phosphotyrosine has been researched along with tetradecanoylphorbol acetate in 208 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (9.62) | 18.7374 |
| 1990's | 155 (74.52) | 18.2507 |
| 2000's | 27 (12.98) | 29.6817 |
| 2010's | 5 (2.40) | 24.3611 |
| 2020's | 1 (0.48) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey, TL; Burns, C; McVicar, DW; O'Shea, JJ; Smyth, MJ | 1 |
| Goldstein, BJ; Hashimoto, N | 1 |
| Min, HK; Park, DJ; Rhee, SG | 1 |
| Fletcher, MC; Freeman, GJ; June, CH; Kamoun, M; Ledbetter, JA; Nadler, LM; Thompson, CB; Turka, LA; Vandenberghe, P | 1 |
| Bierer, BE; Calvo, V; Crews, CM; Vik, TA | 1 |
| Enberg, B; Hansson, A; Lobie, PE; Möller, C; Norstedt, G | 1 |
| Grosmaire, L; Kanner, SB; Ledbetter, JA; Masewicz, S; Odum, N; Svejgaard, A | 1 |
| Bird, TA; Saklatvala, J | 1 |
| Dotto, GP; Filvaroff, E; Stern, DF | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Clark, EA; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| Berkow, RL; Dodson, RW | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Abraham, RT; Dick, CJ; Einspahr, KJ; Leibson, PJ | 1 |
| Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Jeffs, RA; Outlaw, HE; Rhee, SG | 1 |
| Farrar, WL; Linnekin, D | 1 |
| Hirai, M; Shimizu, N | 1 |
| Clark, EA; Deans, J; Draves, K; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| Huber, BT; Muñoz, E; Zubiaga, AM | 1 |
| Alitalo, K; Comoglio, PM; Di Renzo, MF; Koskinen, P; Lehtola, L; Lehväslaiho, H; Sistonen, L | 1 |
| Chin, K; Gazit, A; Gilon, C; Levitzki, A; Mills, GB; Roifman, CM | 1 |
| DeFranco, AL; Gold, MR; Weinstein, SL | 1 |
| Furuya, W; Grinstein, S | 1 |
| Conklyn, MJ; Connelly, PA; Farrell, CA; Merenda, JM; Showell, HJ | 1 |
| Budnik, LT; Mukhopadhyay, AK | 1 |
| Faller, DV; Mundschau, LJ; Quiñones, MA; Rake, JB | 1 |
| Hanekom, C; Hultin, L; Nel, AE | 1 |
| Farrar, WL; Linnekin, D; Willette-Brown, J | 1 |
| Mueller-Lantzsch, N; Roeckel, D | 1 |
| Ishihara, N; Kobayashi, B; Nagao, K | 1 |
| Casnellie, JE; Lamberts, RJ | 1 |
| Comoglio, PM; Meldolesi, J; Pandiella-Alonso, A; Sturani, E; Toschi, L; Vicentini, LM; Zippel, R | 1 |
| Chinkers, M; Garbers, DL | 1 |
| Harford, JB; Klausner, RD; Patel, MD; Samelson, LE; Weissman, AM | 1 |
| Brown, KD; Gould, KL; Gould, SJ; Hunter, T; Isacke, CM; Meisenhelder, J | 1 |
| Bass, G; Wedner, HJ | 1 |
| Dull, TJ; Kahn, CR; Stegmann, EW; Ullrich, A; White, MF | 1 |
| Cooper, JA; Kazlauskas, A | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Brugge, JS; Golden, A | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Casnellie, JE; Thom, RE | 1 |
| Farrar, WL; Ferris, DK; Martensen, T; Willette-Brown, J | 1 |
| Decker, SJ; Harris, P | 1 |
| Bonak, VA; Casnellie, JE; Gomez-Cambronero, J; Huang, CK; Sha'afi, RI; Shiraishi, T; Wang, E | 1 |
| Bissell, MJ; Chin, S; Laszlo, A; Radke, K | 1 |
| Gorden, P; Grunberger, G; Taylor, SI; Zick, Y | 1 |
| Decker, SJ | 1 |
| Seedorf, K; Sherman, M; Ullrich, A | 1 |
| Horton, AA; Kanno, T; Kobuchi, H; Nishiuchi, T; Takehara, Y; Utsumi, K; Utsumi, T; Yasuda, T; Yoshioka, T | 1 |
| Burkly, LC; Danahey, KM; Maguire, JE; van Seventer, GA | 1 |
| Oliver, JM; Pfeiffer, JR | 1 |
| Baccarini, M; Decker, T; Eilers, A; Hipskind, RA; Horn, F; Schindler, C | 1 |
| Heidaran, MA; Li, W; Mischak, H; Mushinski, JF; Pierce, JH; Wang, LM; Yu, JC | 1 |
| Errasfa, M; Stern, A | 1 |
| Berti, L; Häring, H; Kellerer, M; Kroder, G; Mosthaf, L; Mushack, J; Seedorf, K; Seffer, E; Tippmer, S | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Ohmichi, M; Saltiel, AR; Sawada, T | 1 |
| Breitbart, H; Lax, Y; Rubinstein, S | 1 |
| Pratt, MM; Salathe, M; Wanner, A | 1 |
| Gould, GW; Merrall, NW; Plevin, RJ | 1 |
| Hajjar, DP; Hsu, HY; Nicholson, AC | 1 |
| Anel, A; Kleinfeld, AM; Richieri, GV | 1 |
| Chin, JE; Liu, F; Roth, RA | 1 |
| Bierer, BE; Hutchcroft, JE | 1 |
| Kahn, CR; Kim, SJ | 1 |
| Liu, F; Roth, RA | 1 |
| Falet, H; Rendu, F | 1 |
| Dubois, PM; Herndon, V; Kiener, PA; Klussman, K; Mittler, RS; O'Connell, MP; Schieven, GL | 1 |
| Berridge, MJ; Bootman, MD; Jenkins, AL; Stone, SR | 1 |
| Gupta, S; Kumar, G; Nel, A; Wang, S; Weiss, A | 1 |
| Hall, A; Ridley, AJ | 1 |
| Gould, GW; Graham, A; Malarkey, K; Paterson, A; Plevin, R; Saville, MK | 1 |
| Berton, G; Fumagalli, L; Laudanna, C; Sorio, C | 1 |
| Hattori, S; Katagiri, K; Katagiri, T; Nakamura, S; Yamamoto, T; Yoshida, T | 1 |
| Pfefferkorn, LC; Yeaman, GR | 1 |
| Izumi, H; Kohno, K; Kung, HF; Kuwano, M; Ono, M; Ushiro, S | 1 |
| Abboud, HE; Choudhury, GG; Fouqueray, B; Kiyomoto, H | 1 |
| Herberman, RB; Lin, WC; Rabinowich, H; Whiteside, TL | 1 |
| Hefti, F; Isono, F; Knüsel, B; Widmer, HR | 1 |
| Bayna, EM; Cheresh, DA; Klemke, RL; Yebra, M | 1 |
| Anderson, MT; Gitler, C; Herzenberg, LA; Staal, FJ | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Besmer, P; Hsiau, CW; Serve, H; Vosseller, K; Yee, NS | 1 |
| Bissell, MJ; Desprez, PY; Roskelley, CD | 1 |
| Cherqui, G; Plas, C; Zachayus, JL | 1 |
| Abu-Lawi, KI; Sultzer, BM | 1 |
| Garcia-Welsh, A; Laskin, DL; Laskin, JD; Molloy, CJ | 1 |
| Andersson, T; Eierman, D; Hellberg, C; Sjölander, A | 1 |
| Hundle, B; Messing, RO; Roivainen, R | 1 |
| Fernandez, A; Kiefer, J; McConkey, DJ; Neamati, N; Wright, S | 1 |
| Felder, MP; Hanafusa, H; Scholz, G | 1 |
