phosphotyrosine has been researched along with paxilline in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 75 (48.70) | 18.2507 |
| 2000's | 65 (42.21) | 29.6817 |
| 2010's | 13 (8.44) | 24.3611 |
| 2020's | 1 (0.65) | 2.80 |
| Authors | Studies |
|---|---|
| Burridge, K; Romer, LH; Turner, CE | 1 |
| Turner, CE | 2 |
| Chang, P; Greenberg, S; Silverstein, SC | 1 |
| Birge, RB; Fajardo, JE; Glassman, R; Hanafusa, H; Hempstead, BL; Kraemer, R; Mahadeo, D | 1 |
| Rozengurt, E; Seufferlein, T | 3 |
| Hanafusa, H; Hata, A; Nakagawa, H; Okada, M; Sabe, H | 1 |
| Morii, N; Narumiya, S; Rankin, S; Rozengurt, E | 1 |
| Anderson, DC; Brown, EJ; Graham, IL; Holers, VM | 1 |
| Miller, JT; Turner, CE | 1 |
| Charonis, AS; Hasegawa, G; Hunter, AJ | 1 |
| Adam, LP; Gunst, SJ; Pavalko, FM; Walker, TL; Wu, MF | 1 |
| Hall, A; Nobes, CD | 1 |
| Khan, MA; Kobayashi, S; Nakagawa, H; Okada, M; Okumura, N | 1 |
| Molloy, CJ; Pietras, KM; Taylor, DS; Turner, CE | 1 |
| Abedi, H; Dawes, KE; Zachary, I | 1 |
| Corvaia, N; Coutant, KD; Ryder, NS | 1 |
| Birge, RB; Cantley, LC; Fajardo, JE; Hanafusa, H; Reichman, C; Shoelson, SE; Songyang, Z | 1 |
| Akedo, H; Imamura, F; Iwasaki, T; Komagome, R; Mukai, M; Shinkai, K; Yoshioka, K | 1 |
| Fuortes, M; Jin, W; Nathan, C | 1 |
| Aznavoorian, S; Liotta, LA; McClanahan, J; Parsons, J; Stracke, ML | 1 |
| Claesson-Welsh, L; Hooshmand-Rad, R; Rankin, S; Rozengurt, E | 1 |
| Narumiya, S; Saito, Y; Sumpio, BE; Yano, Y | 1 |
| Fujiwara, K; Kano, Y; Katoh, K; Masuda, M | 1 |
| Aderem, A; Allen, LA | 1 |
| Geibel, J; Sumpio, BE; Yano, Y | 1 |
| Maassen, JA; Mikkers, HM; Ouwens, DM; Stein-Gerlach, M; Ullrich, A; van der Zon, GC | 1 |
| Gunst, SJ; Pavalko, FM; Wang, Z | 1 |
| Lee, KM; Villereal, ML | 1 |
| Distler, A; Haller, H; Kunzendorf, U; Lindschau, C; Luft, FC; Sacherer, K; Walz, G | 1 |
| Avraham, H; Avraham, S; Druker, B; Ganju, RK; Groopman, JE; Hatch, WC; Ona, MA | 1 |
| Avraham, H; Avraham, S; Fu, Y; Hiregowdara, D; London, R | 1 |
| Canbay, E; Goffin, V; Kilic, E; Norman, M; Zachary, I | 1 |
| Bellis, SL; Curtis, MS; Perrotta, JA; Turner, CE | 1 |
| Bhalla, RC; Fang, S; Sharma, RV | 1 |
| Aprikian, AG; Chevalier, S; Han, K; Tremblay, L | 1 |
| Bannerman, DD; Goldblum, SE | 1 |
| Hershkoviz, R; Kachalsky, SG; Lider, O; Miron, S | 1 |
| Avraham, S; Ganju, RK; Groopman, JE; Liu, ZY; Schweitzer, K; Wang, JF; Weksler, B | 1 |
| Sasaki, T; Schaller, MD | 1 |
| Adams, JC | 1 |
| Adler, G; Gaisano, HY; Lutz, MP; Piiper, A; Stryjek-Kaminska, D; Zeuzem, S | 1 |
| Epstein, DL; Harding, TW; Kinch, M; O'Brien, ET | 1 |
| Arendt, CW; Berg, NN; Lou, O; Ostergaard, HL | 1 |
| Hocking, DC; McKeown-Longo, PJ; Sottile, J | 1 |
| Chambaz, EM; Chinn, A; Feige, JJ; Gaillard, I; Vilgrain, I | 1 |
| Needham, LK; Rozengurt, E | 1 |
| Chang, BT; Chenn, A; McConnell, SK; Zhang, YA | 1 |
| Burridge, K; Gilmore, AP; Lohse, DL; Romer, LH; Schneider, GB | 1 |
| Hawker, J; Huang, Q; Meng, FY; Wu, HM; Yuan, Y | 1 |
| Hamaguchi, M; Naruse, K; Sai, XR; Sokabe, M; Yamada, T | 1 |
| Casamassima, A; Rozengurt, E | 1 |
| Black, DS; Bliska, JB; Montagna, LG; Zitsmann, S | 1 |
| Goldblum, SE; Wang, P; Young, BA | 1 |
| Moolenaar, WH; Ramakers, GJ | 1 |
| Andrieu, V; Da Costa, L; Franzini, E; Gozin, A; Pasquier, C; Rollet-Labelle, E | 1 |
| Bartholomew, PJ; DePasquale, JA; Vinci, JM | 1 |
| Grgurevich, S; McVicar, DW; Mikhael, A | 1 |
| Makino, H; Matsuda, M; Shikata, K; Shikata, Y; Sugimoto, H; Wada, J | 1 |
| Berezin, V; Bock, E; Kawa, A; Skladchikova, G; Walmod, PS | 1 |
| Dougher, M; Terman, BI | 1 |
| Koukouritaki, SB; Lianos, EA | 1 |
| Haydar, SA; Kuphal, R; Lightfoot, JD; Salant, DJ; Topham, PS | 1 |
| Atkinson, J; Johannsen, M; Manski, D; Riecken, EO; Rühl, M; Sahin, E; Schuppan, D; Somasundaram, R | 1 |
| Guvakova, MA; Surmacz, E | 1 |
| Kadowaki, T; Nagai, R; Sabe, H; Seko, Y; Takahashi, N; Tobe, K | 1 |
| Baron, R; Hernandez-Lagunas, L; Horne, WC; Zhang, Z | 1 |
| Hildebrand, JD; Parsons, JT; Schaller, MD | 1 |
| Fukuhara, S; Gutkind, JS; Igishi, T; Katz, BZ; Patel, V; Yamada, KM | 1 |
| Carbajal, JM; Schaeffer, RC | 1 |
| Chang, JS; Iwashita, S; Kim, MJ; Lee, YH; Ryu, SH; Suh, PG | 1 |
| Maruyama, T; Sabe, H; Yoshimura, Y | 1 |
| Minneman, KP; Zhong, H | 1 |
| Reber, BF; Schindelholz, B | 1 |
| García, LJ; Rosado, JA; Salido, GM | 1 |
| Aoto, H; Ishino, M; Sasaki, T; Sasaski, H; Suzuki, R | 1 |
| Lokeshwar, VB; Selzer, MG | 1 |
| Chung, HT; Jeong, SM; Kim, KS; Kim, PH; Lee, JH; Ryu, H | 1 |
| Belisario, MA; Della Morte, R; Derkinderen, P; Di Natale, P; Garbi, C; Girault, JA; Nitsch, L; Squillacioti, C; Staiano, N | 1 |
| da Costa, SR; Hamm-Alvarez, SF; Schönthal, AH; Vilalta, PM; Wang, Y | 1 |
