phosphorylcholine and sphingosine

phosphorylcholine has been researched along with sphingosine in 278 studies

Research

Studies (278)

TimeframeStudies, this research(%)All Research%
pre-19907 (2.52)18.7374
1990's73 (26.26)18.2507
2000's127 (45.68)29.6817
2010's59 (21.22)24.3611
2020's12 (4.32)2.80

Authors

AuthorsStudies
Broekhuyse, RM; Roelfzema, H; Veerkamp, JH1
Bocian, KM; Pagano, RE; Ting, AE; Winiski, AP; Wolf, DE1
Conti, F; Delfini, M; Miccheli, A; Piccolella, E; Ricciolini, R1
Desai, NN; Spiegel, S1
Dressler, KA; Kan, CC; Kolesnick, RN1
Bian, J; Ghosh, TK; Gill, DL1
Hara, A; Sugiyama, E; Taketomi, T; Uemura, K2
Insel, PA; Meier, KE; Slivka, SR1
Callahan, JW; Strasberg, PM1
Hamilton, JA; Maulik, PR; Shipley, GG; Sripada, PK1
Callahan, JW; Gerrie, J; Jones, CS; Shankaran, P1
Hara, A; Taketomi, T1
Bitar, KN; Yamada, H1
Rozengurt, E; Seufferlein, T2
Kondo, Y; Okajima, F1
Berger, A; Rosenthal, D; Spiegel, S1
Farach-Carson, MC; Karin, NJ; Liu, R1
Betto, R; Dettbarn, C; Palade, P; Sabbadini, R; Salviati, G1
Alessenko, AV; Romanenko, EB; Vanyushin, BF1
Casey, G; Mills, GB; Xu, Y1
Breu, J; Eldar, H; Livneh, E; Slack, BE; Wurtman, RJ1
Costa, DJ; Fitz, JG; Huang, LW; Kim, S; Kindman, LA; Lakhani, V; Peters, KG; Sharara, AI1
Hannun, YA1
Ekokoski, E; Törnquist, K1
Kwan-Yeung, L; Wong, K1
Brooker, G; Buckley, NE; Carlson, RO; Desai, NN; Mattie, ME; Olivera, A; Seki, T; Spiegel, S1
Dulaney, JT; Fujii, H; Inagaki, F; Ohta, S; Sugita, M; Suzuki, A; Suzuki, M1
Milstien, S; Spiegel, S1
Ohno, K1
Henry, FA; Nielsen, TB; Spiegel, S; Sun, L; Xu, L1
Demopoulos, CA; Lianos, EA; Zanglis, A1
Jakobs, KH; Laser, KT; Meyer Zu Heringdorf, D; Van Koppen, CJ; Zhang, C1
Higaki, Y; Higuchi, K; Imokawa, G; Kawainami, S; Kawashima, M; Murata, Y; Ogata, J; Tsuchiya, T; Yada, Y1
Field, FJ; Hunninghake, GW; Mallampalli, RK; Mathur, SN; Salome, RG; Warnock, LJ1
Chueh, SH; Huang, WC1
Palade, P; Yasui, K1
Berger, A; Bittman, R; Schmidt, RR; Spiegel, S1
Jarvis, WD; Spangelo, BL1
Brandts, BK; Bünemann, M; Desiderio, DM; Liliom, K; Miller, D; Pott, L; Sun, G; Tigyi, G; Tseng, JL1
Himmel, HM; Jakobs, KH; Meyer zu Heringdrof, D; van Koppen, CJ; Windorfer, B1
Furuya, S; Hirabayashi, Y; Kurono, S1
Anderson, WH; Chung, T; Crilly, KS; Kiss, Z; Mukherjee, JJ1
Betto, R; Dettbarn, C; Glembotski, CC; Kindman, LA; Krown, K; Palade, PT; Pereon, Y; Sabbadini, RA; Salviati, G; Teresi, A; Turcato, F; Yasui, K1
Kondo, Y; Ohwada, S; Okajima, F; Yamada, T1
Bielawska, A; Greenberg, CS; Hannun, YA; Lai, TS; Peoples, KA1
Kiss, Z; Mukherjee, JJ1
Hrelia, S; Orlati, S; Rugolo, M1
Kaida, T; Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T1
Ito, M; Izu, H; Sueyoshi, N1
Grinstein, S; Törnquist, K; Woodside, M1
Banasiak, M; Barańska, J; Czarny, M; Stepkowski, D; Wiktorek-Wójcik, M1
Rodríguez-Fernández, JL; Rozengurt, E2
Furukawa, F; Matsushita, K; Nishimura, K; Takigawa, M; Tokura, Y; Wakita, H1
Berger, A; Cultaro, CM; Segal, S; Spiegel, S1
Crilly, KS; Kiss, Z; Tomono, M1
Himmel, HM; Jakobs, KH; Meyer zu Heringdorf, D; Ravens, U; van Koppen, CJ; Windorfer, B1
Fröde, R; Jakobs, KH; Lass, H; Meyer zu Heringdorf, D; Neumann, E; Niederdräing, N; Van Koppen, CJ1
Hrelia, S; Lorenzini, A; Orlati, S; Porcelli, AM; Rugolo, M1
Chin, TY; Chueh, SH2
Bläckberg, L; Duan, RD; Farooqi, A; Hernell, O; Nilsson, A; Nyberg, L1
Grosman, N1
Chen, PF; Chin, TY; Chueh, SH1
Higuchi, K; Imokawa, G; Kondo, H; Takagi, Y; Yada, Y1
Hrelia, S; Orlati, S; Porcelli, AM; Rugolo, M1
Rodriguez-Lafrasse, C; Vanier, MT1
Angelova, MI; Hristova, N; Tsoneva, I1
Calcerrada, MC; Catalan, RE; Martinez, AM; Miguel, BG2
Björklund, S; Ekokoski, E; Nikmo, A; Törnquist, K; Vainio, M1
Gonda, K; Okamoto, H; Shigematsu, H; Takuwa, N; Takuwa, Y; Yatomi, Y1
Barańska, J; Bobeszko, M; Dygas, A; Sidorko, M1
Barańska, J; Wójcik, M1
Kobayashi, S; Matsuda, M; Matsuzaki, M; Miwa, S; Mizukami, Y; Mogami, K; Ohmura, M; Todoroki-Ikeda, N; Yoshida, K1
Hodgson, DM; Rosenberg, A; Taylor, AN; Zhang, Z1
Furukawa, F; Nishimura, K; Seo, N; Takigawa, M; Tokura, Y; Wakita, H1
Berlin, JR; Imanaga, I; Uehara, A; Yasukochi, M1
Kurabayashi, M; Nagai, R; Okajima, F; Sekiguchi, K; Yokoyama, T1
Hanske, J; Jakobs, KH; Lümmen, G; Meyer zu Heringdorf, D; Rümenapp, U; Virchow, S1
Baudhuin, LM; Damron, DS; Hong, G; Wu, W; Xiao, Y; Xu, Y; Zhu, K1
Kanazawa, T; Kawasaki, T; Kozutsumi, Y; Momoi, M; Nakamura, S; Sabe, H; Takematsu, H; Yamaji, T; Yamamoto, A; Yano, H1
Bender, K; Brandts, B; Bünemann, M; Desiderio, DM; Liliom, K; Miller, D; Nusser, N; Pott, L; Sun, G; Tigyi, G1
Boguslawski, G; English, D; Harvey, KA; Kovala, AT; Lyons, D1
Kon, J; Murata, N; Okajima, F; Sato, K; Tomura, H1
Bischoff, A; Czyborra, P; Fetscher, C; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC1
Bischoff, A; Czyborra, P; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC1
Hokazono, Y; Kobayashi, S; Kusuda, T; Miyake, T; Mizukami, Y; Mogami, K; Sato, M; Suzuki, S; Todoroki-Ikeda, N; Yamagata, H; Yamamoto, K1
Assmann, G; Fobker, M; Höbbel, G; Junker, R; Nofer, JR; Seedorf, U; Tepel, M; von Eckardstein, A; Voss, R; Walter, M; Wolinska, I; Zidek, W1
Bittman, R; Verbicky, CA1
Hitomi, K; Ikura, K; Maki, M; Yamagiwa, Y; Yamanishi, K1
Allessie, MA; Brandts, B; Trappe, HJ; Tüttelmann, F; Van Bracht, M1
Alemany, R; Jakobs, KH; Kuchar, I; Lass, H; Lipinski, M; Meyer zu Heringdorf, D; Rümenapp, U1
Baker, DL; Bender, K; Brandts, B; Bünemann, M; Desiderio, DM; Eickel, A; Fabian, MJ; Liliom, K; Malik, KU; Miller, DD; Nusser, N; Pott, L; Sun, G; Tigyi, G; Virág, T; Wang, DA1
Eu, JP; Greenberg, CS; Hausladen, A; Lai, TS; Slaughter, TF; Stamler, JS1
Lynch, KR; Macdonald, TL1
Baudhuin, LM; Hong, G; Mok, SC; Morrison, BH; Schwartz, BM; Wu, W; Xiao, YJ; Xu, Y1
Assmann, G; Fobker, M; Junker, R; Levkau, B; Nofer, JR; Seedorf, U; von Eckardstein, A; Wolinska, I1
Carson, MJ; Lo, D1
Kabarowski, JH; Le, LQ; Witte, ON; Xu, Y; Zhu, K1
Baudhuin, LM; Cristina, KL; Hong, G; Kabarowski, JH; Williams, FS; Witte, ON; Xu, Y; Zhu, K1
Higuchi, K; Ichikawa, Y; Imokawa, G; Kawashima, M; Kondo, H; Takagi, Y; Yada, Y1
Karin, NJ; Lyons, JM1
de Pietri Tonelli, D; Grohovaz, F; Schnurbus, R; Zacchetti, D1
Han, SS; Lee, M1
Baldini, G; Borgatti, P; Bortul, R; Capitani, S; Martelli, AM; Neri, LM; Tabellini, G1
Xu, Y1
Himmel, HM; Jakobs, KH; Meyer zu Heringdorf, D1
Somlyo, AV1
Haze, K; Kashiwagi, S; Kobayashi, S; Kuriyama, S; Kurokawa, T; Miwa, S; Mizukami, Y; Mogami, K; Nakao, F; Sato, M; Shirao, S; Suzuki, M; Todoroki-Ikeda, N1
Kim, J; Lee, T; Sohn, U1
Ito, M; Kobayashi, S; Matsuzaki, M; Miwa, S; Mizukami, Y; Mogami, K; Nakao, F; Shirao, S; Todoroki-Ikeda, N1
Arikawa, J; Imokawa, G; Ishibashi, M; Kawashima, M; Okamoto, R; Takagi, Y1
Altmann, C; Czyborra, P; Hein, P; Michel, MC; Steenpass, V1
Lee, JH; Ogawa, H; Park, JK; Piao, YJ; Seo, EY; Suhr, KB; Tsuboi, R1
Altmann, C; Böyükbas, D; Haude, M; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC1
Hermans-Borgmeyer, I; Ignatov, A; Joost, P; Kreienkamp, HJ; Lintzel, J; Methner, A; Schaller, HC; Thomsen, S1
Berlin, JR; Kobayashi, S; Uehara, A; Yasukochi, M1
Brailoiu, E; Dun, NJ; Patel, S1
Brailoiu, E; Dun, NJ1
Arikawa, K; Kitayama, J; Nagawa, H; Sugimoto, N; Takehara, K; Takuwa, N; Takuwa, Y; Yamaguchi, H1
Adler, G; Beil, M; Eggermann, J; Gern, U; Micoulet, A; Omary, MB; Paschke, S; Seufferlein, T; Spatz, J; Van Veldhoven, PP; von Wichert, G; Waltenberger, J; Walther, P; Wolff-Hieber, E1
DAWSON, RM1
Aoki, J; Bandle, RW; Clair, T; Koh, E; Liotta, LA; Mills, GB; Nam, SW; Ptaszynska, MM; Schiffmann, E; Stracke, ML1
Higuchi, K; Ichikawa, Y; Imokawa, G; Kawashima, M1
Ikari, S; Matsuda, H; Ochi, S; Oda, M; Sakurai, J1
Deguchi, H; Griffin, JH; Yegneswaran, S1
Gotoh, E; Hanada, K; Miura, Y; Nara, F; Nishijima, M1
Michalak, K; Teisseyre, A1
Bittman, R; Li, Z; Mintzer, E1
Chae, EK; Kim, CD; Kye, KC; Lee, JH; Park, JK; Park, S; Piao, YJ; Suhr, KB1
Aksu, B; Altinok, G; Bingol-Kologlu, M; Dindar, H; Fitoz, S; Gokcora, IH; Renda, N; Yagmurlu, A1
Kostenis, E1
Murakami, N; Okuno, T; Shimizu, T; Yokomizo, T1
Fetscher, C; Hedemann, J; Michel, MC1
Im, DS; Jeon, ES; Kang, YJ; Kim, HS; Kim, JH; Kim, YK; Ryu, SH; Song, HY1
Bassa, BV; Ganji, SH; Kamanna, VS; Roh, DD1
Aoki, J; Arai, H; Kakehi, Y; Natori, Y; Nishikawa, K; Sakagami, H1
Kim, CD; Kim, JM; Kye, KC; Lee, CH; Lee, JH; Park, JK; Piao, YJ; Seo, YJ; Suhr, KB; Zhu, MJ1
Anand-Apte, B; Cristina, K; Ebrahem, Q; Jiang, Y; Kim, KS; Lum, H; Qiao, J; Ren, J; Taylor, KL; Tipps, R; Xiao, YJ; Xu, Y1
Jeon, ES; Jung, JS; Kang, YJ; Kim, JH; Kim, YK; Song, HY; Woo, JS1
Bittman, R; Lu, X1
Chen, YY; Kim, CD; Kwon, YB; Kye, KC; Lee, JH; Lee, S; Lee, WH; Lim, JS; Park, JK; Seo, YJ; Suhr, KB; Zhu, MJ1
Aaronson, PI; Leach, RM; Patel, R; Snetkov, VA; Thomas, GD; Ward, JP1
Damaj, BB; Jin, Y; Maghazachi, AA1
Schubert, R1
Harzer, K; Keulemans, JL; Ledvinova, J; Mengel, E; Santer, R; Schoonderwoerd, K; van Diggelen, OP; Voznyi, YV; Zschiesche, M1
Damirin, A; Hashimoto, K; Komachi, M; Kon, J; Mogi, C; Okajima, F; Sato, K; Tobo, M; Tomura, H; Wang, JQ1
Im, DS1
Bae, YC; Jeon, ES; Jung, JS; Kim, JH; Kim, MR; Moon, HJ; Song, HY1
Alewijnse, AE; Michel, MC1
Mathieson, FA; Nixon, GF1
