transduction; Tissue Distribution; Tyrosine | 1992 |
Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium; CD2 Antigens; CD3 Complex; Cells, Cultured; Child, Preschool; Gene Expression; Genes; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; Recombination, Genetic; RNA, Messenger; Signal Transduction; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 1992 |
Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Liver; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Tyrosine | 1992 |
MAP kinases: charting the regulatory pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Homeostasis; Humans; Myelin Basic Protein; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1992 |
Alterations in the subcellular distribution of p21ras-GTPase activating protein in proliferating rat acinar cells.
Topics: Animals; Cell Division; Cell Fractionation; Cell Membrane; Centrifugation, Density Gradient; Epidermal Growth Factor; Female; Golgi Apparatus; GTPase-Activating Proteins; Immunosorbent Techniques; Intracellular Membranes; Isoproterenol; Kinetics; Nuclear Envelope; Parotid Gland; Phosphorylation; Phosphotyrosine; Proteins; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Tyrosine-protein kinase inhibition in human erythrocytes by polyphosphoinositides (PIP and PIP2).
Topics: Adenosine Triphosphate; Anion Exchange Protein 1, Erythrocyte; Chymotrypsin; Erythrocytes; Humans; Hydrogen-Ion Concentration; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1992 |
Inhibition of platelet activation by tyrosine kinase inhibitors.
Topics: Catechols; Humans; Nitriles; Nitrophenols; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Thrombin; Tyrosine; Tyrphostins | 1992 |
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Epidermal Growth Factor; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Immunoblotting; Isoenzymes; Kinetics; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine | 1992 |
Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.
Topics: 3T3 Cells; Animals; Enzyme Activation; Epidermal Growth Factor; Genes, src; Immunoblotting; Insulin; Kinetics; Macromolecular Substances; Mice; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, trkA; Tyrosine | 1992 |
Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells.
Topics: Amino Acid Sequence; Animals; Blotting, Western; In Vitro Techniques; Insulin; Liver Neoplasms, Experimental; Molecular Sequence Data; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Rapid purification and N-terminal sequencing of a potato tuber cyclic nucleotide binding phosphatase.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Molecular Sequence Data; Nitrophenols; Nucleotides, Cyclic; Organophosphorus Compounds; Phosphoric Monoester Hydrolases; Phosphotyrosine; Sequence Alignment; Solanum tuberosum; Tyrosine | 1992 |
Dissociation of human cytokine receptor expression and signal transduction.
Topics: Cell Division; Dimethyl Sulfoxide; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1992 |
Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line.
Topics: Animals; B-Lymphocytes; Cell Line; Cross-Linking Reagents; DNA; Erythropoietin; Gene Expression; Immunoblotting; Interleukin-3; Kinetics; Mice; Phenylhydrazines; Phosphorylation; Phosphotyrosine; Receptors, Erythropoietin; RNA, Messenger; Signal Transduction; Transfection; Tyrosine | 1992 |
Differentiation of quail myoblasts transformed with a temperature sensitive mutant of Rous sarcoma virus. I. Relationship between differentiation and tyrosine kinase of src gene product.
Topics: Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Differentiation; Cell Fusion; Cell Line, Transformed; Coturnix; Creatine Kinase; Gene Expression; Genes, src; Lactams, Macrocyclic; Muscles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Temperature; Tyrosine | 1992 |
VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Base Sequence; Cell Cycle Proteins; Cell Line; Cloning, Molecular; DNA; Female; Fungal Proteins; Genes, myc; Humans; Methionine; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Signal Transduction; Swine; T-Lymphocytes; Tyrosine; Valosin Containing Protein | 1992 |
Solid phase synthesis of peptides containing the non-hydrolysable analog of (O)phosphotyrosine, p(CH2PO3H2)Phe. Application to the synthesis of 344-357 sequences of the beta 2 adrenergic receptor.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Hydrolysis; Molecular Sequence Data; Peptide Fragments; Peptides; Phosphorylation; Phosphotyrosine; Receptors, Adrenergic, beta; Tyrosine | 1992 |
Signal transduction by the cytoplasmic domains of Fc epsilon RI-gamma and TCR-zeta in rat basophilic leukemia cells.
Topics: Animals; Antibodies, Monoclonal; Cell Membrane; Kinetics; Leukemia, Basophilic, Acute; Macromolecular Substances; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Rats; Receptors, Antigen, T-Cell; Receptors, IgE; Recombinant Fusion Proteins; Serotonin; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
Topics: Amino Acid Sequence; Molecular Sequence Data; Oncogene Proteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-bcr; Proto-Oncogene Proteins pp60(c-src); Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1992 |
Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
Topics: Animals; Cell Division; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Kinetics; Liver; Mitogens; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Rats; Thymidine; Tyrosine | 1992 |
Association of protein-tyrosine kinase with phospholipase C-gamma 1 in bone marrow-derived mouse mast cells.
Topics: Animals; Bone Marrow Cells; Enzyme Activation; Kinetics; Macromolecular Substances; Mast Cells; Mice; Mice, Inbred CBA; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Type C Phospholipases; Tyrosine | 1992 |
Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptor.
Topics: ErbB Receptors; Kinetics; Phosphorylation; Phosphotyrosine; Protein Binding; Recombinant Fusion Proteins; Type C Phospholipases; Tyrosine | 1992 |
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.
Topics: Animals; Base Sequence; Cyclins; Cycloheximide; Enzyme Activation; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Oligodeoxyribonucleotides; Oocytes; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Tyrosine; Xenopus laevis | 1992 |
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
Topics: Base Sequence; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cyclins; Humans; Macromolecular Substances; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Schizosaccharomyces pombe Proteins; Tyrosine | 1992 |
Okadaic acid and vanadate inhibit collagen-induced platelet aggregation; the functional relation of phosphatases on platelet aggregation.
Topics: Adenosine Triphosphate; Blood Platelets; Collagen; Depression, Chemical; Ethers, Cyclic; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphotyrosine; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Phosphatase 1; Serotonin; Tyrosine; Vanadates | 1992 |
Dual effects of oleic acid on Ca2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor.
Topics: Blood Platelets; Blood Proteins; Calcium; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Kinetics; Manganese; Molecular Weight; Oleic Acid; Oleic Acids; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Aggregation; Spectrometry, Fluorescence; Tyrosine | 1992 |
Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Blotting, Western; Cell Membrane; Cytosol; Genistein; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 1992 |
Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Lymphoma, B-Cell; Mice; Molecular Sequence Data; Phorbol 12,13-Dibutyrate; Phosphotyrosine; Protein Kinase C; Proteins; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells.
Topics: Animals; B-Lymphocytes; Enzyme Activation; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
Dityrosine formation is impaired by tyrosine phosphorylation.
Topics: Alkaline Phosphatase; Antibodies, Monoclonal; Caseins; Horseradish Peroxidase; Kinetics; Phosphotyrosine; Spectrometry, Fluorescence; Tyrosine | 1992 |
Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Kinetics; Male; Molecular Weight; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Rats; Rats, Sprague-Dawley; Tyrosine | 1992 |
Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor beta chain cDNA.
Topics: Animals; Cell Differentiation; Erythropoietin; Humans; Interleukin-2; Kinetics; Leukemia, Erythroblastic, Acute; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Interleukin-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Gene Expression; Immunosorbent Techniques; Kinetics; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor, trkA; Receptors, Nerve Growth Factor; RNA; Tyrosine | 1992 |
Characterization of baculovirus-expressed human alpha and beta platelet-derived growth factor receptors.
Topics: Animals; Baculoviridae; Base Sequence; Cell Line; Gene Expression; Genetic Vectors; Humans; Immunoblotting; Molecular Sequence Data; Molecular Weight; Moths; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Transfection; Tyrosine | 1992 |
Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes.
Topics: Animals; Antibodies; Cells, Cultured; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Mice; Muscles; Phosphorylation; Phosphotransferases; Phosphotyrosine; Rats; Receptor, Insulin; Receptors, Somatomedin; Signal Transduction; Tyrosine | 1992 |
Localization of a 215-kDa tyrosine-phosphorylated protein that cross-reacts with tensin antibodies.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Adhesion Molecules; Chick Embryo; Cross Reactions; Epithelial Cells; Fibroblasts; Fluorescent Antibody Technique; Immunoblotting; Intercellular Junctions; Lens, Crystalline; Microfilament Proteins; Molecular Weight; Muscle, Smooth; Muscles; Myocardium; Myofibrils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Tensins; Tyrosine | 1992 |
The reversible and irreversible autophosphorylations of insulin receptor kinase.
Topics: Adenosine Diphosphate; Humans; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, Insulin; Thermodynamics; Tyrosine | 1992 |
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
Topics: Animals; Blotting, Western; Enzyme Activation; Insulin; Liver; Muscles; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine | 1992 |
Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo.
Topics: Animals; Chlorocebus aethiops; CHO Cells; Cricetinae; Immunologic Techniques; In Vitro Techniques; Insulin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Structure-Activity Relationship; Tyrosine | 1992 |
Expression and function of IRS-1 in insulin signal transmission.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cytoplasm; DNA; Gene Expression; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tyrosine | 1992 |
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62.
Topics: Amino Acid Sequence; Animals; Binding Sites; DNA-Binding Proteins; ErbB Receptors; GTPase-Activating Proteins; Humans; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Point Mutation; Proteins; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; Recombinant Fusion Proteins; RNA-Binding Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Tyrosine | 1992 |
Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; DNA; Enzyme Activation; Glycogen Synthase Kinase 3; Growth Hormone; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Kinases; Rats; Receptors, Somatotropin; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transfection; Tyrosine | 1992 |
Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Macrophage Colony-Stimulating Factor; Macrophages; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1992 |
Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.
Topics: Adenosine; Amino Acids; Antibodies; Antibodies, Monoclonal; Blotting, Western; CD3 Complex; Cell Line; Detergents; Humans; Kinetics; Macromolecular Substances; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Polyethylene Glycols; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Substrate Specificity; T-Lymphocytes; Tyrosine | 1992 |
Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines.
Topics: Adenosine Triphosphate; Cell Line; Cytokines; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-2; Interleukin-3; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Interferon alpha induces rapid tyrosine phosphorylation of the alpha subunit of its receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Dose-Response Relationship, Drug; Genistein; Humans; Interferon Type I; Isoflavones; Isoquinolines; Kinetics; Macromolecular Substances; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Interferon; Recombinant Proteins; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Prolactin receptor triggering. Evidence for rapid tyrosine kinase activation.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Immunoblotting; Kinetics; Membrane Proteins; Molecular Weight; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Receptors, Prolactin; Tyrosine | 1992 |
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
Topics: 3T3 Cells; Animals; Benzoquinones; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Lactams, Macrocyclic; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1992 |
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
Topics: Blood Platelets; Cell Adhesion Molecules; Collagen; Cytochalasin D; Enzyme Activation; Fibrinogen; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Thrombin; Tyrosine | 1992 |
Superantigen and HLA-DR ligation induce phospholipase-C gamma 1 activation in class II+ T cells.
Topics: Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Enterotoxins; Enzyme Activation; HLA-D Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphotyrosine; Protein-Tyrosine Kinases; Staphylococcus aureus; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1992 |
Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils.
Topics: Cell Adhesion; Chemotaxis, Leukocyte; Humans; Hydroquinones; In Vitro Techniques; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1992 |
Interleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck.
Topics: Cells, Cultured; Enzyme Activation; Humans; In Vitro Techniques; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1992 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils.
Topics: Adenosine Triphosphate; Cell Membrane Permeability; Electricity; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Magnesium; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vanadates | 1990 |
Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Humans; Immunosorbent Techniques; Insulin; Kinetics; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1990 |
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.
Topics: DNA Mutational Analysis; ErbB Receptors; Humans; In Vitro Techniques; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tyrosine | 1990 |
Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line.
Topics: Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Cell Compartmentation; Cell Line; Electrophoresis, Gel, Two-Dimensional; Humans; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; T-Lymphocytes; Tyrosine | 1990 |
Activation of human T lymphocytes via the CD2 antigen results in tyrosine phosphorylation of T cell antigen receptor zeta-chains.
Topics: Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; T-Lymphocytes; Tyrosine | 1990 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
Phosphotyrosine-containing lactate dehydrogenase is restricted to the nuclei of PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Cell Nucleus; Chromatography, Affinity; Cytoplasm; DNA-Binding Proteins; Isoenzymes; L-Lactate Dehydrogenase; Pheochromocytoma; Phosphates; Phosphorus Radioisotopes; Phosphotyrosine; Rats; Tyrosine; Vanadates | 1990 |
Glycoprotein tyrosine phosphorylation in Rous sarcoma virus-transformed chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Fibroblasts; Glycoproteins; Kinetics; Mutation; Phosphorylation; Phosphotyrosine; Tyrosine | 1990 |
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Fusion Proteins, gag-onc; GTPase-Activating Proteins; Immunosorbent Techniques; Mice; Mitosis; Molecular Weight; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Rats; Retroviridae; Tyrosine | 1990 |
Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cycloheximide; Kinetics; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Temperature; Transfection; Tyrosine; Vanadates | 1990 |
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Cell Membrane; Chromatography, Affinity; Chromatography, High Pressure Liquid; ErbB Receptors; Isoenzymes; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Type C Phospholipases; Tyrosine | 1990 |
Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Epidermal Growth Factor; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphotyrosine; Sequence Homology, Nucleic Acid; Type C Phospholipases; Tyrosine | 1990 |
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Topics: Annexins; Calcium; Calcium-Binding Proteins; Carcinoma, Squamous Cell; Cell Division; Cytoplasm; Drug Tolerance; Epidermal Growth Factor; ErbB Receptors; Humans; Mutation; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Reactivity of autoantibodies and DNA/anti-DNA complexes with a novel 110-kilodalton phosphoprotein in systemic lupus erythematosus and other diseases.
Topics: Antibodies, Antinuclear; Antigen-Antibody Complex; Autoantibodies; Autoantigens; Blotting, Western; DNA; DNA-Binding Proteins; Humans; Immunoglobulin M; Isoelectric Point; Lupus Erythematosus, Systemic; Molecular Weight; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Tyrosine | 1990 |
Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation.
Topics: Animals; Blotting, Western; Calcium; Cell Differentiation; Cytoskeleton; Cytosol; Genistein; Isoflavones; Keratinocytes; Mice; Mice, Inbred Strains; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Transglutaminases; Tyrosine | 1990 |
A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Cattle; Cell Line; Cells, Cultured; Cyanogen Bromide; Molecular Weight; Norepinephrine; Peptide Mapping; Pheochromocytoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Substrate Specificity; Tyrosine | 1990 |
Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4 Antigens; Cell Line; Enzyme Activation; Humans; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, T-Cell; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine | 1990 |
Dephosphorylation of insulin-receptor autophosphorylation sites by particulate and soluble phosphotyrosyl-protein phosphatases.
Topics: Animals; Binding Sites; Edetic Acid; Female; Humans; Kinetics; Liver; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; Serine Endopeptidases; Trypsin; Tyrosine | 1990 |
Isolation of a catalytically competent phosphorylated tyrosine kinase from Rous sarcoma virus-induced rat tumor by immunoadsorption to and hapten elution from phosphotyrosine binding antibodies.
Topics: Animals; Antibodies; Avian Sarcoma Viruses; Haptens; Histones; Immunosorbent Techniques; Neoplasms, Experimental; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Sarcoma, Avian; Tyrosine | 1990 |
An activating combination of CD2 antibodies stimulates tyrosine phosphorylation in a T lymphocyte cell line.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Cell Line; Humans; Kinetics; Molecular Weight; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; T-Lymphocytes; Tyrosine | 1990 |
Interrelationship between signals transduced by phytohemagglutinin and interleukin 1.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Carrier Proteins; Cell Line; GTP-Binding Proteins; Inositol Phosphates; Interleukin-1; Interleukin-2; Membrane Potentials; Mice; Pertussis Toxin; Phosphotyrosine; Phytohemagglutinins; Signal Transduction; Sodium-Hydrogen Exchangers; Tyrosine; Virulence Factors, Bordetella | 1990 |
Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular junction.
Topics: Animals; Diaphragm; Electric Organ; Muscles; Neuromuscular Junction; Phosphorylation; Phosphotyrosine; Rats; Receptors, Nicotinic; Torpedo; Tyrosine | 1990 |
The effect of substituting phosphotyrosine for sulphotyrosine on the activity of hirudin.
Topics: Adenosine Triphosphate; Amino Acids; Binding Sites; Chromatography, Ion Exchange; Hirudins; Humans; Kinetics; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Thrombin; Tyrosine | 1990 |
Protein tyrosine phosphorylation during meiotic divisions of starfish oocytes.
Topics: Animals; Antibodies; Cell Division; Female; Kinetics; Meiosis; Membrane Proteins; Molecular Weight; Oocytes; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Starfish; Tyrosine | 1990 |
Protein tyrosine phosphorylation associated with activation of the interleukin 2 receptor.
Topics: Adenosine Triphosphate; Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Histones; Immunosorbent Techniques; Interleukin-2; Mice; Molecular Weight; Phosphates; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Tyrosine | 1990 |
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
Topics: Animals; Avian Sarcoma Viruses; Cells, Cultured; Chick Embryo; Escherichia coli; Fibroblasts; Oncogene Protein v-crk; Oncogenes; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Retroviridae Proteins; Tyrosine | 1990 |
Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine.
Topics: Animals; Antibodies, Monoclonal; Blood Platelets; Blotting, Western; Flavonoids; Genistein; Isoflavones; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tritium; Type C Phospholipases; Tyrosine | 1990 |
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.
Topics: Animals; Cell Line; Cricetinae; In Vitro Techniques; Macromolecular Substances; Mice; Mutation; Phosphoric Monoester Hydrolases; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Type C Phospholipases; Tyrosine | 1990 |
Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Base Sequence; CD2 Antigens; Cell Division; Down-Regulation; Epitopes; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Cell Surface; Receptors, Immunologic; Recombinant Fusion Proteins; Restriction Mapping; Signal Transduction; Tyrosine | 1990 |
Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.
Topics: Animals; Blotting, Northern; Cloning, Molecular; Drosophila Proteins; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Viral; Male; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neoplasms, Experimental; Oncogenes; Pedigree; Phenotype; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Repetitive Sequences, Nucleic Acid; Restriction Mapping; RNA Probes; Tyrosine | 1990 |
High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats.
Topics: Animals; Cell Membrane; Dietary Fats; Insulin; Insulin Resistance; Kidney; Liver; Male; Muscles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1990 |
Determination of dityrosine, phosphotyrosine, phosphothreonine, and phosphoserine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Microchemistry; p-Dimethylaminoazobenzene; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Serine; Threonine; Tyrosine | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Fluorescence of phosphotyrosine--terbium(III) complexes.
Topics: In Vitro Techniques; Phosphorylation; Phosphotyrosine; Protein Binding; Spectrometry, Fluorescence; Terbium; Tyrosine | 1990 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets.
Topics: Animals; Antibodies; Blood Platelets; Enzyme Activation; Hydrolysis; Hydroquinones; In Vitro Techniques; Kinetics; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Serotonin; Tyrosine | 1990 |
Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Liver; Phosphorylation; Phosphotyrosine; Portal Vein; Proteins; Rats; Receptor, Insulin; Tyrosine | 1990 |
The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; B-Lymphocytes; Calcium; Cell Division; Cross-Linking Reagents; Dose-Response Relationship, Immunologic; Histocompatibility Antigens; HLA-D Antigens; Humans; Immunoglobulin mu-Chains; Inositol Phosphates; Interleukin-4; Leukocyte Common Antigens; Lymphocyte Activation; Palatine Tonsil; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Lipocortins are major substrates for protein kinase C in extracts of human neutrophils.
Topics: Annexins; Calcium-Binding Proteins; Cell-Free System; Humans; In Vitro Techniques; Molecular Weight; Neutrophils; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Tyrosine | 1990 |
Vasopressin dependent tyrosine phosphorylation of a 38 kDa protein in human platelets.
Topics: Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Blood Platelets; Blotting, Western; Colforsin; Dose-Response Relationship, Drug; Electrophoresis; Humans; In Vitro Techniques; Phorbol Esters; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Vasopressin; Time Factors; Tyrosine | 1990 |
A quantitative assay for tyrosine sulfation and tyrosine phosphorylation in peptides.
Topics: Chemical Phenomena; Chemistry; Peptides; Phosphotyrosine; Reference Standards; Tyrosine | 1990 |
Suramin prevents binding of interleukin 2 to its cell surface receptor: a possible mechanism for immunosuppression.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Phosphorylation; Phosphotyrosine; Receptors, Interleukin-2; Suramin; Tyrosine | 1990 |
Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromatography, DEAE-Cellulose; Culture Media; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Immunoblotting; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Denaturation; Protein Kinases; Tyrosine | 1990 |
An altered IGF-I receptor is present in human leukemic cells.
Topics: Cell Division; Cell Membrane; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Fetus; Genetic Variation; Glycosylation; Humans; Insulin; Insulin-Like Growth Factor I; Leukemia, Promyelocytic, Acute; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphothreonine; Phosphotyrosine; Receptors, Cell Surface; Receptors, Somatomedin; Somatomedins; Trypsin; Tumor Cells, Cultured; Tyrosine | 1990 |
Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Cricetinae; DNA; Enzyme Activation; Humans; Insulin; Kinetics; Phosphoric Monoester Hydrolases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1990 |
Occurrence of protein phosphorylation in various bacterial species.
Topics: Adenosine Triphosphate; Arthrobacter; Bacillus; Bacillus megaterium; Bacteria; Bacterial Proteins; Cyclic AMP; Cyclic GMP; Escherichia coli; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Pseudomonas; Tyrosine | 1990 |
Tyrosine-specific protein phosphorylation during activation of human neutrophils.
Topics: Blotting, Western; Calcimycin; Cytosol; Humans; In Vitro Techniques; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.
Topics: Animals; Brain; Brain Chemistry; Immune Sera; Male; Nerve Tissue Proteins; Organ Specificity; Phosphoproteins; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1990 |
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Mice; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Polyomavirus; Tyrosine | 1990 |
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor.
Topics: Animals; B-Lymphocytes; Humans; Immunoglobulin D; Immunoglobulin M; Immunologic Techniques; In Vitro Techniques; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tyrosine | 1990 |
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
Topics: Antibodies; Breast Neoplasms; Gene Expression; Humans; Immunoblotting; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Viral; Oncogene Protein v-crk; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Retroviridae Proteins; Signal Transduction; Tyrosine | 1990 |
Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA.
Topics: Antibodies, Monoclonal; Cell Line; DNA; Humans; Immunoblotting; Insulin; Kinetics; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Stimulation, Chemical; Transfection; Tyrosine; Wheat Germ Agglutinins | 1990 |
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation.
Topics: Animals; Avian Sarcoma Viruses; Base Sequence; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Oncogene Protein v-crk; Oncogenes; Phosphoproteins; Phosphotyrosine; Plasmids; Restriction Mapping; Retroviridae Proteins, Oncogenic; Tyrosine | 1990 |
Activation of permeabilized HL60 cells by vanadate. Evidence for divergent signalling pathways.
Topics: Actins; Adenosine Triphosphate; Amanitins; Calcium; Cell Membrane Permeability; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Immunoblotting; Leukemia, Promyelocytic, Acute; Muramidase; NADP; Neutrophils; Oxygen Consumption; Phosphotyrosine; Polymers; Signal Transduction; Thionucleotides; Tumor Cells, Cultured; Tyrosine; Vanadates | 1990 |
Phosphorylation of src-phosphopeptides by casein kinases-1 and -2: favourable effect of phosphotyrosine.
Topics: Amino Acid Sequence; Brain; Casein Kinases; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Substrate Specificity; Tyrosine | 1990 |
Epidermal growth factor induces tyrosine phosphorylation of epidermal growth factor receptors not occupied with ligand in intact A431 cells.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Ligands; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Examination of the role of serine phosphorylation in phospholipase C-gamma and its related P47 in cAMP-mediated depression of epidermal growth factor signal transduction.
Topics: Colforsin; Cross Reactions; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1990 |
Phosphorylation control by insulin in adipocytes is interfered with at a post-receptor step by phosphoinositol and glucosamine.
Topics: Adipose Tissue; Animals; Glucosamine; In Vitro Techniques; Inositol Phosphates; Insulin; Male; Oligosaccharides; Phosphorylation; Phosphotyrosine; Rats; Receptor, Insulin; Sugar Phosphates; Tyrosine | 1990 |
Phosphotyrosine-containing proteins in Dictyostelium discoideum.
Topics: Antibodies, Monoclonal; Dictyostelium; Fungal Proteins; Molecular Weight; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Tyrosine | 1990 |
Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.
Topics: Antigens, Differentiation; Cell Line; Clone Cells; Enzyme Activation; Humans; In Vitro Techniques; Interleukin-2; Interleukin-4; Killer Cells, Natural; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.
Topics: Abelson murine leukemia virus; Amino Acid Sequence; Amino Acids; Animals; Cell Line; Cell Transformation, Neoplastic; Kinetics; Leukemia Virus, Murine; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine | 1990 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Prostatic acid phosphatase in serum of patients with prostatic cancer is a specific phosphotyrosine acid phosphatase.
Topics: Acid Phosphatase; Alkaline Phosphatase; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Phosphoprotein Phosphatases; Phosphotyrosine; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Reproducibility of Results; Semen; Tyrosine | 1990 |
Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells.
Topics: Biological Transport; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1990 |
Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides.
Topics: Base Sequence; Biotin; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Molecular Structure; Oligodeoxyribonucleotides; Organophosphorus Compounds; Phosphotyrosine; Tyrosine | 1990 |
Inverse correlation between tyrosine phosphorylation and collagenase production in chondrocytes.
Topics: Animals; Blood; Cartilage, Articular; Cattle; Cell Division; Goats; Microbial Collagenase; Phosphorylation; Phosphotyrosine; Proteoglycans; Rats; Tyrosine; Vanadates | 1990 |
Phosphorylation and nuclear processing of the androgen receptor.
Topics: Androgens; Animals; Cell Nucleus; Cytosol; Isoelectric Point; Male; Phosphorylation; Phosphotyrosine; Precipitin Tests; Prostate; Rats; Receptors, Androgen; Tyrosine | 1990 |
Phosphorylated tyrosine in the flagellum filament protein of Pseudomonas aeruginosa.
Topics: Autoradiography; Bacterial Proteins; Cell Fractionation; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Flagella; Flagellin; Immunoblotting; Molecular Weight; Phosphorus Radioisotopes; Phosphotyrosine; Pseudomonas aeruginosa; Tyrosine | 1990 |
Insulin receptor is phosphorylated in response to treatment of HepG2 cells with insulin-like growth factor I.
Topics: Antibodies, Monoclonal; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Liver; Peptide Mapping; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Somatomedins; Tumor Cells, Cultured; Tyrosine | 1990 |
Tyrosine phosphorylation is an obligatory event in IL-2 secretion.
Topics: Animals; Blotting, Western; Calcium; Concanavalin A; GTP-Binding Proteins; Interleukin-2; Ionomycin; Lymphocyte Activation; Mice; Molecular Weight; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein-Tyrosine Kinases; T-Lymphocytes; Time Factors; Tyrosine; Virulence Factors, Bordetella | 1990 |
Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.
Topics: Animals; Base Sequence; Cell Compartmentation; Cell Line; Cell Membrane; DNA; DNA Mutational Analysis; Enzyme Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Molecular Sequence Data; Mutation; Myristic Acid; Myristic Acids; Oligonucleotides; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Tyrosine | 1990 |
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
Topics: Animals; Antibodies, Monoclonal; Cell Transformation, Neoplastic; Codon; DNA Mutational Analysis; Epitopes; Mice; Oncogene Proteins v-sis; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins, Oncogenic; Tyrosine | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis.
Topics: Animals; Cell Line; Enzyme Activation; Epidermal Growth Factor; Epithelium; Hydrolysis; Immunoblotting; Immunosorbent Techniques; Isoenzymes; Liver; Mice; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tyrosine | 1990 |
[Phosphoamino acid analysis by 2-dimensional electrophoresis].
Topics: Electrophoresis, Gel, Two-Dimensional; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1990 |
Elevation of cAMP, but not cGMP, inhibits thrombin-stimulated tyrosine phosphorylation in human platelets.
Topics: Blood Platelets; Bucladesine; Cyclic AMP; Cyclic GMP; Epoprostenol; Humans; Kinetics; Molecular Weight; Nitroprusside; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Thrombin; Tyrosine | 1990 |
Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.
Topics: Amino Acid Sequence; Animals; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Temperature; Tyrosine | 1990 |
A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.
Topics: Animals; Cell Line; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Insulin; Isoproterenol; Kinetics; Macromolecular Substances; Mice; Muscles; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1990 |
Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast.
Topics: CDC2 Protein Kinase; Cell Nucleus; Cyclins; Fluorescent Antibody Technique; Fungal Proteins; Mitosis; Phosphotyrosine; Schizosaccharomyces; Spindle Apparatus; Thiabendazole; Tyrosine | 1990 |
Morphological and biochemical changes in gastric mucosa of aging rats.
Topics: Aging; Animals; Atrophy; Blotting, Western; Collagen; Gastric Mucosa; Male; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Tyrosine | 1990 |
A low-molecular weight acid phosphatase present in crystalline preparations of rabbit skeletal muscle glycogen phosphorylase b.
Topics: Acid Phosphatase; Animals; Chromatography, Gel; Hydrogen-Ion Concentration; Hydrolysis; Molecular Weight; Muscles; Nitrophenols; Organophosphorus Compounds; Phosphorylase b; Phosphotyrosine; Rabbits; Substrate Specificity; Tyrosine; Vanadates; Zinc | 1990 |
Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes.
Topics: Animals; Brain; Cell Membrane; Cells, Cultured; Neurons; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Tubulin; Tyrosine | 1990 |
[The immunofluorescent detection of phosphorylated receptors of the epidermal growth factor during their internalization in A-431 cells].
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Phosphorylation; Phosphotyrosine; Staining and Labeling; Temperature; Tumor Cells, Cultured; Tyrosine | 1990 |
Activation of a membrane-associated phosphatidylinositol kinase through tyrosine-protein phosphorylation by naphthoquinones and orthovanadate.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Membrane; Chromatography, Affinity; Kinetics; Liver; Male; Naphthoquinones; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Tyrosine; Vanadates | 1990 |
Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation.
Topics: Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoenzymes; Kinetics; Phosphates; Phosphoserine; Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.
Topics: Catalysis; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Immunosorbent Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1990 |
Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.
Topics: Animals; Cell Line; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Immunosorbent Techniques; Interleukin-3; Kinetics; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine | 1990 |
Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Genes, Fungal; Glycogen Synthase Kinase 3; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Tyrosine | 1990 |
Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcimycin; Calcium; Cell Line; Epidermal Growth Factor; Ionomycin; Kinetics; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Terpenes; Thapsigargin; Tyrosine | 1990 |
No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120.
Topics: Antibodies, Monoclonal; Calcium; CD4 Antigens; CD4-Positive T-Lymphocytes; Enzyme Activation; HIV Envelope Protein gp120; HIV-1; Humans; In Vitro Techniques; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Recombinant Proteins; Signal Transduction; Time Factors; Tyrosine | 1990 |
Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src.
Topics: Animals; Cell Line; DNA Replication; Epidermal Growth Factor; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Mice; Mutation; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1990 |
Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.
Topics: Animals; Arsenicals; Cell Line; Kinetics; Lymphocyte Activation; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; T-Lymphocytes; Tyrosine | 1990 |
Basic polycations activate the insulin receptor kinase and a tightly associated serine kinase.
Topics: Animals; Cattle; Cell Membrane; Enzyme Activation; In Vitro Techniques; Liver; Macromolecular Substances; Peptides; Phosphorylation; Phosphoserine; Phosphotyrosine; Polyamines; Polyelectrolytes; Polylysine; Polymers; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Rod Cell Outer Segment; Tyrosine | 1990 |
Characterization of two tyrosine-specific protein kinases from pig spleen. Substrate-specific effect of autophosphorylation.
Topics: Animals; Chromatography, Ion Exchange; Enzyme Activation; Magnesium; Manganese; Peptides; Phosphorylation; Phosphotyrosine; Polyglutamic Acid; Polylysine; Protein-Tyrosine Kinases; Spleen; Substrate Specificity; Swine; Tyrosine | 1990 |
Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Immune Sera; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Tyrosine | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Tyrosine phosphorylation of the Fc gamma RIII(CD16): zeta complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing.
Topics: Antibody-Dependent Cell Cytotoxicity; Antigens, CD; Antigens, Differentiation; Electrophoresis, Gel, Two-Dimensional; Humans; Immunity, Cellular; Immunity, Innate; In Vitro Techniques; Killer Cells, Natural; Macromolecular Substances; Membrane Glycoproteins; Membrane Proteins; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Fc; Receptors, IgG; Tyrosine | 1991 |
A tyrosine residue in the small nuclear inclusion protein of tobacco vein mottling virus links the VPg to the viral RNA.
Topics: Amino Acid Sequence; Binding Sites; Endopeptidases; Micrococcal Nuclease; Molecular Sequence Data; Nicotiana; Phosphorylation; Phosphotyrosine; Plant Viruses; Plants, Toxic; Ribonuclease, Pancreatic; RNA, Viral; Sequence Homology, Nucleic Acid; Tyrosine; Viral Core Proteins; Viral Proteins | 1991 |
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.
Topics: Animals; Base Sequence; Cell Division; Chemotaxis; Cloning, Molecular; DNA Mutational Analysis; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1991 |
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src.
Topics: Animals; Cell Line; Enzyme Activation; Mice; Mitosis; Mutation; Peptide Mapping; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Structure-Activity Relationship; Tyrosine | 1991 |
Molecular investigations on the high-affinity nerve growth factor receptor.
Topics: Adrenal Gland Neoplasms; Affinity Labels; Animals; Antibodies, Monoclonal; Antibody Specificity; Cross-Linking Reagents; Epitopes; Humans; Immunosorbent Techniques; Macromolecular Substances; Male; Mice; Molecular Weight; Nerve Growth Factors; Pheochromocytoma; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.
Topics: Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Enzyme Activation; Fibrinogen; Humans; Immunoblotting; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Conformation; Protein-Tyrosine Kinases; Tyrosine | 1990 |
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.
Topics: Aluminum; Aluminum Compounds; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Calcium; CD40 Antigens; Cell Line; Cross-Linking Reagents; Fluorides; Genistein; Humans; Immunoglobulin M; Isoflavones; Lactams, Macrocyclic; Models, Biological; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1991 |
Electroconvulsive treatment induces a rapid and transient increase in tyrosine phosphorylation of a 40-kilodalton protein associated with microtubule-associated protein 2 kinase activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Cortex; Chromatography; Electroshock; Hippocampus; Immunosorbent Techniques; Kinetics; Male; Molecular Weight; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Signal Transduction; Tissue Distribution; Tyrosine | 1991 |
MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways.
Topics: Adipose Tissue; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Reactivators; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Xenopus | 1991 |
Association of B cell antigen receptor with protein tyrosine kinase Lyn.
Topics: Animals; B-Lymphocytes; Cell Line; Detergents; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Immunoglobulin M; Immunosorbent Techniques; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Tyrosine | 1991 |
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Topics: Animals; Blotting, Southern; Burkitt Lymphoma; Cell Division; DNA, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genetic Vectors; Humans; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1991 |
Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; In Vitro Techniques; Isoenzymes; Nerve Growth Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Type C Phospholipases; Tyrosine | 1991 |
Two-dimensional phosphopeptide analysis of the autophosphorylation cascade of a soluble insulin receptor tyrosine kinase. The tyrosines phosphorylated are typical of those observed following phosphorylation of the heterotetrameric insulin receptor in inta
Topics: Amino Acid Sequence; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Peptide Mapping; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Trypsin; Tyrosine | 1991 |
Pre-steady-state and steady-state kinetic analysis of the low molecular weight phosphotyrosyl protein phosphatase from bovine heart.
Topics: Alcohols; Animals; Binding, Competitive; Cattle; Ethylene Glycol; Ethylene Glycols; In Vitro Techniques; Kinetics; Molecular Weight; Myocardium; Nitrophenols; Organophosphorus Compounds; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Temperature; Tyrosine | 1991 |
Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Cell Line; Humans; Immunoglobulin G; Killer Cells, Natural; Ligands; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Fc; Receptors, IgG; T-Lymphocytes; Tyrosine | 1991 |
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Escherichia coli; Genes, abl; Genes, src; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins pp60(c-src); Restriction Mapping; Sequence Homology, Nucleic Acid; Tyrosine | 1991 |
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
Topics: Cell Cycle Proteins; Cyclins; Enzyme Activation; Fungal Proteins; Humans; Mitosis; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Tyrosine Phosphatases; ras-GRF1; Schizosaccharomyces; Transformation, Genetic; Tyrosine | 1990 |
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Binding Sites; Cell Line; Insecta; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1991 |
Signal transduction by HLA class II antigens expressed on activated T cells.
Topics: Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; CD4 Antigens; Cell Compartmentation; Enzyme Activation; HLA-D Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Immunologic; Signal Transduction; T-Lymphocytes; Tyrosine | 1991 |
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.
Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Gene Expression Regulation; Genes, src; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); RNA; Species Specificity; Transfection; Tyrosine | 1990 |
Expression and tyrosine phosphorylation of the T cell receptor zeta-subunit in human thymocytes.
Topics: Cell Differentiation; Child, Preschool; Humans; Membrane Glycoproteins; Membrane Proteins; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocyte Subsets; T-Lymphocytes; Thymus Gland; Tyrosine | 1991 |
Ionophore A23187-induced protein-tyrosine phosphorylation of human platelets: possible synergism between Ca2+ mobilization and protein kinase C activation.
Topics: Blood Platelets; Calcimycin; Calcium; Calcium Chloride; Egtazic Acid; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tyrosine | 1991 |
Protein tyrosine phosphatase domains from the protochordate Styela plicata.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation; Base Sequence; Biological Evolution; Caenorhabditis; Chordata, Nonvertebrate; Histocompatibility Antigens; Humans; Leukocyte Common Antigens; Molecular Sequence Data; Multigene Family; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Sequence Homology, Nucleic Acid; Tyrosine | 1991 |
Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation; Genistein; Hybridomas; Immediate-Early Proteins; In Vitro Techniques; Interleukin-6; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tristetraprolin; Tyrosine | 1991 |
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Topics: Animals; Cell Line; DNA; DNA Mutational Analysis; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, Suppressor; Ligands; Macromolecular Substances; Mice; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor Aggregation; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1991 |
Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.
Topics: Actin Cytoskeleton; Actins; Amino Acid Sequence; Cell Compartmentation; Cloning, Molecular; DNA Mutational Analysis; Enzyme Activation; Fluorescent Antibody Technique; Humans; Microfilament Proteins; Molecular Sequence Data; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-bcr; Recombinant Fusion Proteins; Restriction Mapping; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1991 |
The tumor suppressor p53 is bound to RNA by a stable covalent linkage.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Genes, Tumor Suppressor; Mice; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphotyrosine; Rats; Ribonucleoproteins; RNA; Tumor Suppressor Protein p53; Tyrosine | 1991 |
Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; DNA Mutational Analysis; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Retroviridae Proteins, Oncogenic; Structure-Activity Relationship; Tyrosine; Viral Fusion Proteins | 1991 |
Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.
Topics: Animals; Cell Line; Escherichia coli; Gene Expression; Kinetics; Macrophages; Mice; Mutagenesis, Site-Directed; Phosphates; Phosphoprotein Phosphatases; Phosphotyrosine; Plasmids; Protein Tyrosine Phosphatases; Recombination, Genetic; Restriction Mapping; Substrate Specificity; Tyrosine; Virulence; Yersinia pseudotuberculosis | 1991 |
Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.
Topics: Animals; Antibodies, Monoclonal; B-Lymphocytes; Blotting, Western; Cross-Linking Reagents; Ionomycin; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Spleen; Tyrosine | 1991 |
Tyrosine phosphorylated proteins decrease during differentiation of neuronal and glial cells.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cells, Cultured; Immunoblotting; Mice; Nerve Tissue Proteins; Neuroglia; Neurons; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Schwann Cells; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1990 |
An alternative method for a fast separation of phosphotyrosine.
Topics: Adenosine Triphosphate; Animals; Chromatography, Thin Layer; Cytidine Monophosphate; Humans; Liver; Lymphocytes; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine; Uridine Monophosphate | 1990 |
A microtiter-based assay for the detection of protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 1990 |
Synthesis of phosphotyrosyl-containing phosphopeptides by solid-phase peptide synthesis.
Topics: Alkaline Phosphatase; Amino Acids; Phosphopeptides; Phosphorylation; Phosphotyrosine; Spectrometry, Mass, Fast Atom Bombardment; Tyrosine | 1990 |
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis.
Topics: Amino Acid Sequence; Anion Exchange Protein 1, Erythrocyte; Cell Compartmentation; Diamide; Doxorubicin; Erythrocytes; Ferricyanides; Glycolysis; Humans; Hydrogen Peroxide; In Vitro Techniques; Lactates; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Tyrosine | 1991 |
Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.
Topics: B-Lymphocytes; Blotting, Western; Calcium; Cell Membrane; Cells, Cultured; Enzyme Activation; Gene Expression; Humans; In Vitro Techniques; Inositol Phosphates; Lymphocyte Activation; Palatine Tonsil; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Type C Phospholipases; Tyrosine | 1991 |
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; CD8 Antigens; Cell Line; Chimera; Cytoplasm; Humans; Inositol Phosphates; Interleukin-2; Macromolecular Substances; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Transfection; Tyrosine | 1991 |
Phosphotyrosine as a specificity determinant for casein kinase-2, a growth related Ser/Thr-specific protein kinase.
Topics: Amino Acid Sequence; Animals; Casein Kinases; Cell Division; Cytosol; Kinetics; Liver; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Substrate Specificity; Tyrosine | 1991 |
Tyrosine protein phosphorylation is required for protein kinase C-mediated proliferation in T cells.
Topics: Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Gene Expression; Humans; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Altered protein tyrosine phosphorylation in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blotting, Western; Humans; Immunohistochemistry; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Histocompatibility Antigens Class II; Hybridomas; Insulin; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mutation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Transfection; Tyrosine | 1991 |
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.
Topics: Amino Acid Sequence; Base Sequence; CDC2 Protein Kinase; Cloning, Molecular; Genes, Fungal; Mitosis; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Schizosaccharomyces; Sequence Homology, Nucleic Acid; Tyrosine | 1991 |
Cell/substratum adhesions in RSV-transformed rat fibroblasts.
Topics: Actin Cytoskeleton; Actinin; Actins; Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Transformation, Viral; Clathrin; Cytoskeletal Proteins; Fluorescent Antibody Technique; In Vitro Techniques; Intermediate Filaments; Microscopy, Electron, Scanning; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tyrosine; Vinculin | 1991 |
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression; Genes, ras; Humans; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1991 |
CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; CD4 Antigens; CD8 Antigens; Cell Differentiation; Cell Line; Cross-Linking Reagents; Female; Immune Tolerance; Mice; Mice, Inbred C57BL; Phosphotyrosine; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; Signal Transduction; T-Lymphocytes; Tyrosine | 1991 |
Genetic construction and characterization of a fusion protein consisting of a chimeric F(ab') with specificity for carcinomas and human IL-2.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antibodies, Neoplasm; Base Sequence; Carcinoma; Cloning, Molecular; Humans; Immunoglobulin Fab Fragments; Interleukin-2; Lymphocyte Activation; Molecular Sequence Data; Phosphotyrosine; Receptors, Interleukin-2; Recombinant Fusion Proteins; Restriction Mapping; Signal Transduction; T-Lymphocytes; Tyrosine | 1991 |
Identification of autophosphorylation sites of HER2/neu.
Topics: Amino Acid Sequence; Animals; DNA; ErbB Receptors; Fibroblasts; Humans; Mice; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Sequence Homology, Nucleic Acid; Signal Transduction; Transfection; Tyrosine | 1990 |
Heavy and light chain variable region sequences and antibody properties of anti-phosphotyrosine antibodies reveal both common and distinct features.
Topics: Amino Acid Sequence; Antibodies; Base Sequence; DNA; Electrophoresis, Agar Gel; Enzyme-Linked Immunosorbent Assay; Molecular Sequence Data; Phosphotyrosine; Polymerase Chain Reaction; Tyrosine | 1991 |
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.
Topics: Alkaloids; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endothelins; Glomerular Mesangium; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Substrate Specificity; Tyrosine; Vasopressins | 1991 |
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Insulin; Liver; Mice; Mice, Mutant Strains; Mice, Obese; Microscopy, Electron; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine; Vanadium | 1991 |
Phosphorylation sites of the nicotinic acetylcholine receptor. A novel site detected in position delta S362.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Activation; Phosphates; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Receptors, Nicotinic; Torpedo; Tyrosine | 1991 |
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins.
Topics: Animals; Binding Sites; Calcium; Cattle; Cell Membrane; Enzyme Activation; ErbB Receptors; GTP-Binding Proteins; Isoenzymes; Liver; Macromolecular Substances; Molecular Weight; Phosphotyrosine; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Second Messenger Systems; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.
Topics: Animals; Antigens, CD; B-Lymphocytes; CD79 Antigens; Electrophoresis, Gel, Two-Dimensional; Immunoglobulin D; Immunoglobulin M; In Vitro Techniques; Macromolecular Substances; Membrane Glycoproteins; Mice; Phosphotyrosine; Receptor Aggregation; Receptors, Antigen, B-Cell; Receptors, Fc; Signal Transduction; Tyrosine | 1991 |
Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Kinetics; Macrophage Colony-Stimulating Factor; Mice; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Tyrosine | 1991 |
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism.
Topics: Alkaloids; Calcium; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Humans; Immunoglobulin M; In Vitro Techniques; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells.
Topics: Animals; Cell Line; Cell Nucleus; DNA; Dogs; Gene Expression; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kidney; Molecular Weight; Nucleic Acid Hybridization; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Receptors, Cell Surface; Receptors, Somatomedin; RNA, Messenger; Tyrosine | 1991 |
Analysis of insulin receptor phosphorylation sites in intact rat liver cells by two-dimensional phosphopeptide mapping. Predominance of the tris-phosphorylated form of the kinase domain after stimulation by insulin.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Insulin; Liver; Male; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1991 |
Elongation factor-2 in chick embryo is phosphorylated on tyrosine as well as serine and threonine.
Topics: Age Factors; Animals; Chick Embryo; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Tyrosine | 1991 |
Cytotoxic T lymphocyte recognition of the H-2-erbB hybrid gene product lacking the complete H-2 domain structure.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Genes, Synthetic; H-2 Antigens; Mast-Cell Sarcoma; Mice; Mice, Inbred Strains; Oncogene Proteins v-erbB; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; Transfection; Tumor Cells, Cultured; Tyrosine | 1990 |
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
Topics: Animals; Base Sequence; Cell Line; Hydrolysis; Isoenzymes; Molecular Sequence Data; Mutation; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Serine; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation systems in Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Hippocampus; Humans; Immunohistochemistry; Phosphorylation; Phosphotyrosine; Tyrosine | 1991 |
Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.
Topics: B-Lymphocytes; Cell Division; Enzyme Activation; Humans; In Vitro Techniques; Inositol Phosphates; Interleukin-7; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Immunologic; Receptors, Interleukin-7; Type C Phospholipases; Tyrosine | 1991 |
Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Cloning, Molecular; In Vitro Techniques; Interleukin-2; Macromolecular Substances; Mice; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1991 |
Thymic tumorigenesis induced by overexpression of p56lck.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Gene Expression Regulation, Neoplastic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Transgenic; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; T-Lymphocyte Subsets; Thymoma; Thymus Neoplasms; Tyrosine | 1991 |
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Topics: Amino Acid Sequence; Binding Sites; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Sorting Signals; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sequence Homology, Nucleic Acid; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
Presence of an SH2 domain in the actin-binding protein tensin.
Topics: Actins; Amino Acid Sequence; Animals; Binding Sites; Chick Embryo; Cloning, Molecular; Cytoskeletal Proteins; DNA; Fluorescent Antibody Technique; Immunoblotting; Microfilament Proteins; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Nucleic Acid; Signal Transduction; Tensins; Tyrosine | 1991 |
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
Topics: Animals; Aphidicolin; CDC2 Protein Kinase; Cell Cycle; Cyclins; Diterpenes; Emetine; Fertilization; Mitosis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Sea Urchins; Time Factors; Tyrosine; Vanadates | 1991 |
The tyrosine kinase lck is critically involved in the growth transformation of human B lymphocytes.
Topics: B-Lymphocytes; Base Sequence; Blotting, Western; Cell Transformation, Viral; Gene Expression; Herpesvirus 4, Human; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Oligonucleotide Probes; Oligonucleotides, Antisense; Phosphotyrosine; Protein-Tyrosine Kinases; Time Factors; Tyrosine | 1991 |
Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation.
Topics: Animals; Cloning, Molecular; Cricetinae; DNA; In Vitro Techniques; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Tyrosine | 1991 |
Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Ethers, Cyclic; In Vitro Techniques; Insulin; Insulin Antagonists; Male; Methylglucosides; Monosaccharide Transport Proteins; Okadaic Acid; Phosphotyrosine; Rats; Tyrosine | 1991 |
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.
Topics: Animals; Catechols; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; In Vitro Techniques; Keratinocytes; Molecular Weight; Nitriles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins | 1991 |
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.
Topics: Age Factors; Animals; Cell Adhesion; Cell Communication; Cell Membrane; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; Genes, src; Liver; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Rats; src-Family Kinases; Tyrosine; Vanadates | 1991 |
Delayed thymocyte development induced by augmented expression of p56lck.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4 Antigens; CD8 Antigens; Cell Differentiation; Flow Cytometry; Gene Expression; Gene Expression Regulation; Genetic Vectors; Hematopoiesis; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Transgenic; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocyte Subsets; T-Lymphocytes; Thymus Gland; Tyrosine | 1991 |
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Escherichia coli; Female; Kinetics; Lactams, Macrocyclic; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Salmonella; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
Assessment of the in situ tyrosine kinase activity of mutant insulin receptors lacking tyrosine autophosphorylation sites 1162 and 1163.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cricetinae; Humans; Insulin; Kinetics; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1991 |
Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei.
Topics: Animals; Blotting, Western; Chromatography, Ion Exchange; Eflornithine; Electrophoresis, Polyacrylamide Gel; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Trypanosoma brucei brucei; Tyrosine; Vanadates | 1991 |
An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase.
Topics: Amino Acid Sequence; Antigens, Viral; Cell Line; Cell Transformation, Viral; Cloning, Molecular; DNA Mutational Analysis; Fluorescent Antibody Technique; Herpesvirus 4, Human; Humans; In Vitro Techniques; Membrane Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Transfection; Tyrosine; Viral Matrix Proteins; Viral Proteins | 1991 |
Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3).
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Complement C5a; Cross-Linking Reagents; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4).
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Cells, Cultured; Deoxyglucose; Glucose; Insulin; Kinetics; Macromolecular Substances; Male; Methylglucosides; Monosaccharide Transport Proteins; Muscles; Palmitic Acid; Palmitic Acids; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1991 |
Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells.
Topics: Antigens, CD; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; Cell Line; Enzyme Activation; Histocompatibility Antigens; Humans; Kinetics; Leukocyte Common Antigens; Microtubules; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine | 1991 |
Stimulation of growth of human breast cancer cells (T47D) by platelet derived growth factor.
Topics: Annexins; Antibodies; Breast Neoplasms; Calcium-Binding Proteins; Cell Division; Humans; Immunoglobulin Fab Fragments; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.
Topics: Animals; Antibodies, Monoclonal; Chick Embryo; Mutagenesis; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Sequence Homology, Nucleic Acid; Serine; Structure-Activity Relationship; Subcellular Fractions; Threonine; Tyrosine | 1991 |
Effect of genistein, a tyrosine kinase inhibitor, on latent EBV activation induced by cross-linkage of membrane IgG in Akata B cells.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Line; Cross-Linking Reagents; DNA-Binding Proteins; Gene Expression Regulation, Viral; Genistein; Herpesvirus 4, Human; Humans; Immunoglobulin G; In Vitro Techniques; Isoflavones; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Trans-Activators; Tyrosine; Viral Proteins | 1991 |
Agrin induces phosphorylation of the nicotinic acetylcholine receptor.
Topics: Agrin; Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kinetics; Macromolecular Substances; Muscles; Nerve Tissue Proteins; Phosphorylation; Phosphotyrosine; Receptors, Nicotinic; Synaptic Membranes; Tyrosine | 1991 |
Supplemental calcium suppresses colonic mucosal ornithine decarboxylase activity in elderly patients with adenomatous polyps.
Topics: Aged; Calcium; Cell Division; Colon; Humans; Intestinal Mucosa; Intestinal Polyps; Membrane Proteins; Ornithine Decarboxylase; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Insulin and insulin-like growth factors stimulate in vivo receptor autophosphorylation and tyrosine phosphorylation of a 70K substrate in cultured fetal chick neurons.
Topics: Animals; Cells, Cultured; Chick Embryo; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kinetics; Macromolecular Substances; Molecular Weight; Neurons; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Tyrosine | 1991 |
Antibodies to phosphotyrosine injected in Xenopus laevis oocytes modulate maturation induced by insulin/IGF-I.
Topics: Animals; Antibodies; Blotting, Western; Cell Cycle; Cell-Free System; Insulin; Insulin-Like Growth Factor I; Maturation-Promoting Factor; Meiosis; Oocytes; Phosphoproteins; Phosphotyrosine; Progesterone; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Somatomedin; Tyrosine; Xenopus laevis | 1991 |
Evidence for autophosphorylation of hyaluronate binding protein and its enhanced phosphorylation in rat histiocytoma.
Topics: Adenosine Triphosphate; Animals; Antibodies; Carrier Proteins; Cell Line; Electrophoresis, Polyacrylamide Gel; Fibroma; Hyaluronan Receptors; Hyaluronic Acid; Immunoblotting; Kinetics; Molecular Weight; Phosphates; Phosphorylation; Phosphotyrosine; Rats; Tyrosine | 1991 |
Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system.
Topics: Amino Acid Sequence; Antigens, Differentiation; Catalysis; Escherichia coli; Genetic Vectors; Histocompatibility Antigens; Humans; Kinetics; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Solubility; Substrate Specificity; Tyrosine | 1991 |
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
Topics: Antibodies, Monoclonal; Humans; In Vitro Techniques; Inositol Phosphates; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.
Topics: Adrenal Gland Neoplasms; Animals; Antibodies, Monoclonal; In Vitro Techniques; Nerve Growth Factors; Peptide Mapping; Pheochromocytoma; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, trkA; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites.
Topics: Amino Acid Sequence; Binding Sites; Carcinoma, Squamous Cell; Cell Membrane; Endothelial Growth Factors; Endothelium, Vascular; Humans; In Vitro Techniques; Lymphokines; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphotyrosine; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Temperature; Time Factors; Tumor Cells, Cultured; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1991 |
Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.
Topics: Animals; Macromolecular Substances; Molecular Weight; Nerve Growth Factors; Phosphoproteins; Phosphopyruvate Hydratase; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.
Topics: Animals; Baculoviridae; DNA Mutational Analysis; Enzyme Activation; Gene Expression; In Vitro Techniques; Insecta; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-bcr; Recombinant Proteins; Reticulocytes; Structure-Activity Relationship; Tyrosine | 1991 |
Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL60 cells. Role of reduced oxygen metabolites.
Topics: Granulocytes; Humans; Leukemia, Prolymphocytic; NADP; Oxygen Consumption; Phosphorylation; Phosphotyrosine; Superoxides; Tumor Cells, Cultured; Tyrosine; Vanadates; Vanadium | 1991 |
Heparin stimulates epidermal growth factor receptor-mediated phosphorylation of tyrosine and threonine residues.
Topics: Amino Acids; Animals; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Glutathione Transferase; Heparin; Humans; Insecta; Manganese; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Threonine; Tyrosine | 1991 |
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Enzyme Activation; Insulin; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Recombinant Proteins; Sequence Homology, Nucleic Acid; Tyrosine | 1991 |
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Exons; Fusion Proteins, bcr-abl; Genes, abl; Genetic Variation; Humans; Insecta; Molecular Sequence Data; Oncogene Proteins; Oncogenes; Phosphotyrosine; Plasmids; Protein Biosynthesis; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection; Tyrosine | 1991 |
Isolation and characterization of the 160,000-Da phosphotyrosyl protein, a putative participant in insulin signaling.
Topics: Adipose Tissue; Animals; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Insulin; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Tyrosine | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Recombinant human pim-1 protein exhibits serine/threonine kinase activity.
Topics: Cloning, Molecular; DNA; Escherichia coli; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Recombinant Proteins; Substrate Specificity; Tyrosine | 1991 |
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemokine CCL2; Chemotactic Factors; Cyclic AMP; DNA; Gene Expression; Genes, ras; GTP-Binding Proteins; Mice; Phosphorylation; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; rap GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells.
Topics: Antibodies, Monoclonal; Antigens, Surface; B-Lymphocytes; Cell Line; Cross-Linking Reagents; Cytoplasm; Fluorescent Antibody Technique; Genistein; Humans; Immunoglobulin G; Isoflavones; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; Tyrosine | 1991 |
Antiphosphotyrosine antibodies in oncogene and receptor research.
Topics: Animals; Antibodies, Monoclonal; Cell Line; ErbB Receptors; Humans; Immunoassay; Immunoblotting; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Tyrosine | 1991 |
Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Chromosome Deletion; Epidermal Growth Factor; ErbB Receptors; Kinetics; Membrane Potentials; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 1991 |
Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Chromatography, High Pressure Liquid; Enzyme Activation; Humans; Interleukin-2; Lymphocytes; Mice; Phosphotransferases; Phosphotyrosine; Phytohemagglutinins; Precipitin Tests; Receptors, Interleukin-2; Second Messenger Systems; Tyrosine | 1991 |
Oncogenic potential of erbB-2 in human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Gene Expression; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1991 |
Distribution and contents of free O-phosphoamino acids in animal tissues.
Topics: Animals; Brain Chemistry; Chickens; Chromatography, Gas; Fishes; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Myocardium; Organ Specificity; Phosphoserine; Phosphothreonine; Phosphotyrosine; Species Specificity; Swine; Tyrosine | 1991 |
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Chromosome Deletion; Genetic Vectors; Molecular Weight; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Receptor, trkA; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Transfection; Tyrosine | 1991 |
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Enzyme Activation; Female; Genes, src; Immunoglobulin D; Immunoglobulin M; Kinetics; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred DBA; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; Spleen; Tyrosine | 1991 |
Measurement of picomoles of phosphoamino acids by high-performance liquid chromatography.
Topics: Amino Acids; Caseins; Chromatography, High Pressure Liquid; Organophosphorus Compounds; Phosphoserine; Phosphothreonine; Phosphotyrosine; Reproducibility of Results; Serum Albumin, Bovine; Tyrosine | 1991 |
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine.
Topics: Amino Acid Sequence; Animals; Antibodies; Autoradiography; Base Sequence; Blotting, Northern; CDC2 Protein Kinase; DNA; eIF-2 Kinase; Electrophoresis, Polyacrylamide Gel; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Tyrosine | 1991 |
Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Glutamates; Glutamic Acid; Hippocampus; Immunoblotting; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 1991 |
Dephosphorylation of autophosphorylated insulin and epidermal-growth-factor receptors by two major subtypes of protein-tyrosine-phosphatase from human placenta.
Topics: Chromatography, DEAE-Cellulose; Edetic Acid; ErbB Receptors; Female; Humans; Kinetics; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Tyrosine Phosphatases; Receptor, Insulin; Tyrosine | 1991 |
Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Binding, Competitive; Cell Line; Genes, src; Immunoblotting; Isoenzymes; Kinetics; Nerve Growth Factors; Pheochromocytoma; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Receptor, trkA; Type C Phospholipases; Tyrosine | 1991 |
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1991 |
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Antigens, CD; Enzyme Activation; Histocompatibility Antigens; In Vitro Techniques; Leukocyte Common Antigens; Nerve Growth Factors; Neurons; Pheochromocytoma; Phosphoprotein Phosphatases; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Rats; Receptor, trkA; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Fibroblasts; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Molecular Weight; Myelin Basic Protein; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
MPF is activated in growing immature Xenopus oocytes in the absence of detectable tyrosine dephosphorylation of P34cdc2.
Topics: Animals; CDC2 Protein Kinase; Cyclins; Cycloheximide; Female; In Vitro Techniques; Maturation-Promoting Factor; Oocytes; Phosphotyrosine; Protamine Kinase; Tyrosine; Xenopus laevis | 1991 |
Association of p21ras with phosphatidylinositol 3-kinase.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cells, Cultured; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Liver; Phosphatidylinositols; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Tyrosine | 1991 |
Comparison of insulin receptor tyrosine phosphorylation under in vitro and in situ conditions: assessment of specific protein tyrosine phosphorylation without the use of 32P-phosphate-labeled substrates.
Topics: Antibodies; Antibody Specificity; Immunosorbent Techniques; Insulin; Iodine Radioisotopes; Phosphorylation; Phosphotyrosine; Radioimmunoassay; Receptor, Insulin; Tyrosine | 1991 |
Zn(2+)-dependent tyrosine phosphorylation of a 68-kDa protein and its differentiation from Mg(2+)-dependent tyrosine phosphorylation in sheep platelets.
Topics: Animals; Blood Platelets; Blood Proteins; Chromatography, Affinity; Chromatography, Gel; Kinetics; Magnesium; Phosphorylation; Phosphotyrosine; Polyamines; Protein-Tyrosine Kinases; Quercetin; Sheep; Tyrosine; Zinc | 1991 |
Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets.
Topics: Adenosine Diphosphate Ribose; Blood Platelets; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Humans; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Tyrosine | 1991 |
Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor.
Topics: Calcium; Genes, fos; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydrogen-Ion Concentration; Hydroquinones; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptors, Immunologic; Receptors, Leukotriene B4; RNA, Messenger; Signal Transduction; Tyrosine | 1991 |
Insulin-induced stimulation of protein phosphorylation in Neurospora crassa cells.
Topics: Antibodies; Autoradiography; Fungal Proteins; Immunosorbent Techniques; Insulin; Membrane Proteins; Neurospora crassa; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphotyrosine; Receptor, Insulin; Tyrosine | 1991 |
Fmoc/solid-phase synthesis of Tyr(P)-containing peptides through t-butyl phosphate protection.
Topics: Amino Acid Sequence; Amino Acids; Fluorenes; Molecular Sequence Data; Molecular Structure; Organophosphates; Peptides; Phosphotyrosine; Tyrosine | 1991 |
Paxillin is a major phosphotyrosine-containing protein during embryonic development.
Topics: Animals; Chick Embryo; Cytoskeletal Proteins; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Tissue Distribution; Tyrosine | 1991 |
Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.
Topics: Antigen-Antibody Complex; Cell Line; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Integrins; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Signal Transduction; Time Factors; Tyrosine | 1991 |
Characterization of a neu/c-erbB-2 protein-specific activating factor.
Topics: Cell Division; Cell Line; Down-Regulation; Enzyme Activation; Humans; Ligands; Macromolecular Substances; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; T-Lymphocytes; Tyrosine | 1991 |
Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Oncogenes; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptors, Cell Surface; Tumor Cells, Cultured; Tyrosine | 1991 |
Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Mice; Molecular Sequence Data; Molecular Weight; Myelin Basic Protein; Oligonucleotides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Polymerase Chain Reaction; Protein Kinases; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Recombinant Proteins; Tyrosine | 1991 |
Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Line; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Fc; Receptors, IgE; Receptors, Interleukin-2; Transfection; Tumor Cells, Cultured; Tyrosine | 1991 |
The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
Topics: Amino Acids; CD8 Antigens; Cell Line; Humans; Kinetics; Macromolecular Substances; Membrane Glycoproteins; Membrane Proteins; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Transfection; Tyrosine | 1991 |
Substitution of phosphotyrosine for sulphotyrosine in biologically active peptides. Enzymatic phosphorylation of a progastrin peptide confers immunoreactivity reminiscent of the sulphated derivative.
Topics: Amino Acid Sequence; Animals; Gastrins; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Precursors; Protein-Tyrosine Kinases; Radioimmunoassay; Rats; Tyrosine | 1991 |
Tyrosyl phosphorylation and activation of the myelin basic protein kinase p44mpk during sea star oocyte maturation.
Topics: Amino Acid Sequence; Animals; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glycogen Synthase Kinase 3; Immunoblotting; Kinetics; Molecular Sequence Data; Oocytes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Starfish; Tyrosine | 1991 |
Regulation of c-myc and ornithine decarboxylase expression by distinct protein kinase systems in IL-3-dependent myeloid cells.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Down-Regulation; Gene Expression; Genes, myc; Hematopoietic Stem Cells; In Vitro Techniques; Interleukin-3; Mice; Ornithine Decarboxylase; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Histochemically demonstrable phosphotyrosine protein phosphatase in the rat hippocampal formation.
Topics: Animals; Cytoplasm; Dendrites; Hippocampus; Histocytochemistry; Male; Microscopy, Electron; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Molecular Weight; Neoplasm Metastasis; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Somatomedin; Sepharose; Tyrosine | 1991 |
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.
Topics: Cell Line; Growth Substances; Hepatocyte Growth Factor; Humans; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Receptors, Cell Surface; Tyrosine | 1991 |
The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex.
