phosphoserine has been researched along with epidermal growth factor in 67 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (8.96) | 18.7374 |
1990's | 22 (32.84) | 18.2507 |
2000's | 25 (37.31) | 29.6817 |
2010's | 14 (20.90) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Bird, TA; Saklatvala, J | 1 |
Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
Clinton, GM; Li, SW; Lin, YZ | 1 |
Iwashita, S; Mitsui, K | 1 |
Ballou, LM; Luther, H; Thomas, G | 1 |
Contreras, ML; Fink, D; Guroff, G; Kim, HS; Kim, UH; Park, DJ; Rhee, SG | 1 |
Abdel-Ghany, M; Koland, J; Racker, E; Revis-Gupta, S | 1 |
Anderson, NG; Erickson, AK; Ray, LB; Sturgill, TW | 1 |
Erickson, AK; Ray, LB; Sturgill, TW | 1 |
Cohen, S; Sawyer, ST | 1 |
Hollenberg, MD; Pallen, CJ; Valentine, KA; Wang, JH | 1 |
David-Pfeuty, T; Guesdon, F | 1 |
Chong, SM; Khanna, NC; Tokuda, M; Waisman, DM | 1 |
Blackshear, PJ; Girard, PR; Kuo, JF; Quamo, SN; Witters, LA | 1 |
Alitalo, K; Bornstein, P; Keski-Oja, J | 1 |
Cuveele, JF; de Witte, PA; Merlevede, WJ; Vandenheede, JR | 1 |
Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
Cohen, P; Saito, Y; Vandenheede, JR | 1 |
Hayashi, T; Imura, H; Inoue, G; Kono, S; Kosaki, A; Kuzuya, H; Nishimura, H; Okamoto, M; Yamada, K; Yoshimasa, Y | 1 |
Ascoli, M; Hoelscher, SR | 1 |
McCormick, F; Porfiri, E | 1 |
Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A | 1 |
Balaban, N; Goldkorn, T; Matsukuma, K; Shannon, M | 1 |
Mollerup, S; Rivedal, E; Sanner, T; Vikhamar, G | 1 |
Allis, CD; Bazett-Jones, DP; Chadee, DN; Davie, JR; Hendzel, MJ; Tylipski, CP; Wright, JA | 1 |
Mercurio, AM; Rabinovitz, I; Toker, A | 1 |
Cao, X; Lim, CP | 1 |
Moelling, K; Zimmermann, S | 1 |
Dalakas, MC; Li, M | 1 |
Cochran, BH; Fanburg, BL; Guan, KL; Simon, AR; Stewart, S; Vikis, HG | 1 |
Berg, AH; Engelman, JA; Lewis, RY; Lisanti, MP; Scherer, PE | 1 |
Chung, J; Jee, K; Kim, D; Kim, S; Koh, H | 1 |
Epstein, RJ; Gulliford, T; Huang, G; Ouyang, X; Smith, G; Zhang, H | 1 |
Felts, N; Floyd, RA; Hensley, K; Pye, QN; Salsman, S | 1 |
Luo, Z; Ruderman, N; Song, Y; Wen, R; Xiang, X; Yuan, M | 1 |
Kim, YH; Kim, YS; Lee, YH; Shin, SY; Yoon, SC | 1 |
Frank, SJ; Huang, Y; Jiang, J; Kim, SO | 1 |
Hunger-Glaser, I; Rozengurt, E; Salazar, EP; Sinnett-Smith, J | 1 |
Abrahamsen, H; Andersson, Y; Christoffersen, T; Guren, TK; Susa, M; Thoresen, GH; Ødegård, J; Østby, E | 1 |
Halldórsson, H; Thorgeirsson, G; Thors, B | 1 |
Alfonso, M; Campbell, DG; Cohen, P; Mora, A; Murray, JT; Peggie, M | 1 |
Ando, Y; Fujii, Y; Hamaguchi, M; Iwase, H; Kobayashi, S; Mita, K; Nishio, M; Sugiura, H; Yamashita, H; Zhang, Z | 1 |
Argetsinger, LS; Carter-Su, C; Cline, JM; Jensen, ON; Kouadio, JL; Mazurkiewicz-Munoz, AM; Stensballe, A | 1 |