Fujiwaki, T; Kobayashi, H; Murakami, Y; Shimada, T; Takahashi, N; Tasaka, M; Yamaguchi, S1
Afrasiabi, E; Blom, T; Ekokoski, E; Törnquist, K; Tuominen, RK1
Bischoff, A; Czyborra, C; Michel, MC1
Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Ryu, SK1
Huh, CH; Kim, DS; Kwon, SB; Park, ES; Park, KC; Park, SH; Youn, SW1
Hemmings, DG1
Beil, M; Dao, M; Lim, CT; Micoulet, A; Mills, JP; Seufferlein, T; Spatz, J; Suresh, S1
Esato, K; Guo, F; Hamano, K; Kishi, H; Kobayashi, S; Morikage, N; Sato, M; Shirao, S; Soma, M; Yano, T1
Dammer, E; Sewer, MB; Urs, AN1
Brown, DL; Kohama, K; Kumagai, H; Li, S; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Yoshiyama, S1
Adler, G; Beil, M; Busch, T; Kleger, A; Liebau, S; Paschke, S; Prelle, K; Rolletschek, A; Seufferlein, T; Wobus, A; Wolf, E1
Bae, YS; Lee, HY; Shin, EH1
Katayama, T; Kohama, K; Nakamura, A; Tanaka, H; Wang, HH; Yoshiyama, S1
Bae, YC; Jeon, ES; Jung, JS; Kim, JH; Kim, YM; Lee, MJ; Moon, HJ; Song, HY1
Brahmbhatt, VV; Ford, DA; Frank, EC; Hsu, FF; Kao, JL1
Jeon, ES; Kim, JH; Lee, MJ; Sung, SM1
Back, SJ; Kim, CD; Kwon, YB; Lee, JH; Lee, YS; Park, JK; Piao, YJ; Seo, YJ; Sohn, KC; Suhr, KB1
Ceballos, A; Geffner, J; Maggini, J; Martínez, D; Nahmod, K; Sabatté, J; Salamone, G; Salomón, H; Vermeulen, M1
Alewijnse, AE; Jongsma, M; Michel, MC; Mulders, AC; Peters, SL1
Kajiya, K; Kawamichi, H; Kishi, H; Kobayashi, S1
Damirin, A; Kimura, T; Komachi, M; Kurose, H; Liu, JP; Mogi, C; Murata, N; Okajima, F; Sato, K; Tobo, M; Tomura, H; Wang, JQ1
Jeon, ES; Kim, JH; Kim, YM; Lee, MJ; Moon, HJ; Oh, CK1
Eberhardt, W; Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C1
Afrasiabi, E; Balthasar, S; Blom, T; Törnquist, K1
Hama, K; Hatano, Y; Kimoto, Y; Kinoshita, H; Matsuda, N; Nakahata, K; Tohyama, S1
Chiulli, N; Codazzi, F; Di Cesare, A; Gravaghi, C; Grohovaz, F; Zacchetti, D1
Fonfria, E; Michel, AD1
Hashiba, Y; Imai, H; Saito, N; Sasaki, T; Shimizu, T; Tosaka, M1
Arioka, M; Cheon, SH; Ikeno, Y; Kitamoto, K; Konno, N; Nakamura, A1
Kajiya, K; Kawamichi, H; Kishi, H; Kobayashi, S; Takada, Y; Xu, D2
Kovacs, E; Liliom, K1
Ha, NC; Han, M; Im, DS; Jo, JY; Kim, HL; Kim, K; Kim, YL; Sacket, SJ1
Hunter, I; Mathieson, FA; Nixon, GF1
Li, Y; Michel, MC; Mulders, AC; Nau, S1
Aaronson, PI; Knock, GA; Leach, RM; Shaifta, Y; Snetkov, VA; Teague, B; Thomas, GD; Ward, JP1
Abdelrahman, M; Benetti, E; Collino, M; Cuzzocrea, S; Fantozzi, R; Gallicchio, M; Mazzon, E; Murch, O; Thiemermann, C1
Im, BO; Kim, YS; Ko, SK; Min, YS; Park, SY; Sohn, UD; Song, HJ; Whang, WK1
Han, ES; Kim, H; Kim, HJ; Kim, JJ; Kim, KM; Koh, JY; Lee, CH; Noh, MS; Park, SM1
Ishikawa, R; Katayama, T; Kohama, K; Nakamura, A; Okagaki, T; Qin, X; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Ye, LH; Zhao, T1
Fujiwaki, T; Tasaka, M; Yamaguchi, S1
Fujisawa, H; Kobayashi, S; Kudo, A; Kunitsugu, I; Kurokawa, T; Ogasawara, K; Ogawa, A; Shirao, S; Soma, M; Suzuki, M; Yoneda, H1
Hashimoto, M; Iwamaru, Y; Kitani, H; Sato, M; Sugama, S; Takenouchi, T1
Han, J; Jeon, ES; Kim, JH; Kim, YM; Lee, MJ; Park, WS1
Agudo-López, A; Catalán, E; Fernández, I; Martínez, AM; Miguel, BG; Toboso, I1
Ahn, DS; Choi, SK; Lee, YH1
Gao, Y; Ishikawa, R; Kohama, K; Matsumoto, A; Nakamura, A; Qin, X; Wang, HH; Xie, C; Ye, LH; Yoshiyama, S; Zhang, Y1
Aksu, B; Aktas, C; Civelek, S; Guzel, A; Inan, M; Kanter, M; Umit, H; Uzun, H1
Imokawa, G1
Huwiler, A; Pfeilschifter, J1
Akimura, T; Fujisawa, H; Kashiwagi, S; Kato, S; Kishi, H; Kobayashi, S; Kurokawa, T; Miwa, S; Mogami, K; Ogasawara, K; Ogawa, A; Sato, M; Shirao, S; Soma, M; Suzuki, M; Yumiya, Y1
Asano, S; Hatano, R; Inoue, T; Ito, M; Itonori, S; Shinohara, R; Sugita, M; Yokoi, K1
Andoh, T; Kuraishi, Y; Saito, A1
Adams, EJ; Besra, GS; Chen, X; Cook, ME; Cox, DG; Fox, LM; Gumperz, JE; Hildebrand, WH; Howell, AR; Lockridge, JL; Ndonye, RM; Scharf, L; Trott, DL; Veerapen, N; Wang, X1
Kim, HJ; Kim, KM; Kim, SY; Koh, JY; Lee, CH; Lee, HJ; Noh, MS; Park, MK1
Kovacs, E; Liliom, K; Tóth, J; Vértessy, BG1
Abdollahi, H; DiMuzio, PJ; Harris, LJ; McIlhenny, S; Tulenko, TN; Zhang, P1
Sundh, M; Sutherland, DS; Svedhem, S1
Choi, H; Kim, HJ; Kim, KM; Kim, S; Lee, CH; Noh, M; Shin, JH1
Kim, DS; Kwon, NS; Kwon, SB; Park, KC; Park, SH1
Hunter, I; Mathieson, FA; Nixon, GF; Wirrig, C1
Hatake, K; Kudo, R1
Furuichi, M; Horii, K; Imai, Y; Masuda, H; Oka, A; Omi, K; Sakai, N; Tanimoto, T; Waga, I; Yoshida, Y1
Kovacs, E; Liliom, K; Meissner, G; Pasek, DA; Xu, L1
Kanazawa, T; Kozutsumi, Y; Naito, Y; Okano, M; Takematsu, H; Yamamoto, H1
Chun, J; Echtermeyer, F; Herrgott, I; Herzog, C; Hildebrand, R; Johanning, K; Larmann, J; Levkau, B; Mersmann, J; Müller, FU; Schmitz, M; Theilmeier, G; Winterhalter, M1
Ge, D; Jing, Q; Meng, N; Miao, J; Su, L; Zhang, S; Zhang, Y; Zhao, J1
Bae, YS; Baek, SH; Chung, J; Jung, YS; Kim, HJ; Kim, SD; Kwon, JY; Lee, HY; Lee, SY; Shim, JW1
Cho, H; Kong, JY; Lee, GH; Lee, J; Lee, SJ; Lim, HJ; Myung, CS; Park, WK; Yi, H1
Andoh, T; Haza, S; Kuraishi, Y; Saito, A1
Baek, KJ; Jeong, HS; Kim, DS; Kwon, NS; Lee, SH; Park, KC; Yun, HY1
Kim, SY; Lee, CH; Lee, HJ; Noh, M; Park, MK; Shin, J1
Kim, JH; Kim, KH; Kim, MB; Kim, YM; Ko, HC; Lee, MJ1
Ge, D; Meng, N; Miao, JY; Su, L; Zhang, SL; Zhang, Y; Zhao, J1
Armacki, M; Busch, T; Eiseler, T; Jansen, J; Joodi, G; Omary, MB; Seufferlein, T; Spatz, J; Temme, C; von Wichert, G1
Jeong, HS; Kim, DS; Park, KC1
Chen, L; Hou, Y; Liu, ZH; Luo, YB; Ma, JY; Qi, ST; Schatten, H; Sun, QY; Wang, YP; Wei, Y; Yang, CR; Zhang, QH1
Nakagawara, J; Ogasawara, K; Shirao, S; Suzuki, M; Tominaga, T; Yoneda, H1
Nakahara, H; Sakamoto, S; Shibata, O; Shoyama, Y; Uto, T1
Chuang, WL; Cooper, S; Cox, GF; Keutzer, J; McGovern, MM; Pacheco, J; Zhang, XK1
Fang, QH; Kamio, K; Kawasaki, S; Kim, HJ; Kobayashi, T; Liu, X; Mao, LJ; Rennard, SI; Sugiura, H; Togo, S; Wang, XQ1
Gao, J; Li, W; Liu, P; Miao, J; Yue, H; Zhao, J1
Amraoui, Y; Garzotti, M; Groenen, P; Kolb, SA; Marquardt, T; Marques Lourenço, C; Mengel, E; Morand, O; Reunert, J; Welford, RW1
Fujii, M; Ishihara, H; Kagawa, Y; Koizumi, H; Nomura, S; Oka, F; Owada, Y; Sadahiro, H; Shinoyama, M; Shirao, S; Sugimoto, K; Suzuki, M; Tamechika, M; Yoneda, H1
Aaronson, PI; Knock, GA; Prieto-Lloret, J; Shaifta, Y; Smirnov, SV; Snetkov, VA; Ward, JP1
Aksu, B; Aksu, F; Ayaz, A; Ayvaz, S; Cemek, M; Demirtaş, S; Karaca, T1
Chang, F; Li, WJ; Liu, J; Liu, PP; Miao, JY; Yue, HW; Zhao, J1
Eriksson, JE; Fazeli, E; Goto, H; Hyder, CL; Imanishi, SY; Inagaki, M; Isoniemi, KO; Kemppainen, K; Törnquist, K1
Ogino, T; Yokota, K1
El-Najjar, N; Liebisch, G; Orsó, E; Schmitz, G; Wallner, S1
Gao, D; Guan, J; Guo, Y; Jiang, Y; Liu, H; Wang, Y; Xie, W; Yang, T1
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Kim, SH; Kim, SY; Lee, CH; Lee, H; Park, MK; Park, S1
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Lee, EJ; Park, MK1
Li, W; Liu, H; Liu, P; Yin, D; Zhang, S; Zhao, J1
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Lee, H; Nam, S; Park, MK1
Aksu, B; Aksu, F; Ayvaz, S; Bulur, S; Erman, H; Karaca, T; Keles, N; Unlu, E; Unlu, N; Uzun, H1
Bauer, P; Burlina, A; Coll, MJ; Gissen, P; Goizet, C; Hendriksz, CJ; Kolb, SA; Latour, P; Marquardt, T; Vanier, MT; Welford, RW1
McKean, JS; Nixon, GF; Wilson, HM; Wirrig, C1
Bae, YC; Choi, CW; Lee, JW; Nam, KW; Song, JS1
Kishi, H; Kobayashi, S; Lyu, B; Zhang, M; Zhang, Y1
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Park, MK1
Asfaw, B; Gulinello, ME; Jahnova, H; Kuchar, L; Ledvinova, J; Lugowska, A; Malinova, V; Poupetova, H; Sikora, J1
Baek, S; Cui, L; Jung, SH; Kim, B; Ko, K; Lee, KP; Won, KJ1
Benaim, G; Hernandez-Rodriguez, V; Pinto-Martinez, AK; Rodriguez-Durán, J; Serrano-Martin, X1
Yamawaki, H1
Diaz, GA; Ji, AJ; Jouvin, MH; Lachmann, RH; Nandy, I; Puga, AC; Wasserstein, MP1
Ahrends, R; Borst, O; Coman, C; Gawaz, M; Geue, S; Has, C; Hoffmann, N; Kopczynski, D; Lang, F; Manke, MC; Münzer, P; Peng, B; Sickmann, A1
Brea, RJ; Devaraj, NK; Fuertes, A; Podolsky, KA; Seoane, A1
Ge, D; Liu, HH; Yue, HW; Zhao, J1
Chang, F; Gao, J; Ge, D; Han, L; Li, Y; Liu, HH; Liu, J; Yang, WC; Yu, M; Zhao, J1
Aper, T; Böer, U; Haverich, A; Helms, F; Klingenberg, M; Lau, S; Wilhelmi, M1
Cho, Y; Kwon, OS; Son, J; Woo, JH; Yoon, SS1
Georgiev, G; Maslenkova, L; Momchilova, A; Pankov, R; Skrobanska, R; Stoyanova, T; Tsonchev, Z; Tzoneva, R; Uzunova, V1
Eto, Y; Higaki, K; Iwahori, A; Kato, A; Kikuchi, M; Maekawa, M; Mano, N; Narita, A; Noguchi, A; Ogura, J; Okuyama, T; Sato, T; Sato, Y; Takahashi, T1
Akiyama, K; Eto, Y; Hossain, MA; Igarashi, J; Iwamoto, T; Miyajima, T; Wu, C1
Kong, WH; Li, Y; Lu, CC; Qi, Q; Yang, WC; Yao, YJ; Zhang, TL; Zhao, J1
Alayoubi, A; Auray-Blais, C; Boutin, M; Menkovic, I; Mercier, FE; Rivard, GÉ1
Kong, W; Lu, C; Sun, W; Yao, Y; Zhao, J; Zhou, J1
Bae, YS; Cho, KM; Choi, CY; Kim, H; Kim, HH; Kim, KK; Kim, MK; Lee, HY; Lee, M; Park, JS1
Kitazawa, K; Kubota, Y; Musashi, M; Nagasawa, T; Nagasawa-Shimura, N; Tanaka, K; Yamaguchi, Y1
Kishi, H; Kobayashi, S; Lu, Q; Morita, T; Zhang, Y1
Bae, YS; Cho, KH; Cho, ML; Choi, J; Kim, DS; Kwok, SK; Lee, KH; Na, HS; Park, SH1
Kong, W; Li, Z; Lu, Y; Wang, Z; Zhao, J; Zhou, J1
Chen, H; Chen, K; Chen, L; Hu, Y; Huang, D; Jin, S; Ju, M; Li, R; Liu, L; Luan, C; Wang, Z; Zhang, J; Zhou, X1

