phosphotyrosine has been researched along with epidermal growth factor in 373 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (10.99) | 18.7374 |
| 1990's | 218 (58.45) | 18.2507 |
| 2000's | 89 (23.86) | 29.6817 |
| 2010's | 19 (5.09) | 24.3611 |
| 2020's | 6 (1.61) | 2.80 |
| Authors | Studies |
|---|---|
| Honda, Y; Iwaki, M; Kuriyama, S; Yoshimura, N | 1 |
| Maa, MC; Moyers, JS; Parsons, JT; Parsons, SJ; Vines, RR; Wilson, LK | 1 |
| Liu, J; Piotrowski, J; Slomiany, A; Slomiany, BL | 1 |
| Knapp, AM; Knüchel, R; Mansbridge, JN; Sutherland, RM | 1 |
| Bertuzzi, G; Chamak, B; Girault, JA; Greengard, P; Pang, DT; Tixier, H; Wang, JK | 1 |
| Portnoy, DA; Smith, GA | 1 |
| Anderson, NG | 1 |
| Davis, RJ; Latour, DA; Raden, DL; Stanley, K; Theroux, SJ | 1 |
| Lukas, TJ; Staros, JV; Woltjer, RL | 1 |
| Hunter, T; Krieg, J | 1 |
| Cohen, S; Donaldson, RW | 1 |
| Dy, RC; Earp, HS; Huckle, WR | 1 |
| Dunn, WA; Fischer, JE; Humphreys-Beher, MG; Nakagawa, Y; Purushotham, KR; Schneyer, CA; Wang, PL | 1 |
| Green, SH; Qui, MS | 1 |
| Decker, SJ; Ohmichi, M; Saltiel, AR | 1 |
| Bradshaw, RA; Raffioni, S | 2 |
| Bird, TA; Saklatvala, J | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Carpenter, G; Kim, H; Kim, JW; Nishibe, S; Rhee, SG; Wahl, MI | 1 |
| Brock, T; Kahn, CR; Karasik, A; Pepinsky, RB; Reddy, SS | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Akanuma, Y; Kasuga, M; Koshio, O; Takaku, F; Tashiro-Hashimoto, Y; Tobe, K | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Kudryavtseva, NV; Nikolsky, NN; Reshetnikova, GF; Sorokin, AB | 1 |
| Iwashita, S; Mitsui, K | 1 |
| Nesterov, A; Nikolsky, N; Reshetnikova, G; Vinogradova, N | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Jeffs, RA; Outlaw, HE; Rhee, SG | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Rhee, SG | 1 |
| Nesterov, AM; Nikol'skiĭ, NN; Reshetnikova, GF; Sorkin, AD; Vinogradova, NA | 1 |
| Carpenter, G; Hernández-Sotomayor, SM; Nishibe, S; Rhee, SG; Tonks, NK; Wahl, MI | 1 |
| Dy, RC; Earp, S; Herman, B; Huckle, WR; Prokop, CA | 1 |
| Parsons, SJ; Wilson, LK | 1 |
| Ascoli, M; Miller, ES | 1 |
| Hirai, M; Shimizu, N | 1 |
| Fitzgerald, DL; Payne, DM; Wasilenko, WJ; Weber, MJ | 1 |
| Ballou, LM; Luther, H; Thomas, G | 1 |
| Gansbacher, B; Gilboa, E; Hershberg, R; Oval, J; Schlessinger, J; Taetle, R | 1 |
| Contreras, ML; Fink, D; Guroff, G; Kim, HS; Kim, UH; Park, DJ; Rhee, SG | 1 |
| Fischer, R; Kashles, O; Schlessinger, J; Ullrich, A; Yarden, Y | 1 |
| Anderson, D; Ellis, C; Koch, CA; Moran, MF; Pawson, T | 1 |
| Chomsky, O; Dvir, A; Gazit, A; Gilon, C; Levitzki, A; Milner, Y | 1 |
| Abdel-Ghany, M; Koland, J; Racker, E; Revis-Gupta, S | 1 |
| Budnik, LT; Mukhopadhyay, AK | 1 |
| Beguinot, L; Helin, K; Magni, M; Meldolesi, J; Pandiella, A | 1 |
| Iizuka, Y; Iwashita, S; Nishiya, S; Takatori, T; Takayama, Y; Tsuruo, T; Yamazaki, A; Yamori, T | 1 |
| Frackelton, AR; Kannan, B; Mermelstein, F; Posner, M | 1 |
| Anderson, NG; Erickson, AK; Ray, LB; Sturgill, TW | 1 |
| Dey, SK; Paria, BC; Tsukamura, H | 1 |
| Campos-González, R; Glenney, JR | 1 |
| Chu, SH; Walker, WA | 1 |
| Kornilova, ES; Nesterov, AM; Nikol'skiĭ, NN; Vdovina, IB | 1 |
| Dilts, CA; Ethier, SP; Moorthy, R | 1 |
| Cohen, S; Sawyer, ST | 1 |
| Evans, RM; Gamou, S; Gill, GN; Lin, C; Rosenfeld, MG; Shimizu, N; Thompson, DM; Weber, W | 1 |
| Landreth, GE; Rieser, GD; Williams, LK | 1 |
| Damsky, C; Hwang, F; Phillips, PD; Ross, AH; Vance, P | 1 |
| Hollenberg, MD; Pallen, CJ; Valentine, KA; Wang, JH | 1 |
| Bremer, EG; Hakomori, S; Schlessinger, J | 1 |
| MacLeod, CL; Magun, BE; Mendelsohn, J; Sunada, H | 1 |
| Bass, G; Wedner, HJ | 1 |
| Kadowaki, T; Kasuga, M; Koyasu, S; Nishida, E; Sakai, H; Takaku, F; Tobe, K; Toyoshima, K; Yahara, I; Yamamoto, T | 1 |
| Izumi, T; Kadowaki, T; Kasuga, M; Koyasu, S; Nishida, E; Sakai, H; Takaku, F; Tobe, K; Yahara, I | 1 |
| David-Pfeuty, T; Guesdon, F | 1 |
| Ek, B; Ekman, P; Engström, L | 1 |
| Carpentier, JL; Kahn, RC; Orci, L; White, MF | 1 |
| Chen, WS; Gill, GN; Glenney, JR; Lazar, CS; Rosenfeld, MG; Walton, GM; Zokas, LM | 1 |
| Carpenter, G; Daniel, TO; Wahl, MI | 1 |
| Maher, PA | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Kahn, CR; Karasik, A | 1 |
| Antoniades, HN; Graves, DT | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Carpenter, G; Nishibe, S; Rhee, SG; Suh, PG; Wahl, MI | 1 |
| Decker, SJ; Harris, P | 1 |
| Felder, S; Levitzki, A; Lyall, R; Margolis, B; Mervic, M; Rhee, SG; Schlessinger, J; Ullrich, A; Zilberstein, A | 1 |
| Ackerman, P; Osheroff, N | 1 |
| Hammacher, A; Heldin, CH; Nistér, M | 1 |
| Aoyagi, T; Kato, N; Kobayashi, H; Miura, Y; Nemoto, O; Suya, H; Umeda, K | 1 |
| Cohen, S; Ushiro, H | 1 |
| Blomberg, J; Reynolds, FH; Stephenson, JR; Van de Ven, WJ | 1 |
| Cooper, JA; Hunter, T | 2 |
| Earp, HS; O'Keefe, EJ; Rubin, RA | 1 |
| Bornstein, P; Casnellie, JE; Gallis, B; Krebs, EG; Pike, LJ | 1 |
| Bowen-Pope, DF; Cooper, JA; Hunter, T; Raines, E; Ross, R | 1 |
| Bowen-Pope, DF; Krebs, EG; Pike, LJ; Ross, R | 1 |
| Erikson, E; Erikson, RL; Foulkes, JG; Gilmer, TM | 1 |
| Eisen, HN; Frackelton, AR; Ross, AH | 1 |
| Hapgood, J; Lax, I; Libermann, TA; Naor, Z; Schlessinger, J; Schreiber, AB; Yarden, Y | 1 |
| Cohen, S | 1 |
| Buss, JE; Chouvet, C; Gill, GN | 1 |
| Hunter, T | 1 |
| Decker, SJ | 1 |
| Bowtell, DD; Langdon, WY | 1 |
| Seedorf, K; Sherman, M; Ullrich, A | 1 |
| Díez, JA; Elvira, M; Villalobo, A | 1 |
| Aoto, M; Fukami, Y; Sato, A; Sato, K | 1 |
| Barbier, A; Chen, Z; Nield, HS; Patel, TB; Sun, H | 1 |
| Darnell, JE; Gilman, MZ; Harpur, AG; Sadowski, HB; Shuai, K; Wilks, AF; Ziemiecki, A | 1 |
| Nakano, H; Ohno, H; Saito, T | 1 |
| Alexander, P; Davies, DE; Holt, SJ; Inman, CB | 1 |
| Errasfa, M; Stern, A | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Ohmichi, M; Saltiel, AR; Sawada, T | 1 |
| Breitbart, H; Lax, Y; Rubinstein, S | 1 |
| Birge, RB; Fajardo, JE; Glassman, R; Hanafusa, H; Hempstead, BL; Kraemer, R; Mahadeo, D | 1 |
| Brautigan, DL; Chen, J; Parsons, S | 1 |
| Domin, J; Higgins, T; Rozengurt, E | 1 |
| Anderson, NG; Milligan, G | 1 |
| Cantley, LC; Carraway, KL; Gullick, WG; Prigent, SA; Soltoff, SP | 1 |
| Erlich, HP; Groner, JP; Heights, R; Kraemer, BA; Zamora, RL | 1 |
| Kido, Y; Kishi, K; Rokutan, K; Sakai, A; Shizuka, F; Teramoto, F | 1 |
| Izumi, H; Kohno, K; Kung, HF; Kuwano, M; Ono, M; Ushiro, S | 1 |
| Hefti, F; Isono, F; Knüsel, B; Widmer, HR | 1 |
| Bayna, EM; Cheresh, DA; Klemke, RL; Yebra, M | 1 |
| Kim, S; Li, W; Rockow, S; Xiong, W; Xu, J | 1 |
| Antoniotti, S; De Bortoli, M; Hynes, NE; Maggiora, P; Sapei, ML; Taverna, D | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Doppler, W; Garimorth, K; Philipp, S; Welte, T | 1 |
| da Silva, AM; Fries, DM; Monteiro, HP; Peranovich, TM; Stern, A | 1 |
| Ahmad, S; Hollenberg, MD; Laniyonu, A; Saifeddine, M | 1 |
| Bermudez, E; Everitt, J; Ferriola, PC; Mangum, J; Stewart, W; Walker, C | 1 |
| Doki, Y; Inoue, M; Iwazawa, T; Kadowaki, T; Matsui, S; Oka, H; Shimaya, K; Shiozaki, H; Takeichi, M; Tamura, S | 1 |
| Carpenter, G; McCollum, GW; Polk, DB | 1 |
| Beerli, RR; Graus-Porta, D; Hynes, NE | 1 |
| Alexander, W; Bohmer, RM; Danks, JA; Fowler, KJ; Hibbs, ML; Maglitto, R; Mann, GB; Nice, EC; Thumwood, C; Walker, F | 1 |
| Kelleher, D; Long, A; McDevitt, J; Murphy, A; Sheils, O | 1 |
| Hirota, K; Imai, T; Kurachi, H; Ogren, L; Talamantes, F; Yamaguchi, M | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Nohara, A; Ohmichi, M; Sakamoto, Y; Zhang, ZX | 1 |
| Eling, TE; Everhart, AL; Glasgow, WC | 1 |
| Chen, K; Cohen, S; Ruff-Jamison, S | 1 |
| Adachi, T; Nakamura, T; Nakashima, S; Nozawa, Y; Saji, S | 1 |
| Cybulsky, AV; Fine, RN; Goodyer, PR; Kaskel, FJ; Lin, JJ | 1 |
| Cuveele, JF; de Witte, PA; Merlevede, WJ; Vandenheede, JR | 1 |
| Bian, L; Cao, H; Lei, ZM; Rao, CV | 1 |
| Brady, MJ; Mastick, CC; Saltiel, AR | 1 |
| Pessin, JE; Yamauchi, K | 1 |
| Anderson, JM; Balda, MS; Van Itallie, CM | 1 |
| Muller, WJ; Muthuswamy, SK | 1 |
| Breton, M; Gavaret, JM; Pierre, M; Pomerance, M | 1 |
| Bos, JL; Burgering, BM; Coffer, PJ; Kruijer, W; Peppelenbosch, MP | 1 |
| Bradshaw, RA; Wu, YY | 1 |
| Okada, S; Pessin, JE; Yamauchi, K | 1 |
| Ikemoto, H; Kaba, K; Miyaji, K; Nakano, A; Tani, E | 1 |
| Decker, SJ; Mayer, BJ; Saltiel, AR; Zhu, G | 1 |
| Davis, RJ; Raden, DL; Selva, E | 1 |
| Hamburger, AW; Mishra, S | 3 |
| Bos, JL; Hordijk, PL; Medema, RH; Moolenaar, WH; van Corven, EJ | 1 |
| Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
| Bombien, E; Offermanns, S; Schultz, G | 2 |
| Gilman, MZ; Sadowski, HB | 1 |
| Crouch, MF; Hendry, IA | 1 |
| Chen, K; Cohen, S; McGlade, J; Pawson, T; Ruff-Jamison, S | 1 |
| Carter, V; Parsons, M; Valentine, M | 1 |
| Bennett, W; Gerwin, BI; Harris, CC; Hui, F; Lupu, R; Murakami, M; Noguchi, M | 1 |
| Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM | 1 |
| Ohmichi, M; Pang, L; Ribon, V; Saltiel, AR | 1 |
| Langgut, W | 1 |
| Kitamura, N; Komada, M | 1 |
| Baldassare, JJ; Elder, JT; Fisher, GJ; Henderson, PA; Reynolds, NJ; Talwar, HS; Voorhees, JJ | 1 |
| Fish, EN; Ghislain, J; Stevens, JK; Trogadis, J | 1 |
| Burns, DM; Kawase, T; Ogata, S; Orikasa, M | 1 |
| Fogleman, PB; Schmidt-Ullrich, RK; Valerie, K; Walters, J | 1 |
| Greenberg, ME; Rosen, LB | 1 |
| Clark, S; Larkins, R; McNeil, A | 1 |
| Dilts, CA; Ethier, SP; Langton, BC | 1 |
| Denning, MF; Dlugosz, AA; Magnuson, T; Threadgill, DW; Yuspa, SH | 1 |
| Cao, X; Goh, KC; Guy, GR; Lim, YP; Ong, SH; Siak, CB; Tan, YH | 1 |
| Schwenger, P; Skolnik, EY; Vilcek, J | 1 |
| Decker, SJ; Holt, KH; Koretzky, GA; Motto, DG; Okada, S; Pessin, JE; Saltiel, AR; Waters, SB; Yamauchi, K | 1 |
| Bai, F; Decker, SJ; Draznin, B; Gill, GN; Kobayashi, M; Langlois, WJ; Leitner, JW; Olefsky, JM; Rose, DW; Saltiel, A; Sasaoka, T | 1 |
| Bowser, JM; Cohen, ME; Donowitz, M; Khurana, S; Levine, SA; Nath, SK; Tse, CM | 1 |
| Ribon, V; Saltiel, AR | 1 |
| Bacus, SS; Ben-Baruch, N; Chen, X; Karunagaran, D; Lavi, S; Leitner, O; Levkowitz, G; Ratzkin, BJ; Tzahar, E; Yarden, Y | 1 |
| Claesson-Welsh, L; Hooshmand-Rad, R; Rankin, S; Rozengurt, E | 1 |
| Bu, R; Humphreys-Beher, MG; Jonsson, R; Kerr, M; Olofsson, J; Purushotham, KR; Tao, Z | 1 |
| Barrie, A; Benfenati, F; Chieregatti, E; Miloso, M; Valtorta, F | 1 |
| Barrett, T; Davis, RJ; Galcheva-Gargova, Z; Klier, FG; Konstantinov, KN; Wu, IH | 1 |
| Band, H; Band, V; Fukazawa, T; Miyake, S | 1 |
| Bossenmaier, B; Häring, H; Tippmer, S | 1 |
| Baylink, DJ; Hashimoto, H; Lau, KH; Thomas, AB | 1 |
| Giancotti, FG; Mainiero, F; Pepe, A; Ren, Y; Yeon, M | 1 |
| Cheng, LY; Mack, P; Wang, DF; Yang, EB | 2 |
| Buckley, S; Elenius, K; Kim, ED; Klagsbrun, M; Plowman, GD; Riese, DJ; Stern, DF | 1 |
