phosphoserine has been researched along with phosphothreonine in 597 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (17.42) | 18.7374 |
| 1990's | 233 (39.03) | 18.2507 |
| 2000's | 197 (33.00) | 29.6817 |
| 2010's | 55 (9.21) | 24.3611 |
| 2020's | 8 (1.34) | 2.80 |
| Authors | Studies |
|---|---|
| Glimcher, MJ; Kossiva, D; Lefteriou, B | 1 |
| Radwan, P; Sacharuk, M; Sanecka-Obacz, M | 1 |
| Cozzone, AJ; Manai, M | 2 |
| Gelman, MS; Hadcock, JR; Malbon, CC; Port, JD | 1 |
| Heidecker, G; Kölch, W; Morrison, DK; Rapp, UR | 1 |
| Kataoka, H; Makita, M; Sakiyama, N | 2 |
| Li, P; Roberts, TM; Williams, NG | 1 |
| Afar, DE; Bell, JC; Ben-David, Y; Douville, EM; Howell, BW; Letwin, K; Pawson, T; Tannock, L | 1 |
| Crews, CM; Erikson, RL | 1 |
| Crumpton, MJ; Davies, AA; Jacob, SM; Moss, SE | 1 |
| Kipreos, ET; Wang, JY | 1 |
| Donella-Deana, A; Meyer, HE; Pinna, LA | 1 |
| Diglio, C; Du, YS; Kuo, TH; Tsang, W; Wang, KK | 1 |
| Pillay, TS; Siddle, K | 1 |
| Adams, PD; Parker, PJ | 1 |
| Bird, TA; Saklatvala, J | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Anderson, SR; Malencik, DA; Zhao, ZZ | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Granot, Y; Schrier, RW; Van Putten, V | 1 |
| Cozzone, AJ; Dadssi, M | 1 |
| Singh, TJ | 1 |
| Iwashita, S; Mitsui, K | 1 |
| App, H; Baccarini, M; Rapp, UR; Sabatini, DM; Stanley, ER | 1 |
| Ballou, LM; Luther, H; Thomas, G | 1 |
| Marshall, SH; Muñoz, G | 1 |
| Meggio, F; Perich, JW; Pinna, LA; Reynolds, EC | 1 |
| Byun, SM; Kang, KR; Kang, YS; Kim, CW; Kim, YW | 1 |
| Friedmann, M; Hoover, D; Magnuson, NS; Reeves, R | 1 |
| Iqbal, K; Murthy, LR | 1 |
| Cohen, P; Gómez, N | 1 |
| Ringer, DP | 1 |
| Anderson, NG; Erickson, AK; Ray, LB; Sturgill, TW | 1 |
| Goumard, G; Hayes, DH; Hayes, F | 1 |
| Gerstenfeld, LC; Glimcher, MJ; Gotoh, Y; Landis, WJ; McKee, MD; Nanci, A | 2 |
| Allen, BG; Conigrave, AD; Machan, CL; Roufogalis, BD; Wang, KK; Wright, LC | 1 |
| Crowley, JJ; Raffin, TA | 1 |
| Heilmeyer, LM; Hoffmann-Posorske, E; Meyer, HE | 1 |
| Perich, JW | 1 |
| Fridkin, M; Heffetz, D; Zick, Y | 1 |
| Haas, DW; Hagedorn, CH | 1 |
| Eisenberg, S; Francesconi, SC | 1 |
| Lau, YS | 1 |
| Aguet, M; Ballotti, R; Mao, C; Merlin, G; Metzler, M | 1 |
| Cohen, P; Donella Deana, A; Mac Gowan, CH; Marchiori, F; Meyer, HE; Pinna, LA | 1 |
| Kennedy, MB; Miller, SG; Patton, BL | 1 |
| Colbran, RJ; Soderling, TR | 1 |
| Duronio, V; Jacobs, S | 1 |
| Gerstenfeld, LC; Glimcher, MJ; Gotoh, Y | 1 |
| Arendt, A; Hargrave, PA; Krebs, EG; Litchfield, DW; Lozeman, FJ; Palczewski, K | 1 |
| Ikeda, N; Matsumura, S; Muguruma, M; Yasuda, S | 1 |
| Gerisch, G; Grabatin, B; Lück-Vielmetter, D; Schleicher, M; Wippler, J | 1 |
| Aitken, A; Morrice, N | 1 |
| Carlomagno, L; Huebner, VD; Matthews, HR | 1 |
| Londesborough, J | 1 |
| Bretscher, A; Cooper, JA; Gould, KL; Hunter, T | 1 |
| Ziemiecki, A | 1 |
| Bárány, K; Bárány, M; Csabina, S; Mougios, V | 1 |
| Bergeron, JJ; Kay, DG; Khan, MN; Lai, WH; Posner, BI; Uchihashi, M | 1 |
| Braun, PE; Ulmer, JB | 1 |
| Etheredge, RW; Glimcher, MJ | 1 |
| Niedbalski, JS; Ringer, DP | 1 |
| Destrée, OH; Sluyser, M | 1 |
| Rosen, OM | 1 |
| Fukunaga, K; Funakoshi, T; Kubota, Y; Miyamoto, E; Ohnishi, J; Shoji, S; Ueki, H | 1 |
| Schlossman, SF; Tedder, TF | 1 |
| Colca, JR; McCroskey, MC; Pearson, JD | 1 |
| Johnson, PJ; Kmiecik, TE; Shalloway, D | 1 |
| Eigenbrodt, E; Presek, P; Reinacher, M | 1 |
| Foster, R; Martin, GS; Thorner, J | 1 |
| Boland, D; Goren, HJ; Neufeld, E | 1 |
| Gjika, HB; Levine, L; Van Vunakis, H | 1 |
| Dass, C | 1 |
| Fisher, PA; Smith, DE | 1 |
| Glimcher, MJ; Lefteriou, B | 1 |
| Arendt, A; Caprioli, RM; Hargrave, PA; McDowell, JH; Moore, WT; Palczewski, K | 1 |
| Jones, LR; Lindemann, JP; Simmerman, HK; Wegener, AD | 1 |
| Agnew, WS; Emerick, MC | 1 |
| Hershey, JW | 1 |
| Barua, M; Majumder, GC | 1 |
| Fujita, M; Makita, A; Namiki, M; Ono, M; Sekiya, C; Taniguchi, N | 1 |
| Ray, LB; Sturgill, TW | 1 |
| Gallager, DW; Gallombardo, P; Lloyd, J; Malison, RT; Nestler, EJ; Sweetnam, PM; Tallman, JF | 1 |
| DiSalvo, J; Hegazy, MG; Reimann, EM; Schlender, KK | 1 |
| Meggio, F; Pinna, LA | 1 |
| Hakura, A; Owada, MK; Sobue, K; Tanaka, T | 1 |
| Engström, L; Forsberg, PO; Humble, E; Nettelblad, FA | 1 |
| Corvera, S; Czech, MP; DePaoli-Roach, AA; Roach, PJ | 1 |
| Borysenko, C; Collins, JH; Montibeller, J; Rieker, JP; Swanljung-Collins, H | 1 |
| Kääriäinen, L; Kalkkinen, N; Peränen, J; Takkinen, K | 1 |
| Gurd, JW | 1 |
| Arlinghaus, RB; Maxwell, SA | 1 |
| el-Maghrabi, MR; Glass, DB; Pilkis, SJ | 1 |
| Jones, LR; Liepnieks, J; Simmerman, HK; Wegener, AD | 1 |
| Bockus, BJ; Schaffhausen, B | 1 |
| Cohen, P; Holmes, CF; Major, H; Tonks, NK | 1 |
| Benjamin, WB; Ramakrishna, S | 1 |
| Kahn, CR; Takayama, S; White, MF | 1 |
| Grande, J; Itarte, E; Pérez, M | 1 |
| Hassell, TC; Magnino, PE; Masaracchia, RA | 1 |
| Bárány, K; Bárány, M; Erdödi, F | 1 |
| Colbran, RJ; Keefer, JR; Schworer, CM; Soderling, TR | 1 |
| Gasa, S; Makita, A; Miyazaki, T; Sakurada, K; Uehara, Y | 1 |
| Bárány, K; Bárány, M; Csabina, S | 1 |
| Capoly, JP; Dorée, M; Labbé, JC; Peaucellier, G; Picard, A | 1 |
| Brulfert, J; Gadal, P; Kluge, M; Kruger, I; Le Marechal, P; Queiroz, O; Vidal, J | 1 |
| Bárány, M; Mougios, V | 1 |
| Avila, J; Hernández, MA; Serrano, L; Wandosell, F | 1 |
| Fujita, M; Makita, A; Oikawa, K; Ono, M; Taniguchi, N | 1 |
| Chan, WW; Li, HC | 1 |
| Chang, FH; Chou, MJ; Lee, SC; Shew, JY; Yang, CS | 1 |
| Cotman, CW; Fagg, GE; Foster, AC; Harris, EW; Lanthorn, TH | 1 |
| Clinton, GM; Huang, AS | 1 |
| Busch, H; Satoh, K | 1 |
| Agrawal, D; Agrawal, HC; Randle, CL | 1 |
| Idler, WW; Steinert, PM; Wantz, ML | 1 |
| Fujitaki, JM; Smith, RA; Yang, JC | 1 |
| Congote, LF | 1 |
| Capony, JP; Demaille, JG | 1 |
| Chang, WC; Chou, CK; Lee, ML; Lee, SC | 1 |
| Fehlmann, M; Gazzano, H; Kowalski, A; Van Obberghen, E | 1 |
| Foulkes, JG | 1 |
| Dasgupta, JD; Garbers, DL; Swarup, G | 1 |
| Auricchio, F; Migliaccio, A; Rotondi, A | 1 |
| Martensen, TM | 1 |
| Feunteun, J; Kress, M; Resche-Rigon, M | 1 |
| Echle, B; Scheidtmann, KH; Walter, G | 1 |
| Lowy, D; Papageorge, A; Scolnick, EM | 1 |
| Fiers, W; Fransen, L; van Roy, F | 2 |
| Hunter, T; Papkoff, J | 1 |
| Alitalo, K; Bornstein, P; Keski-Oja, J | 1 |
| Czubak, J; Ostrowski, WS; Wasylewska, E | 1 |
| Anders, DG; Consigli, RA | 1 |
| Boissel, JP; Fagard, R | 1 |
| Brickley-Parsons, D; Glimcher, MJ; Kossiva, D | 1 |
| Kandror, KV; Stepanov, AS | 1 |
| Hiken, JF; Lawrence, JC | 1 |
| Cunningham, BA; Edelman, GM; Hoffman, S; Sorkin, BC | 1 |
| Martin-Pérez, J; Thomas, G | 1 |
| Hathaway, GM; Traugh, JA; Tuazon, PT | 1 |
| Christe, ME; Rao, GJ | 1 |
| Fujitaki, JM; Helander, ER; Smith, LS; Smith, RA; Steiner, AW | 1 |
| Glimcher, MJ; Kossiva, D; Reit, B | 1 |
| Casini, A; Corti, P; Pogliani, L; Sabatini, G | 1 |
| Carroll, RB; Greenspan, DS | 1 |
| Cohen-Solal, L; Glimcher, MJ; Kossiva, D; Lian, JB | 1 |
| Bayley, ST; Branton, PE; Downey, JF; Graham, FL; Lassam, NJ; Mak, S; Yee, SP | 1 |
| Kubo, Y; Natori, S; Segawa, K; Sekimizu, K | 1 |
| Harris, HW; Lux, SE | 1 |
| Jones, CE; Olson, MO | 1 |
| Hisanaga, S; Ishiguro, K; Kishimoto, T; Miyamoto, E; Saito, T; Uchida, T | 1 |
| Fukunaga, R; Nagata, S; Pan, CX; Yonehara, S | 1 |
| Liu, WK; Yang, SD; Yen, SH; Yu, JS | 1 |
| Hakomori, S; Igarashi, Y; Kitamura, K; Zhou, Q | 1 |
| Berti, L; Häring, H; Kellerer, M; Kroder, G; Mosthaf, L; Mushack, J; Seedorf, K; Seffer, E; Tippmer, S | 1 |
| King, SM; Witman, GB | 1 |
| Anderson, MT; Gitler, C; Herzenberg, LA; Staal, FJ; Staal, GE | 1 |
| Daya-Makin, M; Hogg, JC; Lipp, M; Mogentale, TL; Parchomchuk, J; Pelech, SL; Sanghera, JS | 1 |
| DePaoli-Roach, AA; Fiol, CJ; Roach, PJ; Wang, QM | 1 |
| Cutler, RL; Krystal, G; Liu, L; Mui, AL | 1 |
| Damuni, Z; Li, M; Xiong, H | 1 |
| Benjamin, CW; Jones, DA; Linseman, DA | 1 |
| Ali, N; Chua, NH; Halfter, U | 1 |
| Abu-Lawi, KI; Sultzer, BM | 1 |
| Hoffmann, R; Kalbitzer, HR; Reichert, I; Wachs, WO; Zeppezauer, M | 1 |
| Marshall, SH; Muñoz, GE | 1 |
| Kinsey, WH | 1 |
| Giasson, E; Meloche, S | 1 |
| Adam, LP; Gunst, SJ; Pavalko, FM; Walker, TL; Wu, MF | 1 |
| Kumar, R | 1 |
| Pillay, I; Sharma, SV | 1 |
| Fujiki, N; Hamaguchi, M; Miyadai, T; Mutoh, T; Tokuda, A | 1 |
| Lacombe, JM; Mora, N; Pavia, AA | 1 |
| Benarous, R; Bodéus, M; Bougeret, C; Marie-Cardine, A; Ramos-Morales, F | 1 |
| Cuveele, JF; de Witte, PA; Merlevede, WJ; Vandenheede, JR | 1 |
| Maloy, S; Ostrovsky, PC | 1 |
| Biesinger, B; Desrosiers, RC; Friedrich, U; Jun, T; Jung, JU; Lang, SM; Roberts, TM | 1 |
| Parry, R; Sansom, D; Ward, S; Westwick, J; Wilson, A | 1 |
| Frisque, RJ; Swenson, JJ | 1 |
| Lombardini, JB; Props, C | 1 |
| Bosc, DG; Litchfield, DW; Sichler, C; Slominski, E | 1 |
| Bureau, MH; Laschet, JJ | 1 |
| Mikulík, K; Zhulanova, E | 1 |
| Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
| Cleghon, V; Kaplan, DR; Rabin, SJ | 1 |
| Inagami, T; Nakajo, S | 1 |
| Donella-Deana, A; Eisermann, B; Heber, M; Hoffmann-Posorske, E; Hutton, T; Korte, H; Meyer, HE; Perich, JW; Wegner, A; Weigt, C | 1 |
| Greene, LA; Loeb, DM; Volonté, C | 1 |
| Kataoka, H; Makita, M; Nakai, K | 1 |
| Fujimoto, T; McEver, RP | 1 |
| Egelhoff, TT; Lee, RJ; Spudich, JA | 1 |
| Elizarov, SM; Preobrazhensky, AA | 1 |
| Desdouits, F; Girault, JA; Greengard, P; Siciliano, JC | 1 |
| Gu, T; Gu, X; Preuss, U; Yu, RK | 1 |
| Colyer, J; Drago, GA | 1 |
| Carman, GM; Yang, WL | 1 |
| Alberta, JA; Freter, RR; Lam, KK; Stiles, CD | 1 |
| Bernal, RA; Fischer, A; Muganda, PM | 1 |
| Oppenheimer, DI; Volkman, LE | 1 |
| Carnazzi, E; Perich, JW; Seyer, R; Terzi, E; Trifilieff, E | 1 |
| Bhattacharya, G; Boman, BM | 1 |
| Andersen, J; Hansen, TS; Højrup, P; Kristiansen, K; Palm, L; Rahbek-Nielsen, H | 1 |
| Arendt, A; Hargrave, PA | 1 |
| Connor, E; Isaacs, M; Spivak, JL | 1 |
| Huang, JJ; Shiah, SG; Yang, SD; Yu, JS | 1 |
| Cohen, P; Saito, Y; Vandenheede, JR | 1 |
| Capony, JP; Cavadore, JC; Darbon, JM; Derancourt, J; Devault, A; Dorée, M; Fesquet, D; Labbé, JC; Martinez, AM; Morin, N | 1 |
| Dirksen, LB; Krause, DC; Krebes, KA | 1 |
| Bladergroen, BA; Bloomberg, G; Price, NT; Proud, CG; Welsh, GI | 1 |
| Cochran, BJ; Haddox, MK; Worth, LL | 1 |
| Eliasson, E; Halpert, JR; Ingelman-Sundberg, M; Mkrtchian, S | 1 |
| Hann, SR; Lutterbach, B | 2 |
| Bernabéu, C; Langa, C; Lastres, P; Martín-Perez, J | 1 |
| Kennelly, PJ | 1 |
| Horn, MA; Walker, JC | 1 |
| Cohen, PT | 1 |
| Ascoli, M; Hipkin, RW; Quintana, J; Sánchez-Yagüe, J | 1 |
| Cooper, JA; Durden, DL; Rosen, H | 1 |
| Abel, K; Butt, E; Hoppe, J; Hoppe, V; Krieger, M; Palm, D; Walter, U | 1 |
| Gillespie, SK; Wasserman, SA | 1 |
| Hayashi, T; Imura, H; Inoue, G; Kono, S; Kuzuya, H; Nakao, K; Okamoto, M; Yamada, K; Yoshimasa, Y | 1 |
| Ali, Z; Lew, J; Paudel, HK; Wang, JH | 1 |
| Ekman, P; Jäger, O | 1 |
| Garcea, RL; Li, M | 1 |
| Berg, BH | 1 |
| Petersen, TE; Sørensen, ES | 1 |
| Matsumoto, N; Osawa, T; Toyoshima, S | 1 |
| Castana, R; Insirello, L; Leonardi, G; Matera, M | 1 |
| Alberts, AS; Feramisco, JR; Mumby, MC; Shenolikar, S; Thorburn, AM | 1 |
| Botchan, MR; Lentz, MR; Mohr, I; Pak, D | 1 |
| Edes, I; Kranias, EG; Talosi, L | 1 |
| Ahn, NG; Campbell, JS; Graves, LM; Jensen, AL; Krebs, EG; Seger, R | 1 |
| Grose, C; Jackson, W; Yao, Z | 1 |
| Mathews, LS; Vale, WW | 1 |
| Hayashi, T; Imura, H; Inoue, G; Kono, S; Kosaki, A; Kuzuya, H; Nishimura, H; Okamoto, M; Yamada, K; Yoshimasa, Y | 1 |
| Cala, SE; Jones, LR; Kelley, JS; Ulbright, C | 1 |
| Ando, S; Ito, H; Kamijo, M; Kishimoto, T; Kusubata, M; Matsuoka, Y; Ohba, Y; Okumura, E; Tsujimura, K; Yasuda, H | 1 |
| Hargrave, PA; McDowell, JH; Nawrocki, JP | 1 |
| Chen, L; Wu, L; Zhang, ZY | 1 |
| Højrup, P; Petersen, TE; Sørensen, ES | 1 |
| Hata, T; Kitagawa, M; Makino, S; Nishimura, S; Taya, Y; Ueno, Y | 1 |
| Fujitani, K; Ikeda, M; Kambayashi, J; Kawasaki, T; Monden, M; Oiki, E; Okuyama, M; Sakon, M; Shinoki, N; Yano, Y | 1 |
| Blomberg, MA; Chou, TY; Cole, RN; Dong, LY; Greis, KD; Hart, GW; Jiang, MS; Kreppel, LK; Roquemore, EP; Snow, DM | 1 |
| Davis, TN; Friedman, DB; Huang, EY; Sundberg, HA | 1 |
| Adams, GE; Hasan, NM; Parker, PJ | 1 |
| McCormick, F; Porfiri, E | 1 |
| Ohh, M; Takei, F | 1 |
| Gabuzda, D; Goncalves, J; Yang, X | 1 |
| Denu, JM; Dixon, JE; Saper, MA; Yuvaniyama, J | 1 |
| Deyama, Y; Hisada, Y; Matsumoto, A; Okamoto, T; Suzuki, K; Yoshimura, Y | 1 |
| Goldstein, BJ; Li, PM | 1 |
| Deacon, E; Jardine, LJ; Lord, JM; McKendrick, L; Meek, DW; Milne, DM | 1 |
| Dunphy, WG; Kumagai, A | 1 |
| Blessing, RH; Kwiatkowski, W; Maniukiewicz, W | 1 |
| Appella, E; Roller, PP; Sakaguchi, K | 1 |
| Jockusch, BM; Rüdiger, M; Schwienbacher, C | 1 |
| Bennett, V; Hughes, CA; Matsuoka, Y | 1 |
| Apasov, SG; Jelonek, MT; Margulies, DH; Sitkovsky, MV; Smith, PT | 1 |
| Agostinis, PM; Cuveele, JF; de Witte, PA; Merlevede, WJ | 1 |
| Borowski, P; Heiland, M; Kornetzky, L; Laufs, R; Roloff, S; Weber, W | 1 |
| Attwood, P; Ben-Levy, R; Cohen, P; Doza, YN; Leighton, IA; Marshall, CJ; Morrice, N | 1 |
| Foltmann, B; Jensen, AL | 1 |
| Lachowicz, L; Zylińska, L | 1 |
| Esteban, M; Hinnebusch, AG; Lee, SB; Marshak, DR; Mathews, MB; Romano, PR; Taylor, DR | 1 |
| Gu, M; Majerus, PW | 1 |
| Brenner, DG; Ganju, RK; Shipp, MA; Shpektor, RG | 1 |
| Pimentel-Muiños, FX; Seed, B; Ting, AT | 1 |
| Churcher, Y; Moss, SE | 1 |
| Bianchi, R; Eichberg, J; Iyer, S; Rowe-Rendleman, CL | 1 |
| Morrison, DL; Pelech, SL; Sanghera, JS; Stewart, J; Sutherland, C; Walsh, MP | 1 |
| Eriksson, JW; Lönnroth, P; Smith, U; Wesslau, C | 1 |
| Göke, M; Kanai, M; Podolsky, DK; Tsunekawa, S | 1 |
| Ariatti, M; Hawtrey, AO; Van Jaarsveld, PP | 1 |
| Metzger, H; Pribluda, C; Pribluda, VS | 1 |
| Aitken, A; Learmonth, M | 1 |
| Jiang, G; Nepomuceno, L; Sladek, FM; Yang, Q | 1 |
| Brott, B; Chen, DH; Pan, BT; Zhang, Y | 1 |
| Pardo, PS; Passeron, S; Walz, K | 1 |
| Bachvalova, VN; Maksimova, TG; Matveeva, VA; Morozova, OV; Tsekhanovskaya, NA | 1 |
| Koehler, CM; Myers, AM | 1 |
| Lunn, ED; Sytkowski, AJ | 1 |
| Hoffmann, R; Lee, VM; Leight, S; Otvos, L; Varga, I | 1 |
| Ansotegui, IJ; Galron, D; Isakov, N | 1 |
| Fucini, RV; Koretzky, GA; Li, YY; Pessin, JE; Ross, SE; Zhao, H | 1 |
| Olive, D; Parry, RV; Sansom, DM; Ward, SG; Westwick, J | 1 |
| Balaban, N; Goldkorn, T; Matsukuma, K; Shannon, M | 1 |
| Alessi, DR; Andjelković, M; Cron, P; Hemmings, BA; Meier, R | 1 |
| Cantley, LC; Fischer, G; Kirschner, MW; Kuang, J; Lu, KP; Rahfeld, JU; Schutkowski, M; Shen, M; Stukenberg, PT; Xu, J; Yaffe, MB; Zhou, XZ | 1 |
| Divecha, N; Hinchliffe, KA; Irvine, RF | 1 |
| Pawson, T; Scott, JD | 1 |
| Bierman, EL; Bowen, RF; Culala, MM; Deeg, MA; Garver, WS; Oram, JF | 1 |
| Born, JL; Curry, MS; Edwards, BS; Gale, JM; Graf, LH; Robinson, MK; Salazar, F; Southon, EA | 1 |
| Downward, J | 1 |
| Aragón, T; Fernández Santarén, J; Nieto, A; Ortega, J; Ortín, J; Sanz-Ezquerro, JJ; Sierra, T; Smith, GL | 1 |
| Mattiazzi, A; Mundiña-Weilenmann, C; Said, M; Vittone, L | 1 |
| Bernhardt, A; Fischer, G; Lu, KP; Rahfeld, JU; Reimer, U; Schutkowski, M; Shen, M; Zhou, XZ | 1 |
| Cheatham, B; Emkey, R; Inoue, G; Kahn, CR | 1 |
| Sakurada, K; Sasaki, Y; Seto, M | 1 |
| Gooley, AA; Packer, NH; Williams, KL; Yan, JX | 1 |
| Exton, JH; Min, DS | 1 |
| Knebel, B; Koponen, A; Kotzka, J; Kremer, L; Krone, W; Müller-Wieland, D; Munck, M; Njamen, D; Roth, G | 1 |
| Bracho, GE; Tash, JS | 1 |
| DeGnore, JP; Qin, J | 1 |
| Calaghan, SC; Colyer, J; White, E | 1 |
| Gromadzinska, E; Guerini, D; Lachowicz, L; Zylinska, L | 1 |
| Saville, MK; Watson, RJ | 1 |
| Blom, N; Brunak, S; Kreegipuu, A | 1 |
| Chiang, TM | 1 |
| Hemmings, BA; Meier, R; Thelen, M | 1 |
| Lu, KP; Lu, PJ; Shen, M; Zhou, XZ | 1 |
| Hosoi, T; Mahoney, CW; Ohashi, M | 1 |
| Lawen, A; Ng, KT; Zhao, W | 1 |
| Godovac-Zimmermann, J; Müller-Esterl, W; Nyakatura, E; Roos, M; Soskic, V | 1 |
| Childs, G; Li, Z | 1 |
| Alessi, DR; Balendran, A; Casamayor, A; Currie, R; Deak, M; Downes, CP; Gaffney, P; Paterson, A | 1 |
| Naz, RK | 1 |
| Barik, S; Berriman, M; Chakrabarti, D; Del Vecchio, C; Dobson, S; Fairlamb, AH; May, T | 1 |
| Hamano, T; Yamaguchi, M | 1 |
| Cichy, SC; Cohen, P; Guo, S; Rena, G; Unterman, TG | 1 |
| Corbau, R; Nüesch, JP; Rommelaere, J; Salom, N | 1 |
| Nguyen, AN; Shiozaki, K | 1 |
| Duclos, B; Grangeasse, C; Riberty, M; Vaganay, E | 1 |
| Burch, L; Craig, AL; Hupp, TR; Mikutowska, J; Thompson, A; Vojtesek, B | 1 |
| Linnekin, D; Mou, S | 1 |
| Heid, H; Krehan, A; Li, M; Mechler, BM; Neumann, B; Pyerin, W; Strand, D | 1 |
| Cantley, LC; Yaffe, MB | 1 |
| Biden, TJ; Ludowyke, RI; Wilson, JR | 1 |
| Golabek, A; Kaczmarski, A; Kaczmarski, W; Kida, E; Michalewski, MP; Wisniewski, KE | 1 |
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| Aburima, A; Law, R; Magwenzi, S; Naseem, KM; Raslan, Z; Wraith, KS | 1 |
| Boex-Fontvieille, E; Daventure, M; Hodges, M; Jossier, M; Tcherkez, G; Zivy, M | 1 |
| Balog, ER; Faustova, I; Iofik, A; Kivi, R; Kõivomägi, M; Loog, M; Ord, M; Rubin, SM; Valk, E; Venta, R | 1 |
| Chien, PN; Hwang, HS; Jeon, TJ; Jeong, DG; Kim, DS; Kim, JK; Kim, SJ; Ku, B; Park, H; Park, SY; Ryu, SE; Ryu, SY; Wei, CH | 1 |
| Dos Remedios, CG; Foster, DB; Li, Y; Murphy, AM; Sequeira, V; Stienen, GJ; van der Velden, J; Wijnker, PJ | 1 |
| Aerni, HR; Liu, Y; Rinehart, J; Rogulina, S; Steinfeld, JB | 1 |
| Asara, JM; Begley, M; Cantley, L; Gan, W; Gao, D; Ginzberg, M; Gygi, SP; Inuzuka, H; Kim, BM; Kirschner, MW; Lee, TH; Liu, P; Lu, KP; Michowski, W; Pandolfi, PP; Papa, A; Sicinski, P; Singh, A; Toker, A; Tsou, P; Wan, L; Wang, Z; Wei, W; Yuan, M; Zhai, B | 1 |
| Chen, Y; Qian, H; Wu, M; Wu, Y; Yao, X; Zhu, M | 1 |
| Cooper, B | 1 |
| Assmann, SM; Chen, S; Harmon, AC; Ji, W; Silva-Sanchez, C; Song, WY; Zhang, T; Zhu, M | 1 |
| Shang, Y; Xia, Y; Zhang, R; Zhu, J | 1 |
| Ju, S; Kaushal, P; Kwon, Y; Lee, C; Lee, JW | 1 |
| Abularrage, NS; Chambers, KA; Scheck, RA | 1 |
| Bruchas, MR; Brunori, G; Dasgupta, P; Froment, C; Günther, T; Kieffer, BL; Mann, A; Moulédous, L; O'Neill, PR; Schulz, S; Toll, L; Zaveri, NT | 1 |
| Azam, M; Dwivedi, P; Greis, KD; Grimes, HL; Muench, DE; Wagner, M | 1 |
| Burke, TR; Hymel, D; Tsuji, K; Zhao, XZ | 1 |
| Fukushi, Y; Haryuni, RD; Kawasaki, Y; Sakurai, H; Tanaka, T; Watabe, S; Yamaguchi, A; Yokoyama, S; Zhou, Y | 1 |
| Choi, SW; Hoang, QTN; Kim, JI; Kim, MS; Kim, SY; Lee, SJ; Na, YJ; Nguyen, QTC; Sim, SY; Soh, MS; Song, MR | 1 |
| Chen, Y; Dai, S; Liu, Q; Yang, F; Zeng, S | 1 |
| Bernatik, O; Cajanek, L; Hanakova, K; Pejskova, P; Vyslouzil, D; Zdrahal, Z | 1 |
| Beaurepere, R; Boucherit, V; Carreira, A; Duchambon, P; Ehlén, Å; El Marjou, A; Julien, M; Martin, C; Miron, S; Ropars, V; Sessa, G; Theillet, FX; Zinn-Justin, S | 1 |
| Alik, A; Bouguechtouli, C; Ghouil, R; Julien, M; Theillet, FX; Zinn-Justin, S | 1 |
| Basílio, J; Gleitsmann, V; Hochreiter, B; Hoesel, B; Moser, B; Noreen, M; Panhuber, A; Pardo-Garcia, A; Resch, U; Salzmann, M; Schmid, JA | 1 |