| Dedhar, S; Mulholland, DJ; Vogl, AW | 1 |
| Kamikura, DM; Lamorte, L; Park, M | 1 |
| Groopman, JE; Matczak, E; Proper, JA; Wang, JF; Zhang, XF | 1 |
| Leopoldt, D; Rozengurt, E; Yee, HF | 1 |
| Nissim, I; Roeser, NF; Senter, RA; Venkatachalam, MA; Weinberg, JM | 1 |
| Leopoldt, D; Lunn, JA; Rozengurt, E; Sinnett-Smith, J | 1 |
| Guan, JL; Shen, TL | 1 |
| Brandt, CR; Cai, S; Fauss, DJ; Geiger, B; Glasser, A; Kaufman, PL; Liu, X; Polansky, JR; Volberg, T | 1 |
| Hadjiargyrou, M; McLeod, KJ; Rubin, CT; Sommerfeldt, DW | 1 |
| Alonso, A; Kabsch, K; Kohl, A; Komposch, G; Molina, T; Tomakidi, P | 1 |
| Akedo, H; Iwasaki, T; Kakishita, E; Mukai, M; Nakata, A; Sabe, H; Schaefer, E; Shinkai, K; Tatsuta, M; Terada, N; Tsujimura, T; Yano, H | 1 |
| Bohl, J; Vande Pol, S; Wade, R | 1 |
| Houliston, RA; Keogh, RJ; Wheeler-Jones, CP | 1 |
| Haier, J; Nicolson, GL | 1 |
| Miyasaka, M; Murata, S; Tanaka, T | 1 |
| Joo, CK; Kim, JT | 1 |
| Fukai, F; Goto, S; Ishikawa, T; Kamiya, S; Katayama, T; Kato, R; Nakamura, H; Oguma, F; Ueki, M | 1 |
| Jackson, JL; Young, MR | 2 |
| Li, M; Sakaguchi, DS | 1 |
| Liu, SW; Meisinger, J; Young, MR | 1 |
| Gelman, IH | 1 |
| Ceacareanu, AC; Hassid, A; Lin, Y | 1 |
| Ginsberg, MH; Goldfinger, LE; Han, J; Rose, DM; Woodside, DG | 1 |
| Newman, WH; Wang, Z | 1 |
| Ballestrem, C; Geiger, B; Kam, Z; Zaidel-Bar, R | 1 |
| Andreolotti, AG; Bragado, MJ; Garcia-Marin, LJ; Jensen, RT; Tapia, JA | 1 |
| Jove, R; Mei, L; Meng, S; Ren, Y; Wu, J; Zhao, ZJ | 1 |
| Chuang, YC; Huang, CC; Leu, TH; Maa, MC; Su, SL; Yeh, HH | 1 |
| Claesson-Welsh, L; Cross, MJ; Hägerkvist, R; Holmqvist, K; Matsumoto, T; Rahimi, N; Rolny, C; Welsh, M | 1 |
| Geiger, B; Volberg, T; Zimerman, B | 1 |
| Annis, DS; Barthel, SR; Duffy, AK; Johansson, MW; Lye, MH; Mosher, DF | 1 |
| Ballestrem, C; Geiger, B; Iyer, VV; Kirchner, J; Schaller, MD | 1 |
| de la Blanca, EP; Jiménez, E; Montiel, M | 1 |
| Healy, NC; Huigsloot, M; Kedersha, NL; Kiely, PA; Loughran, G; O'Connor, R | 1 |
| Enns, A; Fisch, KM; Gassmann, P; Haier, J; Nicolson, GL; von Sengbusch, A | 1 |
| Chiariotti, L; Florio, T; Fusco, A; Iuliano, R; Pera, IL; Santoro, M; Schettini, G; Susini, C; Trapasso, F; Viglietto, G | 1 |
| Azuma, K; Inoue, S; Ouchi, Y; Sakai, R; Tanaka, M; Uekita, T; Yokota, J | 1 |
| Marcoux, N; Vuori, K | 1 |
| Vande Pol, S; Wade, R | 1 |
| Cave, CM; Lentsch, AB; Matlin, K; Robinson, CT; Solomkin, JS; Umanskiy, K; Williams, MA | 1 |
| Chung, E; Kim, S; Kim, YB; Kim, YT; Lee, JW; Lee, MS; Lee, SY | 1 |
| Altankov, G; Hristova, K; Momchilova, A; Pankov, R; Stephanova, E; Valtcheva-Sarker, R | 1 |
| Casanova, JE; Shi, J | 1 |
| Newman, DK; Newman, PJ; Okada, M; Rathore, VB | 1 |
| Imperiali, B; Vogel, EM | 1 |
| Doan, AT; Huttenlocher, A | 1 |
| Day, RM; Kayyali, US; Lechleider, RJ; Lee, YH; Rajan, T; Sousa, AM | 1 |
| Chapman, KE; Desai, LP; Hassid, A; Sinclair, SE; Waters, CM | 1 |
| Boyce, T; Clack, G; Duffield, E; Fennell, M; Green, T; Jacobs, V; Jones, RJ; Kelly, J; Pinto, F; Robertson, J | 1 |
| Albigès-Rizo, C; Badowski, C; Block, MR; Chabadel, A; Grichine, A; Jurdic, P; Oddou, C; Pawlak, G; Pfaff, M | 1 |
| Furukawa, K; Hamamura, K; Miyazaki, S; Nakashima, H; Ohkawa, Y; Tsuji, M; Ueda, M; Urano, T; Yamamoto, N | 1 |
| Berrier, AL; Jones, CW; LaFlamme, SE | 1 |
| Discher, DE; Tsai, RK | 1 |
| Avruch, J; Czech, MP; Hagan, GN; Lin, Y; Magnuson, MA | 1 |
| Baker, MW; Macagno, ER; Peterson, SM | 1 |
| Ge, BX; Huang, Z; Yan, DP | 1 |
| Mayer, BJ; Sharma, A | 1 |
| Saldaña, L; Vilaboa, N | 1 |
| Choi, CK; Digman, MA; Gratton, E; Horwitz, AR; Zareno, J | 1 |
| Brown, C; Morham, SG; Naghavi, MH; Walsh, D | 1 |
| Gomez, TM; Myers, JP | 1 |
| Chen, SY; Chiu, HY; Jwo, SC; Lee, MY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC; Wang, HH | 1 |
| Arellano-Sánchez, N; Bartolomé, RA; Coló, GP; Hernández-Varas, P; Lock, J; Strömblad, S; Teixidó, J | 1 |
| Bose, R; Boyer, AP; Collier, TS; Vidavsky, I | 1 |
| Akita, K; Furukawa, K; Hamamura, K; Matsumoto, Y; Nakada, H; Okajima, T; Tsuchida, A; Urano, T; Zhang, Q | 1 |
| Beckerle, MC; Blankman, E; Deakin, NO; Hoffman, LM; Jensen, CC; Smith, MA; Turner, CE | 1 |
| Baird, B; Bryant, KL; Hammes, SR; Holowka, D; Singhai, A; Wakefield, DL | 1 |
| Deng, XL; Li, GR; Liu, YG; She, G; Song, Z; Sun, HY; Wang, Y; Xiao, GS | 1 |
| Atherton, P; Ballestrem, C; Stutchbury, B; Tsang, R; Wang, DY | 1 |
| Deng, Y; Ding, Q; He, K; Li, H; Mu, G; Wu, L; Xu, M; Yang, D; Yu, H; Zhang, L; Zhou, J | 1 |
| Tang, DD; Wang, R; Wang, Y | 1 |
1 review(s) available for phosphotyrosine and paxilline
| Article | Year |
|---|---|
Paxillin: a cytoskeletal target for tyrosine kinases.