| Kim, G; Yurkow, EJ | 1 |
| Hunter, T; Tracy, S; van der Geer, P | 1 |
| Brondello, JM; McKenzie, FR; Pouysségur, J; Rivard, N | 1 |
| Molloy, CJ; Pietras, KM; Taylor, DS; Turner, CE | 1 |
| Hardwick, JS; Sefton, BM | 1 |
| Mahon, TM; O'Neill, LA | 1 |
| Nakamura, S; Nishizuka, Y; Ogita, K; Yamaguchi, K | 1 |
| Adachi, K; Asano, H; Hamaguchi, M; Ito, T; Koizumi, KT; Murate, T; Saga, S; Saito, H; Watanabe, T; Yoshida, S | 1 |
| Pollock, AS; Santiesteban, HL | 1 |
| Danielsen, AG; Hosomi, Y; Liu, F; Roth, RA; Shii, K | 1 |
| Berenstein, EH; Siraganian, RP; Swaim, WD; Swieter, M | 1 |
| Chen, M; Hay, N; Kim, S; Li, W; Rockow, S; Wagner, AJ; Weichselbaum, RR; Xu, J; Yi, SE | 1 |
| Jones, PM; Persaud, SJ; Wheeler-Jones, CP | 1 |
| Gould, GW; Graham, A; Malarkey, K; McLees, A; Plevin, R | 1 |
| Calautti, E; Dotto, GP; Ezzell, RM; Missero, C; Stein, PL | 1 |
| Bierer, BE; Franklin, DP; Harrison-Findik, D; Hutchcroft, JE; Tsai, B; Varticovski, L | 1 |
| Blumberg, PM; Chang, EY; Haleem-Smith, H; Rivera, J; Szallasi, Z | 1 |
| Kobuchi, H; Nojima, S; Saibara, T; Utsumi, K; Yasuda, T | 1 |
| Hartle, JE; Quarles, LD; Siddhanti, SR | 1 |
| Bos, JL; Hordijk, PL; Medema, RH; Moolenaar, WH; van Corven, EJ | 1 |
| Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
| Bombien, E; Offermanns, S; Schultz, G | 2 |
| Kobuchi, H; Kurashige, T; Minakami, K; Miyahara, M; Utsumi, K; Watanabe, Y | 1 |
| Bongrand, P; Bouhamdan, M; Capo, C; Huang, CK; Mege, JL; Sanguedolce, MV | 1 |
| Bell, SM; Connolly, DC; Degen, JL; Maihle, NJ | 1 |
| Nishimura, H; Simpson, IA; Zarnowski, MJ | 1 |
| Kellie, S; Murphy, CT; Westwick, J | 1 |
| Dombrádi, V; Ferber, E; Gergely, P; Goldman, R; Szücs, K; Zor, U | 1 |
| Broxmeyer, HE; Horie, M; Yip-Schneider, MT | 1 |
| Burns, DM; Kawase, T; Ogata, S; Orikasa, M | 1 |
| Bates, ME; Bertics, PJ; Busse, WW | 1 |
| Amino, N; Liu, G; Sumizaki, H; Takano, T | 1 |
| DiGiovanni, J; Imamoto, A; Kiguchi, K; Rupp, T; Xian, W; Zilberstein, A | 1 |
| Cohen, DA; Fitzpatrick, EA; Kaplan, AM | 1 |
| Edwards, SW; Galvani, DW; Lowe, GM; Slupsky, JR | 1 |
| Azuma, E; Furukawa, Y; Kitagawa, S; Masuyama, J; Takahashi, M; Takaku, F; Yagisawa, M; Yoshida, M; Yuo, A | 1 |
| Herrera, R; Petruzzelli, L; Takami, M | 2 |
| Becker, E; Cabrera, N; Díaz-Rodríguez, E; Martín-Zanca, D; Pandiella, A | 1 |
| Bandyopadhyay, G; Farese, RV; Galloway, L; Standaert, ML | 1 |
| Hoshino, S; Inoue, S; Kanda, Y; Katada, T; Kishimoto, H; Kontani, K; Kukimonto, I | 1 |
| Le Marchand-Brustel, Y; Ricort, JM; Tanti, JF; Van Obberghen, E | 1 |
| Hase, H; Hirayama, E; Kim, J | 1 |
| Navé, BT; Shepherd, PR; Siddle, K | 1 |
| Bengtsson, T; Grenegård, M; Olsson, A; Sjögren, F; Stendahl, O; Zalavary, S | 1 |
| Chew, CS; Nakamura, K; Parente, J; Zhou, CJ | 1 |
| Donini, M; Dusi, S; Rossi, F; Wientjes, F | 1 |
| al-Shami, A; Bourgoin, SG; Naccache, PH | 1 |
| Cybulsky, AV; McTavish, AJ | 1 |
| Avraham, H; Avraham, S; Fu, Y; Hiregowdara, D; London, R | 1 |
| Hakeda, Y; Kameda, T; Kumegawa, M; Mano, H; Raisz, LG; Shiokawa, M | 1 |
| Billings, RE; Collier, JM; Miller, DR | 1 |
| Beaven, MA; Hirasawa, N; Zhang, C | 1 |
| Rainsford, E; Reen, DJ | 1 |
| Butler, J; Downey, GP; Fialkow, L; Grinstein, S; Schelm, JA; Sue-A-Quan, AK; Vlahos, CJ | 1 |
| Kasai, T; Nozawa, Y; Ohguchi, K | 1 |
| Ansotegui, IJ; Galron, D; Isakov, N | 1 |
| Kapus, A; Ligeti, E; Mócsai, A; Suszták, K | 1 |
| Ito, Y; Nakashima, S; Nozawa, Y | 1 |
| Qin, S; Yamamura, H | 1 |
| Hershkoviz, R; Kachalsky, SG; Lider, O; Miron, S | 1 |
| Bertics, PJ; Cha, D; Houtman, JC; Wiepz, GJ | 1 |
| Olive, D; Parry, RV; Sansom, DM; Ward, SG; Westwick, J | 1 |
| Eckberg, WR | 1 |
| Jensen, RT; Kusui, T; Tsuda, T | 1 |
| Bouchie, JL; Feener, EP; Folli, F; Hansen, H; Kahn, CR | 1 |
| Briski, KP; Hosick, HL; McIntyre, BS; Sylvester, PW | 1 |
| Kuan, CY; Lee, SC; Wen, ZD; Yang, SD | 1 |
| Fujiwara, K; Kita, T; Kume, N; Masuda, M; Moriwaki, H; Nishi, E; Ochi, H | 1 |
| Clayton, PE; Love, DW; Silva, CM; Whatmore, AJ | 1 |
| Cobb, RR; Qiu, W; Scholz, W | 1 |
| Blank, U; Kawakami, T; Launay, P; Lehuen, A; Monteiro, RC | 1 |
| Chan, AS; Cook, ME; Dell, CL; Hunt, SW; Shimizu, Y; Warden, CS; Zell, T | 1 |
| Hawker, J; Huang, Q; Meng, FY; Wu, HM; Yuan, Y | 1 |
| Baricos, WH; Dipp, S; El-Dahr, SS | 1 |
| Mollerup, S; Rivedal, E; Sanner, T; Vikhamar, G | 1 |
| Jope, RS; Zhang, L | 1 |
| Gómez-Muñoz, A; Hundal, R; O'Brien, L; Steinbrecher, UP | 1 |
| Hirai, H; Kitagawa, S; Kitamura, T; Okuma, E; Saeki, K; Takaku, F; Yagisawa, M; Yazaki, Y; Yuo, A | 1 |
| Fisher, SK; Linseman, DA; Sorensen, SD | 1 |
| Chien, Y; Falkow, S; Healy, JI; Mecsas, J; Yao, T | 1 |
| Aggarwal, BB; Chintala, SK; Gokslan, Z; Kyritsis, AP; Mohan, PM; Mohanam, S; Rao, JS; Sawaya, R; Steck, P; Uhm, JH; Yung, WK | 1 |
| Cole, JA | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Junttila, I; Kovanen, PE; Li, W; Saharinen, P; Silvennoinen, O; Takaluoma, K; Valmu, L | 1 |
| Borrello, S; Colavitti, R; Galeotti, T; Pani, G | 1 |
| Bonvini, E; DeBell, KE; Graham, LJ; Mostowski, H; Rellahan, B; Stoica, B; Verí, M | 1 |
| Asazuma, N; Ohmori, T; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Aguilera, J; Chaïb-Oukadour, I; Gil, C; Pelliccioni, P | 1 |
| Cabrera, J; Díaz, R; Estévez, F; Fanjul, LF; Gallardo, G; López-Blanco, F; Quintana, J; Ruiz de Galarreta, CM; Santana, P; Tabraue, C | 1 |