| Jackson, RFW; Makwana, MV; Muimo, R; Williamson, MP | 1 |
| Bőhmová, M; Gybeľ, T; Pacherník, J; Radaszkiewicz, KA; Radaszkiewicz, TW; Sladeček, S | 1 |
| Bécsi, B; Erdődi, F; Kónya, Z; Kövér, KE; Lontay, B; Raics, M; Tamás, I; Timári, I | 1 |
22 review(s) available for phosphoserine and phosphothreonine
| Article | Year |
|---|---|
The role of Raf-1 phosphorylation in signal transduction.
Topics: Amino Acid Sequence; Animals; Cell Division; Enzyme Activation; Growth Substances; Humans; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Cell Surface; Serine; Signal Transduction; Substrate Specificity; Threonine; Tyrosine | 1992 |
After insulin binds.
Topics: DNA; Drosophila; ErbB Receptors; Humans; Insulin; Molecular Weight; Oncogenes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Substrate Specificity; Tyrosine | 1987 |
Protein phosphorylation controls translation rates.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis; Proteins; RNA, Messenger; RNA, Transfer, Met | 1989 |
Phosphotyrosyl-protein phosphatases.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Cell Transformation, Viral; Oncogenes; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Retroviridae; Tyrosine | 1983 |
Strategies for nonradioactive methods in the localization of phosphorylated amino acids in proteins.
Topics: Amino Acid Sequence; Amino Acids; Mass Spectrometry; Molecular Sequence Data; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1993 |
Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.
Topics: Animals; Brain; Cell Cycle; DNA, Complementary; Drosophila; Macromolecular Substances; Mammals; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Rabbits; Saccharomyces cerevisiae; Transcription, Genetic | 1993 |
O-linked N-acetylglucosamine: the "yin-yang" of Ser/Thr phosphorylation? Nuclear and cytoplasmic glycosylation.
Topics: Acetylglucosamine; Amino Acid Sequence; Animals; Carbohydrate Conformation; Cell Nucleus; Cytoplasm; Cytoskeletal Proteins; Glycosylation; Humans; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Viral Proteins | 1995 |
New insights into the regulation of ICAM-1 gene expression.
Topics: Animals; Antigens, CD; Binding Sites; Cell Adhesion Molecules; Cycloheximide; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Phosphoserine; Phosphothreonine; Protein Synthesis Inhibitors; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sequence Deletion; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Chemical synthesis and applications of phosphopeptides.
Topics: Amino Acid Sequence; Animals; Antibodies; Antigens; Models, Molecular; Molecular Sequence Data; Organophosphonates; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Structure, Secondary; src Homology Domains; Substrate Specificity; Thermodynamics | 1996 |
[Serine/threonine phosphoprotein phosphatases in brain tissue].
Topics: Animals; Brain; Enzyme Activation; Humans; Nerve Tissue Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine | 1995 |
Signaling through scaffold, anchoring, and adaptor proteins.
Topics: Amino Acid Sequence; Animals; Ligands; Phospholipids; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Signal Transduction; src Homology Domains | 1997 |
Protein phosphorylation: technologies for the identification of phosphoamino acids.
Topics: Animals; Humans; Phosphoamino Acids; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1998 |
Phytochromes as light-modulated protein kinases.
Topics: Bacterial Proteins; Light; Models, Biological; Phosphorylation; Phosphoserine; Phosphothreonine; Phytochrome; Plant Physiological Phenomena; Protein Kinases; Signal Transduction | 2000 |
Phosphoserine/threonine-binding domains.
Topics: Animals; Binding Sites; Humans; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Structure, Tertiary | 2001 |
PhosphoSerine/threonine binding domains: you can't pSERious?
Topics: Animals; Humans; Models, Molecular; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Structure, Tertiary; Signal Transduction | 2001 |
Pinning down cell signaling, cancer and Alzheimer's disease.
Topics: Alzheimer Disease; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Humans; Models, Biological; Models, Molecular; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Proline-Directed Protein Kinases; Protein Structure, Tertiary; Signal Transduction | 2004 |
Identifying protein kinase substrates: hunting for the organ-grinder's monkeys.
Topics: Animals; Antibodies; Blotting, Western; Chromatography, Affinity; Humans; Mass Spectrometry; Models, Chemical; Peptide Library; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Proteomics; Substrate Specificity | 2004 |
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Topics: Alzheimer Disease; Cell Proliferation; Humans; Isomerism; Neoplasms; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Signal Transduction | 2005 |
14-3-3 proteins: a number of functions for a numbered protein.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Amino Acid Sequence; Animals; Consensus Sequence; Humans; Molecular Sequence Data; Multiprotein Complexes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Processing, Post-Translational; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity | 2005 |
The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability.
Topics: Animals; Cyclin-Dependent Kinase Inhibitor p21; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding | 2006 |
The effect of post-translational and process-induced modifications on the multistage gas-phase fragmentation reactions of protonated peptides.
Topics: Cysteine; Gases; Mass Spectrometry; Methionine; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protons | 2009 |
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.
Topics: Cell Cycle; DNA Damage; DNA Repair; Humans; Models, Molecular; Phosphoserine; Phosphothreonine; Protein Binding; Protein Structure, Tertiary; Proteins | 2013 |
575 other study(ies) available for phosphoserine and phosphothreonine
| Article | Year |
|---|---|
Identification of O-phosphoserine, O-phosphothreonine and gamma-carboxyglutamic acid in the non-collagenous proteins of bovine cementum; comparison with dentin, enamel and bone.
Topics: 1-Carboxyglutamic Acid; Amino Acids; Animals; Cattle; Dental Cementum; Dental Enamel; Dentin; Fetus; Glutamates; Male; Phosphoserine; Phosphothreonine; Serine; Threonine | 1979 |
[A simple method for detecting phosphoserine and phosphothreonine in proteins (author's transl)].
Topics: Animals; Brain; Chick Embryo; Electrophoresis, Paper; Histones; Liver; Phosphoserine; Phosphothreonine; Protein Hydrolysates; Ribosomal Proteins; Ribosomes; Serine; Threonine | 1979 |
Analysis of the protein-kinase activity of Escherichia coli cells.
Topics: Bacterial Proteins; Escherichia coli; Molecular Weight; Mutation; Phosphoproteins; Phosphoserine; Phosphothreonine; Protein Kinases; Ribosomal Proteins | 1979 |
Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.
Topics: Animals; Cell Line; Cricetinae; GTP-Binding Proteins; Insulin; Iodine Radioisotopes; Isoproterenol; Kinetics; Male; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Adrenergic, beta; Tyrosine; Vas Deferens | 1992 |
Occurrence of free O-phosphoserine and O-phosphothreonine in porcine liver.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Liver; Phosphoserine; Phosphothreonine; Swine | 1990 |
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.
Topics: Animals; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Moths; Oncogene Protein pp60(v-src); Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Tyrosine | 1992 |
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Compartmentation; Cell Membrane; Cloning, Molecular; Cytoplasm; DNA; Gene Expression; In Vitro Techniques; Mice; Molecular Sequence Data; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; RNA, Messenger; Sequence Alignment; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1992 |
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Fungal Proteins; Genes; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Recombinant Proteins; Sequence Alignment; Tyrosine | 1992 |
A growth-dependent post-translational modification of annexin VI.
Topics: 3T3 Cells; Animals; Annexin A6; Cell Line; Growth Substances; Humans; Lymphocytes; Mice; Mitotic Index; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis | 1992 |
Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Cycle; Chromatography, Affinity; DNA; Genes, abl; Mice; Molecular Sequence Data; Mutagenesis; Phosphorylation; Phosphoserine; Phosphothreonine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Structure-Activity Relationship | 1992 |
The use of phosphopeptides to distinguish between protein phosphatase and acid/alkaline phosphatase activities: opposite specificity toward phosphoseryl/phosphothreonyl substrates.
Topics: Acid Phosphatase; Alkaline Phosphatase; Amino Acid Sequence; Molecular Sequence Data; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Substrate Specificity | 1991 |
Hormone-induced phosphorylation of the plasma membrane calcium pump in cultured aortic endothelial cells.
Topics: Animals; Aorta, Thoracic; Biological Transport, Active; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Enzyme Activation; Hormones; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thionucleotides | 1991 |
Insulin-stimulated serine/threonine phosphorylation of the insulin receptor: paucity of threonine 1348 phosphorylation in vitro indicates the involvement of more than one serine/threonine kinase in vivo.
Topics: Animals; Cell Line; Electrophoresis, Gel, Two-Dimensional; Insulin; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Threonine; Transfection | 1991 |
TPA-induced activation of MAP kinase.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Molecular Sequence Data; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1991 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Determination of dityrosine, phosphotyrosine, phosphothreonine, and phosphoserine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Microchemistry; p-Dimethylaminoazobenzene; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Serine; Threonine; Tyrosine | 1990 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Vasopressin dependent tyrosine phosphorylation of a 38 kDa protein in human platelets.
Topics: Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Blood Platelets; Blotting, Western; Colforsin; Dose-Response Relationship, Drug; Electrophoresis; Humans; In Vitro Techniques; Phorbol Esters; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Vasopressin; Time Factors; Tyrosine | 1990 |
Occurrence of protein phosphorylation in various bacterial species.
Topics: Adenosine Triphosphate; Arthrobacter; Bacillus; Bacillus megaterium; Bacteria; Bacterial Proteins; Cyclic AMP; Cyclic GMP; Escherichia coli; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Pseudomonas; Tyrosine | 1990 |
Activation of a manganese-dependent membrane protein kinase by serine and tyrosine phosphorylation.
Topics: Animals; Casein Kinases; Enzyme Activation; In Vitro Techniques; Manganese; Myelin Basic Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin | 1990 |
[Phosphoamino acid analysis by 2-dimensional electrophoresis].
Topics: Electrophoresis, Gel, Two-Dimensional; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1990 |
Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.
Topics: Amino Acid Sequence; Animals; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Temperature; Tyrosine | 1990 |
MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways.
Topics: Adipose Tissue; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Reactivators; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Xenopus | 1991 |
An alternative method for a fast separation of phosphotyrosine.
Topics: Adenosine Triphosphate; Animals; Chromatography, Thin Layer; Cytidine Monophosphate; Humans; Liver; Lymphocytes; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine; Uridine Monophosphate | 1990 |
Phosphotyrosine as a specificity determinant for casein kinase-2, a growth related Ser/Thr-specific protein kinase.
Topics: Amino Acid Sequence; Animals; Casein Kinases; Cell Division; Cytosol; Kinetics; Liver; Molecular Sequence Data; Oligopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Substrate Specificity; Tyrosine | 1991 |
Elongation factor-2 in chick embryo is phosphorylated on tyrosine as well as serine and threonine.
Topics: Age Factors; Animals; Chick Embryo; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Tyrosine | 1991 |
Recombinant human pim-1 protein exhibits serine/threonine kinase activity.
Topics: Cloning, Molecular; DNA; Escherichia coli; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Recombinant Proteins; Substrate Specificity; Tyrosine | 1991 |
Distribution and contents of free O-phosphoamino acids in animal tissues.
Topics: Animals; Brain Chemistry; Chickens; Chromatography, Gas; Fishes; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Myocardium; Organ Specificity; Phosphoserine; Phosphothreonine; Phosphotyrosine; Species Specificity; Swine; Tyrosine | 1991 |
Measurement of picomoles of phosphoamino acids by high-performance liquid chromatography.
Topics: Amino Acids; Caseins; Chromatography, High Pressure Liquid; Organophosphorus Compounds; Phosphoserine; Phosphothreonine; Phosphotyrosine; Reproducibility of Results; Serum Albumin, Bovine; Tyrosine | 1991 |
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Antigens, CD; Enzyme Activation; Histocompatibility Antigens; In Vitro Techniques; Leukocyte Common Antigens; Nerve Growth Factors; Neurons; Pheochromocytoma; Phosphoprotein Phosphatases; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Rats; Receptor, trkA; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
Separation of phosphotyrosine, phosphoserine, and phosphothreonine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrolysis; Indicators and Reagents; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1991 |
Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Autoradiography; Buffers; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Indicators and Reagents; Kinetics; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
Monovalent cation-dependent reversible phosphorylation of ribosomal protein S8 in growth arrested Tetrahymena: kinetics of formation, phosphoamino acids, and phosphopeptides of mono-, and diphosphorylated derivatives of protein S8.
Topics: Amino Acid Sequence; Animals; Cations, Monovalent; Kinetics; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Ribosomal Proteins; Tetrahymena thermophila | 1991 |
Effects of fixation and demineralization on the retention of bone phosphoprotein and other matrix components as evaluated by biochemical analyses and quantitative immunocytochemistry.
Topics: Amino Acids; Animals; Bone and Bones; Bone Matrix; Chick Embryo; Collagen; Glutaral; Immunohistochemistry; Phosphoproteins; Phosphoserine; Phosphothreonine; Tissue Fixation | 1991 |
Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium-Transporting ATPases; Calmodulin; Calpain; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rats; Trypsin | 1991 |
Tumor necrosis factor-induced protein phosphorylation in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; In Vitro Techniques; Isoelectric Point; Isoquinolines; Molecular Weight; Neutrophils; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; Sulfonamides; Tumor Necrosis Factor-alpha | 1991 |
Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cysteine; Hydrolysis; Indicators and Reagents; Macromolecular Substances; Molecular Sequence Data; Myocardium; Oligopeptides; Phosphopeptides; Phosphoproteins; Phosphorylase Kinase; Phosphoserine; Phosphothreonine; Troponin; Troponin I | 1991 |
Synthesis of O-phosphoserine- and O-phosphothreonine-containing peptides.
Topics: Amino Acid Sequence; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphoserine; Phosphothreonine | 1991 |
Generation and use of antibodies to phosphothreonine.
Topics: Animals; Antibodies; Antibody Specificity; Cell Line; Chromatography, Affinity; Immunoblotting; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Rabbits | 1991 |
Casein kinase I phosphorylates the 25-kDa mRNA cap-binding protein.
Topics: Animals; Casein Kinases; Eukaryotic Initiation Factor-4E; Humans; In Vitro Techniques; Peptide Initiation Factors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rabbits; RNA Caps | 1991 |
The multifunctional protein OBF1 is phosphorylated at serine and threonine residues in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; DNA-Binding Proteins; DNA, Fungal; Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Gene Expression; Immunoblotting; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Plasmids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Trypsin | 1991 |
Characteristics of Ca2+/calmodulin- and Ca2+/phosphatidylserine-stimulated phosphoproteins in rat striatum.
Topics: Animals; Calcium; Calmodulin; Chemical Phenomena; Chemistry, Physical; Corpus Striatum; Egtazic Acid; Male; Octoxynol; Phosphatidylserines; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1990 |
Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Humans; In Vitro Techniques; Interferon-gamma; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinases; Receptors, Immunologic; Receptors, Interferon; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A.
Topics: Alanine; Amino Acid Sequence; Angiotensin II; Animals; Arginine; Binding Sites; Molecular Sequence Data; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Protein Phosphatase 2; Substrate Specificity; Valine | 1990 |
Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Enzyme Activation; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rabbits; Rats; Threonine; Trypsin | 1990 |
Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Egtazic Acid; Enzyme Activation; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rats; Serine; Threonine | 1990 |
The effect of protein kinase-C inhibition on insulin receptor phosphorylation.
Topics: Alkaloids; Cell Line; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Insulin; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate; Trypsin | 1990 |
Developmental appearance and ultrastructural immunolocalization of a major 66 kDa phosphoprotein in embryonic and post-natal chicken bone.
Topics: Aging; Animals; Blotting, Western; Bone and Bones; Bone Development; Calcification, Physiologic; Chick Embryo; Chickens; Immunohistochemistry; Microscopy, Electron; Phosphoproteins; Phosphoserine; Phosphothreonine; Tibia | 1990 |
Identification and characterization of the major chicken bone phosphoprotein. Analysis of its synthesis by cultured embryonic chick osteoblasts.