Betapudi, V; Bresnick, AR; Dulyaninova, NG; House, RP | 1 |
Kuikman, I; Litjens, SH; Margadant, C; Sonnenberg, A; van Rheenen, J; Wilhelmsen, K | 1 |
Kitamura, N; Komada, M; Mizuno, E | 1 |
Carr, HS; Dan, I; Frost, JA; Ruvolo, PP; Wu, X | 1 |
Jang, IH; Jung, H; Lee, HY; Ryu, SH; Suh, PG | 1 |
Ge, BX; Huang, Z; Yan, DP | 1 |
Chen, C; Gong, J; Huang, Q; Huang, W; Luo, L; Luo, X; Luo, Z; Olbrot, M; Peng, Y; Xiang, X; Zang, M; Zhou, J | 1 |
Bai, X; Beryt, M; Brdlik, C; Higaki, JN; Jin, P; Jorgensen, B; Kumari, R; Lau, FW; Lindley, P; Liu, J; Ni, I; Rozzelle, J; Sarup, J; Shepard, HM; Turin, L; Watson, SA; Zhang, J | 1 |
Moran, MF; Peterman, SM; Prakash, A; Taylor, P; Tong, J | 1 |
Abdel Fattah, E; Eissa, NT; Gorgun, FM; Mazumdar, T; Pandit, L; Tyryshkin, A; Zeng, S | 1 |
Aldape, K; Fang, B; Fang, D; Fang, X; Ge, Q; Hawke, D; Ji, H; Keezer, S; Litchfield, DW; Lu, Z; Nika, H; Wang, J | 1 |
Flinder, LI; Huitfeldt, HS; Rosseland, CM; Skarpen, E; Timofeeva, OA; Wierød, L | 1 |
Dunn, TJ; Gao, J; Gao, T; Hooten, KG; Ojeda, L; Thonhoff, JR; Wang, E; Wu, P | 1 |
Ishigaki, Y; Kajinami, K; Kawai, Y; Takata, T; Takeda, K | 1 |
Kim, JH; Kim, YB; Shin, YJ | 1 |
Anichini, A; Canevari, S; Rea, K; Sensi, M; Tomassetti, A | 1 |
Corson, GM; Mandel, G; McCleskey, M; Nesti, E; Oyer, JA | 1 |
Besik, V; Breit, A; Glas, E; Gudermann, T; Muehlich, S; Solinski, HJ; Yarwood, SJ | 1 |
Chen, Y; Qian, H; Wu, M; Wu, Y; Yao, X; Zhu, M | 1 |
Ji, H; Lee, JH; Lu, Z; Lyu, J; Pang, Y; Wang, Y; Xia, Y; Zhang, T; Zhong, L | 1 |
Hamaoka, Y; Katoh, H; Negishi, M | 1 |
Cao, R; Li, X; Liang, J; Lu, Z; Wang, L; Xia, Y; Yang, W; Zhang, Y; Zheng, Y | 1 |
Frost, JA; Oh, W; Ulu, A; Zuo, Y | 1 |
Cai, Z; Han, F; Jin, G; Li, CF; Lin, HK; Morrow, J; Wang, CY; Wang, G; Xu, C; Xu, D; Zhang, S; Zhang, WN; Zhang, X | 1 |
1 trial(s) available for phosphoserine and epidermal growth factor
Article | Year |
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The muscle mitogen-activated protein kinase is altered in sporadic inclusion body myositis.
Topics: Aged; Animals; Biopsy; Blotting, Western; Cytoskeletal Proteins; Epidermal Growth Factor; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Middle Aged; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; Myositis, Inclusion Body; PC12 Cells; Phosphorylation; Phosphoserine; Rats; Vacuoles | 2000 |
66 other study(ies) available for phosphoserine and epidermal growth factor
Article | Year |
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Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Examination of the role of serine phosphorylation in phospholipase C-gamma and its related P47 in cAMP-mediated depression of epidermal growth factor signal transduction.