Topics: Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Calcium; Enzyme Activation; Humans; Immunoglobulin M; In Vitro Techniques; Inositol Phosphates; Lymphocyte Activation; Macromolecular Substances; Molecular Weight; Phorbol Esters; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Receptors, Complement; Receptors, Complement 3d; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
Biochemical analysis of the immune B cell defect in xid mice.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Calcium; Dextrans; Female; Immunologic Deficiency Syndromes; Inositol Phosphates; Lymphocyte Activation; Male; Mice; Mice, Mutant Strains; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tyrosine | 1991 |
Generation and use of anti-phosphotyrosine antibodies for immunoblotting.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antigens; Chromatography, Affinity; Immunoblotting; Indicators and Reagents; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine | 1991 |
Sequence analysis of phosphotyrosine-containing peptides.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Indicators and Reagents; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Radioisotope Dilution Technique; Spectrophotometry, Ultraviolet; Tyrosine | 1991 |
Determination of phosphoamino acid composition by acid hydrolysis of protein blotted to Immobilon.
Topics: Amino Acids; Chromatography, Gel; Hydrolysis; Membranes, Artificial; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphotyrosine; Polyvinyls; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tyrosine | 1991 |
Synthesis of O-phosphotyrosine-containing peptides.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Tyrosine | 1991 |
Comparison of three methods for detecting tyrosine-phosphorylated proteins.
Topics: Animals; Antigen-Antibody Complex; Autoradiography; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Fibroblasts; Glycoproteins; Immunoblotting; Methionine; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tyrosine | 1991 |
Separation of phosphotyrosine, phosphoserine, and phosphothreonine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrolysis; Indicators and Reagents; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1991 |
Generation and use of anti-phosphotyrosine antibodies raised against bacterially expressed abl protein.
Topics: Animals; Antibodies; Cells, Cultured; Chromatography, Affinity; Escherichia coli; Fluorescent Antibody Technique; Genes, abl; Immunoblotting; Microscopy, Immunoelectron; Oncogene Proteins v-abl; Phosphoproteins; Phosphotyrosine; Rabbits; Recombinant Fusion Proteins; Recombinant Proteins; Tyrosine | 1991 |
Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor.
Topics: Animals; Antibodies; Cell Line; CHO Cells; Chromatography, Affinity; Cricetinae; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Indicators and Reagents; Insulin; Liver Neoplasms, Experimental; Macromolecular Substances; Molecular Weight; Neoplasm Proteins; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorus Radioisotopes; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Receptor, Insulin; Transfection; Tyrosine | 1991 |
Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Female; Haptens; Humans; Indicators and Reagents; Mice; Mice, Inbred BALB C; Molecular Weight; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Tyrosine | 1991 |
Isolation of tyrosine-phosphorylated proteins and generation of monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cells, Cultured; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Hybridomas; Indicators and Reagents; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphotyrosine; Tyrosine | 1991 |
Endogenous protein substrates for prostatic acid phosphatase in human prostate.
Topics: Acid Phosphatase; Humans; Hydrogen-Ion Concentration; Hydrolysis; Male; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prostate; Prostatic Neoplasms; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1991 |
Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
Topics: Animals; CD4 Antigens; CD8 Antigens; Cells, Cultured; Down-Regulation; Immunoblotting; Major Histocompatibility Complex; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Models, Biological; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 1991 |
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Glycolipids; Glycosylphosphatidylinositols; Humans; Membrane Glycoproteins; Membrane Proteins; Mice; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Cell Surface; Signal Transduction; Tyrosine | 1991 |
Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromatography, Affinity; ErbB Receptors; Genes, src; Humans; Kinetics; Molecular Sequence Data; Oligopeptides; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Sequence Homology, Nucleic Acid; Structure-Activity Relationship; Substrate Specificity; Type C Phospholipases; Tyrosine | 1991 |
Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product.
Topics: Blotting, Northern; Cell Division; Gene Expression; Genistein; Hematopoietic Cell Growth Factors; Humans; Immunologic Techniques; Isoflavones; Leukemia, Myeloid; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Recombinant Proteins; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1991 |
Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells.
Topics: Blotting, Northern; Blotting, Western; Cell Division; Gene Expression; Hematopoietic Cell Growth Factors; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1991 |
Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Autoradiography; Buffers; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Indicators and Reagents; Kinetics; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
Isolation of cDNA clones that encode active protein-tyrosine kinases using antibodies against phosphotyrosine.
Topics: Animals; Antibodies; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Library; Immunoblotting; Immunoglobulins; Iodine Radioisotopes; Phosphorus Radioisotopes; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Restriction Mapping; Tyrosine | 1991 |
Use of recombinant baculoviruses and 1H nuclear magnetic resonance to study tyrosine phosphorylation by a soluble insulin receptor protein-tyrosine kinase.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Genetic Vectors; Humans; Hydrogen; Insecta; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Receptor, Insulin; Substrate Specificity; Transfection; Tyrosine | 1991 |
Nonradioactive assays of protein-tyrosine kinase activity using anti-phosphotyrosine antibodies.
Topics: Antibodies; Densitometry; Immunoblotting; Indicators and Reagents; Kinetics; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat.
Topics: Animals; Brain Mapping; Brain Stem; Hippocampus; Hypothalamus; Insulin; Male; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Tyrosine | 1991 |
Myeloid differentiation associated tyrosine protein kinase activity in WEHI-3B murine monomyelocytic leukemia cells.
Topics: Animals; Cell Differentiation; Cell Division; Flow Cytometry; Immunoblotting; Kinetics; Leukemia, Myelomonocytic, Acute; Mice; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1991 |
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Chickens; Chromatography, Affinity; Chromosome Deletion; Enzyme Activation; Genes, src; Mice; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Transfection; Tyrosine | 1991 |
Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.
Topics: Amino Acid Sequence; Animals; Electric Organ; Electrophoresis, Gel, Two-Dimensional; Ion Channels; Macromolecular Substances; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Receptors, Nicotinic; Sequence Homology, Nucleic Acid; Synaptic Membranes; Torpedo; Tyrosine | 1991 |
Stimulation of tyrosine kinase activity in anti-phosphotyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antigen-Antibody Complex; Bombesin; Calcimycin; Cell-Free System; Endothelins; Gastrins; Kinetics; Mice; Molecular Sequence Data; Molecular Weight; Neuropeptides; Peptides; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine; Vanadates; Vasopressins | 1991 |
Phosphotyrosine-containing proteins in bovine chromaffin cells: effects of insulin-like growth factor I (IGF-I).
Topics: Adrenal Medulla; Animals; Cattle; Insulin-Like Growth Factor I; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Somatomedin; Tyrosine | 1991 |
Epidermal growth factor-specific protein tyrosine phosphorylation in preimplantation embryo development.
Topics: Animals; Blastocyst; Catechols; Embryonic Development; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Nitriles; Phosphorylation; Phosphotyrosine; Pregnancy; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Tyrphostins | 1991 |
Prostatic epithelial cells in culture: phosphorylation of protein tyrosyl residues and tyrosine protein kinase activity.
Topics: Animals; Cells, Cultured; Dogs; Epithelial Cells; Epithelium; Growth Substances; Magnesium; Male; Manganese; Molecular Weight; Phosphorylation; Phosphotyrosine; Prostate; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Steroids; Subcellular Fractions; Tyrosine; Vanadates | 1991 |
Role of membrane phosphotyrosine proteins in human spermatozoal function.
Topics: Antigens; Egg Proteins; Female; Humans; Male; Membrane Proteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Tyrosine; Zona Pellucida | 1991 |
Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase.
Topics: Animals; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Humans; In Vitro Techniques; Insulin; Macromolecular Substances; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1991 |
Growth signal erythropoietin activates the same tyrosine kinases as interleukin 3, but activates only one tyrosine kinase as differentiation signal.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythropoietin; Interleukin-3; Kinetics; Leukemia, Experimental; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase.
Topics: Animals; Cell Line; Enzyme Activation; Insulin; Kinetics; Liver Neoplasms, Experimental; Molecular Weight; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine; Virulence Factors, Bordetella | 1991 |
Immunodetection of the ligand-activated receptor for epidermal growth factor.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fluorescent Antibody Technique; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine | 1991 |
A rapid change in phosphorylation on tyrosine accompanies fertilization of sea urchin eggs.
Topics: Animals; Blotting, Western; Female; Fertilization; Kinetics; Male; Ovum; Phosphorylation; Phosphotyrosine; Sea Urchins; Signal Transduction; Spermatozoa; Time Factors; Tyrosine | 1991 |
A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine.
Topics: Animals; Antibodies; Kinetics; Liver; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Radioimmunoassay; Rats; Tyrosine | 1991 |
Insulin-stimulated tyrosine phosphorylation of a 43 kDa protein in rat liver membranes.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Insulin; Membrane Proteins; Microsomes, Liver; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Restriction Mapping; Serine; Tyrosine | 1991 |
Automated nonisotopic assay for protein-tyrosine kinase and protein-tyrosine phosphatase activities.
Topics: Antibodies, Monoclonal; Chromatography, Ion Exchange; Fluorescence Polarization Immunoassay; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Myelin Basic Protein; Peptides; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Naturally occurring free phosphotyrosine in human liver.
Topics: Humans; Liver; Phosphotyrosine; Tyrosine | 1991 |
Plasma desorption mass spectrometry of phosphopeptides: an investigation to determine the feasibility of quantifying the degree of phosphorylation.
Topics: Amino Acid Sequence; Mass Spectrometry; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphorylation; Phosphothreonine; Phosphotyrosine; Tyrosine | 1991 |
Tyrosine phosphorylation and immunodetection of vinculin in growth cone particle (GCP) fraction and in GCP-cytoskeletal subfractions.
Topics: Animals; Antibodies, Monoclonal; Brain; Calcium; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Fetus; Genistein; Isoflavones; Molecular Weight; Neurons; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Synaptosomes; Tyrosine; Vinculin | 1991 |
Determination of the site of tyrosine phosphorylation at the low picomole level by automated solid-phase sequence analysis.
Topics: Amino Acid Sequence; Amino Acids; Autoanalysis; Chromatography, High Pressure Liquid; Microchemistry; Peptide Mapping; Phenylthiohydantoin; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Tyrosine | 1991 |
Growth factor signal transduction in human intestinal cells.
Topics: Carcinoma; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Kinetics; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.
Topics: 3T3 Cells; Animals; Cell Adhesion; Fibronectins; Fluorescent Antibody Technique; Integrins; Mice; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; Time Factors; Tyrosine | 1991 |
[The direct demonstration of the tyrosine phosphorylation of epidermal growth factor receptors internalized in the endosomes of A431 cells].
Topics: Antibodies; Carcinoma, Squamous Cell; Cell Fractionation; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Organelles; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1991 |
Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells.
Topics: Animals; Carcinoma; Culture Media; Epidermal Growth Factor; ErbB Receptors; Female; Growth Substances; Mammary Neoplasms, Experimental; Neoplasm Proteins; Phenotype; Phosphoproteins; Phosphotyrosine; Rats; Tyrosine | 1991 |
Demonstration of separate phosphotyrosyl- and phosphoseryl- histone phosphatase activities in the plasma membranes of a human astrocytoma.
Topics: 4-Nitrophenylphosphatase; Astrocytoma; Cell Line; Cell Membrane; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Diphosphates; Histones; Humans; Hydrolysis; In Vitro Techniques; Nitrophenols; Nucleotides; Organophosphorus Compounds; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphotyrosine; Tissue Distribution; Tyrosine; Vanadates; Vanadium | 1985 |
Purification and properties of a quinone-dependent p-nitrophenylphosphatase from Clostridium sticklandii.
Topics: 4-Nitrophenylphosphatase; Adenosine Diphosphate; Adenosine Monophosphate; Amino Acids; Benzoquinones; Chromatography, Affinity; Chromatography, Gel; Clostridium; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Molecular Weight; Phosphoric Monoester Hydrolases; Phosphotyrosine; Quinones; Time Factors; Tyrosine | 1985 |
Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins.
Topics: Animals; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Deoxyglucose; Kinetics; Mice; Moloney murine sarcoma virus; Phosphatidylinositols; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphotyrosine; Rats; Tyrosine; Vanadates; Vanadium; Zinc | 1985 |
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.
Topics: Animals; Autoradiography; Calcium; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Time Factors; Tyrosine | 1985 |
Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane.
Topics: Caseins; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Hydrogen-Ion Concentration; Membrane Proteins; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Tyrosine | 1985 |
Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Chromosomes, Human, 6-12 and X; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Humans; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Receptors, Cell Surface; RNA, Messenger; RNA, Neoplasm; Translocation, Genetic; Tyrosine | 1985 |
The phosphoform of the regulatory subunit RII of cyclic AMP-dependent protein kinase possesses intrinsic topoisomerase activity.
Topics: Animals; Bacteriophage phi X 174; Cyclic AMP; DNA Topoisomerases, Type I; DNA, Superhelical; DNA, Viral; Edetic Acid; Kinetics; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein Kinases; Rats; Tyrosine | 1985 |
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Transformation, Viral; Enzyme Activation; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine; Vanadates; Vanadium; Viral Proteins | 1985 |
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes.
Topics: Actins; Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Transformation, Viral; Cricetinae; Cytoskeletal Proteins; Fibroblasts; Microscopy, Electron; Muscle Proteins; Phosphotyrosine; Tyrosine; Vinculin | 1985 |
Immunofluorescent staining of human leukemic cells with monoclonal antibody to phosphotyrosine.
Topics: Antibodies, Monoclonal; Bone Marrow Cells; Cell Line; Fluorescent Antibody Technique; Humans; Leukemia; Phosphotyrosine; Tyrosine | 1985 |
Partial purification and characterization of a pp60v-src-related tyrosine kinase from bovine brain.
Topics: Adenosine Triphosphate; Animals; Avian Sarcoma Viruses; Brain; Cattle; Cerebral Cortex; Immunoglobulin G; Manganese; Molecular Weight; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Protein Conformation; Protein Kinases; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine; Viral Proteins | 1985 |
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor.
Topics: Dithiothreitol; Enzyme Activation; Female; Humans; Insulin; Macromolecular Substances; Male; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Structure-Activity Relationship; Tyrosine | 1985 |
A simple and rapid method of quantitative analysis of phosphoamino acids by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1985 |
Observation of tyrosine-O-phosphate in Drosophila melanogaster larvae by 31P-NMR spectroscopy.
Topics: Animals; Drosophila melanogaster; Hydrogen-Ion Concentration; Larva; Magnetic Resonance Spectroscopy; Phosphates; Phosphotyrosine; Tyrosine | 1985 |
Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Line; Cytoskeleton; Epidermal Growth Factor; ErbB Receptors; Humans; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cell Surface; Tyrosine | 1985 |
Inhibition of epidermal growth factor-induced phosphorylation by trifluoperazine.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Chlorpromazine; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Imipramine; Mice; Microscopy, Electron, Scanning; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Sulfonamides; Trifluoperazine; Tyrosine | 1985 |
Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chick Embryo; Cytoskeleton; Dogs; Epithelium; Fibroblasts; Fluorescent Antibody Technique; Intercellular Junctions; Macropodidae; Mice; Organ Specificity; Phosphoproteins; Phosphotyrosine; Rats; Species Specificity; Tyrosine | 1985 |
Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies.
Topics: Animals; Antibodies; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Female; Humans; Mathematics; Phosphotyrosine; Placenta; Pregnancy; Protein Kinases; Rabbits; Receptor, Insulin; Tyrosine | 1985 |
Phosphorylation of p36 in vitro with pp60src. Regulation by Ca2+ and phospholipid.
Topics: Animals; Annexins; Calcium; Cattle; Intestines; Kinetics; Membrane Proteins; Oncogene Protein pp60(v-src); Phosphatidylinositols; Phosphatidylserines; Phospholipids; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine | 1985 |
Tyrosine phosphorylation of a 94-kDa protein of human fibroblasts stimulated by streptococcal lipoteichoic acid.
Topics: Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Lipopolysaccharides; Phosphates; Phosphatidic Acids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Streptococcus pyogenes; Teichoic Acids; Tyrosine | 1985 |
Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product.
Topics: Cell Line; Fibroblasts; Glioma; Humans; Neoplasm Proteins; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Transcription, Genetic; Tyrosine | 1985 |
Rabbit antibodies with specificity for tyrosine phosphate are not reactive with tyrosine sulphate.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Enzyme-Linked Immunosorbent Assay; Immune Sera; Kinetics; Phosphotyrosine; Rabbits; Tyrosine | 1985 |
Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin.
Topics: Alkaline Phosphatase; Animals; Calmodulin-Binding Proteins; Cattle; Escherichia coli; Hydrolysis; Kinetics; Molecular Weight; Phosphoric Monoester Hydrolases; Phosphotyrosine; Substrate Specificity; Tyrosine | 1985 |
Anti-O-phosphotyrosine antibodies in human sera.
Topics: Adolescent; Adult; Aged; Antibodies; Antibody Affinity; Child; Child, Preschool; Collagen Diseases; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infant; Infant, Newborn; Liver Diseases; Lung Diseases; Male; Middle Aged; Neoplasms; Nervous System Diseases; Phosphotyrosine; Tyrosine | 1985 |
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Enzyme Activation; Mice; Mitosis; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1985 |
Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100.
Topics: Amino Acid Sequence; Animals; Calcium-Binding Proteins; Cattle; Cell Compartmentation; Cytoskeletal Proteins; Intestines; Macromolecular Substances; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; S100 Proteins; Tyrosine | 1985 |
Biochemical characterization of two Epstein-Barr virus early antigen-associated phosphopolypeptides.
Topics: Antibodies, Monoclonal; Antigens, Viral; Cell Line; Chromatin; DNA; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Molecular Weight; Phosphopeptides; Phosphoserine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine; Viral Proteins | 1985 |
Rapid separation of phosphoamino acids including the phosphohistidines by isocratic high-performance liquid chromatography of the orthophthalaldehyde derivatives.
Topics: Aldehydes; Amino Acids; Arginine; Buffers; Chromatography, High Pressure Liquid; Histidine; o-Phthalaldehyde; Organophosphorus Compounds; Phosphoserine; Phosphothreonine; Phosphotyrosine; Temperature; Tyrosine | 1985 |
Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone.
Topics: Brain; Calmodulin-Binding Proteins; Cations, Monovalent; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptors, Cell Surface; Tyrosine | 1985 |
Direct identification of phosphotyrosine-containing proteins in some retrovirus-transformed cells by use of anti-phosphotyrosine antibody.
Topics: Animals; Antibodies; Antibody Specificity; B-Lymphocytes; Cell Transformation, Viral; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae; Tyrosine | 1986 |
Protein-tyrosine kinase activity in Saccharomyces cerevisiae.
Topics: Intercellular Signaling Peptides and Proteins; Kinetics; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Tyrosine | 1986 |
Increase of phosphotyrosine-containing proteins in human carcinomas.
Topics: Carcinoma; Carcinoma, Hepatocellular; Chromatography, Affinity; Esophageal Neoplasms; Fluorescent Antibody Technique; Humans; Liver Neoplasms; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Stomach Neoplasms; Tissue Distribution; Tyrosine | 1985 |
Phosphorylation of proteins in Clostridium thermohydrosulfuricum.
Topics: Bacterial Proteins; Calmodulin; Cell-Free System; Clostridium; Hexosephosphates; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyamines; Subcellular Fractions; Tyrosine | 1986 |
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: Amino Acids; Animals; Carcinoma, Squamous Cell; Cattle; Cell Division; Cell Line; Depression, Chemical; Dogs; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Humans; Immunosorbent Techniques; Mice; Mouth Neoplasms; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.
Topics: Animals; Carrier Proteins; Cell Line; Cytoskeletal Proteins; Fluorescent Antibody Technique; Humans; Isoelectric Point; Microfilament Proteins; Microvilli; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Tissue Distribution; Tyrosine | 1986 |
Tyrosine phosphorylation of platelet protein induced by phorbol ester.
Topics: Animals; Blood Platelets; Enzyme Activation; Kinetics; Microscopy, Electron; Microscopy, Electron, Scanning; Molecular Weight; Phorbols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Phosphotyrosine as a substrate of acid and alkaline phosphatases.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Cattle; Escherichia coli; Humans; Hydrogen-Ion Concentration; Hydrolysis; Intestines; Kinetics; Male; Phosphotyrosine; Prostate; Spectrophotometry, Ultraviolet; Tyrosine | 1985 |
The human red cell acid phosphatase is a phosphotyrosine protein phosphatase which dephosphorylates the membrane protein band 3.
Topics: Acid Phosphatase; Anion Exchange Protein 1, Erythrocyte; Cytosol; Erythrocytes; Humans; Phosphoprotein Phosphatases; Phosphotyrosine; Tyrosine | 1986 |
In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies.
Topics: Adenosine Triphosphate; Animals; Antibodies; Cadaverine; Chloroquine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Immunologic Techniques; Methylamines; Mice; Molecular Weight; Phenylglyoxal; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1986 |
Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.
Topics: Animals; Avian Sarcoma Viruses; Binding Sites; Biological Transport; Cell Membrane; Cell Transformation, Viral; Macromolecular Substances; Molecular Weight; Mutation; Myristates; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine | 1986 |
The viral tyrosine protein kinases.
Topics: Abelson murine leukemia virus; Animals; Avian Sarcoma Viruses; Cell Compartmentation; Cell Transformation, Viral; ErbB Receptors; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Retroviridae; Retroviridae Proteins; Substrate Specificity; Tyrosine | 1986 |
Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Cell Line; Colforsin; Cyclic AMP; Lymphocytes; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Receptor, Insulin; Time Factors; Tyrosine | 1986 |
Protein phosphorylation at tyrosine residues in v-abl transformed mouse lymphocytes and fibroblasts.
Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Chemical Precipitation; Fibroblasts; Lymphocytes; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Proteins, Viral; Oncogenes; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Tyrosine | 1986 |
Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunologic Techniques; Immunosorbent Techniques; Lymphoma; Mice; Molecular Weight; Phorbols; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Phosphotyrosine-containing 120,000-dalton protein coimmunoprecipitated with pp60v-src from Rous sarcoma virus-transformed mammalian cells.
Topics: Animals; Arvicolinae; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Chemical Precipitation; Chick Embryo; Epitopes; Immune Sera; Mice; Molecular Weight; Muscle Proteins; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphoserine; Phosphotyrosine; Retroviridae Proteins; Tyrosine; Vinculin | 1986 |
Complement-mediated lysis of K562 human leukemic cells by antibodies to phosphotyrosine and identification of cell surface proteins phosphorylated on tyrosine.
Topics: Antibodies, Monoclonal; Cell Line; Cell Membrane; Complement System Proteins; Cytotoxicity, Immunologic; Fluorescent Antibody Technique; Humans; Leukemia; Membrane Proteins; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Tyrosine | 1986 |
Evidence of the activity of tyrosine kinase(s) and of the presence of phosphotyrosine proteins in pea plantlets.
Topics: Chromatography, High Pressure Liquid; Phosphorylation; Phosphotyrosine; Plant Proteins; Plants; Protein-Tyrosine Kinases; Tyrosine | 1986 |
Characterization of the monomeric and complex-associated forms of the gag-onc fusion proteins of three isolates of feline sarcoma virus: phosphorylation, kinase activity, acylation, and kinetics of complex formation.
Topics: Acylation; Animals; Cats; Cells, Cultured; Fibroblasts; Gene Products, gag; Kinetics; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae; Retroviridae Proteins; Sarcoma Viruses, Feline; Tyrosine | 1986 |
Characterization of the phosphorylatable myosin light chain in rat uterus.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Female; Isoelectric Point; Molecular Weight; Myosins; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Tyrosine; Uterus | 1986 |
The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.
Topics: Adenosine Triphosphate; Adipose Tissue; Angiotensin II; Animals; Cell Membrane; Insulin-Like Growth Factor II; Kinetics; Male; Molecular Weight; Phosphorus Radioisotopes; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatomedin; Somatomedins; Tyrosine | 1986 |
Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chickens; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins; Species Specificity; Tyrosine; Vanadium | 1986 |
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
Phosphorylation of tyrosine residues of calmodulin in Rous sarcoma virus-transformed cells.
Topics: Animals; Avian Sarcoma Viruses; Calmodulin; Cell Transformation, Viral; Chick Embryo; In Vitro Techniques; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine | 1986 |
PDGF-induced receptor phosphorylation and phosphoinositide hydrolysis are unaffected by protein kinase C activation in mouse Swiss 3T3 and human skin fibroblasts.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Humans; Mice; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Partial purification and characterization of phosphotyrosyl-protein phosphatase(s) from human erythrocyte cytosol.
Topics: 4-Nitrophenylphosphatase; Chromatography, DEAE-Cellulose; Erythrocytes; Humans; Phosphoprotein Phosphatases; Phosphotyrosine; Substrate Specificity; Tyrosine | 1986 |
Epidermal growth factor receptor kinase translocation and activation in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Golgi Apparatus; Kinetics; Liver; Male; Microscopy, Electron; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Tyrosine | 1986 |
The conversion of native adenylylated glutamine synthetase into phosphotyrosine enzyme by micrococcal nuclease.
Topics: Adenosine Monophosphate; Catalysis; Glutamate-Ammonia Ligase; Hydrogen-Ion Concentration; Micrococcal Nuclease; Mycobacterium; Phosphotyrosine; Tyrosine | 1986 |
Immunochemical recognition of phosphate ester derivatives of phenol rings is dependent upon the electronic charge of the ester group.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Antigen-Antibody Complex; Arylsulfotransferase; Cattle; Enzyme-Linked Immunosorbent Assay; Esters; Helix, Snails; Immune Sera; Intestines; Kinetics; Male; Phenols; Phosphoric Acids; Phosphotyrosine; Prostate; Sulfurtransferases; Tyrosine | 1986 |
The interaction with PDGF as a source of G1 phase heterogeneity in normal mouse fibroblasts.
Topics: Animals; Cell Cycle; Cell Transformation, Viral; Culture Media; Fibroblasts; Interphase; Mice; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Simian virus 40; Tyrosine | 1986 |
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases.
Topics: Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Growth Substances; Mice; Mice, Inbred BALB C; Molecular Weight; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins; Tyrosine | 1986 |
Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.
Topics: Amino Acid Sequence; Animals; Brain; Calmodulin; Cattle; Fluorides; Kinetics; Manganese; Myocardium; Myosins; Nickel; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphotyrosine; Protein Tyrosine Phosphatases; Serine; Tyrosine; Vanadates; Vanadium; Zinc | 1986 |
Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein.
Topics: Animals; Bone Marrow; Cell Line; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leukemia; Mice; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tyrosine | 1985 |
Structural and functional modification of pp60c-src associated with polyoma middle tumor antigen from infected or transformed cells.
Topics: Amino Acid Sequence; Animals; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Viral; Mice; Peptide Fragments; Phosphorylation; Phosphotyrosine; Polyomavirus; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1985 |
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.
Topics: Adenosine Triphosphate; Animals; Cell Line; Chickens; Guanosine Triphosphate; Immunoglobulin G; In Vitro Techniques; Isoelectric Point; Mice; Molecular Weight; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins; Substrate Specificity; Tyrosine | 1985 |
Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Immunologic Techniques; Muscle Proteins; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Talin; Tyrosine; Vinculin | 1986 |
Endogenous phosphorylation of proteins and phosphatidylinositol in the plasma membranes of a human astrocytoma.
Topics: Adenosine Triphosphate; Astrocytoma; Cations, Divalent; Cell Membrane; Detergents; Humans; Membrane Proteins; Neoplasm Proteins; Phosphatidylinositols; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1986 |
Purification and autophosphorylation of insulin receptors from rat skeletal muscle.
Topics: Age Factors; Animals; Animals, Newborn; Diaphragm; Molecular Weight; Muscles; Phosphorylation; Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1986 |
Regulation of the phosphorylation state and function of the epidermal growth factor receptor by vitamin K-3.
Topics: Calcium; Cells, Cultured; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine; Vitamin K | 1986 |
The FLP recombinase of the Saccharomyces cerevisiae 2 microns plasmid attaches covalently to DNA via a phosphotyrosyl linkage.
Topics: Base Sequence; Chromosome Deletion; DNA Nucleotidyltransferases; DNA Restriction Enzymes; DNA, Fungal; Hydrolysis; Phosphotyrosine; Plasmids; Protein Binding; Saccharomyces cerevisiae; Tyrosine | 1985 |
Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein.
Topics: Animals; Antibodies; Cell Transformation, Neoplastic; Chromatography, Affinity; Immunization; Oncogene Proteins, Viral; Phosphotyrosine; Tyrosine | 1985 |
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor.
Topics: Animals; Antigens; Isoelectric Point; Lymphocyte Activation; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Distinct specificities of repressible acid phosphatase from yeast toward phosphoseryl and phosphotyrosyl phosphopeptides.
Topics: Acid Phosphatase; Amino Acid Sequence; Isoenzymes; Kinetics; Phosphoproteins; Phosphoserine; Phosphotyrosine; Saccharomyces cerevisiae; Substrate Specificity; Tyrosine | 1986 |
Tyrosine phosphorylation in cells treated with transforming growth factor-beta.
Topics: Animals; Cell Line; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Peptides; Phosphorylation; Phosphotyrosine; Rats; Transforming Growth Factors; Tyrosine | 1986 |
Autophosphorylation and kinase activity of insulin receptor in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Insulin; Liver; Male; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1986 |
Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells.
Topics: Cell Differentiation; Cell Line; Granulocytes; Humans; Leukemia, Myeloid, Acute; Monocytes; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1986 |
The tyrosine phosphorylation substrate p36 is developmentally regulated in embryonic avian limb and is induced in cell culture.
Topics: Age Factors; Animals; Cell Adhesion; Cells, Cultured; Chick Embryo; Extremities; Gene Expression Regulation; Immunologic Techniques; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1986 |
Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Viral; Enzyme Activation; ErbB Receptors; Growth Substances; Humans; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vaccinia virus; Viral Proteins | 1986 |
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells.
Topics: Amino Acids; Antibodies; Antigen-Antibody Complex; Bone Marrow; Cell Line; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Neoplasm Proteins; Phosphorus Radioisotopes; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Reference Values; Tyrosine | 1986 |
Resolution and identification of O-phosphoserine, O-phosphothreonine, O-phosphotyrosine, and gamma-carboxyglutamic acid as their fluorescent o-phthalaldehyde derivatives by high performance liquid chromatography.
Topics: 1-Carboxyglutamic Acid; Animals; Chromatography, High Pressure Liquid; Fluorescent Dyes; o-Phthalaldehyde; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1986 |
Estradiol receptor: phosphorylation on tyrosine in uterus and interaction with anti-phosphotyrosine antibody.
Topics: Animals; Antibodies, Monoclonal; Cytosol; Estradiol; Female; Phosphates; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptors, Estradiol; Receptors, Estrogen; Tyrosine; Uterus | 1986 |
Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.
Topics: Animals; Bombesin; Cells, Cultured; Gastrin-Releasing Peptide; Growth Substances; Kinetics; Mice; Mitogens; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Receptor for bombesin with associated tyrosine kinase activity.
Topics: Amino Acids; Animals; Antigen-Antibody Complex; Bombesin; Cells, Cultured; Immune Sera; Kinetics; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Neurotransmitter; Tyrosine | 1986 |
gp140v-fms molecules expressed at the surface of cells transformed by the McDonough strain of feline sarcoma virus are phosphorylated in tyrosine and serine.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Genes; Genes, Viral; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Retroviridae; Retroviridae Proteins; Serine; Tyrosine; Vanadates; Vanadium | 1986 |
Separation and quantitative analysis of O-linked phosphoamino acids by isocratic high-performance liquid chromatography of the 9-fluorenylmethyl chloroformate derivatives.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Fluorenes; Ion Exchange Resins; Organophosphorus Compounds; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1986 |
Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.
Topics: Animals; Cell Line; Dogs; Immunosorbent Techniques; Insulin-Like Growth Factor I; Kidney; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptor, Insulin; Receptors, Somatomedin; Somatomedins; Tyrosine | 1987 |
Histone phosphorylation in explants of mouse mammary glands and tumors.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Histones; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1986 |
Two classes of phosphotyrosine-containing proteins detected by labeling with 32P and 125I in HeLa cells.
Topics: Fluorescent Antibody Technique; HeLa Cells; Humans; Iodine Radioisotopes; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Tyrosine | 1987 |
Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients.
Topics: Amino Acids; Antigen-Antibody Complex; Blast Crisis; Cell Line; Humans; Leukemia, Myeloid; Molecular Weight; Peptide Mapping; Philadelphia Chromosome; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tyrosine | 1987 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase.
Topics: Animals; Carrier Proteins; Cattle; Chromatography, High Pressure Liquid; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Myocardium; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain.
Topics: Amino Acids; Animals; Brain; Cell Membrane; Insulin; Insulin-Like Growth Factor I; Kinetics; Liver; Lizards; Macromolecular Substances; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Somatomedins; Tyrosine | 1987 |
Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase.
Topics: Adenosine Triphosphate; Animals; Bisphosphoglycerate Mutase; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glycolysis; Insulin; Kinetics; L-Lactate Dehydrogenase; Phosphofructokinase-1; Phosphoproteins; Phosphopyruvate Hydratase; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine | 1987 |
Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.
Topics: Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Calcium; Cell Compartmentation; Cell Line; Cytoplasm; Humans; Interleukin-2; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tyrosine | 1987 |
Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor.
Topics: Antigens, Viral, Tumor; Cell Transformation, Viral; Immunosorbent Techniques; Molecular Weight; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Polyomavirus; Protein Tyrosine Phosphatases; Tyrosine; Vanadium | 1987 |
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Transformation, Neoplastic; Cells, Cultured; DNA Restriction Enzymes; Escherichia coli; Genes; Mice; Mutation; Oncogenes; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Temperature; Tyrosine | 1987 |
Proteins phosphorylated on tyrosine as markers of human tumor cell lines.
Topics: Cell Line; ErbB Receptors; Humans; Molecular Weight; Neoplasm Proteins; Neoplasms; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Tyrosine phosphorylation of an interleukin 2 receptor-like protein in cells transformed by human T cell leukemia virus type I.
Topics: Antibodies, Monoclonal; Cell Line; Cell Transformation, Viral; Deltaretrovirus; Humans; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tyrosine | 1987 |
Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.
Topics: Animals; Antibodies, Monoclonal; Arvicolinae; Avian Sarcoma Viruses; Cell Transformation, Viral; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine; Vanadium | 1987 |
Use of electroblotting to detect and analyze phosphotyrosine containing peptides separated by two-dimensional gel electrophoresis.
Topics: Animals; Cells, Cultured; Collodion; Electrophoresis, Polyacrylamide Gel; Nylons; Peptides; Phosphotyrosine; Sodium Hydroxide; Tyrosine | 1987 |
A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene.
Topics: Epidermal Growth Factor; Glycoproteins; Humans; KB Cells; Molecular Weight; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogenes; Tyrosine | 1987 |
Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product.
Topics: Abelson murine leukemia virus; Animals; B-Lymphocytes; Cell Differentiation; Gene Expression Regulation; Immunoglobulin gamma-Chains; Immunoglobulin mu-Chains; Mice; Oncogene Proteins, Viral; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Recombination, Genetic; RNA, Messenger; Tyrosine | 1987 |
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor I; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Receptors, Somatomedin; Somatomedins; Tyrosine | 1987 |
Insulin stimulates the tyrosine phosphorylation of a Mr = 160,000 glycoprotein in rat adipocyte plasma membranes.
Topics: Adipose Tissue; Animals; Cell Membrane; Glycoproteins; In Vitro Techniques; Insulin; Kinetics; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine | 1987 |
Insulin stimulates a membrane-bound serine kinase that may be phosphorylated on tyrosine.
Topics: Adipose Tissue; Animals; Antibodies; Antigen-Antibody Complex; Insulin; Kinetics; Male; Microsomes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Tyrosine | 1987 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
Vanadate stimulation of phosphotyrosine protein levels in quiescent Nakano mouse lens cells.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Lens, Crystalline; Mice; Mice, Inbred Strains; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Subcellular Fractions; Time Factors; Tyrosine; Vanadates; Vanadium | 1987 |
Characterization of an endogenous substrate of the insulin receptor in cultured cells.
Topics: Animals; Cell Line; Cloning, Molecular; Humans; Insulin; Liver Neoplasms, Experimental; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1987 |
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
Topics: Animals; Cell Division; Cell Line; DNA Replication; Humans; Insulin-Like Growth Factor I; Mice; Mice, Inbred BALB C; Mitosis; Oncogenes; Osteosarcoma; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Tyrosine | 1987 |
Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues.
Topics: Amino Acid Sequence; Blast Crisis; Blood Proteins; Cell Line; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid; Leukocytes; Neoplasm Proteins; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Recombinant Proteins; Tyrosine | 1987 |
Characterization of avian and viral p60src proteins expressed in yeast.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Chick Embryo; Chickens; Fibroblasts; Fungal Proteins; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Recombinant Proteins; Retroviridae Proteins; Saccharomyces cerevisiae; Tyrosine | 1987 |
Reduction in protein tyrosine phosphorylation during differentiation of human leukemia cell line K-562.
Topics: Cell Differentiation; Cell Line; Hemin; Leukemia, Myeloid; Neoplasm Proteins; Neoplastic Stem Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Tyrosine | 1987 |
The quantity of protein-bound [32P]phosphotyrosine in hepatocytes and fibroblasts. The effects of tyrosine protein kinase activating agents.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Liver; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Phosphotyrosine phosphatase: a novel phosphatase specific for phosphotyrosine, 2'-AMP and p-nitrophenylphosphate in rat brain.
Topics: Adenosine Monophosphate; Animals; Brain; Brain Chemistry; Cations, Divalent; Chromatography; Hydrogen-Ion Concentration; Isoelectric Focusing; Molecular Weight; Nitrophenols; Organophosphorus Compounds; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Substrate Specificity; Tyrosine | 1987 |
Characterization of phosphate residues on thyroglobulin.
Topics: Animals; Carbohydrates; Cattle; Cell Line; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Mannose; Methionine; Phosphates; Phosphoserine; Phosphotyrosine; Pronase; Rats; Rats, Inbred F344; Thyroglobulin; Thyroid Gland; Tunicamycin; Tyrosine | 1987 |
Alteration of protein phosphorylation patterns in cell lines morphologically transformed by human cytomegalovirus.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cytomegalovirus; Humans; Isoelectric Point; Membrane Proteins; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Kinases; Spermidine; Tyrosine | 1987 |
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.
Topics: Adenosine Triphosphate; Allosteric Site; Animals; Chickens; Fibroblasts; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Saccharomyces cerevisiae; Tyrosine | 1987 |
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Gene Expression Regulation; Mice; Mice, Inbred BALB C; Oncogene Protein gp140(v-fms); Oncogene Proteins v-sis; Oncogene Proteins, Viral; Oncogenes; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Polyomavirus; Protein-Tyrosine Kinases; Retroviridae Proteins; Simian virus 40; Substrate Specificity; Tyrosine | 1987 |
An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antigen-Antibody Complex; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Fibroblasts; Mice; Mice, Inbred BALB C; Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Polyomavirus; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1987 |
Demonstration that LSTRA cells have an elevated level of proteins phosphorylated on tyrosine residues.
Topics: Cell Line; Humans; Immune Sera; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1987 |
T cell antigen receptor phosphorylation induced by an anti-receptor antibody.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Antigens; Antigens, Differentiation, T-Lymphocyte; Inositol Phosphates; Interleukin-2; Isoelectric Point; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine | 1987 |
Phosphorylation of the lysosomal enzyme binding receptor protein from monkey brain and evidence for a tyrosine kinase activity associated with it.
Topics: Animals; Brain; Carrier Proteins; Histones; Intracellular Membranes; Lysosomes; Membrane Proteins; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, IGF Type 2; Tyrosine | 1987 |
Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): detection by using an immunoblotting technique.
Topics: Humans; Immunosorbent Techniques; Leukemia, Myeloid; Molecular Weight; Neoplasm Proteins; Philadelphia Chromosome; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1987 |
Analysis of tyrosine kinase activity in cell extracts using nondenaturing polyacrylamide gel electrophoresis.
Topics: Adenosine Triphosphate; Cell Line; Chromatography; Electrophoresis, Polyacrylamide Gel; Granulocytes; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Leukemia, Myeloid; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis.
Topics: Aluminum; Cyclic AMP; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Lymphocyte Activation; Lymphocytes; Phosphatidylinositols; Phospholipases A; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Thionucleotides; Type C Phospholipases; Tyrosine | 1987 |
gp140, the EBV/C3d receptor (CR2) of human B lymphocytes, is involved in cell-free phosphorylation of p120, a nuclear ribonucleoprotein.
Topics: B-Lymphocytes; Cell Nucleus; Herpesvirus 4, Human; Humans; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Precursors; Receptors, Complement; Receptors, Complement 3d; Receptors, Virus; Ribonucleoproteins; Tumor Cells, Cultured; Tyrosine | 1987 |
Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.
Topics: Animals; Cell Line; Fibroblast Growth Factors; Immune Sera; Immunosorbent Techniques; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Suramin; Temperature; Tyrosine | 1988 |
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells.
Topics: Amino Acids; Antibodies; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Kinetics; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Trypsin; Tyrosine | 1987 |
Phosphorylation on tyrosine of oestradiol-17 beta receptor in uterus and interaction of oestradiol-17 beta and glucocorticoid receptors with antiphosphotyrosine antibodies.
Topics: Animals; Antibodies, Monoclonal; Cattle; Cell Nucleus; Female; Male; Organ Specificity; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptors, Estradiol; Receptors, Estrogen; Receptors, Glucocorticoid; Tyrosine; Uterus | 1987 |
Tyrosine phosphorylations in vivo associated with v-fms transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Glycoproteins; Immunologic Techniques; Mice; Mink; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retroviridae Proteins; Structure-Activity Relationship; Tyrosine | 1988 |
The stereospecificity of protein kinases.
Topics: Blood Proteins; Erythrocytes; Humans; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Kinases; Stereoisomerism; Substrate Specificity; Tyrosine | 1987 |
Analysis of pp60c-src tyrosine kinase activity and phosphotyrosyl phosphatase activity in human colon carcinoma and normal human colon mucosal cells.
Topics: Adenocarcinoma; Buffers; Cells, Cultured; Colonic Neoplasms; Humans; Immunologic Techniques; Intestinal Mucosa; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine; Vanadates | 1987 |
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
Topics: Antibodies; Binding Sites; Enzyme Activation; Humans; Insulin; Macromolecular Substances; Peptide Mapping; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Receptor, Insulin; Tyrosine | 1988 |
Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli.
Topics: Catalysis; Cloning, Molecular; DNA Mutational Analysis; Escherichia coli; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Sarcoma Viruses, Murine; Structure-Activity Relationship; Tyrosine; Viral Fusion Proteins | 1987 |
Localization of high concentrations of phosphotyrosine-modified proteins in mouse megakaryocytes.
Topics: Animals; Female; Immunologic Techniques; Megakaryocytes; Membrane Proteins; Mice; Mice, Inbred BALB C; Microscopy, Electron; Osmolar Concentration; Phosphotyrosine; Staining and Labeling; Tyrosine | 1988 |
Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Ligands; Macromolecular Substances; Microinjections; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1988 |
A novel viral oncogene with structural similarity to phospholipase C.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Brain; Cattle; Cloning, Molecular; DNA, Recombinant; DNA, Viral; Genes, Viral; Immunosorbent Techniques; Molecular Sequence Data; Oncogenes; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Nucleic Acid; Type C Phospholipases; Tyrosine | 1988 |
Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas.
Topics: Animals; Bombesin; Carcinoma, Small Cell; Cell Line; Enzyme Activation; Fibroblasts; Humans; Lung Neoplasms; Membrane Proteins; Mice; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Bombesin; Receptors, Neurotransmitter; Tumor Cells, Cultured; Tyrosine | 1988 |
Secretion of high and low molecular weight phosphorylated apolipoprotein B by hepatocytes from control and diabetic rats. Phosphorylation of APO BH and APO BL.
Topics: Animals; Apolipoproteins B; Cells, Cultured; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Liver; Male; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system.
Topics: Chromatography; Cytoplasm; DNA, Recombinant; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Immunosorbent Techniques; Insect Viruses; Macromolecular Substances; Manganese; Molecular Weight; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Trypsin; Tyrosine | 1988 |
Nonmyristoylated p60v-src fails to phosphorylate proteins of 115-120 kDa in chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Immunosorbent Techniques; Membrane Proteins; Molecular Weight; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Retroviridae Proteins; Structure-Activity Relationship; Subcellular Fractions; Tyrosine | 1988 |
Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.
Topics: Animals; Cell Line; Immunoassay; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1988 |
Monoclonal antibodies to phosphotyrosine.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Fusion; Cell Line; Enzyme-Linked Immunosorbent Assay; Humans; Phosphotyrosine; Tyrosine | 1988 |
Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.
Topics: Animals; Antibodies; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Oncogene Proteins, Viral; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine | 1988 |
Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A.
Topics: Animals; Arvicolinae; Benzoquinones; Cell Line; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Lactams, Macrocyclic; Mice; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1988 |
A major site of tyrosine phosphorylation within the SH2 domain of Fujinami sarcoma virus P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; DNA Mutational Analysis; Gene Expression Regulation; Oncogene Proteins, Viral; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Structure-Activity Relationship; Tyrosine; Viral Fusion Proteins | 1988 |
Appearance of antibodies against phosphotyrosine and tyrosine phosphorylation of lymphocyte proteins in human T cell leukemia virus type-I infection.
Topics: Antibody Formation; Deltaretrovirus Infections; Humans; Lymphocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine | 1988 |
Tyrosine phosphorylated proteins in different tissues during chick embryo development.
Topics: Animals; Antibodies; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Immunoassay; Integrins; Membrane Glycoproteins; Muscle Proteins; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine; Vinculin | 1988 |
Phosphotyrosine-modified proteins are concentrated at the membranes of epithelial and endothelial cells during tissue development in chick embryos.
Topics: Animals; Antibodies; Cell Membrane; Chick Embryo; Endothelium; Epithelium; Fluorescent Antibody Technique; Immunohistochemistry; Microscopy, Electron; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine | 1988 |
Biosynthesis of the epidermal growth factor receptor: post-translational glycosylation-independent acquisition of tyrosine kinase autophosphorylation activity.
Topics: Adenosine Triphosphate; Antibodies; Cell Line; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Glycosylation; Humans; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Tunicamycin; Tyrosine | 1988 |
Purification and properties of an acid phosphoprotein phosphatase from lactating bovine mammary gland with activity toward phosphotyrosine.
Topics: Acid Phosphatase; Animals; Cattle; Female; Lactation; Mammary Glands, Animal; Phosphoprotein Phosphatases; Phosphotyrosine; Pregnancy; Tyrosine | 1988 |
Dissociation of the ligand and dephosphorylation of the platelet-derived growth factor receptor.
Topics: Animals; Cells, Cultured; Kinetics; Mice; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1988 |
Biochemical characterization of tyrosine kinase and phosphotyrosine phosphatase activities of HL-60 leukemia cells.
Topics: Adenosine Triphosphate; Cations, Divalent; Cell Line; Ethylmaleimide; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Peptides; Phosphoprotein Phosphatases; Phosphotyrosine; Polymers; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1988 |
Immunological characterization of proteins detected by phosphotyrosine antibodies in cells transformed by Rous sarcoma virus.
Topics: Annexins; Avian Sarcoma Viruses; Calcium-Binding Proteins; Cell Line; Cell Transformation, Viral; Cytoskeletal Proteins; Molecular Weight; Muscle Proteins; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Receptors, Fibronectin; Receptors, Immunologic; Retroviridae Proteins; Tyrosine; Vinculin | 1988 |
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Electrophoresis, Polyacrylamide Gel; HIV; Humans; Hydrogen-Ion Concentration; Immunosorbent Techniques; Lymphocyte Activation; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Virus; T-Lymphocytes; Tyrosine | 1988 |
The high molecular weight and the low molecular weight acid phosphatases of the frog liver and their phosphotyrosine activity.
Topics: Acid Phosphatase; Animals; Chromatography, Affinity; Chromatography, Gel; Dithiothreitol; Isoenzymes; Kinetics; Liver; Molecular Weight; Phosphotyrosine; Rana esculenta; Tyrosine | 1988 |
Vanadate-treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their Rous sarcoma virus-transformed counterparts.
Topics: Actin Cytoskeleton; Animals; Avian Sarcoma Viruses; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cricetinae; Cytoskeleton; Fibroblasts; Kidney; Phenotype; Phosphoproteins; Phosphotyrosine; Tyrosine; Vanadates | 1988 |
Zn2+ enhances protein tyrosine kinase activity of human platelet membranes.
Topics: Blood Platelets; Cations, Divalent; Cell Membrane; Humans; Magnesium; Manganese; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tyrosine; Zinc | 1988 |
Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.
Topics: Adenosine Triphosphate; Animals; Annexins; Calcium; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Immunosorbent Techniques; Insulin; Liver; Male; Manganese; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Recombinant Proteins; Tyrosine | 1988 |
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
Topics: Antibodies; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Cytosol; Epidermal Growth Factor; Hydrolysis; Inositol Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1988 |
Nerve growth factor induces protein-tyrosine phosphorylation.
Topics: Adrenal Gland Neoplasms; Animals; Bucladesine; Cell Line; Epidermal Growth Factor; Immunosorbent Techniques; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tyrosine | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.
Topics: Adenosine Triphosphate; Adipose Tissue; Arsenicals; Cell Line; Deoxyglucose; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Insulin; Kinetics; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Trypsin; Tyrosine; Vanadates | 1988 |
Protein tyrosine phosphorylation in response to fertilization.
Topics: Adenosine Triphosphate; Animals; Centrifugation, Density Gradient; Egg Proteins; Electrophoresis, Polyacrylamide Gel; Female; Fertilization; Immunoassay; Immunosorbent Techniques; Molecular Weight; Ovum; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Sea Urchins; Tyrosine | 1988 |
Determination of [32P]phosphoamino acids in protein hydrolysates by isocratic anion-exchange high-performance liquid chromatography.
Topics: Buffers; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Serine; Spectrophotometry, Ultraviolet; Threonine; Tyrosine | 1988 |
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Topics: Animals; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fasting; Insulin; Liver; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1988 |
Comparative study of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents.
Topics: Animals; Cell Division; Cell Line; Fibroblasts; Fluorescent Antibody Technique; Immunoblotting; Mitogens; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine | 1988 |
Phosphorylation of tyrosine enhances its electron transfer capability: a model of redox modulation as oncogene expression?
Topics: Electron Transport; Ferrous Compounds; Models, Chemical; Nitroblue Tetrazolium; Oxidation-Reduction; Phosphorylation; Phosphotyrosine; Tyrosine | 1988 |
Regulation by the autophosphorylation site in overexpressed pp60c-src.
Topics: Animals; Mice; Mutation; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Structure-Activity Relationship; Tyrosine; Vanadium | 1988 |
Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.
Topics: Affinity Labels; Animals; Cell Differentiation; Cell Division; Cell Line; Interleukin-3; Molecular Weight; Phosphotyrosine; Receptors, Immunologic; Receptors, Interleukin-3; Tyrosine | 1988 |
Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1.
Topics: Animals; Colony-Stimulating Factors; Macrophages; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; Subcellular Fractions; Temperature; Tyrosine | 1988 |
Characterization of a high-molecular-weight protein immunoprecipitated by platelet-derived growth factor antisera.
Topics: Cell Line; Cross Reactions; Epidermal Growth Factor; Humans; Immune Sera; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1988 |
Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.
Topics: Animals; Antibodies, Monoclonal; Bone Marrow Cells; Cell Line; Interleukin-3; Phosphorylation; Phosphotyrosine; Tyrosine | 1988 |
CD15 monoclonal antibodies react with a phosphotyrosine-containing protein on the surface of human neutrophils.
Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; Humans; Lewis X Antigen; Membrane Proteins; Molecular Weight; Neutrophils; Oligosaccharides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Tyrosine | 1988 |
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
Topics: Alleles; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; DNA, Viral; L Cells; Molecular Sequence Data; Mutation; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Substrate Specificity; Tyrosine | 1989 |
Human insulin receptors expressed in insulin-insensitive mouse fibroblasts couple with extant cellular effector systems to confer insulin sensitivity and responsiveness.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Cell Line; DNA; Fibroblasts; Glucose; Glycogen; Humans; Insulin; Mice; Phosphotyrosine; Receptor, Insulin; Transfection; Tyrosine | 1989 |
The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation.
Topics: Adipose Tissue; Animals; Immunoblotting; Insulin; Isoproterenol; Lipolysis; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine; Vanadates | 1989 |
Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Immunosorbent Techniques; Kinetics; Oncogene Protein pp60(v-src); Phosphoenolpyruvate; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvate Kinase; Retroviridae Proteins; Tyrosine | 1988 |
Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.
Topics: Animals; Cell Line; DNA; Electrophoresis, Gel, Two-Dimensional; Humans; In Vitro Techniques; Isoelectric Point; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Tyrosine | 1988 |
Platelet-derived growth factor induces phosphorylation of a 64-kDa nuclear protein.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Nuclear Proteins; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Subcellular Fractions; Sulfur Radioisotopes; Tyrosine | 1989 |
Characterization of partially activated p60c-src in chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Enzyme Activation; Extracellular Matrix; Fibroblasts; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Retroviridae Proteins; Tyrosine | 1989 |
Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies.
Topics: Animals; Antibodies; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Kinetics; Mutation; Oncogenes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Tyrosine | 1988 |
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.
Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Line; Cell Transformation, Neoplastic; Herbicides; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retroviridae Proteins; Rifabutin; Thermodynamics; Tyrosine | 1989 |
Reversibility of the epidermal growth factor receptor self-phosphorylation reaction. Evidence for formation of a high energy phosphotyrosine bond.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Cell Line; Dose-Response Relationship, Drug; ErbB Receptors; Humans; Kinetics; Phosphorylation; Phosphotyrosine; Thermodynamics; Tyrosine | 1989 |
Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.
Topics: Algorithms; Animals; Cell Line; Insulin; Liver Neoplasms, Experimental; Models, Biological; Phosphorylation; Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1989 |
Regulation of biosynthesis and phosphorylation of P210bcr/abl protein during differentiation induction of K 562 cells.
Topics: Cell Differentiation; Cell Fractionation; Cell Line; Growth Substances; Humans; Immune Sera; Leukemia, Erythroblastic, Acute; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; Tyrosine | 1988 |
The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Cell Communication; Cell Line; Cell Membrane; ErbB Receptors; Intracellular Membranes; Microsomes; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Plasmids; Protein Precursors; Signal Transduction; Transfection; Transforming Growth Factor alpha; Transforming Growth Factors; Tyrosine | 1989 |
Characterization of sites of serine phosphorylation in human placental insulin receptor copurified with insulin-stimulated serine kinase activity by two-dimensional thin-layer peptide mapping.
Topics: Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Insulin; Serine; Tyrosine | 1989 |
Nucleotidylation, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria.
Topics: Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Glutamate-Ammonia Ligase; Hydrolysis; Molecular Weight; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Radioisotope Dilution Technique; Salmonella typhimurium; Species Specificity; Tyrosine | 1989 |
Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.
Topics: Adult; Amino Acids; Blood Platelets; Humans; Kinetics; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Thrombin; Trypsin; Tyrosine | 1988 |
Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Transfection; Tyrosine | 1988 |
Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.
Topics: Cell Line; ErbB Receptors; Humans; Immunoblotting; Ligands; Osmolar Concentration; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Salts; Sodium Chloride; Tyrosine | 1989 |
Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.
Topics: Animals; Blood Platelets; Cell Line; Humans; Immunoblotting; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1989 |
Characterization and partial purification of a high-molecular-mass, calmodulin-binding, tyrosyl-phosphorylated protein from lymphocyte plasma membranes.
Topics: Animals; Calmodulin; Calmodulin-Binding Proteins; Concanavalin A; Humans; Lymphocyte Activation; Lymphocytes; Membrane Proteins; Molecular Weight; Muscle Proteins; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Serine Endopeptidases; Tyrosine; Vinculin | 1989 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations.
Topics: Adipose Tissue; Adult; Aged; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Insulin; Middle Aged; Obesity; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1989 |
Most of the substrates of oncogenic viral tyrosine protein kinases can be phosphorylated by cellular tyrosine protein kinases in normal cells.
Topics: Animals; Antigens, Polyomavirus Transforming; Avian Sarcoma Viruses; Blotting, Western; Cell Line; Cell Transformation, Viral; Mice; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Proto-Oncogenes; Rats; Retroviridae Proteins; Substrate Specificity; Tyrosine | 1988 |
Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor.
Topics: Animals; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Diphosphate; Humans; Hydrogen-Ion Concentration; Insulin; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine | 1989 |
Serine and tyrosine phosphorylation of 28- and 35-kDa proteins of human T lymphocytes stimulated by streptococcal M protein.
Topics: Antigens, Bacterial; Antigens, Differentiation, T-Lymphocyte; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Humans; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Phytohemagglutinins; Serine; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tyrosine | 1989 |
Autoantibodies to the insulin receptor (B-10) can stimulate tyrosine phosphorylation of the beta-subunit of the insulin receptor and a 185,000 molecular weight protein in rat hepatoma cells.
Topics: Adipose Tissue; Animals; Autoantibodies; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Immunoglobulin G; Insulin; Liver Neoplasms, Experimental; Molecular Weight; Neoplasm Proteins; Peptide Hydrolases; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine | 1989 |
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Bradykinin; Calcium; Cell Line; Epidermal Growth Factor; ErbB Receptors; Immunoassay; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Type C Phospholipases; Tyrosine | 1989 |
Role of phosphatidylinositol kinase in PDGF receptor signal transduction.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Line; Chromatography; Cricetinae; Immunoassay; Immunosorbent Techniques; Mice; Mice, Inbred BALB C; Mutation; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tyrosine | 1989 |
In the absence of antibody IgGsorb precipitates human placenta phosphotyrosine-containing proteins.
Topics: Cell Membrane; Female; Humans; Immunoglobulin G; Immunosorbent Techniques; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Receptor, Insulin; Staphylococcal Protein A; Tyrosine | 1989 |
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat.
Topics: Calcium; Cell Line; Diglycerides; Enzyme Activation; Humans; Immunoblotting; Molecular Weight; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
Effects of vanadate on tyrosine phosphorylation and the pattern of glycosaminoglycan synthesis in rabbit chondrocytes in culture.
Topics: Animals; Cartilage; Chondroitin Sulfate Proteoglycans; Disaccharides; Dose-Response Relationship, Drug; Glucosamine; Glycosaminoglycans; Hyaluronic Acid; In Vitro Techniques; Male; Phosphotyrosine; Rabbits; Tyrosine; Vanadium | 1989 |
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Calcium; Gene Expression Regulation; Humans; Inositol Phosphates; Mitosis; Muscle, Smooth, Vascular; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1989 |
Analysis of the activity and phosphorylation of the lck protein in lymphoid cells.
Topics: Animals; Blotting, Western; Cell Line; Electrophoresis, Gel, Two-Dimensional; Isoelectric Point; Lymphocytes; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Mesocricetus; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Tyrosine | 1989 |
Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Glycosylation; Integrins; Membrane Glycoproteins; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Trypsin; Tunicamycin; Tyrosine | 1989 |
Mitogen-mediated protein phosphorylation in Werner's syndrome fibroblasts.
Topics: Adult; Cell Division; DNA; Fibroblasts; Humans; Male; Mitogens; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine; Werner Syndrome | 1988 |
Interleukin 3 and phorbol ester stimulate tyrosine phosphorylation of overlapping substrate proteins.
Topics: Animals; Cell Line; Electrophoresis, Gel, Two-Dimensional; Interleukin-3; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Phosphorylation of the insulin receptor in permeabilized adipocytes is coupled to a rapid dephosphorylation reaction.
Topics: Adipose Tissue; Animals; Cell Membrane; Digitonin; Insulin; Kinetics; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine; Vanadates | 1989 |
Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system.
Topics: Animals; Antigen-Antibody Reactions; Cell-Free System; Electrophoresis, Gel, Two-Dimensional; Insulin; Liver Neoplasms, Experimental; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Time Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets.
Topics: Antibodies, Monoclonal; Blood Platelets; Blotting, Western; Collagen; Humans; In Vitro Techniques; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Serotonin; Thrombin; Time Factors; Tyrosine | 1989 |
Phosphotyrosyl-protein phosphatases. I. Separation of multiple forms from bovine brain and purification of the major form to near homogeneity.
Topics: Alkaline Phosphatase; Animals; Brain; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Isoenzymes; Molecular Weight; Phosphoprotein Phosphatases; Phosphotyrosine; Substrate Specificity; Tyrosine | 1989 |
Phosphotyrosyl-protein phosphatases. II. Identification and characterization of two heat-stable protein inhibitors.
Topics: Animals; Brain; Cattle; Hot Temperature; Kinetics; Molecular Weight; Phosphoprotein Phosphatases; Phosphotyrosine; Protease Inhibitors; Protein Phosphatase 1; Tyrosine | 1989 |
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.
Topics: Amino Acid Sequence; Antibodies; Base Sequence; DNA; Humans; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Nucleic Acid; Tyrosine | 1988 |
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.
Topics: Animals; Cells, Cultured; Genetic Variation; Histocytochemistry; Molecular Weight; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Transformation, Genetic; Tyrosine | 1989 |
Phosphorylation status of nuclear and cytosolic androgen receptors in the rat ventral prostate.
Topics: Animals; Antibodies; Cytosol; Male; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Prostate; Rats; Rats, Inbred Strains; Receptors, Androgen; Tyrosine | 1989 |
rp-120: a common endogenous substrate for insulin and IGF-1 receptor-associated tyrosine kinase activity in the highly malignant AS-30D rat hepatoma cells.
Topics: Animals; Female; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor I; Liver Neoplasms, Experimental; Membrane Glycoproteins; Microsomes, Liver; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Tumor Cells, Cultured; Tyrosine | 1989 |
High pp60c-src level in human platelet dense bodies.
Topics: Blood Platelets; Cytoplasmic Granules; Humans; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Tyrosine | 1989 |
Identification of tyrosine-phosphorylated colony-stimulating factor 1 (CSF-1) receptor and a 56-kilodalton protein phosphorylated in intact human cells in response to CSF-1.
Topics: Cells, Cultured; Colony-Stimulating Factors; Electrophoresis, Polyacrylamide Gel; Macrophage Colony-Stimulating Factor; Phosphorus Radioisotopes; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; Sodium Dodecyl Sulfate; Tyrosine | 1989 |
Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Membrane; Culture Media; Fibroblasts; Genes, ras; Hematopoietic Stem Cells; Humans; Mitogens; Mitosis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured; Tyrosine | 1989 |
Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Biological Transport; Dinitrophenols; Immunosorbent Techniques; Insulin; Iodine Radioisotopes; Liver Neoplasms, Experimental; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine; Uncoupling Agents | 1989 |
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.
Topics: Antigens, Differentiation, T-Lymphocyte; Catalysis; CD3 Complex; CD8 Antigens; Cell Line, Transformed; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Immunosorbent Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine | 1989 |
Identification of a protein cross-reacting with anti-phosphotyrosine antibodies in yeast insoluble cytoplasmic matrices.
Topics: Antibodies, Fungal; Antibody Specificity; Cell Fractionation; Cross Reactions; Cytoplasm; Fungal Proteins; Molecular Weight; Octoxynol; Phosphotyrosine; Polyethylene Glycols; Saccharomyces cerevisiae; Solubility; Tyrosine | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.
Topics: Amiloride; Botulinum Toxins; Cell Membrane; Cholera Toxin; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Molecular Weight; Neutrophils; Pertussis Toxin; Phosphates; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Sodium; Tyrosine; Virulence Factors, Bordetella | 1989 |
Differential effects of PDGF and PDGF-BB on vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Blood Platelets; Cattle; DNA; Humans; Immunosorbent Techniques; Macromolecular Substances; Membrane Proteins; Molecular Weight; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Radioligand Assay; Recombinant Proteins; Tyrosine | 1989 |
Immunoaffinity purification of tyrosine-phosphorylated cellular proteins.
Topics: Animals; Chickens; Chromatography, Affinity; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Rats; Tyrosine | 1989 |
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Topics: Antineoplastic Agents; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Tyrphostins | 1989 |
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro.
Topics: Animals; Blotting, Western; Cell Line; ErbB Receptors; Humans; Mice; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Time Factors; Type C Phospholipases; Tyrosine | 1989 |
95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding.
Topics: Acrosome; Animals; Antibodies, Monoclonal; Blotting, Western; Egg Proteins; Fluorescent Antibody Technique; Glycoproteins; In Vitro Techniques; Male; Membrane Glycoproteins; Mice; Molecular Weight; Ovum; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Spermatozoa; Tyrosine; Zona Pellucida; Zona Pellucida Glycoproteins | 1989 |
o-Phosphotyrosyl glutamine synthetase: modification of the nucleotide ligation site of adenylylated glutamine synthetase.
Topics: Adenosine; Alkaline Phosphatase; Escherichia coli; Glutamate-Ammonia Ligase; Micrococcal Nuclease; Mycobacterium; Phosphotyrosine; Tyrosine | 1989 |
Heat shock induces protein tyrosine phosphorylation in cultured cells.