| Heravi, J; McPhail, LC; Sergeant, S; Waite, KA | 1 |
| Wrenn, RW | 1 |
| Benovic, JL; Chalmers, C; Cook, SJ; Johnston, E; Palmer, TM; Pronin, A; Watterson, KR | 1 |
| Chan, SS; Junqueira, VB; Monteiro, HP; Schindler, F; Stern, A | 1 |
| Luo, Z; Ruderman, N; Song, Y; Wen, R; Xiang, X; Yuan, M | 1 |
| Bragado, MJ; García-Marin, LJ; Jensen, RT; Pace, A; Tapia, JA | 1 |
| Baba, A; Koyama, Y; Matsuda, T; Yoshioka, Y | 1 |
| García-Marin, LJ; Jensen, RT; Tapia, JA | 1 |
| Fujimoto, S; Imagawa, N; Kawakami-Honda, N; Nagasawa, K; Takemasa, H | 1 |
| Batty, IH; Downes, CP; Fleming, IN | 1 |
| Kim, CH; Kim, HM; Park, SY; Park, WH | 1 |
| Annis, DS; Barthel, SR; Duffy, AK; Johansson, MW; Lye, MH; Mosher, DF | 1 |
| Argetsinger, LS; Carter-Su, C; Cline, JM; Jensen, ON; Kouadio, JL; Mazurkiewicz-Munoz, AM; Stensballe, A | 1 |
| Babnigg, G; Lee, KM; Son, SW; Villereal, ML | 1 |
| Berna, MJ; Hoffmann, KM; Jensen, RT; Mantey, SA; Pace, A; Tapia, JA; Thill, M | 1 |
| Choi, YW; Hwang, MN; Jou, I; Kim, KS; Yoon, S | 1 |
| Hamada, J; Nomura, M; Nomura, N; Sugiyama, K | 1 |
| Barbato, G; De Francesco, R; Forte, E; Orsatti, L; Talamo, F; Tomei, L | 1 |
| Bertram, C; Hass, R; Schlegelberger, B; Skawran, B; Steinemann, D; von Neuhoff, N | 1 |
| Bertagnolo, V; Bonora, M; Brugnoli, F; Capitani, S; Grassilli, S; Nika, E; Pinton, P | 1 |
| Asara, J; Cantley, LC; Chiu, YH; Lee, JY | 1 |
| de Widt, J; Divecha, N; van Baal, J; van Blitterswijk, WJ | 1 |
| Chung, J; Joo, SY; Kang, D; Koo, MY; Lim, JM; Park, J; Rhee, SG; Shim, HB; Shin, SP; Woo, HA | 1 |
| Bertelsen, V; Dietrich, M; Malik, MS; Skeie, M; Stang, E | 1 |
| Cap, KC; Hamza, A; Kim, JG; Park, JB | 1 |
208 other study(ies) available for phosphotyrosine and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Cytosol; Flow Cytometry; Gene Expression Regulation; Humans; Hydrogen Peroxide; Immunoblotting; Kinetics; Lymphocyte Activation; Mice; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Interleukin-2; RNA; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1992 |
Differential regulation of mRNAs encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase C.
Topics: Animals; Culture Media, Serum-Free; Enzyme Activation; Half-Life; Insulin; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1992 |
Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Kinetics; Muromonab-CD3; Peptide Mapping; Phosphates; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases; Tyrosine | 1992 |
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD28 Antigens; Histocompatibility Antigens; Humans; In Vitro Techniques; Interleukin-2; Lactams, Macrocyclic; Leukocyte Common Antigens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Quinones; Receptor Aggregation; Receptors, Cell Surface; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Immunoblotting; Immunosuppressive Agents; Interleukin-2; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; DNA; Enzyme Activation; Glycogen Synthase Kinase 3; Growth Hormone; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Kinases; Rats; Receptors, Somatotropin; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transfection; Tyrosine | 1992 |
Superantigen and HLA-DR ligation induce phospholipase-C gamma 1 activation in class II+ T cells.
Topics: Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Enterotoxins; Enzyme Activation; HLA-D Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphotyrosine; Protein-Tyrosine Kinases; Staphylococcus aureus; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1992 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation.
Topics: Animals; Blotting, Western; Calcium; Cell Differentiation; Cytoskeleton; Cytosol; Genistein; Isoflavones; Keratinocytes; Mice; Mice, Inbred Strains; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Transglutaminases; Tyrosine | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; B-Lymphocytes; Calcium; Cell Division; Cross-Linking Reagents; Dose-Response Relationship, Immunologic; Histocompatibility Antigens; HLA-D Antigens; Humans; Immunoglobulin mu-Chains; Inositol Phosphates; Interleukin-4; Leukocyte Common Antigens; Lymphocyte Activation; Palatine Tonsil; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Tyrosine-specific protein phosphorylation during activation of human neutrophils.
Topics: Blotting, Western; Calcimycin; Cytosol; Humans; In Vitro Techniques; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.
Topics: Antigens, Differentiation; Cell Line; Clone Cells; Enzyme Activation; Humans; In Vitro Techniques; Interleukin-2; Interleukin-4; Killer Cells, Natural; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation.
Topics: Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoenzymes; Kinetics; Phosphates; Phosphoserine; Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.
Topics: Aluminum; Aluminum Compounds; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Calcium; CD40 Antigens; Cell Line; Cross-Linking Reagents; Fluorides; Genistein; Humans; Immunoglobulin M; Isoflavones; Lactams, Macrocyclic; Models, Biological; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine protein phosphorylation is required for protein kinase C-mediated proliferation in T cells.