Topics: Colforsin; Cross Reactions; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1990 |
MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways.
Topics: Adipose Tissue; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Reactivators; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Xenopus | 1991 |
Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; In Vitro Techniques; Isoenzymes; Nerve Growth Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Type C Phospholipases; Tyrosine | 1991 |
Heparin stimulates epidermal growth factor receptor-mediated phosphorylation of tyrosine and threonine residues.
Topics: Amino Acids; Animals; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Glutathione Transferase; Heparin; Humans; Insecta; Manganese; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Threonine; Tyrosine | 1991 |
Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Autoradiography; Buffers; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Indicators and Reagents; Kinetics; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation.
Topics: Animals; Epidermal Growth Factor; Fibroblasts; In Vitro Techniques; Insulin; Mice; Microtubule-Associated Proteins; Molecular Weight; Phosphoproteins; Phosphoserine; Precipitin Tests; Protein Kinases | 1990 |
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.
Topics: Animals; Autoradiography; Calcium; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Time Factors; Tyrosine | 1985 |
Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone.
Topics: Brain; Calmodulin-Binding Proteins; Cations, Monovalent; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptors, Cell Surface; Tyrosine | 1985 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
Phosphorylation of p36 in vitro by protein kinase C.
Topics: Animals; Cattle; Enzyme Activation; Epidermal Growth Factor; Lung; Nerve Tissue Proteins; Phosphoserine; Protein Kinase C; Protein-Tyrosine Kinases; Synapsins | 1986 |
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.
Topics: Animals; Brain; Cell Line; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Humans; Immunologic Techniques; Insulin; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1985 |
Effects of Zn2+ ions on protein phosphorylation in epithelial cell membranes.
Topics: Animals; Cations, Divalent; Cell Division; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelium; ErbB Receptors; Membrane Proteins; Mice; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Receptors, Cell Surface; Zinc | 1983 |
Analysis of phosphorylhydroxyamino acids present in hydrolyzed cell extracts using dabsyl derivatization.
Topics: Cell Extracts; Chromatography, Thin Layer; Electrophoresis; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; p-Dimethylaminoazobenzene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Protein-Tyrosine Kinases; Quercetin; Tumor Cells, Cultured; Tyrosine | 1995 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Ethers, Cyclic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Immunosuppressive Agents; Kinetics; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Polyenes; Protein Phosphatase 1; Radioisotope Dilution Technique; Sirolimus; Tumor Cells, Cultured | 1994 |
Preparation of anti-phosphoserine and anti-phosphothreonine antibodies and their application in the study of insulin- and EGF-induced phosphorylation.
Topics: Animals; Antibodies; CHO Cells; Chromatography, Affinity; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Kinetics; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Receptor, Insulin; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arginine Vasopressin; Chorionic Gonadotropin; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Insulin; Kinetics; Leydig Cell Tumor; Mice; Peptide Mapping; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Tumor Cells, Cultured | 1993 |
Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Kinetics; Mice; Mutagenesis; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis; Proteins; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Deletion; Sequence Tagged Sites; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aurintricarboxylic Acid; Breast Neoplasms; Carcinoma; Cell Survival; Cycloheximide; Cytosol; Epidermal Growth Factor; Heat-Shock Proteins; Humans; Insulin-Like Growth Factor I; Isoelectric Point; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1997 |
EGF receptor phosphorylation is affected by ionizing radiation.
Topics: Adenosine Triphosphate; Cell Division; Cell Line; Cell Membrane; Cesium Radioisotopes; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Gamma Rays; Humans; Kinetics; Methionine; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine | 1997 |
Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells.