Topics: Animals; Cell Line; Chickens; Cycloheximide; Fluorescent Antibody Technique; Hot Temperature; Immunoblotting; Mammals; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vanadium | 1989 |
Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Blotting, Western; Cell Transformation, Viral; Chick Embryo; Cytoskeletal Proteins; Fluorescent Antibody Technique; Molecular Weight; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Evidence that a phosphotyrosine-containing 120,000 Da protein from Rous sarcoma virus-infected cells is phosphorylated by pp60v-src.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae Proteins; Tyrosine | 1989 |
Thin-layer chromatography can resolve phosphotyrosine, phosphoserine, and phosphothreonine in a protein hydrolyzate.
Topics: Animals; Autoradiography; Chromatography, Thin Layer; Humans; Hydrolysis; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1989 |
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Calcium; Casein Kinases; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphotyrosine; Protein Kinase C; Protein Kinases; Temperature; Tumor Cells, Cultured; Tyrosine | 1989 |
Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Chick Embryo; Chickens; Cloning, Molecular; DNA; Filaggrin Proteins; Immunoblotting; Molecular Sequence Data; Molecular Weight; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Nucleic Acid; Tyrosine | 1989 |
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase.
Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cell-Free System; Enzyme Activation; Mitosis; Molecular Weight; Oocytes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Saccharomycetales; Schizosaccharomyces; Tyrosine; Xenopus laevis | 1989 |
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis.
Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Enzyme Activation; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protamine Kinase; Structure-Activity Relationship; Time Factors; Tyrosine; Vanadates | 1989 |
Phosphotyrosine phosphatase activity prevents the detection of P210bcr/abl protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique.
Topics: Blast Crisis; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Weight; Neoplasm Proteins; Neutrophils; Peptide Hydrolases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Insulin receptor dephosphorylation in permeabilized adipocytes is inhibitable by manganese and independent of receptor kinase activity.
Topics: Adipose Tissue; Animals; Cations, Divalent; Cells, Cultured; In Vitro Techniques; Insulin; Manganese; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tyrosine | 1989 |
Inhibition by lysosomal enzymes and mannose-6-phosphate of the phosphorylation of the lysosomal enzyme binding receptor protein from monkey brain.
Topics: alpha-L-Fucosidase; Animals; Brain; Butyrylcholinesterase; Glucuronidase; Haplorhini; Hexosephosphates; Histones; Insulin-Like Growth Factor II; Intracellular Membranes; Lysosomes; Mannosephosphates; Molecular Weight; Phosphorylation; Phosphotyrosine; Receptor, IGF Type 2; Receptors, Cell Surface; Receptors, Somatomedin; Tyrosine | 1989 |
Tyrosine phosphorylation in human neutrophil.
Topics: Cinnamates; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; In Vitro Techniques; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Sulfides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor.
Topics: Animals; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Insect Viruses; Mice; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Transfection; Tyrosine | 1989 |
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Chick Embryo; Enzyme Activation; Molecular Weight; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Retroviridae Proteins; Transformation, Genetic; Tyrosine | 1989 |
Phosphorylation of tyrosine prevents dityrosine formation in vitro.
Topics: Alkaline Phosphatase; Chemical Phenomena; Chemistry; Horseradish Peroxidase; Kinetics; Phosphorylation; Phosphotyrosine; Tyrosine | 1989 |
The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.
Topics: Cell Line, Transformed; Cross-Linking Reagents; Humans; Immunoblotting; Molecular Weight; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Tyrosine | 1989 |
Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; CD8 Antigens; Cell Differentiation; Mice; Mice, Inbred Strains; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Thymus Gland; Time Factors; Tyrosine | 1989 |
Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane; Enzyme Activation; Insulin; Liver; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Purification and characterization of a phosphotyrosyl-protein phosphatase from wheat seedlings.
Topics: Caseins; Chelating Agents; Chemical Phenomena; Chemistry, Physical; Chromatography; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Metals; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Plants; Protein Tyrosine Phosphatases; Substrate Specificity; Triticum; Tyrosine | 1989 |
Phosphorylation of highly purified growth hormone receptors by a growth hormone receptor-associated tyrosine kinase.
Topics: Adenosine Triphosphate; Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Immunosorbent Techniques; Mice; Molecular Weight; Peptide Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Somatotropin; Tyrosine | 1989 |
Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes.
Topics: Animals; Cell Differentiation; Chickens; Cytoskeletal Proteins; Cytoskeleton; Intestinal Mucosa; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4-Positive T-Lymphocytes; CD8 Antigens; Cell Differentiation; Cross-Linking Reagents; Enzyme Activation; Mice; Mice, Inbred C57BL; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Thymus Gland; Tyrosine | 1989 |
Role of protein tyrosine phosphorylation in the NGF response.
Topics: Actin Cytoskeleton; Animals; Carbazoles; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Indole Alkaloids; Insulin; Microscopy, Fluorescence; Microtubules; Nerve Growth Factors; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1989 |
Tyrosine phosphorylated proteins accumulate in junctional regions of the developing chick neural retina.
Topics: Animals; Antibody Formation; Chick Embryo; Immunoblotting; Immunoenzyme Techniques; Nerve Tissue Proteins; Phosphotyrosine; Retina; Specimen Handling; Tyrosine | 1989 |
Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.
Topics: Amino Acid Sequence; Calcium; Calcium-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Humans; Ionomycin; Molecular Sequence Data; Monocytes; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1989 |
Insulin stimulates the tyrosine phosphorylation of a 165 kDa protein that is associated with microsomal membranes of rat adipocytes.
Topics: Adipose Tissue; Animals; Antibodies; Cells, Cultured; Insulin; Intracellular Membranes; Male; Membrane Proteins; Microsomes; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Subcellular Fractions; Tyrosine | 1989 |
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.
Topics: Actins; Binding, Competitive; Cell Line; Cell Membrane; Humans; Macromolecular Substances; Microscopy, Fluorescence; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein Conformation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1989 |
Insulin-stimulated protein tyrosine phosphorylation in intact cells evaluated by giant two-dimensional gel electrophoresis.
Topics: Animals; Cell Line; Cells, Cultured; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Insulin; Kinetics; Mice; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Subcellular Fractions; Tyrosine | 1989 |
Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Molecular Weight; Mutation; Myristic Acid; Myristic Acids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1989 |
Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; Gene Library; Hydra; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Restriction Mapping; RNA; Sequence Homology, Nucleic Acid; Tyrosine | 1989 |
Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes.
Topics: Animals; Antigens, Ly; CD4 Antigens; Cyanogen Bromide; Mice; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Signal Transduction; T-Lymphocytes; Tyrosine | 1989 |
Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.
Topics: Animals; Cell Count; Cell Division; Cell Line; Mutation; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Conformation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Transfection; Tyrosine | 1989 |
[Monoclonal antibodies to an artificial immunogen, specifically demonstrating phosphotyrosine-containing proteins].
Topics: Animals; Antibodies, Monoclonal; Cell Line, Transformed; Electrophoresis, Polyacrylamide Gel; Haptens; Immunoenzyme Techniques; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Rabbits; Rats; Tyrosine | 1989 |
Phosphotyrosine antibodies specifically label ameboid microglia in vitro and ramified microglia in vivo.
Topics: Animals; Brain; Immunohistochemistry; Neuroglia; Phosphotyrosine; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
PDGF induction of tyrosine phosphorylation of GTPase activating protein.
Topics: Cell Line; Cytosol; Fibroblast Growth Factors; Fibroblasts; GTPase-Activating Proteins; Humans; Immunoblotting; Immunosorbent Techniques; Insulin; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1989 |
Tyrosine-specific phosphorylation of calmodulin by the insulin receptor kinase purified from human placenta.
Topics: Calmodulin; Dose-Response Relationship, Drug; Humans; Insulin; Macromolecular Substances; Magnesium; Manganese; Phosphorylation; Phosphotyrosine; Placenta; Polylysine; Protamines; Protein Binding; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1989 |
Antibodies and radioimmunoassays for phosphoserine, phosphothreonine and phosphotyrosine. Serologic specificities and levels of the phosphoamino acids in cytoplasmic fractions of rat tissues.
Topics: Animals; Antibodies; Antibody Specificity; Chromatography, Ion Exchange; Cytoplasm; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred F344; Serine; Serum Albumin, Bovine; Threonine; Tyrosine | 1989 |
Presence of phospho-tyrosine in alkaline hydrolysate of pig skeletal muscle myosin.
Topics: Animals; Chromatography, Gel; Hydrogen-Ion Concentration; Hydrolysis; Muscles; Myosins; Phosphotyrosine; Swine; Tyrosine | 1989 |
A nonradioactive dot-blot assay for protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Antibodies; Breast Neoplasms; Cell Extracts; Humans; Immunoblotting; Immunohistochemistry; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Kinetics; Membranes, Artificial; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1989 |
The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; Humans; In Vitro Techniques; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Time Factors; Tyrosine | 1989 |
[Preparation of monoclonal antibodies to phosphotyrosine and their use for identification of phosphotyrosine-containing proteins].
Topics: Animals; Antibodies, Monoclonal; Chromatography, Affinity; Clone Cells; Electrophoresis, Polyacrylamide Gel; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1989 |
The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2.
Topics: Antigens, Differentiation, T-Lymphocyte; Blotting, Western; CD2 Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Immunologic; T-Lymphocytes; Time Factors; Tyrosine | 1989 |
Identification of proteins cross-reactive to phosphotyrosine antibodies and of a tyrosine kinase activity in boar spermatozoa.
Topics: Amino Acid Sequence; Animals; Antibodies; Blotting, Western; Calcimycin; Cross Reactions; Male; Molecular Sequence Data; Octoxynol; Oligopeptides; Phosphorylation; Phosphotyrosine; Polyethylene Glycols; Protein-Tyrosine Kinases; Solubility; Spermatozoa; Swine; Tyrosine; Vanadates | 1989 |
Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Line, Transformed; Deoxyglucose; Fibroblasts; Gene Expression Regulation; Mice; Monosaccharide Transport Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tyrosine | 1989 |
Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells.
Topics: Animals; Avian Sarcoma Viruses; Calcium-Binding Proteins; Cell Adhesion; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytoskeletal Proteins; Gelsolin; Gold; Immunohistochemistry; Microfilament Proteins; Microscopy, Electron; Oncogene Protein pp60(v-src); Phosphotyrosine; Rosette Formation; Tyrosine; Vinculin | 1989 |
Antiphosphotyrosine antibodies modulate insulin receptor kinase activity and insulin action.
Topics: Amino Acids; Animals; Antibodies; Antibody Specificity; Biological Transport; Cell-Free System; Glucose; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine | 1989 |
Characterization of phosphorylated amino acids by fast-atom bombardment mass spectrometry.
Topics: Phosphoserine; Phosphothreonine; Phosphotyrosine; Spectrometry, Mass, Fast Atom Bombardment; Tyrosine | 1989 |
Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Chickens; Cloning, Molecular; DNA, Complementary; Fusion Proteins, gag-onc; Gene Expression; Humans; Molecular Sequence Data; Nerve Tissue Proteins; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogenes; Rats; Receptor Protein-Tyrosine Kinases; Receptor, EphA8; Sequence Homology, Amino Acid; Tyrosine | 1988 |
Identification of cDNA clones that code for protein-tyrosine kinases by screening expression libraries with antibodies against phosphotyrosine.
Topics: Amino Acid Sequence; Antibodies; Base Sequence; Cloning, Molecular; DNA, Complementary; Fibroblasts; Gene Expression; Gene Library; Humans; Molecular Sequence Data; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1988 |
A selectable temperature-sensitive v-src Moloney retrovirus.
Topics: 3T3 Cells; Animals; Cell Line; Chickens; Genes, src; Mice; Moloney murine leukemia virus; Mutagenesis; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Restriction Mapping; Temperature; Transfection; Tyrosine | 1988 |
Epidermal growth factor stimulates tyrosine phosphorylation of pig epidermal fibrous keratin.
Topics: Animals; Autoradiography; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epidermis; Immunologic Techniques; Keratins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Swine; Tyrosine | 1985 |
Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeleton; Muscle Proteins; Phosphorylation; Phosphotyrosine; Tyrosine; Vinculin | 1985 |
Phosphotyrosyl-specific protein phosphatase activity of a bovine skeletal acid phosphatase isoenzyme. Comparison with the phosphotyrosyl protein phosphatase activity of skeletal alkaline phosphatase.
Topics: 4-Nitrophenylphosphatase; Acid Phosphatase; Alkaline Phosphatase; Animals; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Muscles; Phosphotyrosine; Tartrates; Tyrosine | 1985 |
Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody.
Topics: Animals; Antibodies; Binding Sites; Membranes; Mice; Mice, Inbred Strains; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Solubility; Tyrosine | 1985 |
Bone cell phosphotyrosine phosphatase: characterization and regulation by calcitropic hormones.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Calcitriol; Cell Division; Chick Embryo; Hydrogen-Ion Concentration; Kinetics; Male; Parathyroid Hormone; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Tyrosine | 1985 |
Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.
Topics: Animals; Antibodies; Cell Line; Dose-Response Relationship, Drug; Immunosorbent Techniques; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Tyrosine | 1985 |
Modifications in the phosphorylation of cell proteins related to the expression of src gene in chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Gene Expression Regulation; Molecular Weight; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine; Viral Proteins | 1984 |
Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins.
Topics: Abelson murine leukemia virus; Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae; Tyrosine | 1981 |
Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA.
Topics: Base Sequence; Binding Sites; DNA Polymerase I; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Viral; Escherichia coli; Micrococcus; Phosphotyrosine; Plasmids; Protein Binding; Tyrosine | 1980 |
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Chromatography, Thin Layer; Electrophoresis, Paper; Enzyme Activation; Epidermal Growth Factor; Humans; Membrane Proteins; Peptides; Phosphotyrosine; Protein Kinases; Tyrosine | 1980 |
Transformation by Rous sarcoma virus: a cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine; Viral Proteins | 1980 |
Distribution of phosphoserine, phosphothreonine and phosphotyrosine in proteins of vesicular stomatitis virus.
Topics: Animals; Cells, Cultured; Cricetinae; Kidney; Mesocricetus; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Tyrosine; Vesicular stomatitis Indiana virus; Viral Proteins | 1981 |
Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase.
Topics: Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Division; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeleton; Fibronectins; Fluorescent Antibody Technique; Microscopy, Electron, Scanning; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1981 |
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.
Topics: Carcinoma, Squamous Cell; Cations, Divalent; Cell Line; Cell Membrane; Humans; Kinetics; Membrane Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Tyrosine; Zinc | 1981 |
Differences in mechanisms of transformation by independent feline sarcoma virus isolates.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Mink; Phosphotyrosine; Protein Kinases; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1981 |
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase.
Topics: Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma Viruses, Feline; Serine; Tyrosine; Viral Proteins | 1981 |
Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Cytoplasm; Fibronectins; Interferons; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Rats; Temperature; Tyrosine | 1981 |
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1981 |
Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases.
Topics: Alkaline Phosphatase; Animals; Cattle; Escherichia coli; Histones; Intestines; Kinetics; Liver; Membrane Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine | 1981 |
A mouse homolog to the avian sarcoma virus src protein is a member of a protein kinase cascade.
Topics: Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Transformation, Viral; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Rats; Tyrosine; Viral Proteins | 1981 |
Transformation-defective mutants of Snyder-Theilen feline sarcoma virus lack tyrosine-specific protein kinase activity.
Topics: Animals; Cell Line; Cell Transformation, Viral; Genes, Viral; Mink; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1981 |
Purified low-molecular-weight protein kinase from murine sarcoma virus particles catalyzes tyrosine phosphorylation endogenously but phosphorylates cellular proteins at serine.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Transformation, Viral; Magnesium; Mice; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Sarcoma Viruses, Murine; Serine; Tyrosine | 1981 |
Tyrosine phosphorylation and oncogenes.
Topics: Animals; Cell Transformation, Neoplastic; Humans; Mice; Oncogenic Viruses; Phosphotyrosine; Protein Kinases; Rats; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1981 |
Reevaluation of cancer data eagerly awaited.
Topics: Biomedical Research; Cell Transformation, Viral; Glycolysis; Neoplasms, Experimental; Phosphotyrosine; Protein Kinases; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1981 |
Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine.
Topics: Animals; Chlorides; Edetic Acid; Fluorides; Hot Temperature; Liver; Manganese; Manganese Compounds; Muscles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphotyrosine; Potassium Chloride; Rats; Tyrosine; Zinc | 1981 |
Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Viral; Cell-Free System; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polyomavirus; Protein Kinases; Tyrosine | 1981 |
Human cells contain two forms of pp60c-src.
Topics: Carcinoma, Squamous Cell; Fibroblasts; Humans; Molecular Weight; Neoplasm Proteins; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphoproteins; Phosphotyrosine; Tyrosine; Viral Proteins | 1981 |
Cleavage of four avian sarcoma virus polyproteins with virion protease p15 removes gag sequences and yields large fragments that function as tyrosine phosphoacceptors in vitro.
Topics: Alpharetrovirus; Cell Transformation, Viral; Gene Products, gag; Peptide Fragments; Peptide Hydrolases; Phosphoproteins; Phosphotyrosine; Protein Kinases; Structure-Activity Relationship; Tyrosine; Viral Proteins | 1981 |
Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten.
Topics: Antibody Specificity; Cell Transformation, Viral; Chromatography, Affinity; Haptens; Phosphotyrosine; Proteins; Tyrosine | 1981 |
Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Genes; Molecular Weight; Peptide Biosynthesis; Phorbols; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1981 |
Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; DNA, Recombinant; Escherichia coli; Genes, Viral; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine | 1981 |
Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.
Topics: Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Receptors, Cell Surface; Tyrosine | 1981 |
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor.
Topics: Cells, Cultured; Fibroblasts; Growth Substances; Humans; Membrane Proteins; Molecular Weight; Neuroglia; Peptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Tyrosine | 1982 |
Bacterial expression of an enzymatically active protein encoded by RSV src gene.
Topics: Avian Sarcoma Viruses; Cloning, Molecular; DNA, Recombinant; Escherichia coli; Immunoglobulin G; Oncogene Protein pp60(v-src); Phosphotyrosine; Plasmids; Protein Kinases; Tyrosine; Viral Proteins | 1982 |
Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.
Topics: Animals; Cell Division; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Regeneration; Male; Microsomes, Liver; Phosphoproteins; Phosphotyrosine; Protein Kinases; Rats; Receptors, Cell Surface; Tyrosine | 1982 |
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1982 |
Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor.
Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; ErbB Receptors; Molecular Weight; Peptides; Phosphotyrosine; Rats; Receptors, Cell Surface; Transforming Growth Factors; Tyrosine | 1982 |
Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.
Topics: Alpharetrovirus; Animals; Cell Transformation, Viral; Chick Embryo; Genes, Viral; Phosphorylation; Phosphotyrosine; RNA, Viral; Tyrosine; Viral Proteins | 1982 |
Tumorigenicity of partial transformation mutants of Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Body Temperature; Cell Transformation, Viral; Chick Embryo; Chickens; Graft Rejection; Mice; Mice, Nude; Neoplasm Transplantation; Phosphotyrosine; Sarcoma, Avian; Species Specificity; Tyrosine; Virulence | 1982 |
Transformation by avian sarcoma viruses leads to phosphorylation of multiple cellular proteins on tyrosine residues.
Topics: Alpharetrovirus; Animals; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Proteins; Tyrosine; Viral Proteins | 1982 |
Phosphorylation and metabolism of the transforming protein of Rous sarcoma virus.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Oncogene Protein pp60(v-src); Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine; Viral Proteins | 1982 |
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system.
Topics: Animals; Cell Membrane; Cell-Free System; Insulin; Liver; Macromolecular Substances; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1982 |
Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.
Topics: Animals; Antigens, Viral; Antigens, Viral, Tumor; Cell Membrane; Cell Transformation, Viral; Cells, Cultured; Cytoplasm; DNA, Recombinant; Mice; Mutation; Phosphotyrosine; Polyomavirus; Protein Kinases; Structure-Activity Relationship; Tyrosine | 1982 |
Phosphotyrosine in proteins. Stability and quantification.
Topics: Antibodies, Neoplasm; Caseins; Drug Stability; Glutamate-Ammonia Ligase; Hydrogen-Ion Concentration; Hydrolysis; Immunoglobulin G; Peptides; Phosphotyrosine; Phosvitin; Proteins; Sarcoma; Transforming Growth Factors; Tyrosine | 1982 |
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.
Topics: Amino Acids; Animals; Insulin; Liver Neoplasms, Experimental; Macromolecular Substances; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Receptor, Insulin; Serine; Tyrosine | 1982 |
Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Compartmentation; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeleton; Detergents; Phosphoproteins; Phosphotyrosine; Protein Kinases; Solubility; Tyrosine | 1982 |
The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins.
Topics: Alpharetrovirus; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Chick Embryo; Molecular Weight; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1982 |
Sulphation of tyrosine residues-a widespread modification of proteins.
Topics: Animals; Cattle; Cells, Cultured; Chick Embryo; Molecular Weight; Phosphotyrosine; Proteins; Sulfates; Tyrosine | 1982 |
Separation of phosphohydroxyamino acids by high-performance liquid chromatography.
Topics: Animals; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cyclic AMP; Hydrolysis; Myelin Basic Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Serine; Threonine; Tyrosine | 1982 |
Purification of a specific reversible tyrosine-O-phosphate phosphatase.
Topics: Animals; Cations, Divalent; Drosophila melanogaster; Hydrogen-Ion Concentration; Phosphoric Monoester Hydrolases; Phosphotyrosine; Substrate Specificity; Tyrosine | 1982 |
Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.
Topics: Animals; Blood Platelets; Cations, Divalent; Cell Line; Cell Membrane; Enzyme Activation; Growth Substances; Mice; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Stimulation, Chemical; Tyrosine | 1982 |
Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Enzyme Activation; Magnesium; Manganese; Muscle Proteins; Phosphatidylinositols; Phospholipids; Phosphorylation; Phosphotyrosine; Protein Kinases; Substrate Specificity; Tyrosine; Vinculin | 1982 |
Two-dimensional separation of phosphoamino acids from nucleoside monophosphates.
Topics: Adenosine Monophosphate; Chromatography, Thin Layer; Cytidine Monophosphate; Electrophoresis; Escherichia coli; Guanosine Monophosphate; Nucleotides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Thymidine Monophosphate; Tyrosine; Uracil Nucleotides; Uridine Monophosphate | 1982 |
Tyrosine phosphorylation sites common to transforming proteins encoded by Gardner and Snyder-Theilen FeSV.
Topics: Animals; Cell Line; Cell Transformation, Viral; Molecular Weight; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Precursors; Protein Processing, Post-Translational; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1982 |
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes.
Topics: Amino Acid Sequence; Base Sequence; Biological Evolution; Cell Transformation, Viral; Gene Products, gag; Genes; Genes, Viral; Oncogenes; Phosphotyrosine; Protein Kinases; Retroviridae; Sarcoma Viruses, Feline; Substrate Specificity; Tyrosine; Viral Proteins | 1982 |
Monoclonal antibodies specific to transforming polyproteins encoded by independent isolates of feline sarcoma virus.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Ascitic Fluid; Hybridomas; Leukemia Virus, Feline; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred F344; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1982 |
Micrococcal nuclease cleavage of nucleotide linked to glutamine synthetase yields phosphotyrosine at the ligation site.
Topics: Adenosine Monophosphate; Calcium; Glutamate-Ammonia Ligase; Hydrogen-Ion Concentration; Micrococcal Nuclease; Phosphotyrosine; Substrate Specificity; Tyrosine | 1982 |
An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein.
Topics: Acid Phosphatase; Astrocytoma; Cell Line; Cell Membrane; Humans; Hydrogen-Ion Concentration; Neoplasms, Experimental; Phosphoprotein Phosphatases; Phosphoproteins; Phosphoserine; Phosphotyrosine; Substrate Specificity; Tyrosine | 1982 |
Abelson murine leukemia virus P120: identification and characterization of tyrosine phosphorylation sites.
Topics: Abelson murine leukemia virus; Animals; Chromatography, High Pressure Liquid; Leukemia Virus, Murine; Mice; Peptide Fragments; Phosphorylation; Phosphotyrosine; Trypsin; Tyrosine; Viral Proteins | 1982 |
Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity.
Topics: Antigens, Viral; Antigens, Viral, Tumor; Cell Compartmentation; Cell Membrane; Cytoskeleton; Molecular Weight; Phosphotyrosine; Polyomavirus; Protein Kinases; Tyrosine | 1982 |
In vivo tyrosine phosphorylations of the Abelson virus transforming protein are absent in its normal cellular homolog.
Topics: Abelson murine leukemia virus; Animals; Cell Transformation, Viral; Cross Reactions; Leukemia Virus, Murine; Mice; Oncogenes; Phosphorylation; Phosphotyrosine; Tyrosine | 1982 |
Feline sarcoma virus-specific transformation-related proteins and protein kinase activity in tumor cells.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Fibrosarcoma; Gene Products, gag; Melanoma; Mink; Peptides; Phosphotyrosine; Protein Kinases; Retroviridae; Retroviridae Proteins, Oncogenic; Sarcoma Viruses, Feline; Tumor Virus Infections; Tyrosine; Viral Proteins | 1983 |
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins.
Topics: Amino Acids; Animals; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Kinetics; Mice; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proteins; Tyrosine | 1982 |
Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Genetic Markers; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Species Specificity; Tyrosine; Viral Proteins | 1983 |
ts Transformation mutants of avian sarcoma virus PRCII: lack of strict correlation between transforming ability and properties of the P105-associated kinase.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Helper Viruses; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Temperature; Tyrosine; Viral Proteins | 1983 |
Dansylation and high-performance liquid chromatographic separation of phosphoserine, phosphothreonine and phosphotyrosine from 32P-labeled protein hydrolyzates.
Topics: Animals; Binding Sites; Chromatography, High Pressure Liquid; Dansyl Compounds; Hydrolysis; In Vitro Techniques; Isotope Labeling; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Rats; Serine; Threonine; Tyrosine | 1982 |
Reversal of Rous sarcoma-specific immunoglobulin phosphorylation on tyrosine (ADP as phosphate acceptor) catalyzed by the src gene kinase.
Topics: Adenosine Diphosphate; Animals; Avian Sarcoma Viruses; Immunoglobulin G; Kinetics; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Kinases; Rabbits; Thermodynamics; Tyrosine; Viral Proteins | 1983 |
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.
Topics: Female; Humans; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Kinases; Receptor, Insulin; Substrate Specificity; Tyrosine | 1983 |
Molecular events leading to fusiform morphological transformation by partial src deletion mutant of Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Fibronectins; Muscle Proteins; Mutation; Phosphoproteins; Phosphotyrosine; Tyrosine; Vinculin | 1983 |
Temperature-sensitive membrane association of pp60src in tsNY68-infected cells correlates with increased tyrosine phosphorylation of membrane-associated proteins.
Topics: Animals; Avian Sarcoma Viruses; Cell Membrane; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Membrane Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Temperature; Tyrosine; Viral Proteins | 1983 |
A rapid microdetermination of phosphoserine, phosphothreonine, and phosphotyrosine in proteins by automatic cation exchange on a conventional amino acid analyzer.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrolysis; Myocardium; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1983 |
Transformation parameters and pp60src localization in cells infected with partial transformation mutants of Rous sarcoma virus.
Topics: Animals; Cell Adhesion; Cell Compartmentation; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chickens; Contractile Proteins; Cytoskeleton; Fibronectins; Filamins; Microfilament Proteins; Muscle Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Tyrosine; Vinculin; Viral Proteins | 1983 |
Cultured cells transformed by Rous sarcoma virus: a genetically defined model and its phenotype.
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Models, Biological; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Tyrosine | 1983 |
Rous sarcoma virus-induced changes in the pattern of phosphorylation of non-histone nuclear proteins.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Chromosomal Proteins, Non-Histone; Fibroblasts; Hydrogen-Ion Concentration; Hydrolysis; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine | 1983 |
Detection and localization of a phosphotyrosine-containing onc gene product in feline tumor cells.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Melanoma; Mink; Neoplasm Proteins; Neoplasms, Experimental; Oncogenes; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma, Experimental; Tyrosine | 1983 |
Calmodulin-stimulated dephosphorylation of p-nitrophenyl phosphate and free phosphotyrosine by calcineurin.
Topics: Animals; Brain; Calcium; Calcium-Binding Proteins; Calmodulin; Calmodulin-Binding Proteins; Cations, Divalent; Cattle; Hydrogen-Ion Concentration; Kinetics; Magnesium; Nerve Tissue Proteins; Nitrophenols; Organophosphorus Compounds; Phosphotyrosine; Tyrosine | 1983 |
Localization and characterization of phosphorylation sites of the Fujinami avian sarcoma virus and PRCII virus transforming proteins.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Gene Products, gag; Phosphorylation; Phosphotyrosine; Tyrosine; Viral Proteins | 1982 |
The association of the transforming protein of Rous sarcoma virus with two cellular phosphoproteins.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chickens; Macromolecular Substances; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine; Viral Proteins | 1983 |
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.
Topics: Animals; Cell Membrane; Epidermal Growth Factor; Growth Substances; Manganese; Membrane Proteins; Mice; Molecular Weight; Peptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Tyrosine | 1983 |
Neural tissues express high levels of the cellular src gene product pp60c-src.
Topics: Age Factors; Animals; Brain; Chick Embryo; Nerve Tissue Proteins; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1983 |
Avian sarcoma viruses, protein kinases and cell transformation.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Epidermal Growth Factor; Escherichia coli; Gene Expression Regulation; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1983 |
Physical modification of purified Rous sarcoma virus pp60v-src protein after incubation with ATP/Mg2+.
Topics: Adenosine Triphosphate; Electrophoresis, Polyacrylamide Gel; Kinetics; Magnesium; Oncogene Protein pp60(v-src); Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1983 |
Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation.
Topics: Abelson murine leukemia virus; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Viral; Fibroblasts; Leukemia Virus, Murine; Lymphocytes; Mice; Molecular Weight; Peptides; Phosphotyrosine; Transforming Growth Factors; Tyrosine | 1983 |
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; Humans; Mice; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine | 1983 |
Polyamide thin-layer chromatography of phosphorylated tyrosine, threonine, and serine.
Topics: Chromatography, Thin Layer; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1983 |
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Immunoglobulin M; Phosphotyrosine; Pituitary Gland; Prolactin; Rats; Receptors, Cell Surface; Tyrosine | 1983 |
Immunological study of a cellular 35K phosphorylated polypeptide detected in Rous sarcoma virus transformed cells.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Coturnix; Cricetinae; Cytoskeleton; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinases; Rats; Tyrosine; Viral Proteins | 1983 |
Appearance of functional EGF receptor kinase during rodent embryogenesis.
Topics: Age Factors; Animals; ErbB Receptors; Liver; Mice; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Kinases; Rats; Tyrosine | 1983 |
Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase.
Topics: Abelson murine leukemia virus; Animals; Leukemia Virus, Murine; Mice; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Tyrosine | 1983 |
Purification of the receptor for epidermal growth factor from A-431 cells: its function as a tyrosyl kinase.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Receptors, Cell Surface; Tyrosine | 1983 |
Detection and quantification of phosphotyrosine in proteins.
Topics: Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Tyrosine | 1983 |
Base hydrolysis and amino acid analysis for phosphotyrosine in proteins.
Topics: Amino Acids; Hydrolysis; Methods; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Radioisotope Dilution Technique; Tyrosine | 1983 |
Measurement of chemical phosphate in proteins.
Topics: Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphotyrosine; Proteins; Radioisotope Dilution Technique; Serine; Tyrosine | 1983 |
Phosphorylation of tyrosine in cultured human placenta.
Topics: Female; Humans; Kinetics; Organ Culture Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Proteins; Tyrosine | 1983 |
Two different protein kinase activities are associated with the insulin receptor.
Topics: Animals; Caseins; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Histones; In Vitro Techniques; Isoenzymes; Liver; Male; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1983 |
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Mice; Mitogens; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinases; Proteins; Tyrosine | 1984 |
Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro.
Topics: Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Cells, Cultured; Mice; Peptide Fragments; Phosphorylation; Phosphotyrosine; Polyomavirus; Protein Kinases; Trypsin; Tyrosine; Viral Proteins | 1984 |
Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Chickens; ErbB Receptors; Female; Macromolecular Substances; Oviducts; Phosphorylation; Phosphotyrosine; Protein Kinases; Receptors, Cell Surface; Receptors, Progesterone; Tyrosine | 1984 |
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies.
Topics: Animals; Avian Sarcoma Viruses; Azo Compounds; Cell Transformation, Viral; Fluorescent Antibody Technique; Molecular Weight; Muscle Proteins; Oncogene Protein pp60(v-src); p-Azobenzenearsonate; Phosphoproteins; Phosphotyrosine; Tyrosine; Vinculin; Viral Proteins | 1984 |
Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation.
Topics: Animals; B-Lymphocytes; Burkitt Lymphoma; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Humans; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Spleen; T-Lymphocytes; Tyrosine | 1984 |
Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes.
Topics: Cells, Cultured; Humans; Monocytes; Phorbol Esters; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Phosphorylation of tyrosine in cultured human placenta.
Topics: Culture Techniques; Female; Gestational Age; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Kinases; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1984 |
Comparison of protein phosphorylations in variant A431 cells with different growth responses to epidermal growth factor.
Topics: Cell Line; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Receptors, Cell Surface; Tyrosine | 1984 |
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.
Topics: Female; Humans; Insulin; Molecular Weight; Peptide Fragments; Phosphotyrosine; Placenta; Pregnancy; Protein Binding; Protein Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1984 |
Functional studies on the Rous sarcoma virus transforming gene product.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Oncogene Protein pp60(v-src); Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine; Viral Proteins | 1984 |
Tyrosine protein kinase activity in normal rat tissues: brain.
Topics: Animals; Binding Sites; Brain; Cations, Divalent; Male; Nerve Tissue Proteins; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Structure-Activity Relationship; Tyrosine | 1984 |
Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Immunosorbent Techniques; Kinetics; Mice; Mice, Inbred BALB C; Molecular Weight; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Temperature; Tyrosine | 1984 |
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.
Topics: Animals; Cell Transformation, Viral; DNA, Neoplasm; Gene Expression Regulation; Humans; Leukemia, Experimental; Neoplasm Proteins; Oncogenes; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1984 |
The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Immunoglobulin Heavy Chains; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Kinases; Tyrosine; Vanadium; Viral Proteins | 1984 |
Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.
Topics: Animals; Annexins; Calcium-Binding Proteins; Cells, Cultured; Cyclic AMP; Glycoproteins; Lymphocyte Activation; Mice; Mitosis; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein Kinases; Proteins; Thymus Gland; Tyrosine | 1984 |
A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Oncogene Protein pp60(v-src); Phenylalanine; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1984 |
Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cross Reactions; Fibroblasts; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphotyrosine; Tyrosine | 1984 |
Use of an antiserum against phosphotyrosine for the identification of phosphorylated components in human fibroblasts stimulated by platelet-derived growth factor.
Topics: Antigen-Antibody Complex; Cell Line; Fibroblasts; Humans; Immune Sera; Infant, Newborn; Male; Peptide Fragments; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tyrosine | 1984 |
Tyrosyl kinases acquired from anchorage-independent cells by a membrane-enveloped virus.
Topics: Amino Acids; Animals; Cell Adhesion; Cell Line; Cell Transformation, Viral; Cricetinae; Kidney; Kinetics; Phosphorus Radioisotopes; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine; Vesicular stomatitis Indiana virus; Virion | 1984 |
The proteins of oncogenes.
Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins | 1984 |
Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.
Topics: Animals; Calmodulin; Cattle; Cell Nucleus; Cytosol; Enzyme Activation; Estradiol; Female; Kinetics; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Receptors, Estradiol; Receptors, Estrogen; Tyrosine; Uterus | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Biological and biochemical characterization of a new isolate of feline sarcoma virus: Theilen-Pedersen (TP1-FeSV).
Topics: Acylation; Animals; Cats; Cell Transformation, Viral; Cells, Cultured; Gene Products, gag; Oncogenes; Phosphotyrosine; Protein Kinases; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins; Virus Replication | 1984 |
Chemical properties, isolation, and analysis of O-phosphates in proteins.
Topics: Carbon Radioisotopes; Chemical Phenomena; Chemistry; Hydrolysis; Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tritium; Tyrosine | 1984 |
Visualization of phosphotyrosine containing molecules within the detergent insoluble cell matrix of v-src transformed fibroblasts.
Topics: Animals; Cell Transformation, Viral; Cells, Cultured; Detergents; Gold; Immunoenzyme Techniques; Mice; Mice, Inbred Strains; Oncogene Protein pp60(v-src); Phosphotyrosine; Tyrosine; Viral Proteins | 1984 |
Preparation and characterization of antibodies to O-phosphotyrosine and their use for identification of phosphotyrosine-containing proteins.
Topics: Animals; Antibodies; Antibody Specificity; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; ErbB Receptors; Female; Fluorescent Antibody Technique; Mice; Phosphorus Radioisotopes; Phosphotyrosine; Proteins; Rabbits; Receptors, Cell Surface; Tyrosine | 1984 |
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Hydrogen Bonding; Malonates; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oligopeptides; Phosphates; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Tyrosine | 1995 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyanogen Bromide; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Trypsin; Tyrosine | 1995 |
Stress-induced tyrosine phosphorylation of actin in Dictyostelium cells and localization of the phosphorylation site to tyrosine-53 adjacent to the DNase I binding loop.
Topics: Actins; Adenosine Triphosphate; Amino Acid Sequence; Animals; Azides; Binding Sites; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deoxyribonuclease I; Dictyostelium; Hot Temperature; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Sodium Azide; Stress, Physiological; Tyrosine | 1995 |
Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Epitopes; Genes, src; GTPase-Activating Proteins; Membrane Proteins; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Rats; Restriction Mapping; Subcellular Fractions; Tyrosine | 1993 |
Unidirectional cross-phosphorylation between the granulocyte colony-stimulating factor and interleukin 3 receptors.
Topics: Amino Acids; Animals; Cell Differentiation; Cell Division; Cell Line; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Macromolecular Substances; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Granulocyte Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Transfection; Tyrosine | 1993 |
T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T).
Topics: Animals; Binding Sites; CD3 Complex; In Vitro Techniques; Macromolecular Substances; Membrane Proteins; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptor Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1993 |
A neurofilament-associated kinase phosphorylates only a subset of sites in the tail of chicken midsize neurofilament protein.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell-Free System; Cells, Cultured; Chickens; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Ganglia, Spinal; Molecular Sequence Data; Neurofilament Proteins; Neurons; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Kinases; Recombinant Fusion Proteins; Spinal Cord; Tyrosine | 1993 |
A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Chick Embryo; DNA; ErbB Receptors; Humans; In Vitro Techniques; Molecular Sequence Data; Nucleic Acid Conformation; Oncogene Protein v-crk; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rabbits; Reticulocytes; Retroviridae Proteins, Oncogenic; RNA, Messenger; Tyrosine | 1993 |
The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Binding Sites; Cell Line; Cell Transformation, Viral; Chick Embryo; Humans; In Vitro Techniques; Leukocytes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; T-Lymphocytes; Tyrosine | 1993 |
Human bradykinin B2 receptors isolated by receptor-specific monoclonal antibodies are tyrosine phosphorylated.
Topics: Antibodies, Monoclonal; Bradykinin; Cells, Cultured; Chromatography, Affinity; Dinoprostone; Genistein; Humans; In Vitro Techniques; Isoflavones; Phosphotyrosine; Receptors, Bradykinin; Signal Transduction; Tyrosine | 1993 |
Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.
Topics: HeLa Cells; Humans; In Vitro Techniques; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins pp60(c-src); RNA Polymerase II; Substrate Specificity; Tyrosine | 1993 |
Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion.
Topics: Actin Cytoskeleton; Actins; Animals; Blotting, Western; Cell Adhesion; Cells, Cultured; Chick Embryo; Enzyme Activation; Fluorescent Antibody Technique; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Trypsin; Tyrosine | 1993 |
Association and phosphorylation-dependent dissociation of proteins in the insulin receptor complex.
Topics: Base Sequence; DNA Primers; GTPase-Activating Proteins; Humans; Hydrogen-Ion Concentration; Macromolecular Substances; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proteins; ras GTPase-Activating Proteins; Receptor, Insulin; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 1993 |
Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.
Topics: Base Sequence; Biological Transport; Cell Nucleus; Ciliary Neurotrophic Factor; DNA-Binding Proteins; Fibroblast Growth Factor 2; Gene Expression Regulation; HeLa Cells; Humans; Interferon-alpha; Interferon-gamma; Molecular Sequence Data; Molecular Weight; Nerve Tissue Proteins; Phosphoproteins; Phosphotyrosine; Regulatory Sequences, Nucleic Acid; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1993 |
Angiotensin II mediates intracellular signalling in vascular smooth muscle cells by activation of tyrosine-specific protein kinases and c-raf-1.
Topics: Angiotensin II; Animals; Aorta; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Kinetics; Molecular Weight; Muscle, Smooth, Vascular; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Signal Transduction; Time Factors; Tyrosine | 1993 |
Enzymatic and immunohistochemical evaluation of tyrosine phosphorylation in breast cancer specimens.
Topics: Breast; Breast Neoplasms; Cell Membrane; Cytosol; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Paraffin Embedding; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1993 |
Tyrosine phosphorylated proteins in chronic myelogenous leukemia.
Topics: Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; GTPase-Activating Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tumor Cells, Cultured; Tyrosine; Ultracentrifugation | 1993 |
Two distinct mechanisms for negative regulation of the Wee1 protein kinase.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Cyclins; Female; Homeostasis; Humans; Insecta; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Oligodeoxyribonucleotides; Ovum; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Restriction Mapping; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transfection; Tyrosine; Xenopus; Xenopus Proteins | 1993 |
Tyrosine kinase-dependent assembly of actin plaques linking Fc epsilon R1 cross-linking to increased cell substrate adhesion in RBL-2H3 tumor mast cells.
Topics: Actins; Animals; Antigens; Cell Adhesion; Mast Cells; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins.
Topics: Amino Acid Sequence; B-Lymphocytes; Base Sequence; Binding Sites; Cell Line; Epidermal Growth Factor; Glutathione Transferase; Humans; Interferon-alpha; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1993 |
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
Topics: 3T3 Cells; Animals; Cell Line; Cell Nucleus; Chickens; Enzyme Activation; Gene Expression; Interferon-alpha; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Kinetics; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; Transcription, Genetic; Transfection; Tyrosine | 1993 |
Inhibition of the activity of protein tyrosine phosphate 1C by its SH2 domains.
Topics: Amino Acid Sequence; Binding Sites; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Substrate Specificity; Sulfhydryl Compounds; Tyrosine | 1993 |
Purification and characterization of the cytoplasmic domain of human receptor-like protein tyrosine phosphatase RPTP mu.
Topics: Animals; Baculoviridae; Escherichia coli; Gene Deletion; Humans; Moths; Muramidase; Mutagenesis, Site-Directed; Myelin Basic Protein; Phosphotyrosine; Point Mutation; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1993 |
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Topics: 3T3 Cells; Animals; Benzoquinones; Catechols; Cell Differentiation; Cell Division; Cell Line; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Kinetics; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Platelet-Derived Growth Factor; Rifabutin; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
The tyrosine phosphorylation site of the acetylcholine receptor beta subunit is located in a highly immunogenic epitope implicated in channel function: antibody probes for beta subunit phosphorylation and function.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Epitopes; Humans; Ion Channels; Molecular Sequence Data; Peptides; Phosphotyrosine; Receptors, Nicotinic; Sequence Alignment; Sequence Homology, Amino Acid; Torpedo; Tyrosine | 1993 |
Acid phosphatase purified from Mycoplasma fermentans has protein tyrosine phosphatase-like activity.
Topics: Acid Phosphatase; Hydrogen-Ion Concentration; Mycoplasma; Mycoplasma fermentans; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1994 |
Insulin-like growth factor-I (IGF-I) dependent phosphorylation of the IGF-I receptor in MG-63 cells.
Topics: Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Insulin-Like Growth Factor I; Kinetics; Molecular Weight; Osteosarcoma; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Receptor, IGF Type 1; Tumor Cells, Cultured; Tyrosine | 1993 |
Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Brain; Cerebral Cortex; Choroid Plexus; Immunohistochemistry; Insulin Receptor Substrate Proteins; Male; Neurons; Paraventricular Hypothalamic Nucleus; Phosphoproteins; Phosphotyrosine; Pyramidal Tracts; Rats; Rats, Wistar; Tyrosine | 1993 |
Synergistic control mechanism for abnormal site phosphorylation of Alzheimer's diseased brain tau by kinase FA/GSK-3 alpha.
Topics: Alzheimer Disease; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Humans; Kinetics; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Substrate Specificity; tau Proteins; Tyrosine | 1993 |
Identification of anti-idiotypic antibodies to anti-phosphotyrosine antibodies in human sera.
Topics: Animals; Antibodies, Anti-Idiotypic; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Lupus Erythematosus, Systemic; Phosphotyrosine; Precipitin Tests; Rabbits; Tyrosine | 1993 |
Phosphotyrosine-containing proteins are concentrated in differentiating cells during chicken embryonic development.
Topics: Animals; Cell Differentiation; Cell Division; Chick Embryo; Immunohistochemistry; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine | 1993 |
MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands.
Topics: Antibodies; Breast Neoplasms; Cell Division; Female; Fibroblast Growth Factors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Fibroblast Growth Factor; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1994 |
Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Enzyme Activation; ErbB Receptors; Mice; Mitosis; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Colony-Stimulating Factor; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA Replication; Enzyme Activation; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Mice; Mitosis; Mutagenesis, Site-Directed; Phosphotyrosine; Proteins; Signal Transduction; Structure-Activity Relationship; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Topics: Animals; Calcium; Clone Cells; Immune Tolerance; Inositol Phosphates; Interferon-gamma; Interleukin-2; Interleukin-3; Mice; Mice, Inbred DBA; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Type C Phospholipases; Tyrosine | 1994 |
Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.
Topics: Base Sequence; Calcium; Genes, fos; Humans; Interleukin-2; Kinetics; Leukemia; Leukocyte Common Antigens; Lymphocyte Activation; Molecular Sequence Data; NF-kappa B; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Interleukin-2; RNA, Messenger; T-Lymphocytes; Transcription, Genetic; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vanadates | 1994 |
Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation and expression of murine hepatic cyclin dependent kinases.
Topics: Animals; Antibodies, Monoclonal; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Immunoblotting; Liver; Mice; Mice, Inbred C57BL; Phosphoproteins; Phosphotyrosine; Polychlorinated Dibenzodioxins; Protein Kinases; Protein Serine-Threonine Kinases; Reference Values; Tyrosine | 1993 |
Induction of tyrosine phosphorylation in human B lineage cells by crosslinking MB-1 molecule of B cell receptor-related heterodimer complex.
Topics: Amino Acid Sequence; Antibodies; Antibodies, Monoclonal; B-Lymphocytes; Cell Line; Cross-Linking Reagents; Humans; Macromolecular Substances; Molecular Sequence Data; Oligopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, B-Cell; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; Cytoplasm; DNA Primers; Helix-Loop-Helix Motifs; Humans; In Vitro Techniques; Mast Cells; Mice; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgE; Signal Transduction; Tyrosine | 1994 |
Pathways of signaling in nonspecific cytotoxic cells: effects of protein kinase and phosphatase inhibitors and evidence for membrane tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Catfishes; Cell Membrane; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Isoquinolines; Male; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sulfonamides; Tyrosine | 1994 |
Up-regulation of a thymic epithelial ligand after contact with thymocytes.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Line; Down-Regulation; Epithelial Cells; Genistein; In Vitro Techniques; Isoflavones; Ligands; Phosphotyrosine; Signal Transduction; T-Lymphocytes; Thymus Gland; Tyrosine; Up-Regulation | 1994 |
Insulin induces tyrosine phosphorylation of a 90-kDa protein during postischemic brain reperfusion.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Diabetes Mellitus, Experimental; Heart Arrest; Insulin; Ischemic Attack, Transient; Male; Myocardial Reperfusion; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Reperfusion; Resuscitation; Tyrosine | 1993 |
Phosphorylation of human erythrocyte band 3 by endogenous p72syk.
Topics: Anion Exchange Protein 1, Erythrocyte; Enzyme Precursors; Erythrocyte Membrane; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Peptide Mapping; Phosphotyrosine; Protein-Tyrosine Kinases; src-Family Kinases; Syk Kinase; Tyrosine | 1994 |
Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs).
Topics: Adult; Biomarkers, Tumor; ErbB Receptors; Glioblastoma; Humans; Immunohistochemistry; Middle Aged; Phosphotyrosine; Prognosis; Proto-Oncogene Proteins; Receptor, ErbB-2; Survival Rate; Transforming Growth Factor alpha; Tyrosine | 1993 |
Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line.
Topics: Animals; Becaplermin; Cell Line; Enzyme Activation; Epidermal Growth Factor; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Kinetics; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Receptors, Antigen, T-Cell; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Topics: Amino Acid Sequence; Antigens, CD; Binding Sites; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Activation; Humans; Kinetics; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Biological; Molecular Sequence Data; Peptide Mapping; Peptides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; src-Family Kinases; T-Lymphocytes; Transfection; Trypsin; Tyrosine | 1994 |
A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.
Topics: alpha-Macroglobulins; Animals; Antibodies; Base Sequence; Binding Sites; Blotting, Western; Cell Differentiation; Cell Line; Cell Nucleus; DNA; Genes, fos; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-6; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Promoter Regions, Genetic; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Tryptophan-tRNA Ligase; Tyrosine | 1994 |
Prokaryotic expression cloning of a novel human tyrosine kinase.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line; Cloning, Molecular; Embryo, Mammalian; Escherichia coli; Female; Fibroblasts; Gene Expression; Gene Library; Humans; Lung; Male; Molecular Sequence Data; Molecular Weight; Organ Specificity; Phosphotyrosine; Protein Biosynthesis; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Homology, Amino Acid; Transcription, Genetic; Tyrosine | 1994 |
Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
Topics: Adrenal Gland Neoplasms; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cell Membrane; Chromatography, Affinity; Guanosine Diphosphate; Imidazoles; Losartan; Oligopeptides; PC12 Cells; Pertussis Toxin; Pheochromocytoma; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles; Thionucleotides; Tyrosine; Virulence Factors, Bordetella | 1994 |
Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1.
Topics: Actins; Animals; Dictyostelium; DNA, Complementary; Fungal Proteins; Gene Expression; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, Protozoan; Genetic Vectors; GTP-Binding Proteins; Phosphoproteins; Phosphotyrosine; rap GTP-Binding Proteins; Transformation, Genetic; Tyrosine | 1993 |
GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Dogs; ErbB Receptors; Erythrocytes; G(M3) Ganglioside; Humans; Kinetics; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Tumor Cells, Cultured; Tyrosine | 1994 |
Okadaic acid blocks PDGF-induced proliferation of AKR-2B fibroblasts at the transition from G1- to S-phase.
Topics: Animals; Becaplermin; Cell Cycle; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Ethers, Cyclic; Fibroblasts; G1 Phase; Inositol Phosphates; Kinetics; Mice; Mice, Inbred AKR; Okadaic Acid; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-sis; Recombinant Proteins; S Phase; Signal Transduction; Thymidine; Tyrosine | 1994 |
Thyroid cell spreading and focal adhesion formation depend upon protein tyrosine phosphorylation and actin microfilaments.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Colchicine; Cytochalasin B; Fluorescent Antibody Technique; Genistein; Heparin; Isoflavones; Kinetics; Phosphotyrosine; Protein-Tyrosine Kinases; Swine; Thyroid Gland; Tyrosine; Vinculin | 1994 |
Tyrosine phosphorylation of protein kinase C-delta in response to its activation.
Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Genes, src; Interleukin-3; Isoenzymes; Mice; Molecular Sequence Data; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals.
Topics: Animals; Antigens, Surface; CD3 Complex; CD4 Antigens; CD4-Positive T-Lymphocytes; Enzyme Activation; In Vitro Techniques; Leukocyte Common Antigens; Ligands; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Glycoproteins; Mercuric Chloride; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Immunologic; Signal Transduction; Thy-1 Antigens; Tyrosine | 1994 |
Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B).
Topics: Amino Acid Sequence; Angiotensin II; Animals; Calcineurin; Calmodulin-Binding Proteins; Casein Kinases; Kinetics; Liver; Molecular Sequence Data; Phosphopeptides; Phosphoprotein Phosphatases; Phosphoserine; Phosphotyrosine; Protein Kinases; Rats; Substrate Specificity; Tyrosine | 1994 |
Specificity of protein interactions with highly related SRC homology (SH) domains of FGR and FYN protein-tyrosine kinases.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Line, Transformed; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1994 |
Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
Topics: Animals; CHO Cells; Cricetinae; Enzyme Activation; Humans; Insulin; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptor, Insulin; Signal Transduction; Structure-Activity Relationship; Time Factors; Transfection; Tyrosine | 1994 |
Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus.
Topics: Amino Acid Sequence; Cell Fractionation; Cell Nucleus; Epidermal Growth Factor; Epitopes; ErbB Receptors; Humans; Microscopy, Immunoelectron; Molecular Sequence Data; Nuclear Proteins; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1994 |
Synergistic activation of tyrosine phosphorylation by o-vanadate plus calcium ionophore A23187 or aromatic 1,2-diols.
Topics: Acetylcysteine; Angiotensin II; Animals; Calcimycin; Cell Line; Cell Line, Transformed; Drug Synergism; Egtazic Acid; Enzyme Activation; Flavonoids; Flavonols; Indomethacin; Liver; Masoprocol; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quercetin; Rats; Tyrosine; Vanadates | 1994 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Vanadate augments insulin-stimulated insulin receptor kinase activity and prolongs insulin action in rat adipocytes. Evidence for transduction of amplitude of signaling into duration of response.
Topics: Adipocytes; Animals; Dose-Response Relationship, Drug; Half-Life; Insulin; Kinetics; Lipids; Male; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Tyrosine; Vanadates | 1994 |
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 1994 |
Abundant but inactive-state gp140proto-trk is expressed in neuroblastomas of patients with good prognosis.
Topics: Age Factors; Child; Child, Preschool; Glioma; Humans; Infant; Neoplasm Staging; Neuroblastoma; Phosphorylation; Phosphotyrosine; Prognosis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Tumor Cells, Cultured; Tyrosine | 1994 |
Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells.
Topics: Burkitt Lymphoma; Cell Cycle Proteins; Cell Line; Hematopoiesis; Humans; Interferon Type I; Interferon-beta; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Promyelocytic, Acute; Multiple Myeloma; Phosphorus Radioisotopes; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Topics: 3-O-Methylglucose; Animals; Cell Line; Fibroblasts; Glucose; Humans; Insulin; Isoenzymes; Kinetics; Mannitol; Methylglucosides; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Gene Expression; Growth Inhibitors; Humans; Interleukin-11; Interleukin-6; Kinetics; Leukemia Inhibitory Factor; Lymphokines; Mice; Oncostatin M; Peptides; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Transcription, Genetic; Tyrosine | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Brain; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Hexokinase; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Molecular Weight; Organ Specificity; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Rats; Spermatozoa; Testis; Tyrosine | 1994 |
Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.
Topics: Actins; Animals; Chromatography, Affinity; Cytochalasin D; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Macromolecular Substances; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Weight; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Tyrosine | 1994 |
Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.
Topics: 3T3 Cells; Animals; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Growth Hormone; Humans; Interferon-gamma; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Transcription Factors; Tyrosine | 1994 |
Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse erythroleukemia cells.
Topics: Acetamides; Animals; Blotting, Northern; Cell Differentiation; Cell Line; DNA Probes; Enzyme Induction; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phosphotyrosine; Poly A; Protein Tyrosine Phosphatases; RNA; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Blood Cells; Cell Line; Fusion Proteins, bcr-abl; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Immunoblotting; Infant; Interleukin-3; Kinetics; Leukemia, Megakaryoblastic, Acute; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Stem Cell Factor; Transfection; Tyrosine | 1994 |
Activation of receptor-associated tyrosine kinase JAK2 by prolactin.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Cell Line; Enzyme Activation; Immunoblotting; Janus Kinase 2; Membrane Proteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Prolactin; Sheep; T-Lymphocytes; Tyrosine | 1994 |
rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.
Topics: Adult; Chromatography, Affinity; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Neutrophils; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Recombinant Proteins; Transcription Factors; Tyrosine | 1994 |
Multiple sites of phosphorylation within the alpha heavy chain of Chlamydomonas outer arm dynein.
Topics: Animals; Centrifugation, Density Gradient; Chlamydomonas; Dyneins; Flagella; Pancreatic Elastase; Peptide Fragments; Phosphates; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Trypsin; Tyrosine | 1994 |
Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation.
Topics: Alpharetrovirus; Animals; Blotting, Western; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Centrifugation, Density Gradient; Glycoproteins; Hexosaminidases; Oncogene Proteins, Viral; Oxidation-Reduction; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein-Tyrosine Kinases; Rats; Tyrosine | 1994 |
Growth hormone (GH) induces tyrosine-phosphorylated proteins in mouse L cells that express recombinant GH receptors.
Topics: Animals; Cattle; Cloning, Molecular; Growth Hormone; L Cells; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Somatotropin; Signal Transduction; Swine; Tyrosine | 1994 |
Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation.
Topics: Animals; Blotting, Western; Cells, Cultured; Cross-Linking Reagents; DNA Mutational Analysis; Enzyme Activation; ErbB Receptors; Fibroblasts; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Conformation; Proto-Oncogene Proteins; Receptor, ErbB-2; Recombinant Proteins; Sequence Deletion; Transfection; Tyrosine | 1994 |
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
Topics: Amino Acid Sequence; Animals; CD8 Antigens; Cell Line; Cytoplasm; Haplorhini; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Molecular Sequence Data; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Tumor Cells, Cultured; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1994 |
Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein.
Topics: Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Gene Expression; Humans; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Lymphoma, Non-Hodgkin; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Immunologic; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
Specific CD45 isoforms differentially regulate T cell receptor signaling.
Topics: Animals; Antibodies; Calcium; CD4 Antigens; Isoenzymes; Lymphocyte Activation; Mice; Mice, Transgenic; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.
Topics: 3T3 Cells; Angiotensin II; Animals; Antibodies; Aorta; Becaplermin; Cell Division; Culture Media, Conditioned; DNA; Dose-Response Relationship, Drug; Genes, fos; Growth Substances; Kinetics; Mice; Mitogens; Muscle, Smooth, Vascular; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Suramin; Thymidine; Tyrosine | 1994 |
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.
Topics: Animals; Antigens, CD; Base Sequence; CD28 Antigens; Cell Line; Humans; Kinetics; Mast-Cell Sarcoma; Mice; Molecular Sequence Data; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Signal Transduction; T-Lymphocytes; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Depolarization and neurotransmitters increase neuronal protein tyrosine phosphorylation.
Topics: Animals; Calcium; Cells, Cultured; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Neurons; Neurotransmitter Agents; Phosphorylation; Phosphotyrosine; Potassium Chloride; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine | 1994 |
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
Topics: Amino Acid Sequence; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; In Vitro Techniques; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Structural and functional aspects of the multiplicity of Neu differentiation factors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA Primers; DNA, Complementary; ErbB Receptors; Gene Expression; Genes; Glycoproteins; Humans; Molecular Sequence Data; Molecular Weight; Neuregulin-1; Neuregulins; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transfection; Tyrosine | 1994 |
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin; Membrane Proteins; Molecular Weight; Nerve Growth Factors; Neurons; Oncogene Protein v-crk; Paxillin; PC12 Cells; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, Nerve Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1994 |
Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation.
Topics: Base Sequence; Cell Line; Deoxyribonucleoproteins; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation; Growth Hormone; Humans; In Vitro Techniques; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tyrosine | 1994 |
Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Catalysis; ErbB Receptors; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Substrate Specificity; Tyrosine; Yersinia | 1994 |
Different patterns of calcium signaling triggered through two components of the B lymphocyte antigen receptor.
Topics: B-Lymphocytes; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Humans; Interleukin-2; Lymphoma, B-Cell; Macromolecular Substances; Models, Biological; Phosphoproteins; Phosphotyrosine; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; Signal Transduction; Terpenes; Thapsigargin; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1994 |
Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain.
Topics: Animals; Bicuculline; Brain; Brain Ischemia; Dizocilpine Maleate; Enzyme Activation; Hippocampus; Immunoblotting; Mitogens; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Seizures; Somatosensory Cortex; Tyrosine | 1993 |
Activation of macrophage PtdIns-PLC by phorbol ester and vanadate: involvement of reactive oxygen species and tyrosine phosphorylation.
Topics: Animals; Enzyme Activation; Female; Macrophages, Peritoneal; Mice; Phorbol Esters; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Reactive Oxygen Species; Tyrosine; Vanadates | 1994 |
Ethanol impairs insulin receptor substrate-1 mediated signal transduction during rat liver regeneration.
Topics: Animals; Ethanol; Female; Insulin Receptor Substrate Proteins; Liver Regeneration; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Signal Transduction; Tyrosine | 1994 |
The myotonin-protein kinase phosphorylates tyrosine residues in normal human skeletal muscle.
Topics: Amino Acid Sequence; Cloning, Molecular; Humans; Immunologic Techniques; Molecular Sequence Data; Muscle Proteins; Myotonic Dystrophy; Myotonin-Protein Kinase; Peptides; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tyrosine | 1994 |
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Topics: Amino Acid Sequence; DNA-Binding Proteins; Interferons; Ligands; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Binding; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1994 |
Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases.
Topics: Bacterial Toxins; Enterotoxins; Enzyme Activation; HLA-D Antigens; Humans; Monocytes; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src-Family Kinases; Staphylococcus; Superantigens; Tyrosine | 1994 |
Interleukin-7 regulates c-myc expression in murine T cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization.
Topics: Animals; Calcium; Concanavalin A; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation; Genes, myc; Interleukin-7; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; T-Lymphocytes; Thymus Gland; Time Factors; Transcriptional Activation; Tyrosine | 1994 |
Rous sarcoma virus-transformed cells develop peculiar adhesive structures along the cell periphery.
Topics: Actins; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Membrane; Cell Transformation, Viral; Cytoplasm; Fluorescent Antibody Technique; Integrins; Microscopy, Electron, Scanning Transmission; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Rats; Receptors, Cytoadhesin; Receptors, Fibronectin; Receptors, Vitronectin; Time Factors; Tyrosine | 1993 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases.
Topics: 3T3 Cells; Alkanes; Alkynes; Amides; Animals; Cell Division; ErbB Receptors; Humans; Hydrogen Bonding; Indoles; Mice; Molecular Structure; Naphthalenes; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1994 |
Lipocortin 2 (annexin 2) is a major substrate for constitutive tyrosine kinase activity in chondrocytes.
Topics: Animals; Annexin A2; Cartilage, Articular; Cattle; Cells, Cultured; Chromatography, Affinity; Collagenases; Gene Expression; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Substrate Specificity; Tyrosine; Vanadates | 1994 |
Effects of herbimycin A and ST638 on Fc epsilon receptor-mediated histamine release and Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells.
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Calcium; Cell Line; Cinnamates; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fura-2; Histamine Release; Inositol 1,4,5-Trisphosphate; Kinetics; Lactams, Macrocyclic; Leukemia, Basophilic, Acute; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Receptors, IgG; Rifabutin; Sulfides; Tumor Cells, Cultured; Tyrosine | 1994 |
Thioallyl compounds: potent inhibitors of cell proliferation.
Topics: Animals; Antineoplastic Agents; Aorta, Thoracic; CDC2 Protein Kinase; Cell Division; Cells, Cultured; Cysteine; Endothelium, Vascular; Garlic; GTPase-Activating Proteins; Humans; Kinetics; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plants, Medicinal; Protein Tyrosine Phosphatases; Proteins; Rats; Tyrosine; Umbilical Veins | 1994 |
Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate-1 via different phosphotyrosine motifs.
Topics: Binding Sites; Cells, Cultured; Glutathione Transferase; Insulin Receptor Substrate Proteins; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, Insulin; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1994 |
MAP kinase may play a role in the early phase of glucose transport in insulin treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Biological Transport, Active; Calcium-Calmodulin-Dependent Protein Kinases; Fibroblasts; Glucose; Glucose Transporter Type 1; Insulin; Mice; Monosaccharide Transport Proteins; Phorbol Esters; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Growth hormone-induced protein tyrosine phosphorylation in 3T3-F442A cells.
Topics: 3T3 Cells; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cytosol; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Hormone; Interleukin-2; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Signal Transduction; Tyrosine | 1993 |
Tyrosine phosphorylation of proteins during "priming" of neutrophils.
Topics: Antibodies, Monoclonal; Blotting, Western; Dose-Response Relationship, Drug; Humans; Kinetics; Molecular Weight; Neutrophils; Phosphoproteins; Phosphotyrosine; Substance P; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.
