Compounds > phosphoserine

phosphoserine and alpha-synuclein

phosphoserine has been researched along with alpha-synuclein in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (27.78)29.6817
2010's8 (44.44)24.3611
2020's5 (27.78)2.80

Authors

AuthorsStudies
Fujita, SC; Hasegawa, M; Hirai, Y; Iwatsubo, T1
Franz, KJ; Liu, LL1
Chung, KC; Hasegawa, M; Iwatsubo, T; Kim, EJ; Kim, J; Lee, HJ; Min, do S; Paik, SR; Rhim, H; Sung, JY1
Arai, T; Goedert, M; Hasegawa, M; Hisanaga, S; Ishii, A; Iwatsubo, T; Mann, D; Nonaka, T; Saito, T; Taniguchi, S1
Covy, JP; Giasson, BI; Hurtig, HI; Van Deerlin, VM; Waxman, EA; Yuan, W1
Chen, NH; Du, G; Hu, J; Sun, J; Wang, X; Yuan, Y; Zhao, M1
Gonçalves, S; Outeiro, TF1
Antas, P; Basso, E; Gonçalves, S; Marijanovic, Z; Outeiro, TF; Tenreiro, S1
Churchill, DG; Ha, Y; Kim, K; Lee, S; Liew, H; Park, HS; Suh, YH; Yang, A1
Baekelandt, V; Corti, O; Oliveras-Salvá, M; Van den Haute, C; Van der Perren, A; Van Rompuy, AS1
Ardah, MT; El-Agnaf, OM; Hall, H; Halliday, G; Kirik, D; Landeck, N; Majbour, NK1
Chen, J; Gui, C; Li, W; Mao, K; Ren, Y; Wu, X; Zhao, M; Zou, F1
Arbelo, JM; Castanedes Casey, M; Cornejo-Olivas, M; Dickson, DW; Diehl, NN; Farrer, MJ; Ferrer, I; Fiesel, FC; Graff-Radford, NR; Heckman, MG; Hou, X; Lin, WL; Lorenzo-Betancor, O; Mata, IF; Murray, ME; Ross, OA; Rousseau, LG; Soto, AI; Springer, W; Steele, JC; Tacik, P; Torres, L; Truban, D; Wszolek, ZK1
Hanpude, P; Jangir, D; Kumar, R; Kumar, S; Kumari, R; Maiti, TK; Singh, AK1
Bamodu, OA; Chao, TY; Chau, KD; Chen, KY; Chiu, JY; Hong, CT; Hu, CJ; Wang, W; Wu, D1
Bezard, E; De Giorgi, F; Doudnikoff, E; Faggiani, E; He, X; Ichas, F; Laferrière, F; Meissner, WG; Zinghirino, F1
Dawson, TM; Dawson, VL; Feng, G; Hu, JJ; Jia, C; Jiang, L; Kimura, Y; Li, D; Li, YM; Lim, YJ; Liu, C; Liu, YQ; Liu, Z; Long, H; Ma, MR; Mao, X; Tao, Y; Wang, C; Wang, R; Xu, E; Zhang, S; Zhao, C1
Elsholz, L; Habib, P; Voigt, A; Wasser, Y; Ziegler, P1

Other Studies

18 other study(ies) available for phosphoserine and alpha-synuclein

ArticleYear
Phosphorylated alpha-synuclein in normal mouse brain.
    FEBS letters, 2004, Aug-13, Volume: 572, Issue:1-3

    Topics: Aging; alpha-Synuclein; Animals; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mice; Mice, Inbred C57BL; Models, Biological; Nerve Tissue Proteins; Parkinsonian Disorders; Phosphorylation; Phosphoserine; Stress, Physiological; Synucleins

2004
Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.
    Journal of the American Chemical Society, 2005, Jul-13, Volume: 127, Issue:27

    Topics: alpha-Synuclein; Amino Acid Sequence; Humans; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphotyrosine; Spectrometry, Fluorescence; Synucleins; Terbium; Titrimetry

2005
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.
    The Journal of biological chemistry, 2006, Nov-03, Volume: 281, Issue:44

    Topics: alpha-Synuclein; Cell Survival; Dyrk Kinases; Fibroblast Growth Factor 2; Hippocampus; Humans; Inclusion Bodies; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases

2006
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
    FEBS letters, 2007, Oct-02, Volume: 581, Issue:24

    Topics: Alanine; alpha-Synuclein; Animals; Brain; Casein Kinase II; Epitopes; Heparin; Humans; Mutation; Neurodegenerative Diseases; Phosphoserine; Rats; Tissue Culture Techniques

2007
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
    Movement disorders : official journal of the Movement Disorder Society, 2009, Jan-15, Volume: 24, Issue:1

    Topics: Aged; alpha-Synuclein; Amino Acid Sequence; Cohort Studies; DNA Mutational Analysis; Female; Genes, Dominant; Hippocampus; Humans; Inclusion Bodies; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Neurofibrillary Tangles; Parkinson Disease; Parkinsonian Disorders; Phosphorylation; Phosphoserine; Point Mutation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Temporal Lobe