Topics: Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Humans; Kidney; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromatin; Epidermal Growth Factor; Fluorescent Antibody Technique; Gene Expression Regulation; Genes, fos; Genes, myc; Genes, ras; Histones; Mice; Mitogens; Okadaic Acid; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1999 |
Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.
Topics: Actins; Antigens, Surface; Carbazoles; Carcinoma, Squamous Cell; Cell Membrane; Cell Size; Chemotaxis; Desmosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Integrin alpha6beta4; Integrins; Keratins; Laminin; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Pseudopodia; Signal Transduction; Tumor Cells, Cultured | 1999 |
Serine phosphorylation and negative regulation of Stat3 by JNK.
Topics: Amino Acid Substitution; Animals; COS Cells; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Point Mutation; Pyridines; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection; Ultraviolet Rays | 1999 |
Phosphorylation and regulation of Raf by Akt (protein kinase B).
Topics: Cell Division; Cell Line; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Fusion Proteins; Signal Transduction; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Regulation of STAT3 by direct binding to the Rac1 GTPase.
Topics: Amino Acid Substitution; Animals; Cell Line; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Guanine Nucleotide Exchange Factors; Humans; Janus Kinase 2; Mutation; Neoplasm Proteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; rac1 GTP-Binding Protein; Rats; Signal Transduction; STAT3 Transcription Factor; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Trans-Activators; Transfection; Two-Hybrid System Techniques | 2000 |
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anisomycin; Cell Differentiation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2000 |
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Kinetics; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer.
Topics: Animals; Antibodies, Monoclonal; Becaplermin; Breast Neoplasms; Cells, Cultured; Colforsin; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Immunoblotting; Mice; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Platelet-Derived Growth Factor; Prognosis; Proto-Oncogene Proteins c-sis; Receptor, ErbB-2; Transfection; Vanadates | 2001 |
Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN.
Topics: Acetylcysteine; Androstadienes; Animals; Antimycin A; Astrocytes; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rotenone; Signal Transduction; Tumor Suppressor Proteins; Uncoupling Agents; Wortmannin | 2001 |
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Biological Transport; Cell Nucleus; COS Cells; Cytoplasm; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescent Antibody Technique; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Microscopy, Confocal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2002 |
Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts.
Topics: Animals; Cyclin D1; Epidermal Growth Factor; Fibroblasts; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mitogens; Phospholipase C gamma; Phosphorylation; Phosphoserine; Protein Kinase C; Rats; Signal Transduction; Type C Phospholipases | 2002 |
Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Antigens, CD; Carrier Proteins; Cytokine Receptor gp130; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Immunoblotting; Indoles; Janus Kinase 2; Maleimides; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, ErbB-2; Recombinant Fusion Proteins; Signal Transduction; Transfection; Ubiquitin-Protein Ligases | 2003 |
Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation.
Topics: 3T3 Cells; Animals; Base Sequence; Bombesin; DNA Primers; Enzyme Activation; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Lysophospholipids; MAP Kinase Signaling System; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Recombinant Fusion Proteins | 2003 |
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes.
Topics: Animals; Cell Division; Cells, Cultured; DNA; DNA-Binding Proteins; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Growth Hormone; Hepatocytes; Male; Milk Proteins; Mitogens; Phosphorylation; Phosphoserine; Phosphotyrosine; Prolactin; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Pyrroles; Rats; Rats, Wistar; STAT5 Transcription Factor; Trans-Activators; Transforming Growth Factor alpha | 2003 |
Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt.
Topics: AMP-Activated Protein Kinases; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; Histamine; Humans; Multienzyme Complexes; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Thrombin | 2004 |
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Animals; Antibody Specificity; Benzamides; Cell Extracts; Cell Line; Contractile Proteins; Epidermal Growth Factor; Filamins; Humans; Immediate-Early Proteins; Insulin; Isoenzymes; Mice; Microfilament Proteins; Molecular Sequence Data; Molecular Weight; Muscle, Skeletal; Myoblasts; Myocardium; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Signal Transduction; Sirolimus; Substrate Specificity; Wortmannin | 2004 |
Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Phosphorylation; Phosphoserine; Prognosis; Receptor, ErbB-2; Receptors, Progesterone; Recombinant Proteins; Recurrence; Survival Analysis; Transfection | 2005 |
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
Topics: 3T3 Cells; Alanine; Animals; Butadienes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Janus Kinase 2; MAP Kinase Kinase 1; Mass Spectrometry; Mice; Mutation; Nitriles; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Repressor Proteins; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells.