Topics: Animals; Base Sequence; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; DNA-Binding Proteins; Growth Hormone; Humans; Hypophysectomy; Liver; Male; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reference Values; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1994 |
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; Culture Media; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Tyrosine | 1994 |
Preferential inhibition of platelet-derived growth factor-stimulated DNA synthesis and protein tyrosine phosphorylation by nordihydroguaiaretic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cell Line; Cell Nucleus; Cells, Cultured; Dinoprostone; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Masoprocol; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Skin; Thymidine; Tyrosine | 1994 |
Two alternatively spliced forms of the human insulin-like growth factor I receptor have distinct biological activities and internalization kinetics.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Division; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Gene Expression; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, IGF Type 1; RNA, Messenger; Transcription, Genetic; Transfection; Tyrosine | 1994 |
Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
Topics: Amino Acid Sequence; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Base Sequence; Binding Sites; Calcium; Cell Line; Consensus Sequence; Humans; Interleukin-2; Kinetics; Lectins, C-Type; Lymphocyte Activation; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Receptors, Thrombin; RNA, Messenger; T-Lymphocytes; Thrombin; Tumor Cells, Cultured; Tyrosine | 1994 |
A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Division; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Intermediate Filament Proteins; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; PC12 Cells; Peripherins; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Time Factors; Type C Phospholipases; Tyrosine | 1994 |
Cytosolic Ca2+ transients are not required for platelet-derived growth factor to induce cell cycle progression of vascular smooth muscle cells in primary culture. Actions of tyrosine kinase.
Topics: Angiotensin II; Animals; Caffeine; Calcium; Cell Cycle; Cells, Cultured; Cytosol; Genistein; Isoflavones; Male; Muscle, Smooth, Vascular; Nitriles; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Ryanodine; Second Messenger Systems; Signal Transduction; Tyrosine | 1994 |
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.
Topics: Adaptor Proteins, Signal Transducing; GRB2 Adaptor Protein; GTP-Binding Proteins; Humans; Lymphocyte Activation; Macromolecular Substances; Membrane Proteins; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Binding; Proteins; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Son of Sevenless Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.
Topics: Amino Acid Sequence; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Cyclosporine; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Interleukin-1; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Recombinant Proteins; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Basic fibroblast growth factor-induced low density lipoprotein receptor transcription and surface expression. Signal transduction pathways mediated by the bFGF receptor tyrosine kinase.
Topics: Animals; Cells, Cultured; Cholesterol; Fibroblast Growth Factor 2; Gene Expression Regulation; Muscle, Smooth, Vascular; Phosphoproteins; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, LDL; RNA, Messenger; Signal Transduction; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1994 |
Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1994 |
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine | 1994 |
Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia.
Topics: Animals; Brain; Cell Membrane; Corpus Striatum; Cytosol; Enzyme Activation; Hippocampus; Immunohistochemistry; Ischemic Attack, Transient; Male; Mitogen-Activated Protein Kinase 1; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Tissue Distribution; Tyrosine | 1994 |
The role of individual Fc gamma receptors in aggregated IgG-stimulated protein tyrosine phosphorylation in the human neutrophil.
Topics: Antibodies, Monoclonal; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Hot Temperature; Humans; Immunoblotting; Immunoglobulin G; In Vitro Techniques; Interferon-gamma; Neutrophils; Phosphotyrosine; Receptors, IgG; Tyrosine | 1994 |
Insulin receptor substrate-1 (IRS-1) expression in rat brain.
Topics: Animals; Brain; Hippocampus; Immunohistochemistry; In Situ Hybridization; Insulin Receptor Substrate Proteins; Male; Neurons; Olfactory Bulb; Phosphoproteins; Phosphotyrosine; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 1994 |
Efficient Fmoc/solid-phase peptide synthesis of O-phosphotyrosyl-containing peptides and their use as phosphatase substrates.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Fluorenes; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Substrate Specificity; Tyrosine | 1994 |
Rapid interferon-gamma-stimulated tyrosine phosphorylation of cytosolic and membranal proteins in HL-60 promyelocytic cells.
Topics: Cell Differentiation; Cytosol; Humans; Interferon-gamma; Leukemia, Promyelocytic, Acute; Membrane Proteins; Monocytes; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1994 |
Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Fusion Proteins, bcr-abl; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Topics: Amino Acid Sequence; Animals; Binding Sites; Drosophila melanogaster; Genes, src; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proteins; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Tyrosine | 1994 |
Protein-tyrosine kinases: potential targets for anticancer drug development.
Topics: Drug Design; Humans; Hydroquinones; Neoplasms; Phenols; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1994 |
A tyrosine phosphorylation requirement for cytotoxic T lymphocyte degranulation.
Topics: Animals; Arsenicals; Calcium; Clone Cells; Concanavalin A; Fatty Acids, Nonesterified; Genistein; Ionomycin; Isoflavones; Kinetics; Lymphocyte Activation; Mice; Molecular Weight; Oleic Acid; Oleic Acids; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts.
Topics: Adult; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibroblasts; Humans; Immunoblotting; Kinetics; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Skin; Thymidine; Tyrosine | 1994 |
Accessibility of the c-Src SH2-domain for binding is increased during mitosis.
Topics: 3T3 Cells; Animals; Binding Sites; Cells, Cultured; Chickens; Mice; Mitosis; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Tyrosine | 1994 |
Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line.
Topics: Calcium; CD3 Complex; Cholera Toxin; G(M1) Ganglioside; Humans; Interleukin-2; Lymphocyte Activation; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor.
Topics: Animals; Antigens; B-Lymphocytes; Cell Line; Enzyme Activation; Leukocyte Common Antigens; Mice; Ovalbumin; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, B-Cell; Tyrosine | 1994 |
Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.
Topics: 3T3 Cells; Animals; Base Sequence; Glucose; GTPase-Activating Proteins; Humans; Insulin-Like Growth Factor I; Mice; Molecular Sequence Data; Mutagenesis; Ornithine Decarboxylase; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polymerase Chain Reaction; Proteins; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1994 |
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.
Topics: Animals; Blotting, Western; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
The nuclear tyrosine kinase c-Abl negatively regulates cell growth.
Topics: 3T3 Cells; Animals; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Gene Expression; Genes, abl; Genes, Dominant; Growth Inhibitors; Mice; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Transfection; Tyrosine | 1994 |
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Topics: Amino Acid Sequence; Animals; Base Sequence; Ciliary Neurotrophic Factor; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Growth Inhibitors; Humans; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Oligodeoxyribonucleotides; Oncostatin M; Peptides; Phosphotyrosine; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; STAT3 Transcription Factor; Tissue Distribution; Trans-Activators; Transcription Factors; Tyrosine | 1994 |
Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
Topics: Adenosine Triphosphate; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Catechols; Cell Line; Endocytosis; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Transferrin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Cross-linking of Fc gamma receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel.
Topics: Animals; B-Lymphocytes; Calcium; Cell Line; Cell Membrane; Cross-Linking Reagents; Egtazic Acid; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Immunoglobulin Fab Fragments; Immunoglobulin G; Indoles; Interleukin-2; Isoenzymes; Kinetics; Mice; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, IgG; Signal Transduction; Spectrometry, Fluorescence; Substrate Specificity; Type C Phospholipases; Tyrosine | 1994 |
Characterization of a 60-kilodalton substrate of the insulin receptor kinase.
Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cross Reactions; Electrophoresis, Polyacrylamide Gel; GTPase-Activating Proteins; Humans; Insulin; Kinetics; Molecular Weight; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Receptor, Insulin; Substrate Specificity; Transfection; Tyrosine | 1994 |
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Ciliary Neurotrophic Factor; Cytokines; Growth Inhibitors; Growth Substances; Humans; Interleukin-6; Isoenzymes; Leukemia Inhibitory Factor; Lymphokines; Macromolecular Substances; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Oncostatin M; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Type C Phospholipases; Tyrosine | 1994 |
Tyrosine and serine phosphorylation of dystrophin and the 58-kDa protein in the postsynaptic membrane of Torpedo electric organ.
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Centrifugation, Density Gradient; Dystrophin; Electric Organ; Electrophoresis, Polyacrylamide Gel; Membrane Proteins; Molecular Weight; Phosphoserine; Phosphotyrosine; Synaptic Membranes; Torpedo; Tyrosine | 1994 |
A target for Src in mitosis.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Line, Transformed; DNA-Binding Proteins; Interphase; Mice; Mitosis; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins pp60(c-src); RNA-Binding Proteins; Sequence Homology, Amino Acid; Tyrosine | 1994 |
Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.
Topics: Animals; Cell Division; CHO Cells; Cricetinae; Humans; Janus Kinase 1; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Granulocyte Colony-Stimulating Factor; Signal Transduction; Time Factors; Transfection; Tyrosine | 1994 |
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.
Topics: Animals; beta-N-Acetylhexosaminidases; Cell Membrane Permeability; Edetic Acid; In Vitro Techniques; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptors, IgE; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.
Topics: Biological Transport; Cell Compartmentation; Cell Membrane; Cytoplasm; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Neutrophils; Phospholipases A; Phospholipases A2; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Up-Regulation | 1994 |
Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.
Topics: Antigen-Antibody Complex; CD28 Antigens; Detergents; Humans; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells.
Topics: Animals; Cell Differentiation; Cell Line; Humans; Mitosis; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Stem Cells; Transfection; Tyrosine | 1994 |
Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cerebellum; Immunoblotting; Laminin; Leukocyte L1 Antigen Complex; Mice; Mice, Inbred C57BL; Mutation; Neurites; Neurons; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1994 |
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Electrophoresis, Polyacrylamide Gel; Gene Expression; Insulin; Kinetics; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma-chain.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Receptors, IgG; Tumor Cells, Cultured; Tyrosine | 1994 |
Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; CHO Cells; Cricetinae; DNA Primers; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Kinetics; Lymphocytes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Polymerase Chain Reaction; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptor, Insulin; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Tyrosine | 1994 |
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Baculoviridae; Binding Sites; CD3 Complex; CD5 Antigens; Cell Line; Genetic Vectors; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Moths; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Substrate Specificity; T-Lymphocytes; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1.
Topics: Adipocytes; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Tyrosine | 1994 |
The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases.
Topics: Angiotensin II; Animals; Aorta; Cells, Cultured; Cloning, Molecular; Genes, src; Glutathione Transferase; Isoenzymes; Kinetics; Muscle, Smooth, Vascular; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Angiotensin; Recombinant Fusion Proteins; Substrate Specificity; Type C Phospholipases; Tyrosine | 1994 |
Tyrosine phosphorylation of Shc is induced by IL-3, IL-5 and GM-CSF.
Topics: Animals; Blotting, Western; Cell Division; Cell Line; Enzyme Induction; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Interleukin-5; Kinetics; Mice; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Homology, Amino Acid; Thymidine; Tyrosine | 1994 |
Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; DNA, Complementary; Enzyme Activation; Mast-Cell Sarcoma; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.
Topics: Amino Acid Sequence; Animals; Base Sequence; CDC2 Protein Kinase; cdc25 Phosphatases; Cell-Free System; Consensus Sequence; Cyclins; Egg Proteins; Enzyme Activation; Fungal Proteins; Humans; Interphase; Mitosis; Molecular Sequence Data; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Xenopus | 1993 |
Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.
Topics: Aluminum Compounds; Calcium; CD3 Complex; Cell Line; Cytokines; Fluorides; Glutathione; Humans; In Vitro Techniques; Oxidation-Reduction; Phosphoserine; Phosphothreonine; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Terpenes; Thapsigargin; Tyrosine | 1994 |
The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.
Topics: Amino Acid Sequence; Animals; Cytoskeleton; Glycoproteins; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Subcellular Fractions; Tyrosine | 1994 |
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
Topics: Animals; Base Sequence; Cell Adhesion Molecules; Cell Line; Chick Embryo; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; DNA Primers; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; src-Family Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line.
Topics: Animals; Benzoquinones; Catechols; Cell Division; Cell Line; Genistein; Interleukin-3; Interleukin-4; Ionomycin; Isoflavones; Kinetics; Lactams, Macrocyclic; Leukemia, Basophilic, Acute; Leukotrienes; Mast-Cell Sarcoma; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calorimetry; Cloning, Molecular; Conserved Sequence; ErbB Receptors; Escherichia coli; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Homology, Amino Acid; Tyrosine | 1994 |
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Topics: Adenocarcinoma; Amino Acid Sequence; Antibodies; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Casein Kinases; Caseins; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Kinetics; Lung; Lung Neoplasms; Molecular Sequence Data; Myelin Basic Protein; Peptides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Proteins; Substrate Specificity; Tyrosine | 1994 |
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Catalysis; Enzyme Activation; Humans; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1994 |
Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.
Topics: Amino Acid Sequence; Cell Line; Cell Membrane; Cytoplasm; Fluorescent Antibody Technique; Humans; Immunologic Capping; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Peptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; T-Lymphocytes; Tyrosine | 1994 |
Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation.
Topics: Agrin; Alkaloids; Animals; Chick Embryo; Cytoskeleton; Muscles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Nicotinic; Staurosporine; Tyrosine | 1994 |
Strong increase in the tyrosine phosphorylation of actin upon inhibition of oxidative phosphorylation: correlation with reversible rearrangements in the actin skeleton of Dictyostelium cells.
Topics: Actins; Adenosine Triphosphate; Animals; Arsenicals; Cytoskeleton; Dictyostelium; Dinitrophenols; Electrophoresis, Polyacrylamide Gel; Genistein; Growth Inhibitors; Isoflavones; Microscopy, Fluorescence; Oxidative Phosphorylation; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1994 |
Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.
Topics: Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Immunoblotting; Interferon gamma Receptor; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interferon; Recombinant Proteins; Tyrosine | 1994 |
Okadaic acid, a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in A431 cells.
Topics: Alkaloids; Amino Acid Sequence; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Kinetics; Molecular Sequence Data; Molecular Weight; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1994 |
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
Topics: Animals; Cell Differentiation; Fibroblast Growth Factor 1; Filaggrin Proteins; Humans; Hydrolysis; Neurons; PC12 Cells; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Point Mutation; Rats; Receptors, Fibroblast Growth Factor; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glycogen Synthase Kinases; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Muscles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rabbits; Recombinant Proteins; Tyrosine | 1994 |
Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.
Topics: Animals; Carrier Proteins; Cell Line; Chlorocebus aethiops; Cross-Linking Reagents; ErbB Receptors; Gene Expression; Glycoproteins; Humans; Iodine Radioisotopes; Kinetics; Neuregulin-1; Neuregulins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogenes; Radioligand Assay; Receptor, ErbB-2; Receptor, ErbB-3; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actins; Alprostadil; Apyrase; Blood Platelets; Calcium; Cell Adhesion Molecules; Cytoplasm; Egtazic Acid; Epinephrine; Fibrinogen; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Indoles; Indomethacin; Maleimides; Models, Biological; Phosphorylation; Phosphotyrosine; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Thromboxane A2; Tyrosine; Vasodilator Agents | 1994 |
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
Topics: Calcium; Cell Membrane; Enzyme Activation; Glucuronidase; Glycerophospholipids; GTP-Binding Proteins; Guanosine Triphosphate; Histamine; Histamine Agonists; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositols; Phosphotyrosine; Receptors, Histamine H1; Respiratory Burst; Superoxides; Tumor Cells, Cultured; Tyrosine; Virulence Factors, Bordetella | 1994 |
Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.
Topics: Amino Acid Sequence; Binding Sites; Carrier Proteins; Cell Line; Glutathione Transferase; Humans; Kinetics; Leukemia, T-Cell; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.
Topics: Animals; B-Lymphocytes; Base Sequence; Cell Line; Conserved Sequence; DNA Primers; Glutathione Transferase; Immunoblotting; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; Restriction Mapping; src-Family Kinases; Tyrosine | 1994 |
Intracellular pathways activated by erythropoietin.
Topics: Cell Line; Erythropoietin; Growth Substances; Hematopoietic Cell Growth Factors; Humans; Leukemia, Erythroblastic, Acute; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptors, Erythropoietin; Signal Transduction; Stem Cell Factor; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors.
Topics: Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; In Vitro Techniques; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tyrosine | 1994 |
Insulin-stimulated tyrosine phosphorylation of protein kinase C alpha: evidence for direct interaction of the insulin receptor and protein kinase C in cells.
Topics: Animals; CHO Cells; Cricetinae; Insulin; Macromolecular Substances; Phosphotyrosine; Protein Binding; Protein Kinase C; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Endocytosis; Mice; Mutagenesis, Site-Directed; Mutation; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rabbits; Rats; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Tyrosine | 1994 |
PDGF-independent activation of PDGF-beta receptors in NIH-3T3 cells transformed by c-met protooncogene.
Topics: 3T3 Cells; Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; In Vitro Techniques; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Type C Phospholipases; Tyrosine | 1994 |
Differences in tyrosine phosphorylation of oocyte key proteins during 5HT-induced meiosis reinitiation in two bivalve species.
Topics: Animals; Bivalvia; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Egg Proteins; Enzyme Activation; Maturation-Promoting Factor; Meiosis; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oocytes; Phosphoproteins; Phosphotyrosine; Protamine Kinase; Serotonin; Species Specificity; Tyrosine | 1994 |
Neurite outgrowth stimulated by the tyrosine kinase inhibitor herbimycin A requires activation of tyrosine kinases and protein kinase C.
Topics: Animals; Benzoquinones; Calcium; Cerebellum; Enzyme Activation; Lactams, Macrocyclic; Nerve Tissue Proteins; Neurites; Neurons; Phenols; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1994 |
Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets.
Topics: Blood Platelets; Calcium; Edetic Acid; Enzyme Activation; Humans; Indoles; Maleimides; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tyrosine | 1994 |
Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.
Topics: Animals; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Moths; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; Recombinant Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; Substrate Specificity; Transfection; Tyrosine | 1994 |
CD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Calcium; CD3 Complex; Cell Adhesion Molecules; Cell Line; Chelating Agents; Humans; Indoles; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1994 |
The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line.
Topics: Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme Activation; Glutathione Transferase; Interleukin-2; Lymphocyte Activation; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; T-Lymphocytes; Tyrosine | 1994 |
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Burkitt Lymphoma; CD40 Antigens; Cell Line; Cell Line, Transformed; Enzyme Precursors; Genistein; Herpesvirus 4, Human; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Palatine Tonsil; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Sulfonamides; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Baculoviridae; Binding Sites; Breast; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Moths; Oligopeptides; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-3; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
In human neutrophils the binding to immunocomplexes induces the tyrosine phosphorylation of Fc gamma RII but this phosphorylation is not an essential signal for Fc-mediated phagocytosis.
Topics: Antigen-Antibody Complex; Genistein; Humans; Hydroquinones; In Vitro Techniques; Isoflavones; Neutrophils; Phagocytosis; Phosphorylation; Phosphotyrosine; Receptors, IgG; Tyrosine | 1994 |
Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Chick Embryo; DNA Primers; Enzyme Activation; Epitopes; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, EphB2; Retina; Tyrosine | 1994 |
Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants.
Topics: Animals; Enzyme Activation; Janus Kinase 2; Macromolecular Substances; Mammary Glands, Animal; Mice; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Prolactin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
Topics: Amino Acid Sequence; CD3 Complex; Enzyme Precursors; Humans; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Syk Kinase; T-Lymphocytes; Tyrosine | 1994 |
Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Hydrolysis; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phenylalanine; Phosphoric Monoester Hydrolases; Phosphotyrosine; Tyrosine | 1994 |
Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Precursors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Leukemia, Basophilic, Acute; Molecular Sequence Data; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Rats; Receptors, IgE; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
CD31 (PECAM-1), CDw32 (Fc gamma RII), and anti-HLA class I monoclonal antibodies recognize phosphotyrosine-containing proteins on the surface of human neutrophils.
Topics: 4-Chloromercuribenzenesulfonate; Antibodies, Monoclonal; Antigens, Differentiation, Myelomonocytic; Binding Sites; Cell Adhesion Molecules; HLA Antigens; Humans; In Vitro Techniques; Membrane Proteins; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Precipitin Tests; Protein Kinases; Receptors, IgG; Tyrosine | 1994 |
Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved.
Topics: Calcium; Electrophoresis, Gel, Two-Dimensional; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Signal Transduction; Tyrosine; Uric Acid; Virulence Factors, Bordetella | 1994 |
CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.
Topics: Calcium; CD4 Antigens; CD4-Positive T-Lymphocytes; Egtazic Acid; Humans; In Vitro Techniques; Inositol Phosphates; Leukocyte Common Antigens; Phosphoproteins; Phosphotyrosine; Receptor Aggregation; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Activation of src family kinases in human pre-B cells by IL-7.
Topics: Amino Acid Sequence; B-Lymphocytes; Cell Differentiation; Enzyme Activation; Hematopoiesis; Humans; Interleukin-7; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Interleukin; Receptors, Interleukin-7; Signal Transduction; src-Family Kinases; Tyrosine | 1994 |
Protein tyrosine phosphorylation triggered by human Fc gamma RII.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; B-Lymphocytes; Blotting, Western; Cell Line; Humans; Molecular Sequence Data; Monocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, IgG; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Increase of phosphotyrosine levels in mouse urine and liver during liver regeneration after partial hepatectomy.
Topics: Animals; Hepatectomy; Kinetics; Liver; Liver Regeneration; Male; Mice; Mice, Inbred Strains; Phosphotyrosine; Protein Tyrosine Phosphatases; Reference Values; Time Factors; Tyrosine; Vanadates | 1994 |
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
Topics: Animals; Base Sequence; Down-Regulation; Endocytosis; Fibroblast Growth Factor 1; Heparin; L Cells; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphotyrosine; Receptors, Fibroblast Growth Factor; Structure-Activity Relationship; Tyrosine | 1994 |
Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells.
Topics: Amino Acid Sequence; Calcium; Cyclic AMP; Humans; In Vitro Techniques; Molecular Sequence Data; Osteoblasts; Peptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Receptors, Thrombin; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Cells, Cultured; Tyrosine | 1994 |
Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.
Topics: Animals; Antigens, CD; B-Lymphocytes; CD79 Antigens; Immunoglobulin D; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin M; Leukocyte Common Antigens; Lymphocyte Activation; Macromolecular Substances; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Noscapine; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Tetrahydroisoquinolines; Tyrosine | 1994 |
The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.
Topics: Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Glutathione Transferase; GRB2 Adaptor Protein; Homeostasis; Humans; Isoenzymes; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; Proto-Oncogene Mas; Receptor Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1994 |
Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cell Line, Transformed; Genes, src; Glutathione Transferase; GTPase-Activating Proteins; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1994 |
Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation.
Topics: 1-Phosphatidylinositol 4-Kinase; 3T3 Cells; Animals; Cell Line; DNA; Enzyme Activation; Fibroblasts; Insulin; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptor, Insulin; Thymidine; Tyrosine | 1994 |
Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Calcium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Genistein; GTP Phosphohydrolases; GTP-Binding Proteins; Isoflavones; Lysophospholipids; Mice; Models, Biological; Myosins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.
Topics: Animals; Antibodies, Monoclonal; Catechols; Cell Line; Cytoplasm; Erythrocytes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Mice; Nitriles; Phagocytosis; Phosphorylation; Phosphotyrosine; Receptors, Fc; Signal Transduction; Transfection; Tyrosine; Tyrphostins | 1994 |
Tyrosine phosphorylation of alpha tubulin in human T lymphocytes.
Topics: Amino Acid Sequence; Electrophoresis, Gel, Two-Dimensional; Humans; Microtubules; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Precipitin Tests; T-Lymphocytes; Tubulin; Tumor Cells, Cultured; Tyrosine | 1994 |
Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Baculoviridae; Binding Sites; Cloning, Molecular; Humans; Mice; Molecular Sequence Data; Moths; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Type C Phospholipases; Tyrosine | 1994 |
Tyrosine phosphorylation of glycoproteins in the adult and developing rat brain.
Topics: Animals; Brain; Concanavalin A; Glycoproteins; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Synapses; Tyrosine | 1994 |
Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Calcium; CD3 Complex; CD8 Antigens; Cell Line; Humans; Interleukin-2; Lymphocyte Activation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotides, Antisense; Phosphotyrosine; Polymerase Chain Reaction; Protein Binding; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Transfection; Tyrosine | 1994 |
Tyrosine phosphorylation of phospholipase C-gamma 2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils.
Topics: Genistein; Humans; Isoenzymes; Isoflavones; Neutrophils; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Receptor Aggregation; Receptors, Fc; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine | 1994 |
BiP is a substrate for src kinase in vitro.
Topics: Carrier Proteins; Chaperonins; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; In Vitro Techniques; Molecular Chaperones; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Tyrosine | 1994 |
Immunofluorescent quantification of tyrosine phosphorylation of cellular proteins in whole cells by flow cytometry.
Topics: Antibodies, Monoclonal; Blotting, Western; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Leukemia, T-Cell; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteins; Sensitivity and Specificity; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1994 |
Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia.
Topics: Animals; Female; Gerbillinae; Hippocampus; Immunoblotting; Immunohistochemistry; Ischemic Attack, Transient; Neurons; Organ Specificity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pyramidal Cells; Reference Values; Time Factors; Tyrosine | 1994 |
Frequent expression of 75 kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: an immunohistochemical study on paraffin-embedded tissues.
Topics: Humans; Immunohistochemistry; Membrane Glycoproteins; Neurilemmoma; Neurofibromatoses; Neuroma; Peripheral Nervous System Neoplasms; Phosphotyrosine; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Tyrosine | 1994 |
Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Extracellular Matrix Proteins; Humans; Integrin beta1; Integrins; Kidney; Kinetics; Metallothionein; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Promoter Regions, Genetic; Recombinant Fusion Proteins; Restriction Mapping; Transfection; Tyrosine | 1994 |
Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA Primers; Fibroblast Growth Factor 1; Isoenzymes; Mice; Molecular Sequence Data; Muscles; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-4; Kinetics; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; Proto-Oncogenes; Receptors, Interleukin-4; Receptors, Mitogen; Recombinant Proteins; Time Factors; Transfection; Tyrosine | 1994 |
Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; GRB2 Adaptor Protein; Humans; Leukocyte Common Antigens; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proteins; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; Signal Transduction; Tyrosine | 1994 |
Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Baculoviridae; Binding Sites, Antibody; Blood Platelets; Endothelium, Vascular; Fibrinogen; Immunoglobulin Fab Fragments; In Vitro Techniques; Integrins; Molecular Sequence Data; Moths; Oligopeptides; Phosphotyrosine; Platelet Activation; Platelet Membrane Glycoproteins; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1994 |
Triton X-100-resistant membrane complexes from cultured kidney epithelial cells contain the Src family protein tyrosine kinase p62yes.
Topics: Animals; Cell Compartmentation; Cell Membrane; Dogs; Glycosylphosphatidylinositols; Kidney; Octoxynol; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Solubility; src-Family Kinases; Subcellular Fractions; Tyrosine | 1994 |
Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
Topics: Animals; Cell Line; Humans; Interleukin-2; Interleukin-4; Interleukin-7; Isoelectric Point; Janus Kinase 2; Janus Kinase 3; Leukocytes; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Interleukin-2; Signal Transduction; Time Factors; Tyrosine | 1994 |
Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation.
Topics: Adenosine Triphosphatases; Alkaloids; Amino Acid Sequence; Amino Acids; Animals; Antigens, CD; Base Sequence; Bile Acids and Salts; Biological Transport; Carrier Proteins; Cell Adhesion Molecules; Cells, Cultured; Consensus Sequence; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Phosphorylation and identification of a major tyrosine phosphorylation site in protein tyrosine phosphatase 1C.
Topics: Amino Acid Sequence; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tyrosine | 1994 |
Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity.
Topics: Antibodies; Benzoquinones; Carrier Proteins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Movement; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Hyaluronan Receptors; Hyaluronic Acid; Isoflavones; Lactams, Macrocyclic; Microinjections; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor, Insulin; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Rifabutin; Signal Transduction; Tyrosine; Vinculin | 1994 |
Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Cell Compartmentation; Enzyme Activation; In Vitro Techniques; Mast Cells; Mice; Mitogens; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, IgE; Signal Transduction; src-Family Kinases; Tyrosine | 1994 |
Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.
Topics: Animals; Base Sequence; Cloning, Molecular; Dictyostelium; DNA Primers; DNA, Complementary; Fungal Proteins; Genes, Fungal; Molecular Sequence Data; Phosphotyrosine; Protein Tyrosine Phosphatases; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine | 1994 |
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; ErbB Receptors; GRB2 Adaptor Protein; Humans; In Vitro Techniques; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1994 |
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Macromolecular Substances; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Swine; Syk Kinase; Tyrosine | 1994 |
Csk suppression of Src involves movement of Csk to sites of Src activity.
Topics: Animals; Base Sequence; Cell Compartmentation; CSK Tyrosine-Protein Kinase; DNA Primers; In Vitro Techniques; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.
Topics: Animals; Cell Line; Cell Membrane; Cell Nucleus; DNA-Binding Proteins; GTPase-Activating Proteins; Macromolecular Substances; Mice; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; RNA-Binding Proteins; Signal Transduction; Type C Phospholipases; Tyrosine | 1994 |
Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases.
Topics: Animals; Casein Kinase II; Cell Line; Cricetinae; Enzyme Activation; Humans; Leukocyte Common Antigens; Lymphocyte Activation; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; T-Lymphocytes; Time Factors; Tyrosine | 1994 |
Tyrosine phosphorylation of JAK-TYK kinases in malignant plasma cell lines growth-stimulated by interleukins 6 and 11.
Topics: Animals; Cell Division; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Interleukin-11; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plasmacytoma; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Recombinant Proteins; TYK2 Kinase; Tyrosine | 1994 |
Distinct binding properties of eaeA-negative verocytotoxin-producing Escherichia coli of serotype O113:H21.
Topics: Actinin; Adhesins, Bacterial; Bacterial Adhesion; Bacterial Outer Membrane Proteins; Bacterial Toxins; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Humans; Phosphotyrosine; Shiga Toxin 1; Tyrosine; Virulence | 1994 |
Detection of phosphotyrosine in glutaraldehyde-crosslinked and alkali-treated phosphoproteins following their partial acid hydrolysis in gels.
Topics: Acrylic Resins; Alkalies; Animals; Cross-Linking Reagents; Gels; Glutaral; Humans; Hydrolysis; Male; Phosphoproteins; Phosphorus Radioisotopes; Phosphotyrosine; Prostate; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tyrosine | 1994 |
Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium; Cell Adhesion Molecules; Cell Line; Egtazic Acid; Endothelins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Homeostasis; Immunosorbent Techniques; Kinetics; Lysophospholipids; Molecular Sequence Data; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Binding, Competitive; Brain-Derived Neurotrophic Factor; Genes, fos; Immunosorbent Techniques; Molecular Sequence Data; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; PC12 Cells; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tyrosine | 1994 |
Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression.
Topics: Animals; Bone Marrow Cells; Dog Diseases; Dogs; Gene Expression; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Leukocytes, Mononuclear; Periodicity; Phosphotyrosine; Receptors, Granulocyte Colony-Stimulating Factor; RNA, Messenger; Tyrosine | 1994 |
Inhibition of cellular response to platelet-derived growth factor by low M(r) phosphotyrosine protein phosphatase overexpression.
Topics: 3T3 Cells; Animals; Cell Division; Mice; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Cytoplasm; Gene Expression; Membrane Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phosphotyrosine; Receptors, Antigen, T-Cell; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes; Thymus Gland; Tyrosine | 1994 |
Phosphorylation and activation of mitogen-activated protein kinase by kainic acid-induced seizure in rat hippocampus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Hippocampus; Immunoblotting; Immunosorbent Techniques; Kainic Acid; Kinetics; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Seizures; Tyrosine | 1994 |
Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor.
Topics: Arachidonic Acid; CD18 Antigens; Cell Differentiation; Cell Division; Cell Line; Dimethyl Sulfoxide; Gene Expression; Genes, fos; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Integrins; Kinetics; Leukemia, Promyelocytic, Acute; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; Superoxides; Time Factors; Tumor Cells, Cultured; Tyrosine | 1994 |
Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.
Topics: Amino Acid Sequence; Antibodies; CD18 Antigens; Cell Adhesion; Enzyme Activation; Epitopes; Humans; Integrins; Kinetics; Molecular Sequence Data; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.
Topics: Antigens, Surface; Apoptosis; Cell Line; Enzyme Activation; fas Receptor; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Cell Surface; Signal Transduction; Tyrosine | 1994 |
Effect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolism.
Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Caseins; Concanavalin A; Female; Hydrogen Peroxide; Interferon gamma Receptor; Interferon-gamma; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphotyrosine; Receptors, Interferon; Recombinant Proteins; Signal Transduction; Spleen; Tyrosine | 1994 |
Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.
Topics: Animals; Cells, Cultured; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Gene Expression Regulation, Enzymologic; Genistein; Interleukin-3; Isoflavones; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine | 1994 |
The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes.
Topics: 3T3 Cells; Animals; Antigens, Polyomavirus Transforming; Baculoviridae; Catalysis; Immunosorbent Techniques; Kinetics; Mice; Moths; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins pp60(c-src); Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Tyrosine | 1994 |
Junctional uvomorulin/E-cadherin and phosphotyrosine-modified protein content are correlated with paracellular permeability in Madin-Darby canine kidney (MDCK) epithelia.
Topics: Animals; Cadherins; Cell Line; Cell Membrane; Cell Membrane Permeability; Dogs; Electric Conductivity; Electrophysiology; Epithelium; Hydrogen Peroxide; Intercellular Junctions; Kidney; Membrane Potentials; Microscopy, Electron; Microscopy, Electron, Scanning; Phosphoproteins; Phosphotyrosine; Tyrosine; Vanadates | 1994 |
Presence of growth factors in palmar and plantar fibromatoses.
Topics: Adult; Epidermal Growth Factor; Female; Fibroma; Fibronectins; Foot Dermatoses; Growth Substances; Hand Dermatoses; Humans; Immunohistochemistry; Male; Middle Aged; Phosphotyrosine; Procollagen; Transforming Growth Factor beta; Tyrosine | 1994 |
p210 bcr-abl confers overexpression of inosine monophosphate dehydrogenase: an intrinsic pathway to drug resistance mediated by oncogene.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Cell Division; Cell Line, Transformed; DNA Replication; Drug Resistance; Fusion Proteins, bcr-abl; Gene Expression; IMP Dehydrogenase; Mice; Oncogenes; Phosphoproteins; Phosphotyrosine; Poly A; Ribavirin; RNA; RNA, Messenger; Thymidine; Tyrosine | 1994 |
Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cell Differentiation; Dexamethasone; DNA Primers; Enzyme Activation; Gene Expression; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Molecular Sequence Data; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Receptor, Insulin; RNA, Messenger; Time Factors; Tyrosine | 1994 |
CD14-dependent induction of protein tyrosine phosphorylation by lipopolysaccharide in murine B-lymphoma cells.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Immunoglobulin M; Lipid A; Lipopolysaccharide Receptors; Lipopolysaccharides; Lymphoma, B-Cell; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Immunologic; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Cell Adhesion; Cell Adhesion Molecules; Humans; In Vitro Techniques; Leukocyte Common Antigens; Leukocytes; Lymphocyte Function-Associated Antigen-1; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1994 |
Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated beta 1 integrin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Adhesion; Cell Compartmentation; Cell Membrane; Cell Transformation, Viral; Integrin beta1; Integrins; Mice; Molecular Sequence Data; Peptides; Phosphotyrosine; Tyrosine | 1994 |
Microglial response to transient focal cerebral ischemia: an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody.
Topics: Animals; Antibodies, Monoclonal; Cell Count; Cerebral Cortex; Immunohistochemistry; Ischemic Attack, Transient; Male; Microglia; Phosphotyrosine; Rats; Rats, Wistar; Tyrosine | 1994 |
Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amidohydrolases; Aminopeptidases; Animals; Base Sequence; DNA Primers; Fungal Proteins; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Proteins; Recombinant Fusion Proteins; Repressor Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; SOS1 Protein; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1994 |
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.
Topics: Amino Acid Sequence; Humans; In Vitro Techniques; Ligands; Molecular Sequence Data; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Tyrosine | 1994 |
Expression of protein tyrosine kinases in islet cells: possible role of the Flk-1 receptor for beta-cell maturation from duct cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Cell Line; Culture Media; DNA; Gene Expression; Immunohistochemistry; Insulin; Islets of Langerhans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Tyrosine | 1994 |
Potent activation of phosphatidylinositol 3'-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains.
Topics: Amino Acid Sequence; Dose-Response Relationship, Drug; Enzyme Activation; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Structure-Activity Relationship; Tyrosine | 1994 |
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity.
Topics: Antigens, CD; B-Lymphocytes; Blotting, Western; Catechols; Cell Line; Cells, Cultured; Child; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Interleukin-7; Kinetics; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Receptors, Interleukin; Receptors, Interleukin-7; Recombinant Proteins; T-Lymphocytes; Thymus Gland; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites.
Topics: Animals; Base Sequence; Binding Sites; Cells, Cultured; Consensus Sequence; DNA-Binding Proteins; Humans; In Vitro Techniques; Lactoglobulins; Mammary Glands, Animal; Mice; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Prolactin; Transcription Factors; Tyrosine | 1994 |
Vanadate stimulates differentiation and neurite outgrowth in rat pheochromocytoma PC12 cells and neurite extension in human neuroblastoma SH-SY5Y cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Differentiation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Immunoblotting; Kinetics; Molecular Weight; Nerve Growth Factors; Neurites; Neuroblastoma; Neurons; PC12 Cells; Pheochromocytoma; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Time Factors; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
Evidence that increases in lymphocyte tyrosine phosphorylation precede cardiac allograft rejection. Effects of cyclosporine and potential use in clinical management.
Topics: Animals; Biomarkers; Cyclosporine; Flow Cytometry; Graft Rejection; Heart Transplantation; Immunoenzyme Techniques; Immunophenotyping; Lymphocytes; Myocardium; Phosphorylation; Phosphotyrosine; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction; Swine; Transplantation, Homologous; Tyrosine | 1994 |
Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Base Sequence; ErbB Receptors; GRB2 Adaptor Protein; Humans; Membrane Proteins; Molecular Sequence Data; Mutation; Peptides; Phosphotyrosine; Proline; Protein Binding; Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Son of Sevenless Proteins; Spectrometry, Fluorescence; Tyrosine | 1994 |
Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.
Topics: Androstadienes; Animals; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Macromolecular Substances; Neutrophils; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphopeptides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1994 |
Intramolecular and extramolecular mechanisms repress the catalytic function of p56lck in resting T-lymphocytes.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Conserved Sequence; Glutathione Transferase; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; T-Lymphocytes; Tyrosine | 1994 |
Endotoxin-induced early gene expression in C3H/HeJ (Lpsd) macrophages.
Topics: Animals; Blotting, Northern; Cells, Cultured; Endotoxins; Gene Expression Regulation; Immunoblotting; Interferon-gamma; Lipid A; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C3H; Phosphotyrosine; Tyrosine | 1994 |
Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; DNA; Endothelium, Vascular; Fibroblast Growth Factor 2; Genistein; Isoflavones; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Tyrosine | 1994 |
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tyrosine | 1994 |
Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Cell Line; Cytoplasm; Humans; Molecular Sequence Data; Mutagenesis; Phagocytosis; Phenylalanine; Phosphorylation; Phosphotyrosine; Receptors, IgG; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor.
Topics: DNA; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Humans; Immunosorbent Techniques; Janus Kinase 1; Janus Kinase 2; Leukemia, Monocytic, Acute; Macromolecular Substances; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
Topics: Benzoquinones; Cell Differentiation; Dexamethasone; Enzyme Activation; Granulocytes; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Monocytes; Mutation; Oncogene Protein p21(ras); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; ras GTPase-Activating Proteins; Rifabutin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1994 |
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Topics: Amino Acid Sequence; Animals; Crystallography, X-Ray; ErbB Receptors; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Models, Molecular; Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptide Fragments; Peptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; SH2 Domain-Containing Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tyrosine | 1994 |
Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II.
Topics: Angiotensin II; Animals; Cell Adhesion Molecules; Embryonic and Fetal Development; Enzyme Induction; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Muscle, Smooth, Vascular; Phosphotyrosine; Protein-Tyrosine Kinases; Time Factors; Tyrosine | 1994 |
Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Glutathione Transferase; Humans; Immunoblotting; Interleukin-7; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Protein Binding; Receptors, Interleukin; Receptors, Interleukin-7; Recombinant Fusion Proteins; Tyrosine | 1994 |
Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.
Topics: Amino Acid Sequence; Cell Line; Enzyme Activation; Enzyme Precursors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell; Signal Transduction; Syk Kinase; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1994 |
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; In Vitro Techniques; Interleukin-3; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Peptides; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tyrosine | 1994 |
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.
Topics: Amino Acid Sequence; CD4 Antigens; Cell Line; Enzyme Activation; HIV Envelope Protein gp120; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1994 |
Subset of CD4+ T cell clones expressing IL-3 receptor alpha-chains uses IL-3 as a cofactor in autocrine growth.
Topics: Animals; CD3 Complex; CD4-Positive T-Lymphocytes; Cell Division; Cell Line; Drug Synergism; Interleukin-3; Interleukin-4; Mice; Mice, Inbred C57BL; Phosphotyrosine; Receptors, Interleukin-3; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Tyrosine | 1994 |
Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.
Topics: Cell Line; Humans; In Vitro Techniques; Interferon-gamma; Macromolecular Substances; Phosphotyrosine; Receptor Aggregation; Receptor Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Up-Regulation | 1994 |
Activated Ki-Ras complements erythropoietin signaling in CTLL-2 cells, inducing tyrosine phosphorylation of a 160-kDa protein.
Topics: Cell Division; Cell Line; Erythropoietin; Genes, ras; Genes, src; Humans; Janus Kinase 2; Molecular Weight; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Receptors, Erythropoietin; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Tyrosine | 1994 |
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Mast Cells; Mice; Phosphotyrosine; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgE; Signal Transduction; Tyrosine | 1994 |
G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophils.
Topics: Cell Division; Granulocyte Colony-Stimulating Factor; Humans; Immunosorbent Techniques; Janus Kinase 2; Kinetics; Leukemia, Myeloid, Acute; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine phosphorylation in rat spinal cord after sciatic nerve transection.
Topics: Animals; Antibodies, Monoclonal; Immunohistochemistry; Male; Microscopy, Electron; Nerve Regeneration; Neuroglia; Neurons; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Tyrosine | 1994 |
Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Tyrosine | 1994 |
Epidermal growth factor-induced mitogen signals in cultured intestinal epithelial cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Epithelium; Jejunum; Mitogens; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Rats; Tyrosine | 1994 |
The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.
Topics: Adaptation, Physiological; Calcium-Calmodulin-Dependent Protein Kinases; Catalase; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Fungal; Genes, Fungal; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Osmotic Pressure; Phosphotyrosine; Protein Kinases; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription, Genetic; Tyrosine | 1994 |
Tyr394 and Tyr505 are autophosphorylated in recombinant Lck protein-tyrosine kinase expressed in Escherichia coli.
Topics: Amino Acid Sequence; Animals; Escherichia coli; Glutathione Transferase; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Tyrosine | 1994 |
A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.
Topics: Amino Acid Sequence; Animals; Aorta; Binding Sites; Cells, Cultured; Endothelium, Vascular; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Phosphates; Phosphopeptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Swine; Transfection; Tyrosine | 1994 |
Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase.
Topics: Amino Acid Sequence; Enzyme Precursors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Syk Kinase; Tyrosine | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Autophosphorylation-activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2A.
Topics: Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Glycogen Synthase Kinase 3; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protamine Kinase; Protein Kinases; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Substrate Specificity; Tyrosine | 1994 |
Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Calcium; Collagen; Humans; Immunoblotting; Immunosorbent Techniques; Phosphorylation; Phosphotyrosine; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Fc; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine; Wheat Germ Agglutinins | 1994 |
Phorbol 12-myristate 13-acetic acid inhibits PTP1B activity in human mesangial cells. A possible mechanism of enhanced tyrosine phosphorylation.
Topics: Glomerular Mesangium; Humans; Immunosorbent Techniques; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Chlamydia trachomatis serovar L2 induces protein tyrosine phosphorylation during uptake by HeLa cells.
Topics: Actins; Chlamydia Infections; Chlamydia trachomatis; Cytochalasin D; ErbB Receptors; Fluorescent Antibody Technique; HeLa Cells; Humans; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1994 |
Salmonella typhimurium invasion of epithelial cells: role of induced host cell tyrosine protein phosphorylation.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Epithelium; Genistein; HeLa Cells; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Salmonella Infections; Salmonella typhimurium; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.
Topics: Animals; Cell Adhesion; Cell Movement; Cell Size; CHO Cells; Cricetinae; Fibronectins; Glycoproteins; Integrin alpha3beta1; Integrin alphaV; Integrin beta1; Integrins; Laminin; Phosphorylation; Phosphotyrosine; Proteins; Receptors, Fibronectin; Transfection; Tyrosine; Vitronectin | 1994 |
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Immunoglobulin G; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscles; Neutralization Tests; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.
Topics: Animals; Apoptosis; Benzoquinones; CD3 Complex; Clonal Deletion; Dexamethasone; Genistein; Isoflavones; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein.
Topics: Base Sequence; Cells, Cultured; Chromatography, Agarose; DNA-Binding Proteins; Gene Expression Regulation; Genes, fos; Humans; Lymphocyte Activation; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Mas; Regulatory Sequences, Nucleic Acid; T-Lymphocytes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Nerve growth factor-induced differentiation in neuroblastoma cells expressing TrkA but lacking p75NGFR.
Topics: Adult; Blotting, Northern; Cell Differentiation; Corpus Striatum; Gene Expression; Genes, Immediate-Early; Humans; Nerve Growth Factors; Neurites; Neuroblastoma; Neurons; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Proteins; RNA, Messenger; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine kinase activity in Pseudomonas aeruginosa.
Topics: Adenosine Triphosphate; Ethylmaleimide; Flagellin; Mercuric Chloride; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pseudomonas aeruginosa; Substrate Specificity; Tyrosine | 1994 |
Does the insulin-mimetic action of vanadate involve insulin receptor kinase?
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Kinetics; Liver; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Reference Values; Tyrosine; Vanadates; Weight Gain | 1993 |
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
Topics: CD28 Antigens; CD3 Complex; Cell Line; Enzyme Activation; Histocompatibility Antigens Class I; Humans; Kinetics; Leukemia, T-Cell; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Time Factors; Tumor Cells, Cultured; Tyrosine | 1994 |
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Conserved Sequence; Enzyme Activation; Immunoglobulin G; Kinetics; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Time Factors; Tyrosine | 1994 |
Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cell Membrane; Gene Expression; HeLa Cells; Humans; Interferon-alpha; Macromolecular Substances; Membrane Proteins; Mice; Phosphorylation; Phosphotyrosine; Receptor, Interferon alpha-beta; Receptors, Interferon; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.
Topics: Cell Line; Flow Cytometry; Glucose; Glycogen; Glycosylphosphatidylinositols; Humans; Insulin; Kinetics; Leukemia, Erythroblastic, Acute; Mutagenesis; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Recombinant Fusion Proteins; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.
Topics: Amino Acid Sequence; B-Lymphocytes; CD3 Complex; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kinetics; Lymphocyte Activation; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1994 |
Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.
Topics: Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia; Animals; B-Lymphocytes; Cell Line; Enzyme Activation; Hematopoietic Stem Cells; Humans; Immunoglobulin M; Kinetics; Mice; Mice, Mutant Strains; Models, Biological; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Tyrosine; X Chromosome | 1994 |
Increased expression of phosphotyrosine after axotomy in the dorsal motor nucleus of the vagus nerve and the hypoglossal nucleus.
Topics: Animals; Axons; Hypoglossal Nerve; Immunohistochemistry; Lectins; Median Eminence; Medulla Oblongata; Nerve Regeneration; Neuroglia; Phosphotyrosine; Plant Lectins; Rats; Rats, Wistar; Tyrosine; Vagus Nerve | 1994 |
Mitogenic signaling of thrombin in mesangial cells: role of tyrosine phosphorylation.
Topics: Benzoquinones; Calcium; Cells, Cultured; Cysteine; DNA; Gene Expression; Genistein; Glomerular Mesangium; Humans; Immunoblotting; Inositol Phosphates; Isoflavones; Lactams, Macrocyclic; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Sulfur Radioisotopes; Thrombin; Tyrosine | 1994 |
Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s).
Topics: Blood Platelets; Blood Viscosity; Cytochalasin D; Egtazic Acid; Electrophoresis, Agar Gel; Enzyme Activation; Humans; Immunoblotting; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Stress, Mechanical; Tyrosine; von Willebrand Factor | 1994 |
Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Line; Chromatography, Affinity; CSK Tyrosine-Protein Kinase; Down-Regulation; Kinetics; Molecular Sequence Data; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Spodoptera; src-Family Kinases; Tyrosine | 1994 |
Stimulatory effect of pervanadate on calcium signals and histamine secretion of RBL-2H3 cells.
Topics: Animals; Calcium; Catalase; Histamine Release; Hydrogen Peroxide; Inositol 1,4,5-Trisphosphate; Leukemia, Basophilic, Acute; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
UV radiation induces DNA fragmentation and cell death in B16 melanoma sensitized by bromodeoxyuridine: impaired c-jun induction and defective tyrosine phosphorylation signalling.
Topics: Animals; Bromodeoxyuridine; Cell Death; Cell Survival; DNA Damage; DNA, Neoplasm; Ethers, Cyclic; Genes, jun; Immunoblotting; Melanoma, Experimental; Mice; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-jun; Radiation-Sensitizing Agents; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Ultraviolet Rays; Vanadates | 1994 |
Activation of mitogen-activated protein kinase cascade through erythropoietin receptor.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Erythropoietin; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Phosphoproteins; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-2; Signal Transduction; Transfection; Transferrin; Tyrosine | 1994 |
Potent inhibition of insulin receptor dephosphorylation by a hexamer peptide containing the phosphotyrosyl mimetic F2Pmp.
Topics: Amino Acid Sequence; Animals; Cell Membrane; CHO Cells; Cricetinae; Humans; Indicators and Reagents; Kinetics; Molecular Sequence Data; Oligopeptides; Phenylalanine; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Lovastatin disrupts early events in insulin signaling: a potential mechanism of lovastatin's anti-mitogenic activity.
Topics: Animals; Cell Line; Fibroblasts; Humans; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Lovastatin; Macromolecular Substances; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Signal Transduction; Transfection; Tyrosine | 1994 |
Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes.
Topics: Animals; Chromatography, Affinity; Cytosol; Glutathione Peroxidase; Intracellular Membranes; Male; Mitochondria; Peptide Mapping; Phospholipid Hydroperoxide Glutathione Peroxidase; Phosphotyrosine; Rats; Rats, Wistar; Solubility; Substrate Specificity; Testis; Tyrosine | 1994 |
Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Alkaloids; Amino Acid Sequence; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Molecular Weight; Neutrophils; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Staurosporine; Tyrosine | 1994 |
Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chamomile; Culture Media; Cyclic AMP; Dose-Response Relationship, Drug; Flavonoids; Genes, ras; Genistein; Isoflavones; Kaempferols; Mice; Oils, Volatile; Phenotype; Phosphotyrosine; Plants, Medicinal; Protein-Tyrosine Kinases; Quercetin; Tyrosine | 1994 |
PGE2 induces c-fos expression by a cAMP-independent mechanism in glomerular mesangial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Genes, jun; Glomerular Mesangium; Male; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Regulatory Sequences, Nucleic Acid; RNA, Messenger; TATA Box; Transcription Factor AP-1; Tyrosine | 1994 |
Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes.
Topics: Aggrecans; Animals; Blotting, Northern; Blotting, Western; Carrier Proteins; Cartilage, Articular; Cell Division; Cells, Cultured; Chondroitin Sulfate Proteoglycans; DNA; Drug Synergism; Extracellular Matrix Proteins; Insulin-Like Growth Factor I; Kinetics; Lectins, C-Type; Male; Phosphotyrosine; Proteoglycans; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Transforming Growth Factor beta; Tyrosine | 1994 |
Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin.
Topics: 3T3 Cells; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Base Sequence; Bombesin; Botulinum Toxins; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Mice; Molecular Sequence Data; Molecular Weight; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; rho GTP-Binding Proteins; Signal Transduction; Tyrosine | 1994 |
Tyrosine kinase inhibitors inhibit glucose-stimulated insulin secretion.
Topics: Animals; Catechols; Genistein; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Isoflavones; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tyrosine; Tyrphostins | 1994 |
Pioglitazone promotes insulin-induced activation of phosphoinositide 3-kinase in 3T3-L1 adipocytes by inhibiting a negative control mechanism.
Topics: 1-Phosphatidylinositol 4-Kinase; 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cyclic AMP; Enzyme Activation; Hypoglycemic Agents; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor I; Isoproterenol; Kinetics; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Pioglitazone; Thiazoles; Thiazolidinediones; Tyrosine | 1994 |
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.
Topics: Amino Acid Sequence; Animals; Binding Sites; GTPase-Activating Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Rats; Receptor, Insulin; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tyrosine | 1994 |
Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.
Topics: Animals; Base Sequence; DNA Primers; Mice; Molecular Sequence Data; Myelin Proteins; Myelin-Associated Glycoprotein; Nerve Fibers, Myelinated; Oligodendroglia; Peptide Mapping; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Recombinant Proteins; Signal Transduction; Type C Phospholipases; Tyrosine | 1994 |
c phosphorylation and activation of the IGF-I receptor in src-transformed cells.
Topics: Animals; Cell Line; Cell Transformation, Viral; Genes, src; Humans; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Time Factors; Transfection; Tyrosine | 1994 |
Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Enzyme Induction; Fibroblast Growth Factors; GTP-Binding Proteins; Molecular Sequence Data; Peptides; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Receptors, Thrombin; src-Family Kinases; Thrombin; Tyrosine | 1994 |
Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells.
Topics: Cells, Cultured; DNA-Binding Proteins; Growth Hormone; Humans; In Vitro Techniques; Interferon gamma Receptor; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interferon; Receptors, Somatotropin; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1994 |
Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Junctions; Mice; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Terpenes; Thapsigargin; Tyrosine | 1994 |
Rescue and activation of a binding-deficient insulin receptor. Evidence for intermolecular transphosphorylation.
Topics: 3T3 Cells; Animals; Enzyme Activation; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, Insulin; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Interactions of Lyn with the antigen receptor during B cell activation.
Topics: Animals; B-Lymphocytes; Base Sequence; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Lymphocyte Activation; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Syk Kinase; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.
Topics: Adolescent; Adult; CD18 Antigens; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Extracellular Matrix Proteins; Female; Humans; In Vitro Techniques; Integrins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Complement; Signal Transduction; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Enhanced phosphoinositide metabolism in colorectal carcinoma cells derived from familial adenomatous polyposis patients.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Cell Line; Chromatography, Affinity; Colorectal Neoplasms; Diglycerides; Electrophoresis, Polyacrylamide Gel; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotyrosine; RNA, Messenger; Second Messenger Systems; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1994 |
Concentration of pp125 focal adhesion kinase (FAK) at the myotendinous junction.
Topics: Animals; Antibodies, Monoclonal; Cell Adhesion Molecules; Cells, Cultured; Embryo, Nonmammalian; Enzyme Induction; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Larva; Male; Microspheres; Muscle Development; Muscle Proteins; Muscles; Neuromuscular Junction; Phosphotyrosine; Polystyrenes; Protein-Tyrosine Kinases; Sarcolemma; Tendons; Tyrosine; Xenopus | 1994 |
Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Adhesion Molecules; Chick Embryo; Consensus Sequence; Cytoskeletal Proteins; DNA, Complementary; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes; Microscopy, Fluorescence; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Vinculin | 1994 |
IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antibodies, Monoclonal; B-Lymphocytes; Benzoquinones; Cell Line; Cricetinae; Enzyme Activation; Humans; Interleukin-5; Janus Kinase 1; Janus Kinase 2; Kinetics; Lactams, Macrocyclic; Lymphocyte Activation; Macromolecular Substances; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Receptors, Interleukin; Receptors, Interleukin-5; Rifabutin; Transfection; Tyrosine | 1994 |
Changes in the tyrosine phosphorylation of mitogen-activated protein kinase in the rat hippocampus during and following severe hypoglycemia.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Electroencephalography; Glutamic Acid; Hippocampus; Hypoglycemia; Immunoblotting; Insulin; Male; Molecular Weight; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Tyrosine | 1994 |
Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; DNA Primers; Ethanol; Glioblastoma; In Vitro Techniques; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Molecular Sequence Data; Neuroglia; Peptides; Phosphoproteins; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; DNA Damage; DNA, Neoplasm; In Vitro Techniques; Microtubules; Paclitaxel; Phosphoproteins; Phosphotyrosine; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tubulin; Tumor Cells, Cultured; Tyrosine | 1994 |
Evidence that ras and myc mediate the synergy between SCF or M-CSF and other haemopoietic growth factors.
Topics: Animals; Base Sequence; Cell Division; Cell Line; Gene Expression; Genes, myc; Genes, ras; Growth Substances; Hematopoietic Cell Growth Factors; Macrophage Colony-Stimulating Factor; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Proto-Oncogene Mas; Rats; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Stem Cell Factor; Structure-Activity Relationship; Tyrosine | 1994 |
Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Enzyme Activation; Epidermal Growth Factor; Growth Inhibitors; Humans; In Vitro Techniques; Interferons; Isoenzymes; Mice; Molecular Sequence Data; Oligonucleotide Probes; Phorbol Esters; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Signal Transduction; Tyrosine | 1994 |
CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.
Topics: Amino Acid Sequence; Base Sequence; Calcium; Cells, Cultured; DNA Primers; In Vitro Techniques; Leukocyte Common Antigens; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristates; Phosphotyrosine; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes; Tyrosine | 1994 |
Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
Topics: DNA-Binding Proteins; Humans; In Vitro Techniques; Interferon-alpha; Janus Kinase 1; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Receptor, Interferon alpha-beta; Receptors, Interferon; Recombinant Proteins; Signal Transduction; STAT2 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1994 |
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.
Topics: 3T3 Cells; Alternative Splicing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; beta Catenin; Cadherins; Catenins; Cattle; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Trans-Activators; Tyrosine | 1994 |
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.
Topics: Amino Acid Sequence; Animals; Cell Line; Hematopoiesis; Hematopoietic Cell Growth Factors; Mice; Molecular Sequence Data; Peptides; Phosphotyrosine; Proline-Rich Protein Domains; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Stem Cell Factor; Tyrosine | 1994 |
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Topics: Animals; Blood Glucose; Female; Growth; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine | 1994 |
Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.
Topics: Apoptosis; Arsenicals; Eosinophils; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoflavones; Neutrophils; Phosphoprotein Phosphatases; Phosphotyrosine; Signal Transduction; Tyrosine | 1994 |
Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.
Topics: CD3 Complex; Cell Line; Humans; In Vitro Techniques; Leukocyte Common Antigens; Phosphotyrosine; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Tyrosine | 1994 |
Modulatory effect of the transmembrane domain of the protein-tyrosine kinase encoded by oncogene ros: biological function and substrate interaction.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; In Vitro Techniques; Membrane Glycoproteins; Mitogens; Mutagenesis, Site-Directed; Oncogene Proteins, Viral; Peptide Mapping; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.
Topics: Animals; In Vitro Techniques; Kinetics; Mast Cells; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptor Protein-Tyrosine Kinases; Receptors, IgE; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1994 |
Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.
Topics: Animals; Cross-Linking Reagents; Enzyme Activation; In Vitro Techniques; Macromolecular Substances; Mast Cells; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptor Protein-Tyrosine Kinases; Receptors, IgE; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1994 |
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Topics: Benzoquinones; Cell Line; Gene Expression; Gene Rearrangement, T-Lymphocyte; Humans; In Vitro Techniques; Lactams, Macrocyclic; NF-kappa B; Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.
Topics: Animals; Avian Proteins; Cell Differentiation; Gene Expression; In Situ Hybridization; Nerve Tissue Proteins; Neuregulin-1; Oligodendroglia; Phosphoproteins; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Schwann Cells; Tyrosine | 1994 |
Tyrosine-phosphorylated calmodulin has reduced biological activity.
Topics: Amino Acid Sequence; Calcium; Calmodulin; Dose-Response Relationship, Drug; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Nucleotides, Cyclic; Peptide Fragments; Peptides; Phosphopeptides; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Sequence Analysis; Tyrosine; Wasp Venoms | 1994 |
Rapid stimulation of mitogen-activated protein kinase of rat liver by prolactin.
Topics: Animals; Antibodies, Monoclonal; Cytosol; Densitometry; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Immunoblotting; Injections, Intraperitoneal; Liver; Mitogen-Activated Protein Kinase 1; Molecular Weight; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Prolactin; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Substrate Specificity; Tyrosine | 1994 |
Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Epidermal Growth Factor; Estradiol; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; In Vitro Techniques; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
P56lck: a transducing protein that binds to SH2 containing proteins and to phosphotyrosine containing proteins.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Peptides; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Tyrosine | 1994 |
Determination of antigen-antibody affinity by immunocapillary electrophoresis.
Topics: Antibodies, Monoclonal; Antigen-Antibody Complex; Capillary Action; Electrophoresis; Hydrogen-Ion Concentration; Immunologic Techniques; Kinetics; Phosphoserine; Phosphotyrosine; Tyrosine | 1994 |
Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphorylation events.
Topics: Antibodies; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Collagen; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycoproteins; Humans; Integrins; Laminin; Macromolecular Substances; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Umbilical Veins; Vitronectin | 1994 |
Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1.
Topics: Adipocytes; Adipose Tissue; Animals; Blotting, Western; Cells, Cultured; Epididymis; Growth Hormone; Insulin; Insulin Receptor Substrate Proteins; Kidney; Kinetics; Male; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Triglycerides; Tyrosine | 1994 |
Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk.
Topics: Animals; Antibodies; Blood Platelets; Cell Line; CSK Tyrosine-Protein Kinase; Cysteine; Glutathione Transferase; Humans; Immunoblotting; Kinetics; Leukemia, Erythroblastic, Acute; Methionine; Molecular Weight; Neoplasm Proteins; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rabbits; Receptors, IgG; src-Family Kinases; Sulfur Radioisotopes; Tumor Cells, Cultured; Tyrosine | 1994 |
Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Kinetics; Molecular Sequence Data; Molecular Weight; Oncogene Protein pp60(v-src); Phosphopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Spodoptera; Transfection; Tyrosine | 1994 |
Tyrosine-containing sequence motifs of the human immunoglobulin G receptors FcRIIb1 and FcRIIb2 essential for endocytosis and regulation of calcium flux in B cells.
Topics: Animals; B-Lymphocytes; Base Sequence; Calcium; Cell Line; Cross-Linking Reagents; Endocytosis; Homeostasis; Humans; Immunoglobulin G; Kinetics; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Polymerase Chain Reaction; Receptors, IgG; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways.
Topics: Blotting, Western; Cell Line; Humans; Male; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoproteins; Phosphotyrosine; Prostatic Neoplasms; Protein-Tyrosine Kinases; Receptors, Transforming Growth Factor beta; Signal Transduction; src-Family Kinases; Transforming Growth Factor beta; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions.
Topics: 3T3 Cells; Actins; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Culture Media, Serum-Free; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Isoenzymes; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Stress, Mechanical; Tyrosine | 1994 |
Early lymphocyte activation events are inhibited by antiproliferative synthetic peptide 2438, a fragment of human interferon alpha-2, and immunosuppressant cyclosporine A.
Topics: Calcium; Concanavalin A; Cyclosporine; Cytosol; Humans; Interferon-alpha; Interferons; Lymphocyte Activation; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; T-Lymphocytes; Tyrosine | 1994 |
Platelet-derived growth factor stimulates phosphorylation of growth factor receptor-binding protein-2 in vascular smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; ErbB Receptors; GRB2 Adaptor Protein; In Vitro Techniques; Muscle, Smooth, Vascular; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; Rats; Signal Transduction; Tyrosine | 1994 |
Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.
Topics: Angiotensin II; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; DNA-Binding Proteins; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Myocardium; Nuclear Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Signal Transduction; STAT1 Transcription Factor; Tetrazoles; Trans-Activators; Transcription Factors; Transcription, Genetic; Tyrosine | 1994 |
Tyrosine phosphorylation of a M(r) 38,000 A/B-type hnRNP protein selectively modulates its RNA binding.
Topics: Amino Acid Sequence; Animals; Artemia; Blotting, Western; Creatine Kinase; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Heterogeneous-Nuclear Ribonucleoproteins; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Ribonucleoproteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tyrosine | 1994 |
Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.
Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; Cloning, Molecular; DNA Primers; Molecular Sequence Data; Phosphoserine; Phosphothreonine; Phosphotyrosine; Plant Proteins; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1994 |
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Calorimetry; ErbB Receptors; GRB2 Adaptor Protein; Humans; In Vitro Techniques; Kinetics; Ligands; Membrane Proteins; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Proteins; Signal Transduction; Son of Sevenless Proteins; Tyrosine | 1994 |
Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase.
Topics: Amino Acid Sequence; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; In Vitro Techniques; Interleukin-3; Janus Kinase 2; Molecular Sequence Data; Peptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Signal Transduction; Stem Cell Factor; Tyrosine | 1994 |
Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
Topics: Amino Acid Sequence; Cell Adhesion Molecules; Cell Division; Crystallography, X-Ray; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1994 |
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.
Topics: Benzoquinones; Carcinoma, Squamous Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Integrins; Lactams, Macrocyclic; Mouth Neoplasms; Neoplasm Invasiveness; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
Topics: Animals; DNA Mutational Analysis; Down-Regulation; Endopeptidases; Hematopoietic Cell Growth Factors; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Weight; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Stem Cell Factor; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Ubiquitins | 1994 |
Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.
Topics: Amino Acid Sequence; Cell Cycle Proteins; Cell Line; Erythropoietin; Gene Expression Regulation; Humans; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Proto-Oncogene Proteins c-vav; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1994 |
Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells.