Topics: Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Embryonic and Fetal Development; Extracellular Matrix; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinculin | 1994 |
153 other study(ies) available for phosphotyrosine and paxilline
| Article | Year |
|---|---|
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
Topics: 3T3 Cells; Animals; Benzoquinones; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Lactams, Macrocyclic; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1992 |
Paxillin is a major phosphotyrosine-containing protein during embryonic development.
Topics: Animals; Chick Embryo; Cytoskeletal Proteins; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Tissue Distribution; Tyrosine | 1991 |
Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.
Topics: Actins; Animals; Chromatography, Affinity; Cytochalasin D; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Macromolecular Substances; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Weight; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Tyrosine | 1994 |
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin; Membrane Proteins; Molecular Weight; Nerve Growth Factors; Neurons; Oncogene Protein v-crk; Paxillin; PC12 Cells; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, Nerve Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1994 |
Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1994 |
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
Topics: Animals; Base Sequence; Cell Adhesion Molecules; Cell Line; Chick Embryo; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; DNA Primers; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; src-Family Kinases; Structure-Activity Relationship; Tyrosine | 1994 |
Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin.
Topics: 3T3 Cells; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Base Sequence; Bombesin; Botulinum Toxins; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Mice; Molecular Sequence Data; Molecular Weight; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; rho GTP-Binding Proteins; Signal Transduction; Tyrosine | 1994 |
Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Junctions; Mice; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Terpenes; Thapsigargin; Tyrosine | 1994 |
Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.
Topics: Adolescent; Adult; CD18 Antigens; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Extracellular Matrix Proteins; Female; Humans; In Vitro Techniques; Integrins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Complement; Signal Transduction; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Adhesion Molecules; Chick Embryo; Consensus Sequence; Cytoskeletal Proteins; DNA, Complementary; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes; Microscopy, Fluorescence; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Vinculin | 1994 |
Matrix nonenzymatic glycosylation leads to altered cellular phenotype and intracellular tyrosine phosphorylation.
Topics: Animals; Basement Membrane; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycosylation; Humans; Kinetics; Mice; Mice, Inbred BALB C; Microcirculation; Neoplasms, Experimental; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Skin; Tyrosine | 1995 |
Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction.
Topics: Acetylcholine; Animals; Binding Sites; Cytoskeletal Proteins; Dogs; Immunosorbent Techniques; Muscle Contraction; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Talin; Trachea; Tyrosine; Vinculin | 1995 |
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.
Topics: 3T3 Cells; Actins; Animals; cdc42 GTP-Binding Protein, Saccharomyces cerevisiae; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Fungal Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; Membrane Proteins; Mice; Microinjections; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pseudopodia; rac GTP-Binding Proteins; Recombinant Fusion Proteins; rhoB GTP-Binding Protein; Signal Transduction; Tyrosine; Vinculin | 1995 |
Nerve growth factor stimulates tyrosine phosphorylation of paxillin in PC12h cells.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Immunosorbent Techniques; Kinetics; Nerve Growth Factors; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Signal Transduction; Tyrosine | 1995 |
Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Becaplermin; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1995 |
Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Actins; Animals; Aorta; Becaplermin; Cell Adhesion Molecules; Cell Division; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kinetics; Mice; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Receptor, Insulin; Recombinant Proteins; Tunica Media; Tyrosine | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway.
Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Blotting, Western; Bombesin; Botulinum Toxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Indoles; Kinetics; Maleimides; Mice; Microinjections; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylcholine; Phosphotyrosine; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Signal Transduction; Sphingosine | 1995 |
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Blotting, Western; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Oncogene Protein v-crk; Oncogenes; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Binding; Recombinant Fusion Proteins; Retroviridae Proteins, Oncogenic; Tyrosine; Vanadates | 1993 |
rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion.
Topics: Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; GTP-Binding Proteins; Isoflavones; Liver Neoplasms, Experimental; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Signal Transduction; Tumor Cells, Cultured | 1996 |
Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor.
Topics: Adult; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Ceramides; Cytoskeletal Proteins; Drug Administration Schedule; Humans; Neutrophil Activation; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Respiratory Burst; Sphingomyelin Phosphodiesterase; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways.
Topics: Amino Acid Sequence; Antibodies; Cell Adhesion; Cell Line; Cell Movement; Chemotaxis; Cytoskeletal Proteins; Extracellular Matrix Proteins; GTP-Binding Proteins; Humans; Kinetics; Melanoma; Oligopeptides; Paxillin; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Vitronectin; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella; Vitronectin | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Aorta, Thoracic; Botulinum Toxins; Cattle; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Mitomycins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Stress, Mechanical | 1996 |
Mutually exclusive distribution of the focal adhesion associated proteins and the erythrocyte membrane skeleton proteins in the human fibroblast plasma membrane undercoat.
Topics: Actin Cytoskeleton; Ankyrins; Carrier Proteins; Cell Adhesion; Cell Adhesion Molecules; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cytoskeletal Proteins; Erythrocyte Membrane; Fibronectins; Humans; Male; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphotyrosine; Receptors, Fibronectin; Receptors, Vitronectin; Spectrin; Talin; Vinculin | 1996 |
Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.
Topics: Actinin; Actins; Animals; CD18 Antigens; Complement System Proteins; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; Immunoglobulin G; Macrophage-1 Antigen; Macrophages, Peritoneal; Mice; Mice, Inbred Strains; Paxillin; Phagocytosis; Phagosomes; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fc; Vinculin | 1996 |
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.
Topics: Animals; Aorta; Cattle; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Isoflavones; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Stress, Mechanical; Tissue Distribution; Tyrosine; Tyrphostins | 1996 |
Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D.
Topics: 3T3 Cells; Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Mice; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Transfection | 1996 |
Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction.
Topics: Acetylcholine; Analysis of Variance; Animals; Blotting, Western; Cytoskeletal Proteins; Dogs; Genistein; In Vitro Techniques; Isoflavones; Isometric Contraction; Kinetics; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Serotonin; Trachea; Tyrosine | 1996 |
Tyrosine phosphorylation and activation of pp60c-src and pp125FAK in bradykinin-stimulated fibroblasts.
Topics: Bradykinin; Cell Adhesion Molecules; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oncogene Protein pp60(v-src); Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Time Factors; Tyrosine | 1996 |
T cell adhesion to P-selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; COS Cells; Cytoskeletal Proteins; E-Selectin; Fluorescent Antibody Technique, Indirect; Focal Adhesion Protein-Tyrosine Kinases; Molecular Weight; Oligosaccharides; P-Selectin; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Sialyl Lewis X Antigen; Signal Transduction; T-Lymphocytes; Time Factors | 1997 |
RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.
