phosphothreonine has been researched along with 8-aminoquinoline* in 1 studies
1 other study(ies) available for phosphothreonine and 8-aminoquinoline
| Article | Year |
|---|---|
Phosphothreonine as a catalytic residue in peptide-mediated asymmetric transfer hydrogenations of 8-aminoquinolines.
Phosphothreonine (pThr) was found to constitute a new class of chiral phosphoric acid (CPA) catalyst upon insertion into peptides. To demonstrate the potential of these phosphopeptides as asymmetric catalysts, enantioselective transfer hydrogenations of a previously underexplored substrate class for CPA-catalyzed reductions were carried out. pThr-containing peptides lead to the observation of enantioselectivities of up to 94:6 e.r. with 2-substituted quinolines containing C8-amino functionality. NMR studies indicate that hydrogen-bonding interactions promote strong complexation between substrates and a rigid β-turn catalyst. Topics: Aminoquinolines; Catalytic Domain; Hydrogen; Peptides; Phosphothreonine | 2015 |