Topics: Animals; Base Sequence; Binding Sites; Caseins; Cell Line; Cells, Cultured; Cytokines; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Epithelial Cells; Glucocorticoids; Insulin; Lactation; Macrophages; Mammary Glands, Animal; Mice; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Sequence Homology, Nucleic Acid; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
An alternative to SH2 domains for binding tyrosine-phosphorylated proteins.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line; Humans; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1994 |
Structural determinants of substrate selection by the human insulin-receptor protein-tyrosine kinase.
Topics: Amino Acid Sequence; Binding Sites; Electrochemistry; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Receptor, Insulin; Substrate Specificity; Tyrosine | 1994 |
Growth hormone rapidly activates rat serine protease inhibitor 2.1 gene transcription and induces a DNA-binding activity distinct from those of Stat1, -3, and -4.
Topics: Animals; Base Sequence; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Growth Hormone; Male; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphotyrosine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serine Proteinase Inhibitors; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT4 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Tyrosine | 1995 |
Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI.
Topics: Amino Acid Sequence; Animals; Cell Compartmentation; Cell Line; Cell Membrane; Cloning, Molecular; Consensus Sequence; Enzyme Precursors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mast Cells; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptors, IgE; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship; Syk Kinase; Tyrosine | 1995 |
Tyrosine kinase specific motif at subdomain VIII does not confer specificity for tyrosine.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Genes, Synthetic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Substrate Specificity; Tyrosine | 1994 |
Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.
Topics: Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia; Amino Acid Sequence; Binding Sites; Conserved Sequence; Crystallography, X-Ray; DNA Transposable Elements; Humans; Models, Molecular; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphotyrosine; Point Mutation; Protein Structure, Secondary; Protein-Tyrosine Kinases; Sequence Deletion; Tyrosine; X Chromosome | 1994 |
Glycosylphosphatidylinositol toxin of Trypanosoma brucei regulates IL-1 alpha and TNF-alpha expression in macrophages by protein tyrosine kinase mediated signal transduction.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromatography, Thin Layer; Gene Expression; Glycosylphosphatidylinositols; Interleukin-1; Kinetics; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Time Factors; Trypanosoma brucei brucei; Tumor Necrosis Factor-alpha; Tyrosine; Variant Surface Glycoproteins, Trypanosoma | 1994 |
Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains.
Topics: Amino Acid Sequence; Catalysis; Enzyme Activation; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Ligands; Molecular Sequence Data; Peptides; Phosphotyrosine; Protein Conformation; Protein Tyrosine Phosphatases; Recombinant Proteins; Sequence Deletion; Structure-Activity Relationship; Tyrosine | 1994 |
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Disulfides; Erythropoietin; Immunosorbent Techniques; Interleukin-3; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mice; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Erythropoietin; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes.
Topics: Biological Transport; Cell Compartmentation; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Humans; In Vitro Techniques; Interleukin-2; Nuclear Proteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 1994 |
A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand.
Topics: Amino Acid Sequence; Animals; Base Sequence; Casein Kinases; Cell Line; Chromatography, Affinity; Cloning, Molecular; DNA, Complementary; Glutamic Acid; Humans; Ligands; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins pp60(c-src); RNA; Sequence Homology, Amino Acid; Serine; Tyrosine | 1994 |
The rat hepatic lectin 1 subunit of the rat asialoglycoprotein receptor is a phosphoprotein and contains phosphotyrosine.
Topics: Amino Acid Sequence; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Cells, Cultured; Humans; Lectins; Liver; Male; Molecular Sequence Data; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sequence Homology, Amino Acid; Tyrosine | 1994 |
Different roles for the Fc epsilon RI gamma chain as a function of the receptor context.
Topics: Amino Acid Sequence; Animals; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Interleukin-2; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Receptors, Antigen, T-Cell, alpha-beta; Receptors, IgE; Signal Transduction; Transfection; Tyrosine | 1995 |
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.
Topics: Amino Acid Sequence; CD3 Complex; Consensus Sequence; Cytoplasm; In Vitro Techniques; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1995 |
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
Topics: Humans; Interleukin-12; Interleukin-2; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Killer Cells, Natural; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Signal Transduction; T-Lymphocytes; TYK2 Kinase; Tyrosine | 1995 |
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.
Topics: Animals; Caseins; Cell Aggregation; Cells, Cultured; Extracellular Matrix; Female; Gene Expression Regulation, Developmental; Genistein; In Vitro Techniques; Integrins; Isoflavones; Mice; Phosphotyrosine; Prolactin; Receptor Aggregation; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1994 |
Ising model for cooperative processing of extracellular information by protein-tyrosine kinases and cell adhesion molecules.
Topics: Animals; Cell Adhesion Molecules; Enzyme Activation; Extracellular Matrix; Integrins; Models, Theoretical; Monte Carlo Method; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Signal Transduction; Tyrosine | 1994 |
Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA Probes; DNA, Complementary; Embryo, Mammalian; Gene Expression; Kidney; Mice; Molecular Sequence Data; Phosphotyrosine; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Recombinant Proteins; RNA; RNA-Directed DNA Polymerase; RNA, Messenger; Tyrosine | 1994 |
Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons.
Topics: Cell Nucleus; Cytosol; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon Type I; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Kinetics; Phosphorylation; Phosphotyrosine; Recombinant Proteins; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Tyrosine | 1995 |
Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.
Topics: Amino Acid Sequence; Animals; Armadillo Domain Proteins; Cell Adhesion; Consensus Sequence; Drosophila melanogaster; Drosophila Proteins; Glycogen Synthase Kinase 3; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Structure-Activity Relationship; Trans-Activators; Transcription Factors; Tyrosine; Wnt1 Protein | 1994 |
Protein tyrosine phosphorylation in Mycobacterium tuberculosis.
Topics: Antibodies, Monoclonal; Bacterial Proteins; Mycobacterium tuberculosis; Phosphorylation; Phosphotyrosine; Tyrosine | 1994 |
Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; B-Lymphocytes; Basement Membrane; CD2 Antigens; CD28 Antigens; CD3 Complex; Cell Line; Cytokines; Immunoblotting; Intestinal Mucosa; Leukocyte Common Antigens; Mice; Phosphotyrosine; T-Lymphocyte Subsets; Tyrosine | 1995 |
The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Cycle; Female; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Isoxazoles; Leflunomide; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Interleukin-2; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation.
Topics: Adenocarcinoma; Animals; Blotting, Western; Catechols; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Genistein; Humans; Isoflavones; Kinetics; Lung; Male; Molecular Weight; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic progenitor cell line U937.
Topics: Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Hydroquinones; Interleukin-13; Kinetics; Monocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1995 |
Increased tyrosine-phosphorylation of 55KDa proteins in beta-actin/Tec transgenic mice.
Topics: Actins; Animals; Blotting, Western; Chickens; Cytomegalovirus; Enhancer Elements, Genetic; Gene Expression; Globins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Weight; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Rabbits; Tyrosine | 1995 |
Acute neurite retraction triggered by lysophosphatidic acid: timing of the inhibitory effects of genistein.
Topics: Actins; Animals; Genistein; Glioma; Hybrid Cells; Immunohistochemistry; Isoflavones; Kinetics; Lysophospholipids; Mice; Neurites; Neuroblastoma; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Tyrosine | 1994 |
Increased protein tyrosine-phosphorylation in primary T-cells transduced with Tax1 of human T-cell leukemia virus type I.
Topics: Cell Line, Transformed; Cells, Cultured; Gene Products, tax; Human T-lymphotropic virus 1; Humans; Lymphocyte Activation; Phosphorylation; Phosphotyrosine; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tyrosine | 1995 |
Protein kinase C and insulin receptor beta-subunit serine phosphorylation in cultured foetal rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Enzyme Activation; Glucose; Glycogen; Insulin; Liver; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Swine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
1H and 31P NMR spectroscopy of phosphorylated model peptides.
Topics: Amino Acid Sequence; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphorus; Phosphoserine; Phosphothreonine; Phosphotyrosine; Structure-Activity Relationship; Tyrosine | 1994 |
MHC class I signaling in T cells leads to tyrosine kinase activity and PLC-gamma 1 phosphorylation.
Topics: Benzoquinones; Calcium; Histocompatibility Antigens Class I; Humans; Isoenzymes; Lactams, Macrocyclic; Leukocyte Common Antigens; Phospholipase C gamma; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Rifabutin; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1995 |
CD9 plays a role in Schwann cell migration in vitro.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Surface; Axons; Calcium; Cell Movement; Immunohistochemistry; Intracellular Membranes; Membrane Glycoproteins; Phosphotyrosine; Rats; Schwann Cells; Sciatic Nerve; Substrate Specificity; Tetraspanin 29; Tyrosine | 1995 |
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; ErbB Receptors; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Hybridomas; Mice; Molecular Sequence Data; Peptides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; ras Guanine Nucleotide Exchange Factors; ras Proteins; Receptors, Antigen, T-Cell; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; T-Lymphocytes; Tyrosine | 1995 |
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Fusion Proteins, gag-onc; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Humans; Oncogene Proteins; Oncogenes; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Restriction Mapping; Sequence Deletion; Spodoptera; Transfection; Tyrosine | 1995 |
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Base Sequence; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Chlorocebus aethiops; Electrophoresis, Gel, Two-Dimensional; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine | 1995 |
Differential expression of ARIA isoforms in the rat brain.
Topics: Animals; Base Sequence; Blotting, Northern; Brain; Cerebellum; Choline; Cloning, Molecular; Cranial Nerves; Gene Expression; Molecular Sequence Data; Motor Neurons; Nerve Tissue Proteins; Neuregulin-1; Neurons; Phosphorylation; Phosphotyrosine; Rats; Receptors, Cholinergic; RNA, Messenger; Spinal Cord; Telencephalon; Tissue Distribution; Tyrosine | 1995 |
Direct determination of the sequence recognition requirements of the SH2 domains of SH-PTP2.
Topics: Amino Acid Sequence; Binding, Competitive; Enzyme Activation; In Vitro Techniques; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphopeptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptor, Insulin; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1995 |
1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells.
Topics: Amino Acid Sequence; CDC2 Protein Kinase; Cytarabine; Humans; In Vitro Techniques; Leukemia, Myeloid; Macromolecular Substances; Molecular Sequence Data; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1995 |
Identification of the in vitro phosphorylation sites on Gs alpha mediated by pp60c-src.
Topics: Amino Acid Sequence; Animals; Birds; Cattle; Chromatography, High Pressure Liquid; GTP-Binding Proteins; Mice; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptors, Adrenergic, beta; Recombinant Proteins; Sequence Analysis; Signal Transduction; Trypsin; Tyrosine | 1995 |
Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Methylene Blue; Mice; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Oxyhemoglobins; Penicillamine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; S-Nitroso-N-Acetylpenicillamine; Tyrosine | 1995 |
Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.
Topics: Amino Acids; Blotting, Western; Cells, Cultured; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Monocytes; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, IgG; Signal Transduction; Syk Kinase; Tyrosine | 1995 |
Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antigens, CD; B-Lymphocytes; Cell Line; Cytokine Receptor gp130; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Interleukin-6; Membrane Glycoproteins; Mice; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cytokine; Receptors, Interleukin; Receptors, Interleukin-3; Receptors, Interleukin-6; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1995 |
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Antibodies; Cell Adhesion Molecules; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Exons; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Immunoblotting; Interleukin-3; Kinetics; Mice; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Recombinant Proteins; Stem Cell Factor; Transfection; Tyrosine | 1995 |
Regulation of vascular and gastric smooth muscle contractility by pervanadate.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blotting, Western; Calcium; Epidermal Growth Factor; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sodium; Stomach; Tyrosine; Vanadates | 1994 |
Sustained tyrosine phosphorylation of p140trkA in PC12h-R cells responding rapidly to NGF.
Topics: Animals; Choline O-Acetyltransferase; Clone Cells; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kinetics; Molecular Weight; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Tyrosine; Tyrosine 3-Monooxygenase | 1994 |
Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells.
Topics: Animals; Asbestos, Crocidolite; Blotting, Northern; Cell Division; Cell Line; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Mesothelioma; Peritoneal Neoplasms; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Rats; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1995 |
P62 association with RNA is regulated by tyrosine phosphorylation.
Topics: Base Sequence; DNA Primers; DNA-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; RNA; RNA-Binding Proteins; Signal Transduction; Tyrosine | 1995 |
Complete and reversible inhibition of NADPH oxidase in human neutrophils by phenylarsine oxide at a step distal to membrane translocation of the enzyme subunits.
Topics: Adenosine Triphosphate; Arsenicals; Cell Compartmentation; Cell Degranulation; Cell Membrane; Dimercaprol; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phagocytosis; Phosphotyrosine; Protein Tyrosine Phosphatases; Superoxides; Tyrosine | 1995 |
Biochemical properties of the ligand-binding 20-kDa subunit of the beta-glucan receptors on human mononuclear phagocytes.
Topics: Amino Acids; Binding Sites; Cell Line; Glucans; Humans; Isoelectric Point; Membrane Glycoproteins; Molecular Weight; Monocytes; Phosphotyrosine; Receptors, Immunologic; Tyrosine | 1995 |
Cell spreading in Colo 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of Src and tensin.
Topics: Alkaloids; Amino Acid Sequence; Cations, Divalent; Cell Adhesion; Extracellular Matrix; In Vitro Techniques; Integrins; Microfilament Proteins; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Very Late Antigen; Staurosporine; Tensins; Tumor Cells, Cultured; Tyrosine | 1995 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Mice; Mutation; Phosphoproteins; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tyrosine | 1995 |
Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Extracts; CHO Cells; Cricetinae; DNA, Complementary; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, fos; Genes, Reporter; GRB2 Adaptor Protein; Insulin; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; ras Proteins; Signal Transduction; Transcription, Genetic; Transfection; Tyrosine | 1995 |
src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Brain; Catalysis; Cattle; Circular Dichroism; Cloning, Molecular; Escherichia coli; Gene Expression; Molecular Sequence Data; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphotyrosine; Protein Structure, Secondary; Rats; Recombinant Proteins; Structure-Activity Relationship; Tyrosine | 1995 |
Alterations in expression of p56lck during myeloid differentiation of LSTRA cells.
Topics: Antigens, Differentiation; Bucladesine; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Cycle; Cell Differentiation; Cholecalciferol; Enzyme Induction; Granulocytes; Hematopoietic Stem Cells; Histocompatibility Antigens Class II; Humans; Leukemia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Phosphotryptic peptide analysis of the human androgen receptor: detection of a hormone-induced phosphopeptide.
Topics: Androgens; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Metribolone; Molecular Weight; Peptide Mapping; Phosphates; Phosphoproteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Receptors, Androgen; Trypsin; Tumor Cells, Cultured; Tyrosine | 1995 |
Chemical cross-linking of IgE-receptor complexes in RBL-2H3 cells.
Topics: Animals; Blotting, Western; Cell Membrane Permeability; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Immunoglobulin E; Immunosorbent Techniques; Leukemia, Basophilic, Acute; Macromolecular Substances; Mast Cells; Phosphorylation; Phosphotyrosine; Rats; Receptors, IgE; Succinimides; Tumor Cells, Cultured; Tyrosine | 1995 |
A primary T-cell immunodeficiency associated with defective transmembrane calcium influx.
Topics: Antigens, CD; Base Sequence; Biological Transport; Calcium; Cell Membrane; Cell Nucleus; DNA-Binding Proteins; Humans; Immunologic Deficiency Syndromes; Immunophenotyping; Infant; Interleukin-2; Ionomycin; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphatidylinositols; Phospholipids; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell, alpha-beta; Reference Values; Substrate Specificity; T-Lymphocytes; Tyrosine | 1995 |
Crk interacts with tyrosine-phosphorylated p116 upon T cell activation.
Topics: Adrenal Gland Neoplasms; Animals; Antigens, CD; CD4 Antigens; CD8 Antigens; Cell Line; Humans; Hybridomas; Kinetics; Lymphocyte Activation; Mice; Oncogene Protein v-crk; PC12 Cells; Pheochromocytoma; Phosphoproteins; Phosphotyrosine; Rats; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Recombinant Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; T-Lymphocytes; Tyrosine | 1995 |
Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains.
Topics: Amino Acid Sequence; Binding Sites; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Kinetics; Models, Structural; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Proteins; Sequence Homology, Amino Acid; Tyrosine | 1995 |
The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; ErbB Receptors; Humans; Kidney; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphotyrosine; Point Mutation; Protein Sorting Signals; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Sequence Deletion; Tyrosine | 1995 |
Identification and characterization of a functional murine FLT3 isoform produced by exon skipping.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; DNA Primers; Exons; fms-Like Tyrosine Kinase 3; Gene Expression; Humans; Kidney; Mice; Molecular Sequence Data; Molecular Weight; Phosphotyrosine; Polymerase Chain Reaction; Protein Conformation; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Transfection; Tyrosine | 1995 |
Matrix nonenzymatic glycosylation leads to altered cellular phenotype and intracellular tyrosine phosphorylation.
Topics: Animals; Basement Membrane; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycosylation; Humans; Kinetics; Mice; Mice, Inbred BALB C; Microcirculation; Neoplasms, Experimental; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Skin; Tyrosine | 1995 |
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
Topics: Animals; Binding Sites; Blotting, Northern; Cell Line; Gene Expression; Humans; Immunoblotting; Interferon Type I; Interferon-alpha; Interferon-beta; Kinetics; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Sequence Deletion; Signal Transduction; Transfection; TYK2 Kinase; Tyrosine | 1995 |
Lck unique domain influences Lck specificity and biological function.
Topics: Base Sequence; Cell Line; Cloning, Molecular; DNA Primers; Escherichia coli; Humans; Interleukin-2; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; Substrate Specificity; T-Lymphocytes; Transfection; Tyrosine | 1995 |
Defective phospholipase D activation in Ki-ras-transformed NIH3T3 cells: evidence for downstream effector of PLC-gamma 1 in PDGF-mediated signal transduction.
Topics: 1-Butanol; 3T3 Cells; Animals; Blotting, Western; Butanols; Cell Line, Transformed; Enzyme Activation; Enzyme Induction; Genes, ras; Glycerophospholipids; Inositol Phosphates; Kinetics; Mice; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipase D; Phosphoric Diester Hydrolases; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tyrosine | 1995 |
Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Topics: Amino Acid Sequence; Consensus Sequence; Crystallography, X-Ray; Isoenzymes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Solutions; Type C Phospholipases; Tyrosine | 1995 |
Rapid protein tyrosine phosphorylation in the cytoskeleton of stimulated human platelets.
Topics: Blood Platelets; Cell Membrane; Cytoskeleton; Humans; Phosphotyrosine; Platelet Activation; Proto-Oncogene Proteins pp60(c-src); Thrombin; Tyrosine; Vasopressins | 1995 |
The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal growth factor receptor.
Topics: Acid Phosphatase; Animals; Brain; Brain Chemistry; Cattle; ErbB Receptors; Immunochemistry; Molecular Weight; Phosphorylation; Phosphotyrosine; Rats; Tyrosine | 1994 |
The imidazole antimycotics econazole and miconazole reduce agonist-evoked protein-tyrosine phosphorylation and evoke membrane depolarisation in human platelets: cautions for their use in studying Ca2+ signalling pathways.
Topics: Adenosine Diphosphate; Benzothiazoles; Blood Platelets; Calcium; Carbocyanines; Cell Membrane; Cytochrome P-450 Enzyme Inhibitors; Econazole; Fluorescent Dyes; Humans; Membrane Potentials; Miconazole; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1994 |
Down-regulation of bradykinin receptors and bradykinin-induced Ca2+ mobilization, tyrosine phosphorylation, and DNA synthesis by autocrine factors, tumor necrosis factor alpha, and interferon beta in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bradykinin; Calcium; Cell Division; Culture Media; DNA; Down-Regulation; Growth Inhibitors; Interferon-beta; Mice; Phosphoproteins; Phosphotyrosine; Receptors, Bradykinin; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6).
Topics: Animals; Cell Count; Cell Division; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Genistein; Inositol Phosphates; Intestinal Mucosa; Isoenzymes; Isoflavones; Membrane Proteins; Phospholipase C gamma; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Type C Phospholipases; Tyrosine | 1995 |
Differential effects of phosphotyrosine phosphatase expression on hormone-dependent and independent pp60c-src activity.
Topics: Animals; Female; Humans; Immunoblotting; Mammary Neoplasms, Experimental; Mice; Multiple Myeloma; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1994 |
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Glycoproteins; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Neuregulins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Role of STAT2 in the alpha interferon signaling pathway.
Topics: Antibodies; Antibodies, Monoclonal; Cell Line; DNA-Binding Proteins; Genetic Complementation Test; Humans; Immunoblotting; Interferon Type I; Interferon-beta; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Binding; Recombinant Proteins; Signal Transduction; Transcription Factors; Transfection; Tyrosine | 1995 |
Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells.
Topics: Animals; Cell Line; Cell Membrane; Cytokines; Enzyme Precursors; Genetic Vectors; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Leukemia, Basophilic, Acute; Leukotrienes; Mast Cells; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Recombinant Fusion Proteins; Syk Kinase; Tumor Cells, Cultured; Tyrosine; Vaccinia virus | 1995 |
Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biotin; Blotting, Western; Cadherins; Cell Transformation, Neoplastic; Cytomegalovirus; Drosophila Proteins; Gene Expression Regulation, Neoplastic; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis, Site-Directed; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Simian virus 40; Transfection; Tyrosine | 1995 |
Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and SH2-independent.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cytoskeletal Proteins; ErbB Receptors; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Binding; Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1995 |
Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Cell Nucleus; Gene Deletion; Humans; Lymphocytes; Mice; Molecular Sequence Data; Mutagenesis; Phosphotyrosine; Plasmids; Protein Kinases; Receptors, Interleukin-2; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1995 |
Angiotensin II AT2 receptors are functionally coupled to protein tyrosine dephosphorylation in N1E-115 neuroblastoma cells.
Topics: Animals; Base Sequence; Cloning, Molecular; Dithiothreitol; DNA, Complementary; Gene Expression; Guanosine Triphosphate; Mice; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Angiotensin; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
The Ca2+ signaling capacity of the beta 2-integrin on HL60-granulocytic cells is abrogated following phosphorylation of its CD18-chain: relation to impaired protein tyrosine phosphorylation.
Topics: Calcium; CD18 Antigens; Cell Differentiation; Cell Line; Cytosol; Integrins; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Immunohistochemistry; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morphine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Time Factors; Tissue Distribution; Tyrosine | 1995 |
The crystal structures of the SH2 domain of p56lck complexed with two phosphonopeptides suggest a gated peptide binding site.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Models, Molecular; Molecular Sequence Data; Peptides; Phenylalanine; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Selective phosphoamino acid enrichment by organic solvent fractionation.
Topics: Acetone; Chemical Fractionation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1994 |
[The expression of C-FOS, C-JUN and phosphotyrosine gene products in lung cancer].
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Gene Expression; Humans; Lung Neoplasms; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tyrosine | 1994 |
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Base Sequence; DNA; DNA-Binding Proteins; Gene Expression Regulation; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-6; Isoquinolines; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoserine; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rats; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 1995 |
Distinct domains of the CD3-gamma chain are involved in surface expression and function of the T cell antigen receptor.
Topics: CD3 Complex; Cell Line; Down-Regulation; Humans; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Transfection; Tyrosine | 1995 |
Non-radioactive method to measure CD45 protein tyrosine phosphatase activity isolated directly from cells.
Topics: Amino Acid Sequence; Blotting, Western; Hydrogen-Ion Concentration; Kinetics; Leukocyte Common Antigens; Molecular Sequence Data; Peptides; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Substrate Specificity; Tyrosine | 1995 |
Angiogenesis: role of calcium-mediated signal transduction.
Topics: Aminoimidazole Carboxamide; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Extracellular Matrix Proteins; Fibroblast Growth Factor 2; Gelatinases; Humans; In Vitro Techniques; Laminin; Matrix Metalloproteinase 2; Metalloendopeptidases; Neovascularization, Pathologic; Phosphotyrosine; Proteoglycans; Signal Transduction; Triazoles; Tyrosine | 1995 |
A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Lactation; Mice; Mice, Mutant Strains; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1995 |
Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.
Topics: Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; RNA Polymerase II; Substrate Specificity; Tyrosine | 1995 |
Integrin and phosphotyrosine expression in normal and migrating newt keratinocytes.
Topics: Animals; Cell Movement; Collagen; Fibronectins; Integrins; Keratinocytes; Male; Microscopy, Fluorescence; Notophthalmus viridescens; Phosphotyrosine; Tyrosine; Wound Healing | 1995 |
Specificity in recognition of phosphopeptides by src-homology 2 domains.
Topics: Amino Acid Sequence; Binding Sites; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1994 |
Tyrosine phosphorylation induced by cross-linking of Fc gamma-receptor type II in human neutrophils.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Ethers, Cyclic; Genistein; Humans; Isoflavones; Molecular Sequence Data; Neutrophils; Okadaic Acid; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Respiratory Burst; Tyrosine; Virulence Factors, Bordetella | 1995 |
Differential phosphorylation of a 57-KDa protein tyrosine kinase during egg activation.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Female; Fertilization; Genes, src; Male; Molecular Sequence Data; Molecular Weight; Oocytes; Peptides; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Sea Urchins; Spermatozoa; Tyrosine | 1995 |
High affinity chimeric human granulocyte-macrophage colony-stimulating factor receptor carrying the cytoplasmic domain of the beta subunit but not the alpha subunit transduces growth promoting signals in Ba/F3 cells.
Topics: Animals; B-Lymphocytes; Blotting, Northern; Cell Division; Cell Line; Gene Expression; Genes, Immediate-Early; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Kinetics; Macromolecular Substances; Mice; Phosphoproteins; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Recombinant Proteins; RNA, Messenger; Signal Transduction; Transfection; Tyrosine | 1995 |
A phosphotyrosine interaction domain.
Topics: Amino Acid Sequence; Animals; Consensus Sequence; Humans; Molecular Sequence Data; Phosphotyrosine; Proteins; Tyrosine | 1995 |
Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.
Topics: 3T3 Cells; Amino Acid Sequence; Amino Acids; Animals; Base Sequence; Binding Sites; Conserved Sequence; CSK Tyrosine-Protein Kinase; DNA Mutational Analysis; Down-Regulation; Gene Expression Regulation, Enzymologic; Genes, Lethal; Ligands; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Schizosaccharomyces; src-Family Kinases; Tyrosine | 1995 |
Tyrosine phosphorylation in the human duodenum.
Topics: CD3 Complex; Celiac Disease; Duodenum; Edetic Acid; Epidermal Growth Factor; Flow Cytometry; Humans; Immunoenzyme Techniques; Phosphorylation; Phosphotyrosine; Tyrosine | 1995 |
The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Cricetinae; Interleukin-3; Janus Kinase 2; Kinetics; Mice; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Immunologic; Receptors, Thrombopoietin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Thrombopoietin; Transfection; Tyrosine | 1995 |
The rabbit mammary gland prolactin receptor is tyrosine-phosphorylated in response to prolactin in vivo and in vitro.
Topics: Adenosine Triphosphate; Animals; Antibodies; Antibodies, Monoclonal; Azides; Blotting, Western; CHO Cells; Cricetinae; Female; Janus Kinase 2; Lactation; Macromolecular Substances; Mammary Glands, Animal; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rabbits; Receptors, Prolactin; Recombinant Proteins; Transfection; Tyrosine | 1995 |
Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk.
Topics: 3T3 Cells; Animals; Carcinoma, Embryonal; Cell Line; Humans; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptor, IGF Type 1; Tumor Cells, Cultured; Tyrosine | 1995 |
Role of p70 S6 protein kinase in angiotensin II-induced protein synthesis in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Imidazoles; Kinetics; Losartan; Male; Molecular Weight; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred BN; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; Sirolimus; Tetrazoles; Tyrosine | 1995 |
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; ErbB Receptors; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Receptors, Erythropoietin; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1995 |
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
Topics: Animals; Cattle; Insulin; Insulin Receptor Substrate Proteins; Liver; Male; Mice; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, Insulin; Substrate Specificity; Tyrosine | 1995 |
v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Survival; Clone Cells; Enzyme Activation; Genes, abl; Glycogen Synthase Kinase 3; GTPase-Activating Proteins; Humans; Interleukin-3; Kinetics; Mitogen-Activated Protein Kinase Kinases; Mutagenesis; Oncogene Proteins v-abl; Phosphorylation; Phosphotyrosine; Protein Kinases; Proteins; Temperature; Transfection; Type C Phospholipases; Tyrosine | 1995 |
A 40-amino acid segment of the growth hormone receptor cytoplasmic domain is essential for GH-induced tyrosine-phosphorylated cytosolic proteins.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Base Sequence; Cattle; Cytosol; Growth Hormone; Humans; L Cells; Mice; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rabbits; Rats; Receptors, Somatotropin; Recombinant Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Swine; Transfection; Tyrosine | 1995 |
Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Blotting, Western; Cattle; Cell Line; Chromatography, Affinity; Cloning, Molecular; Coated Pits, Cell-Membrane; ErbB Receptors; Humans; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenylalanine; Phosphorylation; Phosphotyrosine; Protein Binding; Recombinant Proteins; Sequence Deletion; Tumor Cells, Cultured; Tyrosine | 1995 |
Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.
Topics: 3T3 Cells; Adult; Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Ephrin-B2; Female; Fetal Blood; Fetus; Glomerular Mesangium; Hematopoietic Stem Cells; Humans; Kidney; Kinetics; Ligands; Male; Membrane Proteins; Mice; Molecular Sequence Data; Organ Specificity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pregnancy; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Transfection; Tyrosine | 1995 |
Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Drug Synergism; Enzyme Activation; Ethanol; Fibroblast Growth Factor 2; Isoenzymes; Kinetics; Molecular Sequence Data; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Molecular identities of human sperm proteins that bind human zona pellucida: nature of sperm-zona interaction, tyrosine kinase activity, and involvement of FA-1.
Topics: Antigens; Blotting, Western; Carrier Proteins; Electrophoresis, Polyacrylamide Gel; Female; Glycoproteins; Humans; Iodine Radioisotopes; Male; Molecular Weight; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Sperm-Ovum Interactions; Spermatozoa; Tyrosine; Zona Pellucida | 1994 |
Rat fibroblast cells overexpressing kinase-inactive human insulin receptors are insulin responsive: influence of growth conditions.
Topics: Animals; Biological Transport; Cell Line; Deoxyglucose; DNA; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Glucose; Glycogen Synthase; Humans; Insulin; Insulin-Like Growth Factor I; Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1995 |
Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Fibroblasts; Glycoproteins; Mice; Neuregulins; Oncogenes; Phosphotyrosine; Receptor, ErbB-2; Tyrosine | 1995 |
Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction.
Topics: Acetylcholine; Animals; Binding Sites; Cytoskeletal Proteins; Dogs; Immunosorbent Techniques; Muscle Contraction; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Talin; Trachea; Tyrosine; Vinculin | 1995 |
Dual modulation of phosphorylation of a 60 kDa nuclear protein in interferon-alpha treated Daudi cells.
Topics: B-Lymphocytes; Cell Line; Humans; Interferon alpha-2; Interferon-alpha; Molecular Weight; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tyrosine | 1995 |
Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells.
Topics: Animals; Antigen-Presenting Cells; CD3 Complex; CD4 Antigens; CD4-Positive T-Lymphocytes; Female; Histocompatibility Antigens Class II; Immunologic Memory; Interferon-gamma; Interleukin-4; L Cells; Leukocyte Common Antigens; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphotyrosine; Signal Transduction; Tyrosine | 1995 |
Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate.
Topics: Cell Division; HLA-DR Antigens; Humans; In Vitro Techniques; Interferon-gamma; Leukocytes, Mononuclear; Lymphocyte Activation; Phosphoproteins; Phosphotyrosine; Receptors, Interleukin-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.
Topics: Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Drosophila; Female; Gene Expression Regulation, Enzymologic; Genes, abl; Genes, Insect; Genes, Suppressor; Humans; Male; Molecular Sequence Data; Nervous System; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Analysis, DNA; Substrate Specificity; Tyrosine | 1995 |
Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor.
Topics: Amino Acid Sequence; Cell Line; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Macromolecular Substances; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Erythropoietin; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Tyrosine | 1995 |
Integrin-linked tyrosine phosphorylation increases membrane association of protein kinase C alpha in pancreatic acinar cells.
Topics: Animals; Blotting, Western; Cell Membrane; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Integrin beta1; Integrins; Isoenzymes; Male; Microscopy, Fluorescence; Pancreas; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Rats, Wistar; Tyrosine | 1995 |
Intracellular tyrosine residues of the human growth hormone receptor are not required for the signaling of proliferation or Jak-STAT activation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Cysteine; Humans; Interleukin-3; Janus Kinase 2; Mice; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; Trans-Activators; Transcription Factors; Transfection; Tyrosine | 1995 |
Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.
Topics: 3T3 Cells; Animals; Carrier Proteins; Cell Division; Culture Media, Serum-Free; Dexamethasone; ErbB Receptors; Fibroblasts; Glycoproteins; Growth Substances; Mice; Neuregulin-1; Peptide Fragments; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Recombinant Proteins; Thymidine; Transfection; Tyrosine | 1995 |
Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Dual-Specificity Phosphatases; Female; HeLa Cells; Humans; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Phosphatases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphothreonine; Phosphotyrosine; Placenta; Pregnancy; Protein Tyrosine Phosphatases; Sequence Homology, Amino Acid; Substrate Specificity; Transfection; Tyrosine | 1995 |
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Enzyme Activation; HeLa Cells; Humans; Inflammation; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Osmolar Concentration; Phosphorylation; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Sequence Deletion; Stress, Physiological; Subcellular Fractions; Substrate Specificity; Threonine; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation.
Topics: Alkaloids; Animals; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tyrosine; Up-Regulation | 1995 |
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; GRB2 Adaptor Protein; Growth Hormone; Humans; Janus Kinase 2; Kidney; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Recombinant Proteins; Transfection; Tyrosine | 1995 |
HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Bacterial Toxins; Base Sequence; Breast Neoplasms; Cell Line; Cell Survival; DNA Primers; ErbB Receptors; Exotoxins; Female; Gene Expression; Glycoproteins; Humans; Immunotoxins; Kidney; Kinetics; Leukemia, T-Cell; Lung Neoplasms; Male; Molecular Sequence Data; Neuregulins; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Prostatic Neoplasms; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rats; Receptor, ErbB-4; Recombinant Fusion Proteins; RNA, Messenger; Tumor Cells, Cultured; Tyrosine; Virulence Factors | 1995 |
Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin.
Topics: Adenosine Triphosphate; Cell Cycle Proteins; Cell Line; Glutathione Transferase; Humans; Insulin; Multiple Myeloma; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tyrosine | 1995 |
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Blotting, Western; Cell Line; Cytosol; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Kinetics; Macromolecular Substances; Phosphotyrosine; Pioglitazone; Protein Tyrosine Phosphatases; Raffinose; Rats; Receptor, Insulin; Recombinant Proteins; Swine; Thiazoles; Thiazolidinediones; Transfection; Tyrosine | 1995 |
Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts.
Topics: Alkaloids; Animals; Catechols; Cell Survival; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Genistein; Isoflavones; Kinetics; L Cells; Mice; Nitriles; Phenols; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Transforming Growth Factor beta; Tumor Protein, Translationally-Controlled 1; Tyrosine; Tyrphostins | 1995 |
Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.
Topics: Amino Acid Sequence; Animals; Aorta; Base Sequence; Becaplermin; Binding, Competitive; Cell Division; Endothelium, Vascular; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Fragments; Phospholipases; Phosphopeptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Proto-Oncogene Proteins c-sis; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Sequence Homology, Amino Acid; Swine; Thymidine; Tyrosine | 1995 |
Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.
Topics: Animals; Apoptosis; Calcium; CDC2 Protein Kinase; Cell Nucleus; DNA Damage; Lamin Type B; Lamins; Methylprednisolone; Mice; Mice, Inbred BALB C; Nuclear Proteins; Nucleosomes; Phosphotyrosine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors; Tyrosine | 1995 |
The Fc gamma RI receptor signals through the activation of hck and MAP kinase.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Humans; In Vitro Techniques; Interferons; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Receptors, IgG; Signal Transduction; Tyrosine | 1995 |
Binding of a growth hormone-inducible nuclear factor is mediated by tyrosine phosphorylation.
Topics: Animals; Antibodies; Blotting, Western; Cell Nucleus; DNA; DNA-Binding Proteins; Growth Hormone; Hypophysectomy; Liver; Male; Nuclear Proteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1994 |
Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathways.
Topics: Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Chick Embryo; Chickens; Enzyme Activation; Fibroblasts; Gene Expression; Genes, ras; Genes, src; Oncogene Protein pp60(v-src); Oncogene Proteins v-raf; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins, Oncogenic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunohistochemistry; Kinetics; Mice; Phosphotyrosine; Placenta; Placental Lactogen; Pregnancy; Rats; Recombinant Proteins; Transforming Growth Factor alpha; Tyrosine | 1995 |
In vivo and in vitro serine/threonine phosphorylations of epidermal growth factor receptor upon entry into the cell cycle.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Culture Media, Serum-Free; Electrophoresis, Gel, Two-Dimensional; ErbB Receptors; Flow Cytometry; Glioblastoma; Humans; Interphase; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; S Phase; Tyrosine | 1995 |
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.
Topics: 3T3 Cells; Actins; Animals; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fungal Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; Membrane Proteins; Mice; Microinjections; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pseudopodia; rac GTP-Binding Proteins; Recombinant Fusion Proteins; rhoB GTP-Binding Protein; Signal Transduction; Tyrosine; Vinculin | 1995 |
Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cesarean Section; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Kinetics; Myometrium; Oxytocin; Phosphorylation; Phosphotyrosine; Postpartum Period; Pregnancy; Ritodrine; Tyrosine | 1995 |
Nerve growth factor stimulates tyrosine phosphorylation of paxillin in PC12h cells.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Immunosorbent Techniques; Kinetics; Nerve Growth Factors; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Signal Transduction; Tyrosine | 1995 |
Phosphatase resistance of ERK2 brain kinase PK40erk2.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Amino Acid Sequence; Animals; Brain; Cattle; Drug Resistance; Enzyme Activation; Isoenzymes; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Phosphates; Phosphoprotein Phosphatases; Phosphoserine; Phosphotyrosine; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Tyrosine | 1995 |
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
Topics: Aging; Animals; Blotting, Northern; Choline O-Acetyltransferase; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Situ Hybridization; Nerve Growth Factors; Phosphotyrosine; Prosencephalon; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Tyrosine | 1995 |
Effects of chromium on basal and insulin-induced tyrosine phosphorylation in H4 hepatoma cells: comparison with phorbol-12-myristate-13-acetate and sodium orthovanadate.
Topics: Animals; Chromium; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Calorimetry; Glutathione Transferase; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1995 |
Tyrosine- versus serine-phosphorylation leads to conformational changes in a synthetic tau peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies, Monoclonal; Genes, Synthetic; Humans; Immunodominant Epitopes; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Conformation; Protein Processing, Post-Translational; Spectroscopy, Fourier Transform Infrared; tau Proteins; Tyrosine | 1994 |
Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-A resolution.
Topics: Acid Phosphatase; Amino Acid Sequence; Animals; Arginine; Binding Sites; Cattle; Computer Graphics; Crystallography, X-Ray; Cysteine; Erythrocytes; Humans; Isoenzymes; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardium; Phosphotyrosine; Protein Folding; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Recombinant Proteins; Sequence Homology, Amino Acid; Tyrosine | 1994 |
Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.
Topics: Alkaloids; Blood Platelets; Calcium; Crotalid Venoms; Epoprostenol; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Staurosporine; Tyrosine; von Willebrand Factor | 1995 |
Interleukin-3 signals through multiple isoforms of Stat5.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA-Binding Proteins; Gene Library; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Mice; Milk Proteins; Molecular Sequence Data; Oligonucleotide Probes; Peptide Fragments; Phosphotyrosine; Sequence Homology, Amino Acid; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 1995 |
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
Topics: Adolescent; Base Sequence; Blotting, Western; Cell Line; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibrosarcoma; Humans; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Mutagenesis; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1995 |
Phosphorylation of human plasminogen activators and plasminogen.
Topics: Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Humans; Immunoblotting; Melanoma; Phosphorylation; Phosphoserine; Phosphotyrosine; Plasminogen; Plasminogen Activators; Tissue Plasminogen Activator; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1995 |
Monoclonal antibodies against the acetylcholine receptor gamma-subunit as site specific probes for receptor tyrosine phosphorylation.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Epitope Mapping; Epitopes; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Rats; Receptors, Cholinergic; Torpedo; Tyrosine | 1995 |
Determination of receptor-ligand kinetic and equilibrium binding constants using surface plasmon resonance: application to the lck SH2 domain and phosphotyrosyl peptides.
Topics: Amino Acid Sequence; Binding, Competitive; Kinetics; Ligands; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Peptides; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Spectrum Analysis; Tyrosine | 1995 |
Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Peptides; Phosphotyrosine; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1995 |
Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship; Tyrosine | 1995 |
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1995 |
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.
Topics: Base Sequence; Binding Sites; Blotting, Western; DNA-Binding Proteins; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Interferon-alpha; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
Regulation of CD45 engagement by the B-cell receptor CD22.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; beta-D-Galactoside alpha 2-6-Sialyltransferase; Calcium; Cell Adhesion Molecules; Cell Line; Humans; Inositol Phosphates; Isoenzymes; Kinetics; Lectins; Leukocyte Common Antigens; Phosphorylation; Phosphotyrosine; Receptor-CD3 Complex, Antigen, T-Cell; Sialic Acid Binding Ig-like Lectin 2; Sialyltransferases; Type C Phospholipases; Tyrosine | 1995 |
A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription.
Topics: Caseins; Clone Cells; Gene Expression Regulation; Humans; Janus Kinase 2; Luciferases; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Recombinant Proteins; Transcription, Genetic; Transfection; Tyrosine | 1995 |
Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites.
Topics: Animals; Cell Division; Cell Line, Transformed; Cricetinae; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Linoleic Acid; Linoleic Acids; Mesocricetus; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1995 |
On the mechanism of activation of PLA2 and PtdIns-PLC by fluoride in murine macrophages.
Topics: Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Deferoxamine; Enzyme Activation; Kinetics; Macrophages; Mice; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Phosphotyrosine; Protein-Tyrosine Kinases; Sodium Fluoride; Tyrosine | 1995 |
Alpha 1 B, but not alpha 1A, adrenoreceptor activates calcium influx through the stimulation of a tyrosine kinase/phosphotyrosine phosphatase pathway, following noradrenaline-induced emptying of IP3 sensitive calcium stores, in PC Cl3 rat thyroid cell lin
Topics: Animals; Calcium; Cells, Cultured; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Norepinephrine; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, Adrenergic, alpha; Signal Transduction; Thyroid Gland; Tyrosine; Vanadates | 1995 |
The amino acid sequence GPLY is not necessary for normal endocytosis of the human insulin receptor B isoform.
Topics: Amino Acid Sequence; Base Sequence; DNA Primers; Endocytosis; Humans; Insulin; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Sequence Deletion; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1995 |
Protein-tyrosine phosphatase inhibition by a peptide containing the phosphotyrosyl mimetic, L-O-malonyltyrosine.
Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Protein Conformation; Protein Tyrosine Phosphatases; Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine | 1995 |
The E-cadherin complex contains the src substrate p120.
Topics: alpha Catenin; Animals; Antibodies; beta Catenin; Cadherins; Cell Line; Concanavalin A; Cytoskeletal Proteins; Dogs; Electrophoresis, Polyacrylamide Gel; Genes, src; Genetic Vectors; Kidney; Methionine; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Retroviridae; Trans-Activators; Transfection; Tyrosine | 1995 |
Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Enzyme Activation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Peptide Fragments; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Signal Transduction; Syk Kinase; Tyrosine | 1995 |
The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane.
Topics: 3T3 Cells; Animals; Base Sequence; Cytoplasm; DNA Primers; Fluorescent Antibody Technique; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction.
Topics: Amino Acid Sequence; Caseins; Cell Line; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Janus Kinase 2; Molecular Sequence Data; Multigene Family; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Recombinant Proteins; Sequence Alignment; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Transfection; Tyrosine | 1995 |
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling.
Topics: Animals; Blood Glucose; Colchicine; Diaphragm; Endocytosis; Endosomes; Enzyme Activation; Insulin; Liver; Organometallic Compounds; Phenanthrolines; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 1995 |
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Consensus Sequence; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Molecular Sequence Data; Phosphotyrosine; Protein Binding; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Ubiquitin-Protein Ligases | 1995 |
A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor.
Topics: Animals; Antigens; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Cycle Proteins; Cell Line; Enzyme Activation; Enzyme Precursors; GTP-Binding Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mast Cells; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Rats; Receptor Aggregation; Receptors, IgE; Receptors, Muscarinic; Recombinant Proteins; Signal Transduction; Swine; Syk Kinase; Transfection; Tyrosine | 1995 |
The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Gene Expression; Genes, fos; GTP-Binding Proteins; Insulin; Intracellular Signaling Peptides and Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Receptors, Thrombin; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Becaplermin; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1995 |
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Topics: Adult; Biological Transport; Biopsy; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Muscle, Skeletal; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, Insulin; Reference Values; Tyrosine | 1995 |
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cloning, Molecular; Humans; Insulin Receptor Substrate Proteins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphotyrosine; Proteins; Receptor, Insulin; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1995 |
Hepatocyte growth factor specifically expressed in microglia activated Ras in the neurons, similar to the action of neurotrophic factors.
Topics: Animals; Brain; Fibroblast Growth Factor 2; Gene Expression; Genes, ras; Hepatocyte Growth Factor; Microglia; Neurons; Phosphotyrosine; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins p21(ras); Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tyrosine | 1995 |
Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice.
Topics: Animals; Base Sequence; Clone Cells; DNA Primers; Female; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Genes, abl; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, T-Cell; Male; Metallothionein; Mice; Mice, Transgenic; Molecular Sequence Data; Pedigree; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; RNA, Messenger; Tissue Distribution; Tyrosine | 1995 |
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; B-Lymphocytes; Cell Line; Cytokine Receptor gp130; Enzyme Activation; Humans; Immunoblotting; Interleukin-6; Kinetics; Macromolecular Substances; Membrane Glycoproteins; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; Proto-Oncogenes; Receptors, Interleukin; Receptors, Interleukin-6; Signal Transduction; Tyrosine | 1995 |
Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
Topics: Animals; Base Sequence; Blotting, Western; Cell Division; Cell Line; DNA Primers; Enzyme Activation; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Tyrosine | 1995 |
Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Actins; Animals; Aorta; Becaplermin; Cell Adhesion Molecules; Cell Division; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kinetics; Mice; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Receptor, Insulin; Recombinant Proteins; Tunica Media; Tyrosine | 1995 |
Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Chlorocebus aethiops; Consensus Sequence; Enzyme Activation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Kinetics; Mice; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; Syk Kinase; Transfection; Tyrosine | 1995 |
Homology requirements for ligation and strand exchange by the FLP recombinase.
Topics: Base Composition; Base Sequence; Binding Sites; DNA Nucleotidyltransferases; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phosphotyrosine; Plasmids; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1995 |
Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets.
Topics: Adult; Biological Transport; Blood Platelets; Blood Proteins; Calpain; Cytochalasin D; Cytoskeleton; Gene Expression Regulation, Enzymologic; Humans; Integrins; Isoenzymes; Models, Biological; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Subcellular Fractions; Thrombasthenia; Thrombin; Tyrosine | 1995 |
An incomplete program of cellular tyrosine phosphorylations induced by kinase-defective epidermal growth factor receptors.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Activation; ErbB Receptors; GRB2 Adaptor Protein; GTPase-Activating Proteins; Humans; Janus Kinase 2; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Topics: 3T3 Cells; Agammaglobulinaemia Tyrosine Kinase; Animals; B-Lymphocytes; Base Sequence; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression; Mice; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.
Topics: Amino Acid Sequence; Antigens, CD; Calcium; CD3 Complex; CD79 Antigens; Genetic Complementation Test; Humans; Interleukin-2; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Structure-Activity Relationship; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1995 |
Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells.
Topics: Drug Resistance, Multiple; Humans; In Vitro Techniques; Lung Neoplasms; Phosphotyrosine; Receptor, ErbB-2; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering.
Topics: B-Lymphocytes; Child; Humans; Interleukin-4; Janus Kinase 2; Janus Kinase 3; Lymphocyte Activation; Palatine Tonsil; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interleukin; Receptors, Interleukin-4; Signal Transduction; Tyrosine | 1995 |
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.
Topics: 3T3 Cells; Animals; Base Sequence; Breast Neoplasms; Cell Transformation, Neoplastic; DNA Primers; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, erbB; Glycoproteins; Ligands; Mice; Molecular Sequence Data; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Aggregation; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tyrosine | 1995 |
Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Topics: Animals; Base Sequence; Caseins; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Liver; Mice; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Processing, Post-Translational; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Line; DNA Primers; Enzyme Activation; Humans; Hydrogen Peroxide; Leukemia, T-Cell; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes.
Topics: Animals; Calcium; Enzyme Precursors; Hydrogen Peroxide; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lymphocytes; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Swine; Syk Kinase; Type C Phospholipases; Tyrosine | 1995 |
Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells.
Topics: Animals; Aorta; Calmodulin-Binding Proteins; Cell Separation; Ferrets; Fluorescent Antibody Technique; Image Processing, Computer-Assisted; Immunoblotting; Microscopy; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Tyrosine | 1995 |
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A.
Topics: Animals; Benzoquinones; Cell Line; Dithiothreitol; Interleukin-1; Lactams, Macrocyclic; Mercaptoethanol; Mice; NF-kappa B; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
LHRH-induced tyrosine phosphorylation and MAP kinase activation in alpha T3-1 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Gonadotropin-Releasing Hormone; Immunoblotting; Indoles; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, LHRH; Signal Transduction; Tyrosine | 1995 |
Tyrosine phosphorylations specific to mitosis in human and hamster cells.
Topics: Animals; Antibodies; Cell Cycle; Cell Line; Cricetinae; Flow Cytometry; G1 Phase; G2 Phase; HeLa Cells; Humans; Immunoblotting; Kinetics; Mesocricetus; Mitosis; Phosphoproteins; Phosphorylation; Phosphotyrosine; S Phase; Tyrosine | 1995 |
Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.
Topics: Antigens, CD; CD4 Antigens; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Syk Kinase; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1995 |
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.
Topics: Animals; B-Lymphocytes; Cell Line; Cells, Cultured; Crosses, Genetic; Female; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Lymphocyte Activation; Lymphoma; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Signal Transduction; Spleen; Tyrosine | 1995 |
Rescue from granzyme B-induced apoptosis by Wee1 kinase.
Topics: Animals; Apoptosis; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cricetinae; Genes, myc; Granzymes; Homeostasis; Humans; Kidney; Mitosis; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Serine Endopeptidases; Transfection; Tyrosine | 1995 |
Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
Topics: Animals; Breast Neoplasms; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Multigene Family; Neoplasm Proteins; Nucleopolyhedroviruses; Phosphorylation; Phosphotyrosine; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptors, Estrogen; Recombinant Proteins; Spodoptera; Tumor Cells, Cultured; Tyrosine | 1995 |
Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Caenorhabditis elegans; Cell Nucleus; Cytoplasm; Genes, abl; Genes, Helminth; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-abl; Transfection; Tyrosine | 1995 |
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
Topics: Animals; Antigens, CD; Cardiomegaly; Cells, Cultured; Cytokine Receptor gp130; Gene Expression; Humans; Interleukin-6; Membrane Glycoproteins; Mice; Mice, Transgenic; Myocardium; Phosphorylation; Phosphotyrosine; Receptors, Interleukin; Receptors, Interleukin-6; Signal Transduction; Transcription, Genetic; Tyrosine | 1995 |
Ganglioside GM1 binds to the Trk protein and regulates receptor function.
Topics: Animals; Cell Differentiation; G(M1) Ganglioside; Kinetics; Nerve Growth Factors; Neurites; Neurofilament Proteins; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Tyrosine | 1995 |
PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Cell Line; Humans; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Binding; Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Lack of critical domains in the beta-chain of hepatocyte growth factor.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Dogs; Hepatocyte Growth Factor; Humans; Liver; Liver Neoplasms; Macromolecular Substances; Mice; Mutagenesis; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; Spodoptera; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Cricetinae; Cytosol; Durapatite; Enzyme Activation; Immunoblotting; Isoenzymes; Kinetics; Molecular Sequence Data; Phorbol 12,13-Dibutyrate; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
An inward rectifier K+ current modulates in neuroblastoma cells the tyrosine phosphorylation of the pp125FAK and associated proteins: role in neuritogenesis.
Topics: Animals; Benzoquinones; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lactams, Macrocyclic; Membrane Potentials; Mice; Neoplasm Proteins; Neurites; Neuroblastoma; Patch-Clamp Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein-Tyrosine Kinases; Quinones; Receptor, Insulin; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1995 |
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Indomethacin; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphotyrosine; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 1995 |
Evidence of redox-linked signaling for producing a giant signal complex.
Topics: Animals; Blood Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Centrifugation; Cross-Linking Reagents; GTPase-Activating Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mercuric Chloride; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Plant Oils; Polyethylene Glycols; Protein-Tyrosine Kinases; Proteins; Signal Transduction; Tyrosine | 1995 |
Insulin-like growth factor-1 enhances epidermal growth factor receptor activation and renal tubular cell regeneration in postischemic acute renal failure.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Blood Pressure; Body Weight; DNA; Epidermal Growth Factor; ErbB Receptors; Insulin-Like Growth Factor I; Iodine Radioisotopes; Ischemia; Kidney Medulla; Kidney Tubules; Male; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Regeneration; Renal Circulation; Tyrosine | 1995 |
Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Insulin; Liver; Liver Neoplasms, Experimental; Molecular Sequence Data; Molecular Weight; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1995 |
High-sensitivity determination of tyrosine-phosphorylated peptides by on-line enzyme reactor and electrospray ionization mass spectrometry.
Topics: Amino Acid Sequence; Biotin; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 1995 |
Cisplatin stimulates protein tyrosine phosphorylation in macrophages.
Topics: Animals; Cell Line; Cisplatin; Enzyme Activation; Fluorescent Antibody Technique; Genistein; Isoflavones; Kinetics; Lipopolysaccharides; Macrophage Activation; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenols; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Induction of protein tyrosine phosphorylation in macrophages incubated with tumor cells.
Topics: Animals; Cell Line; Fluorescent Antibody Technique; Immunoblotting; Macrophage Activation; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1995 |
A new approach to phosphoserine, phosphothreonine and phosphotyrosine synthons and to thiophospho analogs. Stepwise synthesis of mono- and multiphosphorylated phosphopeptides related to src-protein kinase.
Topics: Amino Acid Sequence; CSK Tyrosine-Protein Kinase; Molecular Sequence Data; Organothiophosphates; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 1995 |
A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; GRB2 Adaptor Protein; Humans; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptors, Antigen, T-Cell; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1995 |
Amino acid residues in the third alpha-helix of growth hormone involved in growth promoting activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Growth Hormone; Insulin-Like Growth Factor I; L Cells; Mice; Mice, Transgenic; Molecular Sequence Data; Mutagenesis; Phosphotyrosine; Protein Structure, Secondary; Radioligand Assay; Recombinant Proteins; Structure-Activity Relationship; Tyrosine | 1995 |
Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling.
Topics: Amino Acid Sequence; Base Sequence; Cell Division; Cell Line; Gene Expression; Growth Hormone; Humans; Immunosorbent Techniques; Janus Kinase 2; Macromolecular Substances; Molecular Sequence Data; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1995 |
Herbimycin A inhibits phorbol ester-induced morphologic changes, adhesion, and megakaryocytic differentiation of the leukemia cell line, MEG-01.
Topics: Benzoquinones; Cell Adhesion; Cell Differentiation; Genes, fos; Genes, jun; Humans; Lactams, Macrocyclic; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Naphthalenes; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Evidence against dephosphorylation of insulin-elicited phosphotyrosine proteins in vivo by the phosphatase PTP2C.
Topics: Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Insulin; Intracellular Signaling Peptides and Proteins; Kidney; Molecular Weight; Phosphoproteins; Phosphotyrosine; Point Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Proteins; Tyrosine | 1995 |
In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase.
Topics: Base Sequence; Binding Sites; Cell Line; DNA Primers; Gene Products, nef; Genes, nef; Glutathione Transferase; HIV-1; Humans; Kinetics; Molecular Sequence Data; nef Gene Products, Human Immunodeficiency Virus; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Sequence Deletion; Tyrosine | 1995 |
Analysis of phosphorylhydroxyamino acids present in hydrolyzed cell extracts using dabsyl derivatization.
Topics: Cell Extracts; Chromatography, Thin Layer; Electrophoresis; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; p-Dimethylaminoazobenzene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Protein-Tyrosine Kinases; Quercetin; Tumor Cells, Cultured; Tyrosine | 1995 |
Activation of a signal transduction pathway by osteopontin.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Mice; Molecular Sequence Data; Oligopeptides; Osteopontin; Phosphorylation; Phosphotyrosine; Receptors, Cytoadhesin; Sialoglycoproteins; Signal Transduction; Tyrosine | 1995 |
Gene expression and phosphorylation of mouse osteopontin.
Topics: Animals; Base Sequence; Cell Adhesion; DNA Primers; Gene Expression Regulation, Developmental; Mice; Molecular Sequence Data; Osteopontin; Phosphoproteins; Phosphorylation; Phosphotyrosine; RNA, Messenger; Sialoglycoproteins; Tyrosine | 1995 |
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.
Topics: Amino Acid Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Crystallization; Crystallography, X-Ray; Enzyme Activation; Glutamic Acid; Glycine; Mitogen-Activated Protein Kinase 1; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Serine-Threonine Kinases; Structure-Activity Relationship; Tyrosine | 1995 |
Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta.
Topics: Blotting, Western; Cell Membrane; Cell Nucleus; Choriocarcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; Immunosorbent Techniques; Microscopy, Immunoelectron; Nuclear Envelope; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Receptors, LH; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1995 |
Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells.
Topics: Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Epinephrine; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Secretion; Insulin-Like Growth Factor I; Islets of Langerhans; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Potassium Chloride; Receptor, Insulin; Tyrosine | 1995 |
Insulin stimulates the tyrosine phosphorylation of caveolin.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Blotting, Western; Caveolin 1; Caveolins; Epidermal Growth Factor; Insulin; Kinetics; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Polyethylene Glycols; Protein Binding; Protein-Tyrosine Kinases; Tyrosine | 1995 |
ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.
Topics: Amino Acid Sequence; Animals; Avian Proteins; Cerebellum; Chick Embryo; Extracellular Matrix; Heparin; Molecular Sequence Data; Nerve Tissue Proteins; Neuregulin-1; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Receptors, Nicotinic; Recombinant Proteins; Spinal Cord; Synapses; Tyrosine | 1995 |
NGF-stimulated retrograde transport of trkA in the mammalian nervous system.
Topics: Animals; Biological Transport; Blotting, Western; Brain; Ganglia, Sensory; Ganglia, Spinal; Gene Expression; Male; Nerve Growth Factors; Peripheral Nervous System; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, trkA; RNA, Messenger; Tyrosine | 1995 |
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA Mutational Analysis; Immunoblotting; Isoenzymes; Models, Biological; Mutagenesis, Site-Directed; Neurons; PC12 Cells; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins pp60(c-src); Rats; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Type C Phospholipases; Tyrosine | 1995 |
Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.
Topics: Binding Sites; Computer Graphics; Crystallography, X-Ray; ErbB Receptors; Hydrogen Bonding; Models, Molecular; Oligopeptides; Phosphotyrosine; Protein Conformation; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Tyrosine | 1995 |
Tyrosine phosphorylation of vav protooncogene product in primary human myelogenous leukemic cells stimulated by granulocyte colony-stimulating factor.
Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell Cycle Proteins; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1995 |
The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Databases, Factual; Humans; Mice; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tyrosine | 1995 |
Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein.
Topics: 3T3 Cells; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1995 |
Anti-CD9 monoclonal antibody activates p72syk in human platelets.
Topics: Antibodies, Monoclonal; Antigens, CD; Aspirin; Blood Platelets; Enzyme Precursors; Epoprostenol; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Syk Kinase; Tetraspanin 29; Tyrosine | 1995 |
Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Differentiation; Glutathione Transferase; Kinetics; Molecular Sequence Data; Nerve Growth Factors; Neurons; PC12 Cells; Phosphopeptides; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1995 |
Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Line, Transformed; Cells, Cultured; Collagen; Crk-Associated Substrate Protein; Cytochalasin D; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Glycoproteins; Humans; Integrins; Kinetics; Laminin; Molecular Weight; Oncogene Protein pp60(v-src); Oncogene Protein v-crk; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Rats; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Skin; Tyrosine; Vitronectin | 1995 |
Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase.
Topics: Animals; Antibodies; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cytosol; Enzyme Activation; Flow Cytometry; Humans; Immunoblotting; In Vitro Techniques; L-Selectin; Membrane Glycoproteins; Mice; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Fc; Signal Transduction; Superoxides; Tyrosine | 1995 |
Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Division; GRB2 Adaptor Protein; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proteins; Receptor, IGF Type 1; Tyrosine | 1995 |
Increased adherence of Escherichia coli RDEC-1 to human tissue culture cells results in the activation of host signaling pathways.
Topics: Actinin; Animals; Bacterial Adhesion; Carcinoma, Squamous Cell; Cell Line; Cell Line, Transformed; Diarrhea; Epithelium; Escherichia coli; Escherichia coli Infections; Fluorescent Antibody Technique; Humans; Intestines; Phosphotyrosine; Plasmids; Rabbits; Signal Transduction; Species Specificity; Tumor Cells, Cultured; Tyrosine | 1995 |
Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes.
Topics: Anthralin; Cell Line; Cyclosporine; Humans; Immunohistochemistry; Indoles; Intracellular Fluid; Keratinocytes; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Psoriasis; Signal Transduction; Skin; Tacrolimus; Tyrosine | 1995 |
Identification and evaluation of the role of endogenous tyrosine kinases in azoxymethane induction of proliferative processes in the colonic mucosa of rats.
Topics: Animals; Azoxymethane; Bromodeoxyuridine; Catechols; Cell Division; Colon; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; ErbB Receptors; Immunosorbent Techniques; Intestinal Mucosa; Kinetics; Molecular Weight; Nitriles; Ornithine Decarboxylase; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Transforming Growth Factor alpha; Tyrosine; Tyrphostins | 1995 |
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.
Topics: Animals; Cell Adhesion; Cell Line, Transformed; Cell Size; Chickens; CSK Tyrosine-Protein Kinase; Fibroblasts; Fibronectins; Mice; Mice, Knockout; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Subcellular Fractions; Tyrosine | 1995 |
Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Electrophoresis, Polyacrylamide Gel; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Lymphokines; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Prolactin; Recombinant Proteins; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1995 |
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
Topics: Animals; Base Sequence; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; DNA-Binding Proteins; Growth Inhibitors; Interferon-gamma; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization.
Topics: Amino Acid Sequence; Animals; c-Mer Tyrosine Kinase; Egg Proteins; Female; Humans; Male; Membrane Glycoproteins; Mice; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Sperm-Ovum Interactions; Spermatozoa; Tyrosine; Zona Pellucida; Zona Pellucida Glycoproteins | 1995 |
Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction.
Topics: Cell Differentiation; Cell Line; Enzyme Activation; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Globins; Hematopoietic Stem Cells; Interleukin-3; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Recombinant Fusion Proteins; Sequence Deletion; Signal Transduction; Transfection; Tyrosine | 1995 |
Are protein-tyrosine phosphatases specific for phosphotyrosine?
Topics: Animals; Catalysis; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Organophosphates; Phosphates; Phosphorus Isotopes; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Species Specificity; Substrate Specificity; Tyrosine; Water; Yersinia | 1995 |
Calbindin expression in renal tubular epithelial cells. Altered sodium phosphate co-transport in association with cytoskeletal rearrangement.
Topics: Actins; Animals; Base Sequence; Biological Transport; Calbindins; Calcium; Cell Line; Colforsin; Cytoskeleton; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Opossums; Phosphates; Phosphotyrosine; Proteins; Rats; Recombinant Proteins; S100 Calcium Binding Protein G; Sodium; Tetradecanoylphorbol Acetate; Tubulin; Tyrosine | 1995 |
Expression of transmembrane-type protein tyrosine phosphatase mRNA along rat nephron segments.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Blotting, Northern; Blotting, Southern; DNA Primers; Fluorescent Antibody Technique; Gene Expression; Immunohistochemistry; Kidney Cortex; Kidney Medulla; Kidney Tubules; Male; Molecular Sequence Data; Nephrons; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tyrosine | 1995 |
Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides.
Topics: Base Sequence; Cell Division; Cell Line; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphotyrosine; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1995 |
Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C.
Topics: Animals; Antibodies; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Adhesion Molecules; Immunoglobulins; Lectins; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor Aggregation; Sialic Acid Binding Ig-like Lectin 2; Signal Transduction; Spleen; Tyrosine | 1995 |
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.
Topics: beta Catenin; Breast; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Delta Catenin; Epithelial Cells; Epithelium; Female; Genes, ras; Humans; Intercellular Junctions; Phosphoproteins; Phosphorylation; Phosphotyrosine; Solubility; Trans-Activators; Tyrosine | 1995 |
Adhesion-induced tyrosine phosphorylation of the p130 src substrate.