Topics: Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Gene Expression; Humans; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression; Genes, ras; Humans; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1991 |
Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Humans; Immunoglobulin M; In Vitro Techniques; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Escherichia coli; Female; Kinetics; Lactams, Macrocyclic; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Salmonella; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3).
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Complement C5a; Cross-Linking Reagents; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemokine CCL2; Chemotactic Factors; Cyclic AMP; DNA; Gene Expression; Genes, ras; GTP-Binding Proteins; Mice; Phosphorylation; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; rap GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1991 |
Regulation of c-myc and ornithine decarboxylase expression by distinct protein kinase systems in IL-3-dependent myeloid cells.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Down-Regulation; Gene Expression; Genes, myc; Hematopoietic Stem Cells; In Vitro Techniques; Interleukin-3; Mice; Ornithine Decarboxylase; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Biochemical characterization of two Epstein-Barr virus early antigen-associated phosphopolypeptides.
Topics: Antibodies, Monoclonal; Antigens, Viral; Cell Line; Chromatin; DNA; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Molecular Weight; Phosphopeptides; Phosphoserine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine; Viral Proteins | 1985 |
Tyrosine phosphorylation of platelet protein induced by phorbol ester.
Topics: Animals; Blood Platelets; Enzyme Activation; Kinetics; Microscopy, Electron; Microscopy, Electron, Scanning; Molecular Weight; Phorbols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunologic Techniques; Immunosorbent Techniques; Lymphoma; Mice; Molecular Weight; Phorbols; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
PDGF-induced receptor phosphorylation and phosphoinositide hydrolysis are unaffected by protein kinase C activation in mouse Swiss 3T3 and human skin fibroblasts.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Humans; Mice; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Regulation of the phosphorylation state and function of the epidermal growth factor receptor by vitamin K-3.
Topics: Calcium; Cells, Cultured; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine; Vitamin K | 1986 |
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor.
Topics: Animals; Antigens; Isoelectric Point; Lymphocyte Activation; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.
Topics: Animals; Bombesin; Cells, Cultured; Gastrin-Releasing Peptide; Growth Substances; Kinetics; Mice; Mitogens; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
Characterization of an endogenous substrate of the insulin receptor in cultured cells.
Topics: Animals; Cell Line; Cloning, Molecular; Humans; Insulin; Liver Neoplasms, Experimental; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1987 |
Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.
Topics: Animals; Cell Line; Immunoassay; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.
Topics: Animals; Blood Platelets; Cell Line; Humans; Immunoblotting; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1989 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat.
Topics: Calcium; Cell Line; Diglycerides; Enzyme Activation; Humans; Immunoblotting; Molecular Weight; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
Interleukin 3 and phorbol ester stimulate tyrosine phosphorylation of overlapping substrate proteins.
Topics: Animals; Cell Line; Electrophoresis, Gel, Two-Dimensional; Interleukin-3; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Tyrosine phosphorylation in human neutrophil.
Topics: Cinnamates; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; In Vitro Techniques; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Sulfides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Genes; Molecular Weight; Peptide Biosynthesis; Phorbols; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1981 |
Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes.
Topics: Cells, Cultured; Humans; Monocytes; Phorbol Esters; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Inhibition of neutrophil superoxide generation by hypericin, an antiretroviral agent.
Topics: Anthracenes; Antiviral Agents; Azides; Cells, Cultured; Deferoxamine; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Humans; Light; Lipid Peroxides; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen; Perylene; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells.
Topics: Amino Acid Sequence; CD3 Complex; CD4-Positive T-Lymphocytes; CD58 Antigens; Cell Adhesion; Cell Adhesion Molecules; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Ligands; Molecular Sequence Data; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Fibronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vascular Cell Adhesion Molecule-1 | 1995 |
Tyrosine kinase-dependent assembly of actin plaques linking Fc epsilon R1 cross-linking to increased cell substrate adhesion in RBL-2H3 tumor mast cells.
Topics: Actins; Animals; Antigens; Cell Adhesion; Mast Cells; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.
Topics: alpha-Macroglobulins; Animals; Antibodies; Base Sequence; Binding Sites; Blotting, Western; Cell Differentiation; Cell Line; Cell Nucleus; DNA; Genes, fos; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-6; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Promoter Regions, Genetic; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Tryptophan-tRNA Ligase; Tyrosine | 1994 |
Tyrosine phosphorylation of protein kinase C-delta in response to its activation.
Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Genes, src; Interleukin-3; Isoenzymes; Mice; Molecular Sequence Data; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Topics: 3-O-Methylglucose; Animals; Cell Line; Fibroblasts; Glucose; Humans; Insulin; Isoenzymes; Kinetics; Mannitol; Methylglucosides; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
MAP kinase may play a role in the early phase of glucose transport in insulin treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Biological Transport, Active; Calcium-Calmodulin-Dependent Protein Kinases; Fibroblasts; Glucose; Glucose Transporter Type 1; Insulin; Mice; Monosaccharide Transport Proteins; Phorbol Esters; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Basic fibroblast growth factor-induced low density lipoprotein receptor transcription and surface expression. Signal transduction pathways mediated by the bFGF receptor tyrosine kinase.
Topics: Animals; Cells, Cultured; Cholesterol; Fibroblast Growth Factor 2; Gene Expression Regulation; Muscle, Smooth, Vascular; Phosphoproteins; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, LDL; RNA, Messenger; Signal Transduction; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1994 |
A tyrosine phosphorylation requirement for cytotoxic T lymphocyte degranulation.
Topics: Animals; Arsenicals; Calcium; Clone Cells; Concanavalin A; Fatty Acids, Nonesterified; Genistein; Ionomycin; Isoflavones; Kinetics; Lymphocyte Activation; Mice; Molecular Weight; Oleic Acid; Oleic Acids; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.
Topics: Animals; Blotting, Western; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.
Topics: Antigen-Antibody Complex; CD28 Antigens; Detergents; Humans; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Electrophoresis, Polyacrylamide Gel; Gene Expression; Insulin; Kinetics; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Insulin-stimulated tyrosine phosphorylation of protein kinase C alpha: evidence for direct interaction of the insulin receptor and protein kinase C in cells.
Topics: Animals; CHO Cells; Cricetinae; Insulin; Macromolecular Substances; Phosphotyrosine; Protein Binding; Protein Kinase C; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets.
Topics: Blood Platelets; Calcium; Edetic Acid; Enzyme Activation; Humans; Indoles; Maleimides; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tyrosine | 1994 |
CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.
Topics: Calcium; CD4 Antigens; CD4-Positive T-Lymphocytes; Egtazic Acid; Humans; In Vitro Techniques; Inositol Phosphates; Leukocyte Common Antigens; Phosphoproteins; Phosphotyrosine; Receptor Aggregation; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells.
Topics: Amino Acid Sequence; Calcium; Cyclic AMP; Humans; In Vitro Techniques; Molecular Sequence Data; Osteoblasts; Peptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Receptors, Thrombin; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Cells, Cultured; Tyrosine | 1994 |
The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.
Topics: Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Calcium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Genistein; GTP Phosphohydrolases; GTP-Binding Proteins; Isoflavones; Lysophospholipids; Mice; Models, Biological; Myosins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium; Cell Adhesion Molecules; Cell Line; Egtazic Acid; Endothelins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Homeostasis; Immunosorbent Techniques; Kinetics; Lysophospholipids; Molecular Sequence Data; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.