2009
Overexpression of alpha-synuclein down-regulates BDNF expression.
    Cellular and molecular neurobiology, 2010, Volume: 30, Issue:6

    Topics: alpha-Synuclein; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Luciferases; Models, Biological; NFATC Transcription Factors; PC12 Cells; Phosphorylation; Phosphoserine; Protein Kinase C; Rats

2010
Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.
    Molecular neurobiology, 2013, Volume: 47, Issue:3

    Topics: alpha-Synuclein; Cell Nucleus; Cell Survival; G-Protein-Coupled Receptor Kinase 5; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Light; Microscopy; Mutation; Parkinson Disease; Phosphorylation; Phosphoserine; Protein Transport; Subcellular Fractions

2013
PLK2 modulates α-synuclein aggregation in yeast and mammalian cells.
    Molecular neurobiology, 2013, Volume: 48, Issue:3

    Topics: alpha-Synuclein; Animals; Cell Line; Humans; Inclusion Bodies; Mice; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein Structure, Quaternary; Saccharomyces cerevisiae; Tumor Suppressor Proteins

2013
Facile "stop codon" method reveals elevated neuronal toxicity by discrete S87p-α-synuclein oligomers.
    Biochemical and biophysical research communications, 2014, Jan-17, Volume: 443, Issue:3

    Topics: alpha-Synuclein; Cell Line; Codon, Terminator; Copper; Dopamine; Electrophoresis, Polyacrylamide Gel; Humans; Neurons; Phosphorylation; Phosphoserine; Protein Multimerization; Pyridoxal Phosphate

2014
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.
    Molecular neurodegeneration, 2015, 06-23, Volume: 10

    Topics: alpha-Synuclein; Animals; Cell Count; Cell Line, Tumor; Dependovirus; Dopaminergic Neurons; Female; Genes, Reporter; Genetic Vectors; Humans; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; MicroRNAs; Nerve Degeneration; Neuroblastoma; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Substantia Nigra; Ubiquitin-Protein Ligases

2015
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.
    Molecular neurodegeneration, 2016, 08-22, Volume: 11, Issue:1

    Topics: alpha-Synuclein; Animals; Biological Assay; Brain; Disease Progression; HEK293 Cells; Humans; Lewy Bodies; Mice; Parkinson Disease; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational

2016
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
    Cell death & disease, 2018, 06-13, Volume: 9, Issue:6

    Topics: alpha-Synuclein; Animals; Apoptosis; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Enzyme Activation; Humans; Imidazoles; Mice, Transgenic; Mitochondria; Mitophagy; Mutant Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Phosphoserine; Protein Kinases; Pyridines; Synapses; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases

2018
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.
    Autophagy, 2018, Volume: 14, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; alpha-Synuclein; Biomarkers; Brain; Cohort Studies; Female; HeLa Cells; Humans; Lewy Body Disease; Male; Middle Aged; Mitophagy; Mutation; Phosphorylation; Phosphoserine; Protein Binding; tau Proteins; Ubiquitin

2018
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
    The Journal of biological chemistry, 2020, 03-13, Volume: 295, Issue:11

    Topics: Actin Cytoskeleton; alpha-Synuclein; Amyloid; Animals; Apoptosis; Cell Death; Cell Line, Tumor; Computer Simulation; Cytoskeleton; Deubiquitinating Enzymes; Disease Models, Animal; Endocytosis; Male; Mice, Inbred C57BL; Mitochondria; Models, Biological; Nanostructures; Neurons; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Phosphoserine; Protein Aggregates; Protein Multimerization; Reactive Oxygen Species; Rotenone

2020
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
    Cells, 2020, 03-17, Volume: 9, Issue:3

    Topics: alpha-Synuclein; Animals; Diabetes Mellitus, Type 2; Disease Progression; Dopaminergic Neurons; Genome, Human; Humans; Insulin Resistance; Male; Mice, Inbred C57BL; Mitochondria; Models, Biological; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoserine; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Signal Transduction; Tyrosine 3-Monooxygenase

2020
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.
    Cells, 2020, 10-29, Volume: 9, Issue:11

    Topics: alpha-Synuclein; Amyloid; Animals; Brain; Cells, Cultured; Humans; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Multiple System Atrophy; Myelin Basic Protein; Myelin Proteolipid Protein; Neurons; Oligodendroglia; Parkinson Disease; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Protein Aggregates; Protein Multimerization

2020
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 06-29, Volume: 118, Issue:26

    Topics: alpha-Synuclein; Amyloid; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Cell Line, Tumor; Endocytosis; Humans; Lymphocyte Activation Gene 3 Protein; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Phosphorylation; Phosphoserine; Protein Binding; Static Electricity

2021
CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation.
    Cells, 2021, 10-21, Volume: 10, Issue:11

    Topics: alpha-Synuclein; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Peptides; Phosphorylation; Phosphoserine; Protein Aggregates; Protein Multimerization; Solubility

2021