Topics: Adaptor Proteins, Signal Transducing; Calcium; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 2; GRB2 Adaptor Protein; Humans; Kinetics; Lymphocyte Activation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, Antigen, T-Cell; Signal Transduction; src Homology Domains; T-Lymphocytes | 1997 |
Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.
Topics: Binding Sites; Calcimycin; Cell Adhesion Molecules; Cell Line; Cytochalasin D; Cytoskeletal Proteins; Egtazic Acid; Humans; Megakaryocytes; Naphthalenes; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proline; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Signal Transduction; Stem Cell Factor; Tetradecanoylphorbol Acetate; TYK2 Kinase | 1997 |
Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells.
Topics: Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Janus Kinase 2; Kinetics; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Tumor Cells, Cultured | 1997 |
Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Muscle, Smooth; Mutagenesis, Site-Directed; Paxillin; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Fusion Proteins | 1997 |
Endothelial nitric oxide synthase gene transfer inhibits platelet-derived growth factor-BB stimulated focal adhesion kinase and paxillin phosphorylation in vascular smooth muscle cells.
Topics: Animals; Becaplermin; Cell Adhesion Molecules; Cell Division; Cell Movement; Coronary Vessels; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Gene Transfer Techniques; Guinea Pigs; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis | 1997 |
Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.
Topics: Bombesin; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosorbent Techniques; Integrins; Male; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphotyrosine; Prostatic Neoplasms; Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured | 1997 |
Endotoxin induces endothelial barrier dysfunction through protein tyrosine phosphorylation.
Topics: Animals; Benzoquinones; Biological Transport; Cattle; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Endotoxins; Enzyme Inhibitors; Escherichia coli; Genistein; Isoflavones; Lactams, Macrocyclic; Lipopolysaccharides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pulmonary Artery; Quinones; Rifabutin; Serum Albumin, Bovine; Vanadates | 1997 |
Pervanadate-induced adhesion of CD4+ T cell to fibronectin is associated with tyrosine phosphorylation of paxillin.
Topics: CD4-Positive T-Lymphocytes; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibronectins; Humans; Lymphocyte Activation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 1997 |
Characterization of signal transduction pathways in human bone marrow endothelial cells.
Topics: Bone Marrow; Bone Marrow Cells; Carrier Proteins; Cytoskeletal Proteins; Endothelial Growth Factors; Endothelium; Enzyme Activation; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 2; Humans; JNK Mitogen-Activated Protein Kinases; Lymphokines; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Oncostatin M; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor B; Vascular Endothelial Growth Factor Receptor-3; Vascular Endothelial Growth Factors | 1997 |
Differential signaling by the focal adhesion kinase and cell adhesion kinase beta.
Topics: Animals; Binding Sites; Cell Adhesion Molecules; Chick Embryo; Crk-Associated Substrate Protein; Cytoskeletal Proteins; DNA Primers; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Microfilament Proteins; Paxillin; Phosphoproteins; Phosphotyrosine; Polymerase Chain Reaction; Protein Engineering; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tensins; Vanadates | 1997 |
Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes.
Topics: Actins; Animals; Blood Platelets; Carrier Proteins; Cell Adhesion; Cell Line; Cell Movement; Chondroitin Sulfates; Cytoskeletal Proteins; Dogs; Extracellular Matrix; Extracellular Matrix Proteins; Humans; Integrins; Mice; Microfilament Proteins; Oligopeptides; Paxillin; Phosphoproteins; Phosphotyrosine; Rats; Thrombospondin 1 | 1997 |
Protein tyrosine phosphorylation in pancreatic acini: differential effects of VIP and CCK.
Topics: Animals; Bucladesine; Cells, Cultured; Colforsin; Cytoskeletal Proteins; Kinetics; Molecular Weight; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptors, Cholecystokinin; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide | 1997 |
A mechanism for trabecular meshwork cell retraction: ethacrynic acid initiates the dephosphorylation of focal adhesion proteins.
Topics: Actins; Animals; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Colchicine; Cytoskeletal Proteins; Endothelium, Vascular; Ethacrynic Acid; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pulmonary Artery; Trabecular Meshwork | 1997 |
Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells.
Topics: Animals; Antibodies; CD3 Complex; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 2; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Organophosphates; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; src Homology Domains; T-Lymphocytes, Cytotoxic | 1998 |
Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Movement; Cycloheximide; Cytochalasin D; Cytoskeletal Proteins; Extracellular Matrix; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intercellular Junctions; Kinetics; Male; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fibronectin; Recombinant Proteins; Signal Transduction; Skin | 1998 |
Hormonal regulation of focal adhesions in bovine adrenocortical cells: induction of paxillin dephosphorylation by adrenocorticotropic hormone.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cattle; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Colforsin; CSK Tyrosine-Protein Kinase; Cyclic AMP; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunohistochemistry; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine; Vanadates | 1998 |
Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate.
Topics: Actins; ADP Ribose Transferases; Botulinum Toxins; Cell Adhesion Molecules; Cell Line; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; rho-Associated Kinases; Signal Transduction; Thrombin; Transfection | 1998 |
Intrinsic polarity of mammalian neuroepithelial cells.
Topics: Actin Cytoskeleton; Actins; Animals; beta Catenin; Cadherins; Cell Adhesion Molecules; Cell Polarity; Cerebral Ventricles; Cytoskeletal Proteins; Epithelial Cells; Ferrets; Fetal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Junctions; Microtubules; Mitosis; Nerve Tissue Proteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Signal Transduction; Telencephalon; Trans-Activators; Tubulin | 1998 |
Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Microinjections; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Stress, Mechanical; Tyrosine | 1998 |
Tyrosine phosphorylation of paxillin/pp125FAK and microvascular endothelial barrier function.
Topics: Animals; Arsenicals; Capillary Permeability; Cattle; Cell Adhesion Molecules; Coronary Circulation; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histamine; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor, Insulin; Swine; Tetradecanoylphorbol Acetate; Venules | 1998 |
Pp125FAK is required for stretch dependent morphological response of endothelial cells.
Topics: Animals; Calcium; Calcium Channels; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Elasticity; Endothelium, Vascular; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oligonucleotides, Antisense; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rabbits; Retinoblastoma-Like Protein p130 | 1998 |
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Cell Adhesion Molecules; Chromones; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Identification of an amino-terminal substrate-binding domain in the Yersinia tyrosine phosphatase that is required for efficient recognition of focal adhesion targets.
Topics: Animals; Bacterial Outer Membrane Proteins; Binding Sites; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; Kinetics; Molecular Weight; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Rats; Recombinant Fusion Proteins; Retinoblastoma-Like Protein p130; Sequence Deletion; Substrate Specificity; Yersinia pseudotuberculosis | 1998 |
The counteradhesive protein SPARC regulates an endothelial paracellular pathway through protein tyrosine phosphorylation.
Topics: Albumins; Benzoquinones; beta Catenin; Biological Transport; Cells, Cultured; Cytoskeletal Proteins; Endothelium; Enzyme Inhibitors; Genistein; Immunoblotting; Intercellular Junctions; Lactams, Macrocyclic; Osteonectin; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Trans-Activators | 1998 |
Regulation of astrocyte morphology by RhoA and lysophosphatidic acid.
