phosphotyrosine and imatinib mesylate

Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Death; Cell Division; Colony-Forming Units Assay; Cyclosporins; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Genes, MDR; Humans; Imatinib Mesylate; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Pyrimidines; Transfection; Tumor Cells, Cultured; Verapamil

Topics: Animals; Benzamides; Catalysis; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Ligands; Models, Biological; Models, Molecular; Mutation; Phosphorylation; Phosphotyrosine; Piperazines; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; src Homology Domains; Vero Cells

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Humans; Imatinib Mesylate; Indoles; Lung Neoplasms; Mice; Mice, Nude; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Stem Cell Factor; Sunitinib; Tumor Cells, Cultured

Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Humans; Imatinib Mesylate; Mice; Phosphorylation; Phosphotyrosine; Piperazines; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Pyrimidines; src Homology Domains; Two-Hybrid System Techniques; Tyrosine; Ubiquitin-Protein Ligases

Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Amino Acids; Apoptosis; Benzamides; Cell Cycle; Cell Division; DNA-Binding Proteins; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Imatinib Mesylate; Inhibitory Concentration 50; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Models, Molecular; Mutation; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Structure, Tertiary; Pyridones; Pyrimidines; STAT5 Transcription Factor; Trans-Activators

Topics: Animals; Antibodies, Monoclonal; Benzamides; Cells, Cultured; Epidermal Growth Factor; Fluorescent Dyes; Fusion Proteins, bcr-abl; HeLa Cells; Humans; Imatinib Mesylate; Mass Spectrometry; Phosphorylation; Phosphotyrosine; Piperazines; Protein Array Analysis; Protein-Tyrosine Kinases; Proteome; Pyrimidines; Signal Transduction

Topics: Animals; Benzamides; Biomarkers, Tumor; Bone Marrow Cells; Cell Line, Tumor; Cell Separation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Intracellular Signaling Peptides and Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Mice; Phosphorylation; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Pyrimidines

Topics: Apoptosis; B-Lymphocytes; Benzamides; Cell Cycle; Cell Line; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Enzymologic; Humans; Imatinib Mesylate; Mutation; Myeloproliferative Disorders; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine

Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Mutation; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Stem Cell Factor; Survival Rate; Time Factors

Topics: Autocrine Communication; Benzamides; Cell Survival; Enzyme Activation; Gene Expression Regulation, Neoplastic; Hodgkin Disease; Humans; Imatinib Mesylate; Immunohistochemistry; Paracrine Communication; Phosphotyrosine; Piperazines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured

Topics: Antigens, CD34; Antineoplastic Agents; Benzamides; Cell Proliferation; Cryopreservation; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Imatinib Mesylate; Immunomagnetic Separation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytes, Mononuclear; Phosphotyrosine; Pilot Projects; Piperazines; Pyrimidines; Remission Induction; Reproducibility of Results; Time Factors; Treatment Outcome

Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzamides; Cell Proliferation; Dasatinib; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Genetic Vectors; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Immunoblotting; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mutation; Phosphotyrosine; Piperazines; Point Mutation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-abl; Pyrimidines; src-Family Kinases; Stem Cells; Thiazoles; Time Factors

Topics: Benzamides; Biomarkers, Tumor; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; mRNA Cleavage and Polyadenylation Factors; Oncogene Proteins, Fusion; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Proteomics; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction

Topics: Amino Acid Sequence; Animals; Benzamides; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Forming Units Assay; Disease Models, Animal; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Myeloid Progenitor Cells; Phosphotransferases; Phosphotyrosine; Piperazines; Protein Structure, Tertiary; Pyrimidines; Signal Transduction; Substrate Specificity

Topics: Animals; Apoptosis; Benzamides; Cell Line; Drug Therapy, Combination; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia; Male; Mice; Models, Biological; Phosphotyrosine; Piperazines; Pyrimidines; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line; Drug Synergism; Drug Therapy, Combination; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia; Male; Mice; Models, Biological; Phosphotyrosine; Piperazines; Pyrimidines; Xenograft Model Antitumor Assays

Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Signaling System; Molecular Probes; Phosphotyrosine; Piperazines; Pyrimidines; ras Proteins; Triazoles