Topics: Amino Acid Sequence; Antibodies; CD18 Antigens; Cell Adhesion; Enzyme Activation; Epitopes; Humans; Integrins; Kinetics; Molecular Sequence Data; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
Topics: Benzoquinones; Cell Differentiation; Dexamethasone; Enzyme Activation; Granulocytes; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Monocytes; Mutation; Oncogene Protein p21(ras); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; ras GTPase-Activating Proteins; Rifabutin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1994 |
Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.
Topics: Cell Line; Humans; In Vitro Techniques; Interferon-gamma; Macromolecular Substances; Phosphotyrosine; Receptor Aggregation; Receptor Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Up-Regulation | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Phorbol 12-myristate 13-acetic acid inhibits PTP1B activity in human mesangial cells. A possible mechanism of enhanced tyrosine phosphorylation.
Topics: Glomerular Mesangium; Humans; Immunosorbent Techniques; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Topics: Benzoquinones; Cell Line; Gene Expression; Gene Rearrangement, T-Lymphocyte; Humans; In Vitro Techniques; Lactams, Macrocyclic; NF-kappa B; Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
Topics: Animals; DNA Mutational Analysis; Down-Regulation; Endopeptidases; Hematopoietic Cell Growth Factors; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Weight; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Stem Cell Factor; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Ubiquitins | 1994 |
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.
Topics: Animals; Caseins; Cell Aggregation; Cells, Cultured; Extracellular Matrix; Female; Gene Expression Regulation, Developmental; Genistein; In Vitro Techniques; Integrins; Isoflavones; Mice; Phosphotyrosine; Prolactin; Receptor Aggregation; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1994 |
Protein kinase C and insulin receptor beta-subunit serine phosphorylation in cultured foetal rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Enzyme Activation; Glucose; Glycogen; Insulin; Liver; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Swine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Alterations in expression of p56lck during myeloid differentiation of LSTRA cells.
Topics: Antigens, Differentiation; Bucladesine; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Cycle; Cell Differentiation; Cholecalciferol; Enzyme Induction; Granulocytes; Hematopoietic Stem Cells; Histocompatibility Antigens Class II; Humans; Leukemia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
The Ca2+ signaling capacity of the beta 2-integrin on HL60-granulocytic cells is abrogated following phosphorylation of its CD18-chain: relation to impaired protein tyrosine phosphorylation.
Topics: Calcium; CD18 Antigens; Cell Differentiation; Cell Line; Cytosol; Integrins; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Drug Synergism; Enzyme Activation; Ethanol; Fibroblast Growth Factor 2; Isoenzymes; Kinetics; Molecular Sequence Data; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.
Topics: Animals; Apoptosis; Calcium; CDC2 Protein Kinase; Cell Nucleus; DNA Damage; Lamin Type B; Lamins; Methylprednisolone; Mice; Mice, Inbred BALB C; Nuclear Proteins; Nucleosomes; Phosphotyrosine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors; Tyrosine | 1995 |
Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathways.
Topics: Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Chick Embryo; Chickens; Enzyme Activation; Fibroblasts; Gene Expression; Genes, ras; Genes, src; Oncogene Protein pp60(v-src); Oncogene Proteins v-raf; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins, Oncogenic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Effects of chromium on basal and insulin-induced tyrosine phosphorylation in H4 hepatoma cells: comparison with phorbol-12-myristate-13-acetate and sodium orthovanadate.
Topics: Animals; Chromium; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane.
Topics: 3T3 Cells; Animals; Base Sequence; Cytoplasm; DNA Primers; Fluorescent Antibody Technique; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Gene Expression; Genes, fos; GTP-Binding Proteins; Insulin; Intracellular Signaling Peptides and Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Receptors, Thrombin; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Becaplermin; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1995 |
Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Line; DNA Primers; Enzyme Activation; Humans; Hydrogen Peroxide; Leukemia, T-Cell; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A.
Topics: Animals; Benzoquinones; Cell Line; Dithiothreitol; Interleukin-1; Lactams, Macrocyclic; Mercaptoethanol; Mice; NF-kappa B; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Cricetinae; Cytosol; Durapatite; Enzyme Activation; Immunoblotting; Isoenzymes; Kinetics; Molecular Sequence Data; Phorbol 12,13-Dibutyrate; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Herbimycin A inhibits phorbol ester-induced morphologic changes, adhesion, and megakaryocytic differentiation of the leukemia cell line, MEG-01.
Topics: Benzoquinones; Cell Adhesion; Cell Differentiation; Genes, fos; Genes, jun; Humans; Lactams, Macrocyclic; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Naphthalenes; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Calbindin expression in renal tubular epithelial cells. Altered sodium phosphate co-transport in association with cytoskeletal rearrangement.
Topics: Actins; Animals; Base Sequence; Biological Transport; Calbindins; Calcium; Cell Line; Colforsin; Cytoskeleton; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Opossums; Phosphates; Phosphotyrosine; Proteins; Rats; Recombinant Proteins; S100 Calcium Binding Protein G; Sodium; Tetradecanoylphorbol Acetate; Tubulin; Tyrosine | 1995 |
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Division; CHO Cells; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Calcimycin; Calcium; Cell Line; Cloning, Molecular; Cytosol; DNA Primers; Gene Expression; Immunoblotting; Intracellular Signaling Peptides and Proteins; Leukemia, Basophilic, Acute; Mice; Molecular Sequence Data; Organ Specificity; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Receptors, IgE; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1.
Topics: Animals; Base Sequence; Cell Division; DNA; Enzyme Activation; Interferon-gamma; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred BALB C; Mitogens; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
The mitogen-activated protein kinase cascade in rat islets of Langerhans.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ethers, Cyclic; Glucose; Islets of Langerhans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase by protein kinase C and protein kinase A in EAhy926 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Indoles; Isoenzymes; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
fyn tyrosine kinase is involved in keratinocyte differentiation control.
Topics: Animals; Calcium; Cell Differentiation; Cortactin; Cytoskeleton; Enzyme Induction; Keratinocytes; Mice; Mice, Inbred SENCAR; Mice, Mutant Strains; Microfilament Proteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Skin; src-Family Kinases; Tetradecanoylphorbol Acetate; Time Factors; Transglutaminases | 1995 |
Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
Topics: Androstadienes; CD28 Antigens; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-2; Leukemia, T-Cell; Lymphocyte Activation; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Protein Binding; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition.
Topics: Animals; Antigens; Cell Line; Cell Membrane; Immunoglobulin E; Isoenzymes; Kinetics; Leukemia, Basophilic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Receptors, IgE; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Selective inhibition of human TNF-alpha action by flecainide acetate, an antiarrhythmic drug.
Topics: Animals; Anti-Arrhythmia Agents; Cell Survival; Dose-Response Relationship, Drug; Flecainide; Humans; In Vitro Techniques; L Cells; Membrane Potentials; Mice; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphotyrosine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; DNA; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Osteoblasts; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Effect of indomethacin and aspirin on the TNF-alpha-induced priming and protein tyrosyl phosphorylation of human neutrophils.
Topics: Animals; Aspirin; Azides; Electrophoresis, Polyacrylamide Gel; Granulocyte Colony-Stimulating Factor; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sodium Azide; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C.
Topics: Catechols; Genistein; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Monocytes; Naphthalenes; Nitriles; Phosphoproteins; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine; Tyrphostins; Vanadium; Zymosan | 1993 |
Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.