Topics: Actins; ADP Ribose Transferases; Animals; Astrocytes; Botulinum Toxins; Cell Adhesion; Cell Size; Cells, Cultured; Colforsin; Cyclic AMP; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; DNA; GTP-Binding Proteins; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Paxillin; Phosphoproteins; Phosphotyrosine; Prosencephalon; Rats; rhoA GTP-Binding Protein; Virulence Factors, Bordetella | 1998 |
Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxyl Radical; Hypoxanthine; Immunohistochemistry; Iron Chelating Agents; Microscopy, Fluorescence; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Reactive Oxygen Species; Retinoblastoma-Like Protein p130; Xanthine Oxidase | 1998 |
Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Dimethyl Sulfoxide; Estradiol; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Tyrosine | 1998 |
The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Fractionation; Cell Membrane; Cells, Cultured; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Cytosol; Fibroblasts; Humans; Mice; Molecular Weight; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; src Homology Domains; src-Family Kinases; T-Lymphocytes; Vanadates | 1999 |
Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.
Topics: Angiotensin II; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Enzyme Activation; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Mitogen-Activated Protein Kinase 1; Nuclear Proteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proteins; Repressor Proteins; Signal Transduction | 1999 |
Antiepileptic teratogen valproic acid (VPA) modulates organisation and dynamics of the actin cytoskeleton.
Topics: Actins; Actomyosin; Adenosine Triphosphate; Animals; Anticonvulsants; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Size; Cells, Cultured; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Gelsolin; Microscopy, Confocal; Microscopy, Fluorescence; Nocodazole; Octoxynol; Paxillin; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Teratogens; Time Factors; Trypsin; Tubulin; Valproic Acid; Vinculin | 1999 |
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.
Topics: Amino Acid Substitution; Catalysis; Catalytic Domain; Cell Adhesion Molecules; Cell Line, Transformed; Codon; Cytoskeletal Proteins; Endocytosis; Endothelial Growth Factors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Isoenzymes; Kidney; Lymphokines; Mutagenesis, Site-Directed; Neovascularization, Physiologic; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; src Homology Domains; Structure-Activity Relationship; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Glucocorticoid effect on human mesangial cell cytoskeletal proteins.
Topics: Cell Adhesion Molecules; Cell Line, Transformed; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Dexamethasone; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Glucocorticoids; Humans; Immunosorbent Techniques; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases | 1999 |
Complement-mediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions.
Topics: Actin Cytoskeleton; Actins; Animals; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Complement Membrane Attack Complex; Complement System Proteins; Cycloheximide; Cytoskeletal Proteins; Epithelial Cells; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerulonephritis; Immunoglobulin G; Integrin alpha3beta1; Integrins; Kidney Glomerulus; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, Laminin; Talin; Vanadates; Vinculin | 1999 |
Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase erk2 in fibroblasts.
Topics: 3T3 Cells; Animals; Antibodies; Cell Adhesion; Cell Adhesion Molecules; Cell Nucleus; Collagen; Crk-Associated Substrate Protein; Cytoskeletal Proteins; DNA; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Molecular Weight; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Solubility; Tumor Cells, Cultured | 1999 |
The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.
Topics: Actins; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Size; Crk-Associated Substrate Protein; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Membrane Potentials; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Receptor, IGF Type 1; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured | 1999 |
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Hypoxia; Cell Membrane; Cell Nucleus; Cells, Cultured; Cytoplasm; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Myocardium; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Rats; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1999 |
Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase.
Topics: Adaptor Proteins, Signal Transducing; Calcitonin; Calcium; Cell Adhesion Molecules; Cell Line; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Receptors, Calcitonin; Retinoblastoma-Like Protein p130; Signal Transduction | 1999 |
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Mutation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); src-Family Kinases; Transfection | 1999 |
Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation.
Topics: Anisomycin; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Membrane; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Recombinant Proteins; Signal Transduction; src Homology Domains; Transfection | 1999 |
RhoA inactivation enhances endothelial barrier function.
Topics: Actins; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; beta Catenin; Biological Transport; Botulinum Toxins; Cattle; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Fluorescent Antibody Technique; Hemostatics; Image Processing, Computer-Assisted; Intercellular Junctions; Myosins; Paxillin; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pulmonary Artery; rhoA GTP-Binding Protein; Stress, Mechanical; Thrombin; Trans-Activators; Tyrosine | 1999 |
Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.
Topics: Animals; Cell Adhesion; Cell Size; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Fibroblasts; Fibronectins; Isoenzymes; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Rats; Type C Phospholipases; Tyrosine | 1999 |
Tyrosine phosphorylation and subcellular localization of focal adhesion proteins during in vitro decidualization of human endometrial stromal cells.
Topics: Cell Adhesion Molecules; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Cytoskeleton; Decidua; Endometrium; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; src-Family Kinases; Stromal Cells; Subcellular Fractions | 1999 |
Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Norepinephrine; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Transfection; Tyrphostins | 1999 |
L-type Ca2+ channels and purinergic P2X2 cation channels participate in calcium-tyrosine kinase-mediated PC12 growth cone arrest.
Topics: Actins; Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Cytoskeletal Proteins; Kinetics; Nerve Growth Factors; Neurites; Nifedipine; omega-Conotoxins; Paxillin; PC12 Cells; Pheochromocytoma; Phosphoproteins; Phosphotyrosine; Potassium Chloride; Protein-Tyrosine Kinases; Pseudopodia; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X2 | 2000 |
Activation of m3 muscarinic receptors induces rapid tyrosine phosphorylation of p125(FAK), p130(cas), and paxillin in rat pancreatic acini.
Topics: ADP Ribose Transferases; Amylases; Animals; Botulinum Toxins; Calcium; Calcium Signaling; Carbachol; Cells, Cultured; Cholinergic Agonists; Colchicine; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Retinoblastoma-Like Protein p130; rho GTP-Binding Proteins | 2000 |
Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.
Topics: Amino Acid Substitution; Animals; Binding Sites; COS Cells; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; DNA-Binding Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; LIM Domain Proteins; Mutation; Osmolar Concentration; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Recombinant Fusion Proteins; src Homology Domains; src-Family Kinases; Transfection | 2000 |
Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells.
Topics: Antigens, CD; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hyaluronan Receptors; Hyaluronic Acid; Kinetics; Microcirculation; Mitogen-Activated Protein Kinases; Oligosaccharides; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Pulmonary Artery; Pulmonary Circulation; Signal Transduction; Umbilical Veins | 2000 |
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
Topics: Actins; Adult; Cell Adhesion; Cytoskeletal Proteins; DNA-Binding Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Human Growth Hormone; Humans; Janus Kinase 2; Neutrophils; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Echistatin inhibits pp125FAK autophosphorylation, paxillin phosphorylation and pp125FAK-paxillin interaction in fibronectin-adherent melanoma cells.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Signaling Peptides and Proteins; Kinetics; Melanoma, Experimental; Mice; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Vitronectin; Tumor Cells, Cultured | 2000 |
Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases.
Topics: Actins; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Line, Transformed; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Focal Adhesions; Lactams, Macrocyclic; Mice; Microscopy, Fluorescence; Microtubules; Nocodazole; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Quinones; Rifabutin; src-Family Kinases; Stress Fibers; Tyrosine; Vimentin | 2000 |
Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions.
Topics: Actins; Animals; beta Catenin; Cadherins; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Intercellular Junctions; Male; Microscopy, Immunoelectron; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Signal Transduction; Spermatogenesis; Spermatozoa; Trans-Activators; Vinculin | 2001 |
A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.
Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Division; Cell Size; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Oncogene Proteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-met; Retinoblastoma-Like Protein p130; Signal Transduction; Stress Fibers; Wound Healing | 2000 |
Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.