| Aimoto, S; Hatanaka, H; Ikeuchi, T; Yamada, M | 2 |
| Daly, JM; Evoy, D; Li, XK; Lieberman, MD; Naama, H; Paty, P | 1 |
| Asaka, M; Nobuta, A; Tanaka, J; Watanabe, M | 1 |
| Bistrian, BR; Chow, JC; Ciccarone, A; Laviola, L; Ling, PR; Qu, Z; Smith, RJ | 1 |
| Jänne, OA; Palvimo, JJ; Reinikainen, P | 1 |
| Klippel, A; Martin, SS; Olefsky, JM; Rose, DW; Saltiel, AR; Williams, LT | 1 |
| Chew, CS; Nakamura, K; Parente, J; Zhou, CJ | 1 |
| Fletcher, K; Gardner, MJ; Pogson, CI; Strain, AJ | 1 |
| Jammes, H; Marechal, H; Mauduit, P; Rossignol, B | 1 |
| Fenoglio-Preiser, CM; Heffelfinger, SC; Lower, EE; Miller, MA | 1 |
| Cohen, BD; Fell, HP; Foy, L; Green, JM; Kiener, PA; Zhang, K | 1 |
| Pei, Z; Williamson, JR; Yang, L | 1 |
| Akhtar, RA; Zhang, Y | 1 |
| Lamaze, C; Schmid, SL; Vieira, AV | 1 |
| Bae, YS; Baines, IC; Chock, PB; Kang, SW; Rhee, SG; Seo, MS; Tekle, E | 1 |
| Akanuma, Y; Fukushima, Y; Kadowaki, H; Kadowaki, T; Katsumata, D; Takahashi, Y; Tobe, K; Yazaki, Y | 1 |
| Cavenee, WK; Gill, GN; Huang, CM; Huang, HS; Ji, XD; Klingbeil, CK; Lin, H; Nagane, M; Nishikawa, R; Wiley, HS | 1 |
| Burke, TR; Giorgetti-Peraldi, S; Ottinger, E; Shoelson, SE; Wolf, G; Ye, B | 1 |
| Dziubinski, ML; Ethier, SP; Jove, R; Sartor, CI; Yu, CL | 1 |
| Barford, D; Flint, AJ; Tiganis, T; Tonks, NK | 1 |
| Cybulsky, AV; McTavish, AJ | 1 |
| Charest, A; Kwan, M; Tremblay, ML; Wagner, J | 1 |
| DiGiovanni, J; Rosenberg, MP; Xian, W | 1 |
| Hamaguchi, M; Imaizumi, M; Murase, M; Nishimura, M; Takeuchi, S | 1 |
| Baserga, R; Morrione, A; Taylor, SJ; Valentinis, B | 1 |
| Carter, JE; Karnovsky, MJ; Ottlinger, ME; Pukac, LA | 1 |
| Abolafia, CM; Bedrin, MS; Thompson, JF | 1 |
| Fendrick, JL; Geary, SM; Konishi, I; O'Brien, TJ; Parmley, TH; Quirk, JG | 1 |
| Fujiwara, S; Gohda, J; Imoto, M; Nagatsu, T; Umezawa, K; Watanabe, T | 1 |
| Aoki, N; Daub, H; Maly, K; Tinhofer, I; Ullrich, A; Yamaguchi-Aoki, Y; Zwick, E | 1 |
| Bertics, PJ; Cha, D; Houtman, JC; Wiepz, GJ | 1 |
| Chen, CF; Liang, YC; Lin, JK; Lin-shiau, SY | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Balaban, N; Goldkorn, T; Matsukuma, K; Shannon, M | 1 |
| Guy, GR; Lim, YP; Low, BC; Ong, SH | 1 |
| Ciocca, V; Eszterhas, A; Hoffman, R; Krymskaya, VP; Panettieri, RA | 1 |
| Briski, KP; Hosick, HL; McIntyre, BS; Sylvester, PW | 1 |
| Bennett, AM; Ravichandran, KS; Tiganis, T; Tonks, NK | 1 |
| Carr, BI; Ni, R; Nishikawa, Y | 1 |
| Fukuchi, S; Hori, T; Ito, F; Murakami, N; Shibamoto, S; Takeuchi, K | 1 |
| Casalbore, P; Consales, A; Fernandez, E; Larocca, LM; Lauretti, L; Mercanti, D; Pallini, R; Tancredi, A | 1 |
| Lucocq, J; Xue, L | 1 |
| Rokutan, K; Saito, T; Torigoe, J; Yamada, M | 1 |
| Carey, DJ; Rahmatullah, M; Rothblum, K; Schroering, A; Stahl, RC; Urban, B | 1 |
| Burgess, AW; Gonez, LJ; Hibbs, ML; Walker, F; Zhang, HH | 1 |
| Mollerup, S; Rivedal, E; Sanner, T; Vikhamar, G | 1 |
| Arruda, JA; Cardoso, LR; Qiu, YY; Ruiz, OS | 1 |
| Horwitz, KB; Lange, CA; Richer, JK; Shen, T | 1 |
| Burgess, AW; Gonez, LJ; Hibbs, ML; Kato, A; Levitzki, A; Pouliot, N; Walker, F | 1 |
| Cheng, HL; Feldman, EL; Kim, B; Margolis, B | 1 |
| Kwon, KS; Rhee, SG; Wu, Y | 1 |
| Theunissen, HJ; van den Doelen, AA; Veeneman, GH; Vink, PM; Zaman, GJ | 1 |
| Jope, RS; Zhang, L | 1 |
| Opresko, LK; Wiley, HS; Worthylake, R | 1 |
| Haugh, JM; Lauffenburger, DA; Schooler, K; Wells, A; Wiley, HS | 1 |
| Farrell, GC; Zhang, BH | 1 |
| de la Pena, JM; Mosher, DF; Sakai, T | 1 |
| Frankhuizen, WS; Maassen, JA; Smeets, RL; Telting, D; van der Zon, GC; Willems, PH | 1 |
| Anderson, RG; Liu, P | 1 |
| Mercurio, AM; Rabinovitz, I; Toker, A | 1 |
| Fischbach, GD; Ford, BD; Loeb, JA | 1 |
| Carlin, CR; Friend, LA; Hobert, ME | 1 |
| Betti, M; Canesi, L; Ciacci, C; Gallo, G; Gazzanelli, G; Malatesta, M | 1 |
| Cole, JA | 1 |
| Inobe, M; Katsube, Ki; Miyagoe, Y; Nabeshima, Yi; Takeda, S | 1 |
| Bertics, PJ; Frank, SJ; Houtman, JC; Jiang, J; Kim, SO; Ruppert, JM | 1 |
| Hashimoto, Y; Katayama, H; Kiyokawa, E; Kurata, T; Machinami, R; Matsuda, M; Mochizuki, N; Nakaya, M; Sakamoto, A | 1 |
| Akamatsu, T; Kasuga, M; Mizoguchi, A; Noguchi, H; Sakamoto, C; Uchida, T; Wada, K; Yonezawa, M | 1 |
| Alric, C; Bascands, JL; Girolami, JP; Pecher, C; Schanstra, JP | 1 |
| Ireland, ME; Mrock, LK | 1 |
| Keegan, BP; Sheflin, LG; Spaulding, SW | 1 |
| Brüning, JC; Burks, DJ; Kahn, CR; Winnay, JN | 1 |
| Faraggiana, T; Gresik, EW; Ka, A; Kashimata, M; Onetti-Muda, A; Sakagami, H; Sayeed, S | 1 |
| Arcaro, A; Domin, J; Ullrich, A; Wallasch, C; Waterfield, MD; Zvelebil, MJ | 1 |
| Chung, J; Kim, D; Kim, J | 1 |
| Liu, J; Ma, Y; Spence, MJ; Streiff, R; Vestal, RE | 1 |
| Bonjour, JP; Caverzasio, J; Palmer, G; Suzuki, A | 1 |
| Blagoev, B; Fernandez, MM; Lodish, HF; Mann, M; Nielsen, MM; Pandey, A; Roche, S; Steen, H | 1 |
| Fan, PD; Goff, SP | 1 |
| Clague, MJ; Kitamura, N; Mills, IG; Stenmark, H; Urbé, S | 1 |
| Cochran, BH; Fanburg, BL; Guan, KL; Simon, AR; Stewart, S; Vikis, HG | 1 |
| Hayashi, N; Higashiyama, S; Ihara, H; Kawata, S; Kitada, T; Matsuura, N; Matsuzawa, Y; Miyoshi, E; Noda, K; Taniguchi, N | 1 |
| Berg, AH; Engelman, JA; Lewis, RY; Lisanti, MP; Scherer, PE | 1 |
| Alvarez-Dominguez, C; Barbieri, MA; Gumusboga, A; Highfield, H; Roberts, RL; Stahl, PD; Wells, A | 1 |
| Cabrera, J; Díaz, R; Estévez, F; Fanjul, LF; Gallardo, G; López-Blanco, F; Quintana, J; Ruiz de Galarreta, CM; Santana, P; Tabraue, C | 1 |
| Ohlsson, B; Rehfeld, JF; Sundler, F | 1 |
| Bastiaens, PI; Reynolds, AR; Verveer, PJ; Wouters, FS | 1 |
| de Oliveira, LC; Gruia-Gray, J; Monteiro, HP; Peranovich, TM; Stern, A | 1 |
| Fernandez, M; Küster, B; Mann, M; Pandey, A; Steen, H | 1 |
| Cunnick, JM; Doupnik, CA; Mei, L; Wu, J | 1 |
| Emons, G; Gründker, C; Völker, P | 1 |
| Calvo, B; Caskey, L; Earp, HS; Ethier, S; Guttridge, K; Harrelson, J; Hynes, N; Kawata, E; Kozlowska, E; Sartor, CI; Zhou, H | 1 |
| Carpenter, G; Zhou, W | 1 |
| Backer, JM; Collinson, LM; Futter, CE; Hopkins, CR | 1 |
| Gorlatova, N; Kuznetsov, S; Lawrence, DA; Loukinov, D; Loukinova, E; Migliorini, MM; Mikhailenko, I; Ranganathan, S; Strickland, DK; Ulery, PG | 1 |
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| Ang, BK; Chen, Y; Choong, LY; Druker, BJ; Hew, CL; Li, B; Lim, S; Lim, YP; Lin, Q; Low, TY; Ray, RS; Sze, NS; Tan, YL; Toy, W; Wong, CH | 1 |
| Lidke, DS; Oliver, JM; Raymond-Stintz, MA; Steinberg, SL; Williams, L; Wilson, BS; Yang, S; Ying, W; Zhang, J | 1 |
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| Fu, L; Liu, J; Liu, Y; Sun, P; Wang, X; Yan, J; Yan, Q; Yu, L; Zhang, Z | 1 |
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| Camp, DG; Ding, SJ; Heibeck, TH; Monroe, ME; Opresko, LK; Qian, WJ; Schepmoes, AA; Smith, RD; Tolmachev, AV; Wiley, HS; Yang, F; Zhao, R | 1 |
| Dang, D; Dent, P; Fang, X; Greenbaum, S; Lee, Z; Mukherjee, A; Oyesanya, RA; Wu, J | 1 |
| Chang, JS; Chung, SH; Kim, JK; Kim, SK; Suh, PG; Yang, YR | 1 |
| Beynon, RJ; Blagoev, B; Clague, MJ; Hammond, DE; Hyde, R; Kratchmarova, I | 1 |
| Abella, JV; Blagoev, B; Feldhammer, M; Nossov, M; Park, M; Sangwan, V; Stuible, M; Tremblay, ML | 1 |
| Gutierrez, JA; Johnson, H; Lescarbeau, RS; White, FM | 1 |
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| Huang, X; Li, Y; Ma, K; Zhang, J | 1 |
| Chen, Y; Jiang, L; Lan, T; Li, Y; Qian, H; Wang, Y; Wu, M | 1 |
| Baird, B; Bryant, KL; Hammes, SR; Holowka, D; Singhai, A; Wakefield, DL | 1 |
| Besik, V; Breit, A; Glas, E; Gudermann, T; Muehlich, S; Solinski, HJ; Yarwood, SJ | 1 |
| Chae, YC; Kim, D; Kim, JH; Kim, KL; Kim, SJ; Lee, JB; Lee, S; Noh, JE; Ryu, SH | 1 |
| Cao, R; Li, X; Liang, J; Lu, Z; Wang, L; Xia, Y; Yang, W; Zhang, Y; Zheng, Y | 1 |
| Chen, L; Chen, Q; Feng, D; Gao, R; Liu, Q; Luo, Q; Ma, K; Mu, C; Zhou, C; Zhu, Y | 1 |
| Dong, M; Li, Y; Wang, Y; Ye, M; Zou, H | 1 |
| Deng, XL; Li, GR; Liu, YG; She, G; Song, Z; Sun, HY; Wang, Y; Xiao, GS | 1 |
| Fischer, W; Swarts, S; van der Geer, P; van der Meulen, T | 1 |
| Jones, N; Lau, HR; Wills, MKB | 1 |
| Goel, RK; Lukong, KE; Napper, S; Paczkowska, M; Reimand, J | 1 |
| Cha, M; Eichel, K; Gartner, ZJ; Jura, N; Liang, SI; Patterson, DM; van Lengerich, B; von Zastrow, M; Yoon, TY | 1 |
| Agazie, YM; Geldenhuys, WJ; Hartman, Z | 1 |
| Anrather, D; Ellmeier, W; Frohner, IE; Hartl, M; Mudrak, I; Ogris, E; Preglej, T; Schüchner, S; Sontag, E; Sontag, JM; Wadzinski, BE | 1 |
| Cai, Z; Chen, W; Chu, B; Huang, P; Ji, S; Ke, M; Kong, Q; Li, P; Tian, R; Zheng, Z | 1 |
| Belle, L; Daly, RJ; Gehling, F; Goodall, GJ; Khew-Goodall, Y; Li, X; Lonic, A; Nguyen, EV; Parton, RG; Schieber, NL | 1 |
| Acker, MG; Blacklow, SC; Cao, R; Chylek, LA; Erickson, A; Gabriel, KH; Gygi, SP; LaMarche, MJ; LaRochelle, J; Mohseni, M; Pfeiffer, A; Sorger, PK; Stegmaier, K; Subramanian, K; Vemulapalli, V | 1 |
| Feng, Y; Jin, X; Liu, J; Peng, P; Qu, Y; Shu, H; Wang, L; Wang, Y; Wei, M; Xia, M | 1 |
1 review(s) available for phosphotyrosine and epidermal growth factor
| Article | Year |
|---|---|
Direct on-membrane peptide mass fingerprinting with MALDI-MS of tyrosine-phosphorylated proteins detected by immunostaining.
Topics: Antibodies, Phospho-Specific; Blotting, Western; Carcinoma, Squamous Cell; Cell Extracts; Cell Line, Tumor; Cell Membrane; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphotyrosine; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2007 |
372 other study(ies) available for phosphotyrosine and epidermal growth factor
| Article | Year |
|---|---|
Growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial cells.
Topics: Adenosine Triphosphate; Autoradiography; Cells, Cultured; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Eye Proteins; Fetus; Fibroblast Growth Factor 2; Humans; Membrane Proteins; Phosphorylation; Phosphotyrosine; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Signal Transduction; Tyrosine | 1992 |
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.
Topics: Animals; Cell Line; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Fluorescent Antibody Technique; Genes, src; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Transfection; Tyrosine | 1992 |
Inhibition of EGF-induced gastric mucosal calcium channel phosphorylation by ebrotidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Ulcer Agents; Benzenesulfonates; Calcium Channels; Calcium Radioisotopes; Epidermal Growth Factor; Gastric Mucosa; Isradipine; Phosphorylation; Phosphotyrosine; Rats; Thiazoles; Tyrosine | 1992 |
Importance of tyrosine phosphatases in the effects of cell-cell contact and microenvironments on EGF-stimulated tyrosine phosphorylation.
Topics: Blotting, Western; Cell Communication; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1992 |
Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin.
Topics: Animals; Astrocytes; Brain; Cell Aggregation; Cerebral Cortex; Embryo, Mammalian; Epidermal Growth Factor; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred Strains; Neurons; Phosphorylation; Phosphotyrosine; Tyrosine | 1992 |
Cell biology. Devious devices of Salmonella.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; Microscopy, Electron; Microvilli; Phosphotyrosine; Salmonella typhimurium; Signal Transduction; Tyrosine | 1992 |
Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Growth Hormone; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tyrosine | 1992 |
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; Substrate Specificity; Thymidine; Transfection; Tyrosine | 1992 |
Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chromatography, Affinity; Cross-Linking Reagents; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Tyrosine | 1992 |
Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
Topics: Amino Acid Sequence; Base Sequence; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Sequence Alignment; Tumor Cells, Cultured; Tyrosine | 1992 |
Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: association of a M(r) 55,000 substrate with the receptor.
Topics: Animals; Animals, Newborn; Epidermal Growth Factor; ErbB Receptors; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Signal Transduction; Tissue Distribution; Tyrosine | 1992 |
Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Liver; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Tyrosine | 1992 |
Alterations in the subcellular distribution of p21ras-GTPase activating protein in proliferating rat acinar cells.
Topics: Animals; Cell Division; Cell Fractionation; Cell Membrane; Centrifugation, Density Gradient; Epidermal Growth Factor; Female; Golgi Apparatus; GTPase-Activating Proteins; Immunosorbent Techniques; Intracellular Membranes; Isoproterenol; Kinetics; Nuclear Envelope; Parotid Gland; Phosphorylation; Phosphotyrosine; Proteins; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Epidermal Growth Factor; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Immunoblotting; Isoenzymes; Kinetics; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine | 1992 |
Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.
Topics: 3T3 Cells; Animals; Enzyme Activation; Epidermal Growth Factor; Genes, src; Immunoblotting; Insulin; Kinetics; Macromolecular Substances; Mice; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, trkA; Tyrosine | 1992 |
Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
Topics: Animals; Cell Division; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Kinetics; Liver; Mitogens; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Rats; Thymidine; Tyrosine | 1992 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Epidermal Growth Factor; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphotyrosine; Sequence Homology, Nucleic Acid; Type C Phospholipases; Tyrosine | 1990 |
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Topics: Annexins; Calcium; Calcium-Binding Proteins; Carcinoma, Squamous Cell; Cell Division; Cytoplasm; Drug Tolerance; Epidermal Growth Factor; ErbB Receptors; Humans; Mutation; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Liver; Phosphorylation; Phosphotyrosine; Portal Vein; Proteins; Rats; Receptor, Insulin; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Epidermal growth factor induces tyrosine phosphorylation of epidermal growth factor receptors not occupied with ligand in intact A431 cells.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Ligands; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Examination of the role of serine phosphorylation in phospholipase C-gamma and its related P47 in cAMP-mediated depression of epidermal growth factor signal transduction.
Topics: Colforsin; Cross Reactions; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1990 |
Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells.
Topics: Biological Transport; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis.
Topics: Animals; Cell Line; Enzyme Activation; Epidermal Growth Factor; Epithelium; Hydrolysis; Immunoblotting; Immunosorbent Techniques; Isoenzymes; Liver; Mice; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tyrosine | 1990 |
[The immunofluorescent detection of phosphorylated receptors of the epidermal growth factor during their internalization in A-431 cells].
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Phosphorylation; Phosphotyrosine; Staining and Labeling; Temperature; Tumor Cells, Cultured; Tyrosine | 1990 |
Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.
Topics: Catalysis; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Immunosorbent Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1990 |
Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcimycin; Calcium; Cell Line; Epidermal Growth Factor; Ionomycin; Kinetics; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Terpenes; Thapsigargin; Tyrosine | 1990 |
Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src.
Topics: Animals; Cell Line; DNA Replication; Epidermal Growth Factor; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Mice; Mutation; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1990 |
Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Immune Sera; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Tyrosine | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1991 |
MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways.
Topics: Adipose Tissue; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Reactivators; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Xenopus | 1991 |
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Topics: Animals; Blotting, Southern; Burkitt Lymphoma; Cell Division; DNA, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genetic Vectors; Humans; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1991 |
Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; In Vitro Techniques; Isoenzymes; Nerve Growth Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Type C Phospholipases; Tyrosine | 1991 |
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Topics: Animals; Cell Line; DNA; DNA Mutational Analysis; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, Suppressor; Ligands; Macromolecular Substances; Mice; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor Aggregation; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1991 |
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Topics: Amino Acid Sequence; Binding Sites; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Sorting Signals; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sequence Homology, Nucleic Acid; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.
Topics: Animals; Catechols; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; In Vitro Techniques; Keratinocytes; Molecular Weight; Nitriles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins | 1991 |
Heparin stimulates epidermal growth factor receptor-mediated phosphorylation of tyrosine and threonine residues.
Topics: Amino Acids; Animals; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Glutathione Transferase; Heparin; Humans; Insecta; Manganese; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Threonine; Tyrosine | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Chromosome Deletion; Epidermal Growth Factor; ErbB Receptors; Kinetics; Membrane Potentials; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 1991 |
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Molecular Weight; Neoplasm Metastasis; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Somatomedin; Sepharose; Tyrosine | 1991 |
Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Female; Haptens; Humans; Indicators and Reagents; Mice; Mice, Inbred BALB C; Molecular Weight; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Tyrosine | 1991 |
Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Autoradiography; Buffers; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Indicators and Reagents; Kinetics; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
Epidermal growth factor-specific protein tyrosine phosphorylation in preimplantation embryo development.
Topics: Animals; Blastocyst; Catechols; Embryonic Development; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Nitriles; Phosphorylation; Phosphotyrosine; Pregnancy; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Tyrphostins | 1991 |
Immunodetection of the ligand-activated receptor for epidermal growth factor.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fluorescent Antibody Technique; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Growth factor signal transduction in human intestinal cells.
Topics: Carcinoma; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Kinetics; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
[The direct demonstration of the tyrosine phosphorylation of epidermal growth factor receptors internalized in the endosomes of A431 cells].
Topics: Antibodies; Carcinoma, Squamous Cell; Cell Fractionation; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Organelles; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1991 |
Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells.
Topics: Animals; Carcinoma; Culture Media; Epidermal Growth Factor; ErbB Receptors; Female; Growth Substances; Mammary Neoplasms, Experimental; Neoplasm Proteins; Phenotype; Phosphoproteins; Phosphotyrosine; Rats; Tyrosine | 1991 |
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.
Topics: Animals; Autoradiography; Calcium; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Time Factors; Tyrosine | 1985 |
Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Chromosomes, Human, 6-12 and X; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Humans; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Receptors, Cell Surface; RNA, Messenger; RNA, Neoplasm; Translocation, Genetic; Tyrosine | 1985 |
Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Line; Cytoskeleton; Epidermal Growth Factor; ErbB Receptors; Humans; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cell Surface; Tyrosine | 1985 |
Inhibition of epidermal growth factor-induced phosphorylation by trifluoperazine.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Chlorpromazine; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Imipramine; Mice; Microscopy, Electron, Scanning; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Sulfonamides; Trifluoperazine; Tyrosine | 1985 |
Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone.