Reviews

18 review(s) available for phosphorylcholine and sphingosine

ArticleYear
Sphingolipid metabolites: members of a new class of lipid second messengers.
    The Journal of membrane biology, 1995, Volume: 146, Issue:3

    Topics: Animals; Calcium; Cyclic AMP; Growth Substances; Humans; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Mice; Mitosis; Models, Biological; Phosphatidic Acids; Phosphorylcholine; Protein Kinase C; Rats; Second Messenger Systems; Sphingolipidoses; Sphingolipids; Sphingosine; Transcription Factor AP-1

1995
[Niemann-Pick disease types A and B].
    Nihon rinsho. Japanese journal of clinical medicine, 1995, Volume: 53, Issue:12

    Topics: Animals; Cell Differentiation; Ceramides; Glycoproteins; Humans; Lysosomes; Mice; Mutation; Niemann-Pick Diseases; Phosphorylcholine; Saposins; Signal Transduction; Sphingolipid Activator Proteins; Sphingomyelin Phosphodiesterase; Sphingosine

1995
Tyrosine phosphorylation in the action of neuropeptides and growth factors.
    Essays in biochemistry, 1997, Volume: 32

    Topics: Animals; Cell Adhesion Molecules; Cell Division; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Humans; Lysophospholipids; Neuropeptides; Paxillin; Phosphoproteins; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Sphingosine; Tyrosine

1997
Structure activity relationships of lysophospholipid mediators.
    Prostaglandins & other lipid mediators, 2001, Volume: 64, Issue:1-4

    Topics: Drug Industry; Lysophospholipids; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine

2001
Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.
    Biochimica et biophysica acta, 2002, May-23, Volume: 1582, Issue:1-3

    Topics: Animals; GTP-Binding Proteins; Humans; Lysophosphatidylcholines; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingosine

2002
Sphingosylphosphorylcholine-biological functions and mechanisms of action.
    Biochimica et biophysica acta, 2002, May-23, Volume: 1582, Issue:1-3

    Topics: Animals; Calcium Signaling; GTP-Binding Proteins; Humans; Lysophospholipids; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingosine

2002
Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands.
    Journal of cellular biochemistry, 2004, Aug-01, Volume: 92, Issue:5

    Topics: Amino Acid Sequence; Animals; Humans; Molecular Sequence Data; Phosphorylcholine; Phylogeny; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sequence Homology, Amino Acid; Sphingosine

2004
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
    Histology and histopathology, 2005, Volume: 20, Issue:2

    Topics: Animals; Cell Proliferation; Glomerular Mesangium; Humans; Kidney Diseases; Lysophosphatidylcholines; Lysophospholipids; Models, Biological; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Signal Transduction; Sphingosine

2005
Two ligands for a GPCR, proton vs lysolipid.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:12

    Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Humans; Ligands; Lysophosphatidylcholines; Molecular Sequence Data; Phosphorylcholine; Protons; Psychosine; Receptors, G-Protein-Coupled; Sequence Alignment; Signal Transduction; Sphingosine

2005
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 373, Issue:1

    Topics: Animals; Blood Vessels; Calcium; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Lysophospholipids; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine; Vasoconstriction; Vasodilation

2006
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
    Acta biomaterialia, 2005, Volume: 1, Issue:1

    Topics: Animals; Biomechanical Phenomena; Cell Line, Tumor; Elasticity; Erythrocyte Deformability; Erythrocytes; Gastrointestinal Neoplasms; Humans; In Vitro Techniques; Lysophospholipids; Malaria; Pancreatic Neoplasms; Phosphorylcholine; Plasmodium falciparum; Sphingosine

2005
Vascular effects of sphingolipids.
    Acta paediatrica (Oslo, Norway : 1992), 2007, Volume: 96, Issue:455

    Topics: Humans; Lysophospholipids; Phosphorylcholine; Sphingolipids; Sphingosine; Vasoconstriction; Vasodilation

2007
[Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2007, Volume: 129, Issue:4

    Topics: Animals; Calcium; Cardiovascular Diseases; Cholesterol; Humans; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Muscle, Smooth, Vascular; Phosphorylcholine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fyn; rho-Associated Kinases; Signal Transduction; Sphingosine; src-Family Kinases

2007
The multi-functional role of sphingosylphosphorylcholine.
    Progress in lipid research, 2008, Volume: 47, Issue:1

    Topics: Animals; Blood Vessels; Calcium; Extracellular Signal-Regulated MAP Kinases; Humans; Immune System; Myocardium; Neurons; Phosphorylcholine; Signal Transduction; Skin; Sphingosine

2008
A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
    Journal of dermatological science, 2009, Volume: 55, Issue:1

    Topics: Amidohydrolases; Ceramides; Dermatitis, Atopic; Epidermis; Glucosylceramides; Humans; Phosphorylcholine; Psychosine; Sphingomyelins; Sphingosine

2009
Lipids as targets for novel anti-inflammatory therapies.
    Pharmacology & therapeutics, 2009, Volume: 124, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cannabinoids; Fatty Acids, Unsaturated; Humans; Leukotriene Antagonists; Lipids; Lipoxins; Peroxisome Proliferator-Activated Receptors; Phospholipase A2 Inhibitors; Phosphorylcholine; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sphingolipids; Sphingosine