Topics: Adaptor Proteins, Signal Transducing; Bone Marrow Cells; Cell Adhesion Molecules; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Cytoskeletal Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Hematopoietic Stem Cells; Humans; Janus Kinase 2; Nuclear Proteins; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Signal Transduction; STAT2 Transcription Factor; STAT4 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrphostins | 2001 |
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Indoles; Maleimides; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin-Light-Chain Phosphatase; Nucleic Acid Synthesis Inhibitors; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Thiazoles; Thiazolidines; Time Factors | 2001 |
Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Cell Hypoxia; Crk-Associated Substrate Protein; Culture Techniques; Cytoskeletal Proteins; Cytoskeleton; Female; Focal Adhesion Protein-Tyrosine Kinases; Integrin beta1; Ketoglutaric Acids; Kidney Tubules, Proximal; Oxidative Phosphorylation; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Rabbits; Retinoblastoma-Like Protein p130 | 2001 |
Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Amides; Animals; Bombesin; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Pyridines; Retinoblastoma-Like Protein p130; rho-Associated Kinases; Stress Fibers | 2001 |
Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Cycle; Cell Division; Cell Movement; CHO Cells; Cricetinae; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; GRB2 Adaptor Protein; GRB7 Adaptor Protein; Mice; Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Subunits; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Transfection | 2001 |
Effect of H-7 on cultured human trabecular meshwork cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; beta Catenin; Cell Adhesion; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Time Factors; Trabecular Meshwork; Trans-Activators; Vinculin | 2001 |
Differential phosphorylation of paxillin in response to surface-bound serum proteins during early osteoblast adhesion.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Blood Proteins; Cell Adhesion; Cell Adhesion Molecules; Cell Membrane; Cytoskeletal Proteins; Fibronectins; Mice; Microscopy, Confocal; Osteoblasts; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polystyrenes; Serum Albumin; Vitronectin | 2001 |
Topographic changes of focal adhesion components and modulation of p125FAK activation in stretched human periodontal ligament fibroblasts.
Topics: Cells, Cultured; Cytoskeletal Proteins; Dental Stress Analysis; Enzyme Activation; Fibroblasts; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Immunoblotting; Integrin beta1; Paxillin; Periodontal Ligament; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Stress, Mechanical | 2001 |
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase.
Topics: Amino Acid Motifs; Animals; Binding Sites; Cell Adhesion; Cell Size; Clone Cells; Culture Media; Cytoskeletal Proteins; Embryo, Mammalian; Expressed Sequence Tags; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Targeting; Integrins; Laminin; Mice; Oligodeoxyribonucleotides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Stem Cells; Transfection | 2002 |
Human endothelial Pyk2 is expressed in two isoforms and associates with paxillin and p130Cas.
Topics: ADP-Ribosylation Factors; Cell Line; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Endothelium; Endothelium, Vascular; Focal Adhesion Kinase 2; GTPase-Activating Proteins; Histamine; Humans; Ligands; Paxillin; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Receptors, Thrombin; Retinoblastoma-Like Protein p130; RNA, Messenger; Thrombin | 2002 |
PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow.
Topics: Arsenicals; Blotting, Western; Cell Adhesion; Cell Size; Collagen; Colonic Neoplasms; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Oligonucleotides, Antisense; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; PTEN Phosphohydrolase; Rheology; Stress, Mechanical; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L).
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Cytoskeletal Proteins; Humans; Immunoglobulins; Integrins; Kinetics; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Mucoproteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured | 2002 |
Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1.
Topics: 3T3 Cells; Animals; Cadherins; Cell Communication; Cell Line; Cellular Apoptosis Susceptibility Protein; Culture Media, Serum-Free; Cytoskeletal Proteins; Enzyme Activation; Epithelial Cells; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Keratinocytes; L Cells; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; src-Family Kinases; Transfection; Transforming Growth Factor beta | 2002 |
A new type of antimetastatic peptide derived from fibronectin.
Topics: Animals; Cell Adhesion; Cytoskeletal Proteins; Endothelium, Vascular; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Integrin alpha4beta1; Liver Neoplasms, Experimental; Lymphoma, B-Cell; Mice; Paxillin; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Splenic Neoplasms; Vascular Cell Adhesion Molecule-1 | 2002 |
Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants.
Topics: Animals; Carcinoma, Lewis Lung; Cell Movement; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesions; Mice; Neoplasm Proteins; Okadaic Acid; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Phosphatase 2; Protein Processing, Post-Translational | 2002 |
Expression patterns of focal adhesion associated proteins in the developing retina.
Topics: Animals; Blotting, Western; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Focal Adhesions; Immunoblotting; Immunohistochemistry; Integrin beta1; Microscopy, Fluorescence; Neuroglia; Paxillin; Phosphoproteins; Phosphotyrosine; Retina; Xenopus; Xenopus Proteins | 2002 |
Protein phosphatase-2A restricts migration of Lewis lung carcinoma cells by modulating the phosphorylation of focal adhesion proteins.
Topics: Animals; Birds; Blotting, Western; Carcinoma, Lewis Lung; Cell Movement; Cytoskeletal Proteins; Down-Regulation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Genes, src; Humans; Mice; Mutation; Neoplasm Metastasis; Neoplasm Proteins; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Precipitin Tests; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein-Tyrosine Kinases | 2003 |
Isolation of novel substrates using a tyrosine kinase overlay/in situ assay.
Topics: Animals; Baculoviridae; Cell Line; Cloning, Molecular; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genetic Vectors; Immunoblotting; Insecta; Mice; Paxillin; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Substrate Specificity | 2003 |
Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk.
Topics: Animals; Animals, Newborn; Aorta, Thoracic; Cell Movement; Cells, Cultured; Crk-Associated Substrate Protein; Cyclic GMP; Cytoskeletal Proteins; Enzyme Activation; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Muscle, Smooth, Vascular; Mutagenesis; Nitric Oxide; Nitric Oxide Donors; Paxillin; Penicillamine; Phosphoproteins; Phosphotyrosine; Platelet Aggregation Inhibitors; Precipitin Tests; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; Rats, Sprague-Dawley; Retinoblastoma-Like Protein p130; Thionucleotides; Triazenes | 2003 |
Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Adhesion Molecules; Cell Membrane; CHO Cells; Cricetinae; Cytoskeletal Proteins; Humans; Integrin alpha4beta1; Jurkat Cells; Mutagenesis, Site-Directed; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Recombinant Proteins; T-Lymphocytes; Transfection | 2003 |
Smooth muscle cell migration stimulated by interleukin 6 is associated with cytoskeletal reorganization.
Topics: Actins; Animals; Aorta, Thoracic; Cell Movement; Cells, Cultured; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Interleukin-6; Male; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymers; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley | 2003 |
Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants.
Topics: Animals; Blotting, Western; Carcinoma, Lewis Lung; Cytoskeletal Proteins; Down-Regulation; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Okadaic Acid; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Precipitin Tests; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tumor Cells, Cultured | 2003 |
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.
Topics: Actinin; Actins; Actomyosin; Animals; Cell Adhesion Molecules; Cell Movement; Cloning, Molecular; Cytoskeletal Proteins; Endothelial Cells; Extracellular Matrix; Focal Adhesions; Glycoproteins; Integrin beta3; Microfilament Proteins; Microscopy, Fluorescence; Paxillin; Phosphoproteins; Phosphotyrosine; Pseudopodia; Talin; Tensins; Vinculin; Wound Healing; Zyxin | 2003 |
Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes.