Topics: Brain; Calmodulin-Binding Proteins; Cations, Monovalent; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptors, Cell Surface; Tyrosine | 1985 |
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: Amino Acids; Animals; Carcinoma, Squamous Cell; Cattle; Cell Division; Cell Line; Depression, Chemical; Dogs; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Humans; Immunosorbent Techniques; Mice; Mouth Neoplasms; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene.
Topics: Epidermal Growth Factor; Glycoproteins; Humans; KB Cells; Molecular Weight; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogenes; Tyrosine | 1987 |
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor I; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Receptors, Somatomedin; Somatomedins; Tyrosine | 1987 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
The quantity of protein-bound [32P]phosphotyrosine in hepatocytes and fibroblasts. The effects of tyrosine protein kinase activating agents.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Liver; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells.
Topics: Amino Acids; Antibodies; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Kinetics; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Trypsin; Tyrosine | 1987 |
Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Ligands; Macromolecular Substances; Microinjections; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1988 |
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
Topics: Antibodies; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Cytosol; Epidermal Growth Factor; Hydrolysis; Inositol Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1988 |
Nerve growth factor induces protein-tyrosine phosphorylation.
Topics: Adrenal Gland Neoplasms; Animals; Bucladesine; Cell Line; Epidermal Growth Factor; Immunosorbent Techniques; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tyrosine | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Topics: Animals; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fasting; Insulin; Liver; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1988 |
Characterization of a high-molecular-weight protein immunoprecipitated by platelet-derived growth factor antisera.
Topics: Cell Line; Cross Reactions; Epidermal Growth Factor; Humans; Immune Sera; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1988 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Bradykinin; Calcium; Cell Line; Epidermal Growth Factor; ErbB Receptors; Immunoassay; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Type C Phospholipases; Tyrosine | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Topics: Antineoplastic Agents; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Tyrphostins | 1989 |
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Calcium; Casein Kinases; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphotyrosine; Protein Kinase C; Protein Kinases; Temperature; Tumor Cells, Cultured; Tyrosine | 1989 |
The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; Humans; In Vitro Techniques; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Time Factors; Tyrosine | 1989 |
Epidermal growth factor stimulates tyrosine phosphorylation of pig epidermal fibrous keratin.
Topics: Animals; Autoradiography; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epidermis; Immunologic Techniques; Keratins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Swine; Tyrosine | 1985 |
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Chromatography, Thin Layer; Electrophoresis, Paper; Enzyme Activation; Epidermal Growth Factor; Humans; Membrane Proteins; Peptides; Phosphotyrosine; Protein Kinases; Tyrosine | 1980 |
Differences in mechanisms of transformation by independent feline sarcoma virus isolates.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Mink; Phosphotyrosine; Protein Kinases; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1981 |
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1981 |
Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.
Topics: Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Receptors, Cell Surface; Tyrosine | 1981 |
Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.
Topics: Animals; Cell Division; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Regeneration; Male; Microsomes, Liver; Phosphoproteins; Phosphotyrosine; Protein Kinases; Rats; Receptors, Cell Surface; Tyrosine | 1982 |
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1982 |
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins.
Topics: Amino Acids; Animals; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Kinetics; Mice; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proteins; Tyrosine | 1982 |
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.
Topics: Animals; Cell Membrane; Epidermal Growth Factor; Growth Substances; Manganese; Membrane Proteins; Mice; Molecular Weight; Peptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Tyrosine | 1983 |
Avian sarcoma viruses, protein kinases and cell transformation.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Epidermal Growth Factor; Escherichia coli; Gene Expression Regulation; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1983 |
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; Humans; Mice; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine | 1983 |
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Immunoglobulin M; Phosphotyrosine; Pituitary Gland; Prolactin; Rats; Receptors, Cell Surface; Tyrosine | 1983 |
Purification of the receptor for epidermal growth factor from A-431 cells: its function as a tyrosyl kinase.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Receptors, Cell Surface; Tyrosine | 1983 |
Comparison of protein phosphorylations in variant A431 cells with different growth responses to epidermal growth factor.
Topics: Cell Line; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Receptors, Cell Surface; Tyrosine | 1984 |
The proteins of oncogenes.
Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Humans; Macromolecular Substances; Mice; Mitogen-Activated Protein Kinase 1; Oncogene Protein v-cbl; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Ubiquitin-Protein Ligases | 1995 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Phosphorylation of connexin-32 by the epidermal growth factor receptor tyrosine kinase.
Topics: Animals; Calcium; Cell Communication; Chelating Agents; Connexins; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Gap Junction beta-1 Protein; Gap Junctions; Liver; Phosphorylation; Phosphotyrosine; Rats | 1995 |
c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyanogen Bromide; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Trypsin; Tyrosine | 1995 |
Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulation.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Blotting, Western; Cell Line; Cyclic AMP; Dogs; Epidermal Growth Factor; ErbB Receptors; Gene Expression; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Isoenzymes; Kidney; Kinetics; Myocardium; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Recombinant Proteins; Transfection | 1995 |
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins.
Topics: Amino Acid Sequence; B-Lymphocytes; Base Sequence; Binding Sites; Cell Line; Epidermal Growth Factor; Glutathione Transferase; Humans; Interferon-alpha; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1993 |
Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line.
Topics: Animals; Becaplermin; Cell Line; Enzyme Activation; Epidermal Growth Factor; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Kinetics; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Receptors, Antigen, T-Cell; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus.
Topics: Amino Acid Sequence; Cell Fractionation; Cell Nucleus; Epidermal Growth Factor; Epitopes; ErbB Receptors; Humans; Microscopy, Immunoelectron; Molecular Sequence Data; Nuclear Proteins; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1994 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin; Membrane Proteins; Molecular Weight; Nerve Growth Factors; Neurons; Oncogene Protein v-crk; Paxillin; PC12 Cells; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, Nerve Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1994 |
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; Culture Media; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Tyrosine | 1994 |
Preferential inhibition of platelet-derived growth factor-stimulated DNA synthesis and protein tyrosine phosphorylation by nordihydroguaiaretic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cell Line; Cell Nucleus; Cells, Cultured; Dinoprostone; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Masoprocol; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Skin; Thymidine; Tyrosine | 1994 |
Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors.
Topics: Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; In Vitro Techniques; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tyrosine | 1994 |
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Baculoviridae; Binding Sites; Breast; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Moths; Oligopeptides; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-3; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Presence of growth factors in palmar and plantar fibromatoses.
Topics: Adult; Epidermal Growth Factor; Female; Fibroma; Fibronectins; Foot Dermatoses; Growth Substances; Hand Dermatoses; Humans; Immunohistochemistry; Male; Middle Aged; Phosphotyrosine; Procollagen; Transforming Growth Factor beta; Tyrosine | 1994 |
Epidermal growth factor-induced mitogen signals in cultured intestinal epithelial cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Epithelium; Jejunum; Mitogens; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Rats; Tyrosine | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Enzyme Activation; Epidermal Growth Factor; Growth Inhibitors; Humans; In Vitro Techniques; Interferons; Isoenzymes; Mice; Molecular Sequence Data; Oligonucleotide Probes; Phorbol Esters; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Signal Transduction; Tyrosine | 1994 |
Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Epidermal Growth Factor; Estradiol; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; In Vitro Techniques; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells.
Topics: Animals; Base Sequence; Binding Sites; Caseins; Cell Line; Cells, Cultured; Cytokines; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Epithelial Cells; Glucocorticoids; Insulin; Lactation; Macrophages; Mammary Glands, Animal; Mice; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Sequence Homology, Nucleic Acid; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Methylene Blue; Mice; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Oxyhemoglobins; Penicillamine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; S-Nitroso-N-Acetylpenicillamine; Tyrosine | 1995 |
Regulation of vascular and gastric smooth muscle contractility by pervanadate.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blotting, Western; Calcium; Epidermal Growth Factor; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sodium; Stomach; Tyrosine; Vanadates | 1994 |
Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells.
Topics: Animals; Asbestos, Crocidolite; Blotting, Northern; Cell Division; Cell Line; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Mesothelioma; Peritoneal Neoplasms; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Rats; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1995 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6).
Topics: Animals; Cell Count; Cell Division; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Genistein; Inositol Phosphates; Intestinal Mucosa; Isoenzymes; Isoflavones; Membrane Proteins; Phospholipase C gamma; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Type C Phospholipases; Tyrosine | 1995 |
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Glycoproteins; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Neuregulins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Lactation; Mice; Mice, Mutant Strains; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1995 |
Tyrosine phosphorylation in the human duodenum.
Topics: CD3 Complex; Celiac Disease; Duodenum; Edetic Acid; Epidermal Growth Factor; Flow Cytometry; Humans; Immunoenzyme Techniques; Phosphorylation; Phosphotyrosine; Tyrosine | 1995 |
Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation.
Topics: Alkaloids; Animals; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tyrosine; Up-Regulation | 1995 |
Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunohistochemistry; Kinetics; Mice; Phosphotyrosine; Placenta; Placental Lactogen; Pregnancy; Rats; Recombinant Proteins; Transforming Growth Factor alpha; Tyrosine | 1995 |
Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cesarean Section; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Kinetics; Myometrium; Oxytocin; Phosphorylation; Phosphotyrosine; Postpartum Period; Pregnancy; Ritodrine; Tyrosine | 1995 |
Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites.
Topics: Animals; Cell Division; Cell Line, Transformed; Cricetinae; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Linoleic Acid; Linoleic Acids; Mesocricetus; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1995 |
Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Topics: Animals; Base Sequence; Caseins; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Liver; Mice; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Processing, Post-Translational; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Indomethacin; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphotyrosine; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 1995 |
Insulin-like growth factor-1 enhances epidermal growth factor receptor activation and renal tubular cell regeneration in postischemic acute renal failure.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Blood Pressure; Body Weight; DNA; Epidermal Growth Factor; ErbB Receptors; Insulin-Like Growth Factor I; Iodine Radioisotopes; Ischemia; Kidney Medulla; Kidney Tubules; Male; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Regeneration; Renal Circulation; Tyrosine | 1995 |
Analysis of phosphorylhydroxyamino acids present in hydrolyzed cell extracts using dabsyl derivatization.
Topics: Cell Extracts; Chromatography, Thin Layer; Electrophoresis; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; p-Dimethylaminoazobenzene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Protein-Tyrosine Kinases; Quercetin; Tumor Cells, Cultured; Tyrosine | 1995 |
Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta.
Topics: Blotting, Western; Cell Membrane; Cell Nucleus; Choriocarcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; Immunosorbent Techniques; Microscopy, Immunoelectron; Nuclear Envelope; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Receptors, LH; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1995 |
Insulin stimulates the tyrosine phosphorylation of caveolin.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Blotting, Western; Caveolin 1; Caveolins; Epidermal Growth Factor; Insulin; Kinetics; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Polyethylene Glycols; Protein Binding; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein.
Topics: 3T3 Cells; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1995 |
Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.
Topics: Actins; Blotting, Western; Carcinoma, Squamous Cell; Cell Line; Cytochalasin D; Epidermal Growth Factor; Humans; Intercellular Junctions; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine; Zonula Occludens-1 Protein | 1995 |
Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.
Topics: Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, src; Immunoblotting; Mammary Neoplasms, Animal; Mice; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Effects of growth factors on phosphatidylinositol-3 kinase in astroglial cells.
Topics: Animals; Astrocytes; Epidermal Growth Factor; Growth Substances; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 1995 |
UV activation of receptor tyrosine kinase activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinase 1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Ultraviolet Rays | 1995 |
PC12-E2 cells: a stable variant with altered responses to growth factor stimulation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Growth Substances; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurites; PC12 Cells; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Transcription, Genetic; Tyrosine | 1995 |
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Isoenzymes; Kinetics; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Receptor, Insulin; Recombinant Proteins; Substrate Specificity; Transfection; Tyrosine | 1995 |
Inhibition by 5'-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas.
Topics: Antibodies; Cell Division; Cell Line; Cell Nucleus; Cross-Linking Reagents; Deoxyadenosines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factor 2; Glioblastoma; Glioma; Humans; Immunoblotting; Iodine Radioisotopes; Methyltransferases; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Thionucleosides; Tyrosine | 1995 |
Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Conserved Sequence; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Kinetics; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Recombinant Fusion Proteins; Type C Phospholipases; Tyrosine | 1993 |
Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Mitogens; Molecular Sequence Data; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1993 |
O-phospho-L-tyrosine inhibits cellular growth by activating protein tyrosine phosphatases.
Topics: Breast Neoplasms; Carcinoma, Renal Cell; Cell Death; Cell Division; Doxorubicin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Etoposide; Humans; Kidney Neoplasms; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine | 1993 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Topics: Breast Neoplasms; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Cell-free activation of a DNA-binding protein by epidermal growth factor.
Topics: 3T3 Cells; Animals; Cell Fractionation; Cell Line; Cell Membrane; Cell Nucleus; Cell-Free System; Cytosol; Dithiothreitol; DNA-Binding Proteins; Drosophila melanogaster; Epidermal Growth Factor; Genes, fos; Humans; Mice; Phosphotyrosine; Signal Transduction; Transcription, Genetic; Tyrosine; Ultracentrifugation | 1993 |
Gi alpha and Gi beta are part of a signalling complex in Balb/c3T3 cells: phosphorylation of Gi beta in growth-factor-activated fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Insulin; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1993 |
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.