2009
Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review.
    Molecular genetics and metabolism, 2016, Volume: 118, Issue:4

    Topics: Age of Onset; Bile Acids and Salts; Biomarkers; Carrier Proteins; Cholestanes; Genetic Testing; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Phosphorylcholine; Sphingosine; Vesicular Transport Proteins

2016
Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:12

    Topics: Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Endothelial Cells; Humans; Muscle Cells; Muscle, Smooth, Vascular; Phosphorylcholine; Signal Transduction; Sphingosine

2018

Trials

2 trial(s) available for phosphorylcholine and sphingosine

ArticleYear
A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study.
    World neurosurgery, 2014, Volume: 81, Issue:2

    Topics: Aged; Arachidonic Acid; Cardiovascular Agents; Combined Modality Therapy; Eicosapentaenoic Acid; Female; Humans; Male; Middle Aged; Odds Ratio; Phosphorylcholine; Prospective Studies; rho-Associated Kinases; Signal Transduction; Sphingosine; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial

2014
Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.
    Journal of inherited metabolic disease, 2018, Volume: 41, Issue:5

    Topics: Adult; Biomarkers; Bone Density; Enzyme Replacement Therapy; Female; Hexosaminidases; Humans; Lipids; Liver; Lung; Male; Niemann-Pick Disease, Type A; Phosphorylcholine; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Spleen; Treatment Outcome

2018

Other Studies

258 other study(ies) available for phosphorylcholine and sphingosine

ArticleYear
Lipids in tissues of the eye XI. Synthesis of sphingomyelin in the calf lens.
    Experimental eye research, 1976, Volume: 22, Issue:1

    Topics: Animals; Cattle; Ceramides; Coenzyme A; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Epithelium; Lens, Crystalline; Liver; Microsomes; Phosphatidylcholines; Phosphorylcholine; Rats; Sphingomyelins; Sphingosine; Stearates; Transferases

1976
Determination of the transbilayer distribution of fluorescent lipid analogues by nonradiative fluorescence resonance energy transfer.
    Biochemistry, 1992, Mar-24, Volume: 31, Issue:11

    Topics: 4-Chloro-7-nitrobenzofurazan; Energy Transfer; Fluorescent Dyes; Lipid Bilayers; Liposomes; Lysophospholipids; Models, Molecular; Molecular Structure; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorylcholine; Rhodamines; Spectrometry, Fluorescence; Sphingosine

1992
Modulation of human lymphoblastoid B cell line by phorbol ester and sphingosine. A 31P-NMR study.
    Biochimica et biophysica acta, 1991, Jun-07, Volume: 1093, Issue:1

    Topics: B-Lymphocytes; Cell Division; Cell Line, Transformed; Choline; Energy Metabolism; Enzyme Activation; Herpesvirus 4, Human; Humans; Magnetic Resonance Spectroscopy; Phorbol 12,13-Dibutyrate; Phospholipids; Phosphorylcholine; Protein Kinase C; Sphingosine

1991
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
    Biochemical and biophysical research communications, 1991, Nov-27, Volume: 181, Issue:1

    Topics: 3T3 Cells; Animals; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; HeLa Cells; Humans; Insulin; Kinetics; Mice; Mitogens; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate

1991
Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells.
    The Journal of biological chemistry, 1991, Jun-25, Volume: 266, Issue:18

    Topics: Cell Adhesion; Cell Line; Ceramides; Macrophages; Phosphatidylcholines; Phospholipases; Phosphorylcholine; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate

1991
Intracellular calcium release mediated by sphingosine derivatives generated in cells.
    Science (New York, N.Y.), 1990, Jun-29, Volume: 248, Issue:4963

    Topics: Adenosine Diphosphate; Animals; Calcimycin; Calcium; Cell Line; Kinetics; Phosphoric Monoester Hydrolases; Phosphorylcholine; Protein Kinase C; Second Messenger Systems; Sphingosine; Thermodynamics

1990
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.
    Biochemical and biophysical research communications, 1990, Jun-15, Volume: 169, Issue:2

    Topics: Animals; Cell Division; Cell Line; Choline; Gangliosides; Kinetics; Lipid Metabolism; Mice; Neuroblastoma; Phospholipids; Phosphorylcholine; Psychosine; Sphingosine; Tumor Cells, Cultured

1990
Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.
    The Journal of biological chemistry, 1988, Sep-05, Volume: 263, Issue:25

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cell Membrane; Cytosol; Diglycerides; Dogs; Enzyme Activation; Epinephrine; Hydrolysis; Isoquinolines; Kidney; Kinetics; Neomycin; Phosphatidylcholines; Phosphorylcholine; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Sphingosine

1988
Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, Volume: 66, Issue:12

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Choline; Erythrocytes; Hemolysis; Humans; Intracellular Membranes; Male; Mitochondria, Liver; Mitochondrial Swelling; Niemann-Pick Diseases; Oxygen Consumption; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains; Sphingosine

1988
Partial synthesis and properties of a series of N-acyl sphingomyelins.
    Journal of lipid research, 1987, Volume: 28, Issue:6

    Topics: Acylation; Animals; Brain Chemistry; Calorimetry, Differential Scanning; Cattle; Hydrolysis; Magnetic Resonance Spectroscopy; Phosphorylcholine; Sphingomyelins; Sphingosine; Stereoisomerism; X-Ray Diffraction

1987
Studies on the hydrophobic properties of sphingomyelinase.
    The Biochemical journal, 1981, Jan-01, Volume: 193, Issue:1

    Topics: Chromatography, Affinity; Glycoside Hydrolases; Hydrogen-Ion Concentration; Isoelectric Focusing; Octoxynol; Phosphoric Diester Hydrolases; Phosphorylcholine; Polyethylene Glycols; Sepharose; Sphingomyelin Phosphodiesterase; Sphingosine

1981
Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations.
    Journal of biochemistry, 1983, Volume: 94, Issue:5

    Topics: Acylation; Animals; Choline; Chromatography, Gas; Hydrolysis; Molecular Conformation; Phosphorylcholine; Sphingosine; Spinal Cord; Stereoisomerism; Swine; Type C Phospholipases

1983
Modulation of smooth muscle contraction by sphingosylphosphorylcholine.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 1

    Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Digestive System; Digestive System Physiological Phenomena; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gastrointestinal Motility; Immunoblotting; Muscle, Smooth; Phosphorylcholine; Protein Kinase C; Rabbits; Sphingosine

1995
Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
    The Journal of biological chemistry, 1995, Oct-13, Volume: 270, Issue:41

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cytochalasin D; DNA; DNA Replication; Egtazic Acid; Enzyme Activation; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphorylcholine; Protein Kinase C; Proteins; Sphingosine; Thymidine; Virulence Factors, Bordetella

1995
Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway.
    The Journal of biological chemistry, 1995, Oct-13, Volume: 270, Issue:41

    Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Blotting, Western; Bombesin; Botulinum Toxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Indoles; Kinetics; Maleimides; Mice; Microinjections; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylcholine; Phosphotyrosine; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Signal Transduction; Sphingosine

1995
Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
    The Journal of biological chemistry, 1995, Nov-03, Volume: 270, Issue:44

    Topics: Calcium; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; HL-60 Cells; Humans; Kinetics; Lysophospholipids; Neutrophils; Pertussis Toxin; Phosphorylcholine; Platelet Activating Factor; Psychosine; Pyrrolidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingomyelin Phosphodiesterase; Sphingosine; Type C Phospholipases; Uridine Triphosphate; Virulence Factors, Bordetella

1995
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jun-20, Volume: 92, Issue:13

    Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Division; Cell Nucleus; DNA; DNA-Binding Proteins; Humans; Male; Mice; Molecular Sequence Data; Niemann-Pick Diseases; Oligodeoxyribonucleotides; Phosphorylcholine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Salmon; Signal Transduction; Spermatozoa; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection

1995
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores.
    Biochemical and biophysical research communications, 1995, Sep-14, Volume: 214, Issue:2

    Topics: 3T3 Cells; Animals; Calcium; Fluorescent Dyes; Fura-2; Kinetics; Lysophospholipids; Mice; Osteoblasts; Phosphorylation; Phosphorylcholine; Psychosine; Sphingosine; Structure-Activity Relationship

1995
Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes.
    Brain research, 1995, Jan-09, Volume: 669, Issue:1

    Topics: Animals; Brain; Calcium; Calcium Channels; Cattle; Cerebellum; Microsomes; Muscle Proteins; Palmitoyl Coenzyme A; Phosphorylcholine; Quaternary Ammonium Compounds; Ryanodine Receptor Calcium Release Channel; Sphingosine

1995
Effect of sphingomyelin and antioxidants on the in vitro and in vivo DNA methylation.
    Biochemistry and molecular biology international, 1995, Volume: 35, Issue:1

    Topics: Animals; Antioxidants; Base Composition; Butylated Hydroxytoluene; Cattle; Cell Nucleus; DNA; Methionine; Methylation; Nucleotides; Octoxynol; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Rats; Sphingomyelins; Sphingosine; Thymus Gland; Tritium

1995
Effect of lysophospholipids on signaling in the human Jurkat T cell line.
    Journal of cellular physiology, 1995, Volume: 163, Issue:3

    Topics: Calcium; Cell Division; Cell Line; Humans; Interleukin-2; Intracellular Membranes; Lysophospholipids; Osmolar Concentration; Phosphorylcholine; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Sphingosine; T-Lymphocytes

1995
Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha.
    The Biochemical journal, 1995, Jan-15, Volume: 305 ( Pt 2)

    Topics: 3T3 Cells; Animals; Biological Transport; Blotting, Western; Carbon Radioisotopes; Choline; Dose-Response Relationship, Drug; Isoenzymes; Isotope Labeling; Mice; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate

1995
Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel.
    The Journal of biological chemistry, 1995, Mar-10, Volume: 270, Issue:10

    Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Endothelium, Vascular; Female; Heparin; Humans; In Vitro Techniques; Ion Channel Gating; Kinetics; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphorylcholine; RNA, Messenger; Sphingolipids; Sphingosine; Time Factors; Xenopus laevis

1995
Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine.
    Biochimica et biophysica acta, 1994, Mar-10, Volume: 1221, Issue:1

    Topics: Cell Line; Cytosol; Humans; Molecular Structure; Phosphoproteins; Phosphorylcholine; Protein Kinases; Sphingosine; T-Lymphocytes; Tumor Cells, Cultured

1994
Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells.
    The Biochemical journal, 1994, Apr-01, Volume: 299 ( Pt 1)

    Topics: Animals; Arachidonic Acid; Biological Transport; Calcium; Cell Division; Cells, Cultured; Mitogens; Pertussis Toxin; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Thyroid Gland; Virulence Factors, Bordetella

1994
Sphingosine mobilizes intracellular calcium in human neutrophils.
    Cell calcium, 1993, Volume: 14, Issue:6

    Topics: Biological Transport; Calcium; Cell Compartmentation; Cell Death; Dose-Response Relationship, Drug; Edetic Acid; Fluorescent Dyes; Fura-2; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Ionomycin; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylcholine; Saponins; Sphingosine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1993
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.
    The Journal of cell biology, 1993, Volume: 121, Issue:6

    Topics: 3T3 Cells; Animals; Arachidonic Acid; Calcium; Cell Division; Cyclic AMP; Growth Substances; Lysophospholipids; Mice; Phosphatidylinositols; Phosphorylcholine; Protein Kinase C; Signal Transduction; Sphingosine

1993
Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells.
    Journal of biochemistry, 1993, Volume: 113, Issue:4