Topics: Amino Acid Substitution; Casein Kinase II; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Focal Adhesions; Humans; Mutant Proteins; Myosin Heavy Chains; Nonmuscle Myosin Type IIA; Phosphorylation; Phosphoserine; Protein Binding; Protein Isoforms; Protein Transport; Pseudopodia; Solubility | 2007 |
Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Hemidesmosomes; Humans; Integrin beta4; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Plectin; Protein Kinase C; Protein Structure, Tertiary; Protein Subunits | 2007 |
14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Amino Acid Sequence; Animals; Catalysis; Cell Division; Chlorocebus aethiops; COS Cells; Endopeptidases; Endosomal Sorting Complexes Required for Transport; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; Mice; Molecular Sequence Data; Mutant Proteins; Phosphorylation; Phosphoserine; Protein Binding; Protein Transport; Subcellular Fractions; Substrate Specificity; Ubiquitin; Ubiquitin Thiolesterase | 2007 |
p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Mitochondria; Mitogen-Activated Protein Kinases; p21-Activated Kinases; Phosphoserine; Protein Binding; Proto-Oncogene Proteins c-raf | 2008 |
Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyclin-Dependent Kinase 5; Enzyme Activation; Epidermal Growth Factor; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Molecular Sequence Data; Phospholipase D; Phosphorylation; Phosphoserine; Protein Binding; Rats; Substrate Specificity | 2008 |
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.
Topics: Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Epithelium, Corneal; Focal Adhesion Protein-Tyrosine Kinases; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Models, Biological; Mutant Proteins; Paxillin; Phosphorylation; Phosphoserine; Phosphotyrosine | 2008 |
Characterization of Ser338 phosphorylation for Raf-1 activation.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; Humans; Mutation; p21-Activated Kinases; Phosphoserine; Protein Multimerization; Proto-Oncogene Proteins c-raf | 2008 |
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Proliferation; Cloning, Molecular; Dimerization; Drug Synergism; Epidermal Growth Factor; Humans; Immunoglobulin Fc Fragments; Ligands; Mice; Neuregulin-1; Phosphoserine; Protein Kinase Inhibitors; Protein Structure, Tertiary; Receptor, ErbB-2; Receptor, ErbB-3; Trastuzumab; Xenograft Model Antitumor Assays | 2008 |
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.
Topics: Blotting, Western; Cell Line; Chromatography, Liquid; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Mass Spectrometry; Mutant Proteins; Phosphorylation; Phosphoserine; Phosphothreonine; Structure-Activity Relationship; Time Factors | 2009 |
Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme Activation; Enzyme Stability; Epidermal Growth Factor; Epithelium; Half-Life; Humans; Lung; Mice; Mice, Inbred C57BL; Models, Biological; Neoplasms; Nitric Oxide Synthase Type II; Phosphorylation; Phosphoserine; Pneumonia; Protein Transport; src-Family Kinases | 2010 |
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.
Topics: alpha Catenin; Amino Acid Sequence; beta Catenin; Binding Sites; Casein Kinase II; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Molecular Sequence Data; Neoplasm Invasiveness; Phosphorylation; Phosphoserine; Protein Binding; Transcriptional Activation | 2009 |
EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase.
Topics: Animals; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Hepatocytes; Male; Mice; Models, Biological; NADPH Oxidases; Phosphorylation; Phosphoserine; rac1 GTP-Binding Protein; Rats; Rats, Wistar | 2011 |
Critical role of PI3K/Akt/GSK3β in motoneuron specification from human neural stem cells in response to FGF2 and EGF.