Topics: Animals; Calcium; Cholecystokinin; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Activation; In Vitro Techniques; Macromolecular Substances; Male; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; Rats, Wistar; Retinoblastoma-Like Protein p130; Sincalide; Time Factors | 2003 |
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mutation; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; src-Family Kinases; Transfection; Tumor Cells, Cultured | 2004 |
Participation of p97Eps8 in Src-mediated transformation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Agar; Animals; Blotting, Northern; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chickens; Cortactin; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Histones; Hydroxamic Acids; Immunoblotting; Microfilament Proteins; Mutation; Paxillin; Phosphoproteins; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; Time Factors; Transfection | 2004 |
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Aorta; Cell Movement; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Glutathione Transferase; Humans; Immunoblotting; Microscopy, Fluorescence; Mutation; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; RNA, Small Interfering; Swine; Telomerase; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading.
Topics: Actin Cytoskeleton; Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Extracellular Matrix; Fibroblasts; Focal Adhesions; Humans; Integrin alphaVbeta3; Integrins; Male; Microscopy, Electron, Scanning; Microscopy, Video; Paxillin; Phosphoproteins; Phosphotyrosine; Rats; Stress Fibers; Stress, Mechanical; Thiazoles; Thiazolidines; Time Factors; Vinculin | 2004 |
Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes.
Topics: Actin Cytoskeleton; Actins; Asthma; Cell Adhesion; Cell Membrane Structures; Cytoskeletal Proteins; Disintegrins; Eosinophils; Fibroblasts; Gelsolin; Humans; Integrin alpha4beta1; Interleukin-5; Macrophages; Matrix Metalloproteinase 8; Osteoclasts; Paxillin; Phenanthrolines; Phosphoproteins; Phosphotyrosine; Rhinitis; Talin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vinculin | 2004 |
Measurement of protein tyrosine phosphorylation in cell adhesion.
Topics: 3T3 Cells; Animals; Cell Adhesion; Chick Embryo; Cytoskeletal Proteins; Extracellular Matrix; Immunohistochemistry; Mice; Microscopy, Fluorescence; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine | 2005 |
Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells.
Topics: Angiotensin II; Cell Movement; Cell Proliferation; Cells, Cultured; Cytoskeletal Proteins; Endothelial Cells; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Signal Transduction; Umbilical Veins | 2005 |
Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.
Topics: Actins; Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Collagen; Contact Inhibition; Cytoskeletal Proteins; Cytoskeleton; Fibronectins; Gene Silencing; Humans; Insulin-Like Growth Factor I; Integrin beta1; LIM Domain Proteins; Mice; Microfilament Proteins; Molecular Sequence Data; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Isoforms; Protein Structure, Tertiary; Sequence Alignment | 2005 |
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.
Topics: Animals; Carcinoma; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Collagen; Colon; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Liver; Liver Neoplasms; Male; Microcirculation; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Oligonucleotides; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Tyrosine | 2005 |
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
Topics: Animals; Blotting, Western; Cell Adhesion; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Humans; Immunoblotting; Immunoprecipitation; Mutation; Neoplasms; Paxillin; Peptides; Phenotype; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 3; src-Family Kinases; Thyroid Gland; Thyroid Neoplasms; Transfection; Tyrosine | 2005 |
Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Humans; Neoplasm Metastasis; Osteosarcoma; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Retinoblastoma-Like Protein p130; RNA Interference; src-Family Kinases | 2005 |
EGF receptor activity is essential for adhesion-induced stress fiber formation and cofilin phosphorylation.
Topics: Actin Cytoskeleton; Animals; Cell Adhesion; Cofilin 2; Culture Media, Serum-Free; ErbB Receptors; Integrins; Mice; NIH 3T3 Cells; Paxillin; Phosphorylation; Phosphotyrosine; rhoA GTP-Binding Protein; Serum Response Factor; Signal Transduction; Stress Fibers | 2005 |
Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase.
Topics: Amino Acid Motifs; Animals; Cell Line; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Gene Deletion; Gene Expression Regulation; Mice; Paxillin; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein Transport | 2006 |
Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space.
Topics: Adult; Detergents; Female; Fibronectins; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Male; Middle Aged; Neutrophils; Paxillin; Phosphotyrosine; Proto-Oncogene Proteins; src-Family Kinases; Tyrosine; Wounds and Injuries | 2006 |
Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.
Topics: Actins; Animals; Cell Movement; Chlorocebus aethiops; Collagen Type I; COS Cells; Down-Regulation; Extracellular Matrix Proteins; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Integrin alpha2; Membrane Proteins; Mutation; Paxillin; Phosphotyrosine; Serum; Signal Transduction | 2006 |
Halothane affects focal adhesion proteins in the A 549 cells.
Topics: Cell Adhesion; Collagen Type IV; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Halothane; Humans; Paxillin; Phosphotyrosine; Tumor Cells, Cultured; Vinculin | 2007 |
Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas.
Topics: Animals; Binding Sites; Crk-Associated Substrate Protein; Dogs; Enzyme Activation; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Expression; HeLa Cells; Humans; Mice; Mice, Knockout; Paxillin; Phagosomes; Phosphotyrosine; Protein Binding; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; Salmonella typhimurium | 2006 |
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.
Topics: Animals; Blood Platelets; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Proto-Oncogene Proteins c-fyn; src-Family Kinases | 2007 |
Semisynthesis of unnatural amino acid mutants of paxillin: protein probes for cell migration studies.
Topics: Amino Acid Substitution; Cell Movement; Mutation; Paxillin; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Binding; Protein Engineering; Protein Precursors; Recombinant Fusion Proteins | 2007 |
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.
Topics: Cell Line; Cell Movement; Enzyme Activation; Focal Adhesions; GTP-Binding Proteins; Humans; Neoplasm Proteins; Paxillin; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptors for Activated C Kinase; Receptors, Cell Surface | 2007 |
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
Topics: Anaplastic Lymphoma Kinase; Animals; Cattle; Cell Membrane Permeability; Cells, Cultured; Cytoskeleton; DNA-Binding Proteins; Endothelial Cells; Enzyme Activation; ErbB Receptors; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Mitogen-Activated Protein Kinase 1; Paxillin; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor Protein-Tyrosine Kinases; Transcriptional Activation; Transforming Growth Factor beta1; Vinculin | 2007 |
High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion.
Topics: Animals; Cell Adhesion; Cell Line; Cell Movement; Cell Separation; Crk-Associated Substrate Protein; Enzyme Activation; Fibroblast Growth Factor 7; Focal Adhesion Protein-Tyrosine Kinases; Genes, Dominant; Humans; Hyperoxia; Paxillin; Phosphorylation; Phosphotyrosine; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiration, Artificial; rhoA GTP-Binding Protein; Tidal Volume | 2007 |
The impact of delay in cryo-fixation on biomarkers of Src tyrosine kinase activity in human breast and bladder cancers.
Topics: Aged; Aged, 80 and over; Biomarkers; Biopsy; Breast Neoplasms; Female; Focal Adhesion Protein-Tyrosine Kinases; Freezing; Humans; Immunoassay; Male; Middle Aged; Paxillin; Phosphorylation; Phosphotyrosine; src-Family Kinases; Time Factors; Tissue Fixation; Urinary Bladder Neoplasms | 2008 |
Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization.