Topics: Amino Acid Sequence; Animals; Bone and Bones; Cells, Cultured; Chick Embryo; Glycosylation; Kinetics; Leucine; Molecular Sequence Data; Molecular Weight; Osteoblasts; Peptide Fragments; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Tritium; Trypsin | 1990 |
Synthetic phosphopeptides are substrates for casein kinase II.
Topics: Amino Acid Sequence; Casein Kinases; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Substrate Specificity | 1990 |
Protein kinase C phosphorylates both the light chains and the head portion of the heavy chains of brain myosin.
Topics: Animals; Brain; Cattle; In Vitro Techniques; Molecular Weight; Myosins; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rats | 1990 |
Replacement of threonine residues by serine and alanine in a phosphorylatable heavy chain fragment of Dictyostelium myosin II.
Topics: Alanine; Amino Acid Sequence; Dictyostelium; DNA Mutational Analysis; Molecular Sequence Data; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Restriction Mapping; Structure-Activity Relationship; Substrate Specificity | 1990 |
A simple and rapid method of quantitative analysis of phosphoamino acids by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1985 |
Rapid separation of phosphoamino acids including the phosphohistidines by isocratic high-performance liquid chromatography of the orthophthalaldehyde derivatives.
Topics: Aldehydes; Amino Acids; Arginine; Buffers; Chromatography, High Pressure Liquid; Histidine; o-Phthalaldehyde; Organophosphorus Compounds; Phosphoserine; Phosphothreonine; Phosphotyrosine; Temperature; Tyrosine | 1985 |
Phosphorylation of proteins in Clostridium thermohydrosulfuricum.
Topics: Bacterial Proteins; Calmodulin; Cell-Free System; Clostridium; Hexosephosphates; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyamines; Subcellular Fractions; Tyrosine | 1986 |
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.
Topics: Animals; Carrier Proteins; Cell Line; Cytoskeletal Proteins; Fluorescent Antibody Technique; Humans; Isoelectric Point; Microfilament Proteins; Microvilli; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Tissue Distribution; Tyrosine | 1986 |
Characterization of the monomeric and complex-associated forms of the gag-onc fusion proteins of three isolates of feline sarcoma virus: phosphorylation, kinase activity, acylation, and kinetics of complex formation.
Topics: Acylation; Animals; Cats; Cells, Cultured; Fibroblasts; Gene Products, gag; Kinetics; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Retroviridae; Retroviridae Proteins; Sarcoma Viruses, Feline; Tyrosine | 1986 |
Characterization of the phosphorylatable myosin light chain in rat uterus.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Female; Isoelectric Point; Molecular Weight; Myosins; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Tyrosine; Uterus | 1986 |
Epidermal growth factor receptor kinase translocation and activation in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Golgi Apparatus; Kinetics; Liver; Male; Microscopy, Electron; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Tyrosine | 1986 |
In vivo phosphorylation of myelin basic proteins: single and double isotope incorporation in developmentally related myelin fractions.
Topics: Animals; Brain; Mice; Molecular Weight; Myelin Basic Protein; Myelin Sheath; Phosphorylation; Phosphoserine; Phosphothreonine; Solubility | 1986 |
Resolution and identification of O-phosphoserine, O-phosphothreonine, O-phosphotyrosine, and gamma-carboxyglutamic acid as their fluorescent o-phthalaldehyde derivatives by high performance liquid chromatography.
Topics: 1-Carboxyglutamic Acid; Animals; Chromatography, High Pressure Liquid; Fluorescent Dyes; o-Phthalaldehyde; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1986 |
Separation and quantitative analysis of O-linked phosphoamino acids by isocratic high-performance liquid chromatography of the 9-fluorenylmethyl chloroformate derivatives.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Fluorenes; Ion Exchange Resins; Organophosphorus Compounds; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1986 |
Histone phosphorylation in explants of mouse mammary glands and tumors.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Histones; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1986 |
Phosphorylation sites of bovine brain myelin basic protein phosphorylated with Ca2+-calmodulin-dependent protein kinase from rat brain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Brain Chemistry; Calcium; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Cyclic AMP; Molecular Sequence Data; Myelin Basic Protein; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinases; Rats; Trypsin | 1987 |
Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes.
Topics: Antibodies; Antigens; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Electrophoresis, Polyacrylamide Gel; Humans; Immunosorbent Techniques; Kinetics; Leukemia, Lymphoid; Molecular Weight; Peptide Fragments; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Determination of [32P]phosphoamino acids in protein hydrolysates by isocratic anion-exchange high-performance liquid chromatography.
Topics: Buffers; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Serine; Spectrophotometry, Ultraviolet; Threonine; Tyrosine | 1988 |
Regulation by the autophosphorylation site in overexpressed pp60c-src.
Topics: Animals; Mice; Mutation; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Structure-Activity Relationship; Tyrosine; Vanadium | 1988 |
Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Immunosorbent Techniques; Kinetics; Oncogene Protein pp60(v-src); Phosphoenolpyruvate; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvate Kinase; Retroviridae Proteins; Tyrosine | 1988 |
Nucleotidylation, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria.
Topics: Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Glutamate-Ammonia Ligase; Hydrolysis; Molecular Weight; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Radioisotope Dilution Technique; Salmonella typhimurium; Species Specificity; Tyrosine | 1989 |
Thin-layer chromatography can resolve phosphotyrosine, phosphoserine, and phosphothreonine in a protein hydrolyzate.
Topics: Animals; Autoradiography; Chromatography, Thin Layer; Humans; Hydrolysis; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1989 |
Antibodies and radioimmunoassays for phosphoserine, phosphothreonine and phosphotyrosine. Serologic specificities and levels of the phosphoamino acids in cytoplasmic fractions of rat tissues.
Topics: Animals; Antibodies; Antibody Specificity; Chromatography, Ion Exchange; Cytoplasm; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred F344; Serine; Serum Albumin, Bovine; Threonine; Tyrosine | 1989 |
Characterization of phosphorylated amino acids by fast-atom bombardment mass spectrometry.
Topics: Phosphoserine; Phosphothreonine; Phosphotyrosine; Spectrometry, Mass, Fast Atom Bombardment; Tyrosine | 1989 |
Interconversion of Drosophila nuclear lamin isoforms during oogenesis, early embryogenesis, and upon entry of cultured cells into mitosis.
Topics: Animals; Cyanogen Bromide; Drosophila melanogaster; Electrophoresis, Polyacrylamide Gel; Interphase; Lamins; Mitosis; Nuclear Envelope; Nuclear Proteins; Oocytes; Oogenesis; Peptide Fragments; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine | 1989 |
Soluble glycosylated phosphoproteins of cementum.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dental Cementum; Electrophoresis, Polyacrylamide Gel; Glycosylation; Hydroxyproline; Phosphoproteins; Phosphoserine; Phosphothreonine | 1989 |
Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Affinity; Mass Spectrometry; Phosphopeptides; Phosphoserine; Phosphothreonine; Serine; Threonine | 1989 |
Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Calcium-Binding Proteins; Female; Guinea Pigs; Heart Ventricles; Isoproterenol; Macromolecular Substances; Male; Molecular Sequence Data; Myocardium; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Receptors, Adrenergic, beta; Serine; Threonine; Trypsin | 1989 |
Identification of phosphorylation sites for adenosine 3',5'-cyclic phosphate dependent protein kinase on the voltage-sensitive sodium channel from Electrophorus electricus.
Topics: Amino Acid Sequence; Amino Acids; Animals; Brain; Electrophorus; Electrophysiology; Kinetics; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Kinase C; Protein Kinases; Rabbits; Rats; Sequence Homology, Nucleic Acid; Sodium Channels | 1989 |
Enzymic characteristics of ecto-phosphoprotein phosphatase in goat epididymal intact spermatozoa.
Topics: Animals; Cations, Divalent; Epididymis; Goats; Kinetics; Male; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Polyamines; Spermatozoa; Substrate Specificity | 1987 |
Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.
Topics: Amino Acids; Carcinoma, Hepatocellular; Cyclic AMP; Glucuronidase; Humans; Immunodiffusion; Kinetics; Liver; Liver Neoplasms; Molecular Weight; Peptide Fragments; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Trypsin | 1988 |
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Centrifugation, Density Gradient; Chromatography; Cytosol; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Insulin; Kinetics; Mice; Microtubule-Associated Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Kinases; Serine; Substrate Specificity; Threonine | 1988 |
Phosphorylation of the GABAa/benzodiazepine receptor alpha subunit by a receptor-associated protein kinase.
Topics: Animals; Brain; Brain Chemistry; Cell Membrane; Cerebellum; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Isoelectric Point; Male; Molecular Weight; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Modulation of glycogen synthase kinase activity of skeletal and smooth muscle casein kinase I by spermine.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cyanogen Bromide; Cyclic AMP; Glycogen Synthase; Glycogen Synthase Kinases; Muscle, Smooth, Vascular; Muscles; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rabbits; Spermine; Trypsin | 1988 |
Phosphorylation of phosvitin by casein kinase-2 provides the evidence that phosphoserines can replace carboxylic amino acids as specificity determinants.
Topics: Amino Acids; Aspartic Acid; Casein Kinases; Egg Proteins; Glutamates; Glutamic Acid; Phosphorylation; Phosphoserine; Phosphothreonine; Phosvitin; Protein Kinases; Serine; Substrate Specificity | 1988 |
Linear relationship between diphosphorylation of 20 kDa light chain of gizzard myosin and the actin-activated myosin ATPase activity.
Topics: Actins; Actomyosin; Adenosine Triphosphatases; Animals; Calmodulin; Chickens; Gizzard, Avian; Kinetics; Myosin-Light-Chain Kinase; Myosins; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases | 1985 |
Aspects on the phosphorylation of muscle phosphofructokinase by protein kinase C--inhibition by phosphofructokinase stabilisers.
Topics: Adenosine Monophosphate; Animals; Fructosediphosphates; Fructosephosphates; Kinetics; Muscles; Phosphofructokinase-1; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rabbits; Rats | 1986 |
Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.
Topics: Adenosine Triphosphate; Adipose Tissue; Animals; Casein Kinases; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Immunoassay; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor II; Liver Neoplasms, Experimental; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rats; Receptor, Insulin; Receptors, Somatomedin; Tumor Cells, Cultured | 1988 |
Phosphorylation of brush border myosin at threonine on its 20 kDa light chains by a calmodulin-independent kinase activates its ATPase.
Topics: Actins; Adenosine Triphosphatases; Animals; Calcium; Calmodulin; Chickens; Egtazic Acid; Enzyme Activation; Intestines; Microvilli; Myosins; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Threonine; Trypsin | 1988 |
Semliki Forest virus-specific non-structural protein nsP3 is a phosphoprotein.
Topics: Antibody Specificity; Capsid; Cell Compartmentation; DNA-Directed RNA Polymerases; DNA, Recombinant; Immunologic Techniques; Phosphoproteins; Phosphoserine; Phosphothreonine; Recombinant Fusion Proteins; Semliki forest virus; Viral Core Proteins; Viral Nonstructural Proteins | 1988 |
Phosphorylation of the postsynaptic density glycoprotein gp180 by Ca2+/calmodulin-dependent protein kinase.
Topics: Animals; Calcium; Calmodulin; Cattle; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Membrane Glycoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Synapses | 1985 |
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos.
Topics: Antigen-Antibody Complex; Cell Transformation, Viral; Cyclic AMP; Cyclic GMP; Diphosphates; Gene Products, gag; Moloney murine sarcoma virus; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Quercetin; Retroviridae Proteins; Sarcoma Viruses, Murine; Temperature | 1985 |
Synthetic peptides corresponding to the site phosphorylated in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates of cyclic nucleotide-dependent protein kinases.
Topics: Amino Acid Sequence; Animals; Cyclic AMP; Cyclic GMP; Kinetics; Liver; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Rats; Substrate Specificity | 1986 |
Proteolytic cleavage of phospholamban purified from canine cardiac sarcoplasmic reticulum vesicles. Generation of a low resolution model of phospholamban structure.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Chemical Phenomena; Chemistry; Cyclic AMP; Dogs; Macromolecular Substances; Models, Chemical; Myocardium; Peptide Fragments; Peptide Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Sarcoplasmic Reticulum | 1986 |
Localization of the phosphorylations of polyomavirus large T antigen.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cells, Cultured; Mice; Molecular Weight; Mutation; Oncogene Proteins, Viral; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Polyomavirus; Protein Kinases | 1987 |
Analysis of the in vivo phosphorylation state of protein phosphatase inhibitor-2 from rabbit skeletal muscle by fast-atom bombardment mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Epinephrine; Insulin; Mass Spectrometry; Muscle Proteins; Oligopeptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Propranolol; Protein Phosphatase 1; Proteins; Rabbits | 1987 |
Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue.
Topics: Adipose Tissue; Animals; ATP Citrate (pro-S)-Lyase; Chromatography; Chromatography, High Pressure Liquid; Cycloheximide; Cytosol; Insulin; Kinetics; Male; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Trypsin | 1988 |
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Chromatography, Affinity; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Phosphoserine; Phosphothreonine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1988 |
Phosphorylation of hepatic insulin receptor by casein kinase 2.
Topics: Adenosine Triphosphate; Animals; Casein Kinases; Cell Membrane; Guanosine Triphosphate; Heparin; Liver; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin | 1988 |
Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C.
Topics: Animals; Calcium; Diglycerides; Enzyme Activation; In Vitro Techniques; Kinetics; Mice; Myosin-Light-Chain Kinase; Myosins; Oligopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinases | 1988 |
Myosin light chain isoforms and their phosphorylation in arterial smooth muscle.
Topics: Animals; Carotid Arteries; Electrophoresis, Polyacrylamide Gel; Immunoenzyme Techniques; Isoelectric Point; Molecular Weight; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Potassium; Swine | 1987 |
Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Brain; Calcium; Calmodulin; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Electrophoresis, Polyacrylamide Gel; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Rats | 1988 |
Protein phosphorylation of lysosomal arylsulfatase B in normal and leukemic leukocytes.
Topics: Chondro-4-Sulfatase; Humans; Leukemia, Myeloid; Leukocytes; Lysosomes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Sulfatases | 1986 |
Comparison of myosin light chain phosphorylation in uterine and arterial smooth muscles.
Topics: Animals; Carotid Arteries; Electrophoresis, Polyacrylamide Gel; Female; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Muscles; Myosins; Phosphorylation; Phosphoserine; Phosphothreonine; Rana pipiens; Rats; Rats, Inbred Strains; Swine; Uterine Contraction; Uterus | 1987 |
Changes in the activity of the maturation-promoting factor during meiotic maturation and following activation of amphibian and starfish oocytes: their correlations with protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Calcium; Growth Substances; Guanosine Triphosphate; Maturation-Promoting Factor; Meiosis; Oocytes; Parthenogenesis; Phosphoproteins; Phosphoserine; Phosphothreonine; Starfish; Xenopus laevis | 1986 |
Phosphorylation-dephosphorylation process as a probable mechanism for the diurnal regulatory changes of phosphoenolpyruvate carboxylase in CAM plants.
Topics: Acid Phosphatase; Autoradiography; Carboxy-Lyases; Chemical Phenomena; Chemistry, Physical; Circadian Rhythm; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucose-6-Phosphate; Glucosephosphates; Malates; Phosphoenolpyruvate Carboxylase; Phosphorylation; Phosphoserine; Phosphothreonine; Plants | 1986 |
Isoforms of the phosphorylatable myosin light chain in arterial smooth muscle.
Topics: Animals; Muscle, Smooth, Vascular; Myosins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Swine | 1986 |
Phosphorylation of tubulin by a calmodulin-dependent protein kinase.
Topics: Animals; Brain; Calmodulin; Chemical Phenomena; Chemical Precipitation; Chemistry, Physical; Chromatography; Cytosol; Kinetics; Macromolecular Substances; Microtubule-Associated Proteins; Microtubules; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Kinases; Substrate Specificity; Swine; Tubulin | 1986 |
Protein phosphorylation of beta-glucuronidase in human lung cancer--identification of serine- and threonine-phosphates.
Topics: Adenocarcinoma; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Glucuronidase; Humans; Hydrolysis; Immunodiffusion; Liver; Lung; Lung Neoplasms; Phosphorylation; Phosphoserine; Phosphothreonine; Serine; Threonine | 1985 |
Activation of brain calcineurin towards proteins containing Thr(P) and Ser(P) by Ca2+, calmodulin, Mg2+ and transition metal ions.
Topics: Animals; Brain; Calcium; Calmodulin; Calmodulin-Binding Proteins; Caseins; Cattle; Cobalt; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Nickel; Phosphoprotein Phosphatases; Phosphoproteins; Phosphoserine; Phosphothreonine; Serine; Threonine | 1984 |
Change of hepatitis B virions (Dane particles) phosphorylation pattern by human hepatoma cell particulate fraction.
Topics: Carcinoma, Hepatocellular; Cell Line; Fibroblasts; Hepatitis B virus; Humans; Liver Neoplasms; Lymphocytes; Peptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Subcellular Fractions; Viral Proteins; Virion | 1984 |
Structure--activity relationships of L-glutamate receptor ligands: role of the omega-acidic terminal.
Topics: Aminobutyrates; Animals; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Phosphoserine; Phosphothreonine; Rats; Receptors, Cell Surface; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1982 |
Distribution of phosphoserine, phosphothreonine and phosphotyrosine in proteins of vesicular stomatitis virus.
Topics: Animals; Cells, Cultured; Cricetinae; Kidney; Mesocricetus; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Tyrosine; Vesicular stomatitis Indiana virus; Viral Proteins | 1981 |
Silver staining of phosphoserine and phosphothreonine in nucleolar and other phosphoproteins.
Topics: Animals; Cell Nucleolus; Histocytochemistry; Liver Neoplasms, Experimental; Phosphoserine; Phosphothreonine; Rats; Serine; Silver; Staining and Labeling; Threonine | 1981 |
In vivo phosphorylation of two myelin basic proteins of developing rabbit brain.
Topics: Amino Acids; Animals; Brain; Immunodiffusion; Molecular Weight; Myelin Basic Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits | 1981 |
O-phosphoserine content of intermediate filament subunits.
Topics: Animals; Cattle; Cricetinae; Cricetulus; Cytoskeleton; Decapodiformes; Desmin; Female; Keratins; Mesocricetus; Methods; Methylamines; Mice; Mice, Inbred BALB C; Muscle Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Serine; Tissue Distribution; Turkeys; Vimentin | 1982 |
Separation of phosphohydroxyamino acids by high-performance liquid chromatography.
Topics: Animals; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cyclic AMP; Hydrolysis; Myelin Basic Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Serine; Threonine; Tyrosine | 1982 |
Two-dimensional separation of phosphoamino acids from nucleoside monophosphates.
Topics: Adenosine Monophosphate; Chromatography, Thin Layer; Cytidine Monophosphate; Electrophoresis; Escherichia coli; Guanosine Monophosphate; Nucleotides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Thymidine Monophosphate; Tyrosine; Uracil Nucleotides; Uridine Monophosphate | 1982 |
Dansylation and high-performance liquid chromatographic separation of phosphoserine, phosphothreonine and phosphotyrosine from 32P-labeled protein hydrolyzates.
Topics: Animals; Binding Sites; Chromatography, High Pressure Liquid; Dansyl Compounds; Hydrolysis; In Vitro Techniques; Isotope Labeling; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Rats; Serine; Threonine; Tyrosine | 1982 |
A rapid microdetermination of phosphoserine, phosphothreonine, and phosphotyrosine in proteins by automatic cation exchange on a conventional amino acid analyzer.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrolysis; Myocardium; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1983 |
Polyamide thin-layer chromatography of phosphorylated tyrosine, threonine, and serine.
Topics: Chromatography, Thin Layer; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1983 |
Two different protein kinase activities are associated with the insulin receptor.
Topics: Animals; Caseins; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Histones; In Vitro Techniques; Isoenzymes; Liver; Male; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1983 |
Tyrosine protein kinase activity in normal rat tissues: brain.
Topics: Animals; Binding Sites; Brain; Cations, Divalent; Male; Nerve Tissue Proteins; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Structure-Activity Relationship; Tyrosine | 1984 |
Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.
Topics: Animals; Calmodulin; Cattle; Cell Nucleus; Cytosol; Enzyme Activation; Estradiol; Female; Kinetics; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Receptors, Estradiol; Receptors, Estrogen; Tyrosine; Uterus | 1984 |
Chemical properties, isolation, and analysis of O-phosphates in proteins.
Topics: Carbon Radioisotopes; Chemical Phenomena; Chemistry; Hydrolysis; Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tritium; Tyrosine | 1984 |
Phosphorylation pattern of large T antigens in mouse cells infected by simian virus 40 wild type or deletion mutants.
Topics: Animals; Antigens, Viral; Antigens, Viral, Tumor; Cells, Cultured; Kidney; Mice; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Serine; Simian virus 40; Threonine; Trypsin | 1982 |
Simian virus 40 large T antigen is phosphorylated at multiple sites clustered in two separate regions.
Topics: Adenosine Diphosphate Ribose; Animals; Antigens, Viral; Antigens, Viral, Tumor; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; Peptide Hydrolases; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Simian virus 40 | 1982 |
Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes.
Topics: Animals; Blood Proteins; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, Viral; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Mice; Oncogenes; Phosphoserine; Phosphothreonine; Receptors, Cell Surface; Sarcoma Viruses, Murine; Viral Proteins | 1982 |
Improved localization of phosphorylation sites in simian virus 40 large T antigen.
Topics: Antigens, Viral; Antigens, Viral, Tumor; Peptide Hydrolases; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Simian virus 40 | 1983 |
Metabolic turnover of phosphorylation sites in simian virus 40 large T antigen.
Topics: Antigens, Viral; Antigens, Viral, Tumor; Half-Life; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Serine; Simian virus 40; Temperature; Threonine | 1983 |
Detection of an 85,000-dalton phosphoprotein in ts110 murine sarcoma virus-infected cells with antiserum against a v-mos peptide.
Topics: Animals; Antibodies, Viral; Antibody Specificity; Defective Viruses; Electrophoresis, Polyacrylamide Gel; Gene Products, gag; Mice; Moloney murine leukemia virus; Phosphoserine; Phosphothreonine; Rats; Sarcoma Viruses, Murine; Viral Core Proteins; Viral Proteins | 1983 |
Effects of Zn2+ ions on protein phosphorylation in epithelial cell membranes.
Topics: Animals; Cations, Divalent; Cell Division; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelium; ErbB Receptors; Membrane Proteins; Mice; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Receptors, Cell Surface; Zinc | 1983 |
Phosphoprotein phosphatase activity of human prostate acid phosphatase.
Topics: Acid Phosphatase; Electrophoresis, Paper; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Kinetics; Male; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Prostate; Substrate Specificity | 1983 |
Comparison of nonphosphorylated and phosphorylated species of polyomavirus major capsid protein VP1 and identification of the major phosphorylation region.
Topics: Amino Acid Sequence; Autoradiography; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Polyomavirus; Viral Proteins; Viral Structural Proteins | 1983 |
Structure of the heme-regulated eukaryotic initiation factor 2 alpha kinase. End group analysis and phosphoaminoacid content.
Topics: Amino Acids; Chemical Phenomena; Chemistry; eIF-2 Kinase; Phosphoserine; Phosphothreonine; Protein Kinases | 1983 |
Phosphoproteins of chicken bone matrix. Proof of synthesis in bone tissue.
Topics: Animals; Bone and Bones; Chick Embryo; Chromatography, DEAE-Cellulose; Chromatography, Gel; Edetic Acid; Phosphoproteins; Phosphoserine; Phosphothreonine | 1984 |
[Identification and isolation of casein kinase type II from RNA-binding proteins of amphibian oocytes].