    Topics: Animals; Cell Differentiation; Mice; Neurites; Neuroblastoma; Phosphorylcholine; Protein Kinase C; Sphingosine; Tritium; Tumor Cells, Cultured

1993
Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi.
    Biochimica et biophysica acta, 1995, Dec-07, Volume: 1259, Issue:3

    Topics: Animals; Carbohydrate Conformation; Carbohydrate Sequence; Ceramides; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids; Glycolipids; Glycosphingolipids; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Oligochaeta; Oligosaccharides; Phosphorylcholine; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Sphingosine

1995
A new wound healing agent--sphingosylphosphorylcholine.
    The Journal of investigative dermatology, 1996, Volume: 106, Issue:2

    Topics: Animals; Cell Division; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphorylcholine; Sphingosine; Time Factors; Wound Healing; Wounds and Injuries

1996
The biological activity of acetylated sphingosylphosphorylcholine derivatives.
    The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:1

    Topics: Acetylation; Adenosine Triphosphate; Animals; Glycogen; Logistic Models; Phosphorylcholine; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Serotonin; Sphingomyelins; Sphingosine; Tetrahymena pyriformis

1996
A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.
    Molecular pharmacology, 1996, Volume: 49, Issue:6

    Topics: Calcium; Cell Division; GTP-Binding Proteins; HL-60 Cells; Humans; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Phosphorylcholine; Sphingosine; Superoxides; Type C Phospholipases

1996
Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency?
    The Journal of investigative dermatology, 1996, Volume: 106, Issue:6

    Topics: Amidohydrolases; Ceramides; Dermatitis, Atopic; Humans; Hydrolysis; Phosphorylcholine; Sphingomyelins; Sphingosine

1996
Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung.
    The Biochemical journal, 1996, Aug-15, Volume: 318 ( Pt 1)

    Topics: Amidohydrolases; Animals; Base Sequence; Betamethasone; Blotting, Southern; Ceramidases; Choline-Phosphate Cytidylyltransferase; Cycloserine; Glucocorticoids; Kinetics; Lung; Male; Molecular Sequence Data; Nucleotidyltransferases; Phospholipids; Phosphorylcholine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Up-Regulation

1996
Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum.
    Brain research, 1996, Apr-29, Volume: 718, Issue:1-2

    Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Cerebellum; In Vitro Techniques; Male; Membranes; Microsomes; Mitochondria; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sphingosine; Tumor Cells, Cultured

1996
Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 1

    Topics: Animals; Calcium; Electric Conductivity; Myocardium; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sodium; Sphingosine; Ventricular Function

1996
Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.
    Molecular pharmacology, 1996, Volume: 50, Issue:3

    Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Division; Consensus Sequence; DNA; Lysophospholipids; Mice; Molecular Sequence Data; Phosphorylcholine; Sphingolipids; Sphingosine; Structure-Activity Relationship; Transcription Factor AP-1

1996
Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro.
    Endocrinology, 1996, Volume: 137, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lysophosphatidylcholines; Male; Phenanthridines; Phosphorylcholine; Pituitary Gland, Anterior; Platelet Activating Factor; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine

1996
A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.
    The EMBO journal, 1996, Oct-15, Volume: 15, Issue:20

    Topics: Animals; Electrophysiology; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guinea Pigs; Heart Atria; Lysophospholipids; Magnetic Resonance Spectroscopy; Models, Molecular; Pertussis Toxin; Phosphorylcholine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Virulence Factors, Bordetella

1996
Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:4

    Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; GTP-Binding Proteins; Lysophospholipids; Pertussis Toxin; Phospholipases; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingolipids; Sphingosine; Virulence Factors, Bordetella

1996
Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes.
    Journal of lipid mediators and cell signalling, 1996, Volume: 14, Issue:1-3

    Topics: Animals; Brain; Calcium; Fluorescent Dyes; Fura-2; Ion Transport; Microsomes; Phosphorylcholine; Rats; Rats, Wistar; Signal Transduction; Sphingosine

1996
ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate.
    The Journal of biological chemistry, 1997, Jan-31, Volume: 272, Issue:5

    Topics: 3T3 Cells; Adenosine Triphosphate; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; DNA; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Harvey murine sarcoma virus; Immunosuppressive Agents; Insulin; Kinetics; Lysophospholipids; Mice; Models, Biological; Phosphatidylinositol 3-Kinases; Phospholipases A; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Sphingosine; Thymidine; Transfection; Wortmannin

1997
Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes.
    The Biochemical journal, 1997, Feb-15, Volume: 322 ( Pt 1)

    Topics: Animals; Calcium; Calcium Channels; Dogs; Dose-Response Relationship, Drug; Intracellular Membranes; Microsomes; Muscle Proteins; Myocardium; Phosphorylcholine; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sphingosine

1997
Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions.
    Cellular and molecular life sciences : CMLS, 1997, Volume: 53, Issue:5

    Topics: 3T3 Cells; Animals; Cattle; Cell Culture Techniques; Cell Cycle; Cell Division; Ceramides; DNA; Humans; Lysophospholipids; Mice; Nucleic Acid Synthesis Inhibitors; Pancreatic Neoplasms; Phosphorylcholine; Serum Albumin; Sphingosine; Tumor Cells, Cultured

1997
Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
    The Journal of biological chemistry, 1997, Jun-27, Volume: 272, Issue:26

    Topics: Calcium; Enzyme Activation; Factor XIII; Guanosine Triphosphate; Humans; Phosphorylcholine; Sphingosine; Transglutaminases; Trypsin

1997
Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism.
    FEBS letters, 1997, Jul-21, Volume: 412, Issue:1

    Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Drug Synergism; Epidermis; Ethanolamine; Ethanolamines; Lysophospholipids; Mice; Mitogens; Phosphorylcholine; Sphingosine

1997
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism.
    Biochimica et biophysica acta, 1997, Aug-21, Volume: 1358, Issue:1

    Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Cell Line; Humans; Inositol Phosphates; Lysophospholipids; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella

1997
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
    The Journal of biological chemistry, 1997, Oct-03, Volume: 272, Issue:40

    Topics: 3T3 Cells; Animals; Bridged-Ring Compounds; Choline; Diglycerides; Enzyme Activation; Homeostasis; Inositol Phosphates; Interleukin-6; Kinetics; Lysophospholipids; Mice; Norbornanes; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase C; Sphingosine; Thiocarbamates; Thiones; Tumor Necrosis Factor-alpha; Type C Phospholipases

1997
Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589.
    Journal of lipid research, 1997, Volume: 38, Issue:9

    Topics: Amidohydrolases; Chromatography, Thin Layer; Gram-Negative Facultatively Anaerobic Rods; Magnetic Resonance Spectroscopy; Phosphorylcholine; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine; Stereoisomerism

1997
Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells.
    European journal of biochemistry, 1997, Sep-01, Volume: 248, Issue:2

    Topics: Amiloride; Animals; Anti-Bacterial Agents; Cells, Cultured; Deoxyglucose; Hydrogen; Hydrogen-Ion Concentration; Macrolides; Nigericin; Ouabain; Phosphorylcholine; Pituitary Gland; Polymerase Chain Reaction; Rats; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine

1997
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
    Biochemical and biophysical research communications, 1997, Dec-08, Volume: 241, Issue:1

    Topics: Animals; Cholesterol Esters; Glioma; Kinetics; Microsomes; Microsomes, Liver; Nitrogenous Group Transferases; Phosphatidylserines; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured

1997
Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes.
    The Journal of investigative dermatology, 1998, Volume: 110, Issue:3

    Topics: Animals; Calcium; Cell Division; Cell Membrane; Cells, Cultured; Diabetes Mellitus; DNA; Female; Humans; Intracellular Membranes; Keratinocytes; Mice; Mice, Inbred C57BL; Phosphorylcholine; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Skin; Sphingosine; Urokinase-Type Plasminogen Activator; Wound Healing; Wounds, Penetrating

1998
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein.
    Biochimica et biophysica acta, 1998, Feb-16, Volume: 1390, Issue:2

    Topics: 3T3 Cells; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Leucine Zippers; Mice; Mitogens; Nuclear Proteins; Phosphorylation; Phosphorylcholine; Protein Binding; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sphingosine; Temperature; Transcription Factors; Upstream Stimulatory Factors

1998
The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation.
    Archives of biochemistry and biophysics, 1998, Apr-01, Volume: 352, Issue:1

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Choline Kinase; DNA; Drug Interactions; Enzyme Inhibitors; Fibroblast Growth Factors; Hemicholinium 3; Insulin; Kinetics; Lysophospholipids; Mice; Mitogens; Phosphorylcholine; Sphingosine

1998
Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.
    Molecular pharmacology, 1998, Volume: 53, Issue:5

    Topics: Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Guanine Nucleotides; Humans; Insulinoma; Lysophospholipids; Phosphorylcholine; Potassium Chloride; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Sphingosine; Tumor Cells, Cultured

1998
Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells.
    The Journal of biological chemistry, 1998, Jul-24, Volume: 273, Issue:30

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Bombesin; Calcium; Cell Adhesion Molecules; Cytochalasin D; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lysophospholipids; Mice; Molecular Sequence Data; Phosphorylcholine; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Vasopressins

1998
Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine.
    European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1

    Topics: Animals; Binding Sites; Calcium; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Endothelium, Vascular; Humans; Kidney; Phosphorylcholine; Receptors, Cell Surface; Saponins; Sphingolipids; Sphingosine; Stereoisomerism

1998
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.
    The Biochemical journal, 1998, Sep-15, Volume: 334 ( Pt 3)

    Topics: Arachidonic Acid; Bradykinin; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cell Membrane Permeability; Diglycerides; Epithelial Cells; Humans; Inositol Phosphates; Intracellular Fluid; Phosphatidic Acids; Phospholipids; Phosphorylcholine; Respiratory System; Sphingosine; Thapsigargin

1998
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
    The American journal of physiology, 1998, Volume: 275, Issue:5

    Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; DNA; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Swine; Thapsigargin; Virulence Factors, Bordetella

1998
Digestion of ceramide by human milk bile salt-stimulated lipase.
    Journal of pediatric gastroenterology and nutrition, 1998, Volume: 27, Issue:5

    Topics: Amidohydrolases; Ceramidases; Ceramides; Digestion; Fatty Acids; Humans; Hydrolysis; Milk, Human; Phosphorylcholine; Sphingosine; Sterol Esterase

1998
Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
    Immunopharmacology, 1998, Volume: 40, Issue:2

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Enzyme Inhibitors; Gallic Acid; Imidazoles; Leukocytes; Male; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Staurosporine; Synaptosomes

1998
Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells.
    Kidney international, 1998, Volume: 54, Issue:5

    Topics: Animals; Arachidonic Acid; Calcium; Glomerular Mesangium; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Male; Manganese; Phospholipases A; Phospholipases A2; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine

1998
Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes.
    The Journal of investigative dermatology, 1999, Volume: 112, Issue:1

    Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Keratinocytes; Phosphorylcholine; RNA, Messenger; Sphingosine; Tumor Necrosis Factor-alpha

1999
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells.
    Cell calcium, 1998, Volume: 23, Issue:6

    Topics: Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Epithelial Cells; GTP-Binding Proteins; Histamine; Humans; Inositol Phosphates; Lysophospholipids; Magnesium; Nasal Cavity; Palmitic Acid; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Staurosporine; Thapsigargin; Time Factors; Virulence Factors, Bordetella

1998
Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B.
    Neurochemical research, 1999, Volume: 24, Issue:2

    Topics: Brain; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Liver; Niemann-Pick Diseases; Phosphorylcholine; Sensitivity and Specificity; Sphingosine; Spleen

1999
DNA-induced endocytosis upon local microinjection to giant unilamellar cationic vesicles.
    European biophysics journal : EBJ, 1999, Volume: 28, Issue:2