Topics: Animals; Animals, Newborn; Carrier Proteins; Cell Membrane; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Kinetics; Liver; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Tyrosine | 1993 |
Protein kinases in divergent eukaryotes: identification of protein kinase activities regulated during trypanosome development.
Topics: Animals; Epidermal Growth Factor; Giardia lamblia; Humans; Isoenzymes; Kinetics; Phosphotyrosine; Protein Denaturation; Protein Kinases; Species Specificity; Trichomonas vaginalis; Trypanosoma brucei brucei; Tumor Cells, Cultured; Tyrosine | 1993 |
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Topics: Breast Neoplasms; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells.
Topics: Animals; Blotting, Western; Bronchi; Cell Division; Cell Line; Epidermal Growth Factor; Epithelium; Gene Expression; Humans; In Vitro Techniques; Ki-67 Antigen; Ligands; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tyrosine | 1993 |
Inhibition of EGF-induced vasoconstriction in isolated rabbit aortic rings with the tyrosine kinase inhibitor RG50864.
Topics: Animals; Aorta, Abdominal; Catechols; Dose-Response Relationship, Drug; Epidermal Growth Factor; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Tyrphostins; Vasoconstriction | 1993 |
Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Ethers, Cyclic; Gene Expression; Genes, fos; Glycosylation; Guanosine Triphosphate; Insulin; Nerve Growth Factors; Okadaic Acid; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
Changes of the phosphorylation of membrane-associated proteins following treatment of HeLa cells with the guanine analogue, queuine.
Topics: Adenosine Triphosphate; Epidermal Growth Factor; Guanine; HeLa Cells; Humans; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1993 |
The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Aggregation; Cell Movement; Cell Size; Epidermal Growth Factor; ErbB Receptors; Genistein; Hepatocyte Growth Factor; Isoflavones; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1993 |
Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.
Topics: Arachidonic Acid; Cells, Cultured; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrolysis; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Keratinocytes; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylcholines; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proteins; Transforming Growth Factor alpha; Type C Phospholipases; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Inhibitory effects of alpha-interferon on epidermal growth factor-mediated receptor-dependent events.
Topics: Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescein-5-isothiocyanate; Glioblastoma; Humans; Interferon Type I; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1993 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cobalt Radioisotopes; Confidence Intervals; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Up-Regulation | 1996 |
Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Fungal Proteins; GRB2 Adaptor Protein; Models, Biological; PC12 Cells; Phosphorylation; Phosphotyrosine; Potassium Chloride; Proteins; Rats; Repressor Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; SOS1 Protein; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1996 |
The uncoupling of Shc activation from distal intracellular signalling in a cell line which expresses a truncated human epidermal growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Myelin Basic Protein; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship | 1996 |
Growth factor-independent proliferation of rat mammary carcinoma cells by autocrine secretion of neu-differentiation factor/heregulin and transforming growth factor-alpha.
Topics: Animals; Base Sequence; Blotting, Western; Breast; Cell Division; Cell Line; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Culture Media, Conditioned; DNA Primers; Epidermal Growth Factor; Female; Glycoproteins; Growth Substances; Humans; Mammary Neoplasms, Experimental; Molecular Sequence Data; Neuregulins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Rats; Receptor, ErbB-2; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
Topics: Alleles; Aluminum Compounds; Animals; Animals, Newborn; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fluorides; Gene Expression; Genes, ras; GTP-Binding Proteins; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Signal Transduction; Spodoptera; Transfection; Transforming Growth Factor alpha; Tyrosine | 1996 |
Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Blotting, Western; Calcium-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblasts; Glucosidases; Humans; Intracellular Signaling Peptides and Proteins; Mammals; Membrane Proteins; Mice; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Subcellular Fractions | 1996 |
Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase activation by sodium salicylate.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Tumor Necrosis Factor; Sodium Salicylate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1996 |
Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Insulin; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Son of Sevenless Proteins; src Homology Domains | 1996 |
Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Cycle; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Humans; Macromolecular Substances; Membrane Proteins; Mice; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins p21(ras); ras Guanine Nucleotide Exchange Factors; Receptor, ErbB-2; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship | 1996 |
Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange.
Topics: Androstadienes; Animals; Cell Line; Cell Polarity; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Glucose; Humans; Intestinal Absorption; Intestinal Mucosa; Isoflavones; Microvilli; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Sodium Chloride; Sodium-Hydrogen Exchangers; Transfection; Wortmannin | 1996 |
Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Cell Differentiation; Crk-Associated Substrate Protein; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Nerve Growth Factors; Oncogene Protein v-crk; PC12 Cells; Peptide Fragments; Pheochromocytoma; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Rats; Recombinant Fusion Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Tyrosine | 1996 |
An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Base Sequence; Breast Neoplasms; Cell Differentiation; CHO Cells; Clone Cells; Cricetinae; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; Hybridomas; Immunohistochemistry; Intercellular Adhesion Molecule-1; Macromolecular Substances; Mammals; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neuregulins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-3; Receptor, ErbB-4; Restriction Mapping; Transfection; Tumor Cells, Cultured | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
Alterations in the level of phosphotyrosine signal transduction constituents in human parotid tumors.
Topics: Base Sequence; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Humans; Molecular Sequence Data; Parotid Neoplasms; Phosphotyrosine; Polymerase Chain Reaction; Protein Kinase C; Receptor, ErbB-2; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha | 1996 |
Epidermal growth factor-mediated inhibition of neurotransmitter glutamate release from rat forebrain synaptosomes.
Topics: 4-Aminopyridine; Animals; Calcium; Epidermal Growth Factor; Glutamic Acid; Insulin; Insulin-Like Growth Factor I; Male; Phosphorylation; Phosphotyrosine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Synaptosomes | 1996 |
Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Line; Cell Nucleus; Cloning, Molecular; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Male; Membrane Transport Proteins; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Structure, Secondary; RNA, Messenger; src Homology Domains; Testis; Type C Phospholipases; Vanadates; Zinc Fingers | 1996 |
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Glutathione Transferase; GRB2 Adaptor Protein; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Binding; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Ubiquitin-Protein Ligases | 1996 |
Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor.
Topics: Animals; Bradykinin; Cell Line; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Insulin-Like Growth Factor I; Kidney; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Recombinant Proteins; Skin; Transfection; Tyrosine | 1996 |
Fluoride at mitogenic concentrations increases the steady state phosphotyrosyl phosphorylation level of cellular proteins in human bone cells.
Topics: Bone and Bones; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fluorides; Humans; Immunoblotting; Kinetics; Molecular Weight; Osteosarcoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured | 1996 |
The intracellular functions of alpha6beta4 integrin are regulated by EGF.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antigens, CD; Cell Adhesion; Cell Movement; Cell Polarity; Cells, Cultured; Desmosomes; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Integrin alpha6; Integrin beta4; Ligands; Phosphorylation; Phosphotyrosine; Proteins; Receptors, Laminin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1996 |
Genistein, a tyrosine kinase inhibitor, reduces EGF-induced EGF receptor internalization and degradation in human hepatoma HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1996 |
The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
Topics: Amphiregulin; Animals; Cell Division; Cell Line; Cell Survival; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-3; Mice; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Transforming Growth Factor alpha | 1996 |
PC12h-R cell, a subclone of PC12 cells, shows EGF-induced neuronal differentiation and sustained signaling.
Topics: Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Survival; Clone Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Pheochromocytoma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Signal Transduction | 1996 |
Elevation of intracellular cyclic adenosine monophosphate inhibits the epidermal growth factor signal transduction pathway and cellular growth in pancreatic adenocarcinoma cell lines.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Division; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured | 1996 |
An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells.
Topics: Antibodies, Monoclonal; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Guanine Nucleotides; Humans; Molecular Sequence Data; Mutation; Pancreatic Neoplasms; Phosphotyrosine; ras Proteins; RNA, Messenger; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; DNA-Binding Proteins; Epidermal Growth Factor; Growth Hormone; Humans; Insulin Receptor Substrate Proteins; Janus Kinase 2; Kinetics; Liver; Male; Milk Proteins; Molecular Weight; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT5 Transcription Factor; Time Factors; Trans-Activators | 1996 |
Detection of EGF-induced EGF receptor degradation and tyrosine phosphorylation in intact cells.
Topics: Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Liver; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Time Factors; Tyrosine | 1996 |
Effects of mitogens on androgen receptor-mediated transactivation.
Topics: Animals; Cell Line; COS Cells; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; HeLa Cells; Insulin-Like Growth Factor I; Intracellular Membranes; Isoflavones; Ligands; Mitogens; Phosphorylation; Phosphotyrosine; Rats; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Tyrosine; Vanadates | 1996 |
EGF-induced sustained tyrosine phosphorylation and decreased rate of down-regulation of EGF receptor in PC12h-R cells which show neuronal differentiation in response to EGF.
Topics: Acetylcholinesterase; Animals; Cell Differentiation; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Immunosorbent Techniques; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases | 1996 |
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
Topics: Actins; Androstadienes; Animals; Cell Division; Cell Line; Cytoskeleton; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Transfection; Wortmannin | 1996 |
Parietal cell MAP kinases: multiple activation pathways.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cyclic AMP; Cytosol; Enzyme Activation; Epidermal Growth Factor; Gastric Mucosa; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parasympathomimetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
The mitogenic response to EGF of rat hepatocytes cultured on laminin-rich gels (EHS) is blocked downstream of receptor tyrosine-phosphorylation.
Topics: Animals; Cell Division; Cells, Cultured; Culture Techniques; DNA; Epidermal Growth Factor; ErbB Receptors; Gels; Hepatocyte Growth Factor; Humans; Kinetics; Laminin; Liver; Phosphorylation; Phosphotyrosine; Rats; Recombinant Proteins; Serum Albumin; Transforming Growth Factor beta | 1996 |
EGF receptor mRNA and protein in rat lacrimal acinar cells: evidence of its EGF-dependent phosphotyrosilation.
Topics: Animals; Antisense Elements (Genetics); Base Sequence; Blotting, Northern; Epidermal Growth Factor; ErbB Receptors; Lacrimal Apparatus; Male; Molecular Sequence Data; Oligonucleotide Probes; Phosphotyrosine; Polymerase Chain Reaction; Precipitin Tests; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1996 |
Plasma membrane phosphotyrosine, Her2-NEU, and epidermal growth factor receptor in human breast cancer. A comparative study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Fixatives; Formaldehyde; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Middle Aged; Neoplasm Staging; Oncogenes; Paraffin Embedding; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Tissue Fixation; Tumor Cells, Cultured | 1996 |
The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Calcium; Carrier Proteins; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Humans; Isoenzymes; Mice; Neuregulin-1; Phospholipase C gamma; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Type C Phospholipases | 1996 |
Phospholipase C-gamma 1 binds to actin-cytoskeleton via its C-terminal SH2 domain in vitro.
Topics: Actins; Animals; Binding Sites; Chickens; Cytoskeleton; Epidermal Growth Factor; Isoenzymes; Liver; Male; Mice; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; src Homology Domains; Type C Phospholipases | 1996 |
Effect of epidermal growth factor on phosphatidylinositol 3-kinase activity in rabbit corneal epithelial cells.
Topics: Androstadienes; Animals; Cells, Cultured; Cornea; Epidermal Growth Factor; Epithelium; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Polyethylene Glycols; Rabbits; Wortmannin | 1996 |
Control of EGF receptor signaling by clathrin-mediated endocytosis.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Membrane; Clathrin; Coated Pits, Cell-Membrane; Dynamins; Endocytosis; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GTP Phosphohydrolases; HeLa Cells; Humans; Isoenzymes; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases | 1996 |
Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen Peroxide; Phosphorylation; Phosphotyrosine; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 1997 |
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fibroblasts; Humans; Immunosorbent Techniques; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mitogens; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1997 |
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Neoplasms; Cell Line; DNA Primers; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Glioblastoma; Humans; Mice; Mice, Nude; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Signal Transduction; Transfection; Transplantation, Heterologous | 1997 |
Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Insulin Receptor Substrate Proteins; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Proteins; Rats; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains | 1997 |
Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Middle Aged; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Estrogen; RNA, Neoplasm; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | 1997 |
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Blotting, Western; Cells, Cultured; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Microscopy, Fluorescence; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein Binding; Protein Tyrosine Phosphatases; Substrate Specificity; Transfection | 1997 |
Extracellular matrix is required for MAP kinase activation and proliferation of rat glomerular epithelial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Extracellular Matrix; Flavonoids; Kidney Glomerulus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Plastics; Rats; Tetradecanoylphorbol Acetate | 1997 |
Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; COS Cells; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Mice; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Proteins; Signal Transduction; src Homology Domains | 1997 |
Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion.
Topics: Animals; Carcinogens; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Epidermis; ErbB Receptors; Female; Keratinocytes; Mice; Mice, Transgenic; Phorbol Esters; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Receptor Aggregation; Receptor, ErbB-2; Signal Transduction; Skin Neoplasms; Transforming Growth Factor alpha | 1997 |
Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells.