Topics: Adenosine Triphosphate; Animals; Carrier Proteins; Casein Kinases; Electrophoresis, Polyacrylamide Gel; Female; Guanosine Triphosphate; Heparin; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Kinases; Rana temporaria; RNA-Binding Proteins | 1984 |
Glycogen synthase in rat adipocytes and skeletal muscle is phosphorylated on both serine and threonine.
Topics: Adipose Tissue; Animals; Chromatography, Thin Layer; Glycogen Synthase; Macromolecular Substances; Male; Muscles; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Serine; Threonine | 1984 |
Sulfation and phosphorylation of the neural cell adhesion molecule, N-CAM.
Topics: Animals; Antigens, Surface; Brain; Cell Adhesion Molecules; Chick Embryo; Glycopeptides; In Vitro Techniques; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Sialic Acids; Sulfates | 1984 |
Ordered phosphorylation of 40S ribosomal protein S6 after serum stimulation of quiescent 3T3 cells.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media; Growth Substances; Mice; Molecular Weight; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Ribosomal Proteins; Ribosomes | 1983 |
Casein kinase I.
Topics: Animals; Casein Kinases; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Kinetics; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Potassium Chloride; Protein Kinases; Rabbits; Reticulocytes; Tissue Distribution | 1983 |
Inhibition of rabbit liver arylsulfatase B by phosphate esters.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; Chondro-4-Sulfatase; Chromatography, Affinity; Glucose-6-Phosphate; Glucosephosphates; Liver; Organophosphates; Organophosphorus Compounds; Phosphoserine; Phosphothreonine; Rabbits; Structure-Activity Relationship; Sugar Phosphates; Sulfatases | 1984 |
High-performance liquid chromatography of acid-stable and acid-labile phosphoamino acids.
Topics: Amino Acids; Arginine; Chromatography, High Pressure Liquid; Histidine; Lysine; Organophosphorus Compounds; Phosphoserine; Phosphothreonine | 1980 |
Serine phosphate, threonine phosphate and gamma-carboxyglutamic acid in normal and experimentally induced, pathologically calcified rat skin (topical cutaneous calciphylaxis).
Topics: 1-Carboxyglutamic Acid; Animals; Calciphylaxis; Dihydrotachysterol; Disease Models, Animal; Female; Glutamates; Ovalbumin; Phosphoserine; Phosphothreonine; Rats; Serine; Skin; Skin Diseases; Threonine | 1981 |
NMR study of the rotational isomerism around the C beta-O bond in phosphorylated alpha-amino acids: PSer and PThr.
Topics: Isomerism; Magnetic Resonance Spectroscopy; Phosphoserine; Phosphothreonine; Rotation; Serine; Threonine | 1982 |
Complex of simian virus 40 large tumor antigen and 48,000-dalton host tumor antigen.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral; Antigens, Viral, Tumor; Centrifugation, Density Gradient; Chromatin; Embryo, Mammalian; Fibroblasts; Mice; Mice, Inbred BALB C; Molecular Weight; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine | 1981 |
Changes in phosphoproteins of chicken bone matrix in vitamin D-deficient rickets.
Topics: Animals; Bone and Bones; Bone Development; Chickens; Organ Size; Phosphoproteins; Phosphoserine; Phosphothreonine; Rickets | 1982 |
Protein kinase activity immunoprecipitated from adenovirus infected cells by sera from tumor-bearing hamsters.
Topics: Adenoviruses, Human; Animals; Antibodies, Neoplasm; Antibody Specificity; Cell Line; Cricetinae; Humans; Immune Sera; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Protein Kinases | 1981 |
Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells.
Topics: Alkaline Phosphatase; Animals; Carcinoma, Ehrlich Tumor; DNA-Directed RNA Polymerases; Enzyme Activation; Mice; Neoplasm Proteins; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; RNA Polymerase II; Transcription Factors, General; Transcriptional Elongation Factors; Trypsin | 1981 |
Structural characterization of the phosphorylation sites of human erythrocyte spectrin.
Topics: Adenosine Triphosphate; Amino Acids; Erythrocytes; Humans; Macromolecular Substances; Membrane Proteins; Molecular Weight; Peptide Fragments; Phosphates; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Spectrin; Trypsin | 1980 |
Phosphodipeptide analysis of nonhistone nuclear proteins from Novikoff hepatoma ascites cells.
Topics: Amino Acids; Animals; Cell Nucleus; Chromosomal Proteins, Non-Histone; Dipeptides; Hydrolysis; Liver Neoplasms, Experimental; Male; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Rats | 1980 |
In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons.
Topics: Animals; Brain; Calcium; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Neurons; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Protein Phosphatase 2; Rats; Tacrolimus; tau Proteins | 1995 |
Unidirectional cross-phosphorylation between the granulocyte colony-stimulating factor and interleukin 3 receptors.
Topics: Amino Acids; Animals; Cell Differentiation; Cell Division; Cell Line; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Macromolecular Substances; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptors, Granulocyte Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Transfection; Tyrosine | 1993 |
Synergistic control mechanism for abnormal site phosphorylation of Alzheimer's diseased brain tau by kinase FA/GSK-3 alpha.
Topics: Alzheimer Disease; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Humans; Kinetics; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Substrate Specificity; tau Proteins; Tyrosine | 1993 |
GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Dogs; ErbB Receptors; Erythrocytes; G(M3) Ganglioside; Humans; Kinetics; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Tumor Cells, Cultured; Tyrosine | 1994 |
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Topics: 3-O-Methylglucose; Animals; Cell Line; Fibroblasts; Glucose; Humans; Insulin; Isoenzymes; Kinetics; Mannitol; Methylglucosides; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Multiple sites of phosphorylation within the alpha heavy chain of Chlamydomonas outer arm dynein.
Topics: Animals; Centrifugation, Density Gradient; Chlamydomonas; Dyneins; Flagella; Pancreatic Elastase; Peptide Fragments; Phosphates; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Trypsin; Tyrosine | 1994 |
Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.
Topics: Aluminum Compounds; Calcium; CD3 Complex; Cell Line; Cytokines; Fluorides; Glutathione; Humans; In Vitro Techniques; Oxidation-Reduction; Phosphoserine; Phosphothreonine; Phosphotyrosine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Terpenes; Thapsigargin; Tyrosine | 1994 |
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Topics: Adenocarcinoma; Amino Acid Sequence; Antibodies; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Casein Kinases; Caseins; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Kinetics; Lung; Lung Neoplasms; Molecular Sequence Data; Myelin Basic Protein; Peptides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Proteins; Substrate Specificity; Tyrosine | 1994 |
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glycogen Synthase Kinases; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Muscles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rabbits; Recombinant Proteins; Tyrosine | 1994 |
Steel factor stimulates the serine/threonine phosphorylation of the interleukin-3 receptor.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Cell Line; DNA; Electrophoresis, Polyacrylamide Gel; Hematopoietic Cell Growth Factors; Interleukin-3; Kinetics; Macromolecular Substances; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Receptors, Interleukin-3; Recombinant Proteins; Stem Cell Factor; Tetradecanoylphorbol Acetate; Thymidine; Transfection | 1994 |
Autophosphorylation-activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2A.
Topics: Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Glycogen Synthase Kinase 3; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protamine Kinase; Protein Kinases; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Substrate Specificity; Tyrosine | 1994 |
Platelet-derived growth factor stimulates phosphorylation of growth factor receptor-binding protein-2 in vascular smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; ErbB Receptors; GRB2 Adaptor Protein; In Vitro Techniques; Muscle, Smooth, Vascular; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; Rats; Signal Transduction; Tyrosine | 1994 |
Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.
Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; Cloning, Molecular; DNA Primers; Molecular Sequence Data; Phosphoserine; Phosphothreonine; Phosphotyrosine; Plant Proteins; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
1H and 31P NMR spectroscopy of phosphorylated model peptides.
Topics: Amino Acid Sequence; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Phosphopeptides; Phosphorus; Phosphoserine; Phosphothreonine; Phosphotyrosine; Structure-Activity Relationship; Tyrosine | 1994 |
Selective phosphoamino acid enrichment by organic solvent fractionation.
Topics: Acetone; Chemical Fractionation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tyrosine | 1994 |
Differential phosphorylation of a 57-KDa protein tyrosine kinase during egg activation.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Female; Fertilization; Genes, src; Male; Molecular Sequence Data; Molecular Weight; Oocytes; Peptides; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Sea Urchins; Spermatozoa; Tyrosine | 1995 |
Role of p70 S6 protein kinase in angiotensin II-induced protein synthesis in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Imidazoles; Kinetics; Losartan; Male; Molecular Weight; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred BN; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; Sirolimus; Tetrazoles; Tyrosine | 1995 |
Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction.
Topics: Acetylcholine; Animals; Binding Sites; Cytoskeletal Proteins; Dogs; Immunosorbent Techniques; Muscle Contraction; Muscle, Smooth; Paxillin; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Talin; Trachea; Tyrosine; Vinculin | 1995 |
Dual modulation of phosphorylation of a 60 kDa nuclear protein in interferon-alpha treated Daudi cells.
Topics: B-Lymphocytes; Cell Line; Humans; Interferon alpha-2; Interferon-alpha; Molecular Weight; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tyrosine | 1995 |
In vivo and in vitro serine/threonine phosphorylations of epidermal growth factor receptor upon entry into the cell cycle.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Culture Media, Serum-Free; Electrophoresis, Gel, Two-Dimensional; ErbB Receptors; Flow Cytometry; Glioblastoma; Humans; Interphase; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; S Phase; Tyrosine | 1995 |
Ganglioside GM1 binds to the Trk protein and regulates receptor function.
Topics: Animals; Cell Differentiation; G(M1) Ganglioside; Kinetics; Nerve Growth Factors; Neurites; Neurofilament Proteins; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Tyrosine | 1995 |
A new approach to phosphoserine, phosphothreonine and phosphotyrosine synthons and to thiophospho analogs. Stepwise synthesis of mono- and multiphosphorylated phosphopeptides related to src-protein kinase.
Topics: Amino Acid Sequence; CSK Tyrosine-Protein Kinase; Molecular Sequence Data; Organothiophosphates; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 1995 |
In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase.
Topics: Base Sequence; Binding Sites; Cell Line; DNA Primers; Gene Products, nef; Genes, nef; Glutathione Transferase; HIV-1; Humans; Kinetics; Molecular Sequence Data; nef Gene Products, Human Immunodeficiency Virus; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Sequence Deletion; Tyrosine | 1995 |
Analysis of phosphorylhydroxyamino acids present in hydrolyzed cell extracts using dabsyl derivatization.
Topics: Cell Extracts; Chromatography, Thin Layer; Electrophoresis; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; p-Dimethylaminoazobenzene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Protein-Tyrosine Kinases; Quercetin; Tumor Cells, Cultured; Tyrosine | 1995 |
Protein phosphorylation on serine, threonine, and tyrosine residues modulates membrane-protein interactions and transcriptional regulation in Salmonella typhimurium.
Topics: Adenosine Triphosphate; Bacterial Proteins; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Bacterial; Magnetic Resonance Spectroscopy; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Kinases; Protein-Tyrosine Kinases; Salmonella typhimurium; Tyrosine | 1995 |
Identification of Lck-binding elements in tip of herpesvirus saimiri.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Chlorocebus aethiops; DNA Primers; Herpesvirus 2, Saimiriine; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Point Mutation; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Spodoptera; Structure-Activity Relationship; Transfection; Tyrosine; Viral Proteins | 1995 |
The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.
Topics: Androstadienes; Animals; CD28 Antigens; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Lymphocyte Activation; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1995 |
Biochemical characterization and localization of JC virus large T antigen phosphorylation domains.
Topics: Animals; Antigens, Polyomavirus Transforming; Cell Line, Transformed; Humans; JC Virus; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Rats; Recombinant Fusion Proteins; Sequence Deletion | 1995 |
Effects of cooling temperature on the separation of phosphoamino acids.
Topics: Cold Temperature; Electrophoresis; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1995 |
Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.
Topics: Amino Acid Sequence; Amino Acids; Base Sequence; Casein Kinase II; CDC2 Protein Kinase; Glutathione Transferase; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Peptides; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Substrate Specificity | 1995 |
Endogenous phosphorylation of distinct gamma-aminobutyric acid type A receptor polypeptides by Ser/Thr and Tyr kinase activities associated with the purified receptor.
Topics: Affinity Labels; Animals; Blotting, Western; Cattle; Cell Membrane; Cerebral Cortex; Kinetics; Macromolecular Substances; Muscimol; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, GABA-A; Substrate Specificity; Thermodynamics | 1995 |
Sequencing of the tuf1 gene and the phosphorylation pattern of EF-Tu1 during development and differentiation in Streptomyces collinus producing kirromycin.
Topics: Amino Acid Sequence; Base Sequence; DNA, Bacterial; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunosorbent Techniques; Isoelectric Focusing; Molecular Sequence Data; Peptide Elongation Factor Tu; Phosphorylation; Phosphoserine; Phosphothreonine; Pyridones; Sequence Analysis, DNA; Streptomyces | 1995 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.
Topics: Animals; Cell Differentiation; Mitogens; Nerve Growth Factors; Neurons; Nuclear Proteins; Oncogene Protein pp60(v-src); Oncogenes; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 1993 |
Atrial natriuretic factor stimulates phosphorylation of a 52-kDa calmodulin-binding protein in vascular smooth muscle cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Calmodulin-Binding Proteins; Cells, Cultured; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Endothelins; Male; Muscle, Smooth, Vascular; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Rats; Rats, Inbred Strains; Rats, Wistar; Tyrosine | 1993 |
A purine analog-sensitive protein kinase activity associates with Trk nerve growth factor receptors.
Topics: 2-Aminopurine; Animals; Histones; Immunosorbent Techniques; Kinetics; Myelin Basic Protein; Nerve Growth Factors; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Purines; Rats; Receptor, trkA; Receptors, Nerve Growth Factor; Thioguanine | 1993 |
Identification of O-phosphoamino acids in urine hydrolysate by gas chromatography-mass spectrometry.
Topics: Amino Acids; Chromatography, DEAE-Cellulose; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Phosphoserine; Phosphothreonine; Phosphotyrosine; Photometry; Tyrosine | 1993 |
The cytoplasmic domain of P-selectin is phosphorylated on serine and threonine residues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Alprostadil; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; P-Selectin; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Platelet Membrane Glycoproteins; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1993 |
Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo.
Topics: Actin Cytoskeleton; Animals; Cell Compartmentation; Cell Division; Concanavalin A; Cytoskeleton; Dictyostelium; Membrane Proteins; Mutation; Myosins; Octoxynol; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Tyrosine | 1993 |
Phosphorylation of two human neurochordins by mammalian casein kinase 1.
Topics: Adenosine Triphosphate; Adolescent; Autoradiography; Brain; Casein Kinases; Electrophoresis, Polyacrylamide Gel; Female; Humans; Membrane Glycoproteins; Molecular Weight; Nerve Tissue Proteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1993 |
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin.
Topics: Amino Acid Sequence; Animals; Calcineurin; Calcium; Calmodulin; Calmodulin-Binding Proteins; Casein Kinases; Cattle; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Kinetics; Manganese; Muscle, Skeletal; Myocardium; Nerve Tissue Proteins; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Phosphatase 1; Rabbits; Rats; Recombinant Proteins; Serine; Substantia Nigra; Threonine; Thymus Gland | 1995 |
Regulation of sialyltransferase activities by phosphorylation and dephosphorylation.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Brain; Cattle; Homeostasis; Kinetics; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rats; Rats, Wistar; Sheep; Sialyltransferases | 1995 |
Phosphorylation site-specific antibodies to cardiac phospholamban.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Antibody Specificity; Calcium-Binding Proteins; Molecular Sequence Data; Myocardium; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Rats; Serine; Threonine | 1995 |
Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C.
Topics: Adenosine Triphosphate; Autoradiography; Carbon-Nitrogen Ligases; Kinetics; Ligases; Phosphates; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Saccharomyces cerevisiae; Serine; Threonine | 1995 |
A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Chemokine CCL2; Chemotactic Factors; Cycloheximide; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Genes, Immediate-Early; In Vitro Techniques; Mice; Molecular Sequence Data; NF-kappa B; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Phosphoserine; Phosphothreonine; Platelet-Derived Growth Factor; Transcription, Genetic | 1995 |
Identification of a casein kinase activity found elevated in human cytomegalovirus transformed cells.
Topics: Amino Acid Sequence; Casein Kinase II; Cell Line; Cell Transformation, Viral; Cytomegalovirus; Cytoplasm; Humans; Immunoblotting; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Substrate Specificity | 1995 |
Proteolysis of p6.9 induced by cytochalasin D in Autographa californica M nuclear polyhedrosis virus-infected cells.
Topics: Actins; Animals; Cell Line; Cytochalasin D; Nucleopolyhedroviruses; Occlusion Body Matrix Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Spodoptera; Viral Proteins; Viral Structural Proteins; Virus Replication | 1995 |
Further studies into the Boc/solid-phase synthesis of Ser(P)- and Thr(P)-containing peptides.
Topics: Amino Acid Sequence; Formic Acid Esters; Molecular Sequence Data; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine | 1994 |
Phosphorylation of the adenomatous polyposis coli protein and its possible regulatory effects in cells.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Cell Line; Colonic Neoplasms; Cytoskeletal Proteins; Dipeptides; Electrophoresis, Polyacrylamide Gel; Genes, APC; Humans; Lymphocytes; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Tumor Cells, Cultured | 1995 |
The phosphorylated ribosomal protein S7 in Tetrahymena is homologous with mammalian S4 and the phosphorylated residues are located in the C-terminal region. Structural characterization of proteins separated by two-dimensional polyacrylamide gel electropho
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cyanogen Bromide; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Mass Spectrometry; Methanococcus; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Ribosomal Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Tetrahymena thermophila; Trypsin | 1995 |
Synthesis of phosphopeptides containing O-phosphoserine and O-phosphothreonine.
Topics: Amino Acid Sequence; Indicators and Reagents; Molecular Biology; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine | 1994 |
Erythropoietin stimulates serine kinase activity in erythropoietin-dependent cells.
Topics: Animals; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Leukemia, Erythroblastic, Acute; Mice; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Signal Transduction; Tumor Cells, Cultured | 1994 |
Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Heparin; Humans; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Substrate Specificity; Swine; tau Proteins; Trypsin | 1994 |
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Ethers, Cyclic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Immunosuppressive Agents; Kinetics; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Polyenes; Protein Phosphatase 1; Radioisotope Dilution Technique; Sirolimus; Tumor Cells, Cultured | 1994 |
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Cell Compartmentation; Cell Nucleus; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Activation; Molecular Sequence Data; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Recombinant Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Structure-Activity Relationship; Threonine; Xenopus | 1994 |
Phosphorylation of cytadherence-accessory proteins in Mycoplasma pneumoniae.
Topics: Amino Acids; Bacterial Adhesion; Bacterial Proteins; Cell Adhesion Molecules; Cytoskeleton; Isotope Labeling; Mycoplasma pneumoniae; Octoxynol; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests | 1994 |
Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2.
Topics: Amino Acid Sequence; Animals; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Eukaryotic Initiation Factor-2; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rabbits | 1994 |
Phosphorylation of ornithine decarboxylase at both serine and threonine residues in the ODC-overproducing, Abelson virus-transformed RAW264 cell line.
Topics: Abelson murine leukemia virus; Animals; Cell Line, Transformed; Mice; Ornithine Decarboxylase; Phosphorylation; Phosphoserine; Phosphothreonine | 1994 |
Substrate-regulated, cAMP-dependent phosphorylation, denaturation, and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Denaturation; Rats; Rats, Sprague-Dawley; Serine; Substrate Specificity; Testosterone | 1994 |
Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Chick Embryo; Coturnix; Cytoplasm; Mitogens; Mitosis; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Transcriptional Activation | 1994 |
Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Binding Sites; Cells, Cultured; Endoglin; Endothelium, Vascular; Fibroblasts; Humans; Immunosorbent Techniques; Isoquinolines; Membrane Glycoproteins; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinase C; Receptors, Cell Surface; Recombinant Proteins; Transfection; Transforming Growth Factor beta; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1994 |
Identification of sites of serine and threonine phosphorylation via site-directed mutagenesis--site transformation versus site elimination.
Topics: Adenosine Triphosphate; Animals; Humans; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis; Protein Kinases; Proteins; Radioisotope Dilution Technique; Recombinant Proteins; Serine; Threonine | 1994 |
Biochemical properties of the autophosphorylation of RLK5, a receptor-like protein kinase from Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; Electrophoresis; Escherichia coli; Gene Expression; Kinetics; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins | 1994 |
Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Follicle Stimulating Hormone; Humans; Inositol Phosphates; Phorbol Esters; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rats; Receptors, FSH; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Serine/threonine phosphorylation of the gamma-subunit after activation of the high-affinity Fc receptor for immunoglobulin G.
Topics: Amino Acid Sequence; Cell Line; Gene Expression; Humans; Immunoglobulin G; Interferon-gamma; Kinetics; Macromolecular Substances; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Receptors, IgG; Recombinant Proteins; Signal Transduction; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
Topics: Amino Acid Sequence; Autoradiography; Blood Platelets; Chromatography, High Pressure Liquid; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Microfilament Proteins; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Substrate Specificity | 1994 |
Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.
Topics: Animals; Blastoderm; Cell Membrane; Cell Nucleus; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Insect Hormones; Membrane Glycoproteins; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Receptors, Cell Surface; Toll-Like Receptors; Transcription Factors | 1994 |
Anti-phosphoserine and anti-phosphothreonine antibodies modulate autophosphorylation of the insulin receptor but not EGF receptor.
Topics: Animals; Antibodies; Cells, Cultured; ErbB Receptors; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Receptor, Insulin | 1993 |
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Humans; Microtubule-Associated Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Proline-Directed Protein Kinases; Protein Serine-Threonine Kinases; tau Proteins | 1993 |
Quantification of subnanomolar amounts of phosphate bound to seryl and threonyl residues in phosphoproteins using alkaline hydrolysis and malachite green.
Topics: Adenosine Triphosphate; Caseins; Coloring Agents; Cyclic AMP-Dependent Protein Kinases; Fibrinogen; Histones; Hydrogen-Ion Concentration; Hydrolysis; Microchemistry; Ovalbumin; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protamines; Rosaniline Dyes; Spectrophotometry | 1993 |
Identification of the threonine phosphorylation sites on the polyomavirus major capsid protein VP1: relationship to the activity of middle T antigen.
Topics: Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Capsid; Capsid Proteins; Cells, Cultured; DNA Mutational Analysis; Mass Spectrometry; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Polyomavirus; Sequence Analysis; Threonine; Virion | 1994 |
Autophosphorylation of degradation products of arginyl-tRNA synthetase protein, isolated from Bom:NMRI mouse liver.
Topics: Adenosine Triphosphate; Animals; Arginine-tRNA Ligase; Binding Sites; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Liver; Mice; Molecular Weight; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; RNA, Transfer, Arg | 1993 |
Identification of two phosphorylation motifs in bovine osteopontin.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Female; Milk; Molecular Sequence Data; Osteopontin; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Sialoglycoproteins | 1994 |
Characterization of the 50 kDa protein phosphorylated in concanavalin A-stimulated mouse T cells.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium-Binding Proteins; Chromatography, High Pressure Liquid; Concanavalin A; Electrophoresis, Gel, Two-Dimensional; Female; Lymphocyte Activation; Mice; Microfilament Proteins; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Sequence Alignment; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Pharmacokinetic study of the relative bioavailability and bioequivalence after oral intensive or repeated short term treatment with two polyamino acid formulations.