Topics: Animals; Antibodies, Monoclonal; Avian Sarcoma Viruses; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Microscopy, Fluorescence; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Tyrosine | 1995 |
Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.
Topics: Actins; Blotting, Western; Carcinoma, Squamous Cell; Cell Line; Cytochalasin D; Epidermal Growth Factor; Humans; Intercellular Junctions; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine; Zonula Occludens-1 Protein | 1995 |
Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera.
Topics: Humans; Leukocytes, Mononuclear; Molecular Weight; Phosphotyrosine; Polycythemia Vera; Receptor, IGF Type 1; Tyrosine | 1995 |
The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and -independent signaling pathways in T cells.
Topics: Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; CD59 Antigens; Cells, Cultured; Glycosylphosphatidylinositols; Humans; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Glycoproteins; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Thymus Gland; Time Factors; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1995 |
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction.
Topics: Amino Acid Sequence; Base Sequence; Cell Division; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Interleukin-5; Janus Kinase 2; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Growth Factor; Receptors, Interleukin; Receptors, Interleukin-5; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1995 |
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Binding, Competitive; DNA Mutational Analysis; ErbB Receptors; GRB2 Adaptor Protein; Models, Biological; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Tyrosine | 1995 |
Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.
Topics: Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, src; Immunoblotting; Mammary Neoplasms, Animal; Mice; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Differential regulation of the activity of the 42 kD mitogen activated protein kinase (p42mapk) during enterocyte differentiation in vivo.
Topics: Animals; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Chickens; Chromatography; Intestine, Small; Mitogen-Activated Protein Kinase 1; Mitosis; Myelin Basic Protein; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Rabbits; Rats; Sepharose; Substrate Specificity; Tyrosine | 1995 |
Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells.
Topics: Annexin A2; Carcinoma, Hepatocellular; Cell Division; Cell Line; DNA Replication; Ethanol; Gene Expression Regulation, Enzymologic; Humans; Insulin Receptor Substrate Proteins; Liver Neoplasms; Phosphoproteins; Phosphorylation; Phosphotyrosine; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Immunosorbent Techniques; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tyrosine | 1995 |
The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation.
Topics: Animals; Blood Platelets; Horses; Kinetics; Nitriles; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Aggregation; Protein-Tyrosine Kinases; Thrombin; Tyrosine | 1995 |
Inhibition of tumor necrosis factor alpha- and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells.
Topics: Apoptosis; Benzoquinones; Ceramides; DNA; Humans; Lactams, Macrocyclic; Nucleosomes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Second Messenger Systems; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Studies into the identity of the sites of insulin-stimulated insulin receptor serine phosphorylation. Characterization of synthetic peptide substrates for the insulin-stimulated insulin receptor serine kinase.
Topics: Amino Acid Sequence; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Insulin; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptor, Insulin; Serine; Substrate Specificity; Trypsin; Tyrosine | 1995 |
Nuclear multicatalytic proteinase alpha subunit RRC3: differential size, tyrosine phosphorylation, and susceptibility to antisense oligonucleotide treatment.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cell Line, Transformed; Cell Nucleus; Conserved Sequence; Cysteine Endopeptidases; Cytoplasm; DNA Primers; Flow Cytometry; Genes, ras; Immunoblotting; Immunohistochemistry; Kinetics; Liver; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Oligonucleotides, Antisense; Peptides; Phosphotyrosine; Polymerase Chain Reaction; Proteasome Endopeptidase Complex; Rats; Recombinant Proteins; Time Factors; Tyrosine | 1995 |
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Line, Transformed; Conserved Sequence; ErbB Receptors; Genes, src; Glutathione Transferase; Humans; Mice; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proteins; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1995 |
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Conserved Sequence; DNA-Binding Proteins; Gene Expression Regulation; Humans; Luciferases; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphotyrosine; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine | 1995 |
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Recombinant Fusion Proteins; Substrate Specificity; Tyrosine | 1995 |
pp125FAK in human melanocytes and melanoma: expression and phosphorylation.
Topics: Antibodies; Blotting, Western; Cell Adhesion Molecules; Cell Line; Electrophoresis, Polyacrylamide Gel; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Integrin beta1; Integrins; Macromolecular Substances; Melanocytes; Melanoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine | 1995 |
Alterations of the cytoskeletal organization in tumor cell lines by a cardiotonic drug, vesnarinone, through protein tyrosine phosphorylation.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cardiotonic Agents; Catechols; Cell Communication; Cell Line; Cell Line, Transformed; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Genes, src; Humans; Immunoblotting; Lung Neoplasms; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tubulin; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vimentin | 1995 |
Tyrosine phosphorylation of p34cdc2 is regulated by protein phosphatase 2A in growing immature Xenopus oocytes.
Topics: Animals; CDC2 Protein Kinase; Cyclins; Enzyme Activation; Ethers, Cyclic; Female; Homeostasis; Humans; Microinjections; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphotyrosine; Protamine Kinase; Protein Binding; Protein Phosphatase 2; Tyrosine; Xenopus laevis | 1995 |
Amiloride suppresses erythropoietin-induced proliferation and MAP kinase, but potentiates differentiation of J2E cells.
Topics: Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Erythrocytes; Erythropoietin; Genistein; Hemoglobins; Humans; Immunoblotting; Isoflavones; Kinetics; Leucine; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Thymidine; Tyrosine | 1995 |
The activation state of the integrin alpha IIb beta 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Movement; Fibrinogen; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Phosphorylation; Phosphotyrosine; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1995 |
Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine.
Topics: Amino Acid Sequence; Antigens, Viral, Tumor; Binding Sites; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Phosphotyrosine; Polyomavirus; Protein Binding; Protein Structure, Secondary; Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tyrosine | 1995 |
Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes.
Topics: Child, Preschool; Humans; Infant; Infant, Newborn; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, IGF Type 1; Signal Transduction; T-Lymphocytes; Thymus Gland; Tyrosine | 1995 |
Effects of growth factors on phosphatidylinositol-3 kinase in astroglial cells.
Topics: Animals; Astrocytes; Epidermal Growth Factor; Growth Substances; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 1995 |
UV activation of receptor tyrosine kinase activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinase 1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Ultraviolet Rays | 1995 |
Agonist and membrane depolarization induced activation of MAP kinase in the swine carotid artery.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Carotid Arteries; Electrophysiology; Enzyme Activation; Histamine; Myelin Proteins; Phosphorylation; Phosphotyrosine; Swine; Tyrosine; Vasoconstriction | 1995 |
The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Cell Survival; Cytokines; DNA-Binding Proteins; Enzyme Activation; Humans; Janus Kinase 1; Janus Kinase 2; Kinetics; Milk Proteins; Molecular Sequence Data; Neoplasm Proteins; Oligodeoxyribonucleotides; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Immunologic; Receptors, Thrombopoietin; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Transfection; TYK2 Kinase; Tyrosine | 1995 |
Integrin-dependent tyrosine phosphorylation in corneal fibroblasts.
Topics: Animals; Cell Adhesion; Cells, Cultured; Corneal Stroma; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix; Fibroblasts; Fibronectins; Fluorescent Dyes; Immunohistochemistry; Integrins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Receptors, Fibronectin; Signal Transduction; Tyrosine | 1995 |
IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.
Topics: Cells, Cultured; DNA-Binding Proteins; Humans; Interleukin-10; Janus Kinase 1; Monocytes; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; T-Lymphocytes; Th2 Cells; Trans-Activators; TYK2 Kinase; Tyrosine | 1995 |
Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus.
Topics: Adult; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Cells, Cultured; DNA Primers; Gene Expression; Genome, Viral; Herpesvirus 4, Human; Humans; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Receptors, Complement 3d; Signal Transduction; Transcription, Genetic; Tyrosine; Viral Matrix Proteins | 1995 |
Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
Topics: Animals; Benzoquinones; Catechols; Cells, Cultured; Female; Genistein; Hepatitis, Viral, Animal; Isoflavones; Kinetics; Lactams, Macrocyclic; Macrophages, Peritoneal; Mice; Murine hepatitis virus; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine; Tyrphostins | 1995 |
Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Bovine papillomavirus 1; Cell Line; DNA Mutational Analysis; Down-Regulation; Frameshift Mutation; Kinetics; Mice; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Oncogene Proteins, Viral; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Tyrosine | 1995 |
Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; DNA; DNA-Binding Proteins; Interleukin-2; Mice; Milk Proteins; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Receptors, Interleukin-2; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cell Line; DNA Probes; Estrogen Antagonists; Female; Humans; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein Conformation; Receptors, Estrogen; Tumor Cells, Cultured; Tyrosine | 1995 |
Functional link between phosphorylation state of membrane proteins and morphological changes of human erythrocytes.
Topics: Anion Exchange Protein 1, Erythrocyte; Erythrocyte Membrane; Ethers, Cyclic; Humans; Membrane Proteins; Microscopy, Electron, Scanning; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Spectrin; Tyrosine; Vanadates | 1995 |
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; Emodin; Humans; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1995 |
Signal transduction responses following adhesion of verocytotoxin-producing Escherichia coli.
Topics: Bacterial Adhesion; Bacterial Toxins; Calcium; Cell Line; Enterotoxins; Escherichia coli; Humans; Inositol 1,4,5-Trisphosphate; Phosphorylation; Phosphotyrosine; Shiga Toxin 1; Signal Transduction; Tyrosine | 1995 |
Regulation of NK cells through the 80-kDa TNFR (CD120b).
Topics: Antibodies, Monoclonal; Antigens, CD; Cells, Cultured; Cytotoxicity, Immunologic; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lymphocytes; Phosphoproteins; Phosphotyrosine; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Time-resolved signaling pathways of nerve growth factor diverge downstream of the p140trk receptor activation between chick sympathetic and dorsal root ganglion sensory neurons.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Ganglia, Spinal; Ganglia, Sympathetic; Immunoblotting; Kinetics; Male; Mice; Molecular Weight; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 1995 |
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Gene Expression Regulation; Kinetics; Molecular Sequence Data; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Phosphotyrosine; Rats; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Tyrosine | 1995 |
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.
Topics: Animals; Bone Marrow; Cell Division; Cell Line; Enzyme Activation; Humans; Interleukin-13; Interleukin-3; Interleukin-4; Janus Kinase 1; Janus Kinase 3; Macrophages; Mice; Mice, Inbred BALB C; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Tyrosine | 1995 |
Interleukin 2 signaling involves the phosphorylation of Stat proteins.
Topics: Blotting, Western; DNA-Binding Proteins; Humans; Interferon-alpha; Interleukin-2; Killer Cells, Natural; Milk Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Signal Transduction; STAT4 Transcription Factor; STAT5 Transcription Factor; STAT6 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 1995 |
Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Conserved Sequence; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Structure, Secondary; Proteins; Receptors, Antigen, T-Cell; Recombinant Proteins; Sequence Homology, Amino Acid; Shc Signaling Adaptor Proteins; Solutions; Tyrosine | 1995 |
Interleukin 4 signals through two related pathways.
Topics: Animals; Base Sequence; Cell Line; Cystatin B; Cystatins; Cysteine Proteinase Inhibitors; Genes, myc; Hematopoietic Stem Cells; Humans; Insulin Receptor Substrate Proteins; Interleukin-4; Janus Kinase 3; Molecular Sequence Data; Oligonucleotide Probes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Receptors, Interleukin; Receptors, Interleukin-4; Recombinant Proteins; Signal Transduction; Tyrosine | 1995 |
Free radicals induce reversible membrane-cytoplasm translocation of glyceraldehyde-3-phosphate dehydrogenase in human erythrocytes.
Topics: Amidines; Anion Exchange Protein 1, Erythrocyte; Cytoplasm; Erythrocyte Membrane; Erythrocytes; Free Radicals; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; Kinetics; Peroxides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine | 1995 |
The nuclear estrogen receptor R-II of the goat uterus: distinct possibility that the R-II is the deglycosylated form of the nonactivated estrogen receptor (naER).
Topics: Animals; Antibodies; Cell Nucleus; Chromatography, Affinity; Cytosol; DNA, Single-Stranded; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Glycosylation; Goats; Immunoelectrophoresis; Immunoglobulin G; Kinetics; Molecular Weight; Phosphorylation; Phosphotyrosine; Receptors, Estrogen; RNA Polymerase II; Tyrosine; Uterus | 1995 |
Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Chlorocebus aethiops; DNA Replication; Herpesvirus 1, Human; Humans; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins; Vanadates; Vero Cells; Viral Proteins; Virus Replication | 1995 |
Receptor-activated increases in intracellular calcium and protein tyrosine phosphorylation in vascular smooth muscle cells.
Topics: Animals; Calcium; Cells, Cultured; Dogs; Femoral Artery; Fura-2; Genistein; Isoflavones; Muscle, Smooth, Vascular; Nitriles; Phenylephrine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Tyrosine | 1995 |
Effect of glucagon on insulin receptor substrate-1 (IRS-1) phosphorylation and association with phosphatidylinositol 3-kinase (PI 3-kinase).
Topics: Animals; Glucagon; Insulin; Insulin Receptor Substrate Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Reference Values; Tyrosine | 1995 |
Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3.
Topics: Base Sequence; Binding Sites; Cell Differentiation; Cell Division; Cell Line; Cytokines; DNA-Binding Proteins; Enzyme Activation; Humans; Janus Kinase 2; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1995 |
Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium.
Topics: Adenosine Triphosphate; Bacterial Proteins; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Bacterial; Magnetic Resonance Spectroscopy; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Kinases; Protein-Tyrosine Kinases; Salmonella typhimurium; Tyrosine | 1995 |
Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury.
Topics: Animals; Calcineurin; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Fluorescent Dyes; Immunohistochemistry; Male; Microglia; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Reperfusion Injury; Second Messenger Systems; Substantia Nigra; Tyrosine | 1995 |
Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits.
Topics: Animals; Antibody Specificity; In Vitro Techniques; Male; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Tyrosine | 1995 |
T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Membrane; Cricetinae; GRB2 Adaptor Protein; Humans; Isoenzymes; Kinetics; Lymphocyte Activation; Mice; Molecular Sequence Data; Molecular Weight; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Conformation; Proteins; Recombinant Fusion Proteins; T-Lymphocytes; Transfection; Type C Phospholipases; Tyrosine | 1995 |
PC12-E2 cells: a stable variant with altered responses to growth factor stimulation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Growth Substances; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurites; PC12 Cells; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Transcription, Genetic; Tyrosine | 1995 |
Synergistic interaction of interleukin-1 beta and growth factors in primary cultures of rat aortic smooth muscle cells.
Topics: Animals; Cell Division; Cells, Cultured; Cyclic GMP; DNA; Drug Synergism; Fibroblast Growth Factor 2; Gene Expression; Genes, fos; In Vitro Techniques; Interleukin-1; Interleukin-6; Male; Mitogens; Muscle, Smooth, Vascular; Nitric Oxide; Phosphotyrosine; Platelet-Derived Growth Factor; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; RNA, Messenger; Tyrosine | 1995 |
Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa.
Topics: 3T3 Cells; Animals; Blotting, Western; Calcium; Cell Differentiation; Cell Line; Cell Line, Transformed; Clone Cells; Fibroblasts; GTPase-Activating Proteins; Humans; Keratinocytes; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rats; Recombinant Proteins; Tyrosine | 1995 |
Ligand-dependent and -independent activation of the transcription factor gamma RF-1 in a cell-free system.
Topics: Adenosine Triphosphate; Antibodies; Base Sequence; Carcinoma, Squamous Cell; Cell Line; Cell-Free System; Cytosol; Humans; Interferon-gamma; Kinetics; Leukemia, Myeloid; Ligands; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Repetitive Sequences, Nucleic Acid; Skin Neoplasms; Transcription Factors; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD34; B-Lymphocyte Subsets; Biomarkers, Tumor; Blast Crisis; Bone Marrow; Cell Line; Cell Separation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
A 69-kDa membrane protein associated with lipopolysaccharide (LPS)-induced signal transduction in the human monocytic cell line THP-1.
Topics: Blotting, Western; Cell Line; Humans; Immunologic Techniques; Lipopolysaccharides; Membrane Proteins; Molecular Weight; Monocytes; Phosphotyrosine; Receptors, Immunologic; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Kinetics of tyrosine phosphorylation when IgE dimers bind to FC epsilon receptors on rat basophilic leukemia cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Immunoglobulin E; Leukemia, Basophilic, Acute; Macromolecular Substances; Mathematics; Mice; Models, Structural; Models, Theoretical; Phosphorylation; Phosphotyrosine; Rabbits; Rats; Receptors, IgE; Tumor Cells, Cultured; Tyrosine | 1995 |
Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.
Topics: Animals; Cell Line; Chlorocebus aethiops; Insulin Receptor Substrate Proteins; Interleukin-4; Interleukin-9; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Recombinant Proteins; T-Lymphocytes; Transfection; TYK2 Kinase; Tyrosine | 1995 |
Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway.
Topics: Animals; Antibodies; Antibody Specificity; Cell Line; Immunoblotting; Immunoglobulin G; Insulin; Kinetics; Liver Neoplasms, Experimental; Phosphotyrosine; Protein Tyrosine Phosphatases; Rabbits; Rats; Receptor, Insulin; Tyrosine | 1995 |
Identification of Lck-binding elements in tip of herpesvirus saimiri.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Chlorocebus aethiops; DNA Primers; Herpesvirus 2, Saimiriine; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Spodoptera; Structure-Activity Relationship; Transfection; Tyrosine; Viral Proteins | 1995 |
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Isoenzymes; Kinetics; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Receptor, Insulin; Recombinant Proteins; Substrate Specificity; Transfection; Tyrosine | 1995 |
Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function.
Topics: Acrosome; Calcimycin; Catalase; Egg Proteins; Exocytosis; Female; Humans; Male; Membrane Fusion; Membrane Glycoproteins; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Reactive Oxygen Species; Receptors, Cell Surface; Sperm-Ovum Interactions; Spermatozoa; Sulfhydryl Reagents; Superoxide Dismutase; Tyrosine; Zona Pellucida Glycoproteins | 1995 |
Dexamethasone enhances insulin-like growth factor-I effects on skeletal muscle cell proliferation. Role of specific intracellular signaling pathways.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Dexamethasone; DNA; Drug Synergism; Gene Expression; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins c-fos; Rats; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Signal Transduction; Tyrosine | 1995 |
The effects of N-ras oncogene expression on PDGF-BB stimulated responses in cultured mouse myoblasts.
Topics: Animals; Becaplermin; Bradykinin; Calcium; Cell Line; Dexamethasone; Gene Expression; Gene Expression Regulation; Genes, ras; Ionomycin; Kinetics; Mice; Molecular Weight; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Proto-Oncogene Proteins p21(ras); Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Tyrosine | 1995 |
Interleukin-11 induces phosphatidic acid formation and activates MAP kinase in mouse 3T3-L1 cells.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Glycerophospholipids; Humans; Immunoblotting; Interleukin-11; Interleukin-6; Mice; Phosphatidic Acids; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Tyrosine | 1995 |
Signalling an interest.
Topics: Amino Acid Sequence; Animals; Consensus Sequence; Humans; Models, Molecular; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptors, Cell Surface; Sequence Alignment; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1994 |
Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Fusion Proteins, bcr-abl; Glutathione Transferase; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Weight; Nuclear Proteins; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tumor Cells, Cultured; Tyrosine | 1995 |
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Division; CHO Cells; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Enzyme Activation; Growth Hormone; Humans; Janus Kinase 2; Mutagenesis, Site-Directed; Phenylalanine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Recombinant Proteins; Sequence Deletion; Transfection; Tyrosine | 1995 |
Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Calcimycin; Calcium; Cell Line; Cloning, Molecular; Cytosol; DNA Primers; Gene Expression; Immunoblotting; Intracellular Signaling Peptides and Proteins; Leukemia, Basophilic, Acute; Mice; Molecular Sequence Data; Organ Specificity; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Receptors, IgE; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Flow cytometric analysis of protein-tyrosine phosphorylation in peripheral T cell subsets. Application to healthy and HIV-seropositive subjects.
Topics: CD3 Complex; Flow Cytometry; HIV Seropositivity; Humans; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; T-Lymphocyte Subsets; Tyrosine | 1995 |
Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.
Topics: Acute-Phase Proteins; Amino Acid Sequence; Animals; Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cloning, Molecular; Cytokine Receptor gp130; DNA-Binding Proteins; Gene Expression; Genes; Humans; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Interleukin-6; Macrophages; Membrane Glycoproteins; Mice; Mice, Knockout; Molecular Sequence Data; NF-kappa B; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
Interleukin (IL)-11--mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; Cytokine Receptor gp130; Gene Expression Regulation; Interleukin-11; Isoquinolines; Janus Kinase 1; Janus Kinase 2; Membrane Glycoproteins; Mice; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Ribosomal Protein S6 Kinases; RNA, Messenger; Second Messenger Systems; Signal Transduction; Transcription Factors; Tyrosine | 1995 |
Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Antigens, CD; Base Sequence; Cloning, Molecular; Cytokine Receptor gp130; DNA-Binding Proteins; Genes, jun; Humans; Isoquinolines; Janus Kinase 1; Janus Kinase 2; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); Receptors, Interleukin; Receptors, Interleukin-6; Signal Transduction; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
Uncoupling of the proliferation and differentiation signals mediated by the murine macrophage colony-stimulating factor receptor expressed in myeloid FDC-P1 cells.
Topics: Animals; Cell Differentiation; Cell Division; Colforsin; Cyclic AMP; Dinoprostone; Hematopoietic Stem Cells; Macrophage Colony-Stimulating Factor; Mice; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1995 |
Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5.
Topics: Alkaloids; Cell Division; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Interleukin-3; Interleukin-5; Kinetics; Leukemia, Erythroblastic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1.
Topics: Animals; Base Sequence; Cell Division; DNA; Enzyme Activation; Interferon-gamma; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred BALB C; Mitogens; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Critical role for the phosphorylation of tyrosines 674 and 675 in signalling by the Trk tyrosine kinase.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Line; Chlorocebus aethiops; CHO Cells; Cricetinae; Mutagenesis, Site-Directed; Nerve Growth Factors; Nerve Tissue Proteins; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Point Mutation; Rats; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; Recombinant Proteins; Signal Transduction; Transcription, Genetic; Transfection; Tyrosine | 1995 |
Construction and expression of a functional chimeric receptor from PDGFr-beta and c-erbB-2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Genetic Vectors; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Polymerase Chain Reaction; Receptor, ErbB-2; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Restriction Mapping; Transfection; Tyrosine | 1995 |
Differential effects of wortmannin on growth hormone dependent signalling pathways in 3T3-F442A cells.
Topics: 3T3 Cells; Androstadienes; Animals; Culture Media, Serum-Free; Growth Hormone; Insulin Antagonists; Kinetics; Mice; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine; Wortmannin | 1995 |
The mitogen-activated protein kinase cascade in rat islets of Langerhans.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ethers, Cyclic; Glucose; Islets of Langerhans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.
Topics: Androstadienes; Animals; CD28 Antigens; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Lymphocyte Activation; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase by protein kinase C and protein kinase A in EAhy926 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Indoles; Isoenzymes; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Identification of a variable region within the cytoplasmic tail of the IL-2 receptor beta chain that is required for growth signal transduction.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; DNA-Binding Proteins; In Vitro Techniques; Interleukin-2; Janus Kinase 1; Janus Kinase 3; Mice; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Interleukin-2; Signal Transduction; STAT5 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Tyrosine | 1995 |
Identification of a putative Syp substrate, the PDGF beta receptor.
Topics: Amino Acid Sequence; Base Sequence; DNA Primers; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1995 |
Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Cells, Cultured; Cortactin; Crk-Associated Substrate Protein; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; In Vitro Techniques; Integrins; Mice; Microfilament Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rats; Retinoblastoma-Like Protein p130; Tyrosine | 1995 |
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; In Vitro Techniques; Interleukin-3; Isoquinolines; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-3; Signal Transduction; Staurosporine; Tyrosine | 1995 |
Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
Topics: Amino Acid Sequence; Animals; Cell Compartmentation; Cell Nucleus; Cells, Cultured; Cytosol; DNA-Binding Proteins; Humans; Immunologic Techniques; In Vitro Techniques; Ionomycin; Lymphocyte Activation; Mice; Molecular Sequence Data; NFATC Transcription Factors; Nuclear Proteins; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; T-Lymphocytes; Tacrolimus; Transcription Factors; Tyrosine | 1995 |
Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.
Topics: Agammaglobulinaemia Tyrosine Kinase; Amino Acid Sequence; Antigens, CD; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Cells, Cultured; Cytoplasm; DNA Primers; Enzyme Precursors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Sequence Deletion; src-Family Kinases; Syk Kinase; T-Lymphocytes; Transfection; Tyrosine | 1995 |
Inhibition by 5'-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas.
Topics: Antibodies; Cell Division; Cell Line; Cell Nucleus; Cross-Linking Reagents; Deoxyadenosines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factor 2; Glioblastoma; Glioma; Humans; Immunoblotting; Iodine Radioisotopes; Methyltransferases; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Thionucleosides; Tyrosine | 1995 |
TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line.
Topics: Animals; Cell Cycle Proteins; Cell Line; Enzyme Induction; Hematopoietic Stem Cells; Humans; Interleukin-3; Janus Kinase 1; Janus Kinase 2; Mice; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Receptors, Cytokine; Receptors, Immunologic; Receptors, Thrombopoietin; Recombinant Proteins; Thrombopoietin; Transfection; Tyrosine | 1995 |
Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition.
Topics: Animals; Antigens; Cell Line; Cell Membrane; Immunoglobulin E; Isoenzymes; Kinetics; Leukemia, Basophilic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Receptors, IgE; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart.
Topics: Angiotensin II; Animals; Electrophoresis, Polyacrylamide Gel; Immunoblotting; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Male; Molecular Weight; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Tyrosine | 1995 |
Adhesion-inducible DNA synthesis regulated by tyrosine phosphorylation/dephosphorylation.
Topics: Animals; Benzoquinones; Cell Adhesion; Cell Line; DNA; Enzyme Inhibitors; Epithelium; Fibronectins; Lactams, Macrocyclic; Liver; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Tyrosine; Vanadates | 1995 |
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
Topics: Amino Acid Sequence; Animals; Cell Line; Isoenzymes; Leukemia, Basophilic, Acute; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Receptors, IgE; src-Family Kinases; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1995 |
Fibroblast spreading and proliferation on hydrophilic and hydrophobic surfaces is related to tyrosine phosphorylation in focal contacts.
Topics: Adsorption; Biocompatible Materials; Cell Adhesion; Cell Division; Fibroblasts; Fibronectins; Glass; Humans; Immunoenzyme Techniques; Microscopy, Fluorescence; Phosphorylation; Phosphotyrosine; Silicon Dioxide; Surface Properties; Tyrosine | 1995 |
The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells.
Topics: Animals; Basophils; Cinnamates; Dinitrophenols; Haptens; Histamine Release; Immunoblotting; Immunoglobulin E; Immunosuppressive Agents; Leukemia, Basophilic, Acute; Naphthalenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Serum Albumin; Signal Transduction; Sulfides; Time Factors; Tumor Cells, Cultured; Tyrosine | 1995 |
Autophosphorylation of purified c-Src at its primary negative regulation site.
Topics: Escherichia coli; Mutation; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Tyrosine | 1995 |
Tyrosine phosphorylation and acetylcholine receptor cluster formation in cultured Xenopus muscle cells.
Topics: Animals; Catechols; Cells, Cultured; Fluorescent Antibody Technique; In Vitro Techniques; Muscle Proteins; Muscles; Neuromuscular Junction; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Nicotinic; Tyrosine; Tyrphostins; Xenopus laevis | 1993 |
A role of tyrosine phosphorylation in the formation of acetylcholine receptor clusters induced by electric fields in cultured Xenopus muscle cells.
Topics: Animals; Catechols; Cells, Cultured; Electric Stimulation; In Vitro Techniques; Neuromuscular Junction; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Nicotinic; Signal Transduction; Tyrosine; Tyrphostins; Xenopus laevis | 1993 |
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.
Topics: Animals; Base Sequence; Cells, Cultured; Consensus Sequence; Cytoplasm; Dogs; Humans; In Vitro Techniques; Inositol Phosphates; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship; Type C Phospholipases; Tyrosine | 1993 |
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Transformation, Neoplastic; Cloning, Molecular; DNA; Drosophila Proteins; Gene Expression Regulation; Gene Rearrangement; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Thyroid Neoplasms; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation in human cells by activation of the growth hormone receptor.
Topics: Binding Sites; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Growth Hormone; Humans; Insulin; Kinetics; Macromolecular Substances; Molecular Weight; Mutagenesis; Phosphoproteins; Phosphotyrosine; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; Tyrosine | 1993 |
Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Conserved Sequence; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Kinetics; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Recombinant Fusion Proteins; Type C Phospholipases; Tyrosine | 1993 |
Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Mitogens; Molecular Sequence Data; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1993 |
Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes.
Topics: Actins; Animals; Cell Adhesion; Cell Membrane; Dictyostelium; Immunoblotting; Immunosorbent Techniques; Kinetics; Phosphotyrosine; Tyrosine | 1993 |
Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins.
Topics: Animals; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Dimethyl Sulfoxide; Mice; Neoplasm Proteins; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Tyrosine | 1993 |
O-phospho-L-tyrosine inhibits cellular growth by activating protein tyrosine phosphatases.
Topics: Breast Neoplasms; Carcinoma, Renal Cell; Cell Death; Cell Division; Doxorubicin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Etoposide; Humans; Kidney Neoplasms; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine | 1993 |
Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides.
Topics: Amino Acid Sequence; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Phosphotyrosine; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; T-Lymphocytes; Tyrosine | 1993 |
Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.
Topics: Actins; Animals; Female; Fluorescent Antibody Technique; Genistein; In Vitro Techniques; Isoflavones; Macrophages; Mice; Mice, Inbred C57BL; Phagocytosis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fc; Tyrosine | 1993 |
Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine.
Topics: Amino Acid Sequence; Bacteria; Base Sequence; Histidine; Humans; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Substrate Specificity; Threonine; Tyrosine | 1993 |
Activation of a histone H1 kinase by tyrosine phosphorylation in v-src-transformed fibroblasts.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Fibroblasts; Fungal Proteins; Genes, src; Homeostasis; Immunoblotting; Kinetics; Molecular Sequence Data; Phosphotyrosine; Protamine Kinase; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Schizosaccharomyces pombe Proteins; Tyrosine | 1993 |
Cellular and in vivo characterization of the MCR rat mammary tumor model.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Division; ErbB Receptors; Female; Gene Amplification; Gene Expression; Genes, ras; Genes, src; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1993 |
Cell cycle-specific activation of the PTK72 protein-tyrosine kinase in B lymphocytes.
Topics: Animals; B-Lymphocytes; Cell Cycle; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Lymphocyte Activation; Mice; Mitogens; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Tyrosine | 1993 |
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
Topics: 3T3 Cells; Animals; Base Sequence; Cell Cycle; Deoxyglucose; Enzyme Activation; Gene Expression; Immunologic Techniques; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Ornithine Decarboxylase; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Somatomedin; RNA, Messenger; Signal Transduction; Tyrosine | 1993 |
Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.
Topics: Amphiregulin; Antibodies, Monoclonal; Cell Division; Cells, Cultured; EGF Family of Proteins; Epithelium; ErbB Receptors; Glycoproteins; Growth Substances; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Tyrosine | 1993 |
Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Fibroblast Growth Factors; Genetic Vectors; In Vitro Techniques; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Metastasis; Neoplasms, Experimental; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Sorting Signals; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 1993 |
The role of Cys-17 in the pyridoxal 5'-phosphate inhibition of the bovine liver low M(r) phosphotyrosine protein phosphatase.
Topics: Animals; Binding, Competitive; Cattle; Cloning, Molecular; Cysteine; Escherichia coli; Kinetics; Liver; Mutagenesis, Site-Directed; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Schiff Bases; Spectrophotometry, Ultraviolet; Tyrosine | 1993 |
Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Infectious; Arthritis, Rheumatoid; Female; Fibroblast Growth Factor 1; Glucocorticoids; Humans; Immunohistochemistry; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Rats, Inbred F344; Rats, Inbred Lew; Synovial Membrane; Tyrosine | 1993 |
Inhibition of tyrosine phosphorylation prevents IFN-gamma-induced HLA-DR molecule expression.
Topics: Benzoquinones; Calcimycin; Calcium; Genistein; HLA-DR Antigens; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Interferon-gamma; Isoflavones; Lactams, Macrocyclic; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.
Topics: Amino Acid Sequence; Blotting, Western; Cell Compartmentation; Enzyme Activation; ErbB Receptors; Genistein; Humans; Isoflavones; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Tyrosine | 1993 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein.
Topics: Animals; Avian Proteins; Brain; Cell Communication; Cell Membrane; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Membrane Proteins; Molecular Weight; Motor Neurons; Muscles; Nerve Tissue Proteins; Neuregulin-1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptors, Cholinergic; Spinal Cord; Suramin; Tyrosine | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Topics: Breast Neoplasms; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Genistein, a tyrosine kinase inhibitor, blocks the cell cycle progression but not Ca2+ influx induced by BAY K8644 in FRTL-5 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Cell Cycle; DNA; Genistein; Insulin-Like Growth Factor I; Isoflavones; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Thyrotropin; Time Factors; Tyrosine | 1993 |
Tyrosine phosphorylation of phospholipase C gamma in c-met/HGF receptor-stimulated hepatocytes: comparison with HepG2 hepatocarcinoma cells.
Topics: Animals; Cells, Cultured; Hepatocyte Growth Factor; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Liver; Liver Neoplasms, Experimental; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-met; Rats; Receptors, Cell Surface; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1993 |
The chimeric receptor between interleukin-2 receptor beta chain and interleukin-4 receptor transduces interleukin-2 signal.
Topics: Animals; Base Sequence; Cell Division; Cells, Cultured; In Vitro Techniques; Interleukin-2; Interleukin-4; Mice; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Receptors, Interleukin-4; Receptors, Mitogen; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1993 |
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.
Topics: 3T3 Cells; Animals; Brain-Derived Neurotrophic Factor; Enzyme Activation; Humans; Membrane Proteins; Mice; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Ciliary Neurotrophic Factor; Tyrosine | 1993 |
Properties of a purified estradiol-dependent calf uterus tyrosine kinase.
Topics: Actins; Amino Acid Sequence; Animals; Calcium; Calmodulin; Cattle; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Histones; Humans; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Phosphotyrosine; Protein Denaturation; Protein-Tyrosine Kinases; Receptors, Estradiol; Substrate Specificity; Tyrosine; Uterus | 1993 |
Antiserum to carcinoembryonic antigen recognizes a phosphotyrosine-containing protein in human colon cancer cell lines.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Humans; In Vitro Techniques; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Tumor Cells, Cultured; Tyrosine | 1993 |
Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins. Evidence from reactivity to monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Blotting, Western; CDC2 Protein Kinase; Cell Line; Chlorocebus aethiops; Epitopes; Humans; Hybridomas; Mutation; Phosphoproteins; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Protozoan Proteins; Structure-Activity Relationship; Tyrosine | 1993 |
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
Topics: Amino Acid Sequence; Genes, src; Humans; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Recombinant Fusion Proteins; Sequence Homology; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1993 |
In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade.
Topics: Antibodies, Monoclonal; Base Sequence; Cell Nucleus; Cell-Free System; Cells, Cultured; DNA-Binding Proteins; Fibroblasts; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Molecular Sequence Data; Nuclear Proteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Transcription Factors; Tyrosine | 1993 |
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.
Topics: Biological Transport; Cell Compartmentation; Cytoskeleton; Fibrinogen; Humans; Integrins; Octoxynol; Phosphotyrosine; Platelet Activation; Platelet Membrane Glycoproteins; Polyethylene Glycols; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Solubility; Thrombasthenia; Thrombin; Tyrosine | 1993 |
Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor.
Topics: Animals; Antibodies, Monoclonal; Bacterial Proteins; Cell Line; Drosophila; Drosophila Proteins; Eye Proteins; Gene Expression; Kinetics; Ligands; Membrane Glycoproteins; Neurons; Phosphotyrosine; Photoreceptor Cells; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Peptide; Transfection; Tyrosine | 1993 |
Cell-free activation of a DNA-binding protein by epidermal growth factor.
Topics: 3T3 Cells; Animals; Cell Fractionation; Cell Line; Cell Membrane; Cell Nucleus; Cell-Free System; Cytosol; Dithiothreitol; DNA-Binding Proteins; Drosophila melanogaster; Epidermal Growth Factor; Genes, fos; Humans; Mice; Phosphotyrosine; Signal Transduction; Transcription, Genetic; Tyrosine; Ultracentrifugation | 1993 |
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
Topics: Amino Acid Sequence; Binding Sites; Hydrogen Bonding; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Molecular Sequence Data; Oncogene Proteins, Viral; Phosphopeptides; Phosphotyrosine; Protein Structure, Secondary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1993 |
Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.
Topics: Animals; Calcium; Calcium Channels; Carbachol; CHO Cells; Cricetinae; Female; In Vitro Techniques; Ion Channel Gating; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Phosphoproteins; Phosphotyrosine; Rats; Receptors, Muscarinic; Second Messenger Systems; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Effect of orthovanadate on tyrosine phosphorylation of P120 GTPase-activating protein in rat liver macrophages (Kupffer cells).
Topics: Animals; Cells, Cultured; GTPase-Activating Proteins; Kinetics; Kupffer Cells; Phosphorylation; Phosphotyrosine; Proteins; Rats; Subcellular Fractions; Tyrosine; Vanadates | 1993 |
Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes.
Topics: Amino Acid Sequence; CD4 Antigens; CD4-Positive T-Lymphocytes; Enzyme Activation; Gene Products, env; HIV Envelope Protein gp120; HIV Envelope Protein gp160; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Precursors; Protein-Tyrosine Kinases; Signal Transduction; Substrate Specificity; Tyrosine | 1993 |
Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.
Topics: Amino Acid Sequence; Animals; Axons; Chromosome Mapping; Crosses, Genetic; DNA; Drosophila melanogaster; Drosophila Proteins; Female; Gene Library; Genes, abl; Genes, Regulator; Genotype; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Insertional; Nerve Tissue Proteins; Nervous System; Nuclear Proteins; Oncogene Proteins v-abl; Open Reading Frames; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Deletion; Substrate Specificity; Tyrosine | 1993 |
The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.
Topics: 3T3 Cells; Adipose Tissue; Animals; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Tyrosine | 1993 |
Immunohistochemistry of phosphotyrosine residues: identification of distinct intracellular patterns in epithelial and steroidogenic tissues.
Topics: Adrenal Glands; Animals; Antibodies, Monoclonal; Brain Chemistry; Endometrium; Epithelium; Female; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Ovary; Phosphotyrosine; Rats; Testis; Tyrosine | 1993 |
Gi alpha and Gi beta are part of a signalling complex in Balb/c3T3 cells: phosphorylation of Gi beta in growth-factor-activated fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Insulin; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1993 |
Changes in tyrosine phosphorylation in neocortex following transient cerebral ischaemia.
Topics: Animals; Blotting, Western; Cerebral Cortex; Cytosol; Electrophoresis, Polyacrylamide Gel; Ischemic Attack, Transient; Kinetics; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Subcellular Fractions; Synaptosomes; Time Factors; Tyrosine | 1993 |
Neurofilament monoclonal antibodies RT97 and 8D8 recognize different modified epitopes in paired helical filament-tau in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Chymotrypsin; Epitopes; Humans; Microscopy, Immunoelectron; Neurofibrillary Tangles; Neurofilament Proteins; Peptide Fragments; Peptide Mapping; Phosphotyrosine; tau Proteins; Trypsin; Tyrosine; Ubiquitins | 1993 |
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.
Topics: Animals; Cell Differentiation; Mitogens; Nerve Growth Factors; Neurons; Nuclear Proteins; Oncogene Protein pp60(v-src); Oncogenes; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 1993 |
The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Cyclic AMP; DNA Mutational Analysis; GTP-Binding Proteins; In Vitro Techniques; Mice; Myristic Acid; Myristic Acids; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); Receptors, Adrenergic, beta; Signal Transduction; Structure-Activity Relationship; Transfection; Tyrosine | 1993 |
Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cell Membrane; fms-Like Tyrosine Kinase 3; Glycoproteins; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Peptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Sequence Alignment; Tyrosine | 1993 |
Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.
Topics: Animals; Cell Line; DNA; DNA-Binding Proteins; Gene Expression; Genes, src; Growth Substances; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; In Vitro Techniques; Mice; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; ras-GRF1; Repressor Proteins; RNA-Binding Proteins; Tyrosine | 1993 |
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
Topics: Amino Acid Sequence; Animals; Cell Line; Chimera; Drosophila; Enzyme Activation; ErbB Receptors; Genes, src; Humans; Kidney; Luminescent Measurements; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Plasmids; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Receptor, ErbB-2; Receptors, Platelet-Derived Growth Factor; Sequence Homology, Amino Acid; Signal Transduction; Transfection; Tyrosine | 1993 |
Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.
Topics: Animals; Cell Differentiation; Cell Division; Cell Membrane; Ciliary Neurotrophic Factor; Cloning, Molecular; Gene Expression; Glycosylphosphatidylinositols; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Muscle Denervation; Muscles; Nerve Tissue Proteins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphotyrosine; Rats; Receptor, Ciliary Neurotrophic Factor; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
An osmosensing signal transduction pathway in yeast.
Topics: Amino Acid Sequence; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Genes, Fungal; Molecular Sequence Data; Osmolar Concentration; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinases; Restriction Mapping; Saccharomyces cerevisiae; Signal Transduction; Tyrosine; Water-Electrolyte Balance | 1993 |
Evidence for involvement of phospholipase C-gamma 2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cells, Cultured; Gene Expression; Immunosorbent Techniques; Macromolecular Substances; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rabbits; RNA; Signal Transduction; Type C Phospholipases; Tyrosine | 1993 |
Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer.
Topics: Animals; Baculoviridae; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Escherichia coli; Fungal Proteins; Moths; Nuclear Proteins; Peptides; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Tyrosine | 1993 |
Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; Calcium; CD79 Antigens; CD8 Antigens; Cytoplasm; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation without inositol lipid hydrolysis in human B lymphocytes on engaging CD72.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Calcium; Cells, Cultured; Humans; In Vitro Techniques; Inositol Phosphates; Molecular Weight; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Signal Transduction; Tyrosine | 1993 |
The induction of early response genes in rat smooth muscle cells by PDGF-AA is not sufficient to stimulate DNA-synthesis.
Topics: Animals; Cells, Cultured; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Gene Expression; Genes, fos; Genes, myc; Immediate-Early Proteins; In Vitro Techniques; Muscle, Smooth, Vascular; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Rats, Inbred WKY; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Transcription Factors; Tyrosine | 1993 |
Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; CD8 Antigens; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Macromolecular Substances; Membrane Proteins; Mice; Mice, Inbred C57BL; Oligosaccharides; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 1993 |
Atrial natriuretic factor stimulates phosphorylation of a 52-kDa calmodulin-binding protein in vascular smooth muscle cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Calmodulin-Binding Proteins; Cells, Cultured; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Endothelins; Male; Muscle, Smooth, Vascular; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Rats, Wistar; Tyrosine | 1993 |
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.
Topics: Animals; Animals, Newborn; Carrier Proteins; Cell Membrane; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Kinetics; Liver; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Tyrosine | 1993 |
A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Blotting, Western; Cyanobacteria; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial; Molecular Sequence Data; Multigene Family; Open Reading Frames; Phosphotyrosine; Protein Tyrosine Phosphatases; Restriction Mapping; Sequence Homology, Amino Acid; Tyrosine | 1993 |
Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbachol; CHO Cells; Cricetinae; Isoenzymes; Kinetics; Marine Toxins; Oxocins; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Receptors, Muscarinic; Transfection; Type C Phospholipases; Tyrosine | 1993 |
Identification of p125, a component of a group of 120-kDa proteins that are phosphorylated on tyrosine residues in response to bradykinin and bombesin stimulation, in anti-ras-GTPase-activating protein immunoprecipitates of Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Antibodies; Bombesin; Bradykinin; Cell Division; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; GTPase-Activating Proteins; Humans; Immunoblotting; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Tyrosine | 1993 |
Phosphorylation of recombinant non-NMDA glutamate receptors on serine and tyrosine residues.
Topics: Cell Line; Embryo, Mammalian; Gene Expression; Humans; Immunosorbent Techniques; Kidney; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Glutamate; Recombinant Proteins; Transfection; Tyrosine | 1993 |
Protein kinases in divergent eukaryotes: identification of protein kinase activities regulated during trypanosome development.
Topics: Animals; Epidermal Growth Factor; Giardia lamblia; Humans; Isoenzymes; Kinetics; Phosphotyrosine; Protein Denaturation; Protein Kinases; Species Specificity; Trichomonas vaginalis; Trypanosoma brucei brucei; Tumor Cells, Cultured; Tyrosine | 1993 |
In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.
Topics: Humans; In Vitro Techniques; Isoenzymes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1993 |
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Topics: Breast Neoplasms; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Involvement of tyrosine phosphorylation in IgE receptor-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells.
Topics: Animals; Antigens; Basophils; Cinnamates; Enzyme Activation; Genistein; Immunoglobulin E; In Vitro Techniques; Isoflavones; Leukemia, Basophilic, Acute; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Signal Transduction; Sulfides; Tumor Cells, Cultured; Tyrosine | 1993 |
c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.
Topics: Amino Acid Sequence; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; Tyrosine | 1993 |
The human granulocyte-macrophage colony-stimulating factor receptor is capable of initiating signal transduction in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Cycle; Gene Expression; Genes, fos; Genes, myc; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Mice; Phosphoproteins; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; Signal Transduction; Transfection; Tyrosine | 1993 |
Tyrosine phosphate in a- and b-type flagellins of Pseudomonas aeruginosa.
Topics: Antibodies, Monoclonal; Flagella; Flagellin; Immunoblotting; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Pseudomonas aeruginosa; Trypsin; Tyrosine | 1993 |
Requirement for both H and L chain V regions, VH and VK joining amino acids, and the unique H chain D region for the high affinity binding of an anti-phosphotyrosine antibody.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites, Antibody; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Molecular Sequence Data; Phosphotyrosine; Structure-Activity Relationship; Tyrosine | 1993 |
Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Ion Exchange; Ethers, Cyclic; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Isoflavones; Neutrophils; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1993 |
Phosphotyrosine-modified proteins are localized in Müller cells of the chick neural retina.
Topics: Animals; Cell Membrane; Chickens; Cytoplasm; Eye Proteins; Microscopy, Immunoelectron; Molecular Weight; Neuroglia; Phosphotyrosine; Protein-Tyrosine Kinases; Retina; Tyrosine | 1993 |
Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.
Topics: Animals; Blotting, Northern; Dose-Response Relationship, Drug; Enzyme Activation; Genes, myc; Genistein; Humans; Interleukin-2; Isoflavones; Kinetics; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Mice; Mice, Inbred C57BL; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; RNA, Messenger; RNA, Ribosomal, 18S; T-Lymphocytes; Thymidine; Tyrosine | 1993 |
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Enzyme Activation; Genes, abl; Humans; Mice; Moloney murine sarcoma virus; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Rats; Restriction Mapping; Signal Transduction; Transfection; Tyrosine | 1993 |
Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antibodies; Antibodies, Monoclonal; B-Lymphocytes; Blood Proteins; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Leukocyte Common Antigens; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases.
Topics: 4-Nitrophenylphosphatase; Acid Phosphatase; Adipose Tissue; Amino Acid Sequence; Animals; Brain; Chromatography, High Pressure Liquid; Glutathione Transferase; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Recombinant Fusion Proteins; Substrate Specificity; Tyrosine | 1993 |
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.
Topics: DNA; DNA Mutational Analysis; Enzyme Activation; GTPase-Activating Proteins; Humans; In Vitro Techniques; Mitosis; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1993 |
Induction of early gene expression in murine macrophages by synthetic lipid A analogs with differing endotoxic potentials.
Topics: Animals; Carbohydrate Sequence; Endotoxins; Female; Gene Expression; Glycolipids; In Vitro Techniques; Interleukin-1; Lipid A; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C3H; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase.
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, fms; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; T-Lymphocytes; Transfection; Tyrosine | 1993 |
Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells.
Topics: Animals; Blotting, Western; Bronchi; Cell Division; Cell Line; Epidermal Growth Factor; Epithelium; Gene Expression; Humans; In Vitro Techniques; Ki-67 Antigen; Ligands; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tyrosine | 1993 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Isolation and culture of retinal microglia.
Topics: Animals; Cell Division; Cell Separation; Cells, Cultured; Disease Models, Animal; Lectins; Macrophage-1 Antigen; Microscopy, Fluorescence; Neuroglia; Phagocytosis; Phosphotyrosine; Rats; Rats, Mutant Strains; Retina; Retinal Degeneration; Tyrosine; Vimentin | 1993 |
A cytosolic activator of DNA replication is tyrosine phosphorylated in its active form.
Topics: Aprotinin; Cytosol; DNA Replication; Dose-Response Relationship, Drug; Flavonoids; Genistein; Humans; In Vitro Techniques; Isoflavones; Kaempferols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quercetin; Signal Transduction; Tyrosine | 1993 |
Insulin-induced circular membrane ruffling on rat 1 cells expressing a high number of human insulin receptors: circular ruffles caused by rapid actin reorganization exhibit high density of insulin receptors and phosphotyrosines.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescent Antibody Technique; In Vitro Techniques; Insulin; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptor, Insulin; Time Factors; Transfection; Tyrosine | 1993 |
Immortalization and neoplastic transformation of normal rat colon epithelium: an in vitro model of colonic neoplastic progression.
Topics: Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytological Techniques; Gene Expression; Intestinal Mucosa; Phosphotyrosine; Rats; Reference Values; Simian virus 40; Tyrosine | 1993 |
Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Macromolecular Substances; Mice; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.
Topics: Animals; Blood Cells; Cell Division; Cell Line; CHO Cells; Cricetinae; Culture Media, Serum-Free; DNA Replication; Electrophoresis, Polyacrylamide Gel; Insulin; Insulin-Like Growth Factor I; Interleukin-3; Interleukin-4; Kinetics; Mice; Peptide Mapping; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Thymidine; Transfection; Tyrosine | 1993 |
Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Codon; Fibroblasts; Humans; Interleukin-2; Kinetics; L Cells; Macromolecular Substances; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plasmids; Receptors, Interleukin-2; Recombinant Proteins; RNA; RNA, Messenger; Signal Transduction; Terminator Regions, Genetic; Transfection; Tyrosine | 1993 |
Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activity.
Topics: Adenosine Triphosphate; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Fluorides; Glutamates; Glutamic Acid; Humans; Male; Phosphorylation; Phosphotyrosine; Placenta; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptor, IGF Type 1; Receptor, Insulin; Sodium Fluoride; Tyrosine | 1993 |
Cationic liposome-mediated incorporation of prostatic acid phosphatase protein into human prostate carcinoma cells.
Topics: Acid Phosphatase; Cations; Fluorescent Antibody Technique; Humans; Male; Phosphatidylethanolamines; Phosphotyrosine; Prostatic Neoplasms; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
A dominant negative Raf-1 mutant prevents v-Src-induced transformation.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Diglycerides; Genes, Dominant; Mice; Mice, Inbred BALB C; Mutation; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine | 1993 |
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor.
Topics: Animals; Benzylidene Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Catechols; Enzyme Activation; Genes, fos; Nerve Growth Factors; Neurites; Nitriles; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, Nerve Growth Factor; RNA, Messenger; Type C Phospholipases; Tyrosine; Tyrphostins | 1993 |
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cytosol; Enzyme Activation; Humans; Kinetics; Liver; Macromolecular Substances; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphorylation; Phosphotransferases; Phosphotyrosine; Rats; Structure-Activity Relationship; Tyrosine | 1993 |
Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium; Catechols; DNA; DNA Replication; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gastrin-Releasing Peptide; Gene Expression; Genes, fos; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Molecular Weight; Myristoylated Alanine-Rich C Kinase Substrate; Nitriles; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptors, Cholecystokinin; Thymidine; Tyrosine; Tyrphostins | 1993 |
Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors.
Topics: Barium; Bradykinin; Calcium; Calcium-Transporting ATPases; Catechols; Cells, Cultured; Fibroblasts; Fura-2; Genistein; Humans; Immunoblotting; Isoflavones; Kinetics; Male; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Skin; Terpenes; Thapsigargin; Tyrosine; Tyrphostins | 1993 |
Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo.
Topics: Amino Acid Sequence; Animals; Antibodies; Blood Glucose; Cortisone; Diabetes Mellitus, Experimental; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Macromolecular Substances; Male; Molecular Sequence Data; Muscles; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Streptozocin; Tyrosine | 1993 |
Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol.
Topics: Amino Acid Sequence; Carrier Proteins; Computer Graphics; Isomerism; Mathematical Computing; Models, Molecular; Molecular Sequence Data; Myelin Basic Protein; Myelin P2 Protein; Oleic Acid; Oleic Acids; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Structure, Secondary; Receptors, Retinoic Acid; Reproducibility of Results; Sequence Homology, Amino Acid; Software; Tyrosine; Vitamin A; Water; X-Ray Diffraction | 1993 |
Reversible priming and protein-tyrosyl phosphorylation in human peripheral neutrophils under hypotonic conditions.
Topics: Amino Acid Sequence; Genistein; Humans; Isoflavones; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmotic Pressure; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Superoxides; Tyrosine | 1993 |
Increased neurite outgrowth induced by inhibition of protein tyrosine kinase activity in PC12 pheochromocytoma cells.
Topics: Adenosine Triphosphate; Animals; Catechols; Cell Differentiation; Cell Division; Electrophoresis, Polyacrylamide Gel; Genistein; Isoflavones; Kinetics; Molecular Weight; Nerve Growth Factors; Neurites; Nitriles; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Receptor, trkA; Tyrosine; Tyrphostins; Video Recording | 1993 |
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.
Topics: Amino Acid Sequence; Blotting, Western; Glutathione Transferase; Hematopoietic Cell Growth Factors; Humans; Macrophage Colony-Stimulating Factor; Megakaryocytes; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Colony-Stimulating Factor; Recombinant Fusion Proteins; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1993 |
A microtiter enzyme-linked immunosorbent assay for protein tyrosine phosphatase.
Topics: Enzyme-Linked Immunosorbent Assay; Humans; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Association of CD22 with the B cell antigen receptor.
Topics: Amino Acid Sequence; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Cell Adhesion Molecules; Cell Membrane; Humans; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; In Vitro Techniques; Lectins; Macromolecular Substances; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein Binding; Receptors, Antigen, B-Cell; Sialic Acid Binding Ig-like Lectin 2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Modulation of the activity and subcellular distribution of protein tyrosine kinases in human neutrophils by phorbol esters.
Topics: Adult; Amino Acid Sequence; Humans; Indoles; Molecular Sequence Data; Neutrophils; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Subcellular Fractions; Tyrosine | 1993 |
Effect of okadaic acid on apo B and apo A-I secretion by CaCo-2 cells.
Topics: Apolipoprotein A-I; Apolipoproteins B; Cell Line; Ethers, Cyclic; Humans; Intestines; Okadaic Acid; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Biosynthesis; RNA, Messenger; Tyrosine | 1993 |
Substrate specificity of the protein tyrosine phosphatases.
Topics: Amino Acid Sequence; ErbB Receptors; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Tyrosine; Yersinia | 1993 |
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cloning, Molecular; Escherichia coli; Genes, src; Glutathione Transferase; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 1993 |
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Topics: Animals; Female; Gene Expression; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Oocytes; Phosphoproteins; Phosphotyrosine; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Transfection; Tyrosine; Xenopus laevis; Xenopus Proteins | 1993 |
Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein.
Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; GTPase-Activating Proteins; Insulin; Kinetics; Phosphates; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptor, Insulin; Substrate Specificity; Sulfhydryl Compounds; Time Factors; Tyrosine | 1993 |
Inhibition of EGF-induced vasoconstriction in isolated rabbit aortic rings with the tyrosine kinase inhibitor RG50864.
Topics: Animals; Aorta, Abdominal; Catechols; Dose-Response Relationship, Drug; Epidermal Growth Factor; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Tyrphostins; Vasoconstriction | 1993 |
Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells.
Topics: Amino Acid Sequence; Blotting, Western; Cell Differentiation; Cell Division; Erythropoietin; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosorbent Techniques; Interleukin-3; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Immunosorbent Techniques; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Tyrosine | 1993 |
Sustained effect of angiotensin II on tyrosine phosphorylation of annexin I in glomerular mesangial cells.
Topics: Angiotensin II; Animals; Annexin A1; Calcium; Cells, Cultured; Chromatography, Affinity; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Glomerular Mesangium; Male; Molecular Weight; Phosphates; Phospholipids; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Tyrosine | 1993 |
Tyrosine kinase activity of the ret proto-oncogene products in vitro.
Topics: Amino Acids; Blotting, Western; Drosophila Proteins; Humans; Molecular Weight; Neuroblastoma; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1993 |
Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.
Topics: Animals; Cell Line; Ethers, Cyclic; Interleukin-2; Kinetics; Mice; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; T-Lymphocytes, Cytotoxic; Tyrosine; Vanadates | 1993 |
Insulin regulation of protein phosphorylation in H4 hepatoma cells. Examination of rapid effects using two-dimensional electrophoresis.
Topics: Animals; Arsenicals; Electrophoresis, Gel, Two-Dimensional; Insulin; Kinetics; Liver Neoplasms, Experimental; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Protease Inhibitors; Rats; Tumor Cells, Cultured; Tyrosine | 1993 |
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Cell Adhesion; Cell Movement; CHO Cells; Clone Cells; Cricetinae; Fibronectins; Flow Cytometry; Genetic Variation; Genetic Vectors; Humans; Integrin alpha5; Kinetics; Macromolecular Substances; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Receptors, Fibronectin; Recombinant Fusion Proteins; RNA, Messenger; Transfection; Tyrosine | 1993 |
Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells.
Topics: 3T3 Cells; Animals; CHO Cells; Cricetinae; Deoxyglucose; DNA; Enzyme Activation; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Division; ErbB Receptors; Female; Gene Expression; Humans; In Vitro Techniques; Phosphotyrosine; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vitamin A | 1993 |
Effect of indomethacin and aspirin on the TNF-alpha-induced priming and protein tyrosyl phosphorylation of human neutrophils.
Topics: Animals; Aspirin; Azides; Electrophoresis, Polyacrylamide Gel; Granulocyte Colony-Stimulating Factor; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sodium Azide; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Standardization of an enzyme-linked immunosorbent assay for the determination of protein tyrosine kinase activity.
Topics: Animals; Breast Neoplasms; Chemistry Techniques, Analytical; Detergents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Serum Albumin, Bovine; Spleen; Tissue Extracts; Trichloroacetic Acid; Tyrosine | 1993 |
Stimulation of protein tyrosine phosphorylation by a progesterone receptor on the cell surface of human sperm.
Topics: Adenosine Triphosphate; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Fluorescent Dyes; Genistein; Humans; Isoflavones; Male; Phosphoproteins; Phosphorylation; Phosphotyrosine; Progesterone; Protein-Tyrosine Kinases; Receptors, Progesterone; Serum Albumin, Bovine; Spermatozoa; Tyrosine | 1993 |
Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Ethers, Cyclic; Gene Expression; Genes, fos; Glycosylation; Guanosine Triphosphate; Insulin; Nerve Growth Factors; Okadaic Acid; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
Phosphotyrosine-containing proteins in the CNS of obese Zucker rats are decreased in the absence of changes in the insulin receptor.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Hippocampus; Immunohistochemistry; Insulin; Male; Molecular Sequence Data; Nerve Tissue Proteins; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prosencephalon; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Tyrosine | 1993 |
A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides.
Topics: Amino Acid Sequence; Catalysis; Kinetics; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tyrosine | 1993 |
Decrease in coupling of Gs in v-src-transformed NIH-3T3 fibroblasts: possible involvement of tyrosine phosphorylation of Gs by pp60v-src.
Topics: 3T3 Cells; Adenylyl Cyclases; Animals; Cell Transformation, Viral; Cyclic AMP; Genes, src; GTP-Binding Proteins; In Vitro Techniques; Iodocyanopindolol; Membrane Proteins; Mice; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Phosphotyrosine; Pindolol; Protein-Tyrosine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Tyrosine | 1993 |
Bradykinin receptors and signal transduction pathways in human fibroblasts: integral role for extracellular calcium.
Topics: Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Dinoprostone; Fibroblasts; Gingiva; Growth Substances; Humans; In Vitro Techniques; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Receptors, Bradykinin; Receptors, Neurotransmitter; Signal Transduction; Tyrosine | 1993 |
Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Calcium Chloride; Chlorides; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Heparin; Humans; Insulin; Kinetics; Manganese; Manganese Compounds; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Tyrosine | 1993 |
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.
Topics: Bronchi; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Doxorubicin; Emodin; Epithelium; Genes, ras; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1993 |
Granulocyte-macrophage colony stimulating factor stimulates rapid phosphorylation of proteins on tyrosines in human U937 and HL-60 leukemic cells.
Topics: Blotting, Western; Cells, Cultured; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Leukemia; Leukemia, Promyelocytic, Acute; Macrophage Colony-Stimulating Factor; Molecular Weight; Monocytes; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif.
Topics: CD3 Complex; Cytoplasm; Humans; In Vitro Techniques; Lymphocyte Activation; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1993 |
Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes.
Topics: Amino Acid Sequence; Animals; Anion Exchange Protein 1, Erythrocyte; ErbB Receptors; Humans; Isoenzymes; Liver; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Rats; Receptor, Insulin; Receptors, Platelet-Derived Growth Factor; Tyrosine; Xenopus | 1993 |
Downregulation of phospho-tyrosine phosphatases in a macrophage tumor.
Topics: Animals; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Rearrangement; Immunoblotting; Macrophages; Nucleic Acid Hybridization; Phosphotyrosine; Protein Biosynthesis; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; RNA, Messenger; Tumor Cells, Cultured; Tyrosine | 1993 |
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.
Topics: Adolescent; Adult; Blood Glucose; Cells, Cultured; Fasting; Female; Fibroblasts; Food; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine | 1993 |
Altered protein tyrosine phosphorylation in anergic Th1 cells.
Topics: Animals; Antigen-Presenting Cells; Antigens; CD3 Complex; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Clone Cells; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Phosphorylation; Phosphotyrosine; Signal Transduction; T-Lymphocytes, Helper-Inducer; Tyrosine | 1993 |
Stem cell factor-induced signal transduction in rat mast cells. Activation of phospholipase D but not phosphoinositide-specific phospholipase C in c-kit receptor stimulation.
Topics: Animals; Antigens; Diglycerides; Genistein; Hematopoietic Cell Growth Factors; Isoflavones; Mast Cells; Peritoneal Cavity; Phosphatidic Acids; Phosphatidylinositols; Phospholipase D; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Rats; Rats, Wistar; Second Messenger Systems; Secretory Rate; Serotonin; Signal Transduction; Stem Cell Factor; Type C Phospholipases; Tyrosine | 1993 |
Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C.
Topics: Catechols; Genistein; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Monocytes; Naphthalenes; Nitriles; Phosphoproteins; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine; Tyrphostins; Vanadium; Zymosan | 1993 |
Mouse osteopontin expressed in E. coli exhibits autophosphorylating activity of tyrosine residues.
Topics: Animals; Cloning, Molecular; Escherichia coli; Glutathione Transferase; Mice; Molecular Weight; Osteopontin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Recombinant Proteins; Sialoglycoproteins; Tyrosine | 1993 |
Involvement of GPIIb-IIIa on human platelets in phosphotyrosine-specific dephosphorylation.
Topics: Amino Acid Sequence; Antibodies; Antibodies, Monoclonal; Blood Platelets; Humans; Immunoblotting; In Vitro Techniques; Kinetics; Molecular Weight; Oligopeptides; Phosphoproteins; Phosphotyrosine; Platelet Membrane Glycoproteins; Reference Values; Thrombasthenia; Thrombin; Thromboxane A2; Tyrosine | 1993 |
Protein kinase C forms a complex with and phosphorylates the GTPase activating protein GAP: phosphorylation by PKC is dependent on tyrosine phosphorylation of GAP and/or a GAP-associated protein.
Topics: Animals; Cytosol; Electrophoresis, Polyacrylamide Gel; Epidermis; GTPase-Activating Proteins; Immunoblotting; Lung; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proteins; Recombinant Proteins; Tyrosine | 1993 |
The lectin concanavalin A stimulates a protein-tyrosine kinase p72syk in peripheral blood lymphocytes.
Topics: Animals; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Precursors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lymphocytes; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Swine; Syk Kinase; Tyrosine | 1993 |
Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors.
Topics: Antigens, Bacterial; Calcium; Cell Division; Cell Transformation, Viral; Clone Cells; Herpesvirus 2, Saimiriine; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; T-Lymphocytes; Tetanus Toxoid; Tyrosine | 1993 |
Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells.
Topics: Animals; Cell Compartmentation; Cell Membrane Permeability; Enzyme Activation; In Vitro Techniques; Isoenzymes; Mast Cells; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Receptor Aggregation; Receptors, IgE; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vanadates | 1993 |
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.
Topics: Amino Acid Sequence; Binding, Competitive; Cloning, Molecular; Hepatocyte Growth Factor; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptors, Cell Surface; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1993 |
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Blotting, Western; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Oncogene Protein v-crk; Oncogenes; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tyrosine; Vanadates | 1993 |
Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis.