Topics: Animals; Cell Transformation, Viral; Chick Embryo; DNA Mutational Analysis; Gene Expression Regulation, Enzymologic; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tyrosine; Urokinase-Type Plasminogen Activator | 1993 |
Glucose transporter recycling in rat adipose cells. Effects of potassium depletion.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Blotting, Western; Cell Membrane; In Vitro Techniques; Insulin; Intracellular Membranes; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Potassium; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 2; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses.
Topics: Animals; Blood Platelets; Cells, Cultured; Genistein; Inositol 1,4,5-Trisphosphate; Ionomycin; Isoflavones; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1993 |
Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate.
Topics: Animals; Drug Synergism; Enzyme Activation; Female; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1993 |
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Division; Gene Expression; Genes, myc; Humans; Immunoblotting; Interleukin-7; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1993 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
IL-5 activates a 45-kilodalton mitogen-activated protein (MAP) kinase and Jak-2 tyrosine kinase in human eosinophils.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Eosinophils; Humans; Interleukin-5; Isoenzymes; Janus Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
Thyroid stimulating hormone and N6-2'-O-dibutyryladenosine 3'-5'-cyclic monophosphate decrease 110,000-130,000 M(r) tyrosine-phosphorylated substrate in rat thyroid cells.
Topics: Animals; Antibodies, Monoclonal; Bucladesine; Cell Culture Techniques; Cell Line; Immunoblotting; Insulin-Like Growth Factor I; Molecular Weight; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Vanadates | 1995 |
Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.
Topics: Administration, Topical; Animals; Blotting, Western; Carcinogens; Catechols; Enzyme Inhibitors; Epidermal Cells; ErbB Receptors; Female; Hyperplasia; Isoenzymes; Keratinocytes; Mice; Mice, Inbred SENCAR; Nitriles; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Pyridines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins | 1995 |
Defective CD4+ T cell signaling in murine AIDS: uncoupling of the T cell receptor complex from PIP2 hydrolysis.
Topics: Animals; Calcium; CD28 Antigens; CD4-Positive T-Lymphocytes; Female; Inositol 1,4,5-Trisphosphate; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1996 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
Activation of human monocyte functions by tumor necrosis factor: rapid priming for enhanced release of superoxide and erythrophagocytosis, but no direct triggering of superoxide release.
Topics: Adult; Complement C3b; Concanavalin A; Cytoplasm; Erythrocytes; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydrogen-Ion Concentration; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phagocytosis; Phosphotyrosine; Receptors, Leukocyte-Adhesion; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII.
Topics: Antibodies; B-Lymphocytes; Cell Adhesion; Cell Aggregation; Cell Line; Crk-Associated Substrate Protein; Cross-Linking Reagents; Glutathione Transferase; Humans; Intercellular Adhesion Molecule-1; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Recombinant Fusion Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment.
Topics: Animals; Blotting, Western; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Humans; Kinetics; Lysosomes; Mutagenesis, Site-Directed; Nerve Growth Factors; Phosphorylation; Phosphotyrosine; Point Mutation; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Effects of phorbol esters on insulin-induced activation of phosphatidylinositol 3-kinase, glucose transport, and glycogen synthase in rat adipocytes.
Topics: Adipocytes; Animals; Biological Transport; Cell Membrane; Enzyme Activation; Glucose; Glycogen Synthase; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Tetradecanoylphorbol Acetate | 1996 |
Induction of CD38/NADase and its monoclonal antibody-induced tyrosine phosphorylation in human leukemia cell lines.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Bucladesine; Cell Differentiation; Cell Line; HL-60 Cells; Humans; Kinetics; Leukemia; Membrane Glycoproteins; N-Glycosyl Hydrolases; NAD+ Nucleosidase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1996 |
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Further investigation of some inhibitors on myogenic differentiation: mechanism of inhibition with HMBA on quail myoblasts transformed with Rous sarcoma virus.
Topics: Acetamides; Animals; Aspirin; Cell Differentiation; Coturnix; Doxorubicin; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Enzymologic; Muscles; Myogenin; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphotyrosine; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1996 |
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Blotting, Western; Chromones; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Sulfatide-induced L-selectin activation generates intracellular oxygen radicals in human neutrophils: modulation by extracellular adenosine.
Topics: Adenosine; Calcium; Enzyme Activation; Free Radicals; Humans; Ionomycin; L-Selectin; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotyrosine; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Respiratory Burst; Sulfoglycosphingolipids; Tetradecanoylphorbol Acetate | 1996 |
Parietal cell MAP kinases: multiple activation pathways.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cyclic AMP; Cytosol; Enzyme Activation; Epidermal Growth Factor; Gastric Mucosa; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parasympathomimetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Tyrosine phosphorylation and subcellular redistribution of p125 ras guanosine triphosphatase-activating protein in human neutrophils stimulated with FMLP.
Topics: Cell Membrane; Concanavalin A; Cytosol; GTPase-Activating Proteins; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Respiratory Burst; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters.
Topics: Adult; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinase 2; Neutrophil Activation; Neutrophils; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate | 1997 |
Extracellular matrix is required for MAP kinase activation and proliferation of rat glomerular epithelial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Extracellular Matrix; Flavonoids; Kidney Glomerulus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Plastics; Rats; Tetradecanoylphorbol Acetate | 1997 |
Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.
Topics: Binding Sites; Calcimycin; Cell Adhesion Molecules; Cell Line; Cytochalasin D; Cytoskeletal Proteins; Egtazic Acid; Humans; Megakaryocytes; Naphthalenes; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proline; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Signal Transduction; Stem Cell Factor; Tetradecanoylphorbol Acetate; TYK2 Kinase | 1997 |
Prostaglandin F2alpha stimulates tyrosine phosphorylation and mitogen-activated protein kinase in osteoblastic MC3T3-E1 cells via protein kinase C activation.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Immunosorbent Techniques; Indoles; Maleimides; Osteoblasts; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate | 1997 |
Protein tyrosine kinase activity regulates nitric oxide synthase induction in rat hepatocytes.
Topics: Animals; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Genistein; Interleukin-1; Isoflavones; Liver; Male; Nitric Oxide Synthase; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways.
Topics: Animals; Antigens; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Cycle Proteins; Cells, Cultured; Enzyme Activation; Enzyme Precursors; GTP-Binding Proteins; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Rats; Syk Kinase; Tetradecanoylphorbol Acetate; Thapsigargin | 1997 |
Newborn and adult CD4+CD45RA+ T-cells express similar tyrosine phosphorylation profiles.
Topics: Adult; Antigens, CD; CD4 Antigens; Fetal Blood; Humans; Immunomagnetic Separation; Infant, Newborn; Leukocyte Common Antigens; Lymphocyte Activation; Muromonab-CD3; Phosphoproteins; Phosphorylation; Phosphotyrosine; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Topics: Androstadienes; Antigens, CD; Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Degranulation; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Tetraspanin 30; Wortmannin | 1997 |
Tyrosine phosphorylation of 100-115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes.
Topics: Blotting, Western; Butanols; Enzyme Activation; Ethanol; Glycerophospholipids; Granulocytes; HL-60 Cells; Humans; Molecular Weight; Oleic Acid; Phosphatidic Acids; Phospholipase D; Phosphorylation; Phosphotyrosine; Propranolol; Proteins; Streptomyces; Tetradecanoylphorbol Acetate | 1997 |
Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin.