Topics: Administration, Oral; Adult; Amino Acids; Arginine; Biological Availability; Drug Administration Schedule; Female; Formularies as Topic; Glutamine; Humans; Male; Phosphoserine; Phosphothreonine; Therapeutic Equivalency; Vitamin B 12 | 1993 |
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.
Topics: Animals; Biological Transport; Cell Compartmentation; Cell Cycle; Cell Nucleus; Fibroblasts; Microinjections; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Rats; Retinoblastoma Protein; Subcellular Fractions | 1993 |
The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.
Topics: Amino Acid Sequence; Animals; Biological Transport; Bovine papillomavirus 1; CDC2 Protein Kinase; Cell Compartmentation; Cell Line; Cell Nucleus; DNA Mutational Analysis; DNA Replication; DNA-Binding Proteins; DNA, Viral; Fluorescent Antibody Technique; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Sorting Signals; Sequence Homology, Amino Acid; Viral Proteins | 1993 |
Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts.
Topics: Amino Acid Sequence; Animals; Calcium-Binding Proteins; Cyclic AMP; Female; Guinea Pigs; Heart; Isoproterenol; Molecular Sequence Data; Myocardial Contraction; Myofibrils; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Receptors, Adrenergic, beta; Sarcolemma; Sarcoplasmic Reticulum; Troponin; Troponin I | 1993 |
Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues.
Topics: Cell Line; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Durapatite; Humans; Hydroxyapatites; Kinetics; Mitogen-Activated Protein Kinase Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Tumor Cells, Cultured | 1993 |
Identification of the phosphorylation sequence in the cytoplasmic tail of the varicella-zoster virus Fc receptor glycoprotein gpI.
Topics: Amino Acid Sequence; Casein Kinases; Cloning, Molecular; Escherichia coli; Genes, Viral; HeLa Cells; Herpesvirus 3, Human; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphoserine; Phosphothreonine; Polymerase Chain Reaction; Protein Kinases; Receptors, Fc; Receptors, Virus; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transfection; Viral Envelope Proteins | 1993 |
Characterization of type II activin receptors. Binding, processing, and phosphorylation.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Cell Line; Glycosylation; Immunosorbent Techniques; Inhibins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Receptors, Cell Surface; Recombinant Proteins; Transfection; Trypsin | 1993 |
Preparation of anti-phosphoserine and anti-phosphothreonine antibodies and their application in the study of insulin- and EGF-induced phosphorylation.
Topics: Animals; Antibodies; CHO Cells; Chromatography, Affinity; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Kinetics; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Receptor, Insulin; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Purification of a 90-kDa protein (Band VII) from cardiac sarcoplasmic reticulum. Identification as calnexin and localization of casein kinase II phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Binding Proteins; Calnexin; Casein Kinase II; Cloning, Molecular; DNA; Dogs; Endoplasmic Reticulum; Molecular Sequence Data; Molecular Weight; Myocardium; Oligodeoxyribonucleotides; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Sarcoplasmic Reticulum; Trypsin | 1993 |
cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain.
Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; Chickens; Desmin; In Vitro Techniques; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinases | 1993 |
Phosphorylation sites in bovine rhodopsin.
Topics: Animals; Cattle; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Rhodopsin; Rod Cell Outer Segment; Sequence Analysis | 1993 |
Transition state and rate-limiting step of the reaction catalyzed by the human dual-specificity phosphatase, VHR.
Topics: Amino Acid Sequence; Dual-Specificity Phosphatases; Humans; Kinetics; Models, Theoretical; Molecular Sequence Data; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Tyrosine Phosphatases; Substrate Specificity | 1995 |
Posttranslational modifications of bovine osteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sites.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Conserved Sequence; Female; Glycosylation; Humans; Mass Spectrometry; Milk; Molecular Sequence Data; Osteopontin; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Serine; Sialoglycoproteins | 1995 |
Chemical synthesis of phosphopeptides using the arylthio group for protection of phosphate: application to identification of cdc2 kinase phosphorylation sites.
Topics: Amino Acid Sequence; Binding Sites; CDC2 Protein Kinase; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Retinoblastoma Protein | 1995 |
Involvement of protein phosphatase-1 in cytoskeletal organization of cultured endothelial cells.
Topics: Actins; Animals; Blotting, Western; Carbazoles; Cell Nucleus; Cells, Cultured; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indole Alkaloids; Marine Toxins; Mice; Microtubules; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Phosphatase 1; Umbilical Veins | 1995 |
The 110-kD spindle pole body component of Saccharomyces cerevisiae is a phosphoprotein that is modified in a cell cycle-dependent manner.
Topics: Anaphase; Calmodulin-Binding Proteins; CDC28 Protein Kinase, S cerevisiae; Cell Cycle; Centrosome; Cyclins; Cytoskeletal Proteins; Fungal Proteins; Mitosis; Molecular Weight; Mutation; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spindle Apparatus; Structure-Activity Relationship | 1996 |
Induction and phosphorylation of protein kinase C-alpha and mitogen-activated protein kinase by hypoxia and by radiation in Chinese hamster V79 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Compartmentation; Cell Line; Cricetinae; Cricetulus; Enzyme Induction; Hypoxia; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; X-Rays | 1996 |
Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Kinetics; Mice; Mutagenesis; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis; Proteins; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Deletion; Sequence Tagged Sites; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Phosphorylation of Vif and its role in HIV-1 replication.
Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Cells, Cultured; DNA Primers; Enzyme Inhibitors; Gene Products, vif; Genetic Complementation Test; HIV-1; Humans; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Structure-Activity Relationship; vif Gene Products, Human Immunodeficiency Virus; Virus Replication | 1996 |
Crystal structure of the dual specificity protein phosphatase VHR.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Dual Specificity Phosphatase 3; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Sequence Alignment; Substrate Specificity; Water; Yersinia | 1996 |
Phosphotyrosyl protein phosphatase-like activity of a clonal osteoblastic cell line (MC3T3-E1 cell).
Topics: 3T3 Cells; Animals; Cell Line; Clone Cells; Cyclic AMP; Enzyme Inhibitors; Ethers, Cyclic; Histones; Hydrogen-Ion Concentration; Hydrolysis; Mice; Muramidase; Okadaic Acid; Osteoblasts; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Vanadates; Zinc | 1995 |
Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells.
Topics: Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; DNA; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Mice; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1996 |
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.
Topics: Amino Acid Sequence; Animals; Base Sequence; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cloning, Molecular; Cyclins; Enzyme Activation; Molecular Sequence Data; Mutation; Oocytes; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Proteins; Xenopus; Xenopus Proteins | 1996 |
O-phospho-DL-threonine and O-phospho-L-threonine compared with their serine analogs.
Topics: Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Structure; Phosphoserine; Phosphothreonine | 1996 |
Intramolecular interactions regulate serine/threonine phosphorylation of vinculin.
Topics: Amino Acid Sequence; Animals; Gizzard, Avian; Homeostasis; Molecular Weight; Muscle, Smooth; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Serine; Threonine; Turkeys; Vinculin | 1996 |
Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
Topics: Amino Acid Sequence; Binding Sites; Calmodulin; Calmodulin-Binding Proteins; Chromatography, High Pressure Liquid; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Proteins | 1996 |
Phosphorylation of extracellular domains of T-lymphocyte surface proteins. Constitutive serine and threonine phosphorylation of the T cell antigen receptor ectodomains.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Antibodies, Monoclonal; Biological Evolution; Cell Line; Conserved Sequence; Guanosine Triphosphate; Humans; Lymphoma; Membrane Proteins; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases | 1996 |
Analysis of the phosphoamino acid content of phosphoproteins.
Topics: Amino Acids; Chromatography, Thin Layer; Isotope Labeling; p-Dimethylaminoazobenzene; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1996 |
Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60c-src kinase.
Topics: Electrophoresis, Polyacrylamide Gel; Enzyme Activation; ErbB Receptors; GTPase-Activating Proteins; Histones; Humans; Kinetics; Magnesium; Manganese; Ovalbumin; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Polyglutamic Acid; Polylysine; Proteins; ras GTPase-Activating Proteins; src-Family Kinases; Trypsin; Tumor Cells, Cultured; Tyrosine | 1996 |
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.
Topics: Amino Acid Sequence; Animals; Arsenites; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Chymotrypsin; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Trypsin | 1995 |
Determination of phosphoserine in human pepsinogens.
Topics: Chromatography; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Gastric Juice; Humans; Hydrolysis; Pepsinogens; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1996 |
Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.
Topics: Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; eIF-2 Kinase; Enzyme Induction; Haplorhini; Humans; Interferon-alpha; Kidney; Mutagenesis, Site-Directed; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Protein Serine-Threonine Kinases; Recombinant Proteins; Saccharomyces cerevisiae; Transfection | 1996 |
The properties of the protein tyrosine phosphatase PTPMEG.
Topics: Amino Acid Sequence; Animals; Antibodies; Calpain; Cell Line; COS Cells; Cytoskeletal Proteins; Enzyme Activation; Erythrocyte Membrane; Humans; Kinetics; Membrane Proteins; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Tyrosine Phosphatases; Recombinant Proteins; Sequence Homology, Amino Acid; Spodoptera; Transfection; Trypsin | 1996 |
CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.
Topics: Animals; Casein Kinase II; CHO Cells; Cricetinae; Cricetulus; DNA, Complementary; Humans; Macromolecular Substances; Neoplasm Proteins; Neprilysin; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; src-Family Kinases; Tumor Cells, Cultured | 1996 |
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; DNA; fas Receptor; Flow Cytometry; Gene Expression Regulation; Genes, Reporter; Immunoblotting; Mice; Mutagenesis; NF-kappa B; Phosphatidylserines; Phosphoserine; Phosphothreonine; Proteins; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor; Transfection | 1996 |
Inhibition of interleukin-2-mediated DNA synthesis in activated human T-lymphoblasts by okadaic acid is accompanied by hyperphosphorylation of lck.
Topics: Blotting, Western; Cell Cycle; Cell Division; DNA; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; Interleukin-2; Isoenzymes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Okadaic Acid; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; src-Family Kinases; T-Lymphocytes | 1995 |
Tyrosine phosphorylation of myelin protein PO.
Topics: Animals; Hydrolysis; Male; Myelin P0 Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Vanadates | 1996 |
Phosphorylation and activation of smooth muscle myosin light chain kinase by MAP kinase and cyclin-dependent kinase-1.
Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; CDC2 Protein Kinase; Chickens; Enzyme Activation; Muscle, Smooth; Myosin-Light-Chain Kinase; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases | 1996 |
Insulin promotes and cyclic adenosine 3',5'-monophosphate impairs functional insertion of insulin receptors in the plasma membrane of rat adipocytes: evidence for opposing effects of tyrosine and serine/threonine phosphorylation.
Topics: Adipocytes; Affinity Labels; Animals; Cell Membrane; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Histocompatibility Antigens Class I; Immunoblotting; Insulin; Male; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Type C Phospholipases | 1997 |
Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; GRB2 Adaptor Protein; Humans; Isoenzymes; Membrane Proteins; Phospholipase C gamma; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins pp60(c-src); Rats; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Type C Phospholipases | 1997 |
Are phosphorylated tyrosine residues of certain receptors involved in inducing transitory covalent protein cross-linking?
Topics: Animals; Models, Chemical; Models, Structural; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Receptors, Cell Surface; Receptors, Fc; Signal Transduction; Static Electricity | 1997 |
Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Survival; Cell Transformation, Neoplastic; Mice; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-myc; Sequence Deletion; Structure-Activity Relationship; Transcriptional Activation; Tumor Cells, Cultured | 1997 |
Biochemical evidence that the phosphorylated tyrosines, serines, and threonines on the aggregated high affinity receptor for IgE are in the immunoreceptor tyrosine-based activation motifs.
Topics: Amino Acid Sequence; Molecular Sequence Data; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Receptor Aggregation; Receptors, IgE; src-Family Kinases | 1997 |
Analysis of sites of protein phosphorylation.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Electrophoresis; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Sequence Analysis | 1997 |
Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4.
Topics: Animals; COS Cells; DNA-Binding Proteins; Glycosylation; Hepatocyte Nuclear Factor 4; Nuclear Proteins; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Structure, Tertiary; Rats; Recombinant Proteins; Spodoptera; Structure-Activity Relationship; Transcription Factors | 1997 |
The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; CSK Tyrosine-Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histones; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Protamine Kinase; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; src-Family Kinases; Xenopus laevis | 1997 |
Purification and characterization of protein kinase CK2 from Candida albicans: evidence for the presence of two distinct regulatory subunits beta and beta'.
Topics: Candida albicans; Casein Kinase II; Fungal Proteins; Heparin; Isoenzymes; Kinetics; Macromolecular Substances; Molecular Weight; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases | 1997 |
Phosphorylation of tick-borne encephalitis virus NS5 protein.
Topics: Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Blotting, Western; Cells, Cultured; DNA-Directed RNA Polymerases; Encephalitis Viruses, Tick-Borne; Female; Kidney; Kinetics; Mice; Mice, Inbred BALB C; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; RNA, Viral; Swine; Viral Nonstructural Proteins | 1997 |
Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae.
Topics: Blotting, Northern; Cell Division; Gene Expression Regulation, Fungal; Genes, Fungal; Microscopy, Phase-Contrast; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Saccharomyces cerevisiae; Substrate Specificity | 1997 |
The erythropoietin-sensitive membrane phosphoprotein, pp43, is a protein serine/threonine kinase.
Topics: Animals; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Erythropoietin; Hydrogen-Ion Concentration; Leukemia, Erythroblastic, Acute; Membrane Proteins; Mice; Osmolar Concentration; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Potassium Chloride; Protein Serine-Threonine Kinases; Recombinant Proteins; Tumor Cells, Cultured | 1997 |
Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Humans; Immunodominant Epitopes; Mice; Molecular Sequence Data; Neurofibrillary Tangles; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Structure, Secondary; Substrate Specificity; tau Proteins | 1997 |
Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin.
Topics: Adjuvants, Immunologic; Bryostatins; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Lactones; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrolides; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
T cell receptor-induced phosphorylation of Sos requires activity of CD45, Lck, and protein kinase C, but not ERK.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; GRB2 Adaptor Protein; Humans; JNK Mitogen-Activated Protein Kinases; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Son of Sevenless Proteins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.
Topics: B7-1 Antigen; CD28 Antigens; Enzyme Activation; Enzyme Inhibitors; Humans; Jurkat Cells; Ligands; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1997 |
EGF receptor phosphorylation is affected by ionizing radiation.
Topics: Adenosine Triphosphate; Cell Division; Cell Line; Cell Membrane; Cesium Radioisotopes; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Gamma Rays; Humans; Kinetics; Methionine; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1997 |
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Compartmentation; Cell Nucleus; COS Cells; Enzyme Activation; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Mitogens; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Substrate Specificity; Tissue Distribution | 1997 |
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
Topics: Amino Acid Isomerases; Antibodies, Monoclonal; Binding Sites; Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; Epitopes; Heat-Shock Proteins; HeLa Cells; Humans; Isomerism; Mitosis; Models, Molecular; NIMA-Interacting Peptidylprolyl Isomerase; Oligopeptides; Peptide Library; Peptidylprolyl Isomerase; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Protein Conformation; Recombinant Fusion Proteins; Substrate Specificity; Tacrolimus Binding Proteins | 1997 |
Regulation of PtdIns4P 5-kinase C by thrombin-stimulated changes in its phosphorylation state in human platelets.
Topics: Alkaline Phosphatase; Blood Platelets; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Humans; Okadaic Acid; Peptide Mapping; Phosphatidylinositol 4,5-Diphosphate; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Thrombin; Trypsin | 1998 |
Phosphoproteins regulated by the interaction of high-density lipoprotein with human skin fibroblasts.
Topics: Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins E; Biological Transport; Carrier Proteins; Cells, Cultured; Cholesterol; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Lipoproteins, HDL; Male; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteins; Receptors, Lipoprotein; RNA-Binding Proteins; Signal Transduction; Skin | 1997 |
Oxidant inhibition of alphaLbeta2 integrin adhesion: evidence for coordinate effects on conformation and cytoskeleton linkage.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Arsenicals; Cell Adhesion; Cells, Cultured; Cytoskeleton; Humans; Integrins; Killer Cells, Natural; Lymphocyte Function-Associated Antigen-1; Oxidants; Oxidation-Reduction; Phosphoserine; Phosphothreonine; Signal Transduction; Sulfhydryl Compounds; Temperature; Tetradecanoylphorbol Acetate | 1998 |
Lipid-regulated kinases: some common themes at last.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Cell Membrane; Cloning, Molecular; Cytosol; Enzyme Activation; Models, Chemical; Phosphatidylinositol Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction | 1998 |
The PA influenza virus polymerase subunit is a phosphorylated protein.
Topics: Animals; Blotting, Western; Casein Kinase II; COS Cells; DNA-Binding Proteins; DNA-Directed RNA Polymerases; Electrophoresis, Gel, Two-Dimensional; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; RNA-Dependent RNA Polymerase; Transfection; Viral Proteins | 1998 |
Mechanisms involved in the acidosis enhancement of the isoproterenol-induced phosphorylation of phospholamban in the intact heart.
Topics: Acidosis; Adenosine Triphosphatases; Animals; Calcium; Calcium-Binding Proteins; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Wistar; Sarcoplasmic Reticulum | 1998 |
Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition.
Topics: Animals; Catalysis; Cattle; Hydrogen-Ion Concentration; Isomerism; Kinetics; NIMA-Interacting Peptidylprolyl Isomerase; Oligopeptides; Osmolar Concentration; Peptidylprolyl Isomerase; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Protein Conformation; Serine; Substrate Specificity; Threonine | 1998 |
Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Compartmentation; Cytosol; Insulin; Insulin Receptor Substrate Proteins; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Receptor, Insulin; Time Factors | 1998 |
Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Aorta; Azepines; Blotting, Western; Cell Line; Dinoprost; Enzyme Inhibitors; Kinetics; Mice; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Staurosporine; Wortmannin | 1998 |
Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine.
Topics: Animals; Cell Line; Fibroblasts; Glutathione Transferase; Isoenzymes; Kinetics; Molecular Weight; Phospholipase D; Phosphoproteins; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinase C-alpha; Rats; Recombinant Fusion Proteins; Spodoptera; Tetradecanoylphorbol Acetate; Transfection | 1998 |
ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway.
Topics: Alkaline Phosphatase; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Humans; Insulin; Nuclear Proteins; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Receptors, LDL; Recombinant Proteins; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Transfection | 1998 |
Identification of phosphoproteins coupled to initiation of motility in live epididymal mouse sperm.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Epididymis; Humans; Male; Mice; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Sperm Capacitation; Sperm Motility; Spermatozoa | 1998 |
Fragmentation of phosphopeptides in an ion trap mass spectrometer.
Topics: Amino Acid Sequence; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1998 |
Co-ordinated changes in cAMP, phosphorylated phospholamban, Ca2+ and contraction following beta-adrenergic stimulation of rat heart.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Cyclic AMP; Fluorescent Dyes; Fura-2; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 1998 |
Protein kinases A and C phosphorylate purified Ca2+-ATPase from rat cortex, cerebellum and hippocampus.
Topics: Animals; Brain; Calcium-Transporting ATPases; Cell Membrane; Cerebellum; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Isoenzymes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Rats; Rats, Wistar; Synaptosomes | 1998 |
The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.
Topics: Bone Neoplasms; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; G1 Phase; Gene Expression Regulation; Humans; Osteosarcoma; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; S Phase; Structure-Activity Relationship; Substrate Specificity; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
PhosphoBase, a database of phosphorylation sites: release 2.0.
Topics: Animals; Bacteria; Databases, Factual; Humans; Internet; Kinetics; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Plants; Protein Kinases; Substrate Specificity; Viruses | 1999 |
Phosphorylation-dephosphorylation states at different sites affect phosphoprotein phosphatase 1 activity.
Topics: Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Humans; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Phosphatase 1; src-Family Kinases | 1998 |
Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Down-Regulation; Humans; Isoenzymes; Membranes; Mice; Mitogens; Osmolar Concentration; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Vanadates | 1998 |
Function of WW domains as phosphoserine- or phosphothreonine-binding modules.
Topics: Amino Acid Sequence; Amino Acid Substitution; Calcium-Binding Proteins; cdc25 Phosphatases; Cell Cycle Proteins; Endosomal Sorting Complexes Required for Transport; HeLa Cells; Humans; Ligases; Nedd4 Ubiquitin Protein Ligases; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Signal Transduction; Ubiquitin-Protein Ligases | 1999 |
High-throughput nonradioisotopic detection of picomole levels of phosphothreonine and phosphoserine containing peptides via biotinylation and enzyme-linked immunosorbent assay.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biotinylation; Enzyme-Linked Immunosorbent Assay; Evaluation Studies as Topic; Humans; Microchemistry; Molecular Sequence Data; Mutation; Peptides; Phosphoserine; Phosphothreonine; Tumor Suppressor Protein p53 | 1999 |
Changes in phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in processing of short-term and long-term memories after passive avoidance learning.
Topics: 3T3 Cells; Animals; Animals, Newborn; Avoidance Learning; Binding Sites; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chickens; Color Perception Tests; Cross Reactions; Discrimination Learning; Memory; Memory, Short-Term; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Rats; Recombinant Proteins | 1999 |
Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.
Topics: Acylation; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Mass Spectrometry; Molecular Sequence Data; Palmitates; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Transfection; Trypsin | 1999 |
Temporal activation of the sea urchin late H1 gene requires stage-specific phosphorylation of the embryonic transcription factor SSAP.
Topics: Amino Acid Sequence; Animals; Cyclic AMP-Dependent Protein Kinases; Dimerization; DNA-Binding Proteins; Embryonic Development; Gene Expression Regulation, Developmental; Genes, Reporter; Histones; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; RNA, Messenger; Sea Urchins; Transcription, Genetic; Transcriptional Activation | 1999 |
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Enzyme Activation; Glutathione Transferase; Humans; Isoenzymes; Lipids; Molecular Sequence Data; Peptides; Phosphatidylinositol Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sensitivity and Specificity; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Involvement of protein serine and threonine phosphorylation in human sperm capacitation.
Topics: Antibodies, Monoclonal; Antigens; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunosorbent Techniques; Male; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Zona Pellucida | 1999 |
Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex.
Topics: Amino Acid Sequence; Animals; Calcineurin Inhibitors; Cyclosporine; DNA, Complementary; Humans; Molecular Sequence Data; Mutation; Okadaic Acid; Peptidylprolyl Isomerase; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphothreonine; Plasmodium falciparum; Protozoan Proteins; Sequence Homology, Amino Acid | 1999 |
Inhibitory effect of regucalcin on Ca2+/calmodulin-dependent protein phosphatase activity in rat brain cytosol.
Topics: Animals; Antibodies, Monoclonal; Biomarkers; Brain; Calbindins; Calcineurin; Calcium; Calcium-Binding Proteins; Calmodulin; Carboxylic Ester Hydrolases; Cytosol; Enzyme Activation; Female; Intracellular Signaling Peptides and Proteins; Liver; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Rats, Wistar; S100 Calcium Binding Protein G; S100 Proteins; Sulfotransferases; Trifluoperazine | 1999 |
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Antibody Specificity; bcl-Associated Death Protein; Caenorhabditis elegans Proteins; Carrier Proteins; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Sirolimus; Threonine; Transcription Factors; Wortmannin | 1999 |
Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells.