Topics: Animals; Calpain; Cell Communication; Cell Movement; Cell Transformation, Viral; Cricetinae; Enzyme Activation; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; HeLa Cells; Humans; Mice; Mutant Proteins; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Pseudopodia; Rous sarcoma virus; Vanadates | 2008 |
Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Humans; Immunoprecipitation; Mass Spectrometry; Melanoma; Molecular Sequence Data; Mutation; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Binding; Serum; Transfection | 2008 |
Tac-beta1 inhibits FAK activation and Src signaling.
Topics: Cell Adhesion; Cells, Cultured; Crk-Associated Substrate Protein; Enzyme Activation; Focal Adhesion Kinase 1; Humans; Paxillin; Phosphotyrosine; Protein Subunits; Receptors, Interleukin-2; Signal Transduction; src-Family Kinases | 2008 |
Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells.
Topics: Actins; Animals; Antigens, Differentiation; CD47 Antigen; Cell Communication; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Humans; Intercellular Junctions; Macrophages; Nonmuscle Myosin Type IIA; Paxillin; Phagocytosis; Phosphorylation; Phosphotyrosine; Point Mutation; Receptors, Immunologic; Sheep; Synapses | 2008 |
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Actins; Adipocytes; Animals; Carrier Proteins; Cell Membrane Structures; Cells, Cultured; Enzyme Activation; Fibroblasts; Humans; Immunoprecipitation; Insulin; Mice; Myosin Type I; Myosins; Paxillin; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Sirolimus; TOR Serine-Threonine Kinases | 2008 |
The receptor phosphatase HmLAR2 collaborates with focal adhesion proteins in filopodial tips to control growth cone morphology.
Topics: Animals; Catalysis; CHO Cells; Cricetinae; Cricetulus; Focal Adhesions; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Growth Cones; Leeches; Mutation; Paxillin; Phenotype; Phosphotyrosine; Protein Binding; Protein Transport; Protein Tyrosine Phosphatases; Pseudopodia; Recombinant Fusion Proteins; RNA Interference; Signal Transduction; Transgenes | 2008 |
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.
Topics: Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Epithelium, Corneal; Focal Adhesion Protein-Tyrosine Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Models, Biological; Mutant Proteins; Paxillin; Phosphorylation; Phosphoserine; Phosphotyrosine | 2008 |
Phosphorylation of p130Cas initiates Rac activation and membrane ruffling.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Movement; Crk-Associated Substrate Protein; Fibroblasts; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Mice; Paxillin; Phosphorylation; Phosphotyrosine; Pseudopodia; rac1 GTP-Binding Protein; src-Family Kinases | 2008 |
Effects of micrometric titanium particles on osteoblast attachment and cytoskeleton architecture.
Topics: Actins; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cytoskeleton; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Models, Biological; Osteoblasts; Particle Size; Paxillin; Phosphorylation; Phosphotyrosine; Protein Transport; Stress Fibers; Titanium; Tubulin | 2010 |
Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions.
Topics: Animals; Cell Adhesion; CHO Cells; Cricetinae; Cricetulus; Cytosol; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Phosphorylation; Phosphotyrosine; Protein Binding; Spectrum Analysis | 2011 |
Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection.
Topics: Actins; Focal Adhesions; Gene Knockdown Techniques; HeLa Cells; HIV Infections; HIV-1; Humans; Microtubules; Paxillin; Phosphorylation; Phosphotyrosine; RNA, Small Interfering; Talin; Vinculin; Virus Internalization | 2011 |
Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chemotaxis; Embryo, Nonmammalian; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Knockdown Techniques; Growth Cones; Mutation; Oligonucleotides, Antisense; Paxillin; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pseudopodia; Signal Transduction; src-Family Kinases; Xenopus laevis | 2011 |
Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells.
Topics: Animals; Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Chemokine CCL2; Enzyme Activation; Female; Gene Knockdown Techniques; Humans; Mice; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, CCR2; Urinary Bladder Neoplasms | 2012 |
Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Knockdown Techniques; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Melanoma; Membrane Proteins; Mice; Models, Biological; Paxillin; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 12; rhoA GTP-Binding Protein; src-Family Kinases; Up-Regulation | 2012 |
Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers.
Topics: Antibodies, Monoclonal, Humanized; Antigens, CD; Antigens, Neoplasm; Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Female; Humans; Isotope Labeling; Neoplasm Proteins; Paxillin; Phosphatidylinositol 3-Kinase; Phosphorylation; Phosphotyrosine; Proteomics; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Signal Transduction; Trastuzumab | 2013 |
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Base Sequence; Carcinoma, Lewis Lung; Cell Adhesion; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockdown Techniques; Integrin alpha5beta1; Matrix Metalloproteinase 9; Membrane Microdomains; Mice; Models, Biological; Molecular Sequence Data; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphotyrosine; Polypeptide N-acetylgalactosaminyltransferase; Protein Multimerization; Signal Transduction; Syndecan-1 | 2013 |
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
Topics: Actins; Actomyosin; Animals; Cell Line; Cell Separation; Cytoskeleton; Fibroblasts; Flow Cytometry; Focal Adhesion Protein-Tyrosine Kinases; Green Fluorescent Proteins; Homeostasis; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Microscopy, Fluorescence; Paxillin; Phosphotyrosine; Protein Structure, Tertiary; RNA Interference; Signal Transduction; Stochastic Processes; Stress Fibers; Zyxin | 2013 |
Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Membrane; Dynamin II; Epidermal Growth Factor; ErbB Receptors; Integrin beta1; Ligands; MAP Kinase Signaling System; Mice; NIH 3T3 Cells; Paxillin; Phosphatidylinositol 4,5-Diphosphate; Phosphorylation; Phosphotyrosine; Polymerization; Sirolimus | 2014 |
Tyrphostin AG556 increases the activity of large conductance Ca
Topics: Animals; Basilar Artery; Cell Separation; Epidermal Growth Factor; ErbB Receptors; Genistein; HEK293 Cells; Humans; Indoles; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Male; Myocytes, Smooth Muscle; Phosphorylation; Phosphotyrosine; Protein Subunits; Rats, Sprague-Dawley; Tyrphostins; Vanadates; Vasodilation | 2017 |
Distinct focal adhesion protein modules control different aspects of mechanotransduction.
Topics: Animals; Cell Movement; Extracellular Matrix; Fluorescence Recovery After Photobleaching; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Mechanotransduction, Cellular; Mice; Models, Biological; NIH 3T3 Cells; Paxillin; Phosphorylation; Phosphotyrosine; Protein Transport; Pseudopodia; Signal Transduction; src-Family Kinases; Vinculin | 2017 |
Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13-RhoA-ROCK signaling pathway.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Polarity; Disease Progression; Focal Adhesions; Gastrins; Golgi Apparatus; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasm Invasiveness; Organic Chemicals; Pancreatic Neoplasms; Paxillin; Phosphorylation; Phosphotyrosine; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Time Factors | 2018 |
Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.
Topics: Acetylcholine; Actin Cytoskeleton; Actins; Adult; Biocatalysis; Cell Cycle Proteins; Female; Histamine; Humans; Lung; Male; Middle Aged; Models, Biological; Multiprotein Complexes; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Paxillin; Phosphorylation; Phosphoserine; Phosphotyrosine; Polo-Like Kinase 1; Polymerization; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Serotonin; Wiskott-Aldrich Syndrome Protein, Neuronal | 2020 |