Topics: Adjuvants, Immunologic; Bryostatins; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Lactones; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrolides; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cytoplasm; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Macrophages, Peritoneal; Membrane Potentials; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Patch-Clamp Techniques; Phospholipases A; Phospholipases A2; Phosphotyrosine; Proton Pumps; Sodium-Hydrogen Exchangers; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Hydrogen peroxide-induced phospholipase D activation in rat pheochromocytoma PC12 cells: possible involvement of Ca2+-dependent protein tyrosine kinase.
Topics: Animals; Benzoquinones; Blotting, Western; Calcimycin; Calcium; Cinnamates; Enzyme Activation; Enzyme Inhibitors; Genistein; Hydrogen Peroxide; Isoflavones; Lactams, Macrocyclic; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sulfides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Enzyme Induction; Enzyme Precursors; Granulocytes; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Macrophages; Monocytes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Syk Kinase; Tetradecanoylphorbol Acetate; Tretinoin | 1997 |
Pervanadate-induced adhesion of CD4+ T cell to fibronectin is associated with tyrosine phosphorylation of paxillin.
Topics: CD4-Positive T-Lymphocytes; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibronectins; Humans; Lymphocyte Activation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 1997 |
Growth hormone attenuation of epidermal growth factor-induced mitogenesis.
Topics: 3T3 Cells; Animals; Cell Cycle; Cyclin D; Cyclins; DNA; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Human Growth Hormone; Humans; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; S Phase; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.
Topics: B7-1 Antigen; CD28 Antigens; Enzyme Activation; Enzyme Inhibitors; Humans; Jurkat Cells; Ligands; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1997 |
MAP and cdc2 kinase activities at germinal vesicle breakdown in Chaetopterus.
Topics: Animals; Blotting, Western; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Fertilization; Flavonoids; Glycogen Synthase Kinase 3; Ionophores; Kinetin; MAP Kinase Kinase 1; Meiosis; Mitogen-Activated Protein Kinase Kinases; Oocytes; Phosphorylation; Phosphotyrosine; Polychaeta; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Tetradecanoylphorbol Acetate | 1997 |
Neuromedin B receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton.
Topics: Actin Cytoskeleton; Actins; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcimycin; Calcium; Cell Adhesion Molecules; Colchicine; Cytochalasin D; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; GTP-Binding Proteins; Indoles; Maleimides; Mice; Neurokinin B; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Bombesin; rho GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins | 1997 |
Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
Topics: Angiotensin II; Animals; Aorta; Cells, Cultured; Insulin; Insulin Receptor Substrate Proteins; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphoserine; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Receptors, Angiotensin; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Effects of protein tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth.
Topics: Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Female; Insulin; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway.
Topics: Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Carcinoma, Squamous Cell; Enzyme Activation; Enzyme Induction; Genistein; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Phosphotyrosine; Protein Kinase C; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1998 |
Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells.
Topics: Animals; Aorta; Cattle; Cell Membrane; Cells, Cultured; Cytosol; Endothelium, Vascular; Immunoblotting; Immunosorbent Techniques; Lysophosphatidylcholines; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Growth hormone stimulation of the mitogen-activated protein kinase pathway is cell type specific.
Topics: 3T3 Cells; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Human Growth Hormone; Humans; Immunosorbent Techniques; Kinetics; Lymphocytes; Mice; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Inhibition of p130cas tyrosine phosphorylation by calyculin A.
Topics: Cell Aggregation; Crk-Associated Substrate Protein; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Protozoan Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
IgA Fc receptor (CD89) activation enables coupling to syk and Btk tyrosine kinase pathways: differential signaling after IFN-gamma or phorbol ester stimulation.
Topics: Agammaglobulinaemia Tyrosine Kinase; Antigens, CD; Cells, Cultured; Enzyme Activation; Enzyme Precursors; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Macromolecular Substances; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fc; Signal Transduction; Syk Kinase; Tetradecanoylphorbol Acetate | 1998 |
Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein.
Topics: Amino Acid Substitution; Antigens, CD; Binding Sites; CD2 Antigens; CD28 Antigens; Cell Adhesion; Flow Cytometry; Green Fluorescent Proteins; HL-60 Cells; Humans; Integrin beta1; Kinetics; Luminescent Proteins; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Ubiquitin-Protein Ligases | 1998 |
Tyrosine phosphorylation of paxillin/pp125FAK and microvascular endothelial barrier function.
Topics: Animals; Arsenicals; Capillary Permeability; Cattle; Cell Adhesion Molecules; Coronary Circulation; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histamine; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, Insulin; Swine; Tetradecanoylphorbol Acetate; Venules | 1998 |
Bradykinin stimulates the ERK-->Elk-1-->Fos/AP-1 pathway in mesangial cells.
Topics: Animals; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Glomerular Mesangium; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors | 1998 |
Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells.
Topics: Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Humans; Kidney; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Carbachol; Cell Adhesion Molecules; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Humans; Neuroblastoma; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, Muscarinic M3; Receptors, Muscarinic; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages.
Topics: Acetylation; Animals; Azepines; Cell Line; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Genistein; Lysophosphatidylcholines; Lysophospholipids; Macrophages, Peritoneal; Mice; Phosphatidic Acids; Phospholipase D; Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Second Messenger Systems; Tetradecanoylphorbol Acetate; Triazoles | 1999 |
Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology.
Topics: Adult; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Cytokines; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Milk Proteins; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotyrosine; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Superoxides; Tetradecanoylphorbol Acetate; Trans-Activators | 1999 |
Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate.
Topics: Androstadienes; Animals; Arsenicals; Cell Adhesion Molecules; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Myosin-Light-Chain Kinase; Neuroblastoma; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, Cholinergic; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH.
Topics: Animals; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Bacterial Outer Membrane Proteins; Calcium; Cell Line; Interleukin-2; Ionomycin; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Transgenic; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Up-Regulation; Yersinia pseudotuberculosis Infections | 1999 |
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Topics: Actins; Arsenicals; Cell Adhesion Molecules; Cell Movement; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Glioma; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1999 |
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Kidney; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Opossums; Parathyroid Hormone; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1999 |
Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
Topics: Antigens, CD; CD28 Antigens; Cell Adhesion Molecules; Cells, Cultured; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Jurkat Cells; Kinetics; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Vanadates | 2000 |
Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells.
Topics: Animals; Apoptosis; Catalysis; Cell Differentiation; Cell Division; DNA Replication; Enzyme Activation; Enzyme Induction; Interleukin-3; Isoenzymes; Janus Kinase 2; Macrophages; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes.
Topics: Acetylcysteine; Animals; Antioxidants; CD4 Antigens; CD8 Antigens; Cells, Cultured; Concanavalin A; Enzyme Inhibitors; Kinetics; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Onium Compounds; Phosphorylation; Phosphotyrosine; Reactive Oxygen Species; Receptor-CD3 Complex, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2000 |
Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.
Topics: Calcineurin; Calcium Signaling; DNA-Binding Proteins; Enzyme Activation; Gene Expression; Genes, Reporter; Humans; Hydrolysis; Isoenzymes; Jurkat Cells; Muromonab-CD3; NFATC Transcription Factors; Nuclear Proteins; Oncogene Protein v-cbl; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; ras Proteins; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Type C Phospholipases; Ubiquitin-Protein Ligases | 2000 |
Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Blood Platelets; Calcium; Cytoskeleton; Edetic Acid; Fibrinogen; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Humans; Oligopeptides; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Kinase C; Protein Transport; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tetradecanoylphorbol Acetate; Thrombin | 2000 |
Activation of signal transduction pathways involving trkA, PLCgamma-1, PKC isoforms and ERK-1/2 by tetanus toxin.