Topics: Animals; Blotting, Southern; Blotting, Western; Cell Line; DNA Helicases; DNA Replication; Fibroblasts; Flow Cytometry; Mice; Minute Virus of Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Viral Nonstructural Proteins; Virus Replication | 1999 |
Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Enzyme Activation; Fungal Proteins; Gene Expression Regulation, Fungal; Hot Temperature; Humans; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Signal Transduction; Stress, Physiological | 1999 |
Alternative procedure for two-dimensional separation of phosphoamino acids.
Topics: Autoradiography; Chromatography, Thin Layer; Ninhydrin; Nucleotide Mapping; Peptide Mapping; Phosphoamino Acids; Phosphopeptides; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1999 |
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Cell Line; Epitopes; Humans; Isoelectric Point; Nuclear Proteins; Peptide Fragments; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Isoforms; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Recombinant Proteins; Signal Transduction; Spodoptera; Tumor Suppressor Protein p53 | 1999 |
Lyn is activated during late G1 of stem-cell-factor-induced cell cycle progression in haemopoietic cells.
Topics: Aphidicolin; CDC2-CDC28 Kinases; Cell Cycle; Cell Line; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; G1 Phase; Humans; Mimosine; Nocodazole; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Retinoblastoma Protein; src-Family Kinases; Stem Cell Factor; Time Factors | 1999 |
Casein kinase 2 binds and phosphorylates the nucleosome assembly protein-1 (NAP1) in Drosophila melanogaster.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Casein Kinase II; Cell Cycle Proteins; Cell Line; Drosophila melanogaster; Drosophila Proteins; Humans; Insect Proteins; Molecular Weight; Nuclear Proteins; Nucleosome Assembly Protein 1; Peptide Mapping; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Recombinant Fusion Proteins; Sequence Deletion | 1999 |
Signal transduction. Grabbing phosphoproteins.
Topics: 14-3-3 Proteins; Binding Sites; Cell Cycle Proteins; Checkpoint Kinase 2; Fungal Proteins; Humans; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; src Homology Domains; Tyrosine 3-Monooxygenase | 1999 |
Increases in phosphorylation of the myosin II heavy chain, but not regulatory light chains, correlate with insulin secretion in rat pancreatic islets and RINm5F cells.
Topics: Animals; Cells, Cultured; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Myosin Heavy Chains; Myosin Light Chains; Myosin-Light-Chain Kinase; Pancreatic Neoplasms; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Potassium Chloride; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Immunoblotting with antiphosphoamino acid antibodies: importance of the blocking solution.
Topics: Animals; Antibodies; Antibodies, Blocking; Immunoblotting; In Vitro Techniques; Phosphoserine; Phosphothreonine; Rabbits; Solutions | 1999 |
Immunodetection of phosphorylation sites of phospholamban in aortic smooth muscle. Effects of sodium nitroprusside.
Topics: Animals; Aorta; Calcium-Binding Proteins; Cats; Immunoblotting; In Vitro Techniques; Intracellular Membranes; Microsomes; Muscle, Smooth, Vascular; Myocardial Contraction; Nitroprusside; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Sarcoplasmic Reticulum | 1998 |
Binding of select forms of pRB to protein phosphatase type 1 independent of catalytic activity.
Topics: Animals; Catalysis; Cell Line; Chlorocebus aethiops; Chromatography, Affinity; Cloning, Molecular; Enzyme Inhibitors; Microcystins; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Recombinant Fusion Proteins; Recombinant Proteins; Retinoblastoma Protein | 1999 |
Characterization and quantitation of phospholamban and its phosphorylation state using antibodies.
Topics: Animals; Antibodies, Monoclonal; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Cyclic AMP-Dependent Protein Kinases; Dogs; Ferrets; Mice; Myocardium; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Sarcoplasmic Reticulum | 2000 |
Serine/threonine phosphorylation in cellular signaling for alveolar macrophage phagocytic response to endotoxin.
Topics: Animals; Cells, Cultured; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Alveolar; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phagocytosis; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Signal Transduction | 2000 |
Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells.
Topics: Animals; Apoptosis; Catalysis; Cell Differentiation; Cell Division; DNA Replication; Enzyme Activation; Enzyme Induction; Interleukin-3; Isoenzymes; Janus Kinase 2; Macrophages; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Animals, Newborn; Antibodies, Monoclonal; Antibody Specificity; Brain Chemistry; COS Cells; Epitope Mapping; Epitopes; Humans; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; Mutation; Nerve Tissue Proteins; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Plaque, Amyloid; Protein Kinase Inhibitors; Protein Kinases; Rats; Semaphorin-3A; Transfection | 2000 |
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation.
Topics: Animals; beta Catenin; Binding Sites; Cadherins; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Embryo, Mammalian; Endothelium, Vascular; gamma Catenin; Humans; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase C; Recombinant Fusion Proteins; Signal Transduction; Trans-Activators; Umbilical Veins; Yolk Sac | 2000 |
Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser/Thr phosphorylation of the enzyme.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; Conserved Sequence; COS Cells; Cytosol; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phospholipase D; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Recombinant Proteins; Sequence Alignment; Transfection | 2000 |
Identification of calponin as a novel substrate of Rho-kinase.
Topics: Actins; Amino Acid Sequence; Animals; Antibodies; Blotting, Western; Calcium-Binding Proteins; Calponins; Cattle; Chromatography, High Pressure Liquid; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Microfilament Proteins; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Rabbits; Recombinant Fusion Proteins; rho-Associated Kinases | 2000 |
Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Casein Kinase II; Consensus Sequence; Dideoxynucleotides; DNA; DNA Repair; Drug Resistance, Microbial; Enzyme Activation; Foscarnet; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Peptide Mapping; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Proteins; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymine Nucleotides; Zidovudine | 2000 |
Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Topics: Cell Compartmentation; Cell Division; Cell Line; Cell Membrane; Enzyme Activation; Gene Expression; Insulin; Insulin Receptor Substrate Proteins; Lipid Metabolism; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Subcellular Fractions; Tyrosine | 2000 |
Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus.
Topics: Animals; Cell Line; Cell Membrane; Cells, Cultured; Endothelium; Genistein; Goats; Immune Sera; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Protein Serine-Threonine Kinases; Sheep; Staurosporine; Visna-maedi virus | 2000 |
In vivo and in vitro phosphorylation and subcellular localization of trypanosomatid cytoskeletal giant proteins.
Topics: Animals; Antigens, Protozoan; Cell Culture Techniques; Cytoskeletal Proteins; Cytoskeleton; Immunoblotting; Leishmania; Microscopy, Confocal; Microscopy, Immunoelectron; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protozoan Proteins; Trypanosomatina | 2000 |
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Amino Acid Substitution; Animals; Caenorhabditis elegans Proteins; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Enzyme Activation; HSP90 Heat-Shock Proteins; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oncogene Protein p21(ras); Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Rats; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Receptors, Eph Family; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2000 |
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
Topics: Acetylglucosamine; Animals; Cattle; Cells, Cultured; Glycosylation; Hexosamines; Hyperglycemia; Mitochondria; Phosphoserine; Phosphothreonine; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Sp1 Transcription Factor; Superoxides; Transforming Growth Factor beta | 2000 |
Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Casein Kinase II; Cell Line; HeLa Cells; Humans; Membrane Proteins; Mitochondrial Proteins; Mutation; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2 | 2001 |
3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arabidopsis Proteins; CHO Cells; Cricetinae; Enzyme Inhibitors; Insulin; Kinetics; Marine Toxins; Mutation; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Plant Proteins; Potassium Channels; Protein Serine-Threonine Kinases; Transduction, Genetic | 2001 |
Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.
Topics: Animals; Brain; cdc25 Phosphatases; Cell Cycle Proteins; Isomerism; Kinetics; Mutagenesis; Mutagenesis, Site-Directed; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Signal Transduction; Substrate Specificity; Swine; tau Proteins | 2000 |
Functional replacement of the essential ESS1 in yeast by the plant parvulin DlPar13.
Topics: Amino Acid Sequence; Blotting, Western; Cell Nucleus; Cloning, Molecular; Cytosol; Digitalis; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Humans; Kinetics; Molecular Sequence Data; Mutation; Naphthoquinones; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phenotype; Phosphoserine; Phosphothreonine; Plant Proteins; Plants, Medicinal; Plants, Toxic; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Subcellular Fractions; Substrate Specificity; Temperature; Time Factors | 2001 |
Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells.
Topics: Animals; Cell Line; Ceramides; Colon; Enzyme Activation; Epithelial Cells; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha | 2001 |
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Cell Line; Cell Nucleus; DNA-Binding Proteins; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Glutathione Transferase; Green Fluorescent Proteins; Humans; Insulin-Like Growth Factor I; Luminescent Proteins; Mutagenesis, Site-Directed; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Transcription Factors; Transcriptional Activation; Tyrosine 3-Monooxygenase | 2001 |
Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.
Topics: Amino Acid Substitution; Binding Sites; Humans; Ligands; Molecular Mimicry; Mutation; Nuclear Proteins; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.
Topics: Animals; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin A; Cyclin A1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Macromolecular Substances; Male; Mice; Neoplastic Stem Cells; Organ Specificity; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Trans-Activators; Transcription, Genetic; U937 Cells | 2001 |
Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Isomerism; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Protein Conformation; Titrimetry | 2001 |
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Kinetics; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Diprenorphine; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Receptors, Opioid, mu; Recombinant Proteins; Serine; Threonine; Transfection | 2001 |
Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium; Chickens; Enzyme Inhibitors; Gizzard, Avian; Humans; Kinetics; Microcystins; Models, Biological; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Peptide Fragments; Peptides, Cyclic; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2001 |
TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Lymphokines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Stress, Mechanical; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Protein kinase C-mediated desensitization of the neurokinin 1 receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Calcium Signaling; Cell Line; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Indoles; Kidney; Maleimides; Molecular Sequence Data; Mutagenesis, Site-Directed; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Kinase C; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Deletion; Substance P; Transfection | 2001 |
DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells.
Topics: Amino Acid Sequence; Choriocarcinoma; DNA; DNA-Binding Proteins; Down-Regulation; Enhancer Elements, Genetic; Humans; Isoenzymes; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinase C-delta; Protein Structure, Tertiary; Sequence Homology, Amino Acid; TEA Domain Transcription Factors; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation.
Topics: Androstadienes; Animals; Aorta; Bradykinin; Calcineurin Inhibitors; Cattle; Chromones; Cyclosporine; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Kinetics; Morpholines; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Wortmannin | 2001 |
Evidence for phosphoprotein phosphatase in Streptomyces granaticolor.
Topics: Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Streptomyces | 2000 |
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila.
Topics: Amino Acid Sequence; Animals; Base Sequence; Body Patterning; Carrier Proteins; DNA; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; ErbB Receptors; Eye Proteins; Gene Expression Regulation; Genes, Essential; Genes, Reporter; Immunohistochemistry; Insect Proteins; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Nerve Tissue Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Repressor Proteins; Substrate Specificity; Transcription Factors; Two-Hybrid System Techniques | 2001 |
Changes in anti-phosphoserine and anti-phosphothreonine antibody binding during the sleep-waking cycle and after lesions of the locus coeruleus.
Topics: Animals; Antibodies; Cerebral Cortex; Circadian Rhythm; Gene Expression; Hippocampus; Hypothalamus; Locus Coeruleus; Male; Membrane Potentials; Neurons; Oxidopamine; Phosphorylation; Phosphoserine; Phosphothreonine; Polysomnography; Proteins; Rats; Rats, Inbred WKY; Receptors, Adrenergic; Sleep; Sleep Deprivation; Thalamus | 1998 |
Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation.
Topics: Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Death-Associated Protein Kinases; Enzyme Inhibitors; Gene Library; Gizzard, Non-avian; Humans; In Vitro Techniques; Kinetics; Leucine Zippers; Marine Toxins; Mesenteric Arteries; Mice; Microcystins; Molecular Sequence Data; Molecular Weight; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides, Cyclic; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Rabbits; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2001 |
Theoretical models of catalytic domains of protein phosphatases 1 and 2A with Zn2+ and Mn2+ metal dications and putative bioligands in their catalytic centers.
Topics: Animals; Binding Sites; Catalysis; Catalytic Domain; Cations; Computer Simulation; Ligands; Magnesium; Models, Molecular; Phosphates; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Protein Binding; Protein Phosphatase 1; Protein Structure, Tertiary; Time Factors; Zinc | 2001 |
Multiple phosphorylation of membrane-associated calcium-dependent protein serine/threonine kinase in Streptomyces fradiae.
Topics: Autoradiography; Calcium; Cell-Free System; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Denaturation; Protein Serine-Threonine Kinases; Streptomyces | 2001 |
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.
Topics: Animals; Calcium Channels; Casein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Receptors, Metabotropic Glutamate | 2001 |
Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: II. Mutational analysis.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cyclic AMP-Dependent Protein Kinases; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Rats; Structure-Activity Relationship | 2001 |
Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS).
Topics: 3T3 Cells; Animals; Crk-Associated Substrate Protein; Enzyme Inhibitors; Mice; Microcystins; Mutation; Okadaic Acid; Oncogene Protein pp60(v-src); Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Phosphatase 2; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Temperature | 2001 |
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
Topics: Animals; Aorta; Arginine; Calcium Signaling; Cells, Cultured; Chromones; Citrulline; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Quinazolines; Signal Transduction; Swine; Tyrphostins | 2002 |
Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase.
Topics: Apoenzymes; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 2; Deoxyribodipyrimidine Photo-Lyase; DNA Damage; Fungal Proteins; Genes, Fungal; Histone Demethylases; Membrane Glycoproteins; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2002 |
Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry.
Topics: Animals; Humans; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling; Sulfhydryl Compounds | 2001 |
The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; Adipocytes; Animals; Cells, Cultured; Chelating Agents; Glucose; Glucose Transporter Type 4; Heat-Shock Response; Insulin; Intracellular Fluid; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2002 |
Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucosamine; Glucose; Glucose Transporter Type 4; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt | 2002 |
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinase Kinases; Animals; Cell Line; Drosophila; Embryo, Mammalian; Embryo, Nonmammalian; Humans; Kidney; Molecular Sequence Data; Peptide Mapping; Peutz-Jeghers Syndrome; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 2002 |
Effect of phosphorylation on the structure and fold of transactivation domain of p53.
Topics: Amino Acid Sequence; Circular Dichroism; Humans; Kinetics; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Folding; Recombinant Proteins; Transcriptional Activation; Tumor Suppressor Protein p53 | 2002 |
Phosphopeptide detection and sequencing by matrix-assisted laser desorption/ionization quadrupole time-of-flight tandem mass spectrometry.
Topics: Amino Acid Sequence; Animals; Caseins; Cattle; Chromatography, Affinity; Molecular Sequence Data; Ovalbumin; Phosphopeptides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Biological Transport; Cell Nucleus; COS Cells; Cytoplasm; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescent Antibody Technique; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Microscopy, Confocal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2002 |
Isolation of a cDNA for a nucleoside diphosphate kinase capable of phosphorylating the kinase domain of the self-incompatibility factor SRK of Brassica campestris.
Topics: Amino Acid Sequence; Brassica; DNA, Complementary; Molecular Sequence Data; Nucleoside-Diphosphate Kinase; Phosphorylation; Phosphoserine; Phosphothreonine; Plant Proteins; Protein Kinases; Sequence Homology, Amino Acid; Signal Transduction | 2002 |
Store depletion-induced calcium influx in rat cerebellar astrocytes.
Topics: Animals; Astrocytes; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Intracellular Fluid; Membrane Potentials; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley | 2002 |
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Apoptosis; Celecoxib; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Sulfonamides; Tumor Cells, Cultured | 2002 |
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Glucose; Insulin; Insulin Antagonists; Insulin Resistance; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Time Factors | 2002 |
PrpE, a PPP protein phosphatase from Bacillus subtilis with unusual substrate specificity.
Topics: Acid Anhydride Hydrolases; Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Catalysis; Cloning, Molecular; Escherichia coli; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 2002 |
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
Topics: 3T3 Cells; Adult; Animals; Blood Physiological Phenomena; Cell Cycle; Cell Cycle Proteins; Cell Nucleus; Cells, Cultured; Chromosomes, Human, Pair 1; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Growth Substances; Humans; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; RNA, Small Interfering; RNA, Untranslated; Tumor Suppressor Proteins | 2002 |
Rum1, an inhibitor of cyclin-dependent kinase in fission yeast, is negatively regulated by mitogen-activated protein kinase-mediated phosphorylation at Ser and Thr residues.
Topics: Amino Acid Substitution; Animals; CDC2 Protein Kinase; Cell Cycle; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Starfish | 2002 |
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Binding Sites; Cattle; Cell Line; Cell Membrane; Dimerization; Enzyme Activation; Enzyme Inhibitors; Humans; Insulin-Like Growth Factor I; Kidney; Membrane Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Interaction Mapping; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Recombinant Fusion Proteins; Sirolimus; Tacrolimus Binding Protein 1A; Tamoxifen; TOR Serine-Threonine Kinases; Transfection | 2002 |
Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, via electrophilic fluorination of lithiated bis-lactim ethers.
Topics: Crystallography, X-Ray; Ethers; Fluorine; Indicators and Reagents; Lactams; Organophosphonates; Phosphoserine; Phosphothreonine; Stereoisomerism | 2002 |
General method for the synthesis of caged phosphopeptides: tools for the exploration of signal transduction pathways.
Topics: Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Photolysis; Signal Transduction | 2002 |
Protein serine and threonine phosphorylation, hyperactivation and acrosome reaction in in vitro capacitated hamster spermatozoa.
Topics: Acrosome Reaction; Animals; Calcium; Cattle; Cells, Cultured; Cricetinae; Culture Media; Fluorescent Antibody Technique, Indirect; Male; Mesocricetus; Molecular Weight; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Serum Albumin, Bovine; Sodium Bicarbonate; Sperm Capacitation | 2002 |
A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate.
Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell Line; Contractile Proteins; Enzyme Inhibitors; Filamins; Humans; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; Oxazoles; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Enzyme Activation; Growth Substances; Humans; Hydrophobic and Hydrophilic Interactions; Immediate-Early Proteins; In Vitro Techniques; Mice; Models, Molecular; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Homology, Amino Acid; Signal Transduction | 2002 |
Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A.
Topics: 3T3 Cells; Amino Acid Sequence; Amino Acid Substitution; Anaphase-Promoting Complex-Cyclosome; Animals; Aurora Kinase A; Aurora Kinases; Cell Cycle Proteins; Cell Transformation, Neoplastic; Egg Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Ligases; Mice; Mice, Nude; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Neoplasm Transplantation; Neoplasms, Experimental; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Species Specificity; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Xenopus laevis; Xenopus Proteins | 2002 |
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Cell Differentiation; CHO Cells; Cricetinae; Curcumin; DNA; Enzyme Inhibitors; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Insulin; Mice; Microscopy, Fluorescence; Monosaccharide Transport Proteins; Muscle Proteins; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Transfection | 2002 |
Identification of phosphoserine and phosphothreonine as cysteic acid and beta-methylcysteic acid residues in peptides by tandem mass spectrometric sequencing.
Topics: Amino Acid Sequence; Amino Acids; Caseins; Cysteic Acid; Indicators and Reagents; Mass Spectrometry; Peptides; Phosphoserine; Phosphothreonine; Protein Hydrolysates; Protein Kinases; Sequence Analysis; Trypsin | 2002 |
Decorin affects endothelial cells by Akt-dependent and -independent pathways.
Topics: Animals; Cell Line; Decorin; Endothelium, Vascular; Extracellular Matrix Proteins; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Transforming Growth Factor beta | 2002 |
PBX1 nuclear export is regulated independently of PBX-MEINOX interaction by PKA phosphorylation of the PBC-B domain.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Humans; Isoelectric Focusing; Kinetics; Leucine; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Pre-B-Cell Leukemia Transcription Factor 1; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction | 2003 |
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Topics: Amino Acid Motifs; Binding Sites; Calorimetry; cdc25 Phosphatases; Cell Cycle Proteins; Centrosome; HeLa Cells; Humans; Ligands; Mitosis; Peptide Library; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Polo-Like Kinase 1; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteomics; Proto-Oncogene Proteins; Signal Transduction | 2003 |
Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Antigens, CD; Carrier Proteins; Cytokine Receptor gp130; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Immunoblotting; Indoles; Janus Kinase 2; Maleimides; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction; Transfection; Ubiquitin-Protein Ligases | 2003 |
An experimental and theoretical study of the 13C and 31P chemical shielding tensors in solid O-phosphorylated amino acids.
Topics: Amino Acids; Carbon Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphorus; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Stereoisomerism | 2003 |
A new approach to phosphoserine and phosphothreonine analysis in peptides and proteins: chemical modification, enrichment via solid-phase reversible binding, and analysis by mass spectrometry.
Topics: Amino Acid Sequence; Mass Spectrometry; Molecular Sequence Data; Peptides; Phosphoserine; Phosphothreonine; Proteins | 2003 |
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Cell Line; Mass Spectrometry; Multienzyme Complexes; Mutagenesis, Site-Directed; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Recombinant Proteins; Structure-Activity Relationship; Transfection | 2003 |
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
Topics: 14-3-3 Proteins; 3T3 Cells; Amino Acid Motifs; Animals; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Genetic Vectors; Glutathione Transferase; Humans; Ligands; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphorylation; Phosphoserine; Phosphothreonine; Plasmids; Precipitin Tests; Prolactin; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Prolactin; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Threonine; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
CRP: Cleavage of Radiolabeled Phosphoproteins.
Topics: Humans; Internet; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Radioactive Tracers; Sequence Analysis, Protein; Software | 2003 |
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T.
Topics: Actomyosin; Amino Acid Sequence; Amino Acid Substitution; Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Cloning, Molecular; Glutamic Acid; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardial Contraction; Myocardium; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Structure, Secondary; Recombinant Proteins; Troponin T; Ventricular Function, Left | 2003 |
Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants.
Topics: Animals; Blotting, Western; Carcinoma, Lewis Lung; Cytoskeletal Proteins; Down-Regulation; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Okadaic Acid; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Precipitin Tests; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tumor Cells, Cultured | 2003 |
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.
Topics: Aging; Alzheimer Disease; Amino Acid Motifs; Animals; Behavior, Animal; Gene Deletion; Gene Expression; Humans; Mice; Mice, Knockout; Microscopy, Electron; Motor Activity; Neurofibrillary Tangles; Neurons; Neuroprotective Agents; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Plaque, Amyloid; Tauopathies | 2003 |
Phosphospecific proteolysis for mapping sites of protein phosphorylation.
Topics: beta-Adrenergic Receptor Kinases; Cyclic AMP-Dependent Protein Kinases; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Peptide Hydrolases; Phosphoamino Acids; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Protein Interaction Mapping; Proteome; Proteomics; Tubulin | 2003 |
Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenases.
Topics: Amino Acid Sequence; Bacillus subtilis; Base Sequence; Conserved Sequence; DNA Primers; Enzyme Activation; Kinetics; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Uridine Diphosphate Glucose Dehydrogenase | 2003 |
[Syntheses in the vitamin B12 group. IX. On the synthesis of cobyrinyl-abcdeg-hexamide-f-N-DL-serine phosphate and cobyrinyl-abcdeg-f-N-DL-threonine phosphate and the biosynthetic evaluation of some cobinamide analogs].