    Topics: Animals; Cations; Cattle; DNA; Endocytosis; Liposomes; Membrane Lipids; Microinjections; Microscopy, Phase-Contrast; Optics and Photonics; Phosphorylcholine; Sphingosine

1999
Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei.
    Neuroscience research, 1999, Volume: 33, Issue:3

    Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Nucleus; Estrenes; Heparin; In Vitro Techniques; Kinetics; Nimodipine; Phosphorylcholine; Pyrrolidinones; Rats; Sphingosine; Thapsigargin; Type C Phospholipases

1999
Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange.
    Biochemical and biophysical research communications, 1999, May-19, Volume: 258, Issue:3

    Topics: Animals; Base Sequence; Biopolymers; Calcium; Cell Line; DNA Primers; GTP-Binding Proteins; Ion Transport; Phosphorylcholine; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Thyroid Gland

1999
EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16.
    Biochemical and biophysical research communications, 1999, Jun-24, Volume: 260, Issue:1

    Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cyclic AMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Humans; I-kappa B Proteins; Immediate-Early Proteins; Inositol Phosphates; Lysophospholipids; NF-KappaB Inhibitor alpha; Phosphorylcholine; Proprotein Convertases; Protein Kinase C; ras Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Serine Endopeptidases; Signal Transduction; Sphingosine

1999
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells.
    Acta biochimica Polonica, 1999, Volume: 46, Issue:1

    Topics: Brain Neoplasms; Enzyme Activation; Glioma; Lysophospholipids; Phospholipase D; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells.
    Acta biochimica Polonica, 1999, Volume: 46, Issue:1

    Topics: Brain Neoplasms; Glioma; Homeostasis; Lysophospholipids; Phosphorylcholine; Sphingosine; Tumor Cells, Cultured

1999
Sphingosylphosphorylcholine induces cytosolic Ca(2+) elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery.
    FEBS letters, 1999, Sep-03, Volume: 457, Issue:3

    Topics: Animals; Calcium; Calcium Signaling; Cattle; Coronary Vessels; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Phosphorylcholine; Polymethacrylic Acids; Sphingosine; Vasodilation

1999
Lysosphingomyelin prevents behavioral aberrations and hippocampal neuron loss induced by the metabotropic glutamate receptor agonist quisqualate.
    Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:5

    Topics: Animals; Behavior, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Lateral Ventricles; Male; Microtubule-Associated Proteins; Neurons; Phosphorylcholine; Quisqualic Acid; Rats; Rats, Inbred F344; Receptors, Metabotropic Glutamate; Seizures; Sphingosine

1999
Modulation of T-lymphocyte proliferation by exogenous natural ceramides and sphingosylphosphorylcholine.
    The journal of investigative dermatology. Symposium proceedings, 1999, Volume: 4, Issue:2

    Topics: Animals; Cell Division; Cells, Cultured; Ceramides; Concanavalin A; DNA Replication; Female; Mice; Mice, Inbred BALB C; Phosphorylcholine; Sphingosine; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha

1999
Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptor.
    FEBS letters, 1999, Nov-05, Volume: 460, Issue:3

    Topics: Animals; Ion Channel Gating; Myocardium; Phosphorylcholine; Rabbits; Respiratory Burst; Ryanodine Receptor Calcium Release Channel; Sphingosine; Time Factors; Wound Healing

1999
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.
    Circulation research, 1999, Nov-26, Volume: 85, Issue:11

    Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Cell Size; Endothelin-1; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Heart; Hypertrophy; Isoproterenol; MAP Kinase Signaling System; Muscle Proteins; Myocardium; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Protein Processing, Post-Translational; Rats; Sphingosine; Virulence Factors, Bordetella

1999
Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:1

    Topics: Actins; Calcium; Carcinoma; Cell Division; Cell Movement; Cyclic AMP; GTP-Binding Proteins; Humans; Lysophospholipids; Phospholipase D; Phosphorylcholine; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingolipids; Sphingosine; Thrombin; Tumor Cells, Cultured; Type C Phospholipases; Urinary Bladder Neoplasms

2000
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    British journal of pharmacology, 2000, Volume: 129, Issue:7

    Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic AMP; Egtazic Acid; Estrenes; Imidazoles; Ionomycin; Manganese; Muscle, Smooth, Vascular; Phosphorylcholine; Pyrrolidinones; Sphingosine; Staurosporine; Swine; Thapsigargin; Thionucleosides; Thionucleotides; Virulence Factors, Bordetella

2000
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.
    Nature cell biology, 2000, Volume: 2, Issue:5

    Topics: Calcium; Cloning, Molecular; Genes, Reporter; Green Fluorescent Proteins; Humans; Indicators and Reagents; Kidney; Ligands; Luminescent Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Sphingosine; Transfection; Tumor Cells, Cultured

2000
Inhibition of cytokinesis by a lipid metabolite, psychosine.
    The Journal of cell biology, 2000, May-15, Volume: 149, Issue:4

    Topics: Actins; Cell Division; Humans; Leukodystrophy, Globoid Cell; Phagocytosis; Phosphorylcholine; Psychosine; Sphingosine; Tumor Cells, Cultured; U937 Cells

2000
Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate.
    Annals of the New York Academy of Sciences, 2000, Volume: 905

    Topics: Animals; Base Sequence; DNA Primers; Guinea Pigs; Heart Rate; Phosphorylcholine; Potassium Channels; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine

2000
Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis.
    Biochemical and biophysical research communications, 2000, Jun-07, Volume: 272, Issue:2

    Topics: Animals; Aorta; Cattle; Cell Differentiation; Cell Size; Chemotaxis; Down-Regulation; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immediate-Early Proteins; Lymphokines; Lysophospholipids; Neovascularization, Physiologic; Phosphoric Monoester Hydrolases; Phosphorylcholine; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; rho GTP-Binding Proteins; RNA, Messenger; Sphingosine; Suramin; Time Factors; Umbilical Cord; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Virulence Factors, Bordetella

2000
Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay.
    Analytical biochemistry, 2000, Jun-15, Volume: 282, Issue:1

    Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Immediate-Early Proteins; Inhibitory Concentration 50; Kinetics; Lysophospholipids; Male; Phosphorylcholine; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Tissue Distribution; U937 Cells

2000
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indomethacin; Lysophospholipids; Male; Mesenteric Arteries; Nitrendipine; Nitroarginine; Pertussis Toxin; Phosphorylcholine; Psychosine; Rats; Rats, Wistar; Renal Artery; Sphingosine; Vasoconstriction; Vasodilator Agents; Virulence Factors, Bordetella

2000
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Kidney; Lysophospholipids; Male; Mesentery; Pertussis Toxin; Phosphorylcholine; Psychosine; Rats; Rats, Wistar; Renal Circulation; Sphingosine; Splanchnic Circulation; Virulence Factors, Bordetella

2000
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.
    FEBS letters, 2000, Sep-29, Volume: 482, Issue:1-2

    Topics: Amides; Animals; Calcium; Coronary Vessels; Cytosol; Enzyme Inhibitors; Guanosine Triphosphate; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Potassium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Swine

2000
Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux.
    Biochemistry, 2000, Dec-12, Volume: 39, Issue:49

    Topics: Apolipoprotein A-I; Calcium Signaling; Cells, Cultured; Cholesterol; DNA; Egtazic Acid; Enzyme Activation; Estrenes; Fibroblasts; Humans; Lipoproteins, HDL; Lysophospholipids; Mitogens; Nickel; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphorylcholine; Psychosine; Pyrrolidinones; Sphingolipids; Sphingosine; Tangier Disease; Type C Phospholipases

2000
Methanolysis of sphingomyelin. Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine.
    Journal of lipid research, 2000, Volume: 41, Issue:12

    Topics: Kinetics; Magnetic Resonance Spectroscopy; Methane; Phosphorylcholine; Sphingomyelins; Sphingosine; Stereoisomerism; Temperature

2000
Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells.
    Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:10

    Topics: Animals; Baculoviridae; Calcium; Calpain; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanosine Triphosphate; Humans; Hydrolysis; Nitric Oxide; Phosphorylcholine; Recombinant Proteins; Sphingosine; Spodoptera; Transglutaminases

2000
Inhibition of muscarinic potassium current by the class III antiarrhythmic drug RP58866 in guinea-pig atrial myocytes.
    Pacing and clinical electrophysiology : PACE, 2000, Volume: 23, Issue:11 Pt 2

    Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Chromans; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Myocardium; Patch-Clamp Techniques; Phosphorylcholine; Piperidines; Potassium; Receptor, Muscarinic M2; Receptors, Muscarinic; Sphingosine

2000
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.
    European journal of pharmacology, 2001, Mar-02, Volume: 414, Issue:2-3

    Topics: Calcium Signaling; Carbachol; Cell Line; Cholinergic Agonists; DNA-Binding Proteins; GTP-Binding Proteins; Humans; I-kappa B Proteins; Immediate-Early Proteins; Lysophospholipids; NF-KappaB Inhibitor alpha; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Type C Phospholipases

2001
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors.
    The Biochemical journal, 2001, Apr-01, Volume: 355, Issue:Pt 1

    Topics: Animals; Blotting, Western; Carrier Proteins; Heart; Heart Atria; Phosphorylcholine; Precipitin Tests; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sphingosine

2001
Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase.
    Biochemistry, 2001, Apr-24, Volume: 40, Issue:16

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cations, Divalent; Cattle; Cells, Cultured; Cysteine; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Humans; Kinetics; Mercaptoethanol; Nitric Oxide; Nitroso Compounds; Phosphorylcholine; Platelet Aggregation; Protein Conformation; Protein Glutamine gamma Glutamyltransferase 2; Recombinant Proteins; S-Nitrosothiols; Sphingosine; Transglutaminases

2001
Lysophospholipids increase interleukin-8 expression in ovarian cancer cells.
    Gynecologic oncology, 2001, Volume: 81, Issue:2

    Topics: Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lysophospholipids; Ovarian Neoplasms; Phosphorylcholine; RNA, Messenger; Sphingosine; Tumor Cells, Cultured; Up-Regulation

2001
Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.
    The Journal of biological chemistry, 2001, Sep-14, Volume: 276, Issue:37

    Topics: Apoptosis; Arteriosclerosis; Cell Survival; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, HDL; Mitochondria; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Psychosine; Sphingosine

2001
Immunology. The push-me pull-you of T cell activation.
    Science (New York, N.Y.), 2001, Jul-27, Volume: 293, Issue:5530

    Topics: Animals; Antigen Presentation; Antigens; Arteriosclerosis; B-Lymphocytes; Cell Cycle Proteins; Humans; Ligands; Lipoproteins, LDL; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lysophosphatidylcholines; Mice; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sphingosine; T-Lymphocytes

2001
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
    Science (New York, N.Y.), 2001, Jul-27, Volume: 293, Issue:5530

    Topics: Animals; Arteriosclerosis; Calcium; Cell Cycle Proteins; Cell Line; Chemotaxis, Leukocyte; Humans; Jurkat Cells; Ligands; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Phosphorylcholine; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella

2001
Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes.
    Acta neurobiologiae experimentalis, 2001, Volume: 61, Issue:2

    Topics: Animals; Anticoagulants; Calcium; Calcium Channel Blockers; Heparin; Nimodipine; Phosphorylcholine; Psychosine; Rats; Ryanodine; Sphingolipids; Sphingosine; Synaptosomes

2001
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
    The Journal of biological chemistry, 2001, Nov-02, Volume: 276, Issue:44

    Topics: 3T3 Cells; Animals; Base Sequence; Calcium; CHO Cells; Cricetinae; DNA Primers; DNA Replication; Enzyme Activation; Humans; Ligands; Lysophosphatidylcholines; Mice; Mitogen-Activated Protein Kinases; Phosphorylcholine; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sphingosine; Transfection