Topics: Benzamides; Bone Marrow; Cell Death; Cell Line, Tumor; Culture Media, Conditioned; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Pyrimidines; RNA, Small Interfering; STAT3 Transcription Factor; Thiazoles

Topics: Animals; Antibodies; Benzamides; Cysteine; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Indium Radioisotopes; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Radioimmunodetection; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Apoptosis; Benzamides; Caspase 3; Cell Line; Cell Survival; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Imatinib Mesylate; Insulin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Piperazines; Platelet-Derived Growth Factor; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats; Receptor, Insulin; Retinal Ganglion Cells; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction

Topics: Amino Acid Substitution; Antineoplastic Agents; Benzamides; Catalytic Domain; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Humans; Imatinib Mesylate; Indoles; Kinetics; Microchemistry; Models, Biological; Mutant Proteins; Peptide Mapping; Phosphorylation; Phosphotyrosine; Piperazines; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Recombinant Fusion Proteins; Sunitinib

Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Binding Sites; Blotting, Western; Cell Adhesion; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytoskeletal Proteins; Fibronectins; HEK293 Cells; Humans; Imatinib Mesylate; K562 Cells; Microfilament Proteins; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; src Homology Domains; Tandem Mass Spectrometry; Tyrosine

Topics: Acetylation; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Proteome; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Valproic Acid

Topics: Animals; Antineoplastic Agents; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Exosomes; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Human Umbilical Vein Endothelial Cells; Humans; Imatinib Mesylate; Interleukin-8; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Neovascularization, Pathologic; Orotic Acid; Phosphorylation; Phosphotyrosine; Piperazines; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA, Messenger; Triazoles; Xenograft Model Antitumor Assays

Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzamides; Blast Crisis; Cell Membrane; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Phosphotyrosine; Piperazines; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tyrosine

Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Nucleus; Cell Survival; Ceramides; Dogs; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Fusion Proteins, bcr-abl; Gene Knockdown Techniques; Golgi Apparatus; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microsomes; Peptide Fragments; Phosphorylation; Phosphotyrosine; Piperazines; Protein Processing, Post-Translational; Protein Transport; Proteome; Pyrimidines; RNA, Small Interfering; Serine C-Palmitoyltransferase; Transcription, Genetic

Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Benzamides; HEK293 Cells; Humans; Imatinib Mesylate; Mice; Mutation, Missense; NIH 3T3 Cells; Phosphorylation; Phosphotyrosine; Piperazines; Point Mutation; Polymorphism, Single Nucleotide; PPAR gamma; Proline; Protein Binding; Protein Interaction Mapping; Protein Isoforms; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Tertiary; Proto-Oncogene Proteins c-abl; Pyrimidines; Sequence Homology, Amino Acid; Species Specificity; Transcription, Genetic

Topics: Drug Design; Hydrogen Bonding; Imatinib Mesylate; Indoles; Molecular Docking Simulation; Molecular Targeted Therapy; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Kinase Inhibitors; src-Family Kinases; Structure-Activity Relationship

Topics: Adult; Animals; Biomarkers; Cell Movement; Cells, Cultured; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Gene Silencing; Glucose; Guanine Nucleotide Exchange Factors; Humans; Imatinib Mesylate; Kidney Tubules; Mice; NIH 3T3 Cells; Phenotype; Phosphotyrosine; Proteasome Inhibitors; Protein-Tyrosine Kinases; Proteolysis; Reactive Oxygen Species; rhoA GTP-Binding Protein; Stress Fibers; Transforming Growth Factor beta1; Ubiquitin

Topics: Anemia, Sickle Cell; Anion Exchange Protein 1, Erythrocyte; beta-Thalassemia; Cell Adhesion; Cell-Derived Microparticles; Drug Evaluation, Preclinical; Endothelium, Vascular; Erythrocyte Deformability; Erythrocyte Membrane; Erythrocytes, Abnormal; Hemoglobin, Sickle; Humans; Imatinib Mesylate; Oxidative Stress; Oxygen; Phosphorylation; Phosphotyrosine; Plasma; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Sickle Cell Trait