Topics: Animals; Cell Differentiation; Cell Lineage; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homeodomain Proteins; Humans; Male; Motor Neurons; Neural Stem Cells; Phosphatidylinositol 3-Kinase; Phosphorylation; Phosphoserine; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors | 2011 |
Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Animals; Checkpoint Kinase 1; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mutant Proteins; Mutation; Phosphorylation; Phosphoserine; Protein Binding; Protein Isoforms; Protein Kinases; Protein Stability; Protein Transport; Rats; Substrate Specificity | 2013 |
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1.
Topics: Animals; Biocatalysis; Blotting, Western; Casein Kinase II; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; Humans; Male; Mass Spectrometry; Mice; Models, Biological; Mutation; p21-Activated Kinases; Phosphorylation; Phosphoserine; Prostate; Reproducibility of Results | 2013 |
EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 5; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Integrins; MAP Kinase Signaling System; Microtubules; Mitosis; Neoplasms; Phosphorylation; Phosphoserine; Polymerization; Spindle Apparatus | 2013 |
C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
Topics: Animals; beta-Transducin Repeat-Containing Proteins; Cell Differentiation; Chickens; Chromatin; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Green Fluorescent Proteins; HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Mutation; Neurons; NIMA-Interacting Peptidylprolyl Isomerase; Nuclear Proteins; PC12 Cells; Peptides; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Binding; Protein Stability; Proteolysis; ras Proteins; Rats; Repressor Proteins | 2014 |
Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.
Topics: Animals; Bradykinin; Cell Line; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Humans; Hypothalamus; Interferon-gamma; Ligands; Melanocyte-Stimulating Hormones; Mice; Neurons; Neuropeptide Y; Phosphorylation; Phosphoserine; Phosphotyrosine; Promoter Regions, Genetic; Receptors, Cytokine; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thyrotropin-Releasing Hormone; Transcriptional Activation | 2015 |
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells.
Topics: Cell Line, Tumor; Cyclic GMP-Dependent Protein Kinase Type II; Epidermal Growth Factor; Humans; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Binding; Receptor, ErbB-2; Stomach Neoplasms | 2016 |
EGFR phosphorylates FAM129B to promote Ras activation.
Topics: Amino Acid Sequence; Antibody Specificity; beta Catenin; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Models, Biological; Molecular Sequence Data; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Binding; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Transcriptional Activation | 2016 |
EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation.
Topics: Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Glioblastoma; Humans; MAP Kinase Signaling System; Phosphorylation; Phosphoserine; Receptor, EphA2; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction | 2016 |
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.
Topics: Animals; beta Catenin; Brain Neoplasms; Carcinogenesis; cdc25 Phosphatases; Cell Line, Tumor; Cell Nucleus; Epidermal Growth Factor; Glioblastoma; Glycolysis; Humans; Mice; Phosphorylation; Phosphoserine; Phosphotyrosine; Prognosis; Protein Binding; Proto-Oncogene Proteins c-myc; Pyruvate Kinase; src-Family Kinases; Transcriptional Activation | 2016 |
Stress-activated MAPKs and CRM1 regulate the subcellular localization of Net1A to control cell motility and invasion.
Topics: Cell Movement; Cytosol; Epidermal Growth Factor; Exportin 1 Protein; Extracellular Matrix; Glutamic Acid; Humans; Karyopherins; MCF-7 Cells; Mitogen-Activated Protein Kinases; Mutation; Oncogene Proteins; Phosphorylation; Phosphoserine; Podosomes; Protein Transport; Receptors, Cytoplasmic and Nuclear; rhoA GTP-Binding Protein; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha | 2018 |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance.
Topics: Adenylate Kinase; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Survival; Disease Progression; Drug Resistance, Neoplasm; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Glycolysis; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; S-Phase Kinase-Associated Proteins; Signal Transduction; Stress, Physiological; Ubiquitination | 2018 |