2001
Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes.
    Journal of lipid research, 2001, Volume: 42, Issue:10

    Topics: Calcium; Cathepsin D; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Humans; Keratinocytes; Phosphorylcholine; RNA, Messenger; Sphingosine; Thymidine; Time Factors; Transglutaminases

2001
A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:11

    Topics: 3T3 Cells; Animals; Base Sequence; Calcium Signaling; DNA, Complementary; GTP-Binding Proteins; Immediate-Early Proteins; Ion Channel Gating; Lysophospholipids; Mice; Molecular Sequence Data; Osteoblasts; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; RNA, Messenger; Sphingolipids; Sphingosine

2001
Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine.
    The Biochemical journal, 2002, Feb-15, Volume: 362, Issue:Pt 1

    Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cell Line; Cricetinae; DNA, Complementary; Dogs; Evaluation Studies as Topic; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylcholine; Protein Conformation; Sphingosine

2002
Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway.
    Cellular signalling, 2002, Volume: 14, Issue:4

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Drug Synergism; Enzyme Activation; Hydrogen Peroxide; Kinetics; Lysophospholipids; Mice; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine

2002
Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells.
    Molecular biology of the cell, 2002, Volume: 13, Issue:3

    Topics: Cell Differentiation; Cell Division; Cell Fractionation; Cell Nucleus; Diglycerides; Dimethyl Sulfoxide; Ethanol; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Isoenzymes; Phospholipase D; Phosphorylcholine; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Solvents; Sphingosine; Tetradecanoylphorbol Acetate

2002
New roads leading to Ca2+ sensitization.
    Circulation research, 2002, Jul-26, Volume: 91, Issue:2

    Topics: Animals; Calcium Signaling; Cattle; Cerebral Arteries; Heterotrimeric GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphorylcholine; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Cell Surface; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Vasospasm, Intracranial

2002
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.
    Circulation research, 2002, Jul-26, Volume: 91, Issue:2

    Topics: Animals; Calcium Signaling; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Cerebral Arteries; Culture Techniques; Enzyme Inhibitors; Escin; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylcholine; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; Sphingosine

2002
Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK.
    Cellular signalling, 2002, Volume: 14, Issue:12

    Topics: Animals; Cats; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Ileum; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phosphorylcholine; Sphingosine

2002
Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway.
    Circulation research, 2002, Nov-15, Volume: 91, Issue:10

    Topics: Acylation; Animals; Blotting, Western; Calcium; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Muscle, Smooth, Vascular; Palmitates; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Wistar; rho-Associated Kinases; Second Messenger Systems; Signal Transduction; Sphingosine; src-Family Kinases; Swine; Vasoconstriction

2002
Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
    Journal of lipid research, 2003, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Ceramides; Dermatitis, Atopic; Epidermis; Humans; Phosphorylcholine; Psychosine; Sphingosine; Up-Regulation

2003
Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine.
    British journal of pharmacology, 2003, Volume: 138, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Microcirculation; Norepinephrine; Phosphorylcholine; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Splanchnic Circulation; Vasoconstriction

2003
Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts.
    Archives of dermatological research, 2003, Volume: 294, Issue:10-11

    Topics: Antibodies; Cells, Cultured; Dermis; Fibroblasts; Fibronectins; Humans; Interleukin-6; Phosphorylcholine; Protein Biosynthesis; RNA, Messenger; Sphingosine; Transcription, Genetic; Up-Regulation

2003
Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.
    British journal of pharmacology, 2003, Volume: 138, Issue:3

    Topics: Blood Platelets; Calcium; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flow Cytometry; Humans; In Vitro Techniques; Phosphorylcholine; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Time Factors; Type C Phospholipases

2003
Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Binding, Competitive; Brain; Cell Differentiation; Cell Division; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Situ Hybridization; Ligands; Mice; Neurons; Oocytes; Phosphorylcholine; Phylogeny; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Sphingosine; Stem Cells; Substrate Specificity; Synapses; Transfection; Xenopus

2003
Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine.
    Pflugers Archiv : European journal of physiology, 2003, Volume: 445, Issue:6

    Topics: Animals; Calcium; Heart; Ion Channel Gating; Kinetics; Lipid Bilayers; Membrane Potentials; Myocardium; Phosphorylcholine; Rabbits; Ryanodine Receptor Calcium Release Channel; Sphingosine

2003
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).
    The Biochemical journal, 2003, Jul-15, Volume: 373, Issue:Pt 2

    Topics: Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Electrophysiology; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Muscles; NADP; Neuromuscular Junction; Neurotransmitter Agents; Phosphorylcholine; Rana pipiens; Sphingosine; Thapsigargin; Wound Healing

2003
Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings.
    Molecular pharmacology, 2003, Volume: 63, Issue:6

    Topics: Animals; Calcium; Carcinogens; Cattle; Drug Carriers; Drug Interactions; Inositol 1,4,5-Trisphosphate; Liposomes; Motor Endplate; Motor Neurons; Nerve Endings; Neurotransmitter Agents; Phosphorylcholine; Rana pipiens; Sphingosine; Thapsigargin

2003
Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.
    The Journal of biological chemistry, 2003, Aug-29, Volume: 278, Issue:35

    Topics: Adenoviridae; Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Movement; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genetic Vectors; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Ligands; Lysophospholipids; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Phosphorylcholine; Plasmids; Protein Isoforms; Pyrazoles; Pyridines; rac GTP-Binding Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Temperature; Time Factors

2003
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
    Nature cell biology, 2003, Volume: 5, Issue:9

    Topics: Actin Cytoskeleton; Carcinoma; Cell Movement; Cell Size; Cytoskeleton; Elasticity; Fluorescent Antibody Technique; Humans; Keratins; Microscopy, Electron; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphorylcholine; Sphingosine; Stress, Mechanical; Tumor Cells, Cultured

2003
The reported occurrence of sphingosylphosphorylcholine in animal tissues.
    The Biochemical journal, 1958, Volume: 68, Issue:2

    Topics: Animals; Choline; Phospholipids; Phosphorylcholine; Sphingosine

1958
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
    Cancer research, 2003, Sep-01, Volume: 63, Issue:17

    Topics: 3T3 Cells; Animals; Catalysis; Cell Movement; Chlorocebus aethiops; COS Cells; Glucose-6-Phosphate Isomerase; Glycoproteins; Hydrolysis; Lysophospholipids; Mice; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylcholine; Pyrophosphatases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; rho GTP-Binding Proteins; Sphingosine

2003
Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes.
    Pigment cell research, 2003, Volume: 16, Issue:6

    Topics: Cell Division; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Humans; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-kit; Receptors, Endothelin; RNA, Messenger; Sphingosine; Stem Cell Factor; Transcription Factors

2003
Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: 4-Aminobenzoic Acid; ADP Ribose Transferases; Amidohydrolases; Animals; Bacterial Toxins; Botulinum Toxins; Calcium-Binding Proteins; Ceramidases; Chromatography, Thin Layer; Diglycerides; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Erythrocytes; Ethanolamines; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hemolysis; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Oleic Acids; para-Aminobenzoates; Pertussis Toxin; Phosphatidylcholines; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Rabbits; Sheep; Sphingomyelins; Sphingosine; Time Factors; Toxins, Biological; Type C Phospholipases

2004
Sphingolipids as bioactive regulators of thrombin generation.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Anticoagulants; Binding Sites; Blood Platelets; Carbon; Dose-Response Relationship, Drug; Down-Regulation; Factor Va; Factor Xa; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Lipid Metabolism; Lipids; Micelles; Phosphorylcholine; Protein Binding; Protein Structure, Tertiary; Prothrombin; Psychosine; Sphingolipids; Sphingosine; Thrombin

2004
Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.
    FEBS letters, 2004, Jan-16, Volume: 557, Issue:1-3

    Topics: Cell Line; Humans; Hydrolysis; Kidney; Kinetics; Molecular Sequence Data; Phospholipids; Phosphorylcholine; Sphingomyelin Phosphodiesterase; Sphingosine; Substrate Specificity; Type C Phospholipases

2004
The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes.
    European biophysics journal : EBJ, 2004, Volume: 33, Issue:6

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ion Channel Gating; Kv1.3 Potassium Channel; Membrane Potentials; Phosphorylcholine; Potassium Channels, Voltage-Gated; Sphingosine; T-Lymphocytes; Zinc

2004
The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine.
    Chemistry and physics of lipids, 2004, Volume: 130, Issue:2

    Topics: Lysophospholipids; Micelles; Molecular Structure; Phosphorylcholine; Sodium Chloride; Sphingosine; Water

2004
Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts.
    The Journal of investigative dermatology, 2004, Volume: 122, Issue:6

    Topics: Animals; Calcium; Cells, Cultured; Dermis; Fibroblasts; Gene Expression; GTP-Binding Proteins; Humans; MAP Kinase Signaling System; Phosphorylcholine; Plasminogen Activator Inhibitor 1; Protein Kinase C; Rabbits; Sphingosine; Wound Healing

2004
A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling.
    Pediatric surgery international, 2004, Volume: 20, Issue:10

    Topics: Animals; Burns, Chemical; Caustics; Collagen; Contrast Media; Disease Models, Animal; Esophageal Stenosis; Esophagus; Female; Hydroxyproline; Mucous Membrane; Muscle, Smooth; Phosphorylcholine; Radiography; Rats; Rats, Wistar; Second Messenger Systems; Sodium Hydroxide; Sphingosine; Treatment Outcome; Wound Healing

2004
G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.
    The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41

    Topics: Actins; Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Line; Cloning, Molecular; COS Cells; Flow Cytometry; Genes, Reporter; Histidine; Humans; Hydrogen-Ion Concentration; Immunoprecipitation; Inositol Phosphates; Ligands; Lysophosphatidylcholines; Mice; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis, Site-Directed; NIH 3T3 Cells; PC12 Cells; Phosphorylcholine; Promoter Regions, Genetic; Protons; Rats; Receptors, G-Protein-Coupled; Sequence Homology, Amino Acid; Signal Transduction; Sphingosine; Time Factors; Transfection

2004
Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries.
    Autonomic & autacoid pharmacology, 2004, Volume: 24, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Lysophospholipids; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Norepinephrine; Phosphorylcholine; Potassium Chloride; Rats; Rats, Wistar; Sphingolipids; Sphingosine; Vasoconstrictor Agents

2004
Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways.
    Cellular signalling, 2005, Volume: 17, Issue:6

    Topics: Animals; Calcium; Cell Line; Chlorocebus aethiops; COS Cells; Endothelial Cells; Phospholipase D; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-delta; Reactive Oxygen Species; Signal Transduction; Sphingosine; Type C Phospholipases

2005
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
    The Journal of biological chemistry, 2005, Jun-17, Volume: 280, Issue:24

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Blotting, Northern; Blotting, Western; Brain; Cations; Cell Membrane; Cell Movement; Fatty Acids; Glycerylphosphorylcholine; HeLa Cells; Humans; Hydrolysis; Immunohistochemistry; Kidney; Kinetics; Lysophosphatidylcholines; Mice; Microscopy, Fluorescence; Models, Biological; Models, Chemical; Molecular Sequence Data; Myocardium; Nephrons; Phospholipids; Phosphoric Diester Hydrolases; Phosphorylcholine; Phylogeny; Protein Binding; Protein Structure, Tertiary; Pyrophosphatases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity; Sphingomyelin Phosphodiesterase; Sphingosine; Swine; Time Factors; Tissue Distribution; Transfection; Type C Phospholipases

2005
Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis.
    Experimental dermatology, 2005, Volume: 14, Issue:5