Topics: CDC28 Protein Kinase, S cerevisiae; Cell Cycle; DNA Replication; Gene Expression Regulation, Fungal; Genes, src; Mitosis; Oncogene Protein pp60(v-src); Phosphotyrosine; Saccharomyces cerevisiae; Transformation, Genetic; Tyrosine | 1993 |
Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).
Topics: Animals; Base Sequence; Cell Line; Enzyme Activation; Escherichia coli; Fusion Proteins, gag-onc; Gene Deletion; Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; Tyrosine | 1993 |
The hypophyseal pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary.
Topics: Animals; Blotting, Western; Brain; Brain Chemistry; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Immunohistochemistry; Male; Median Eminence; Microscopy, Electron; Phosphorylation; Phosphotyrosine; Pituitary Gland; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine | 1993 |
Identification of O-phosphoamino acids in urine hydrolysate by gas chromatography-mass spectrometry.
Topics: Amino Acids; Chromatography, DEAE-Cellulose; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Phosphoserine; Phosphothreonine; Phosphotyrosine; Photometry; Tyrosine | 1993 |
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Calbindins; Cell Survival; Cells, Cultured; Gene Expression; Genes, fos; Hippocampus; Membrane Glycoproteins; Membrane Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptor, trkC; RNA, Messenger; S100 Calcium Binding Protein G; Tyrosine | 1993 |
Tyrosine phosphorylation in early embryonic growth cones.
Topics: Amino Acid Sequence; Animals; Axons; Blotting, Western; Brain; Chick Embryo; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; GAP-43 Protein; Membrane Glycoproteins; Microscopy, Electron; Molecular Sequence Data; Nerve Tissue Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1993 |
Comparative analysis of phosphotyrosyl polypeptides in normal and leukemic human T lymphocytes activated via CD3 or CD2.
Topics: Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia-Lymphoma, Adult T-Cell; Lymphocyte Activation; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Immunologic; T-Lymphocyte Subsets; Tumor Cells, Cultured; Tyrosine | 1993 |
Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.
Topics: Amino Acid Sequence; Biological Transport; CD4 Antigens; CD8 Antigens; Cell Membrane; Cells, Cultured; Cholera Toxin; Cyclic AMP; Enzyme Induction; HIV; Humans; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Toxoids; Tyrosine; Viral Proteins | 1993 |
Tyrosine phosphorylation of PLC-gamma 1 induced by electroconvulsive shock in rat hippocampus.
Topics: Animals; Electroshock; Enzyme Induction; Hippocampus; Immunoblotting; Isoenzymes; Kinetics; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases; Tyrosine | 1993 |
Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.
Topics: Adenocarcinoma; Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; DNA; DNA, Neoplasm; Embryonic and Fetal Development; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Molecular Sequence Data; Open Reading Frames; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Rats; Rats, Wistar; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Stomach; Stomach Neoplasms; Tyrosine | 1993 |
Drastic reduction of the zinc- and magnesium-stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Female; Hippocampus; Humans; Magnesium; Male; Middle Aged; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tyrosine; Zinc | 1993 |
Pool of ligand-bound platelet-derived growth factor beta-receptors remain activated and tyrosine phosphorylated after internalization.
Topics: Animals; Aorta; Blotting, Western; Cell Line; Endocytosis; Endothelium, Vascular; Fluorescent Antibody Technique; Hydrogen-Ion Concentration; Intracellular Membranes; Isomerism; Ligands; Microscopy, Fluorescence; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Receptors, Platelet-Derived Growth Factor; Swine; Time Factors; Tyrosine | 1993 |
Platelet-activating factor triggers the phosphorylation and activation of MAP-2 kinase and S6 peptide kinase activity in human B cell lines.
Topics: B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; Myelin Basic Protein; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Ribosomal Protein S6 Kinases; Time Factors; Tyrosine | 1993 |
Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226.
Topics: Glucose; Humans; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Lactates; Mitosis; Multiple Myeloma; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells.
Topics: Actin Cytoskeleton; Actins; CD3 Complex; Cell Adhesion; Cell Division; Cytochalasin D; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptors, Transferrin; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1993 |
Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels.
Topics: Antigens, CD; Antigens, Surface; Apoptosis; B-Lymphocytes; Cells, Cultured; Glutathione; Humans; In Vitro Techniques; Lymphocyte Activation; Membrane Proteins; Mercaptoethanol; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Sulfhydryl Compounds; Tetraspanin 28; Tyrosine | 1993 |
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
Topics: Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Macromolecular Substances; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Platelet-Derived Growth Factor; Tumor Cells, Cultured; Tyrosine | 1993 |
Heat-shock protein hsp90 governs the activity of pp60v-src kinase.
Topics: Cell Cycle; Chromosome Deletion; Gene Expression; Genes, Fungal; Heat-Shock Proteins; Mutagenesis, Insertional; Oncogene Protein pp60(v-src); Oncogene Proteins v-abl; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Saccharomyces cerevisiae; Tyrosine | 1993 |
Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.
Topics: Calcium; CD4-Positive T-Lymphocytes; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor Aggregation; Receptors, Antigen, T-Cell; Signal Transduction; Type C Phospholipases; Tyrosine | 1993 |
Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; DNA Mutational Analysis; Down-Regulation; Glycogen; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, Insulin; Recombinant Fusion Proteins; Structure-Activity Relationship; Tyrosine | 1993 |
Vanadate-induced contraction of smooth muscle and enhanced protein tyrosine phosphorylation.
Topics: Animals; Calcium; Genistein; Guinea Pigs; Intestine, Large; Isoflavones; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosins; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vanadates | 1993 |
Changes of the phosphorylation of membrane-associated proteins following treatment of HeLa cells with the guanine analogue, queuine.
Topics: Adenosine Triphosphate; Epidermal Growth Factor; Guanine; HeLa Cells; Humans; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1993 |
Activation and inhibition of insulin receptor autophosphorylation by trypsin treatment of intact H35 cells.
Topics: Adenosine Triphosphate; Animals; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Trypsin; Tumor Cells, Cultured; Tyrosine | 1993 |
Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Humans; Interleukin-2; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptors, Interleukin-2; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; T-Lymphocytes, Cytotoxic; Tyrosine | 1993 |
Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.
Topics: Animals; Chick Embryo; CSK Tyrosine-Protein Kinase; Fibroblasts; Genes, src; Glutathione Transferase; Mutagenesis, Site-Directed; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Restriction Mapping; Saccharomyces cerevisiae; Sequence Deletion; src-Family Kinases; Transformation, Genetic; Tyrosine | 1993 |
Downstream signal transduction defects that suppress transformation in two revertant cell lines expressing activated rat neu oncogene.
Topics: 3T3 Cells; Animals; Blotting, Southern; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; Ethyl Methanesulfonate; Mice; Mutagenesis; Oncogenes; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Receptors, Cell Surface; Restriction Mapping; Signal Transduction; Tyrosine | 1993 |
ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Blood Proteins; Calcium; Calcium-Transporting ATPases; Cinnamates; Fluorescent Dyes; Fura-2; Genistein; Humans; In Vitro Techniques; Isoflavones; Kinetics; Phosphotyrosine; Protein-Tyrosine Kinases; Terpenes; Thapsigargin; Time Factors; Tyrosine | 1993 |
A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor.
Topics: Cell Line; Cell Membrane; Chromatography, Gel; Gene Expression; Hepatocyte Growth Factor; Humans; Kinetics; Oncogenes; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Recombinant Proteins; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a human epidermal growth factor receptor-associated protein kinase as a new member of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase family.
Topics: Amino Acid Sequence; Animals; Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Humans; Isoenzymes; Kidney Neoplasms; Molecular Sequence Data; Molecular Weight; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Rats; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wilms Tumor | 1993 |
Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotype.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Line; Cell Transformation, Viral; Eflornithine; GTPase-Activating Proteins; Oncogene Protein pp60(v-src); Ornithine Decarboxylase; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Polyamines; Proteins; ras GTPase-Activating Proteins; Rats; Signal Transduction; Tyrosine | 1993 |
Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.
Topics: Acquired Immunodeficiency Syndrome; Benzoquinones; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Membrane; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Activation; Growth Inhibitors; Humans; Kinetics; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Oncostatin M; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Sarcoma, Kaposi; Thymidine; Tumor Cells, Cultured; Tyrosine; Umbilical Veins | 1993 |
Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.
Topics: Amino Acid Sequence; Antigens, CD; Calcium; CD79 Antigens; Cytoplasm; DNA Mutational Analysis; Enzyme Activation; Humans; Immunoglobulin alpha-Chains; Immunoglobulin M; In Vitro Techniques; Macromolecular Substances; Membrane Glycoproteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tyrosine | 1993 |
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Compartmentation; Cell Membrane; Cells, Cultured; Chick Embryo; In Vitro Techniques; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Tyrosine | 1993 |
Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.
Topics: Cell Division; CSK Tyrosine-Protein Kinase; DNA Mutational Analysis; Oncogene Protein pp60(v-src); Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Saccharomyces cerevisiae; src-Family Kinases; Structure-Activity Relationship; Tyrosine | 1993 |
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Gene Expression; Genes; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Oncogene Proteins; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Binding; Proteins; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Tyrosine | 1993 |
Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.
Topics: Animals; Antigens; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Thymus Gland; Tyrosine | 1993 |
eps15, a novel tyrosine kinase substrate, exhibits transforming activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Calcium-Binding Proteins; Cell Compartmentation; Cell Division; Cell Transformation, Neoplastic; Cloning, Molecular; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Sequence Alignment; Signal Transduction; Tyrosine | 1993 |
Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.
Topics: Animals; Cell Transformation, Viral; Chick Embryo; DNA Mutational Analysis; Gene Expression Regulation, Enzymologic; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tyrosine; Urokinase-Type Plasminogen Activator | 1993 |
Identification and pKa determination of the histidine residues of human low-molecular-weight phosphotyrosyl protein phosphatases: a convenient approach using an MLEV-17 spectral editing scheme.
Topics: Amino Acid Sequence; Base Sequence; Histidine; Humans; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphotyrosine; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Recombinant Proteins; Tyrosine; Vanadates | 1993 |
Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Differentiation; CHO Cells; Chromatography; Cricetinae; ErbB Receptors; Glycoproteins; Humans; Liver Neoplasms; Molecular Sequence Data; Molecular Weight; Neuregulins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-4; Receptors, Cell Surface; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibroblasts; Humans; Immunoblotting; Immunosorbent Techniques; Phosphorylation; Phosphotyrosine; Protein Kinases; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons.
Topics: Alzheimer Disease; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Electrophoresis, Polyacrylamide Gel; Female; Fluorescent Antibody Technique; Hippocampus; Humans; Microinjections; Microtubules; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Phosphotyrosine; Pregnancy; Rats; tau Proteins; Tyrosine | 1993 |
The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Aggregation; Cell Movement; Cell Size; Epidermal Growth Factor; ErbB Receptors; Genistein; Hepatocyte Growth Factor; Isoflavones; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1993 |
Selective association of the p59fyn tyrosine kinase with murine T lymphoma membrane phosphoproteins.
Topics: Animals; Cell Cycle Proteins; Electrophoresis, Gel, Two-Dimensional; Lymphoma, T-Cell; Macromolecular Substances; Membrane Proteins; Mice; Oncogene Protein v-crk; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-vav; Retroviridae Proteins, Oncogenic; Tyrosine | 1993 |
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Rats; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Type C Phospholipases; Tyrosine | 1993 |
Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.
Topics: Animals; Antigens, Polyomavirus Transforming; Cell Transformation, Viral; Cells, Cultured; Gene Expression Regulation, Viral; In Vitro Techniques; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Tyrosine | 1993 |
Responses of smooth muscle cells to platelet-derived growth factor are inhibited by herbimycin-A tyrosine kinase inhibitor.
Topics: Actins; Animals; Benzoquinones; Cell Division; Cell Line; Dose-Response Relationship, Drug; Kinetics; Lactams, Macrocyclic; Muscle, Smooth, Vascular; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Pulmonary Artery; Quinones; Rats; Rifabutin; Tyrosine | 1993 |
Thrombin activation of human platelets causes tyrosine phosphorylation of PLC-gamma 2.
Topics: Antibodies; Blood Platelets; Cross Reactions; Enzyme Activation; Humans; Isoenzymes; Phosphorylation; Phosphotyrosine; Platelet Activation; Thrombin; Type C Phospholipases; Tyrosine | 1993 |
Basic fibroblast growth factor (bFGF) receptors decrease with luteal age in rat ovarian luteal cells: colocalization of bFGF receptors and bFGF in luteal cells.
Topics: Animals; Base Sequence; Blotting, Northern; Cell Membrane; Corpus Luteum; Female; Fibroblast Growth Factor 2; Gene Expression; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Luteal Cells; Molecular Sequence Data; Phosphotyrosine; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptors, Fibroblast Growth Factor; RNA, Messenger; Tyrosine | 1993 |
Cross-talk between adenylate cyclase activation and tyrosine phosphorylation leads to modulation of the actin cytoskeleton and to acute progesterone secretion in ovarian granulosa cells.
Topics: Actins; Adenylyl Cyclases; Animals; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Cytoskeleton; Enzyme Activation; Female; Follicle Stimulating Hormone; Granulosa Cells; Hydrogen Peroxide; Microscopy, Electron; Phosphorylation; Phosphotyrosine; Progesterone; Rats; Tyrosine; Vanadates | 1993 |
Glucose transporter recycling in rat adipose cells. Effects of potassium depletion.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Blotting, Western; Cell Membrane; In Vitro Techniques; Insulin; Intracellular Membranes; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Potassium; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 2; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Topics: Animals; Antibodies; Apoptosis; Cell Division; DNA Damage; DNA, Neoplasm; Immunoglobulin mu-Chains; Kinetics; Lymphoma, B-Cell; Methionine; Mice; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured; Tyrosine | 1993 |
Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck.
Topics: Cell Cycle Proteins; Humans; Immunoblotting; Immunosorbent Techniques; Interleukin-2; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphoma; Mutation; Phosphotyrosine; Phytohemagglutinins; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1993 |
Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.
Topics: Arachidonic Acid; Cells, Cultured; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrolysis; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Keratinocytes; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylcholines; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proteins; Transforming Growth Factor alpha; Type C Phospholipases; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Pleiotrophin stimulates tyrosine phosphorylation in NIH 3T3 and NB41A3 cells.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Autoradiography; Carrier Proteins; Cytokines; Electrophoresis, Polyacrylamide Gel; Mice; Mitogens; Molecular Weight; Neuroblastoma; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1993 |
The insulin receptor C-terminus is involved in regulation of the receptor kinase activity.
Topics: Adenosine Triphosphate; Animals; Cytoplasm; Humans; Immunologic Techniques; In Vitro Techniques; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Recombinant Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 1993 |
Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses.
Topics: Animals; Blood Platelets; Cells, Cultured; Genistein; Inositol 1,4,5-Trisphosphate; Ionomycin; Isoflavones; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1993 |
Resistance of NIH3T3 cells to v-fes transformation induced by a dominant negative H-ras mutant.
Topics: 3T3 Cells; Animals; Cell Transformation, Viral; Fusion Proteins, gag-onc; Gene Expression Regulation, Viral; Genes, Dominant; Genes, ras; Mice; Oncogene Proteins, Viral; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Tyrosine | 1993 |
Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.
Topics: Benzoquinones; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Genistein; Humans; Hypotonic Solutions; Intestines; Iodides; Isoflavones; Kinetics; Lactams, Macrocyclic; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Rubidium; Tyrosine; Vanadates; Water-Electrolyte Balance | 1993 |
Phosphoenolpyruvate and creatine phosphate augment ATP and magnesium-dependent, Fc epsilon RI-mediated activation of phospholipase C in RBL cell ghosts.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Enzyme Activation; In Vitro Techniques; Magnesium; Mast Cells; Phosphocreatine; Phosphoenolpyruvate; Phosphoproteins; Phosphotyrosine; Rats; Receptors, IgE; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1993 |
Interactions of the SH2 domain of lymphocyte-specific tyrosine protein kinase p56lck with phosphotyrosine-containing proteins.
Topics: Animals; Hybridomas; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Organophosphates; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1993 |
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Topics: Amino Acid Sequence; Cell Line; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon-gamma; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Signal Transduction; Transcription Factors; Transcriptional Activation; Transfection; Tyrosine | 1993 |
Vinculin is a major platelet protein that undergoes Ca(2+)-dependent tyrosine phosphorylation.
Topics: Antigens, Differentiation, Myelomonocytic; Blood Platelets; Calcium; Glycoside Hydrolases; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Platelet Activation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Tyrosine; Vinculin | 1993 |
Distinct beta-subunits are present in hybrid insulin-like-growth-factor-1 receptors in the central nervous system.
Topics: Animals; Brain Chemistry; Insulin-Like Growth Factor I; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphotyrosine; Precipitin Tests; Rats; Receptor, IGF Type 1; Receptor, Insulin; Synaptosomes; Tyrosine | 1993 |
Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism.
Topics: Amino Acid Sequence; Binding Sites; Electrophoresis, Polyacrylamide Gel; GTPase-Activating Proteins; Immunoblotting; Immunosorbent Techniques; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fes; ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Trypsin; Tyrosine | 1993 |
Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo.
Topics: Actin Cytoskeleton; Animals; Cell Compartmentation; Cell Division; Concanavalin A; Cytoskeleton; Dictyostelium; Membrane Proteins; Mutation; Myosins; Octoxynol; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Tyrosine | 1993 |
Human growth hormone (GH) receptor is characterized as the 134-kilodalton tyrosine-phosphorylated protein activated by GH treatment in IM-9 cells.
Topics: Antibodies, Monoclonal; Blotting, Western; Carbohydrate Conformation; Cell Line; Embryo, Mammalian; Glycoside Hydrolases; Glycosylation; Growth Hormone; Humans; Immunosorbent Techniques; Kidney; Molecular Weight; Phosphorylation; Phosphotyrosine; Receptors, Somatotropin; Recombinant Proteins; Transfection; Tyrosine | 1993 |
Synthesis of phosphotyrosine-containing peptides by the solid-phase method. A re-examination of the use of Boc-Tyr(PO3Bzl2)-OH.
Topics: Amino Acid Sequence; Anion Exchange Protein 1, Erythrocyte; Dimethylformamide; Methylene Chloride; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphotyrosine; Tyrosine | 1993 |
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
Topics: Animals; Binding Sites; Cells, Cultured; Dogs; Enzyme Activation; Humans; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1993 |
The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain.
Topics: CDC28 Protein Kinase, S cerevisiae; Cell Cycle; Enzyme Activation; Fungal Proteins; Gene Expression Regulation, Fungal; Oncogene Protein pp60(v-src); Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protamine Kinase; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sequence Deletion; Tyrosine | 1993 |
Crystal-induced neutrophil activation. IV. Specific inhibition of tyrosine phosphorylation by colchicine.
Topics: Blood Proteins; Calcium Pyrophosphate; Colchicine; Crystallization; Demecolcine; Humans; In Vitro Techniques; Indomethacin; Kinetics; Neutrophils; Nocodazole; Phenylbutazone; Phosphorylation; Phosphotyrosine; Tyrosine; Uric Acid; Vinblastine | 1993 |
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA Primers; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Leukemia, Mast-Cell; Mice; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Macromolecular Substances; Mice; Mice, Obese; Muscles; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Tyrosine | 1993 |
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Topics: Amino Acid Sequence; Animals; Antibodies; Dexamethasone; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Liver; Male; Molecular Sequence Data; Muscles; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1993 |
Co-stimulatory signal delivered by CD73 molecule to human CD45RAhiCD45ROlo (naive) CD8+ T lymphocytes.
Topics: 5'-Nucleotidase; CD3 Complex; CD8 Antigens; Cells, Cultured; Humans; Leukocyte Common Antigens; Lymphocyte Activation; Phosphotyrosine; T-Lymphocyte Subsets; T-Lymphocytes; Tyrosine | 1993 |
Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Carrier Proteins; Electrophoresis, Gel, Two-Dimensional; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Helix-Loop-Helix Motifs; Immunosorbent Techniques; Insulin; Isoelectric Point; Molecular Sequence Data; Muscle Proteins; Myocardium; Neoplasm Proteins; Nerve Tissue Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Substrate Specificity; Tyrosine | 1993 |
Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions.
Topics: Amino Acid Sequence; Base Sequence; DNA Mutational Analysis; Humans; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Sequence Deletion; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1993 |
Functional role of GTPase-activating protein in cell transformation by pp60v-src.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Cell Transformation, Neoplastic; Gene Expression; Genes, ras; Genes, src; GTPase-Activating Proteins; Humans; Isoenzymes; Kinetics; Macromolecular Substances; Mice; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Biosynthesis; Proteins; ras GTPase-Activating Proteins; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1993 |
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
Topics: Amino Acid Sequence; Animals; Becaplermin; Binding Sites; Cells, Cultured; Dogs; Epithelium; Glutathione Transferase; Humans; Kidney; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Female; Gene Expression; Mice; Molecular Sequence Data; Moths; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Transfection; Tyrosine; Xenopus laevis | 1993 |
Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1993 |
Morphological transformation, tumorigenicity and src-specific cytotoxic T-lymphocyte-mediated tumor immunity induced by murine 3T3 cells expressing src oncogenes encoding novel non-myristylated N-terminal domains.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; Genes, src; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms, Experimental; Phosphotyrosine; T-Lymphocytes, Cytotoxic; Tyrosine | 1993 |
Potential role of growth factors in global brain ischemia and reperfusion. Observation of insulin-driven tyrosine phosphorylation of a 90-kDa protein during reperfusion.
Topics: Animals; Blotting, Western; Brain; Electrophoresis, Polyacrylamide Gel; Heart Arrest; Insulin; Ischemic Attack, Transient; Molecular Weight; Nerve Tissue Proteins; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Reperfusion; Resuscitation; Tyrosine | 1993 |
Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Base Sequence; Cell Adhesion Molecules; Chickens; Cloning, Molecular; DNA, Complementary; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; In Vitro Techniques; Leukemia, B-Cell; Leukemia, T-Cell; Mice; Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine phosphorylation of alpha-tubulin is an early response to NGF and pp60v-src in PC12 cells.
Topics: Animals; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Metallothionein; Mice; Neoplasm Proteins; Nerve Growth Factors; Oncogene Protein pp60(v-src); PC12 Cells; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Recombinant Fusion Proteins; Tubulin; Tyrosine | 1993 |
Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding.
Topics: Amino Acid Sequence; Binding Sites; Circular Dichroism; Glutathione Transferase; Humans; Models, Structural; Molecular Sequence Data; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphopeptides; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Structure, Secondary; Recombinant Fusion Proteins; Thrombin; Trypsin; Tyrosine | 1993 |
Inhibitory effects of alpha-interferon on epidermal growth factor-mediated receptor-dependent events.
Topics: Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescein-5-isothiocyanate; Glioblastoma; Humans; Interferon Type I; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1993 |
Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Fibroblasts; Insulin; Kinetics; Lovastatin; Macromolecular Substances; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1993 |
Differential activities of protein tyrosine phosphatases in intact cells.
Topics: Base Sequence; Cell Line; Cloning, Molecular; DNA Primers; Enzyme Activation; Gene Expression; Humans; Kidney; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Restriction Mapping; Transfection; Tyrosine | 1993 |
Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells.
Topics: Actins; Animals; Arachidonic Acid; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Electrophoresis, Polyacrylamide Gel; Exocytosis; Hexosaminidases; Hydrogen Peroxide; Inositol Phosphates; Kinetics; Leukemia, Basophilic, Acute; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.
Topics: Cell Line; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-2; Kinetics; Lymphocyte Activation; Macromolecular Substances; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Interleukin-2; T-Lymphocytes; Tyrosine | 1993 |
Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA Primers; DNA, Complementary; Enzyme Precursors; Gene Expression; Intracellular Signaling Peptides and Proteins; Mast Cells; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptors, IgE; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Syk Kinase; Tyrosine | 1993 |
Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Cycle; Humans; In Vitro Techniques; Insulin-Like Growth Factor I; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1993 |
Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cysteine; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphopeptides; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Structure-Activity Relationship; Substrate Specificity; Type C Phospholipases; Tyrosine | 1993 |
Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression.
Topics: Arsenicals; Calcium; CD3 Complex; Dimercaprol; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Leukocyte Common Antigens; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; T-Lymphocytes; Tyrosine | 1993 |
PDGF stimulation induces phosphorylation of talin and cytoskeletal reorganization in skeletal muscle.
Topics: Animals; Calpain; Cell Line; Cytoskeleton; Enzyme Activation; Fluorescent Antibody Technique; Muscles; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Platelet-Derived Growth Factor; Talin; Tyrosine | 1993 |
Regulated tyrosine phosphorylation at the tips of growth cone filopodia.
Topics: Animals; Aplysia; Cytoskeleton; Genistein; Hemolymph; Isoflavones; Neurons; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.
Topics: Antibodies, Monoclonal; CD8 Antigens; Cloning, Molecular; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 1993 |
Tyrosine phosphorylation and association with phospholipase C gamma-1 of the GAP-associated 62-kD protein after CD2 stimulation of Jurkat T cell.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Cell Line; GTPase-Activating Proteins; Humans; Inositol Phosphates; Isoenzymes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Immunologic; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1993 |
Phosphorylation of two human neurochordins by mammalian casein kinase 1.
Topics: Adenosine Triphosphate; Adolescent; Autoradiography; Brain; Casein Kinases; Electrophoresis, Polyacrylamide Gel; Female; Humans; Membrane Glycoproteins; Molecular Weight; Nerve Tissue Proteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1993 |
Molecular modeling and site-directed mutagenesis of an anti-phosphotyrosine antibody predicts the combining site and allows the detection of higher affinity interactions.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigen-Antibody Reactions; Binding Sites, Antibody; Blotting, Western; Computer Simulation; Crystallography, X-Ray; Enzyme-Linked Immunosorbent Assay; Immunoglobulin Fab Fragments; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Polymerase Chain Reaction; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid; Templates, Genetic; Tyrosine | 1993 |
The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Chromatography, Affinity; DNA Primers; Glutathione Transferase; GTPase-Activating Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Tyrosine | 1993 |
Increasing cAMP attenuates activation of mitogen-activated protein kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Animals; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epididymis; Glucagon; Isoenzymes; Isoproterenol; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Thionucleotides; Tyrosine | 1993 |
Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4.
Topics: Base Sequence; Binding Sites; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-4; Molecular Sequence Data; Monocytes; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Receptors, IgG; Signal Transduction; Transcription Factors; Tyrosine | 1993 |
[Studies on the phospho-tyrosine proteins during the proliferation cycle of cultured aortic smooth muscle cells].
Topics: Animals; Aorta, Thoracic; Cell Cycle; Cell Division; Cells, Cultured; Muscle, Smooth, Vascular; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine | 1993 |
Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism.
Topics: Animals; Cell Division; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; gamma-Linolenic Acid; Genes, fos; Immediate-Early Proteins; Immunohistochemistry; Kinetics; Liver; Male; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Transcription Factors; Tyrosine; Zinc Fingers | 1993 |
Dephosphorylation on tyrosine of epidermal growth factor receptor is inhibited by Ca2+ pretreatment in isolated liver membrane.
Topics: Adenosine Triphosphate; Animals; Cadaverine; Calcium; Cell Membrane; ErbB Receptors; Immunoblotting; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Tyrosine; Vanadates | 1993 |
Dynamics of connexin43 phosphorylation in pp60v-src-transformed cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line, Transformed; Connexin 43; Fibroblasts; Immunosorbent Techniques; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; RNA, Messenger; Transformation, Genetic; Tyrosine | 1993 |
Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate.
Topics: Animals; Drug Synergism; Enzyme Activation; Female; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1993 |
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Division; Gene Expression; Genes, myc; Humans; Immunoblotting; Interleukin-7; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1993 |
Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cells, Cultured; Cricetinae; DNA Primers; Fibroblasts; Humans; Insulin; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein Conformation; Receptors, Adrenergic, beta-2; Structure-Activity Relationship; Transfection; Tyrosine | 1995 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Benzylidene Compounds; Cell Differentiation; Cell Line; Colonic Neoplasms; Colorectal Neoplasms; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Microscopy, Electron, Scanning; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1995 |
Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast Neoplasms; Chromatography, Affinity; Cytosol; DNA-Binding Proteins; Estradiol; Female; Humans; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligonucleotide Probes; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptors, Estrogen; Recombinant Proteins; Spodoptera; Transfection; Tumor Cells, Cultured; Tyrosine; Xenopus | 1995 |
Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc.
Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; src Homology Domains; Tyrosine | 1995 |
Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins.
Topics: Adenocarcinoma; Bacterial Adhesion; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Escherichia coli; Fluorescent Antibody Technique; Helicobacter pylori; Humans; Microscopy, Confocal; Microscopy, Electron; Microscopy, Immunoelectron; Microvilli; Phosphoproteins; Phosphorylation; Phosphotyrosine; Stomach Neoplasms; Tumor Cells, Cultured; Tyrosine | 1996 |
Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Enzyme Activation; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Molecular Sequence Data; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Type C Phospholipases; Tyrosine | 1996 |
Inhibition of protein tyrosine kinases impairs axon extension in the embryonic optic tract.
Topics: Animals; Antibody Specificity; Axons; Benzoquinones; Cells, Cultured; Chick Embryo; Ciliary Body; Embryo, Nonmammalian; Enzyme Inhibitors; Ganglia; Lactams, Macrocyclic; Neurites; Neurons; Optic Nerve; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retina; Rifabutin; Signal Transduction; Superior Colliculi; Tyrosine; Visual Pathways; Xenopus laevis | 1996 |
Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Interactions; Female; Humans; Insulin; Liver Neoplasms; Mice; Neoplasm Proteins; Neoplasms; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine | 1996 |
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
Topics: Alleles; Aluminum Compounds; Animals; Animals, Newborn; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fluorides; Gene Expression; Genes, ras; GTP-Binding Proteins; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Signal Transduction; Spodoptera; Transfection; Transforming Growth Factor alpha; Tyrosine | 1996 |
Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Cell Differentiation; Crk-Associated Substrate Protein; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Nerve Growth Factors; Oncogene Protein v-crk; PC12 Cells; Peptide Fragments; Pheochromocytoma; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Rats; Recombinant Fusion Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Tyrosine | 1996 |
Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Cell Membrane; DNA Mutational Analysis; Gene Expression; Genes, fos; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Macromolecular Substances; Mice; Models, Biological; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; ras Proteins; Rats; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Transcription, Genetic; Transfection; Tyrosine | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
c-kit ligand stimulates tyrosine phosphorylation of a similar pattern of phosphotyrosyl proteins in primary primitive normal hematopoietic progenitors that are constitutively phosphorylated in comparable primitive progenitors in chronic phase chronic myel
Topics: Cell Lineage; Electrophoresis, Polyacrylamide Gel; Fusion Proteins, bcr-abl; GTPase-Activating Proteins; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Immunoblotting; Leukemia, Myeloid, Chronic-Phase; Neoplastic Stem Cells; Phosphorylation; Phosphotyrosine; Precipitin Tests; Proteins; ras GTPase-Activating Proteins; Signal Transduction; Stem Cell Factor; Tyrosine | 1996 |
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
Topics: Animals; Cells, Cultured; Flow Cytometry; Immunoblotting; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Phosphotyrosine; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; src-Family Kinases; T-Lymphocytes; Thymus Gland; Tyrosine | 1996 |
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
Topics: Base Sequence; Binding Sites; Cell Line; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cytokines; DNA-Binding Proteins; Enzyme Activation; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; HL-60 Cells; Humans; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 1996 |
Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells.
Topics: Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Base Sequence; Cell Line, Transformed; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phosphotyrosine; Precipitin Tests; Protein Binding; Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Vascular Endothelial Growth Factor Receptor-3 | 1996 |
Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor.
Topics: Animals; Bradykinin; Cell Line; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Insulin-Like Growth Factor I; Kidney; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Recombinant Proteins; Skin; Transfection; Tyrosine | 1996 |
Tyrosine phosphorylation in inflammatory neutrophils.
Topics: Arthritis, Rheumatoid; Blotting, Western; Enzyme Inhibitors; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidoreductases; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Reference Values; Substance P; Synovial Fluid; Tyrosine; Vanadates | 1996 |
4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.
Topics: Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry, Physical; Cricetinae; Enzyme Inhibitors; Fluorine; Humans; Ions; Models, Molecular; Molecular Sequence Data; Molecular Structure; Peptides; Phosphotyrosine; Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Tyrosine | 1996 |
Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein.
Topics: Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cytosol; Heart Ventricles; Hypertension; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Myocardium; Phosphorylation; Phosphotyrosine; Precipitin Tests; Rats; Rats, Mutant Strains; Sodium Chloride, Dietary; Tyrosine | 1996 |
Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Chlorocebus aethiops; DNA-Binding Proteins; Humans; Janus Kinase 1; Lymphocyte Activation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Receptor Aggregation; Receptors, Interleukin-2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 1996 |
Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.
Topics: Amino Acid Sequence; Base Sequence; Cell Division; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Milk Proteins; Molecular Sequence Data; Oligonucleotide Probes; Phosphotyrosine; Point Mutation; Protein Binding; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Tyrosine | 1996 |
Tyrosine phosphorylation: past, present and future.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Line, Transformed; Humans; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1996 |
Tyrosine phosphorylation in Myxococcus xanthus, a multicellular prokaryote.
Topics: Antibodies, Monoclonal; Caseins; Cell Differentiation; Membrane Proteins; Mutation; Myxococcus xanthus; Phosphorylation; Phosphotyrosine; Prokaryotic Cells; Protein Hydrolysates; Protein-Tyrosine Kinases; Tyrosine | 1996 |
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.
Topics: Animals; Aorta; Cattle; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Isoflavones; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Stress, Mechanical; Tissue Distribution; Tyrosine; Tyrphostins | 1996 |
Detection of EGF-induced EGF receptor degradation and tyrosine phosphorylation in intact cells.
Topics: Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Liver; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Time Factors; Tyrosine | 1996 |
Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines.
Topics: Bombesin; Bradykinin; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrins; Humans; Kinetics; Lung Neoplasms; Neuropeptides; Neurotensin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1996 |
Regulation of tyrosine phosphorylation and protein tyrosine phosphatases during oligodendrocyte differentiation.
Topics: Animals; Cell Differentiation; Cytosol; Nerve Tissue Proteins; Oligodendroglia; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Subcellular Fractions; Tyrosine; Vanadates | 1996 |
A possible tyrosine phosphorylation of phytochrome.
Topics: Antibodies, Monoclonal; Antibody Specificity; Avena; Blotting, Western; Darkness; Light; Phosphorylation; Phosphotyrosine; Phytochrome; Tyrosine | 1996 |
Effects of mitogens on androgen receptor-mediated transactivation.
Topics: Animals; Cell Line; COS Cells; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; HeLa Cells; Insulin-Like Growth Factor I; Intracellular Membranes; Isoflavones; Ligands; Mitogens; Phosphorylation; Phosphotyrosine; Rats; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Tyrosine; Vanadates | 1996 |
Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60c-src kinase.
Topics: Electrophoresis, Polyacrylamide Gel; Enzyme Activation; ErbB Receptors; GTPase-Activating Proteins; Histones; Humans; Kinetics; Magnesium; Manganese; Ovalbumin; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyglutamic Acid; Polylysine; Proteins; ras GTPase-Activating Proteins; src-Family Kinases; Trypsin; Tumor Cells, Cultured; Tyrosine | 1996 |
Tyrosine phosphorylation blocks tyrosine free radical formation and, hence, the hormonogenic iodination reaction.
Topics: Dimerization; Free Radicals; Iodine; Phosphorylation; Phosphotyrosine; Thyroglobulin; Tyrosine | 1996 |
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Transfection; Tyrosine; Umbilical Veins | 1996 |
Participation of 125 kDa tyrosine-phosphorylated protein in phagocytosis of Acanthamoeba cells.
Topics: Acanthamoeba; Animals; Phagocytosis; Phosphorylation; Phosphotyrosine; Protozoan Proteins; Tyrosine | 1996 |
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo.
Topics: Animals; Cell Fractionation; Cell Membrane; Endosomes; Enzyme Activation; Enzyme Inhibitors; Female; Insulin; Kinetics; Liver; Macromolecular Substances; Organometallic Compounds; Phenanthrolines; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine | 1996 |
Characterization of novel mutations at the Schizosaccharomyces pombe cdc2 regulatory phosphorylation site, tyrosine 15.
Topics: CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Fungal Proteins; Genetic Complementation Test; Microtubules; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Tyrosine | 1996 |
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1.
Topics: Animals; Aorta; Cattle; Caveolin 1; Caveolins; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Kinetics; Membrane Proteins; Microcirculation; Nitric Oxide Synthase; Phosphates; Phosphorylation; Phosphotyrosine; Protein Binding; Pulmonary Circulation; Tyrosine; Vanadates | 1996 |
Tyrosine phosphorylation and subcellular redistribution of p125 ras guanosine triphosphatase-activating protein in human neutrophils stimulated with FMLP.
Topics: Cell Membrane; Concanavalin A; Cytosol; GTPase-Activating Proteins; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Respiratory Burst; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction.
Topics: Acetylcholine; Analysis of Variance; Animals; Blotting, Western; Cytoskeletal Proteins; Dogs; Genistein; In Vitro Techniques; Isoflavones; Isometric Contraction; Kinetics; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Serotonin; Trachea; Tyrosine | 1996 |
Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPO-mediated myeloid cell proliferation.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; GRB2 Adaptor Protein; Humans; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; src Homology Domains; Stem Cell Factor; Thrombopoietin; Tyrosine; Ubiquitin-Protein Ligases | 1996 |
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Line; Electrophoresis, Gel, Two-Dimensional; ErbB Receptors; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Rabbits; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Threonine; Tyrosine | 1996 |
Tyrosine phosphorylation and activation of pp60c-src and pp125FAK in bradykinin-stimulated fibroblasts.
Topics: Bradykinin; Cell Adhesion Molecules; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Time Factors; Tyrosine | 1996 |
Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Enzyme Inhibitors; Golgi Apparatus; GTP-Binding Proteins; Humans; Membrane Proteins; Molecular Sequence Data; Nitriles; Phosphorylation; Phosphotyrosine; Pituitary Gland; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Tyrosine; Tyrphostins; Vanadates; Zinc | 1996 |
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism.
Topics: Amyloid beta-Protein Precursor; Blotting, Western; Calcium; Carbachol; Cells, Cultured; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Indoles; Ionomycin; Isoflavones; Kidney; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, Muscarinic; Signal Transduction; Tyrosine | 1996 |
Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinases; GRB2 Adaptor Protein; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine | 1997 |
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1.
Topics: Collagen; Enzyme Inhibitors; Enzyme Precursors; Integrins; Intracellular Signaling Peptides and Proteins; Isoenzymes; Magnesium; Peptides; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Collagen; Syk Kinase; Type C Phospholipases; Tyrosine | 1997 |
Peroxynitrite-induced tyrosine nitration and phosphorylation in human platelets.
Topics: Blood Platelets; Blood Proteins; Humans; Nitrates; P-Selectin; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Serotonin; Thrombin; Tyrosine | 1997 |
Ras GTPase-activating protein-associated p62 is a major v-Src-SH3-binding protein.
Topics: 3T3 Cells; Animals; Detergents; DNA-Binding Proteins; Glutathione Transferase; Humans; Immunoblotting; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Recombinant Fusion Proteins; RNA-Binding Proteins; Solubility; src Homology Domains; src-Family Kinases; Tyrosine | 1997 |
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mice; Molecular Sequence Data; Phospholipase C gamma; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; src Homology Domains; Syk Kinase; Type C Phospholipases; Tyrosine | 1997 |
Constitutive tyrosine phosphorylation of the vav proto-oncogene product in MRL/Mp-lpr/lpr mice.
Topics: Animals; Cell Cycle Proteins; Female; Lymphocyte Activation; Mice; Mice, Inbred MRL lpr; Phosphorylation; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Species Specificity; Spleen; T-Lymphocytes; Tyrosine | 1997 |
Endogenous autoinhibitors regulate changes in actin tyrosine phosphorylation during Dictyostelium spore germination.
Topics: Actins; Animals; Dictyostelium; Phosphorylation; Phosphotyrosine; Spores, Fungal; Tyrosine | 1997 |
Total inhibition of phospholipase C and phosphatidylinositol 3-kinase by okadaic acid in thrombin-stimulated platelets.
Topics: Blood Platelets; Blood Proteins; Enzyme Inhibitors; Fibrinogen; Humans; Mitogens; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Glycoprotein GPIIb-IIIa Complex; Precipitin Tests; Thrombin; Type C Phospholipases; Tyrosine | 1997 |
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130.
Topics: Animals; B-Lymphocytes; Binding Sites; Cell Line; Chickens; Cloning, Molecular; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Kinetics; Lymphocyte Activation; Mice; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Recombinant Proteins; Syk Kinase; Transfection; Tyrosine | 1997 |
High-performance liquid chromatography on-line derivative spectroscopy for the characterization of peptides with aromatic amino acid residues.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Mathematics; Peptide Fragments; Phenylalanine; Phosphotyrosine; Spectrophotometry, Ultraviolet; Tryptophan; Tyrosine | 1997 |
In vitro binding and phosphorylation of insulin receptor substrate 1 by the insulin receptor. Role of interactions mediated by the phosphotyrosine-binding domain and the pleckstrin-homology domain.
Topics: Animals; Binding Sites; Blood Proteins; CHO Cells; Cricetinae; Insulin Receptor Substrate Proteins; Kinetics; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Structure-Activity Relationship; Tyrosine | 1997 |
Insulin stimulation of human adipocytes activates the kinase of only a fraction of the insulin receptors.
Topics: Adipocytes; Animals; Antibodies; Cell-Free System; Enzyme Activation; Humans; Insulin; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Solubility; Swine; Tyrosine | 1997 |
Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cricetinae; DNA; Mesocricetus; Mice; Molecular Sequence Data; Mutation; Phenotype; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Precancerous Conditions; Proto-Oncogene Proteins pp60(c-src); Transfection; Tyrosine | 1997 |
The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
Topics: Adenosine Triphosphate; Animals; Baculoviridae; Cloning, Molecular; Escherichia coli; Humans; Luciferases; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Serine; Spodoptera; Threonine; Transfection; Tyrosine | 1997 |
Tyrosine phosphorylation of nicotinic acetylcholine receptor mediates Grb2 binding.
Topics: Adaptor Proteins, Signal Transducing; Animals; Electric Organ; GRB2 Adaptor Protein; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proteins; Receptors, Nicotinic; Recombinant Fusion Proteins; src Homology Domains; Synaptic Membranes; Tissue Distribution; Torpedo; Tyrosine | 1997 |
Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells.
Topics: Animals; Binding Sites; Cattle; Cell Adhesion; Cells, Cultured; Humans; Intercellular Junctions; Intracellular Signaling Peptides and Proteins; Molecular Weight; Muscle, Smooth, Vascular; Peptide Fragments; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine | 1997 |
Tyrosine phosphorylation is required for ehrlichial internalization and replication in P388D1 cells.
Topics: Animals; Benzoquinones; Ehrlichia; Genistein; Glutamine; Isoflavones; Lactams, Macrocyclic; Leukemia P388; Macrophages; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1997 |
Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Specificity; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Humans; Mice; Molecular Sequence Data; Phenotype; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 1997 |
Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence.
Topics: beta Catenin; Breast; Cadherins; Cell Count; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Enzyme Induction; Epithelium; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Trans-Activators; Tyrosine | 1997 |
The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Binding Sites; Cell Transformation, Neoplastic; GRB2 Adaptor Protein; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1997 |
Tyrosine phosphorylation in contraction of opossum esophageal longitudinal muscle in response to SNP.
Topics: Animals; Benzylidene Compounds; Carbachol; Cyclic GMP; Enzyme Inhibitors; Genistein; Isoflavones; Isometric Contraction; Models, Biological; Muscle Relaxation; Muscle, Smooth; Nitriles; Nitroprusside; Opossums; Phosphorylation; Phosphotyrosine; Potassium Chloride; Protein-Tyrosine Kinases; Trachea; Tyrosine; Tyrphostins | 1997 |
Increased level of phosphotyrosine in human dendritic cells under stimulation with contact sensitizers but not irritants.
Topics: Animals; Dendritic Cells; Dermatitis, Contact; Haptens; Humans; In Vitro Techniques; Irritants; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Thiazoles; Tyrosine | 1997 |
Intratumoral heterogeneity for and epigenetic modulation of mdr-1 expression in murine melanoma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Count; Cell Cycle; Cell Division; Drug Resistance, Multiple; Female; Gene Expression; Immunohistochemistry; In Situ Hybridization; Leucine; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Tritium; Tumor Cells, Cultured; Tyrosine | 1997 |
Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5.
Topics: Animals; Binding Sites; Cell Line; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; Human Growth Hormone; Humans; Janus Kinase 2; Milk Proteins; Models, Structural; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Recombinant Fusion Proteins; Recombinant Proteins; STAT5 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 1997 |
Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Conserved Sequence; Enzyme Activation; Humans; Jurkat Cells; Kinetics; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Point Mutation; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Recombinant Proteins; Spodoptera; src-Family Kinases; T-Lymphocytes; Transfection; Tyrosine; Vanadates | 1997 |
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Binding Sites; Biological Transport; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Fragments; Phosphotyrosine; Protein Binding; Protein Conformation; Tyrosine | 1997 |
Thy-1 and AvGp50 signal transduction complex in the avian nervous system: c-Fyn and G alpha i protein association and activation of signalling pathways.
Topics: Animals; Antibodies, Monoclonal; Cell Adhesion Molecules, Neuronal; Cell Membrane; Chick Embryo; Cholesterol; Detergents; Glycosylphosphatidylinositols; GTP-Binding Protein alpha Subunits, Gi-Go; Leukocyte L1 Antigen Complex; Membrane Glycoproteins; Membrane Lipids; Neural Cell Adhesion Molecule L1; Neural Cell Adhesion Molecules; Neurites; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Prosencephalon; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Signal Transduction; Subcellular Fractions; Thy-1 Antigens; Tubulin; Tyrosine | 1997 |
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Line; DNA Primers; Humans; Insulin Receptor Substrate Proteins; Kidney; Kinetics; Liver; Mice; Mice, Obese; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Kinase C; Receptor, Insulin; Recombinant Proteins; Sequence Tagged Sites; Serine; Transfection; Tyrosine | 1997 |
Oxidant-induced disruption of intestinal epithelial barrier function: role of protein tyrosine phosphorylation.
Topics: Arsenicals; Bumetanide; Calcium; Cell Line; Cell Membrane Permeability; Electric Conductivity; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Intestinal Mucosa; Kinetics; Mannitol; Membrane Potentials; Octoxynol; Oxidants; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine; Vanadates | 1997 |
Tyrosine phosphorylation of the herpes simplex virus type 1 regulatory protein ICP22 and a cellular protein which shares antigenic determinants with ICP22.
Topics: 3T3 Cells; Animals; Antibodies, Viral; Chlorocebus aethiops; Epitopes; HeLa Cells; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Immediate-Early Proteins; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rabbits; Recombinant Fusion Proteins; Tyrosine; Vero Cells; Viral Proteins; Viral Regulatory and Accessory Proteins | 1997 |
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Alanine; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Insulin-Like Growth Factor I; Isoenzymes; Mutagenesis, Site-Directed; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Recombinant Proteins; Serine; Transfection; Tyrosine | 1997 |
Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells.
Topics: Actins; Animals; Antigens, CD; beta Catenin; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; CHO Cells; Cricetinae; Cytoskeletal Proteins; Cytoskeleton; Delta Catenin; Desmoplakins; Desmosomes; Endothelium, Vascular; gamma Catenin; Gene Expression; Humans; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Trans-Activators; Transfection; Tyrosine; Umbilical Veins | 1997 |
Phosphorylation of Tyr7, Tyr10, and Ser27 of alpha-chain in H+,K(+)-ATPase by intrinsic and extrinsic kinases.
Topics: Animals; Cholic Acids; Detergents; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Kinetics; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Serine; Swine; Tyrosine | 1997 |
PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; DNA Mutational Analysis; Enzyme Activation; Humans; Mice; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Signal Transduction; src-Family Kinases; Tyrosine | 1997 |
The axonemal microtubules of the Chlamydomonas flagellum differ in tubulin isoform content.
Topics: Animals; Chlamydomonas reinhardtii; Flagella; Isomerism; Microtubules; Phosphotyrosine; Protein Processing, Post-Translational; Tubulin; Tyrosine | 1998 |
Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p.
Topics: Adenosine Triphosphatases; Amnion; Cell Cycle; Cell Cycle Proteins; Cell Line; Fungal Proteins; Humans; Mutagenesis, Insertional; Nuclear Localization Signals; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion; Tyrosine; Valosin Containing Protein | 1998 |
Tyrosyl-phosphorylated proteins are involved in regulation of meiosis in the rat egg.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Egg Proteins; Fertilization; Ionomycin; Meiosis; Ovum; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Tyrosine | 1998 |
A fluorescence polarization competition immunoassay for tyrosine kinases.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Antibodies; Fluorescein; Fluorescence Polarization Immunoassay; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphotyrosine; Protein-Tyrosine Kinases; Reproducibility of Results; Tyrosine | 1998 |
Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.
Topics: Adaptor Proteins, Signal Transducing; GRB2 Adaptor Protein; Humans; Interleukin-2; Killer Cells, Natural; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; src Homology Domains; T-Lymphocytes; Tyrosine; Ubiquitin-Protein Ligases | 1998 |
Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.
Topics: Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; src Homology Domains; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Antibodies against EMC virus RNA-VPg recognize Tyr-(5'P-->O)-pU and immunostain infected cells.
Topics: Animals; Antibodies; CHO Cells; Cricetinae; Encephalomyocarditis virus; Fluorescent Antibody Technique; Immunoblotting; Oligoribonucleotides; Phosphotyrosine; RNA, Viral; Serum Albumin; Tyrosine; Viral Core Proteins; Viral Proteins | 1998 |
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; COS Cells; Cytoplasm; Endoplasmic Reticulum; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Substrate Specificity; Tyrosine | 1998 |
The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway.
Topics: Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Carcinoma, Squamous Cell; Enzyme Activation; Enzyme Induction; Genistein; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Phosphotyrosine; Protein Kinase C; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1998 |
Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.
Topics: Animals; COS Cells; Cytoplasm; Genes, Dominant; Humans; Interleukin-13; Interleukin-4; Janus Kinase 1; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-4; Recombinant Proteins; STAT6 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 1998 |
Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.
Topics: Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cricetinae; Cricetulus; Cytoskeleton; Fibroblasts; Isoenzymes; Mitogen-Activated Protein Kinase 1; Morphogenesis; Mutation; Phospholipase C gamma; Phosphotyrosine; Type C Phospholipases; Tyrosine | 1998 |
Divergent signal transduction responses to infection with attaching and effacing Escherichia coli.
Topics: Adhesins, Bacterial; Bacterial Outer Membrane Proteins; Carrier Proteins; Cell Line; Cytoskeletal Proteins; Diarrhea; Escherichia coli O157; Escherichia coli Proteins; Humans; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1998 |
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
Topics: Cloning, Molecular; Enzyme Precursors; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; Recombinant Proteins; Retroviridae Proteins, Oncogenic; Saccharomyces cerevisiae; Substrate Specificity; Syk Kinase; Transfection; Tyrosine | 1998 |
A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor alpha-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Conserved Sequence; DNA-Binding Proteins; Humans; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Lymphoma, B-Cell; Macromolecular Substances; Mice; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphotyrosine; Point Mutation; Receptor, Insulin; Receptors, IgE; Receptors, Interleukin-4; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; src Homology Domains; STAT4 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells.
Topics: Actins; Animals; Cells, Cultured; Colchicine; Cortactin; Cytochalasin D; Microfilament Proteins; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Kinases; Rabbits; Tyrosine | 1998 |
Hormonal regulation of focal adhesions in bovine adrenocortical cells: induction of paxillin dephosphorylation by adrenocorticotropic hormone.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cattle; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Colforsin; CSK Tyrosine-Protein Kinase; Cyclic AMP; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunohistochemistry; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine; Vanadates | 1998 |
Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Binding Sites; DNA; Humans; Immunosorbent Techniques; Insulin; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, Insulin; Regulatory Sequences, Nucleic Acid; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Transfection; Tyrosine | 1998 |
Increased tyrosine phosphorylation of band 3 in hemoglobinopathies.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Anion Exchange Protein 1, Erythrocyte; Antibodies; beta-Thalassemia; Erythrocyte Count; Erythrocytes; Hemoglobin SC Disease; Hemoglobinopathies; Humans; Immunoblotting; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Reticulocytes; Tyrosine; Vanadates | 1998 |
The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenylate Cyclase Toxin; Animals; Calcitonin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Enzyme Activation; Enzyme Inhibitors; GRB2 Adaptor Protein; GTP-Binding Proteins; Ionomycin; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proteins; Rabbits; Receptors, Calcitonin; Shc Signaling Adaptor Proteins; Tyrosine; Virulence Factors, Bordetella | 1998 |
Flow cytometric analysis of protein phosphorylation in the hematopoetic system.
Topics: Acute Disease; Adult; Flow Cytometry; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Lymphocytes; Monocytes; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Tyrosine | 1998 |
Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Microinjections; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Stress, Mechanical; Tyrosine | 1998 |
Characterization of a mobile Stat6 activation motif in the human IL-4 receptor.
Topics: Adjuvants, Immunologic; Amino Acids; Animals; Base Sequence; Dose-Response Relationship, Immunologic; Gene Expression Regulation; Humans; Interleukin-4; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphotyrosine; Protein Binding; Receptors, IgE; Receptors, Interleukin-4; Sequence Deletion; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Tyrosine | 1998 |
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Cell Adhesion Molecules; Chromones; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers.
Topics: beta Catenin; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Humans; Immunohistochemistry; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Staining and Labeling; Stomach Neoplasms; Trans-Activators; Tyrosine | 1998 |
EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Diglycerides; DNA; Enzyme Activation; ErbB Receptors; Humans; Hydrogen Peroxide; Isoenzymes; Kinetics; Oxidation-Reduction; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1998 |
Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; Enzyme Activation; Fibroblasts; Insulin; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Proteins; Rats; Receptor, Insulin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transfection; Tyrosine | 1998 |
Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I.
Topics: Binding Sites; Consensus Sequence; Enzyme Activation; Humans; Interleukin-1; NF-kappa B; Osteosarcoma; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Receptors, Interleukin-1; Receptors, Interleukin-1 Type I; src Homology Domains; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Protein kinase C-delta activation and tyrosine phosphorylation in platelets.
Topics: Antibodies, Monoclonal; Blood Platelets; Cell Fractionation; Enzyme Activation; Fibrinogen; Humans; In Vitro Techniques; Isoenzymes; Phosphorylation; Phosphotyrosine; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Kinase C-delta; Thrombin; Tyrosine | 1998 |
Bradykinin-induced tyrosine phosphorylation of proteins in cultured human keratinocytes.
Topics: Antibodies, Monoclonal; Bradykinin; Humans; Keratinocytes; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine | 1998 |
Abnormal pattern of tyrosine phosphorylation in unstimulated peripheral blood T lymphocytes from patients with systemic lupus erythematosus.
Topics: Adolescent; Adult; Blood Proteins; Cells, Cultured; Child; Electrophoresis, Polyacrylamide Gel; Female; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1998 |
Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).
Topics: Amino Acid Sequence; Binding Sites; Drug Design; Enzyme Inhibitors; ErbB Receptors; Indicators and Reagents; Kinetics; Peptide Fragments; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tyrosine | 1998 |
Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Dimethyl Sulfoxide; Estradiol; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Tyrosine | 1998 |
Concanavalin A modulates tyrosine phosphorylation and activation of a type II phosphatidylinositol 4-kinase in rat splenic lymphocytes.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antibodies; Concanavalin A; Enzyme Activation; Enzyme Inhibitors; Genistein; Lymphocyte Activation; Lymphocytes; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Rabbits; Rats; Rats, Wistar; Spleen; Tyrosine | 1998 |
Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.
Topics: Animals; Binding Sites; Drosophila; Drosophila Proteins; Insect Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Proteins; ras GTPase-Activating Proteins; Receptor Protein-Tyrosine Kinases; Repressor Proteins; Signal Transduction; Substrate Specificity; Tyrosine | 1998 |
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Macromolecular Substances; Models, Molecular; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Peptides, Cyclic; Phosphotyrosine; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tyrosine | 1998 |
Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association.
Topics: Adaptor Proteins, Signal Transducing; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Humans; Jurkat Cells; Mutagenesis, Site-Directed; NFATC Transcription Factors; Nuclear Proteins; Oncogene Protein v-cbl; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Mas; Retroviridae Proteins, Oncogenic; Transcription Factor AP-1; Transcription Factors; Tyrosine | 1999 |
Detection of increased tyrosine phosphorylation in murine Langerhans cells after stimulation with contact sensitizers.
Topics: Animals; Blotting, Western; Cell Line; Female; Flow Cytometry; Langerhans Cells; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Phosphotyrosine; Picryl Chloride; Signal Transduction; Tyrosine | 1999 |
Developmental regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor in Torpedo electrocyte.
Topics: Aging; Animals; Blotting, Western; Electric Organ; Fluorescent Antibody Technique; Muscle Proteins; Phosphorylation; Phosphotyrosine; Receptors, Nicotinic; Subcellular Fractions; Tissue Distribution; Torpedo; Tyrosine | 1999 |
Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus.
Topics: Animals; Antibody Specificity; Hippocampus; Hypoglycemic Agents; Insulin; Male; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tyrosine | 1999 |
Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.
Topics: Amino Acid Substitution; Animals; Cell Membrane; COS Cells; Cytoplasm; Escherichia coli; Janus Kinase 2; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Receptors, Eph Family; Receptors, Interleukin; Receptors, Interleukin-12; Recombinant Fusion Proteins; Sequence Deletion; Transfection; Tyrosine | 1999 |
Adhesion-induced intracellular signalling in endothelial cells depends on the nature of the matrix.
Topics: Actins; Cell Adhesion; Cell Line; Endothelium, Vascular; Extracellular Matrix; Fibronectins; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; Signal Transduction; Thrombospondin 1; Time Factors; Tyrosine; Vinculin | 1999 |
Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway.
Topics: Animals; Carbon Radioisotopes; Cattle; Endothelium, Vascular; Endotoxins; Enzyme Inhibitors; Extracellular Matrix Proteins; Gap Junctions; Intercellular Junctions; Phosphorylation; Phosphotyrosine; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Serum Albumin, Bovine; Thrombospondin 1; Transforming Growth Factor beta; Tyrosine | 1999 |
Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.
Topics: Animals; Catalytic Domain; COS Cells; Eukaryotic Initiation Factor-2; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Prenylation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rap GTP-Binding Proteins; ras Guanine Nucleotide Exchange Factors; src Homology Domains; Structure-Activity Relationship; Tyrosine | 1999 |
Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937.
Topics: Enzyme Activation; Humans; Interleukin-17; Killer Cells, Natural; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Signal Transduction; Tyrosine; U937 Cells | 1999 |
Thrombospondin-1 induces activation of focal adhesion kinase in vascular smooth muscle cells.
Topics: Animals; Cattle; Cell Adhesion Molecules; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Immunoblotting; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Thrombospondin 1; Tyrosine | 1999 |
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.
Topics: Arsenicals; Cell Nucleus; Copper; Diamide; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; Hydrogen Peroxide; Iron; Lymphocytes; Oxidative Stress; Phenanthrolines; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein Tyrosine Phosphatases; Reactive Oxygen Species; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Vanadates | 1999 |
Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes: its relationship to cytoskeletal actin organization.
Topics: Actins; Animals; Astrocytes; Calcium; Cells, Cultured; Cytoskeleton; Endothelin-1; Endothelin-3; Mice; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Proteins; Rabbits; Rats; Rats, Wistar; Tyrosine; Virulence Factors, Bordetella | 1999 |
SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.
Topics: Amino Acid Sequence; Animals; Becaplermin; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Enzyme Activation; Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-sis; ras Proteins; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Swine; Transfection; Tyrosine | 1999 |
Tyrosine phosphorylation in peripheral T cells of kidney transplant recipients: analyses of baseline levels and response to T cell receptor stimulation.
Topics: Adult; Aged; Antibodies, Monoclonal; CD3 Complex; Female; Humans; Kidney Transplantation; Male; Middle Aged; Phosphorylation; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocytes; Tyrosine | 1999 |
Phosphotyrosine of macrophage by low-density lipoproteins from hemodialysis patients.
Topics: Enzyme Inhibitors; Genistein; Humans; Immunoblotting; Lipoproteins, LDL; Macrophages; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Renal Dialysis; Tyrosine | 1999 |
Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Enzyme Activation; Genistein; Insulin; Insulin Antagonists; Kidney Tubules, Proximal; Male; Opossums; Ouabain; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Transfection; Tyrosine; Vanadates | 1999 |
Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice.
Topics: Animals; Cattle; Growth Hormone; Insulin; Insulin Receptor Substrate Proteins; Mice; Mice, Transgenic; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Isoforms; Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1999 |
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3.
Topics: Amino Acid Sequence; Casein Kinase II; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptide Fragments; Peptidylprolyl Isomerase; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Serine; Substrate Specificity; Threonine; Tyrosine | 1999 |
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Cisplatin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Phosphorylation; Phosphotyrosine; Polypharmacy; Quinazolines; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrosine | 1999 |
Tyrosines 60, 64, and 101 of Epstein-Barr virus LMP2A are not essential for blocking B cell signal transduction.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; B-Lymphocytes; Calcium; Calcium Signaling; Callithrix; Cell Line; Cell Line, Transformed; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Trans-Activators; Tyrosine; Viral Matrix Proteins; Viral Proteins | 1999 |
RhoA inactivation enhances endothelial barrier function.
Topics: Actins; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; beta Catenin; Biological Transport; Botulinum Toxins; Cattle; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Fluorescent Antibody Technique; Hemostatics; Image Processing, Computer-Assisted; Intercellular Junctions; Myosins; Paxillin; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pulmonary Artery; rhoA GTP-Binding Protein; Stress, Mechanical; Thrombin; Trans-Activators; Tyrosine | 1999 |
Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain.
Topics: Animals; Binding Sites; Chickens; DNA-Binding Proteins; Enzyme Precursors; ets-Domain Protein Elk-1; Intracellular Signaling Peptides and Proteins; NFATC Transcription Factors; Nuclear Proteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptors, Antigen, B-Cell; Signal Transduction; Syk Kinase; Transcription Factors; Tyrosine; Ubiquitin-Protein Ligases | 1999 |
Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; B-Lymphocytes; Binding Sites; GRB2 Adaptor Protein; Humans; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; Receptors, Antigen, B-Cell; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 1999 |
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Topics: Animals; Cell Adhesion; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibroblasts; Fibronectins; Isoenzymes; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Rats; Type C Phospholipases; Tyrosine | 1999 |
Developmental expression of insulin receptor substrate-2 during dimethylsulfoxide-induced differentiation of human HL-60 cells.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Dose-Response Relationship, Immunologic; Enzyme Activation; Granulocytes; HL-60 Cells; Humans; Immune Sera; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Receptor, IGF Type 1; Receptor, Insulin; RNA, Messenger; Substrate Specificity; Tyrosine | 2000 |
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Affinity Labels; Amino Acid Sequence; Antigens, CD; Carrier Proteins; Glycoproteins; Humans; Immunoglobulins; Intracellular Signaling Peptides and Proteins; Ligands; Lymphoproliferative Disorders; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphotyrosine; Polymerase Chain Reaction; Protein Binding; Proteins; Receptors, Cell Surface; Shc Signaling Adaptor Proteins; Signaling Lymphocytic Activation Molecule Associated Protein; Signaling Lymphocytic Activation Molecule Family Member 1; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 1999 |
The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling.
Topics: Agrin; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Phosphorylation; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Cholinergic; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2000 |
Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase.
Topics: Animals; Binding Sites; Brain Ischemia; Gerbillinae; Mice; Mice, Mutant Strains; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Prosencephalon; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Tyrosine | 1999 |
Involvement of the membrane distal catalytic domain in pervanadate-induced tyrosine phosphorylation of receptor protein-tyrosine phosphatase alpha.
Topics: Catalytic Domain; Cell Membrane; Enzyme Inhibitors; Humans; Mutagenesis, Site-Directed; Neuroectodermal Tumors, Primitive, Peripheral; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates | 2000 |
Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Base Sequence; CCAAT-Enhancer-Binding Proteins; Cell Line; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgE; Recombinant Proteins; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Structure, Secondary; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tyrosine | 2000 |
The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Enzyme Activation; Erythropoietin; GRB2 Adaptor Protein; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Erythropoietin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 2000 |
Tyrosine phosphorylation of myelin P(0) and its implication in signal transduction.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Brain; Cell Line; Cloning, Molecular; Consensus Sequence; Humans; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Myelin P0 Protein; Neurilemmoma; Phenylalanine; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Sequence Alignment; Signal Transduction; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates | 2000 |
Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation.
Topics: DNA, Fungal; Fungal Proteins; Gene Deletion; Gene Expression; Genes, Essential; Genes, Fungal; Glycogen Synthase Kinase 3; Intracellular Signaling Peptides and Proteins; Meiosis; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spores, Fungal; Tyrosine | 2000 |
Regulation of microglial tyrosine phosphorylation in response to neuronal injury.