Topics: Animals; Biological Transport; Brain; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, trkA; Signal Transduction; Solubility; Synaptosomes; Tetanus Toxin; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2000 |
Regulation by ceramide of epidermal growth factor signal transduction and mitogenesis in cell lines overexpressing the growth factor receptor.
Topics: Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Ceramides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Mitogens; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2000 |
Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.
Topics: 1-Butanol; Cells, Cultured; Ethanol; Glycerophospholipids; Humans; Neutrophils; Phosphatidic Acids; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate | 2001 |
Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cytochalasin B; Enzyme Inhibitors; Fibrinogen; Genistein; Glutathione Transferase; Humans; In Vitro Techniques; Interleukin-8; Kinetics; Macrophage-1 Antigen; Neutrophil Activation; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; src Homology Domains; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Carbachol stimulates TYR phosphorylation and association of PKCdelta and PYK2 in pancreas.
Topics: Animals; Carbachol; Cells, Cultured; Focal Adhesion Kinase 2; Isoenzymes; Macromolecular Substances; Muscarinic Agonists; Pancreas; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 2001 |
Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2.
Topics: Animals; Base Sequence; beta-Adrenergic Receptor Kinases; Cell Line; Cricetinae; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Fibroblasts; Green Fluorescent Proteins; Humans; Immediate-Early Proteins; Kidney; Kinetics; Luminescent Proteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Polymerase Chain Reaction; Protein Kinase C; Protein Transport; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 2002 |
Alpha-tocopherol modulates tyrosine phosphorylation in human neutrophils by inhibition of protein kinase C activity and activation of tyrosine phosphatases.
Topics: alpha-Tocopherol; Chromans; Enzyme Activation; Humans; Immunoblotting; Neutrophils; Oxidants; Ozone; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate | 2001 |
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Biological Transport; Cell Nucleus; COS Cells; Cytoplasm; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescent Antibody Technique; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Microscopy, Confocal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2002 |
Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini.
Topics: Animals; Binding Sites; Calcium; Cholecystokinin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Hydrolysis; Indoles; Inositol Phosphates; Kinetics; Male; Maleimides; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases | 2003 |
Focal adhesion kinase is required for endothelin-induced cell cycle progression of cultured astrocytes.
Topics: Actins; Amphetamine; Amphetamines; Animals; Animals, Newborn; Astrocytes; Bromodeoxyuridine; Cell Cycle; Cells, Cultured; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genetic Vectors; Mutation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Transfection | 2003 |
Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells.
Topics: Animals; Cell Fractionation; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Activation; Enzyme Inhibitors; Kinetics; Male; Pancreas; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Rats; Rats, Wistar; Sincalide; src-Family Kinases; Tetradecanoylphorbol Acetate; Tyrphostins | 2003 |
Effect of phosphotyrosine proteins on phorbol myristate acetate-induced NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes.
Topics: Animals; Enzyme Activation; Female; Free Radicals; Guinea Pigs; NADPH Oxidases; Neutrophils; Peritoneal Cavity; Phosphotyrosine; Proteins; Tetradecanoylphorbol Acetate | 2003 |
Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line, Tumor; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Insulin; Insulin Receptor Substrate Proteins; Ionomycin; Mitogen-Activated Protein Kinases; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Muscarinic; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2004 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes.
Topics: Actin Cytoskeleton; Actins; Asthma; Cell Adhesion; Cell Membrane Structures; Cytoskeletal Proteins; Disintegrins; Eosinophils; Fibroblasts; Gelsolin; Humans; Integrin alpha4beta1; Interleukin-5; Macrophages; Matrix Metalloproteinase 8; Osteoclasts; Paxillin; Phenanthrolines; Phosphoproteins; Phosphotyrosine; Rhinitis; Talin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vinculin | 2004 |
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
Topics: 3T3 Cells; Alanine; Animals; Butadienes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Janus Kinase 2; MAP Kinase Kinase 1; Mass Spectrometry; Mice; Mutation; Nitriles; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Repressor Proteins; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts.
Topics: Bradykinin; Calcium; Calcium Channels; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Econazole; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Nitric Oxide; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 2006 |
CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways.
Topics: Animals; Bombesin; Calcium; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Enzyme Activation; Growth Substances; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Pancreas, Exocrine; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein Kinase C-delta; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 2007 |
PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.
Topics: Animals; Astrocytes; Brain; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Inflammation; Interferon-gamma; Janus Kinases; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Sprague-Dawley; Response Elements; STAT3 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Tetradecanoylphorbol Acetate | 2007 |
Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.
Topics: Actins; Cell Membrane; Cell Movement; Crk-Associated Substrate Protein; Enzyme Activation; Focal Adhesions; Glioblastoma; Phosphotyrosine; Protein Kinase C; Protein Transport; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins pp60(c-src); Pseudopodia; rac1 GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate | 2007 |
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.
Topics: Catalysis; Cytoskeletal Proteins; Endothelial Cells; HCT116 Cells; Humans; Mutant Proteins; Neoplasm Proteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Tyrosine Phosphatases; RNA Interference; Substrate Specificity; Tetradecanoylphorbol Acetate | 2008 |
The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97.
Topics: Adenosine Triphosphatases; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Phosphotyrosine; RNA Interference; RNA, Messenger; RNA, Small Interfering; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transfection; U937 Cells; Valosin Containing Protein | 2008 |
Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells.
Topics: Actins; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Nucleus Shape; Cell Shape; Cytoskeleton; Gene Silencing; Humans; Leukemia, Promyelocytic, Acute; Macrophages; Monocytes; Phenotype; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-vav; Tetradecanoylphorbol Acetate; Up-Regulation | 2011 |
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.
Topics: Amino Acid Sequence; Animals; Binding Sites; Class Ia Phosphatidylinositol 3-Kinase; Enzyme Activation; Enzyme Activators; HEK293 Cells; Humans; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Binding; Protein Kinase C; Protein Multimerization; Signal Transduction; src Homology Domains; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.
Topics: Bradykinin; Cell Line, Tumor; Cell Membrane; Diacylglycerol Kinase; Endosomes; Enzyme Activation; ErbB Receptors; Gene Silencing; Green Fluorescent Proteins; HEK293 Cells; Humans; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Binding; Protein Kinase C; Protein Transport; Tetradecanoylphorbol Acetate; Uridine Triphosphate | 2012 |
Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody.
Topics: Animals; Antibodies, Phospho-Specific; Antibody Specificity; Cell Nucleus; Green Fluorescent Proteins; Humans; Interleukin-6; Lipopolysaccharides; Liver; Mice; Mitochondria; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Transport; Proto-Oncogene Proteins c-fos; Single-Chain Antibodies; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2014 |
Protein kinase C regulates ErbB3 turnover.
Topics: Carbazoles; Cell Membrane; Endocytosis; Enzyme Activation; Humans; Lysosomes; MCF-7 Cells; Neuregulin-1; Phosphorylation; Phosphotyrosine; Protein Kinase C-delta; Protein Kinase Inhibitors; Protein Stability; Protein Transport; Proteolysis; Receptor, ErbB-3; Tetradecanoylphorbol Acetate; Ubiquitination | 2019 |
P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK.
Topics: A549 Cells; Animals; Cell Movement; Cell Proliferation; Humans; Mice; NADPH Oxidases; Phosphorylation; Phosphotyrosine; RAW 264.7 Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate | 2020 |