Topics: Amino Acids; Cobamides; Corrinoids; Phosphates; Phosphoserine; Phosphothreonine; Vitamin B 12 | 1962 |
Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence.
Topics: Animals; Binding Sites; Cell Line; Cysteine; Dose-Response Relationship, Drug; HeLa Cells; Humans; Hydrogen Peroxide; Immunoblotting; Macrophages; Mice; Mitochondria; Oxygen; Peptides; Peroxidases; Peroxiredoxins; Phosphoserine; Phosphothreonine; Proteins; Sensitivity and Specificity; Sulfinic Acids; Time Factors | 2003 |
BRCT repeats as phosphopeptide-binding modules involved in protein targeting.
Topics: Amino Acid Motifs; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Caffeine; Calorimetry; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Cytosol; DNA Damage; DNA-Binding Proteins; Gamma Rays; Humans; Nuclear Proteins; Peptide Library; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteomics; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Influence of immobilization stress on the expression and phosphatase activity of protein phosphatase 2A in the rat brain.
Topics: Animals; Catalytic Domain; Frontal Lobe; Hippocampus; Immobilization; Immunoblotting; Immunohistochemistry; Male; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Stress, Physiological; Time Factors | 2003 |
Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro.
Topics: Alzheimer Disease; Amino Acid Sequence; Biomarkers; Cloning, Molecular; Consensus Sequence; Escherichia coli; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Kinetics; Nerve Degeneration; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Substrate Specificity; tau Proteins | 2003 |
Improved beta-elimination-based affinity purification strategy for enrichment of phosphopeptides.
Topics: Animals; Cattle; Chromatography, Affinity; Disulfides; Mass Spectrometry; Peptides; Phosphopeptides; Phosphoserine; Phosphothreonine; Proteins | 2003 |
Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.
Topics: Animals; Brain; Enzyme Inhibitors; Glycogen Synthase; Glycogen Synthase Kinases; Humans; Imidazoles; Isoenzymes; Liver; Mice; Mitogen-Activated Protein Kinases; Muscle Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Organ Specificity; Osmotic Pressure; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Pyridines; Rabbits; Recombinant Fusion Proteins; Substrate Specificity | 2004 |
Phosphoprotein isotope-coded solid-phase tag approach for enrichment and quantitative analysis of phosphopeptides from complex mixtures.
Topics: Amino Acid Sequence; Carbon Isotopes; Caseins; Cell Extracts; Cell Line, Tumor; Complex Mixtures; Databases, Protein; Gas Chromatography-Mass Spectrometry; Glass; Humans; Isotope Labeling; Molecular Sequence Data; Molecular Weight; Nitrogen Isotopes; Peptide Fragments; Phosphopeptides; Phosphoproteins; Phosphoserine; Phosphothreonine; Photochemistry; Trypsin | 2003 |
Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
Topics: Animals; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Enzyme Inhibitors; Lymphoma, B-Cell; Marine Toxins; Mice; Oxazoles; Peptide Fragments; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Proteomics; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.
Topics: Amino Acid Sequence; Animals; Benzamides; Cell Line; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; SAP90-PSD95 Associated Proteins; Stress, Physiological; Ultraviolet Rays | 2004 |
The charged milieu: a major player in fertilization reactions.
Topics: Amino Acids; Animals; Arginine; Calcimycin; Calcium; Female; Fertilization; Glucosamine; Glucose-6-Phosphate; Hexosephosphates; Hydrogen-Ion Concentration; Male; Monosaccharides; Phosphoserine; Phosphothreonine; Ribosemonophosphates; Sea Urchins; Seawater; Sperm Motility; Sugar Phosphates; Zinc | 2004 |
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle.
Topics: Acetylglucosamine; Animals; Biological Transport; Glucose; Glycosylation; Insulin; Insulin Resistance; Kinetics; Male; Muscle Proteins; Muscle, Skeletal; Oximes; Phenylcarbamates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Rats; Rats, Wistar | 2004 |
Master of all things phosphorylated.
Topics: 14-3-3 Proteins; Binding Sites; Chromatography, Affinity; Humans; Ligands; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Tyrosine 3-Monooxygenase | 2004 |
Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation.
Topics: Animals; Benzoquinones; Calcineurin; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Genetic Therapy; Genetic Vectors; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Liposomes; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Sus scrofa; Transfection; Umbilical Veins; Vascular Endothelial Growth Factor A | 2004 |
Parathyroid-hormone-related protein as a regulator of pRb and the cell cycle in arterial smooth muscle.
Topics: Adenoviridae; Angioplasty, Balloon; Animals; Aorta, Thoracic; Carotid Artery Injuries; Carotid Artery, Common; Cell Cycle; Cell Division; Cell Line; DNA, Complementary; Genetic Therapy; Genetic Vectors; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Transport; Rats; Rats, Sprague-Dawley; Retinoblastoma Protein; Transfection | 2004 |
Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment.
Topics: Animals; Caspase 3; Caspases; Cell Line; Cell Survival; Cyclic AMP; Enzyme Activation; Humans; Immunoblotting; Immunohistochemistry; Mice; Neurites; Neuroblastoma; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; tau Proteins; Time Factors; Tubulin | 2004 |
Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats.
Topics: Animals; Animals, Genetically Modified; Blotting, Western; Calcium; Calcium Chloride; Calcium-Binding Proteins; Calmodulin; Carboxylic Ester Hydrolases; Chelating Agents; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Gene Dosage; Intracellular Signaling Peptides and Proteins; Male; Microsomes, Liver; Okadaic Acid; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfotransferases; Trifluoperazine; Vanadates | 2004 |
Characterization of dynamic and steady-state protein phosphorylation using a fluorescent phosphoprotein gel stain and mass spectrometry.
Topics: Animals; Cattle; Electron Transport Complex I; Female; Fluorescent Dyes; HeLa Cells; Humans; Mitochondria, Heart; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Subunits; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Mitogen-activated protein kinases mediate the oxidative burst and saponin synthesis induced by chitosan in cell cultures of Panax ginseng.
Topics: Cell Line; Chitosan; Enzyme Inhibitors; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Molecular Weight; NADPH Oxidases; Oxidation-Reduction; Panax; Phosphoserine; Phosphothreonine; Plant Proteins; Respiratory Burst; Saponins; Transcription, Genetic | 2004 |
Regulation of plant symbiosis receptor kinase through serine and threonine phosphorylation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cattle; Cloning, Molecular; DNA Primers; Escherichia coli; Fabaceae; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphoserine; Phosphothreonine; Pisum sativum; Plant Proteins; Polymerase Chain Reaction; Protein Conformation; Protein Kinases; Protein Structure, Secondary; Receptors, Cell Surface; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2005 |
Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p27; Cytosol; G1 Phase; Humans; Mice; Models, Biological; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Time Factors; Tumor Suppressor Proteins | 2005 |
Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.
Topics: Adrenergic beta-Agonists; Amino Acid Substitution; Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Enzyme Activation; Insulin Resistance; Isoproterenol; Mice; Mice, Transgenic; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor Cross-Talk; Receptor, Insulin; Receptors, Adrenergic, beta; Signal Transduction; Structure-Activity Relationship; Sympathetic Nervous System | 2005 |
Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation.
Topics: Amino Acid Sequence; Cell Line; DNA Primers; HeLa Cells; Humans; Kidney; MAP Kinase Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2005 |
p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.
Topics: Acetylation; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; Down-Regulation; Humans; Lysine; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Promoter Regions, Genetic; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53 | 2005 |
Another role for the celebrity: Akt and insulin resistance.
Topics: Adrenergic beta-Agonists; Animals; Deoxyglucose; Enzyme Activation; Humans; Insulin Resistance; Isoproterenol; MAP Kinase Signaling System; Mice; Models, Biological; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor Cross-Talk; Receptor, Insulin; Receptors, Adrenergic, beta; Signal Transduction; Structure-Activity Relationship | 2005 |
Novel phosphorylation of histone H3 at threonine 11 that temporally correlates with condensation of mitotic and meiotic chromosomes in plant cells.
Topics: Arabidopsis; Chromosomes, Plant; Heterochromatin; Histones; Hordeum; Immunohistochemistry; Meiosis; Microscopy, Electron; Mitosis; Phosphorylation; Phosphoserine; Phosphothreonine; Plant Proteins; Secale; Threonine; Vicia faba | 2005 |
Rapid enrichment and analysis of yeast phosphoproteins using affinity chromatography, 2D-PAGE and peptide mass fingerprinting.
Topics: Alkaline Phosphatase; Blotting, Western; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sorbic Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage.
Topics: Amino Acid Sequence; DNA Damage; DNA Replication; DNA-Binding Proteins; HeLa Cells; Humans; Hydroxyurea; Molecular Sequence Data; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Subunits; Replication Protein A; Trypsin; Ultraviolet Rays | 2005 |
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cricetinae; DNA Primers; Genes, Reporter; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Kidney; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Serine | 2005 |
Phosphoproteomic analysis with a solid-phase capture-release-tag approach.
Topics: Amino Acid Sequence; Binding Sites; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteamine; Isotope Labeling; Microtubule-Associated Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Proteomics; tau Proteins | 2005 |
Method development and measurements of endogenous serine/threonine Akt phosphorylation using capillary electrophoresis for systems biology.
Topics: Animals; Electrophoresis, Capillary; Enzyme Activation; PC12 Cells; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Substrate Specificity; Threonine; Ultraviolet Rays | 2005 |
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo.
Topics: Animals; Brain; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Hyperinsulinism; Insulin; Mice; Mice, Inbred C57BL; Phosphorylation; Phosphoserine; Phosphothreonine; Receptor, Insulin; Signal Transduction; tau Proteins | 2005 |
Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Caseins; Cyclic Nucleotide Phosphodiesterases, Type 3; Immunoprecipitation; Male; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.
Topics: Animals; Binding Sites; Cells, Cultured; Cricetinae; Heat-Shock Proteins; Humans; Mice; Neurons; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; tau Proteins | 2006 |
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
Topics: Amino Acid Sequence; Apoptosis; Binding Sites; Cell Line, Tumor; Doxorubicin; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt | 2006 |
AKT can be activated in the nucleus.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; Cytoplasm; Enzyme Activation; HeLa Cells; Humans; Nuclear Export Signals; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Tumor Cells, Cultured | 2006 |
Hyperphosphorylation of tau induces local polyproline II helix.
Topics: Amino Acid Sequence; Circular Dichroism; Humans; Molecular Sequence Data; Neurofibrillary Tangles; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Conformation; Protein Structure, Secondary; tau Proteins | 2006 |
Subcellular localization and functions of the barley stem rust resistance receptor-like serine/threonine-specific protein kinase Rpg1.
Topics: Amino Acid Sequence; Calcium; Catalysis; Cations, Divalent; Cell Membrane; Cytoplasm; Hordeum; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoserine; Phosphothreonine; Plant Diseases; Plant Proteins; Plant Stems; Plants, Genetically Modified; Protein Serine-Threonine Kinases | 2006 |
Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Binding Sites; Biomarkers; Cattle; Epitopes; Humans; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; tau Proteins | 2006 |
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
Topics: Amino Acid Sequence; Catalytic Domain; Enzyme Activation; Humans; Interleukin-1; MAP Kinase Kinase Kinases; Mass Spectrometry; Molecular Sequence Data; Mutation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins | 2006 |
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Fatty Acids, Unsaturated; G1 Phase; Humans; Mutation; Phosphoserine; Phosphothreonine; Recombinant Proteins; Resting Phase, Cell Cycle; Staurosporine | 2006 |
Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; DNA, Neoplasm; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Histones; Humans; Models, Biological; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Receptor, ErbB-2; Retinoblastoma Protein; RNA, Messenger; Trastuzumab; Tumor Cells, Cultured | 2006 |
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase.
Topics: Adenosine Triphosphatases; Ataxia Telangiectasia Mutated Proteins; CDC2 Protein Kinase; Cell Cycle Proteins; DNA Helicases; DNA-Binding Proteins; HeLa Cells; Humans; Mitosis; Models, Genetic; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; RecQ Helicases; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2006 |
Graded regulation of the Kv2.1 potassium channel by variable phosphorylation.
Topics: Alanine; Alkaline Phosphatase; Animals; Aspartic Acid; Brain; Calcineurin; Calcium; Cell Line; Chromatography, Liquid; Humans; Ion Channel Gating; Ionomycin; Mass Spectrometry; Mutation; Neurons; Patch-Clamp Techniques; Phosphorylation; Phosphoserine; Phosphothreonine; Point Mutation; Rats; Recombinant Proteins; Serine; Shab Potassium Channels; Transfection | 2006 |
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Humans; Phospholipase D; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Proto-Oncogene Proteins c-myc | 2006 |
Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.
Topics: Cell Line; E2F1 Transcription Factor; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Phosphoserine; Phosphothreonine; Protein Binding; RNA, Small Interfering; Trans-Activators | 2007 |
Approach to systematic analysis of serine/threonine phosphoproteome using Beta elimination and subsequent side effects: intramolecular linkage and/or racemisation.
Topics: Amino Acid Sequence; Computational Biology; Databases, Factual; Molecular Structure; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Proteomics; Serine; Stereoisomerism | 2007 |
A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor.
Topics: Cell Line; Enzyme Inhibitors; Genome, Human; Humans; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphoric Triester Hydrolases; Phosphoserine; Phosphothreonine; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2007 |
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.
Topics: Animals; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Heart; Muscle Cells; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Ryanodine Receptor Calcium Release Channel; Time Factors | 2007 |
C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
Topics: Apoptosis; Cell Line, Tumor; Humans; Immunoprecipitation; Interferon-alpha; Lung Neoplasms; Oncogene Proteins; Peptide Elongation Factor 1; Phosphorylation; Phosphoserine; Phosphothreonine; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-raf; RNA, Small Interfering; Ubiquitin | 2007 |
Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle.
Topics: Adult; Biopsy; Blood Glucose; Female; Glucose Clamp Technique; Glucose Tolerance Test; Homeostasis; Humans; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Male; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Reference Values | 2007 |
A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.
Topics: Animals; F-Box Proteins; MAP Kinase Signaling System; Meiosis; Mitogen-Activated Protein Kinases; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-mos; Ribosomal Protein S6 Kinases, 90-kDa; Xenopus laevis; Xenopus Proteins | 2007 |
Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Luteolin; Mice; Mice, Nude; Mitochondria; Phosphorylation; Phosphoserine; Phosphothreonine; Proteasome Endopeptidase Complex; Protein Transport; Thermodynamics; Tumor Suppressor Protein p53; Ubiquitin | 2007 |
A multiplexed protein kinase assay.
Topics: Cell Extracts; DNA; Enzyme Activation; HeLa Cells; Humans; Isotope Labeling; Molecular Probe Techniques; Oligonucleotides; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Sensitivity and Specificity; Solutions; Substrate Specificity | 2007 |
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function.
Topics: Amino Acid Sequence; Animals; Aurora Kinases; Cell Cycle; Cell Extracts; Centromere; Chromatin; Kinesins; Models, Biological; Molecular Sequence Data; Mutant Proteins; Ovum; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Spindle Apparatus; Substrate Specificity; Time Factors; Xenopus laevis; Xenopus Proteins | 2007 |
Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Conserved Sequence; Gene Expression Regulation; Humans; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Sequence Alignment; Substrate Specificity; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitin-Protein Ligases | 2007 |
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Topics: AMP-Activated Protein Kinases; Animals; Cell Respiration; Cytochromes c; Female; Gene Expression Regulation; Glucose Transporter Type 4; Mice; Mitochondria; Multienzyme Complexes; Muscle, Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Phosphoserine; Phosphothreonine; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Trans-Activators; Transcription Factors | 2007 |
Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Hemidesmosomes; Humans; Integrin beta4; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Plectin; Protein Kinase C; Protein Structure, Tertiary; Protein Subunits | 2007 |
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.
Topics: Adult; Aged; Esophageal Neoplasms; Female; Human papillomavirus 16; Humans; Immunohistochemistry; Male; Middle Aged; Papillomavirus Infections; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Uterine Cervical Neoplasms | 2007 |
Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells.
Topics: Amino Acid Sequence; Animals; Cattle; Cells, Cultured; Chlorocebus aethiops; COS Cells; Drosophila; Endothelial Cells; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Molecular Sequence Data; Myosin-Light-Chain Phosphatase; Nitric Oxide Synthase Type III; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Thrombin; Time Factors; Umbilical Veins | 2007 |
UDP-acetyl-mannosamine dehydrogenase is an endogenous protein substrate of Staphylococcus aureus protein-tyrosine kinase activity.
Topics: Amino Acid Sequence; Bacterial Proteins; Carbohydrate Dehydrogenases; Electrophoresis; Isoenzymes; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Staphylococcus aureus; Substrate Specificity | 2007 |
Fibrous and helical calcite crystals induced by synthetic polypeptides containing o-phospho-L-serine and o-phospho-L-threonine.
Topics: Calcium Carbonate; Crystallization; Microscopy, Electron; Peptides; Phosphoserine; Phosphothreonine; X-Ray Diffraction | 2008 |
Proteomic approach for caudal trauma-induced acute phase proteins reveals that creatine kinase is a key acute phase protein in amphioxus humoral fluid.
Topics: Acute-Phase Proteins; Animals; Antibodies, Monoclonal; Chordata; Cloning, Molecular; Creatine Kinase; Gene Expression Regulation; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteomics; Spectrometry, Mass, Electrospray Ionization; Time Factors; Wound Healing | 2007 |
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.
Topics: 14-3-3 Proteins; A Kinase Anchor Proteins; Actinin; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Animals; Binding, Competitive; Calcineurin; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Enzyme Activation; Humans; Mice; Microfilament Proteins; Muscle Proteins; Myoblasts; Myocytes, Cardiac; Nuclear Proteins; Phosphoserine; Phosphothreonine; Protein Binding; Protein Transport; Rats; Signal Transduction | 2007 |
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Caspase 3; Cells, Cultured; DNA; Gene Expression Regulation, Enzymologic; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mutation; Phosphoserine; Phosphothreonine; Rats; Rats, Wistar; Transforming Growth Factor beta | 2008 |
Phosphopeptide elution times in reversed-phase liquid chromatography.
Topics: Amino Acid Sequence; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Peptide Fragments; Peptides; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Predictive Value of Tests; Proteome; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors; Trifluoroacetic Acid; Trypsin | 2007 |
Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells.
Topics: Animals; Cell Cycle; Cell Nucleus; Chromatin; Enzyme Activation; Gene Expression; HeLa Cells; Histones; Humans; Mammals; Mice; Mitosis; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Rats | 2007 |
Phospho.ELM: a database of phosphorylation sites--update 2008.
Topics: Databases, Protein; Internet; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Sequence Alignment; Sequence Analysis, Protein; Software | 2008 |
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA-Binding Proteins; Humans; Mutation; Neoplasms; Phosphoserine; Phosphothreonine; Protein Binding; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.
Topics: Animals; Biological Transport; Carrier Proteins; Gene Expression Regulation; Glucose; Glycogen; Glycogen Synthase; GTPase-Activating Proteins; Insulin; Male; Mice; Mice, Knockout; Muscles; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein | 2008 |
DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.
Topics: AIRE Protein; Amino Acid Motifs; Antigens, Nuclear; Cell Line; DNA-Activated Protein Kinase; DNA-Binding Proteins; Epithelial Cells; Humans; Ku Autoantigen; Mass Spectrometry; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Transcription Factors; Transcriptional Activation | 2008 |
GSK-3-mediated phosphorylation enhances Maf-transforming activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Chickens; Chlorocebus aethiops; COS Cells; Glycogen Synthase Kinase 3; Humans; Maf Transcription Factors, Large; Molecular Sequence Data; p300-CBP Transcription Factors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Rats; Transcription, Genetic; Ubiquitination | 2007 |
Site specific phosphorylation of yeast RNA polymerase I.
Topics: Amino Acid Sequence; Fungal Proteins; Models, Molecular; Molecular Sequence Data; Mutation; Phenotype; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; RNA Polymerase I; Yeasts | 2008 |
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Topics: Animals; beta-Transducin Repeat-Containing Proteins; cdc25 Phosphatases; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Activation; Enzyme Stability; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Models, Biological; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Kinases; Protein Processing, Post-Translational; Radiation, Ionizing; Ubiquitin | 2008 |
Mechanistic insights into the multistage gas-phase fragmentation behavior of phosphoserine- and phosphothreonine-containing peptides.
Topics: Deuterium; Gases; Phase Transition; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.
Topics: Adult; Diabetes Mellitus, Type 2; Enzyme Activation; Female; Humans; Insulin; Isoenzymes; Male; Middle Aged; Muscle, Skeletal; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; Reference Values; RNA, Messenger | 2008 |
Meta-prediction of phosphorylation sites with weighted voting and restricted grid search parameter selection.
Topics: Internet; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Sequence Analysis, Protein; Software | 2008 |
TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism.
Topics: Animals; Apoptosis; Benzamides; Caseins; Cells, Cultured; Dioxoles; Epithelial Cells; Gene Expression Regulation; Genes, Dominant; Humans; Janus Kinase 2; Mammary Glands, Animal; Phosphoserine; Phosphothreonine; Phosphotyrosine; Prolactin; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Smad3 Protein; STAT5 Transcription Factor; Transforming Growth Factor beta | 2008 |
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.
Topics: 14-3-3 Proteins; AMP-Activated Protein Kinases; Animals; Chlorocebus aethiops; COS Cells; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Humans; Indoles; Mice; Oximes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Rats | 2008 |
Polo-box domains confer target specificity to the Polo-like kinase family.
Topics: Bone Neoplasms; cdc25 Phosphatases; Cell Cycle Proteins; Centrosome; Humans; Mitosis; Osteosarcoma; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Recombinant Proteins; Spindle Apparatus; Substrate Specificity; Surface Plasmon Resonance; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2008 |
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Topics: Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Conserved Sequence; Humans; Kinetics; Mice; Molecular Sequence Data; Mutation; Myosin Heavy Chains; Nonmuscle Myosin Type IIA; Phosphorylation; Phosphoserine; Phosphothreonine; Sequence Alignment; TRPM Cation Channels | 2008 |
Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry.
Topics: Amino Acid Sequence; Electrons; Humans; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Myocardium; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Isoforms; Troponin I | 2008 |
Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arabidopsis; Conserved Sequence; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Plant Proteins; Protein Structure, Tertiary; Proteome; Sequence Homology, Amino Acid | 2008 |
Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cattle; Cells, Cultured; Endothelial Cells; Enzyme Activation; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Nitric Oxide Synthase Type III; Phosphoserine; Phosphothreonine; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Reactive Nitrogen Species; RNA, Small Interfering | 2008 |
Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity.
Topics: Cell Adhesion; Cell Line; Cell Proliferation; Collagen; Enzyme Activation; Fibroblasts; Humans; Integrin beta1; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Protein Binding; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2008 |
Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex.
Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Consensus Sequence; Cyclin-Dependent Kinase 2; DNA-Binding Proteins; Humans; Mice; Minichromosome Maintenance Complex Component 3; Multiprotein Complexes; NIH 3T3 Cells; Nuclear Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Substrate Specificity | 2008 |
Phosphorylation and kinetics of mammalian cytochrome c oxidase.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Cattle; Electron Transport Complex IV; Kinetics; Mitochondria, Heart; Myocardium; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine | 2008 |
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; Etoposide; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indazoles; Indoles; Leukemia-Lymphoma, Adult T-Cell; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt | 2008 |
A wide-ranging cellular response to UV damage of DNA.