Topics: Animals; Anterior Horn Cells; Benzoquinones; Denervation; Enzyme Inhibitors; Ganglia, Spinal; Lactams, Macrocyclic; Microglia; Nerve Degeneration; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Ricin; Rifabutin; Sciatic Nerve; Tyrosine | 2000 |
Phosphorylation of a Src kinase at the autophosphorylation site in the absence of Src kinase activity.
Topics: Animals; Binding Sites; Cell Line; Humans; Hydrogen Peroxide; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Peptide Mapping; Phosphorylation; Phosphotyrosine; src-Family Kinases; Tyrosine | 2000 |
Adherence of platelets under flow conditions results in specific phosphorylation of proteins at tyrosine residues.
Topics: Blotting, Western; Cells, Cultured; Collagen; Endothelium, Vascular; Extracellular Matrix Proteins; Humans; Phosphorylation; Phosphotyrosine; Platelet Adhesiveness; Pulsatile Flow; Signal Transduction; Tyrosine; Umbilical Veins | 2000 |
Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin.
Topics: Animals; Azepines; Cadherins; Cytoskeleton; Dextrans; Enzyme Inhibitors; Epithelium; Glucose; Hypotension; Intestinal Mucosa; Intestines; Leukocytosis; Male; Permeability; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tyrosine; Tyrphostins | 2000 |
Autocrine human growth hormone enhancement of human mammary carcinoma cell spreading is Jak2 dependent.
Topics: Actins; Autocrine Communication; Breast Neoplasms; Carcinoma; Cell Adhesion; Enzyme Inhibitors; Female; Growth Hormone; Hormone Antagonists; Human Growth Hormone; Humans; Janus Kinase 2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Recombinant Proteins; Tissue Distribution; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration.
Topics: Amidohydrolases; Androstadienes; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Chelating Agents; Cross-Linking Reagents; Cytochalasin B; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Indoles; Mice; Mice, Inbred BALB C; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Signal Transduction; Time Factors; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma.
Topics: Adenocarcinoma; Blotting, Western; Chromatography, High Pressure Liquid; Cortactin; Humans; Microfilament Proteins; Nitrates; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein Folding; Proto-Oncogene Proteins pp60(c-src); Tumor Cells, Cultured; Tyrosine | 2000 |
Mutational investigation of the specificity determining region of the Src SH2 domain.
Topics: Amino Acid Substitution; Binding Sites; Calorimetry; Computer Simulation; Consensus Sequence; Lysine; Models, Molecular; Mutation; Peptides; Phosphotyrosine; Protein Binding; src Homology Domains; src-Family Kinases; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Titrimetry; Tyrosine | 2000 |
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.
Topics: Biological Transport; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase; Humans; Insulin; Insulin Receptor Substrate Proteins; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Time Factors; Tyrosine | 2000 |
Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Culture Media; Cytokines; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Inflammation Mediators; Oncostatin M; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Time Factors; Tumor Cells, Cultured; Tyrosine | 2000 |
BDNF-Induced potentiation of spontaneous twitching in innervated myocytes requires calcium release from intracellular stores.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Cadmium; Calcium; Calcium Channels; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Indoles; Motor Neurons; Muscle Contraction; Muscle Fibers, Skeletal; Oocytes; PC12 Cells; Phosphodiesterase Inhibitors; Phosphorylation; Phosphotyrosine; Pyrrolidinones; Rats; Receptor, trkB; Synapses; Thapsigargin; Type C Phospholipases; Tyrosine; Xenopus | 2000 |
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
Topics: Actins; Adult; Cell Adhesion; Cytoskeletal Proteins; DNA-Binding Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Human Growth Hormone; Humans; Janus Kinase 2; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Potentiation of neuronal L calcium channels by IGF-1 requires phosphorylation of the alpha1 subunit on a specific tyrosine residue.
Topics: Animals; Calcium Channel Agonists; Calcium Channels, L-Type; Catalysis; Cell Line; Genetic Vectors; Immunoblotting; Insulin-Like Growth Factor I; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphorus Radioisotopes; Phosphotyrosine; Precipitin Tests; Proto-Oncogene Proteins pp60(c-src); Rats; src-Family Kinases; Stimulation, Chemical; Tyrosine | 2000 |
Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Binding Sites; DNA-Binding Proteins; Human Growth Hormone; Humans; Janus Kinase 2; Kinetics; Mice; Milk Proteins; Mutagenesis, Site-Directed; Phenylalanine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cells, Cultured; Dimerization; DNA-Binding Proteins; Humans; Interferon-alpha; Interferon-gamma; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Receptor, Interferon alpha-beta; Receptors, Interferon; Receptors, Interleukin-2; Recombinant Fusion Proteins; Recombinant Proteins; STAT1 Transcription Factor; STAT4 Transcription Factor; Structure-Activity Relationship; T-Lymphocytes; Trans-Activators; Transcription, Genetic; Tyrosine | 2000 |
Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Line; Cytokines; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; Genes, myc; Growth Substances; HeLa Cells; Humans; Interleukin-3; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Isoforms; Receptors, Cytokine; Receptors, Growth Factor; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2000 |
Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation.
Topics: Animals; Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Dinoprostone; Humans; In Vitro Techniques; Integrins; Kinetics; Lectins; Lectins, C-Type; Mice; Mice, Inbred C57BL; Phosphorylation; Phosphotyrosine; Platelet Adhesiveness; Platelet Aggregation; Receptors, Collagen; Receptors, IgG; Tyrosine; Viper Venoms; Viperidae | 2001 |
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
Topics: Amino Acid Substitution; Antigens, CD; Antigens, Surface; Binding Sites; Cell Line; Cytoplasm; Desmosomes; Enzyme Inhibitors; Humans; Integrin alpha6; Integrin alpha6beta4; Integrin beta4; Integrins; Phenylalanine; Phosphopeptides; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrosine; Vanadates | 2001 |
Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation.
Topics: Actins; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cattle; Cell Adhesion Molecules; Cell Communication; Cell Line; Electric Impedance; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Mitogen-Activated Protein Kinases; Peroxides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Vanadates | 2000 |
Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases.
Topics: Actins; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Line, Transformed; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Focal Adhesions; Lactams, Macrocyclic; Mice; Microscopy, Fluorescence; Microtubules; Nocodazole; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Quinones; Rifabutin; src-Family Kinases; Stress Fibers; Tyrosine; Vimentin | 2000 |
In vitro analysis of STAT5 activation by granulocyte-macrophage colony-stimulating factor.
Topics: Animals; Antibodies; Blotting, Western; Cell Membrane; Cell-Free System; Cytosol; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinase 2; Mice; Milk Proteins; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; CD2 Antigens; DNA-Binding Proteins; Humans; Jurkat Cells; Lymphocyte Activation; Molecular Sequence Data; NFATC Transcription Factors; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; T-Lymphocytes; Transcription Factors; Tyrosine; Ubiquitin-Protein Ligases; ZAP-70 Protein-Tyrosine Kinase; Zinc Fingers | 2001 |
Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.
Topics: Adipocytes; Animals; Deoxyglucose; Hyperglycemia; Immunoblotting; Insulin Resistance; Male; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine | 2001 |
Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies; Blotting, Western; Densitometry; Down Syndrome; Female; Humans; Male; Middle Aged; Peptide Fragments; Phosphotyrosine; Pyrrolidonecarboxylic Acid; Tyrosine | 2001 |
Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21(WAF1/Cip1/Sdi1), and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4.
Topics: Animals; Antigens, Differentiation; Blotting, Northern; Carbon Tetrachloride; Cloning, Molecular; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytoplasm; Fibrosis; Galectin 3; Hepatocytes; Immunoblotting; Immunohistochemistry; Liver; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Signal Transduction; Time Factors; Tyrosine | 2001 |
Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases.
Topics: Amino Acid Substitution; Antibodies, Monoclonal; CD3 Complex; CD5 Antigens; Enzyme Activation; Humans; Jurkat Cells; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mutation; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; T-Lymphocytes; Transfection; Tyrosine; Vanadates | 2001 |
Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Angiotensin II; Animals; Calcium; Calcium Signaling; Cell Line; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Activation; Fibroblasts; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; STAT1 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 2001 |
Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode.
Topics: Amino Acid Sequence; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mass Spectrometry; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Signal Transduction; Tyrosine | 2001 |
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Topics: Adipocytes; Animals; Antibodies; Enzyme Activation; Female; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Subcellular Fractions; Tissue Distribution; Tyrosine | 2001 |
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Line; Endocytosis; Endosomes; Enzyme Activation; Epithelial Cells; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Temperature; Time Factors; Tyrosine | 2001 |
Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Casein Kinase II; Emodin; Enzyme Inhibitors; Escherichia coli; Heparin; Kinetics; Models, Molecular; Oligopeptides; Phenylalanine; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Serine-Threonine Kinases; Protein Subunits; Recombinant Proteins; Substrate Specificity; Tyrosine | 2001 |
Nitrotyrosine mimics phosphotyrosine binding to the SH2 domain of the src family tyrosine kinase lyn.
Topics: Amino Acid Sequence; Anion Exchange Protein 1, Erythrocyte; Binding Sites; Enzyme Activation; Humans; In Vitro Techniques; Phosphotyrosine; Recombinant Proteins; src Homology Domains; src-Family Kinases; Tyrosine | 2001 |
Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension.
Topics: Angiotensin II; Animals; Antibody Specificity; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Colforsin; Endothelium, Vascular; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Physical Stimulation; Rats; Rats, Sprague-Dawley; Tyrosine; Tyrphostins; Vanadates; Vasoconstriction; Vasodilator Agents; Verapamil | 2001 |
A repertoire library that allows the selection of synthetic SH2s with altered binding specificities.
Topics: Animals; Binding Sites; Cattle; Kinetics; Ligands; Models, Molecular; Mutagenesis; Peptide Library; Peptides; Phenotype; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Engineering; Protein Structure, Tertiary; src Homology Domains; Surface Plasmon Resonance; Time Factors; Two-Hybrid System Techniques; Tyrosine | 2001 |
Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity.
Topics: Animals; Aplysia; Axons; Cell Adhesion Molecules; Cell Division; Cell Lineage; Cells, Cultured; Cytoskeleton; Enzyme Activation; Phosphorylation; Phosphotyrosine; src-Family Kinases; Traction; Tyrosine | 2001 |
Modulation of nicotinic acetylcholine receptor turnover by tyrosine phosphorylation in rat myotubes.
Topics: Animals; Biotinylation; Bungarotoxins; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Iodine Radioisotopes; Muscle Fibers, Skeletal; Neuromuscular Junction; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tyrosine; Vanadates | 2001 |
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
Topics: Animals; Antigens, CD; Antigens, Surface; Apoptosis Regulatory Proteins; Calcium; Cell Division; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Programmed Cell Death 1 Receptor; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Antigen, B-Cell; Receptors, IgG; Receptors, Immunologic; Receptors, KIR; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine | 2001 |
Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Enzyme Activation; Glycogen; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Isoenzymes; Mitogen-Activated Protein Kinases; Mitosis; Muscle, Skeletal; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reference Values; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrosine | 2001 |
Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation.
Topics: Animals; Antigens; Calcium; Cell Membrane; Cholesterol; Detergents; DNA; DNA Fragmentation; Enzyme Activation; Green Fluorescent Proteins; Immunoblotting; Lipid Metabolism; Luminescent Proteins; Membrane Microdomains; Mice; Microscopy, Confocal; Myristic Acid; Octoxynol; Palmitic Acid; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; Receptors, IgE; Recombinant Proteins; Signal Transduction; Sphingolipids; src-Family Kinases; Structure-Activity Relationship; Time Factors; Transfection; Tyrosine | 2001 |
Systemic biochemical effects of inhaled NO in rats: increased expressions of NOS III, nitrotyrosine-, and phosphotyrosine-immunoreactive proteins in liver and kidney tissues.
Topics: Administration, Inhalation; Animals; Blood Pressure; Blotting, Western; Kidney; Liver; Nitric Oxide; Nitric Oxide Synthase; Phosphotyrosine; Proteins; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells.
Topics: Actins; Bacterial Proteins; cdc42 GTP-Binding Protein; Cell Nucleus; Cytoskeleton; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Salmonella; Salmonella typhimurium; Signal Transduction; Substrate Specificity; Transfection; Tyrosine; Vimentin | 2001 |
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Bacterial Toxins; Binding, Competitive; Cell Survival; Culture Media, Serum-Free; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Exotoxins; Ligands; Molecular Sequence Data; Mutation; Neuregulin-1; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Pseudomonas aeruginosa Exotoxin A; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine; Virulence Factors | 2002 |
Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells.
Topics: Agar; Animals; Antineoplastic Agents; Antioxidants; beta Catenin; Cadherins; Cell Line, Transformed; Cell Movement; Cytoskeletal Proteins; Hydrogen Peroxide; Intestinal Mucosa; Neoplasm Invasiveness; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Oxidative Stress; Phosphotyrosine; Pyrrolidines; Rats; Thiocarbamates; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Cleavage properties of an archaeal site-specific recombinase, the SSV1 integrase.
Topics: Arabinose; Archaea; Base Pair Mismatch; Base Sequence; Binding Sites; Binding, Competitive; Cloning, Molecular; Codon; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fuselloviridae; Integrases; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphotyrosine; Protein Binding; Protein Conformation; Recombinant Proteins; RNA, Transfer; RNA, Transfer, Arg; Spectrometry, Fluorescence; Sulfolobus; Temperature; Time Factors; Tyrosine | 2002 |
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor.
Topics: Binding Sites; Blotting, Western; Cells, Cultured; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Transfection; Tyrosine; Vanadates | 2002 |
Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes.
Topics: Ammonia; Animals; Astrocytes; Cells, Cultured; Dizocilpine Maleate; Drug Synergism; Glutamate-Ammonia Ligase; Glyceraldehyde-3-Phosphate Dehydrogenases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Neurological; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2002 |
Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway.
Topics: Apoptosis; Cell Division; Chlorides; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 5; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine; Zinc Compounds | 2002 |
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Catalysis; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis; Phenylalanine; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Transfection; Tyrosine | 2002 |
Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; B-Lymphocytes; Calcium Signaling; Carrier Proteins; Cell Line; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Syk Kinase; Tyrosine | 2002 |
Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG.
Topics: Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Colony-Forming Units Assay; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Fibroblasts; Fusion Proteins, bcr-abl; Genes, abl; Humans; Interleukin-3; Leukemia, Myeloid; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ets; Rats; Recombinant Proteins; Repressor Proteins; Tumor Cells, Cultured; Tyrosine | 2002 |
Identification of the phosphotyrosine proteome from thrombin activated platelets.
Topics: Blood Platelets; Databases as Topic; Electrophoresis, Gel, Two-Dimensional; Enzyme Precursors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoblotting; Integrins; Intracellular Signaling Peptides and Proteins; Phosphotyrosine; Platelet Activation; Precipitin Tests; Protein-Tyrosine Kinases; Proteome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Syk Kinase; Thrombin; Tyrosine | 2002 |
SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells.
Topics: Animals; Blotting, Western; Cell Differentiation; DNA; DNA, Complementary; Genes, Reporter; Glutathione Transferase; Glycoproteins; Helminth Proteins; Homeobox A10 Proteins; Homeodomain Proteins; Humans; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mutagenesis; NADPH Oxidase 2; NADPH Oxidases; Oligonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plasmids; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Recombinant Fusion Proteins; Time Factors; Transcription, Genetic; Transfection; Tyrosine; U937 Cells | 2002 |
TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Enzyme Activation; GRB2 Adaptor Protein; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutation; Oncogene Proteins, Fusion; p38 Mitogen-Activated Protein Kinases; Phenylalanine; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Proteins; ras Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 2002 |
Dynamic characterization of the molecular events during in vitro epidermal wound healing.
Topics: Cells, Cultured; Cytological Techniques; Epidermal Cells; Epidermis; Humans; In Vitro Techniques; Keratinocytes; MAP Kinase Signaling System; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Software Validation; Transcription Factor AP-1; Tyrosine; Wound Healing | 2002 |
Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.
Topics: Breast Neoplasms; Cell Line, Transformed; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Isoenzymes; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Receptor, EphA2; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates | 2002 |
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding.
Topics: Amino Acid Sequence; Cell Line; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Molecular Sequence Data; Peroxynitrous Acid; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Receptors, Immunologic; Tyrosine | 2002 |
Design and characterization of non-phosphopeptide inhibitors for Src family SH2 domains.
Topics: Caffeic Acids; Dihydroxyphenylalanine; Enzyme-Linked Immunosorbent Assay; Genes, src; Peptides; Phosphotyrosine; src Homology Domains; Tyrosine | 2002 |
Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity.
Topics: Binding Sites; Carrier Proteins; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mechanics; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phosphotyrosine; Protein Binding; Protein Folding; Signaling Lymphocytic Activation Molecule Associated Protein; src Homology Domains; Thermodynamics; Tyrosine | 2002 |
Analysis of tyrosine phosphorylation sites in signaling molecules by a phosphotyrosine-specific immonium ion scanning method.
Topics: Alkylation; Antibodies; Binding Sites; Cell Line; Chromatography, Affinity; Culture Media, Serum-Free; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Imines; Oxidation-Reduction; Peptide Hydrolases; Phosphorylation; Phosphotyrosine; Proteins; Signal Transduction; Silver Staining; Sodium Dodecyl Sulfate; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2002 |
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Breast Neoplasms; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Lymphoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Receptors, Prolactin; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 2003 |
Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2).
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Brain; Detergents; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Lipid Metabolism; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Microdomains; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Octoxynol; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Serine; Signal Transduction; Threonine; Time Factors; Tumor Cells, Cultured; Tyrosine | 2003 |
Localization of tyrosine phosphorylated proteins in human sperm and relation to capacitation and zona pellucida binding.
Topics: Female; Fertilization; Humans; Male; Phosphotyrosine; Proteins; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrosine; Zona Pellucida | 2003 |
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Topics: Alanine; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cytoplasm; Databases as Topic; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Integrin beta Chains; Integrins; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Transfection; Tyrosine | 2003 |
Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability.
Topics: Adherens Junctions; Animals; Antigens, CD; beta Catenin; Cadherins; Capillaries; Carbon Radioisotopes; Cattle; Cell Movement; Chromium Radioisotopes; Cytoskeletal Proteins; Desmoplakins; Endothelium, Vascular; Enzyme Inhibitors; Neovascularization, Physiologic; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Pulmonary Artery; Serum Albumin, Bovine; Trans-Activators; Tyrosine; Vanadates | 2003 |
Mechanism of inhibition of site-specific recombination by the Holliday junction-trapping peptide WKHYNY: insights into phage lambda integrase-mediated strand exchange.
Topics: Attachment Sites, Microbiological; Bacteriophage lambda; Binding Sites; DNA Nucleotidyltransferases; DNA Repair; DNA, Bacterial; Electrophoresis, Gel, Two-Dimensional; Integrases; Kinetics; Models, Genetic; Nucleic Acid Conformation; Phosphotyrosine; Protein Binding; Recombinases; Recombination, Genetic; Tyrosine | 2003 |
Activation of phospholipase D is not mediated by direct phosphorylation on tyrosine residues.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; PC12 Cells; Phospholipase D; Phosphorylation; Phosphotyrosine; Precipitin Tests; Rats; Tyrosine; Vanadates | 2003 |
L-type voltage-gated calcium channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Focal Adhesion Kinase 2; Hippocampus; Immunoblotting; Male; Nifedipine; Phosphorus Isotopes; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion; src-Family Kinases; Tyrosine | 2003 |
Molecular dynamics, free energy, and SPR analyses of the interactions between the SH2 domain of Grb2 and ErbB phosphotyrosyl peptides.
Topics: Adaptor Proteins, Signal Transducing; Computer Simulation; ErbB Receptors; Glutathione Transferase; GRB2 Adaptor Protein; Humans; Kinetics; Ligands; Peptide Fragments; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Folding; Proteins; Receptor, ErbB-4; Recombinant Fusion Proteins; src Homology Domains; Thermodynamics; Tyrosine | 2003 |
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
Topics: Amino Acid Sequence; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphonates; Peptide Fragments; Phosphorylation; Phosphotyrosine; Point Mutation; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; src Homology Domains; Tyrosine | 2003 |
Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion.
Topics: Animals; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Liver Neoplasms; Liver Neoplasms, Experimental; Neoplasm Invasiveness; Phosphatidic Acids; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; rhoA GTP-Binding Protein; Tyrosine | 2003 |
Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.
Topics: Animals; Calcium; Calcium Signaling; Calpain; Cell Adhesion; Cells, Cultured; Cytoskeleton; Growth Cones; Neurons; Phosphorylation; Phosphotyrosine; Pseudopodia; Spinal Cord; src-Family Kinases; Substrate Specificity; Tyrosine; Xenopus | 2003 |
Involvement of the tyrosine phosphorylation on GSH transport in NIH3T3 fibroblasts.
Topics: Animals; Biological Transport; Fibroblasts; Glucose; Glutathione; Hydrogen Peroxide; Mice; Mutation; NIH 3T3 Cells; Oxidants; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrosine; Vanadates | 2003 |
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cricetinae; Growth Hormone; Humans; Ligands; Molecular Sequence Data; Organ Specificity; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, Somatotropin; Signal Transduction; Substrate Specificity; Tyrosine | 2003 |
Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Cell Separation; Cytokines; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erythropoietin; Flow Cytometry; Hematopoietic Stem Cells; Mice; Milk Proteins; Models, Genetic; Mutation; Phosphotyrosine; Proto-Oncogene Proteins c-kit; Receptors, Erythropoietin; Retroviridae; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Analysis of protein tyrosine phosphorylation by nanoelectrospray ionization high-resolution tandem mass spectrometry and tyrosine-targeted product ion scanning.
Topics: Amino Acid Sequence; Cell Line; ErbB Receptors; Humans; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Spectrometry, Mass, Electrospray Ionization; Trypsin; Tyrosine | 2003 |
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Carrier Proteins; Lymphocyte Activation; Mast Cells; Membrane Proteins; Mice; Mice, Knockout; Mutagenesis; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, IgE; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2003 |
Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; COS Cells; Disks Large Homolog 4 Protein; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genetic Vectors; Glutathione Transferase; Green Fluorescent Proteins; Guanylate Kinases; Immunoblotting; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Membrane Proteins; Mice; Models, Genetic; Molecular Sequence Data; Nerve Tissue Proteins; Peptides; Phosphorylation; Phosphotyrosine; Precipitin Tests; Prosencephalon; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; Sequence Homology, Amino Acid; Silver Staining; Tyrosine | 2003 |
TYROSINE-O-PHOSPHATE IN DROSOPHILA.
Topics: Animals; Drosophila; Electrophoresis; Metamorphosis, Biological; Phosphotyrosine; Research; Tyrosine; Ultraviolet Rays | 1964 |
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.
Topics: Actins; Adaptor Proteins, Signal Transducing; Agar; Animals; Calmodulin-Binding Proteins; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeleton; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Ligands; Microscopy, Fluorescence; Models, Biological; Mutation; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; src Homology Domains; Tyrosine | 2003 |
Tyrosine 116 of the herpes simplex virus type 1 IEalpha22 protein is an ocular virulence determinant and potential phosphorylation site.
Topics: Animals; Chlorocebus aethiops; Cornea; Epitopes; Female; Herpesvirus 1, Human; Immediate-Early Proteins; Keratitis, Herpetic; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Mutation; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Isoforms; Tyrosine; Vero Cells; Viral Regulatory and Accessory Proteins; Virulence | 2003 |
Tyrosine phosphorylation in human lymphomas.
Topics: Cell Nucleus; Cytoplasm; Humans; Lymphoma, Non-Hodgkin; Lymphomatoid Papulosis; Microfilament Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 2002 |
A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.
Topics: Agar; Amino Acid Sequence; Animals; Binding Sites; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Conserved Sequence; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; ETS Translocation Variant 6 Protein; Fibroblasts; Genes, Dominant; Genetic Vectors; Humans; Insulin Receptor Substrate Proteins; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; NIH 3T3 Cells; Oncogene Proteins, Fusion; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ets; Receptor, trkC; Repressor Proteins; Retroviridae; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Tyrosine | 2004 |
Angiotensin II mediates Tyr-dephosphorylation in rat fetal kidney membranes.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Imidazoles; Immunoblotting; Kidney; Oligopeptides; Phosphorylation; Phosphotyrosine; Pyridines; Rats; Rats, Inbred WKY; Signal Transduction; Tyrosine; Vanadates | 2003 |
A novel competitive ELISA for both free and protein-bound nitrotyrosine.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutaral; Humans; Mice; Peroxynitrous Acid; Phenylalanine; Phosphotyrosine; Protein Binding; Reactive Nitrogen Species; Tyrosine | 2003 |
Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Humans; Imatinib Mesylate; Mice; Phosphorylation; Phosphotyrosine; Piperazines; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Pyrimidines; src Homology Domains; Two-Hybrid System Techniques; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Tyrosine phosphorylation of BIT on photic stimulation in the rat retina.
Topics: Animals; Antigens, Differentiation; Concanavalin A; Darkness; Immunohistochemistry; Light; Membrane Glycoproteins; Neural Cell Adhesion Molecule L1; Phosphorylation; Phosphotyrosine; Photic Stimulation; Rats; Receptors, Immunologic; Retina; src Homology Domains; Tyrosine | 2004 |
Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antibodies; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; ErbB Receptors; Humans; Hydrogen Peroxide; Milk Proteins; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Regulation and localization of CAS substrate domain tyrosine phosphorylation.
Topics: Animals; Antibodies; Cellular Apoptosis Susceptibility Protein; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Mice; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rabbits; Recombinant Proteins; Signal Transduction; src-Family Kinases; Substrate Specificity; Tyrosine; Vinculin | 2004 |
FK506 attenuates the post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Gerbillinae; Hippocampus; Immunosuppressive Agents; Male; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Tacrolimus; Tissue Distribution; Tyrosine | 2003 |
The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation.
Topics: Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Conserved Sequence; Dimerization; DNA Primers; DNA-Binding Proteins; Green Fluorescent Proteins; HeLa Cells; Humans; Kinetics; Luminescent Proteins; Mice; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; Tyrosine | 2004 |
The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.
Topics: Actins; Active Transport, Cell Nucleus; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cells, Cultured; Chemotaxis; Cytoskeleton; Dose-Response Relationship, Drug; Humans; Kinetics; Low Density Lipoprotein Receptor-Related Protein-1; Microscopy, Fluorescence; Mutation; Phosphotyrosine; Plasminogen Activator Inhibitor 1; Precipitin Tests; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Surface Plasmon Resonance; Time Factors; Tyrosine; Wound Healing | 2004 |
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Aorta; Cell Movement; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Glutathione Transferase; Humans; Immunoblotting; Microscopy, Fluorescence; Mutation; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; RNA, Small Interfering; Swine; Telomerase; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cortactin; Cricetinae; Enzyme Activation; Microfilament Proteins; Osmotic Pressure; Peptides; Phosphorylation; Phosphotyrosine; Polymers; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Thiazoles; Thiazolidines; Transfection; Tyrosine | 2004 |
Tensin stabilizes integrin adhesive contacts in Drosophila.
Topics: Animals; Animals, Genetically Modified; Cell Adhesion; Cytoskeleton; Drosophila; Embryo, Nonmammalian; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Gene Expression Regulation, Developmental; Genes, Insect; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization; Insect Proteins; Integrins; Larva; Luminescent Proteins; Microfilament Proteins; Models, Biological; Mutation; Phosphotyrosine; Polypyrimidine Tract-Binding Protein; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; src Homology Domains; Stress, Physiological; Talin; Tensins; Tyrosine; Wings, Animal | 2004 |
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Topics: Animals; Fatty Acids; Genotype; Glucose; HLA Antigens; Humans; Insulin; Insulin Resistance; Isoenzymes; Male; Mice; Mice, Transgenic; Muscles; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Signal Transduction; Transgenes; Tyrosine | 2004 |
Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.
Topics: Adaptor Proteins, Signal Transducing; Amyloid beta-Protein Precursor; Animals; Binding Sites; Enzyme Activation; GRB2 Adaptor Protein; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proteins; src Homology Domains; Tyrosine | 2004 |
Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state.
Topics: Adenosine Triphosphate; Animals; Baculoviridae; Catalysis; Enzyme Activation; Genetic Vectors; Janus Kinase 2; Models, Chemical; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; Spodoptera; Tyrosine | 2004 |
SH3P2 in complex with Cbl and Src.
Topics: Actins; Amino Acid Motifs; Animals; Cell Adhesion; Cell Line; DNA, Complementary; Fibroblasts; Fluorescent Antibody Technique, Indirect; Focal Adhesions; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Models, Biological; NIH 3T3 Cells; Oncogene Protein v-cbl; Osteoclasts; Peptides; Phosphorylation; Phosphotyrosine; Plasmids; Precipitin Tests; Protein Binding; Retroviridae Proteins, Oncogenic; Spleen; src-Family Kinases; Transfection; Two-Hybrid System Techniques; Tyrosine | 2004 |
Tyrosine phosphorylation, thiol status, and protein tyrosine phosphatase in rat epididymal spermatozoa.
Topics: Animals; Epididymis; Fluorescent Antibody Technique; Male; Oxidation-Reduction; Phosphorylation; Phosphotyrosine; Protamines; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Sperm Head; Sperm Tail; Sulfhydryl Compounds; Tyrosine | 2004 |
Proteomic method for identification of tyrosine-nitrated proteins.
Topics: Animals; Cells, Cultured; Databases, Protein; Electrophoresis, Gel, Two-Dimensional; Humans; Phosphorylation; Phosphotyrosine; Proteins; Proteomics; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2004 |
Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Chromatography; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Humans; Immunoblotting; Ligands; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 2004 |
Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity.
Topics: Actins; cdc42 GTP-Binding Protein; Chlamydia; Chlamydia Infections; Cholesterol; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; GTP Phosphohydrolases; HeLa Cells; Humans; Kinetics; Membrane Microdomains; Microscopy, Fluorescence; Models, Biological; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Plasmids; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Time Factors; Transfection; Tyrosine | 2004 |
Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.
Topics: Animals; Ankyrins; Cadherins; Cell Line; Cells, Cultured; Connexin 43; Cricetinae; Cytoskeleton; DNA, Complementary; Immunohistochemistry; Mice; Mice, Inbred C57BL; Muscle Proteins; Myocardium; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Sodium Channels; Transfection; Tyrosine | 2004 |
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).
Topics: Animals; Cell Cycle; Cell Line; DNA-Binding Proteins; Enzyme Activation; fms-Like Tyrosine Kinase 3; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Mice; Milk Proteins; Models, Molecular; Mutation; Phosphotyrosine; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2005 |
The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1.
Topics: Adenine; Gene Expression Regulation, Fungal; Immunophilins; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Transport; Protein Tyrosine Phosphatases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2004 |
Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.
Topics: Animals; Animals, Newborn; Cell Line; DNA, Complementary; Down-Regulation; Embryo, Mammalian; Gene Expression Regulation, Developmental; Genes, Lethal; Genotype; Heterozygote; Mice; Mice, Transgenic; Mutation; Neurons; Phosphotyrosine; Rats; Receptor, ErbB-2; Signal Transduction; Survival Rate; Tyrosine | 2004 |
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Topics: Apoptosis; B-Lymphocytes; Benzamides; Cell Cycle; Cell Line; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Enzymologic; Humans; Imatinib Mesylate; Mutation; Myeloproliferative Disorders; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine | 2004 |
Immunohistochemical analysis of tyrosine phosphorylation and AP-1 transcription factors c-Jun, Jun D, and Fos family during early ovarian follicle development in the mouse.
Topics: Animals; Antibodies, Phospho-Specific; Female; Immunohistochemistry; Mice; Ovarian Follicle; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription Factor AP-1; Tyrosine | 2004 |
Theoretical investigations of prostatic acid phosphatase.
Topics: Acid Phosphatase; Animals; Aspartic Acid; Binding Sites; Computer Simulation; Dimerization; ErbB Receptors; Histidine; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Models, Chemical; Models, Molecular; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Proteins; Proteomics; Rats; Receptor, ErbB-2; Static Electricity; Thermodynamics; Tyrosine | 2005 |
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Topics: Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Mass Spectrometry; Mice; Neoplasms; NIH 3T3 Cells; Peptides; Phosphorylation; Phosphotyrosine; Proteomics; Signal Transduction; Tyrosine | 2005 |
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis.
Topics: Animals; Cell Proliferation; Endocytosis; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Humans; MAP Kinase Signaling System; Mice; Mutation; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Signal Transduction; Type C Phospholipases; Tyrosine | 2005 |
The sulfogalactose moiety of sulfoglycosphingolipids serves as a mimic of tyrosine phosphate in many recognition processes. Prediction and demonstration of Src homology 2 domain/sulfogalactose binding.
Topics: Amino Acid Motifs; Binding Sites; Carbohydrate Conformation; Cell Adhesion; Cerebroside-Sulfatase; Chromatography, Thin Layer; Cloning, Molecular; Crystallography, X-Ray; DNA, Complementary; Galactose; Glycosphingolipids; HSP70 Heat-Shock Proteins; Humans; Hydrogen Bonding; Leukocytes, Mononuclear; Ligands; Models, Chemical; Models, Molecular; Phosphates; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; src Homology Domains; Sulfates; Tyrosine | 2005 |
Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.
Topics: Antineoplastic Agents; Chromatography, Affinity; Chromatography, Liquid; Humans; Immunoprecipitation; Interferon-alpha; Janus Kinase 1; Jurkat Cells; Metals; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteomics; Receptors, Interferon; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; TYK2 Kinase; Tyrosine | 2005 |
Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6.
Topics: Endometrium; Female; Humans; Interleukin-6; Janus Kinase 1; Male; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-6; Signal Transduction; Sperm Capacitation; Spermatozoa; Tyrosine | 2005 |
beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Line, Tumor; Databases, Protein; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Heat-Shock Proteins; Heterogeneous-Nuclear Ribonucleoprotein K; HSP27 Heat-Shock Proteins; Humans; Image Processing, Computer-Assisted; Inhibitory Concentration 50; Isoelectric Focusing; Isothiocyanates; Macrophage Migration-Inhibitory Factors; Mass Spectrometry; Molecular Chaperones; Neoplasm Proteins; Phosphotyrosine; Plant Proteins; Proteomics; Proto-Oncogene Proteins c-myc; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin; Tyrosine; Up-Regulation | 2005 |
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.
Topics: Animals; Carcinoma; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Collagen; Colon; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Liver; Liver Neoplasms; Male; Microcirculation; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Oligonucleotides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Tyrosine | 2005 |
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
Topics: Animals; Blotting, Western; Cell Adhesion; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Humans; Immunoblotting; Immunoprecipitation; Mutation; Neoplasms; Paxillin; Peptides; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 3; src-Family Kinases; Thyroid Gland; Thyroid Neoplasms; Transfection; Tyrosine | 2005 |
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adipose Tissue; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Calcium; Calorimetry; CHO Cells; Cricetinae; Crystallography, X-Ray; Electrons; Immunoblotting; Immunoprecipitation; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; Thermodynamics; Transfection; Tyrosine | 2005 |
Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells.
Topics: Blotting, Western; Cell Line; CSK Tyrosine-Protein Kinase; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Green Fluorescent Proteins; NADPH Oxidases; Oxygen; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pulmonary Artery; Pyrimidines; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA, Small Interfering; src-Family Kinases; Superoxides; Transfection; Tyrosine | 2005 |
In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatography, High Pressure Liquid; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Kinetics; Light; Models, Chemical; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Recombinant Fusion Proteins; Signal Transduction; Time Factors; Tyrosine | 2005 |
Regulation of translation by ribosome shunting through phosphotyrosine-dependent coupling of adenovirus protein 100k to viral mRNAs.
Topics: Adenoviridae; Cell Line; Eukaryotic Initiation Factor-4G; Humans; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Ribosomes; RNA, Messenger; RNA, Viral; Tyrosine; Viral Proteins | 2005 |
The role of protein-tyrosine phosphatase 1B in integrin signaling.
Topics: Amino Acid Motifs; Binding Sites; Cell Line; Cell Movement; Crk-Associated Substrate Protein; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoblotting; Immunoprecipitation; Integrins; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Models, Chemical; Mutation; Phosphorylation; Phosphotyrosine; Proline; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; src-Family Kinases; Transfection; Tyrosine | 2005 |
Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.
Topics: Animals; Blotting, Western; Cell Proliferation; Enzyme Inhibitors; Epithelium; Lens, Crystalline; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Swine; Tyrosine; Tyrphostins | 2005 |
Capacitation-associated protein tyrosine phosphorylation and membrane fluidity changes are impaired in the spermatozoa of asthenozoospermic patients.
Topics: Adult; Analysis of Variance; Blotting, Western; Bucladesine; Case-Control Studies; Cells, Cultured; Fluorescent Antibody Technique, Indirect; Humans; Image Processing, Computer-Assisted; Male; Membrane Fluidity; Microscopy, Fluorescence; Oligospermia; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphorylation; Phosphotyrosine; Sperm Capacitation; Sperm Motility; Spermatozoa; Tyrosine | 2005 |
Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Budesonide; Dexamethasone; Female; Humans; Inflammation Mediators; Male; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Reference Values; Respiratory Mucosa; Tyrosine | 2005 |
Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation.
Topics: Animals; Biological Transport; Cell Adhesion; Cell Line; Cell Movement; Cells, Cultured; Cytoskeleton; Dogs; Electrophoresis, Polyacrylamide Gel; Genes, Dominant; Glycolysis; Immunoblotting; Mass Spectrometry; Microscopy, Fluorescence; Moloney murine sarcoma virus; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Protein Transport; Proteome; Pseudopodia; rho GTP-Binding Proteins; RNA; Tyrosine | 2005 |
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1.
Topics: Adaptor Proteins, Signal Transducing; Calcium; Cell Line; Epidermal Growth Factor; Gene Expression; GRB2 Adaptor Protein; Humans; Inositol 1,4,5-Trisphosphate; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; ras Proteins; RNA, Small Interfering; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 2005 |
Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; CD2 Antigens; DNA-Binding Proteins; Down-Regulation; Humans; Jurkat Cells; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; RNA-Binding Proteins; Tyrosine | 2005 |
Hypoxia-induced post-translational changes in red blood cell protein map of newborns.
Topics: Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Hypoxia; Image Processing, Computer-Assisted; Immunoblotting; In Vitro Techniques; Infant, Newborn; Methemoglobin; Oxidative Stress; Oxygen; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Silver Staining; Time Factors; Tyrosine; Umbilical Veins | 2005 |
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Carbazoles; Enzyme Inhibitors; Gene Silencing; Humans; Indole Alkaloids; Kinetics; Mutation; Neoplasm Metastasis; Phenotype; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Transduction, Genetic; Tumor Cells, Cultured; Tyrosine | 2005 |
Use of detergents to increase selectivity of immunoprecipitation of tyrosine phosphorylated peptides prior to identification by MALDI quadrupole-TOF MS.
Topics: Glucosides; Humans; Immunoprecipitation; Micelles; Neurons; Peptide Fragments; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Receptor, EphB2; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
The elucidation of novel SH2 binding sites on PLD2.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Division; Chlorocebus aethiops; COS Cells; Gene Expression Regulation; Humans; Immunoprecipitation; Molecular Sequence Data; Mutagenesis, Site-Directed; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Son of Sevenless Protein, Drosophila; src Homology Domains; Structure-Activity Relationship; Tyrosine | 2006 |
Functional hierarchy of the N-terminal tyrosines of SLP-76.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium; Cell Line, Tumor; Enzyme Activation; Humans; Mice; Mitogen-Activated Protein Kinases; Mutation; NFATC Transcription Factors; Phospholipase C gamma; Phosphoproteins; Phosphotyrosine; ras GTPase-Activating Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Tyrosine | 2006 |
Quantitative analysis of phosphotyrosine signaling networks triggered by CD3 and CD28 costimulation in Jurkat cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CD28 Antigens; CD3 Complex; Humans; Jurkat Cells; Lymphocyte Activation; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 2006 |
Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Disulfides; Enzyme Activation; Mice; Phosphorylation; Phosphotyrosine; STAT Transcription Factors; STAT1 Transcription Factor; STAT3 Transcription Factor; Transfection; Tyrosine | 2006 |
Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space.
Topics: Adult; Detergents; Female; Fibronectins; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Male; Middle Aged; Neutrophils; Paxillin; Phosphotyrosine; Proto-Oncogene Proteins; src-Family Kinases; Tyrosine; Wounds and Injuries | 2006 |
Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Nucleus; Cell Proliferation; Chlorocebus aethiops; COS Cells; CSK Tyrosine-Protein Kinase; Green Fluorescent Proteins; HeLa Cells; Humans; Molecular Sequence Data; Mutation; Nuclear Localization Signals; Nuclear Matrix; Nuclear Matrix-Associated Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; src-Family Kinases; Transfection; Tyrosine | 2006 |
Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.
Topics: Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Drug Resistance, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ligands; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Quinazolines; Sequence Deletion; Tyrosine; Ubiquitin | 2007 |
Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions.
Topics: Amino Acid Sequence; Animals; Chickens; Crystallography, X-Ray; Integrins; Microfilament Proteins; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Talin; Tensins; Tyrosine | 2007 |
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.
Topics: Animals; Cell Line; GTPase-Activating Proteins; Humans; Integrins; Mice; Microfilament Proteins; Mutation; Oncogene Proteins; Phosphotyrosine; Protein Binding; src Homology Domains; Tensins; Tumor Suppressor Proteins; Tyrosine | 2007 |
Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach.
Topics: Amino Acid Sequence; Cell Adhesion; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; Isotope Labeling; Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine; Vanadates | 2007 |
Analysis of chaperone proteins associated with human spermatozoa during capacitation.
Topics: Acrosome Reaction; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum Chaperone BiP; Female; Flow Cytometry; Humans; Male; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Chaperones; Phosphorylation; Phosphotyrosine; Protein Binding; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Tyrosine; Zona Pellucida | 2007 |
Role of IRS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins.
Topics: Amino Acid Motifs; Animals; Binding Sites; Blood Proteins; Carrier Proteins; Cell Membrane; Chlorocebus aethiops; COS Cells; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Microscopy, Confocal; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Tyrosine | 2007 |
hTRPC1-associated alpha-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
Topics: Actinin; Blood Platelets; Blotting, Western; Calcium Signaling; Enzyme Inhibitors; Humans; Immunoprecipitation; In Vitro Techniques; Membrane Proteins; Multiprotein Complexes; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Platelet Activation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein-Tyrosine Kinases; Quinolines; Stromal Interaction Molecule 1; Thrombin; Time Factors; TRPC Cation Channels; Tyrosine | 2007 |
Role of tyrosine phosphorylation in U46619-induced vasoconstriction of pulmonary vasculature and its modulation by genistein, daidzein, and equol.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blotting, Western; Caffeine; Calcimycin; Cattle; Dose-Response Relationship, Drug; Equol; Genistein; In Vitro Techniques; Isoflavones; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Phytoestrogens; Potassium Chloride; Protein-Tyrosine Kinases; Proteins; Pulmonary Artery; Pulmonary Veins; Tyrosine; Vasoconstriction | 2007 |
Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase.
Topics: Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Proteins; Binding Sites; Catalysis; Cell Line; Crystallography, X-Ray; Dual Specificity Phosphatase 6; Immunoprecipitation; Lipoproteins; Lyases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 7; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Folding; Salmonella typhimurium; Shigella flexneri; Tyrosine | 2007 |
Targets of tyrosine nitration in diabetic rat retina.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Diabetic Retinopathy; Electrophoresis, Polyacrylamide Gel; Glucose Transporter Type 4; Immunoprecipitation; Male; Molecular Sequence Data; Nitrogen; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 2; Tyrosine; Vesicular Transport Proteins | 2008 |
Initiation of human myoblast differentiation via dephosphorylation of Kir2.1 K+ channels at tyrosine 242.
Topics: Amino Acid Sequence; Biotinylation; Cell Culture Techniques; Cell Differentiation; Cell Division; Cell Membrane; DNA; Electrophysiology; Electroporation; Gene Expression Regulation; Humans; Myoblasts; Phosphotyrosine; Potassium Channels, Inwardly Rectifying; Transfection; Tyrosine; Up-Regulation | 2008 |
A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R.
Topics: Cluster Analysis; ErbB Receptors; Humans; Intracellular Space; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Interaction Mapping; Receptor, Fibroblast Growth Factor, Type 1; Receptor, IGF Type 1; Recombinant Proteins; src Homology Domains; Substrate Specificity; Tyrosine | 2008 |
Immunoaffinity enrichments followed by mass spectrometric detection for studying global protein tyrosine phosphorylation.
Topics: Amino Acid Sequence; Antibodies; Chromatography, Liquid; Fourier Analysis; Humans; K562 Cells; Mass Spectrometry; Molecular Sequence Data; Nanotechnology; Peptide Fragments; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine | 2008 |
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
Topics: Animals; Cells, Cultured; Genes, Reporter; Heart Ventricles; Male; Mutagenesis; Myocardium; Myocytes, Cardiac; Phosphorylation; Phosphotyrosine; Protein Kinase C-delta; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Troponin I; Tyrosine | 2008 |
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
Topics: Aneuploidy; Animals; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Fibrosarcoma; Humans; Matrix Metalloproteinase 1; Mice; Neoplasm Invasiveness; Phosphorylation; Phosphotyrosine; Rats; Tyrosine | 2008 |
Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency.
Topics: B-Lymphocytes; Biomarkers; Electrophoretic Mobility Shift Assay; Female; Humans; Interleukin-2; Killer Cells, Natural; Male; Phosphorylation; Phosphotyrosine; Severe Combined Immunodeficiency; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Tyrosine | 2009 |
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Survival; DNA Damage; DNA Repair; DNA-Binding Proteins; Histones; Humans; Intracellular Signaling Peptides and Proteins; Mice; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Substrate Specificity; Tumor Suppressor Proteins; Tyrosine | 2009 |
FAK mediates the inhibition of glioma cell migration by truncated 24 kDa FGF-2.
Topics: Cell Line, Tumor; Cell Movement; Fibroblast Growth Factor 2; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Glioma; Humans; Neovascularization, Pathologic; Phosphorylation; Phosphotyrosine; Serine; Tyrosine | 2009 |
DNA repair: New tales of an old tail.
Topics: Animals; Apoptosis; Cell Survival; Chromatin Assembly and Disassembly; DNA Damage; DNA Repair; DNA-Binding Proteins; Histones; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tyrosine | 2009 |
Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin.
Topics: Animals; Caveolin 2; Cell Nucleus; Cells, Cultured; Fibroblasts; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Insulin; Luciferases; Mutation; Phosphorylation; Phosphotyrosine; Protein Transport; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Transcriptional Activation; Tyrosine | 2009 |
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Topics: Algorithms; Amino Acid Motifs; Cell Line; Chromatography, Liquid; Epidermal Growth Factor; Epithelial Cells; Humans; Mammary Glands, Human; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Interaction Mapping; Proteome; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2009 |
Response prediction to a multitargeted kinase inhibitor in cancer cell lines and xenograft tumors using high-content tyrosine peptide arrays with a kinetic readout.
Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; ErbB Receptors; Gene Expression Profiling; Humans; Kinetics; Mice; Mice, Nude; Neoplasms; Phosphorylation; Phosphotyrosine; Protein Array Analysis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Transplantation, Heterologous; Tyrosine | 2009 |
Positive selection of tyrosine loss in metazoan evolution.
Topics: Adaptation, Physiological; Animals; Biological Evolution; Evolution, Molecular; Fungal Proteins; Glycosylation; Humans; Methylation; Mutation; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Selection, Genetic; Signal Transduction; Substrate Specificity; Tyrosine | 2009 |
Regulation of hyperactivation by PPP2 in hamster spermatozoa.
Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flagella; Isoenzymes; Male; Mesocricetus; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Processing, Post-Translational; Sperm Capacitation; Sperm Motility; Spermatozoa; Time Factors; Tyrosine | 2010 |
Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth.
Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Gene Regulatory Networks; Glioblastoma; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Mutation; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 2010 |
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Cell Adhesion; Cell Movement; Humans; Jurkat Cells; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; T-Lymphocytes; Two-Hybrid System Techniques; Tyrosine | 2010 |
Detection of tyrosine phosphorylated proteins by combination of immunoaffinity enrichment, two-dimensional difference gel electrophoresis and fluorescent Western blotting.
Topics: Blotting, Western; Cell Line; Electrophoresis, Gel, Two-Dimensional; Fluorescence; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tyrosine | 2010 |
A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation.
Topics: HEK293 Cells; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; src-Family Kinases; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
Phosphorylation of human Argonaute proteins affects small RNA binding.
Topics: Argonaute Proteins; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factors; HEK293 Cells; Humans; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Ribonuclease III; RNA-Binding Proteins; RNA, Small Interfering; RNA, Small Untranslated; Tyrosine | 2011 |
Tyrosine phosphorylation enrichment and subsequent analysis by MALDI-TOF/TOF MS/MS and LC-ESI-IT-MS/MS.
Topics: Antibodies, Phospho-Specific; Chemistry Techniques, Analytical; Chromatography, Liquid; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2010 |
Integration of proteomic analyses to monitor the activity status of phosphorylation signaling.
Topics: Binding Sites; Cell Line, Tumor; Cell Membrane; Databases, Protein; Humans; Mass Spectrometry; Metals; Oxides; Phosphorylation; Phosphotyrosine; Proteome; Proteomics; Signal Transduction; Trypsin; Tyrosine | 2011 |
A fluorescence lifetime-based assay for abelson kinase.
Topics: Amino Acid Sequence; Biological Assay; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Peptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-abl; Spectrometry, Fluorescence; Substrate Specificity; Tyrosine | 2011 |
Tyrosine phosphorylation of actin during microcyst formation and germination in Polysphondylium pallidum.
Topics: Actins; Dictyosteliida; Morphogenesis; Organometallic Compounds; Osmolar Concentration; Phenanthrolines; Phosphorylation; Phosphotyrosine; Potassium Chloride; Protein Tyrosine Phosphatases; Spores; Time Factors; Tyrosine | 2011 |
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Binding Sites; Blotting, Western; Cell Adhesion; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytoskeletal Proteins; Fibronectins; HEK293 Cells; Humans; Imatinib Mesylate; K562 Cells; Microfilament Proteins; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; src Homology Domains; Tandem Mass Spectrometry; Tyrosine | 2011 |
Diabetic Retinopathy Is Associated with Decreased Tyrosine Nitrosylation of Vitreous Interleukins IL-1α, IL-1β, and IL-7.
Topics: Aged; Blood Glucose; Blotting, Western; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycated Hemoglobin; Humans; Immunoprecipitation; Interleukin-1alpha; Interleukin-1beta; Interleukin-7; Male; Middle Aged; Nitric Oxide; Phosphorylation; Phosphotyrosine; Tyrosine; Vitreous Body | 2011 |
Structure analysis of the Staphylococcus aureus UDP-N-acetyl-mannosamine dehydrogenase Cap5O involved in capsular polysaccharide biosynthesis.
Topics: Amino Acid Sequence; Carbohydrate Dehydrogenases; Catalysis; Crystallography, X-Ray; Disulfides; Mass Spectrometry; Molecular Conformation; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Phagocytosis; Phosphorylation; Phosphotyrosine; Polysaccharides; Sequence Homology, Amino Acid; Staphylococcus aureus; Tyrosine | 2011 |
Impact of epididymal maturation, ejaculation and in vitro capacitation on tyrosine phosphorylation patterns exhibited of boar (Sus domesticus) spermatozoa.
Topics: Animals; Blotting, Western; Ejaculation; Epididymis; Male; Phosphorylation; Phosphotyrosine; Sperm Capacitation; Spermatozoa; Sus scrofa; Tyrosine | 2011 |
Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Differentiation; Cytoplasm; Focal Adhesion Protein-Tyrosine Kinases; Integrin beta1; Isotope Labeling; Keratinocytes; Mice; Mice, Transgenic; Molecular Sequence Data; Mutant Proteins; Peptides; Phosphorylation; Phosphotyrosine; Precancerous Conditions; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Structure-Activity Relationship; Tyrosine | 2011 |
Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis.
Topics: Antibody Affinity; Chromatography, Liquid; Enzyme Activation; HeLa Cells; Humans; Immunoassay; Mass Spectrometry; Multiprotein Complexes; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteolysis; Sensitivity and Specificity; Time Factors; Tyrosine | 2012 |
Simultaneous identification of tyrosine phosphorylation and sulfation sites utilizing tyrosine-specific bromination.
Topics: Catalytic Domain; Halogenation; Hydrobromic Acid; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphoric Monoester Hydrolases; Phosphotyrosine; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfatases; Tandem Mass Spectrometry; Tyrosine | 2011 |
Discrimination between peptide O-sulfo- and O-phosphotyrosine residues by negative ion mode electrospray tandem mass spectrometry.
Topics: Ions; Peptides; Phosphotyrosine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2011 |
Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail.
Topics: Amino Acid Sequence; Cell Line; Cytoplasm; Integrin beta3; Models, Molecular; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Platelet Membrane Glycoprotein IIb; Protein Conformation; Signal Transduction; Tyrosine | 2011 |
A strategy for identification of protein tyrosine phosphorylation.
Topics: Antibodies; Culture Media; Databases, Protein; Humans; Immunoassay; K562 Cells; Mass Spectrometry; Peptides; Phosphorylation; Phosphotyrosine; Proteome; Proteomics; Sensitivity and Specificity; Tyrosine | 2012 |
Development of unique antibodies directed against each of the six different phosphotyrosine residues within the T cell receptor CD3ζ chain.
Topics: Animals; Antibodies; CD3 Complex; Cell Line, Transformed; Epitopes; HEK293 Cells; Humans; Immune Sera; Mice; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Rabbits; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Signal Transduction; src Homology Domains; T-Lymphocytes; Tyrosine | 2012 |
Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Chlorpyrifos; Cholinesterase Inhibitors; Insecticides; Limit of Detection; Mice; Molecular Sequence Data; Phosphotyrosine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2012 |
PredSulSite: prediction of protein tyrosine sulfation sites with multiple features and analysis.
Topics: Algorithms; Amino Acid Sequence; Computational Biology; Databases, Protein; Internet; Models, Molecular; Molecular Sequence Data; Phosphotyrosine; Protein Structure, Secondary; Proteins; ROC Curve; Tyrosine | 2012 |
PKL01, an Ndr kinase homologue in plant, shows tyrosine kinase activity.
Topics: Lotus; Phosphorylation; Phosphotyrosine; Plant Proteins; Protein Serine-Threonine Kinases; Tyrosine | 2012 |
Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria.
Topics: Adaptor Proteins, Signal Transducing; Carcinoembryonic Antigen; Cytoplasm; Fluorescence Resonance Energy Transfer; Granulocytes; HEK293 Cells; HeLa Cells; Humans; Neisseria gonorrhoeae; Oligonucleotide Array Sequence Analysis; Phagocytosis; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Tyrosine | 2012 |
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzamides; Blast Crisis; Cell Membrane; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Phosphotyrosine; Piperazines; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tyrosine | 2013 |
Structural and biophysical characterization of the Syk activation switch.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Crystallography, X-Ray; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Models, Molecular; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Surface Plasmon Resonance; Syk Kinase; Thermodynamics; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2013 |
Hydrogen bond strengths in phosphorylated and sulfated amino acid residues.
Topics: Amino Acids; Arginine; Computational Biology; Databases, Protein; Glutamic Acid; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Peptides; Phosphates; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Proteins; Solvents; Static Electricity; Tyrosine | 2013 |
Analysis of tyrosine phosphorylation and phosphotyrosine-binding proteins in germinating seeds from Scots pine.
Topics: Carrier Proteins; Germination; Phosphorylation; Phosphotyrosine; Pinus sylvestris; Seeds; Tyrosine | 2013 |
Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain.
Topics: Amino Acid Sequence; Humans; Models, Molecular; Molecular Sequence Data; Phosphotyrosine; Protein Binding; Protein Conformation; Sequence Alignment; src Homology Domains; STAT1 Transcription Factor; Tyrosine | 2013 |
Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography.
Topics: Chromatography, Affinity; Chromatography, Liquid; HeLa Cells; Humans; Immunoprecipitation; K562 Cells; Metals; Peptides; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proteomics; Signal Transduction; Tyrosine | 2013 |
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Cisplatin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunosuppressive Agents; Jurkat Cells; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proteomics; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 2013 |
A novel assay method for calcium calmodulin dependent phosphatase from bovine brain extract.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Calcineurin; Calcium; Calmodulin; Cattle; Kinetics; Phosphotyrosine; Tissue Extracts; Tyrosine | 2014 |
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; ErbB Receptors; Fluorescence Polarization; Humans; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-met; Receptors, Androgen; Signal Transduction; src Homology Domains; Tyrosine | 2014 |
Purification of pre-miR-29 by a new O-phospho-l-tyrosine affinity chromatographic strategy optimized using design of experiments.
Topics: Chromatography, Affinity; Imaging, Three-Dimensional; MicroRNAs; Temperature; Tyrosine | 2014 |
Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics.
Topics: Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; ErbB Receptors; Extracellular Matrix; Humans; Kidney Neoplasms; Mass Spectrometry; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteomics; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2016 |
Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Estrogen Receptor beta; Female; HEK293 Cells; Humans; Ki-67 Antigen; Ligands; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Transplantation; p300-CBP Transcription Factors; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitination | 2016 |
Tyrosine Residues Regulate Multiple Nuclear Functions of P54nrb.
Topics: Animals; Cell Line, Tumor; Cell Nucleus; HEK293 Cells; Humans; Mice; Phosphotyrosine; Protein Binding; Receptors, Androgen; Repressor Proteins; RNA Splicing; RNA-Binding Proteins; Transcription, Genetic; Tyrosine | 2017 |
Eph-mediated tyrosine phosphorylation of citron kinase controls abscission.
Topics: Amino Acid Sequence; Animals; Cell Death; Cytokinesis; Ephrin-B2; Female; HEK293 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Signal Transduction; src-Family Kinases; Telophase; Tyrosine | 2016 |
NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.
Topics: Campylobacter jejuni; Cell Line; Dihydroxyphenylalanine; Drug Resistance, Bacterial; Heme; Host-Pathogen Interactions; Humans; Hydrogen Peroxide; Immune System; Klebsiella pneumoniae; Listeria monocytogenes; NADPH Oxidases; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen; Peroxidase; Phosphotyrosine; Reactive Oxygen Species; Salmonella enterica; Tyrosine | 2016 |
Neutral Loss Is a Very Common Occurrence in Phosphotyrosine-Containing Peptides Labeled with Isobaric Tags.
Topics: Peptides; Phosphotyrosine; Reagent Kits, Diagnostic; Spectrometry, Mass, Electrospray Ionization; Staining and Labeling; Tyrosine | 2017 |
SH2 Domain Histochemistry.
Topics: Immunohistochemistry; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; src Homology Domains; Tyrosine | 2017 |
Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chromatography, Liquid; Databases, Protein; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 13; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteomics; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2017 |
Sensitive Approaches for the Assay of the Global Protein Tyrosine Phosphorylation in Complex Samples Using a Mutated SH2 Domain.
Topics: Blotting, Western; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; src Homology Domains; Tyrosine | 2017 |
Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Afatinib; Biomarkers, Tumor; Cell Line, Tumor; Cluster Analysis; ErbB Receptors; Erlotinib Hydrochloride; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteomics; Quinazolines; Reproducibility of Results; Signal Transduction; Tyrosine | 2017 |
Site-specific incorporation of phosphotyrosine using an expanded genetic code.
Topics: Animals; Genetic Code; Phosphorylation; Phosphotyrosine; Proteins; Tyrosine | 2017 |
CCR7 Sulfotyrosine Enhances CCL21 Binding.
Topics: Amino Acid Sequence; Binding Sites; Chemokine CCL21; Humans; Ligands; Magnetic Resonance Spectroscopy; Peptides; Phosphotyrosine; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Receptors, CCR7; Tyrosine | 2017 |
SH2 Superbinder Modified Monolithic Capillary Column for the Sensitive Analysis of Protein Tyrosine Phosphorylation.
Topics: Equipment Design; HeLa Cells; Humans; Phosphorylation; Phosphotyrosine; Proteomics; Tyrosine | 2018 |
Distinguishing Sulfotyrosine Containing Peptides from their Phosphotyrosine Counterparts Using Mass Spectrometry.
Topics: Amino Acid Sequence; Humans; Peptides; Phosphotyrosine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2018 |
Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.
Topics: Genes, src; Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Tyrosine | 2018 |
Structural basis for the preference of the
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Models, Molecular; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Conformation; Substrate Specificity; Tungsten Compounds; Tyrosine | 2018 |
Facile preparation of multifunctionalisable 'stealth' upconverting nanoparticles for biomedical applications.
Topics: Alendronate; Amines; Biomedical Engineering; Fluorides; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ligands; Luminescence; Nanoparticles; Nanotechnology; Polyethylene Glycols; Serum; Surface Properties; Tyrosine; Water; Yttrium | 2018 |
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Communication; Drosophila; HEK293 Cells; HeLa Cells; Humans; Ligands; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Receptor Protein-Tyrosine Kinases; Receptor, EphA4; Signal Transduction; src Homology Domains; Tyrosine | 2018 |
DoE to improve supercoiled p53-pDNA purification by O-phospho-l-tyrosine chromatography.
Topics: Chromatography, Affinity; DNA, Recombinant; DNA, Superhelical; Escherichia coli; Plasmids; Reproducibility of Results; Research Design; Tumor Suppressor Protein p53; Tyrosine | 2019 |
Global targeting of functional tyrosines using sulfur-triazole exchange chemistry.
Topics: A549 Cells; Binding Sites; Fluorine; Glutathione S-Transferase pi; HEK293 Cells; Humans; Molecular Probes; Phosphorylation; Phosphotyrosine; Protein Domains; Protein Processing, Post-Translational; Proteomics; Sulfinic Acids; Sulfur; Triazoles; Tyrosine | 2020 |
The phosphatase-like activity of zirconium oxide nanoparticles and their application in near-infrared intracellular imaging.
Topics: Adenosine Triphosphate; Biomimetics; Catalysis; HeLa Cells; Humans; Infrared Rays; Molecular Structure; Nanoparticles; Optical Imaging; Particle Size; Phosphoric Monoester Hydrolases; Phosphorylation; Spectrometry, Fluorescence; Surface Properties; Tyrosine; Zirconium | 2020 |
EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Integrin beta4; Mass Spectrometry; Phosphorylation; Phosphotyrosine; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Tyrosine | 2021 |
Peptide probes containing a non-hydrolyzable phosphotyrosine-mimetic residue for enrichment of protein tyrosine phosphatases.
Topics: Amino Acid Sequence; Peptides; Phosphotyrosine; Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine | 2022 |
Discerning Tyrosine Phosphorylation from Multiple Phosphorylations Using a Nanofluidic Logic Platform.
Topics: Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Serine; Threonine; Tyrosine | 2021 |
A Tyrosine Phosphoproteome Analysis Approach Enabled by Selective Dephosphorylation with Protein Tyrosine Phosphatase.
Topics: Humans; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proteome; Proteomics; Reproducibility of Results; Tyrosine | 2022 |
SH2-Domain Protein Isolation Using Synthetic Phosphorylated Peptides to Study VEGFR2 Signaling.
Topics: Endothelial Cells; Phosphorylation; Phosphotyrosine; src Homology Domains; Tyrosine; Vascular Endothelial Growth Factor A | 2022 |
Genetic encoding of a nonhydrolyzable phosphotyrosine analog in mammalian cells.
Topics: Animals; Mammals; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Tyrosine | 2022 |
Highly selective titanium (IV)-immobilized O-phospho-L-tyrosine modified magnetic nanoparticles for the enrichment of intact phosphoproteins.
Topics: Caseins; Humans; Magnetite Nanoparticles; Nanoparticles; Phosphopeptides; Phosphoproteins; Titanium; Tyrosine | 2022 |
EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; N-Acetylglucosaminyltransferases; Neoplasms; Phosphorylation; Phosphotyrosine; Pyruvate Kinase; STAT5 Transcription Factor; Tyrosine | 2022 |
Integrated and High-Throughput Approach for Sensitive Analysis of Tyrosine Phosphoproteome.
Topics: ErbB Receptors; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteome; Reproducibility of Results; Tyrosine | 2022 |
Microtumor Spheroids Provide a Model for Studying Molecules Involved in Vascular Organization: An Illustrative Study for VE-cadherin.
Topics: Animals; Antigens, CD; Cadherins; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Neovascularization, Pathologic; Phosphorylation; Phosphotyrosine; Sunitinib; Tyrosine | 2022 |
Dynamic Phosphotyrosine-Dependent Signaling Profiling in Living Cells by Two-Dimensional Proximity Proteomics.
Topics: Biological Phenomena; ErbB Receptors; Peptides; Phosphorylation; Phosphotyrosine; Proteomics; src Homology Domains; Tyrosine | 2022 |
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP.
Topics: GTPase-Activating Proteins; p120 GTPase Activating Protein; Phosphotyrosine; src Homology Domains; Tyrosine | 2022 |
High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display.
Topics: Humans; Peptide Library; Phosphopeptides; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; src Homology Domains; Tyrosine | 2023 |
Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides.
Topics: HEK293 Cells; Humans; Phosphopeptides; Phosphotyrosine; Proteins; Tyrosine; Workflow | 2023 |