Topics: Adult; Aged; Cell Adhesion Molecules; Epidermal Growth Factor; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Male; Middle Aged; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, ErbB-2; Survival Rate; Tumor Cells, Cultured | 1997 |
Insulin-like growth factor I receptor signaling in transformation by src oncogenes.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Adhesion Molecules; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Insulin Receptor Substrate Proteins; Mice; Oncogenes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; Trans-Activators; Transfection | 1997 |
Mechanisms of inhibition by heparin of PDGF stimulated MAP kinase activation in vascular smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Heparin; Mitogens; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Signal Transduction | 1997 |
Cytoskeletal association of epidermal growth factor receptor and associated signaling proteins is regulated by cell density in IEC-6 intestinal cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Count; Cells, Cultured; Cytoskeleton; Epidermal Growth Factor; Epithelium; ErbB Receptors; Intestinal Mucosa; Phosphotyrosine; Proteins; Rats; Second Messenger Systems; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases | 1997 |
CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line.
Topics: Amnion; Aprotinin; CA-125 Antigen; Cell Line; Cytoplasm; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Hydrolysis; Immunohistochemistry; Phosphorylation; Phosphotyrosine; Signal Transduction; Vanadates | 1997 |
Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Drug Stability; Epidermal Growth Factor; Hydroquinones; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats | 1997 |
Critical role of calcium- dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling.
Topics: Animals; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cytomegalovirus; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Membrane Potentials; Nerve Growth Factors; Neurons; PC12 Cells; Phosphotyrosine; Promoter Regions, Genetic; Rats; Signal Transduction; Tetracycline; Transcriptional Activation | 1997 |
Growth hormone attenuation of epidermal growth factor-induced mitogenesis.
Topics: 3T3 Cells; Animals; Cell Cycle; Cyclin D; Cyclins; DNA; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Human Growth Hormone; Humans; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; S Phase; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Catechin; Cell Division; DNA, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tea; Tumor Cells, Cultured | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
EGF receptor phosphorylation is affected by ionizing radiation.
Topics: Adenosine Triphosphate; Cell Division; Cell Line; Cell Membrane; Cesium Radioisotopes; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Gamma Rays; Humans; Kinetics; Methionine; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1997 |
Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factors; GRB2 Adaptor Protein; Growth Substances; Humans; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proteins; src Homology Domains | 1997 |
TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells.
Topics: Cell Division; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Respiratory System; Ribosomal Protein S6 Kinases; Transforming Growth Factor beta | 1997 |
Effects of protein tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth.
Topics: Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Female; Insulin; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; COS Cells; Cytoplasm; Endoplasmic Reticulum; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Substrate Specificity; Tyrosine | 1998 |
Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation.
Topics: Carcinoma, Hepatocellular; Catechols; Cell Division; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Humans; Kinetics; Liver Neoplasms; Mercaptoethanol; Naphthoquinones; Nitriles; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sulfhydryl Compounds; Tumor Cells, Cultured; Tyrphostins; Vanadates; Vitamin K | 1998 |
Antagonistic regulation of cell migration by epidermal growth factor and glucocorticoid in human gastric carcinoma cells.
Topics: Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Collagen; Dexamethasone; Epidermal Growth Factor; Extracellular Matrix; Flow Cytometry; Glucocorticoids; Humans; Immunohistochemistry; Integrins; Laminin; Phosphotyrosine; Stomach Neoplasms; Tumor Cells, Cultured | 1998 |
Neurofibromatosis type 2: growth stimulation of mixed acoustic schwannoma by concurrent adjacent meningioma: possible role of growth factors. Case report.
Topics: Adolescent; Autocrine Communication; Cerebellar Neoplasms; Cerebellopontine Angle; Epidermal Growth Factor; Follow-Up Studies; Humans; Immunoblotting; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Neurofibromatosis 2; Neuroma, Acoustic; Paracrine Communication; Phosphotyrosine; Sella Turcica | 1998 |
ERK2 signalling from internalised epidermal growth factor receptor in broken A431 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen-Ion Concentration; Mitogen-Activated Protein Kinase 1; Phosphorylation; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured | 1998 |
Transforming growth factor-beta inhibits proliferation and maturation of cultured guinea pig gastric pit cells.
Topics: Animals; Biological Transport; Cell Division; Cells, Cultured; Cytoplasmic Granules; Epidermal Growth Factor; ErbB Receptors; Gastric Mucosa; Gene Expression Regulation; Genes, fos; Genes, myc; Glucosamine; Guinea Pigs; Kinetics; Male; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Transcription, Genetic; Transforming Growth Factor beta | 1998 |
Synergistic regulation of Schwann cell proliferation by heregulin and forskolin.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Division; Colforsin; Cyclin D; Cyclins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Molecular Sequence Data; Neuregulin-1; Peptide Fragments; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptor, ErbB-3; Retinoblastoma Protein; Ribosomal Protein S6 Kinases; Schwann Cells | 1998 |
Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; B-Lymphocytes; Binding Sites; Cell Membrane; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Kinetics; Ligands; Mice; Models, Molecular; Mutation; Phosphorylation; Phosphotyrosine; Protein Structure, Secondary | 1998 |
Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells.
Topics: Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Humans; Kidney; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Regulation of the renal Na-HCO3 cotransporter: IX. Modulation by insulin, epidermal growth factor and carbachol.
Topics: Aminobenzoates; Animals; Antibodies; Carrier Proteins; Cells, Cultured; Cinnamates; Enzyme Activation; Epidermal Growth Factor; Genistein; Insulin; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Membrane Proteins; meta-Aminobenzoates; Peptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Salicylates; Sodium-Bicarbonate Symporters | 1998 |
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Epidermal Growth Factor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Progesterone; Promegestone; Receptor Cross-Talk; Receptors, Growth Factor; Signal Transduction; Up-Regulation | 1998 |
Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Guanosine Triphosphate; Humans; Mice; Mitogens; Mutation; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1998 |
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cell Membrane; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Models, Biological; Morpholines; Neurites; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transfection; Tumor Cells, Cultured; Wortmannin | 1998 |
Probing cellular protein targets of H2O2 with fluorescein-conjugated iodoacetamide and antibodies to fluorescein.
Topics: Antibodies; Blotting, Western; Catecholamines; Cysteine; Epidermal Growth Factor; Fluoresceins; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Imidazolines; Molecular Weight; Oxidants; Oxidation-Reduction; Papain; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Proteins; Substrate Specificity; Tumor Cells, Cultured | 1998 |
Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor beta-receptor (beta-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases.
Topics: 3T3 Cells; Animals; Becaplermin; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Growth Substances; Humans; Indoles; Kinetics; Mice; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1999 |
Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Carbachol; Cell Adhesion Molecules; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Humans; Neuroblastoma; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, Muscarinic M3; Receptors, Muscarinic; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.
Topics: Animals; Cell Line; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Gene Expression; Humans; Immunohistochemistry; Kinetics; Lysosomes; Mice; Phosphotyrosine; Receptor, ErbB-2; Signal Transduction; Transfection | 1999 |
Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.
Topics: Animals; Cell Line; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Isoenzymes; Lysosomes; Mice; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Signal Transduction; Transforming Growth Factor alpha; Type C Phospholipases | 1999 |
Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation.
Topics: Animals; Calcium Signaling; Cell Division; Cells, Cultured; Cytoskeleton; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethanol; Isoenzymes; Liver; Male; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Quinazolines; Rats; Rats, Wistar; Type C Phospholipases; Tyrphostins | 1999 |
Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration.
Topics: ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibronectins; Gelatin; Integrin beta1; Lysophospholipids; Mice; Mutation; Pertussis Toxin; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Virulence Factors, Bordetella; Vitronectin | 1999 |
The insulin receptor tyrosine kinase domain in a chimaeric epidermal growth factor-insulin receptor generates Ca2+ signals through the PLC-gamma1 pathway.
Topics: Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Isoenzymes; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Substrate Specificity; Transfection; Type C Phospholipases | 1999 |
Spatial organization of EGF receptor transmodulation by PDGF.
Topics: Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genistein; Humans; Immunosorbent Techniques; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship | 1999 |
Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.
Topics: Actins; Antigens, Surface; Carbazoles; Carcinoma, Squamous Cell; Cell Membrane; Cell Size; Chemotaxis; Desmosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Integrin alpha6beta4; Integrins; Keratins; Laminin; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Pseudopodia; Signal Transduction; Tumor Cells, Cultured | 1999 |
Neuregulin stimulates DNA synthesis in embryonic chick heart cells.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; DNA; Endocardium; Epidermal Growth Factor; Gene Expression Regulation, Developmental; Heart; In Situ Hybridization; Myocardium; Neuregulin-1; Phosphorylation; Phosphotyrosine; Recombinant Proteins; RNA, Messenger; Thymidine; Transcription, Genetic | 1999 |
Regulation of EGF signaling by cell polarity in MDCK kidney epithelial cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Membrane; Cell Polarity; Dogs; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GRB2 Adaptor Protein; Humans; Kidney; Mitogen-Activated Protein Kinases; Phosphotyrosine; Proteins; Recombinant Proteins; Signal Transduction; Transfection | 1999 |
Growth factors stimulate the activity of key glycolytic enzymes in isolated digestive gland cells from mussels (Mytilus galloprovincialis Lam.) through tyrosine kinase mediated signal transduction.
Topics: Animals; Antibodies, Monoclonal; Bivalvia; Digestive System; Enzyme Activation; Epidermal Growth Factor; Glycolysis; Growth Substances; Insulin; Insulin-Like Growth Factor I; Microscopy, Immunoelectron; Phosphofructokinase-1; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvate Kinase; Signal Transduction | 1999 |
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Kidney; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Opossums; Parathyroid Hormone; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1999 |
Identification of EPS8 as a Dvl1-associated molecule.
Topics: Acid Phosphatase; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Central Nervous System; Cytoskeletal Proteins; Dishevelled Proteins; Embryonic and Fetal Development; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Immunohistochemistry; Mice; Organ Specificity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Proteins; Recombinant Fusion Proteins; Transfection; Two-Hybrid System Techniques | 1999 |
Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442A fibroblasts.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Antibodies; Cyclin D1; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Growth Inhibitors; Human Growth Hormone; Humans; Interleukin-6; Janus Kinase 2; Leukemia Inhibitory Factor; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Recombinant Proteins | 1999 |
Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells.
Topics: Cell Adhesion; Cell Division; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kinetics; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogenes; src Homology Domains; Tumor Cells, Cultured | 1999 |
A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Epidermal Growth Factor; ErbB Receptors; Follistatin; Gastric Mucosa; Glycoproteins; Growth Substances; Humans; Membrane Proteins; Mice; Molecular Sequence Data; Neoplasm Proteins; Nerve Tissue Proteins; Phosphorylation; Phosphotyrosine; Protein Isoforms; Receptor, ErbB-4; RNA, Messenger; Sequence Alignment; Transfection; Tumor Cells, Cultured | 1999 |
Bradykinin-induced inhibition of cell proliferation and tyrosine kinase activity in rat mesangial cells.
Topics: Angiotensin II; Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium; Cell Division; Cells, Cultured; Cyclic AMP; Epidermal Growth Factor; Estrenes; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glomerular Mesangium; Insulin; Pertussis Toxin; Phospholipases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrrolidinones; Rats; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Time Factors; Virulence Factors, Bordetella | 2000 |
Differentiation of chick lens epithelial cells: involvement of the epidermal growth factor receptor and endogenous ligand.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Chickens; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Eye Proteins; Intermediate Filament Proteins; Lens, Crystalline; Ligands; Phosphotyrosine; Transforming Growth Factor alpha | 2000 |
The internalization and endosomal trafficking of the EGF receptor in response to EGF is delayed in the waved-2 mouse liver.
Topics: Animals; Crosses, Genetic; Endosomes; Epidermal Growth Factor; ErbB Receptors; Female; Heterozygote; Homozygote; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphotyrosine; Point Mutation | 2000 |
Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Enzyme Activation; Epidermal Growth Factor; Female; Genetic Vectors; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphotyrosine; Recombinant Proteins; Retroviridae; Signal Transduction; Transfection | 2000 |
The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF.
Topics: Animals; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Flavonoids; Immunoblotting; Immunohistochemistry; Mesoderm; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morphogenesis; Phosphorylation; Phosphotyrosine; Signal Transduction; Submandibular Gland; Time Factors | 2000 |
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
Topics: Binding Sites; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphates; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotyrosine; Platelet-Derived Growth Factor; Receptor, ErbB-2; Receptors, Platelet-Derived Growth Factor; Tumor Cells, Cultured | 2000 |
Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity.