Topics: DNA Damage; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Proteins; Ultraviolet Rays | 2008 |
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction.
Topics: Fluorescence; Fluorescent Dyes; Kinetics; Peptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Array Analysis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2008 |
The role of phosphorylated residues in peptide-peptide noncovalent complexes formation.
Topics: Arginine; Peptides; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Static Electricity | 2008 |
Temperature sensitivity of phospho-Ser(473)-PKB/AKT.
Topics: Animals; Cell Line; Down-Regulation; Hot Temperature; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase | 2008 |
Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase.
Topics: Altitude; Animals; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Fetus; Hypoxia; In Vitro Techniques; Models, Biological; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Phosphoserine; Phosphothreonine; Pulmonary Veins; rho-Associated Kinases; Sheep; Vasodilation | 2008 |
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.
Topics: Amino Acid Motifs; Amino Acid Sequence; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cisplatin; Cyclin-Dependent Kinase 2; DNA Damage; DNA-Binding Proteins; Head and Neck Neoplasms; Humans; Molecular Sequence Data; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins | 2008 |
Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism.
Topics: Adenine Phosphoribosyltransferase; Adiponectin; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Fructose; Glucose; Leptin; Liver; Liver Neoplasms; Male; Phosphoproteins; Phosphoserine; Phosphothreonine; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2008 |
Detection and assignment of phosphoserine and phosphothreonine residues by (13)C- (31)P spin-echo difference NMR spectroscopy.
Topics: Carbon Isotopes; Escherichia coli; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphoproteins; Phosphorus Isotopes; Phosphoserine; Phosphothreonine; Proteins; Proto-Oncogene Protein c-ets-1 | 2009 |
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.
Topics: Animals; Cell Cycle; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; Neurons; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Phosphatase 2; Protein Subunits; Rats; Receptor, trkA | 2009 |
The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms.
Topics: 4-Butyrolactone; beta Catenin; Caco-2 Cells; Cadherins; Cytoplasm; Epithelial Cells; Genistein; Homoserine; Humans; Intercellular Junctions; Membrane Proteins; Occludin; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Pseudomonas aeruginosa; Quorum Sensing; Staurosporine; Zonula Occludens-1 Protein | 2009 |
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.
Topics: Amino Acid Sequence; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Cell Cycle; Enzyme Activation; Fatty Acids; G1 Phase; Homeostasis; Lipase; Lipids; Lipolysis; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Triglycerides | 2009 |
Functional involvement of protein kinase C-betaII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells.
Topics: Animals; Cell Differentiation; Chromones; Deoxyglucose; DNA, Complementary; Glucose; Insulin; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Morpholines; Muscle, Skeletal; Myoblasts; Myristoylated Alanine-Rich C Kinase Substrate; Phosphoserine; Phosphothreonine; Protein Kinase C; Protein Kinase C beta; Rats; RNA, Small Interfering | 2009 |
Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK.
Topics: Animals; Carrier Proteins; Cell Line; Cell Survival; Cytoskeletal Proteins; Humans; Interleukin-3; Mice; Microfilament Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Substrate Specificity; Trans-Activators; Transcription, Genetic | 2009 |
Discovery and identification of serine and threonine phosphorylated proteins in activated mast cells: implications for regulation of protein synthesis in the rat basophilic leukemia mast cell line RBL-2H3.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromatography, Affinity; Immunoprecipitation; Leukemia, Basophilic, Acute; Mast Cells; Myosins; Peptide Elongation Factor 2; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Rats | 2009 |
Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein.
Topics: Amino Acids; Animals; Apoptosis Regulatory Proteins; Cardiovascular Abnormalities; Carrier Proteins; Cell Line; Exons; Frameshift Mutation; Gene Knockdown Techniques; Heart; Humans; Intracellular Signaling Peptides and Proteins; KRIT1 Protein; Membrane Proteins; Microtubule-Associated Proteins; Phenotype; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Sequence Deletion; Zebrafish; Zebrafish Proteins | 2009 |
Selective enrichment in phosphopeptides for the identification of phosphorylated mitochondrial proteins.
Topics: Animals; Humans; Mass Spectrometry; Mitochondrial Proteins; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 2009 |
Caenorhabditis elegans has a phosphoproteome atypical for metazoans that is enriched in developmental and sex determination proteins.
Topics: Adenosine Triphosphatases; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cluster Analysis; Conserved Sequence; Databases, Genetic; DNA-Binding Proteins; Multiprotein Complexes; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phylogeny; Proteome; Proteomics; Sex Determination Processes | 2009 |
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.
Topics: Blotting, Western; Cell Line; Chromatography, Liquid; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Mass Spectrometry; Mutant Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Structure-Activity Relationship; Time Factors | 2009 |
Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography-tandem mass s
Topics: Amino Acid Sequence; Animals; Chromatography, Liquid; Membrane Proteins; Molecular Sequence Data; Peptide Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Plasmodium falciparum; Protein Kinases; Protozoan Proteins; Substrate Specificity; Tandem Mass Spectrometry | 2009 |
Site-specifically phosphorylated forms of H1.5 and H1.2 localized at distinct regions of the nucleus are related to different processes during the cell cycle.
Topics: Antibodies; Antibody Specificity; Cell Cycle; Cell Nucleus; Chromatography; DNA Replication; Epitopes; Fluorescent Antibody Technique; HeLa Cells; Histones; Humans; Microscopy, Confocal; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Staurosporine; Transcription, Genetic | 2009 |
Protein phosphorylation by semisynthesis: from paper to practice.
Topics: Alanine; Animals; Humans; Inteins; Organophosphonates; Phenylalanine; Phosphoamino Acids; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Recombinant Fusion Proteins | 2009 |
Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages.
Topics: Cluster Analysis; Consensus Sequence; Culture Media; HeLa Cells; Humans; Mitosis; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Proteome; Reproducibility of Results; Spindle Apparatus; Time Factors | 2009 |
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Carrier Proteins; Chromatography, Liquid; Conserved Sequence; HeLa Cells; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Mass Spectrometry; Mice; Models, Biological; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Vertebrates | 2009 |
Analysis of phosphorylated peptides by double pseudoneutral loss extraction coupled with derivatization using N-(4-bromobenzoyl)aminoethanethiol.
Topics: Chemistry Techniques, Analytical; Phosphoproteins; Phosphoserine; Phosphothreonine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2009 |
Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Caspase 3; Cell Line; Enzyme Activation; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 3; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Membrane Proteins; Mice; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA-Binding Proteins; Transcription Factor AP-1; Transcription, Genetic | 2010 |
Conformational preferences and prolyl cis-trans isomerization of phosphorylated Ser/Thr-Pro motifs.
Topics: Amino Acid Motifs; Dipeptides; Hydrogen Bonding; Isomerism; Models, Molecular; Phosphoserine; Phosphothreonine; Proline; Protein Structure, Secondary; Thermodynamics | 2010 |
Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.
Topics: Amino Acid Sequence; Cell Line; Gene Expression Regulation, Viral; Gene Products, rex; Human T-lymphotropic virus 1; Humans; Molecular Sequence Data; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine | 2009 |
Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Cytoskeleton; Humans; Mice; Mice, Inbred mdx; Microfilament Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; Muscle Cells; Muscle, Skeletal; Muscular Dystrophy, Animal; Mutagenesis, Insertional; Oncogene Proteins; Organ Specificity; Phosphorylation; Phosphoserine; Phosphothreonine; Proline; Protein Binding; Protein Transport; Sequence Analysis, Protein; Substrate Specificity; Up-Regulation | 2010 |
Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.
Topics: Amino Acid Sequence; Animals; Antibodies, Phospho-Specific; Calcium; Calcium Signaling; Cyclic GMP; Dictyostelium; Intracellular Space; Models, Biological; Molecular Sequence Data; Osmotic Pressure; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protozoan Proteins; STAT Transcription Factors; Stress, Physiological | 2010 |
h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
Topics: Actins; Animals; Calcium-Binding Proteins; Calponins; Down-Regulation; Fibroblasts; Gene Knockdown Techniques; Intracellular Space; Mice; Microfilament Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscles; NIH 3T3 Cells; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Transport; Rats; Wound Healing | 2010 |
The masticatory contractile load induced expression and activation of Akt1/PKBalpha in muscle fibers at the myotendinous junction within muscle-tendon-bone unit.
Topics: Animals; Bone and Bones; Immunoblotting; Immunohistochemistry; Male; Masticatory Muscles; Muscle Contraction; Muscle Fibers, Skeletal; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Tendons; Weight-Bearing | 2010 |
Phosphorylated and nonphosphorylated serine and threonine residues evolve at different rates in mammals.
Topics: Animals; Conserved Sequence; Evolution, Molecular; Humans; Mammals; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Phylogeny | 2010 |
Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Death; Cell Survival; Dual-Specificity Phosphatases; Embryonic Development; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Mammals; Mass Spectrometry; Mitogen-Activated Protein Kinase Phosphatases; Morphogenesis; Myristic Acid; Phosphoprotein Phosphatases; Phosphoserine; Phosphothreonine; Phosphotyrosine; Signal Transduction; Substrate Specificity; Transfection | 2010 |
Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bloom Syndrome; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; Humans; Molecular Sequence Data; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Serine-Threonine Kinases; Protein Transport; RecQ Helicases | 2010 |
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p27; Mice; Molecular Sequence Data; Mutation; Neural Stem Cells; Neurites; Neurogenesis; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Transport; RNA, Small Interfering; Substrate Specificity; Transfection | 2010 |
Activation of Atg1 kinase in autophagy by regulated phosphorylation.
Topics: Amino Acid Sequence; Autophagy; Autophagy-Related Proteins; Conserved Sequence; Enzyme Activation; Molecular Sequence Data; Mutation; Phagosomes; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus | 2010 |
DDK phosphorylates checkpoint clamp component Rad9 and promotes its release from damaged chromatin.
Topics: Amino Acid Sequence; Camptothecin; Cell Cycle; Cell Cycle Proteins; Chromatin; DNA Damage; DNA Repair; DNA Replication; Enzyme Activation; Kinetics; Models, Biological; Molecular Sequence Data; Mutant Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Replication Protein A; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Solubility; Subcellular Fractions; Time Factors | 2010 |
p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.
Topics: Antigens, CD; Cadherins; Cell Nucleus; Cells, Cultured; Cytokines; DNA; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Humans; Keratins; MAP Kinase Kinase Kinases; Models, Biological; NF-kappa B; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Phosphatase 2; Protein Transport; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Twist-Related Protein 1 | 2010 |
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Enzyme Activation; Female; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Phosphoserine; Phosphothreonine; Phosphotyrosine; Up-Regulation | 2011 |
Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding.
Topics: 14-3-3 Proteins; Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; Intracellular Signaling Peptides and Proteins; Models, Biological; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2011 |
Tandem mass spectrometric method for definitive localization of phosphorylation sites using bromine signature.
Topics: Bromine; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Tandem Mass Spectrometry | 2011 |
Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Female; Macrophages; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Operon; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Signal Transduction; Threonine | 2011 |
Tomato SlSnRK1 protein interacts with and phosphorylates βC1, a pathogenesis protein encoded by a geminivirus β-satellite.
Topics: DNA, Viral; Geminiviridae; Gene Expression Regulation, Plant; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Plant Diseases; Plant Proteins; Protein Binding; Protein Interaction Domains and Motifs; Satellite Viruses; Solanum lycopersicum; Subcellular Fractions; Viral Proteins | 2011 |
Modelling of the gas-phase phosphate group loss and rearrangement in phosphorylated peptides.
Topics: Ions; Mass Spectrometry; Molecular Dynamics Simulation; Phosphopeptides; Phosphoric Acids; Phosphorylation; Phosphoserine; Phosphothreonine; Thermodynamics | 2011 |
Unusual fragmentation of Pro-Ser/Thr-containing peptides detected in collision-induced dissociation spectra.
Topics: Amino Acid Sequence; Databases, Protein; Molecular Sequence Data; Oligopeptides; Oxazoles; Phosphoric Acids; Phosphoserine; Phosphothreonine; Proline; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Comparison of three quantitative phosphoproteomic strategies to study receptor tyrosine kinase signaling.
Topics: Animals; Cell Line, Tumor; Chromatography, Affinity; Computational Biology; Ephrin-B1; Immunoprecipitation; Isotope Labeling; Mice; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Interaction Mapping; Protein Interaction Maps; Proteomics; Rats; Receptors, Eph Family; Signal Transduction; Titanium | 2011 |
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infarction, Middle Cerebral Artery; Mice; Neurons; Neuroprotective Agents; Nicotinamide Phosphoribosyltransferase; Oxygen; Phagosomes; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirtuin 1; Stress, Physiological; Stroke; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2012 |
Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction.
Topics: Binding Sites; Cell Cycle Proteins; Checkpoint Kinase 2; Crystallography, X-Ray; DNA Damage; Histone Chaperones; Histones; Hydroxyurea; Models, Molecular; Molecular Chaperones; Mutant Proteins; Mutation; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Stability; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2012 |
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; HEK293 Cells; Humans; Insect Proteins; Membrane Potential, Mitochondrial; Parkinson Disease; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Tertiary; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Tribolium; Ubiquitin-Protein Ligases | 2012 |
Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyclin-Dependent Kinases; Endosomal Sorting Complexes Required for Transport; Humans; Kidney; Kinesins; Mice; Microtubules; Molecular Sequence Data; Nedd4 Ubiquitin Protein Ligases; Phosphorylation; Phosphoserine; Phosphothreonine; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Binding; Proteolysis; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; DNA-Activated Protein Kinase; DNA-Binding Proteins; Epithelial Cells; ErbB Receptors; Humans; Mutant Proteins; Mutation; Nuclear Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Radiation Tolerance; Radiation, Ionizing; Structure-Activity Relationship; Tumor Suppressor Proteins | 2012 |
AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.
Topics: 14-3-3 Proteins; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Autophagy-Related Protein-1 Homolog; Autophagy-Related Proteins; Catalytic Domain; Embryo, Mammalian; Enzyme Activation; Fibroblasts; HEK293 Cells; Humans; Membrane Proteins; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Stability; Protein Subunits; Protein Transport; Signal Transduction; Stress, Physiological; Transcription Factor TFIIH; Transcription Factors; Vesicular Transport Proteins | 2012 |
Formation and dissociation of phosphorylated peptide radical cations.
Topics: Cations; Free Radicals; Mass Spectrometry; Models, Molecular; Phosphopeptides; Phosphoric Acids; Phosphoserine; Phosphothreonine | 2012 |
An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase.
Topics: Amino Acid Substitution; Peptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Sorting Signals; Substrate Specificity | 2012 |
Antibody-free detection of phosphoserine/threonine containing peptides by homogeneous time-resolved fluorescence.
Topics: Amino Acid Sequence; Checkpoint Kinase 2; Molecular Sequence Data; Peptides; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Spectrometry, Fluorescence | 2012 |
p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2).
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; HEK293 Cells; Humans; Male; Mice; Models, Biological; p21-Activated Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Prostatic Neoplasms; Protein Transport; Proteolysis; Proto-Oncogene Proteins c-mdm2; Receptors, Androgen; Ubiquitin; Ubiquitin-Protein Ligases | 2013 |
Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.
Topics: Amino Acid Sequence; Animals; Biomechanical Phenomena; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Compliance; Connectin; Diastole; Heart Failure; Humans; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; Muscle Proteins; Myocytes, Cardiac; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins | 2013 |
Specificity profiling of protein phosphatases toward phosphoseryl and phosphothreonyl peptides.
Topics: Combinatorial Chemistry Techniques; Molecular Structure; Peptide Library; Peptides; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphothreonine; Substrate Specificity | 2013 |
Transfer of Ser7 phosphorylated CENP-A from centromere to midbody during mitosis in MCF-7 cells.
Topics: Adenocarcinoma; Autoantigens; Biological Transport; Breast Neoplasms; Centromere; Centromere Protein A; Chromosomal Proteins, Non-Histone; Cytokinesis; Female; Histones; Humans; MCF-7 Cells; Microscopy, Confocal; Microscopy, Fluorescence; Mitosis; Neoplasm Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Pregnancy; Protein Processing, Post-Translational; Spindle Apparatus | 2013 |
Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association.
Topics: Amino Acid Motifs; Animals; Cell Line, Tumor; Early Growth Response Transcription Factors; Humans; Kruppel-Like Transcription Factors; Mice; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Protein Interaction Mapping; Protein Stability; Proteolysis; Proto-Oncogene Proteins c-raf; Tumor Suppressor Proteins | 2013 |
Structure-function study of deinococcal serine/threonine protein kinase implicates its kinase activity and DNA repair protein phosphorylation roles in radioresistance of Deinococcus radiodurans.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Deinococcus; DNA Ligases; DNA Repair; DNA, Bacterial; Genetic Complementation Test; Lysine; Molecular Sequence Data; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Radiation Tolerance; Structure-Activity Relationship; Substrate Specificity | 2013 |
cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway.
Topics: Alprostadil; Blood Platelets; Cell Shape; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Multiprotein Complexes; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Subunits; rho-Associated Kinases; rhoA GTP-Binding Protein; Second Messenger Systems; Signal Transduction; Thrombin | 2013 |
Phosphorylation pattern of Rubisco activase in Arabidopsis leaves.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Biocatalysis; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Photosynthesis; Plant Leaves; Sequence Analysis, Protein | 2014 |
Multisite phosphorylation networks as signal processors for Cdk1.
Topics: Adaptor Proteins, Signal Transducing; CDC2 Protein Kinase; Cell Cycle Proteins; Cyclin B; Cyclins; Phosphorylation; Phosphoserine; Phosphothreonine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2013 |
The family-wide structure and function of human dual-specificity protein phosphatases.
Topics: Catalytic Domain; Crystallography, X-Ray; Cysteine; Dual-Specificity Phosphatases; Enzyme Inhibitors; Escherichia coli; Humans; Hydrolysis; Models, Molecular; Oxidation-Reduction; Phosphoserine; Phosphothreonine; Phosphotyrosine; Phylogeny; Protein Structure, Secondary; Recombinant Proteins; Signal Transduction; Structural Homology, Protein; Substrate Specificity | 2014 |
Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.
Topics: Calcium; Cyclic AMP-Dependent Protein Kinases; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myocytes, Cardiac; Myofibrils; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Sarcomeres; Troponin I | 2014 |
Expanded cellular amino acid pools containing phosphoserine, phosphothreonine, and phosphotyrosine.
Topics: Amino Acyl-tRNA Synthetases; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Genetic Engineering; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins | 2014 |
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin A2; Cyclin-Dependent Kinase 2; Embryonic Stem Cells; Enzyme Activation; Male; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Neoplasms; Olfactory Bulb; Oncogene Protein v-akt; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2014 |
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells.
Topics: Cell Line, Tumor; Cyclic GMP-Dependent Protein Kinase Type II; Epidermal Growth Factor; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Receptor, ErbB-2; Stomach Neoplasms | 2016 |
Doubling down on phosphorylation as a variable peptide modification.
Topics: Algorithms; Databases, Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Proteins; Proteomics; Signal Processing, Computer-Assisted; Soybean Proteins; Tandem Mass Spectrometry | 2016 |
Redox regulation of a guard cell SNF1-related protein kinase in
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Brassica napus; Crops, Agricultural; Cysteine; Hydrogen Peroxide; Manganese; Oxidation-Reduction; Phosphorylation; Phosphoserine; Phosphothreonine; Phylogeny; Plant Stomata; Protein Serine-Threonine Kinases; Sequence Alignment; Thioredoxins | 2017 |
Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Disks Large Homolog 4 Protein; Escherichia coli; Gene Expression; Glutathione Transferase; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Microtubule-Associated Proteins; Models, Molecular; Molecular Mimicry; Phosphoserine; Phosphothreonine; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2017 |
Neutralizing the Detrimental Effect of an N-Hydroxysuccinimide Quenching Reagent on Phosphopeptide in Quantitative Proteomics.
Topics: Humans; Hydroxylamine; Indicators and Reagents; Phosphopeptides; Phosphoserine; Phosphothreonine; Proteomics; Succinimides | 2018 |
Selectivity within a Family of Bacterial Phosphothreonine Lyases.
Topics: Amino Acid Sequence; Bacteria; Kinetics; Lyases; Mitogen-Activated Protein Kinases; Models, Molecular; Peptides; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Substrate Specificity | 2018 |
Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Genes, Reporter; HEK293 Cells; Humans; Ligands; Mice; Models, Molecular; Nociceptin Receptor; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Receptors, Opioid; Recombinant Proteins; Structure-Activity Relationship | 2019 |
Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.
Topics: Animals; Cell Line, Tumor; Mice; Mutation; Phosphoserine; Phosphothreonine; Receptors, Granulocyte Colony-Stimulating Factor; Serine; Signal Transduction; Threonine | 2019 |
Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors.
Topics: Cell Cycle Proteins; Peptides; Phosphoserine; Phosphothreonine; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Triazoles | 2019 |
Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation.
Topics: Amino Acid Sequence; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; HEK293 Cells; Humans; Isoenzymes; Melanoma; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Receptor, ErbB-4 | 2019 |
Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling.
Topics: Abscisic Acid; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; MAP Kinase Kinase Kinases; Phenotype; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Multimerization; Signal Transduction | 2019 |
Dynamics and Regulations of BimEL Ser65 and Thr112 Phosphorylation in Porcine Granulosa Cells during Follicular Atresia.
Topics: Animals; Apoptosis; Bcl-2-Like Protein 11; Cell Survival; Cells, Cultured; Female; Follicular Atresia; Granulosa Cells; Models, Biological; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Swine | 2020 |
Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2.
Topics: Amino Acid Motifs; Casein Kinase I; Cilia; HEK293 Cells; Humans; Multiprotein Complexes; Organogenesis; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Substrate Specificity | 2020 |
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Topics: Aneuploidy; BRCA2 Protein; Breast Neoplasms; Cell Cycle Proteins; Chromosome Segregation; Chromosomes, Human; Female; Genetic Variation; HeLa Cells; Homologous Recombination; Humans; Kinetics; Kinetochores; Mitosis; Molecular Docking Simulation; Phosphorylation; Phosphoserine; Phosphothreonine; Polo-Like Kinase 1; Protein Binding; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins | 2020 |
Multiple Site-Specific Phosphorylation of IDPs Monitored by NMR.
Topics: BRCA2 Protein; Cell Cycle Proteins; Humans; Intrinsically Disordered Proteins; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphothreonine; Polo-Like Kinase 1; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Recombinant Proteins | 2020 |
The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; HEK293 Cells; Humans; I-kappa B Kinase; Inflammation; Male; Mice; Models, Biological; Mutation; Phosphorylation; Phosphoserine; Phosphothreonine; Prostate; Protein Binding; Protein Stability; Proto-Oncogene Proteins c-myc; Transcription, Genetic | 2021 |
Quantitation of phosphohistidine in proteins in a mammalian cell line by 31P NMR.
Topics: Animals; Cell Line; Histidine; Humans; Mammals; Phosphorylation; Phosphoserine; Phosphothreonine; Proteins | 2022 |
Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells.
Topics: Animals; Dual Specificity Phosphatase 1; Dual-Specificity Phosphatases; Mesoderm; Mice; Mitogen-Activated Protein Kinases; Mouse Embryonic Stem Cells; Phosphoserine; Phosphothreonine; Phosphotyrosine | 2022 |
Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1.
Topics: Enzyme Inhibitors; Myosin-Light-Chain Phosphatase; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Phosphatase 1 | 2023 |