Topics: Animals; Cell Nucleus; COS Cells; DNA; DNA-Binding Proteins; Epidermal Growth Factor; HeLa Cells; Humans; Immunoblotting; Luciferases; Mice; Phosphorylation; Phosphotyrosine; Protein Binding; Recombinant Fusion Proteins; Replication Protein A; src Homology Domains; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Transfection; Two-Hybrid System Techniques | 2000 |
Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Culture Media; Cytokines; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Inflammation Mediators; Oncostatin M; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Time Factors; Tumor Cells, Cultured; Tyrosine | 2000 |
Evidence for the involvement of two pathways in activation of extracellular signal-regulated kinase (Erk) and cell proliferation by Gi and Gq protein-coupled receptors in osteoblast-like cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Division; Cell Line; Dinoprost; DNA; Enzyme Activation; Epidermal Growth Factor; GRB2 Adaptor Protein; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyrimidines; Receptors, Cell Surface; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Virulence Factors, Bordetella | 2000 |
Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Line; Cytokines; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; Genes, myc; Growth Substances; HeLa Cells; Humans; Interleukin-3; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Isoforms; Receptors, Cytokine; Receptors, Growth Factor; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2000 |
Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; Gene Expression; GRB2 Adaptor Protein; Homeodomain Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Proteins v-abl; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Son of Sevenless Proteins; SOS1 Protein; src Homology Domains; Transfection; Two-Hybrid System Techniques | 2000 |
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate.
Topics: Amino Acid Sequence; Androstadienes; Animals; Cell Line; Cricetinae; Cytosol; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; Fluorescent Antibody Technique; HeLa Cells; Humans; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein Transport; Receptors, Cell Surface; Signal Transduction; Transfection; Wortmannin | 2000 |
Regulation of STAT3 by direct binding to the Rac1 GTPase.
Topics: Amino Acid Substitution; Animals; Cell Line; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Guanine Nucleotide Exchange Factors; Humans; Janus Kinase 2; Mutation; Neoplasm Proteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; rac1 GTP-Binding Protein; Rats; Signal Transduction; STAT3 Transcription Factor; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Trans-Activators; Transfection; Two-Hybrid System Techniques | 2000 |
The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin.
Topics: Acetylglucosamine; Animals; beta Catenin; Blotting, Western; Cadherins; Carbohydrate Sequence; Cell Size; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Glycosylation; Mice; Microscopy, Fluorescence; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Phosphorylation; Phosphotyrosine; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; src-Family Kinases; Trans-Activators; Transfection; Tumor Cells, Cultured; Tunicamycin | 2001 |
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anisomycin; Cell Differentiation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2000 |
Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Down-Regulation; Endocytosis; Endosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, Dominant; Guanosine Triphosphate; Humans; Membrane Proteins; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Isoforms; rab5 GTP-Binding Proteins; Signal Transduction; Substrate Specificity; Transfection; Vesicular Transport Proteins | 2000 |
Regulation by ceramide of epidermal growth factor signal transduction and mitogenesis in cell lines overexpressing the growth factor receptor.
Topics: Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Ceramides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Mitogens; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2000 |
Cholecystokinin does not affect the pancreatic contents of epidermal growth factor or its receptor.
Topics: Animals; Body Weight; Bromodeoxyuridine; Cholecystokinin; Epidermal Growth Factor; ErbB Receptors; Immunohistochemistry; In Situ Hybridization; Male; Organ Size; Pancreas; Phosphotyrosine; Rats; Rats, Sprague-Dawley | 2000 |
Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane.
Topics: Arsenicals; Carbocyanines; Cell Membrane; Diffusion; Dimerization; Endocytosis; Energy Transfer; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence; Fluorescent Dyes; Green Fluorescent Proteins; Humans; Immunoglobulin Fab Fragments; Ligands; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Microspheres; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Signal Transduction; Tumor Cells, Cultured | 2000 |
Nitric oxide stimulates tyrosine phosphorylation of focal adhesion kinase, Src kinase, and mitogen-activated protein kinases in murine fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Animals; Buthionine Sulfoximine; Cell Line; Epidermal Growth Factor; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Signal Transduction; src-Family Kinases; Triazenes | 2000 |
Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode.
Topics: Amino Acid Sequence; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mass Spectrometry; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Signal Transduction; Tyrosine | 2001 |
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
Topics: Amino Acid Motifs; Animals; Binding Sites; COS Cells; Cysteine; Enzyme Activation; Epidermal Growth Factor; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mutation; Peptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins | 2001 |
Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase.
Topics: Adenosine Diphosphate Ribose; Alternative Splicing; Base Sequence; Cell Division; Endometrial Neoplasms; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Genes, fos; Gonadotropin-Releasing Hormone; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Humans; Molecular Sequence Data; Mutation; Ovarian Neoplasms; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptors, LHRH; RNA, Messenger; Sequence Analysis, DNA; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Size; Epidermal Growth Factor; ErbB Receptors; Female; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Ligands; Neuregulin-1; Phosphorylation; Phosphotyrosine; Receptor, ErbB-2; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2001 |
Heregulin-dependent translocation and hyperphosphorylation of ErbB-2.
Topics: Betacellulin; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Neuregulin-1; Phosphorylation; Phosphotyrosine; Protein Transport; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tumor Cells, Cultured | 2001 |
Human VPS34 is required for internal vesicle formation within multivesicular endosomes.
Topics: Androstadienes; Antibodies, Monoclonal; Autocrine Communication; Carcinoma, Hepatocellular; Coated Vesicles; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Microinjections; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Transport; Tumor Cells, Cultured; Wortmannin | 2001 |
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Becaplermin; Binding, Competitive; Chlorocebus aethiops; COS Cells; CSK Tyrosine-Protein Kinase; Epidermal Growth Factor; Fibroblast Growth Factor 2; Humans; Insulin-Like Growth Factor I; Kinetics; LDL-Receptor Related Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Subunits; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rabbits; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; src-Family Kinases; Surface Plasmon Resonance; Transfection | 2002 |
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Biological Transport; Cell Nucleus; COS Cells; Cytoplasm; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescent Antibody Technique; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Microscopy, Confocal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2002 |
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, Viral, Tumor; Cell Line; DNA; Epidermal Growth Factor; GRB2 Adaptor Protein; Humans; Insulin; Insulin-Like Growth Factor I; Intramolecular Transferases; Macromolecular Substances; Mitogen-Activated Protein Kinases; Mitogens; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins c-raf; Rats; Signal Transduction; Swine | 2002 |
Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.
Topics: Carrier Proteins; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; KB Cells; Membrane Microdomains; Membrane Proteins; Phospholipid Transfer Proteins; Phospholipids; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-abl | 2002 |
Phosphorylation of Hrs downstream of the epidermal growth factor receptor.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; CSK Tyrosine-Protein Kinase; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; HeLa Cells; Humans; Liver Neoplasms; Mice; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2002 |
Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Electric Impedance; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gastric Mucosa; Mannitol; Parietal Cells, Gastric; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinazolines; Secretin; src-Family Kinases; Tyrphostins | 2002 |
Development of a time-resolved fluorescent assay for measuring tyrosine-phosphorylated proteins in cells.
Topics: Animals; Antibodies, Monoclonal; Biotinylation; Blotting, Western; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Europium; Fluoroimmunoassay; Insulin; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Tumor Cells, Cultured | 2002 |
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cytoplasm; Epidermal Growth Factor; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-fos; Receptor Protein-Tyrosine Kinases; Signal Transduction | 2002 |
Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Antigens, CD; Carrier Proteins; Cytokine Receptor gp130; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Immunoblotting; Indoles; Janus Kinase 2; Maleimides; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction; Transfection; Ubiquitin-Protein Ligases | 2003 |
Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.
Topics: Adult; Body Mass Index; Deoxyglucose; Enzyme Activation; Epidermal Growth Factor; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Obesity; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2003 |
Nitric oxide-induced epidermal growth factor-dependent phosphorylations in A431 tumour cells.
Topics: Carcinoma, Squamous Cell; DNA, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrazines; Kinetics; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Thymidine; Tumor Cells, Cultured | 2003 |
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes.
Topics: Animals; Cell Division; Cells, Cultured; DNA; DNA-Binding Proteins; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Growth Hormone; Hepatocytes; Male; Milk Proteins; Mitogens; Phosphorylation; Phosphoserine; Phosphotyrosine; Prolactin; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Pyrroles; Rats; Rats, Wistar; STAT5 Transcription Factor; Trans-Activators; Transforming Growth Factor alpha | 2003 |
Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Cell Separation; Cytokines; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erythropoietin; Flow Cytometry; Hematopoietic Stem Cells; Mice; Milk Proteins; Models, Genetic; Mutation; Phosphotyrosine; Proto-Oncogene Proteins c-kit; Receptors, Erythropoietin; Retroviridae; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Local signaling by the EGF receptor.
Topics: Actin Depolymerizing Factors; Actins; Androstadienes; Animals; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Microfilament Proteins; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA, Small Interfering; Signal Transduction; Wortmannin | 2003 |
The UIM domain of Hrs couples receptor sorting to vesicle formation.
Topics: Biological Transport; Clathrin; Coated Pits, Cell-Membrane; Cryoelectron Microscopy; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mass Spectrometry; Microscopy, Fluorescence; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Ubiquitin | 2003 |
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion; Cell Size; Crk-Associated Substrate Protein; Epidermal Growth Factor; ErbB Receptors; Fibronectins; HeLa Cells; Humans; Integrins; Mice; Molecular Sequence Data; Neuroblastoma; Phosphotyrosine; Proteins; Rats; Retinoblastoma-Like Protein p130; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2004 |
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mutation; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; src-Family Kinases; Transfection; Tumor Cells, Cultured | 2004 |
Overexpression of profilin reduces the migration of invasive breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Contractile Proteins; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Green Fluorescent Proteins; Humans; Luminescent Proteins; Microfilament Proteins; Phosphoproteins; Phosphotyrosine; Profilins; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Transfection | 2004 |
Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Caspase 3; Caspases; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Gene Deletion; Heat-Shock Response; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Ultraviolet Rays | 2004 |
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal; Cell Adhesion; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2 | 2004 |
Use of high affinity insulin analogues to assess the functional relationships between insulin receptor trafficking, mitogenic signaling and mRNA expression in rat liver.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Insulin; Kinetics; Ligands; Liver; MAP Kinase Signaling System; Phosphotyrosine; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, Insulin; RNA, Messenger; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2004 |
Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3.
Topics: Actins; Amino Acid Sequence; Cell Line, Tumor; Cloning, Molecular; Crk-Associated Substrate Protein; DNA, Complementary; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Profiling; Humans; Microfilament Proteins; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Sequence Analysis, Protein; src-Family Kinases; Tensins | 2004 |
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.
Topics: Binding Sites; Cell Line; Epidermal Growth Factor; ErbB Receptors; Evolution, Molecular; Humans; Ligands; Membrane Glycoproteins; Oncogene Proteins v-erbB; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; RNA, Messenger; Signal Transduction; Substrate Specificity; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.
Topics: Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; HeLa Cells; Humans; Isotope Labeling; Kinetics; Mass Spectrometry; Oxidative Phosphorylation; Phosphotyrosine; Proteome; Proteomics; Signal Transduction; Time Factors | 2004 |
Phosphoproteomics finds its timing.
Topics: Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; HeLa Cells; Humans; Isotope Labeling; Kinetics; Mass Spectrometry; Oxidative Phosphorylation; Phosphotyrosine; Proteome; Proteomics; Signal Transduction | 2004 |
A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation.
Topics: Animals; Antibodies, Monoclonal; Benzamides; Cells, Cultured; Epidermal Growth Factor; Fluorescent Dyes; Fusion Proteins, bcr-abl; HeLa Cells; Humans; Imatinib Mesylate; Mass Spectrometry; Phosphorylation; Phosphotyrosine; Piperazines; Protein Array Analysis; Protein-Tyrosine Kinases; Proteome; Pyrimidines; Signal Transduction | 2004 |
Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Caveolin 2; Caveolins; Cell Line, Transformed; Cell Line, Tumor; COS Cells; Epidermal Growth Factor; Humans; Membrane Microdomains; Mice; Molecular Weight; NIH 3T3 Cells; Oncogene Proteins; Phosphorylation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; src Homology Domains; Subcellular Fractions; Transfection | 2004 |
Srcasm modulates EGF and Src-kinase signaling in keratinocytes.
Topics: Adaptor Proteins, Signal Transducing; Cell Differentiation; Cell Proliferation; Cells, Cultured; DNA; DNA Replication; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; ets-Domain Protein Elk-1; Filaggrin Proteins; Gene Expression Regulation; Humans; Intermediate Filament Proteins; Keratinocytes; Ligands; Mitogen-Activated Protein Kinase 1; Models, Biological; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Response Elements; Signal Transduction; src-Family Kinases; Transcription Factors; Transcription, Genetic | 2005 |
Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation.
Topics: Amlodipine; Animals; Cardiomegaly; Cells, Cultured; Epidermal Growth Factor; Epinephrine; ErbB Receptors; Heparin; Male; Mice; Myocardium; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Rats | 2005 |
Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers.
Topics: Animals; Cell Line; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Kidney; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Oxidants; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Sodium; src Homology Domains; Xenopus laevis | 2005 |
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aged; Blotting, Western; Bronchi; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epithelial Cells; Female; Humans; Male; Middle Aged; Mucin 5AC; Mucins; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Recombinant Proteins; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation.
Topics: Cell Adhesion; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Immunoprecipitation; Integrins; Peptide Fragments; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1.
Topics: Adaptor Proteins, Signal Transducing; Calcium; Cell Line; Epidermal Growth Factor; Gene Expression; GRB2 Adaptor Protein; Humans; Inositol 1,4,5-Trisphosphate; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; ras Proteins; RNA, Small Interfering; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 2005 |
Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sodium-Hydrogen Exchangers; src-Family Kinases; TRPC Cation Channels | 2005 |
Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP-dependent protein kinase A.
Topics: Animals; Cell Adhesion; Cell Shape; Cells, Cultured; Collagen Type I; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; DNA; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Hepatocytes; Microscopy, Electron, Scanning; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphotyrosine; Protein Kinase Inhibitors; Rats; Signal Transduction | 2006 |
Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.
Topics: Animals; Carrier Proteins; Chlorocebus aethiops; COS Cells; Dimerization; Epidermal Growth Factor; Humans; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; Sorting Nexins; Vesicular Transport Proteins | 2006 |
Src homology 2 domain-based high throughput assays for profiling downstream molecules in receptor tyrosine kinase pathways.
Topics: Amino Acid Sequence; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Microspheres; Molecular Sequence Data; Phosphopeptides; Phosphotyrosine; Protein Interaction Mapping; Receptor Protein-Tyrosine Kinases; Sensitivity and Specificity; Signal Transduction; src Homology Domains; Substrate Specificity | 2006 |
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
Topics: 3T3 Cells; Alanine; Animals; Butadienes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Janus Kinase 2; MAP Kinase Kinase 1; Mass Spectrometry; Mice; Mutation; Nitriles; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Repressor Proteins; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.
Topics: Algorithms; Breast; Cell Division; Cell Line; Cell Movement; Dimerization; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Female; Gene Expression; Genes, erbB-1; Genes, erbB-2; Humans; Least-Squares Analysis; Mass Spectrometry; Neuregulin-1; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction | 2006 |
Towards comprehensive characterization of HER2 overexpression.
Topics: Breast; Cell Division; Cell Line; Cell Movement; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Female; Gene Expression; Genes, erbB-1; Genes, erbB-2; Humans; Mass Spectrometry; Neuregulin-1; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction | 2006 |
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Topics: Binding Sites; Databases, Factual; Epidermal Growth Factor; HeLa Cells; Humans; Kinetics; Mass Spectrometry; Neoplasm Proteins; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Proteome; Signal Transduction | 2006 |
Epidermal growth factor receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation.
Topics: Animals; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Mice; Molecular Weight; Mutant Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-cbl; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Protein Ligases | 2007 |
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.
Topics: Animals; Cell Movement; Chlorocebus aethiops; Colon; COS Cells; Dogs; Down-Regulation; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Mice; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-cbl; Ubiquitin | 2006 |
Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts.
Topics: Bradykinin; Calcium; Calcium Channels; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Econazole; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Nitric Oxide; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 2006 |
Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.
Topics: Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Drug Resistance, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ligands; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Quinazolines; Sequence Deletion; Tyrosine; Ubiquitin | 2007 |
Ganglioside GM(3) is stably associated to tyrosine-phosphorylated ErbB2/EGFR receptor complexes and EGFR monomers, but not to ErbB2.
Topics: Animals; Blotting, Western; Dimerization; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Immunoprecipitation; Mice; Phosphotyrosine; Receptor, ErbB-2 | 2007 |
Protein kinase Cepsilon may act as EGF-inducible scaffold protein for phospholipase Cgamma1.
Topics: Amino Acid Sequence; Animals; Catalysis; Chlorocebus aethiops; Consensus Sequence; COS Cells; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoprecipitation; Molecular Sequence Data; Mutant Proteins; Phospholipase C gamma; Phosphotyrosine; Protein Binding; Protein Kinase C-epsilon; Proto-Oncogene Proteins pp60(c-src); RNA Interference; src Homology Domains | 2007 |
Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.
Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; Gefitinib; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Molecular Sequence Data; Neoplasms; Phosphoproteins; Phosphotyrosine; Proteomics; Quinazolines; Serine Endopeptidases; Signal Transduction; Tandem Mass Spectrometry | 2007 |
Mapping ErbB receptors on breast cancer cell membranes during signal transduction.
Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein Transport; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT5 Transcription Factor; Transfection | 2007 |
Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells.
Topics: Cell Line, Tumor; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Prostatic Neoplasms; Protein-Tyrosine Kinases; PTEN Phosphohydrolase; Receptor, ErbB-3; src-Family Kinases | 2007 |
Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.
Topics: Animals; Cell Line; Chlorocebus aethiops; COS Cells; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; Haplorhini; Humans; Kidney; Mice; Nuclear Proteins; Phosphoinositide Phospholipase C; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Transfection; Ubiquitin-Protein Ligases | 2008 |
Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Fucosyltransferases; Galactoside 2-alpha-L-fucosyltransferase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lewis Blood Group Antigens; Lewis X Antigen; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasms; Phosphotyrosine; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays | 2008 |
Synergistic effect of D-glucose and epidermal growth factor display on dynamic behaviors of human epithelial cells.
Topics: Cell Culture Techniques; Cell Movement; Epidermal Growth Factor; Epithelial Cells; Glucose; Humans; Phosphotyrosine | 2007 |
A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Mutation; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins c-cbl; Ubiquitination | 2008 |
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics.
Topics: Animals; Binding Sites; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; Mass Spectrometry; Mice; Mice, Knockout; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proteomics; Signal Transduction; src Homology Domains; Substrate Specificity | 2008 |
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.
Topics: Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Epithelium, Corneal; Focal Adhesion Protein-Tyrosine Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Models, Biological; Mutant Proteins; Paxillin; Phosphorylation; Phosphoserine; Phosphotyrosine | 2008 |
Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation.
Topics: beta-Cyclodextrins; Cell Line, Tumor; Cholesterol; Dimerization; Endocytosis; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen Peroxide; Keratinocytes; Membrane Microdomains; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Signal Transduction | 2008 |
ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Humans; Molecular Sequence Data; Mutant Proteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Receptor, ErbB-2; Receptors, Somatotropin; Signal Transduction; Ubiquitination | 2008 |
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Female; Fusion Proteins, bcr-abl; Histone Acetyltransferases; Humans; Insulin-Like Growth Factor I; Mice; Nuclear Receptor Coactivator 3; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Binding; Protein Interaction Mapping; Protein-Tyrosine Kinases; Trans-Activators; Transcription Factors | 2008 |
Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks.
Topics: Cell Line, Tumor; Epidermal Growth Factor; Gene Regulatory Networks; Humans; Phosphorylation; Phosphotyrosine; Proteome; Pyrimidines; src-Family Kinases; Time Factors | 2009 |
Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
Topics: Animals; CD59 Antigens; Cell Line; Cross-Linking Reagents; Endocytosis; Enzyme Activation; Epidermal Growth Factor; Humans; Membrane Microdomains; Membrane Proteins; Organelles; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fyn | 2009 |
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Topics: Algorithms; Amino Acid Motifs; Cell Line; Chromatography, Liquid; Epidermal Growth Factor; Epithelial Cells; Humans; Mammary Glands, Human; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Interaction Mapping; Proteome; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2009 |
Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Female; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Interleukin-8; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Phosphotyrosine; Transcription Factor AP-1 | 2010 |
A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Hydrolysis; Mutant Proteins; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Point Mutation; Rats | 2010 |
Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks.
Topics: Blotting, Western; Cell Line, Tumor; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Immunoprecipitation; Isotope Labeling; Phosphotyrosine; Protein Interaction Mapping; Protein-Tyrosine Kinases; Proteome; Proteomics; Reproducibility of Results; Signal Transduction | 2010 |
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.
Topics: Adaptor Proteins, Signal Transducing; Biological Transport; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; Models, Biological; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor Protein-Tyrosine Kinases; Signal Transduction | 2010 |
Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-met; Signal Transduction | 2013 |
The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.
Topics: Animals; Cell Line, Tumor; Cell Movement; Enzyme Activation; Epidermal Growth Factor; Focal Adhesion Protein-Tyrosine Kinases; Gene Silencing; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pseudopodia; RNA, Small Interfering; Wound Healing | 2013 |
Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway.
Topics: Animals; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; G(M2) Ganglioside; G(M3) Ganglioside; Gangliosides; Hepatocyte Growth Factor; Kangai-1 Protein; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Signal Transduction; Up-Regulation | 2013 |
Type II cGMP-dependent protein kinase inhibits ligand‑induced activation of EGFR in gastric cancer cells.
Topics: Betacellulin; Cell Line, Tumor; Cyclic GMP-Dependent Protein Kinase Type II; Enzyme Activation; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Phosphorylation; Phosphotyrosine; Stomach Neoplasms; Transforming Growth Factor alpha | 2014 |
Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Membrane; Dynamin II; Epidermal Growth Factor; ErbB Receptors; Integrin beta1; Ligands; MAP Kinase Signaling System; Mice; NIH 3T3 Cells; Paxillin; Phosphatidylinositol 4,5-Diphosphate; Phosphorylation; Phosphotyrosine; Polymerization; Sirolimus | 2014 |
Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.
Topics: Animals; Bradykinin; Cell Line; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Humans; Hypothalamus; Interferon-gamma; Ligands; Melanocyte-Stimulating Hormones; Mice; Neurons; Neuropeptide Y; Phosphorylation; Phosphoserine; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Cytokine; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thyrotropin-Releasing Hormone; Transcriptional Activation | 2015 |
Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting.
Topics: Biological Assay; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Membrane Proteins; Peptides; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Recombinant Proteins | 2016 |
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.
Topics: Animals; beta Catenin; Brain Neoplasms; Carcinogenesis; cdc25 Phosphatases; Cell Line, Tumor; Cell Nucleus; Epidermal Growth Factor; Glioblastoma; Glycolysis; Humans; Mice; Phosphorylation; Phosphoserine; Phosphotyrosine; Prognosis; Protein Binding; Proto-Oncogene Proteins c-myc; Pyruvate Kinase; src-Family Kinases; Transcriptional Activation | 2016 |
Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy.
Topics: Amino Acid Sequence; Autophagy; Autophagy-Related Protein-1 Homolog; Autophagy-Related Proteins; Cell Membrane; Conserved Sequence; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Phosphorylation; Phosphotyrosine; Protein Transport; src-Family Kinases; Starvation; Stress, Physiological; Vesicular Transport Proteins | 2017 |
Sensitive Approaches for the Assay of the Global Protein Tyrosine Phosphorylation in Complex Samples Using a Mutated SH2 Domain.
Topics: Blotting, Western; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; src Homology Domains; Tyrosine | 2017 |
Tyrphostin AG556 increases the activity of large conductance Ca
Topics: Animals; Basilar Artery; Cell Separation; Epidermal Growth Factor; ErbB Receptors; Genistein; HEK293 Cells; Humans; Indoles; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Male; Myocytes, Smooth Muscle; Phosphorylation; Phosphotyrosine; Protein Subunits; Rats, Sprague-Dawley; Tyrphostins; Vanadates; Vasodilation | 2017 |
Identification of STS-1 as a novel ShcA-binding protein.
Topics: A549 Cells; Amino Acid Sequence; Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression; Humans; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Sequence Alignment; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2017 |
The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking.
Topics: Adaptor Protein Complex Subunits; Amino Acid Motifs; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cell Shape; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Glioma; Humans; Ligands; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Domains; Protein Transport; Proto-Oncogene Proteins c-cbl; rab GTP-Binding Proteins; Shc Signaling Adaptor Proteins; Subcellular Fractions; Transport Vesicles; Ubiquitination | 2017 |
Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase,
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Chromatography, Affinity; Computer Simulation; Consensus Sequence; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Mass Spectrometry; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Array Analysis; Proteome; Proteomics; Reproducibility of Results; RNA-Binding Proteins; src-Family Kinases; Substrate Specificity; Vimentin | 2018 |
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.
Topics: Clathrin-Coated Vesicles; Cross-Linking Reagents; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Ligands; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Multimerization; ras Proteins; Signal Transduction | 2018 |
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
Topics: Amino Acid Sequence; Amino Acids; Animals; Breast Neoplasms; Catalytic Domain; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NIH 3T3 Cells; Peptides; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Receptor, ErbB-2; Signal Transduction; Substrate Specificity | 2020 |
PP2A
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Antibody Specificity; Cross Reactions; Epidermal Growth Factor; HEK293 Cells; Humans; Leucine; Lymphocyte Activation; Methylation; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Peptides; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Processing, Post-Translational; src-Family Kinases; T-Lymphocytes; Vanadates | 2020 |
High-Throughput and Integrated Chemical Proteomic Approach for Profiling Phosphotyrosine Signaling Complexes.
Topics: Chromatography, High Pressure Liquid; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mass Spectrometry; Phosphotyrosine; Protein Array Analysis; Proteome; Proteomics; Signal Transduction | 2020 |
Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling.
Topics: Breast Neoplasms; Cell Line, Tumor; Endocytosis; Endosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Mitogens; Phosphorylation; Phosphotyrosine; Protein Kinase C-delta; Protein Stability; Protein Transport; Protein Tyrosine Phosphatases, Non-Receptor; Protein-Tyrosine Kinases; Proteolysis; rab GTP-Binding Proteins; RNA, Messenger; Time Factors; Ubiquitination | 2021 |
Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.
Topics: Catalysis; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Guanine Nucleotide Exchange Factors; Humans; Occludin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperidines; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proteomics; Pyrimidines; Repressor Proteins; Signal Transduction; src Homology Domains | 2021 |
EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; N-Acetylglucosaminyltransferases; Neoplasms; Phosphorylation; Phosphotyrosine; Pyruvate Kinase; STAT5 Transcription Factor; Tyrosine | 2022 |