    Topics: Animals; Aorta; Capillaries; Cell Movement; Cells, Cultured; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Neovascularization, Physiologic; Phosphorylcholine; Rats; Rats, Inbred F344; Sphingosine; Umbilical Veins; Urokinase-Type Plasminogen Activator; Wound Healing

2005
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:7

    Topics: Animals; Antibodies; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chick Embryo; Endothelial Cells; Enzyme Activation; Gene Expression; Humans; Hydrogen-Ion Concentration; Lysophospholipids; Neovascularization, Physiologic; Oncogene Protein v-akt; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; RNA, Small Interfering; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A

2005
Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells.
    Biochimica et biophysica acta, 2005, May-01, Volume: 1734, Issue:1

    Topics: Adipose Tissue; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cytochromes c; Humans; MAP Kinase Signaling System; Phosphorylcholine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sphingosine; Stem Cells

2005
Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue.
    The Journal of organic chemistry, 2005, Jun-10, Volume: 70, Issue:12

    Topics: Carbon Isotopes; Combinatorial Chemistry Techniques; Molecular Structure; Phosphorylcholine; Photochemistry; Sphingosine; Stereoisomerism

2005
Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts.
    Experimental dermatology, 2005, Volume: 14, Issue:7

    Topics: Base Sequence; Cells, Cultured; Connective Tissue Growth Factor; DNA, Complementary; Fibroblasts; Gene Expression; Gene Expression Profiling; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Oligonucleotide Array Sequence Analysis; Phosphorylcholine; RNA, Messenger; Signal Transduction; Skin; Sphingosine

2005
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
    Cardiovascular research, 2005, Oct-01, Volume: 68, Issue:1

    Topics: Amides; Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 1; In Vitro Techniques; Lanthanum; Lysophospholipids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylcholine; Pulmonary Artery; Pyridines; Rats; Sphingosine; Thapsigargin; Type C Phospholipases; Vasoconstriction

2005
Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor.
    European journal of immunology, 2005, Volume: 35, Issue:9

    Topics: Cell Cycle Proteins; Chemotaxis; Diterpenes; Fibrinolytic Agents; Flow Cytometry; Ginkgolides; Humans; Interferon-alpha; Interleukins; Killer Cells, Natural; Lactones; Lymphocyte Activation; Lysophosphatidylcholines; Pertussis Toxin; Phosphorylcholine; Platelet Activating Factor; Receptors, G-Protein-Coupled; Receptors, IgG; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine

2005
Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
    Cardiovascular research, 2005, Oct-01, Volume: 68, Issue:1

    Topics: Amides; Animals; Biological Transport; Calcium; Cell Membrane; Enzyme Activation; G-Protein-Coupled Receptor Kinase 1; Humans; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Sphingosine; Vasoconstrictor Agents

2005
A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:5

    Topics: Blood Chemical Analysis; Ceramides; Chemistry, Clinical; Clinical Enzyme Tests; Diagnosis, Differential; Dose-Response Relationship, Drug; Fibroblasts; Fluorometry; Gene Expression Regulation, Enzymologic; Hexosaminidases; Humans; Hydrolysis; Leukocytes; Mutation; Niemann-Pick Diseases; Phospholipid Ethers; Phosphorylcholine; Protein Binding; Reproducibility of Results; Skin; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Substrate Specificity; Time Factors

2005
Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:2

    Topics: Adenylyl Cyclases; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Inositol Phosphates; Lysophosphatidylcholines; Phosphorylcholine; Psychosine; Receptors, G-Protein-Coupled; Second Messenger Systems; Sphingosine; Transfection; Type C Phospholipases

2005
Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK.
    Journal of lipid research, 2006, Volume: 47, Issue:3

    Topics: Adipose Tissue; Calcium; Cell Proliferation; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophosphatidylcholines; MAP Kinase Kinase 4; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 9; Models, Biological; Pertussis Toxin; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Type C Phospholipases

2006
Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?
    British journal of pharmacology, 2006, Volume: 147, Issue:4

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Lysophospholipids; Male; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine

2006
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.
    British journal of pharmacology, 2006, Volume: 147, Issue:4

    Topics: Animals; Calcium; Cells, Cultured; Cerebral Arteries; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Lysophospholipids; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingolipids; Sphingosine

2006
Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Feb-17, Volume: 832, Issue:1

    Topics: Chromatography, Thin Layer; Fabry Disease; Heart Valves; Humans; Male; Middle Aged; Phosphorylcholine; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sphingosine

2006
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C.
    Cellular signalling, 2006, Volume: 18, Issue:10

    Topics: Boron Compounds; Calcium; Calcium Signaling; Cells, Cultured; Gadolinium; Gene Expression Regulation; Humans; Lysophospholipids; Phosphorylcholine; Protein Isoforms; Protein Kinase C; Protein Transport; Receptors, G-Protein-Coupled; RNA, Messenger; Sphingosine; Thapsigargin; Thymidine; Thyroid Gland; Tritium

2006
Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 373, Issue:1

    Topics: Animals; Blood Pressure; Diuresis; Heart Rate; Indomethacin; Kidney; Lysophospholipids; Male; Natriuresis; Neuropeptide Y; Pertussis Toxin; Phosphorylcholine; Rats; Rats, Wistar; Renal Circulation; Sphingosine

2006
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 373, Issue:1

    Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Myosin Light Chains; Naphthalenes; Phosphorylation; Phosphorylcholine; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sphingosine; Vasoconstriction

2006
Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.
    Pigment cell research, 2006, Volume: 19, Issue:2

    Topics: Antioxidants; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Male; MAP Kinase Signaling System; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Phosphorylcholine; Pigmentation; Pyrones; Ribosomal Protein S6 Kinases, 90-kDa; Sphingosine

2006
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.
    Circulation research, 2006, Aug-04, Volume: 99, Issue:3

    Topics: Animals; Calcium; Cholesterol; Coronary Vessels; Female; Humans; Hypercholesterolemia; Intracellular Signaling Peptides and Proteins; Male; Membrane Microdomains; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Protein Serine-Threonine Kinases; Rabbits; rho-Associated Kinases; Sphingosine

2006
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.
    Endocrinology, 2006, Volume: 147, Issue:11

    Topics: Binding Sites; Binding, Competitive; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Homeodomain Proteins; Humans; Phosphorylcholine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sphingosine; Steroid 17-alpha-Hydroxylase; Steroidogenic Factor 1; Transcription Factors; Transcription, Genetic

2006
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:3

    Topics: Actins; Amides; Animals; Azepines; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Myosin Light Chains; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Pyridines; Signal Transduction; Sphingosine

2006
The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
    Cellular signalling, 2007, Volume: 19, Issue:2

    Topics: Actins; Animals; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Focal Adhesions; Humans; Leukemia, Promyelocytic, Acute; Mice; Phosphorylcholine; Receptors, G-Protein-Coupled; Sphingosine

2007
Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:10

    Topics: Chemotaxis; Dendritic Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Mitogen-Activated Protein Kinases; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine

2006
Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells.
    Journal of pharmacological sciences, 2006, Volume: 102, Issue:3

    Topics: Animals; Cells, Cultured; Collagen; Gels; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Microscopy, Electron; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylcholine; Sphingosine

2006
Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
    Journal of cell science, 2006, Dec-01, Volume: 119, Issue:Pt 23

    Topics: Actins; Cell Differentiation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mesenchymal Stem Cells; Muscle, Smooth; Myocytes, Smooth Muscle; Nuclear Proteins; Phosphorylation; Phosphorylcholine; Serum Response Factor; Signal Transduction; Smad2 Protein; Sphingosine; Stress Fibers; Subcutaneous Fat; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1

2006
Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid.
    Chemistry and physics of lipids, 2007, Volume: 145, Issue:2

    Topics: Aldehydes; Chlorine; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Lipoproteins, HDL; Lysophospholipids; Peroxidase; Phosphorylcholine; Sphingosine

2007
Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK.
    Journal of cellular biochemistry, 2007, Apr-15, Volume: 100, Issue:6

    Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Humans; In Situ Nick-End Labeling; Mice; Nitriles; Phosphorylcholine; Reactive Oxygen Species; Signal Transduction; Sphingosine; Transfection

2007
Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
    Journal of dermatological science, 2007, Volume: 46, Issue:2

    Topics: Animals; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Activation; Epidermis; Fibroblasts; Flavonoids; Humans; Indoles; Interleukin-6; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Rabbits; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Wound Healing

2007
Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12.
    Immunology, 2007, Volume: 121, Issue:3

    Topics: Antigens, CD; B7-2 Antigen; Calcium; CD83 Antigen; Cells, Cultured; Chemotaxis; Dendritic Cells; Endocytosis; HLA-DR Antigens; Humans; Immunoglobulins; Interferon-gamma; Interleukin-12; Interleukin-18; Lymphocyte Culture Test, Mixed; Membrane Glycoproteins; Phosphorylcholine; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine

2007
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
    Cellular signalling, 2007, Volume: 19, Issue:8

    Topics: Cell Line; Cell Line, Tumor; Cyclic AMP; ErbB Receptors; Humans; Hydrogen-Ion Concentration; Ligands; Lysophosphatidylcholines; NFATC Transcription Factors; Phosphorylcholine; Protons; Receptors, G-Protein-Coupled; Serum Response Element; Signal Transduction; Sphingosine

2007
Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells.
    The international journal of biochemistry & cell biology, 2007, Volume: 39, Issue:6

    Topics: Adult; Benzamides; Blotting, Western; Butadienes; Cell Adhesion; Cells, Cultured; Dioxoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibronectins; Gene Expression; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Nitriles; Phosphorylation; Phosphorylcholine; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Smad Proteins; Smad7 Protein; Sphingosine; Transforming Growth Factor beta1

2007
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
    Journal of lipid research, 2007, Volume: 48, Issue:9

    Topics: Animals; Cells, Cultured; Dinoprostone; Interleukin-1beta; Mesangial Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylcholine; Rats; Signal Transduction; Smad Proteins; Sphingosine; Transforming Growth Factor beta

2007
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
    Molecular and cellular endocrinology, 2007, Aug-15, Volume: 274, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; G2 Phase; Humans; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; Thyroid Neoplasms

2007
Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Intracellular Signaling Peptides and Proteins; Methyl Ethers; Phosphorylcholine; Propofol; Protein Serine-Threonine Kinases; rho-Associated Kinases; Sevoflurane; Sphingosine; Swine; Vasoconstriction

2007
Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.
    The European journal of neuroscience, 2007, Volume: 26, Issue:4

    Topics: Animals; Apoptosis; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Microscopy, Video; Necrosis; Nerve Degeneration; Neurotoxicity Syndromes; Niemann-Pick Disease, Type A; Phenotype; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine

2007
Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.
    British journal of pharmacology, 2007, Volume: 152, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Ethidium; Fluorometry; Humans; Interleukin-1beta; Lipids; Lysophosphatidylcholines; Mice; Octoxynol; Palmitoylcarnitine; Phosphorylcholine; Purinergic P2 Receptor Agonists; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X7; Sphingosine; Surface-Active Agents

2007
Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries.
    Neurological research, 2007, Volume: 29, Issue:5

    Topics: Amides; Animals; Basilar Artery; Calcium; Dinoprost; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Myosin Light Chains; Phosphorylation; Phosphorylcholine; Pyridines; Sphingosine; Vasodilation

2007
Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells.
    Biochemical and biophysical research communications, 2007, Dec-07, Volume: 364, Issue:1

    Topics: Animals; Apoptosis; Calcium; Cells, Cultured; Cerebellum; Mice; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylcholine; Rats; Sphingosine

2007
Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts.
    FEBS letters, 2007, Nov-13, Volume: 581, Issue:27

    Topics: Actins; Animals; Fibroblasts; Humans; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Sphingosine; Stress Fibers; Transfection

2007
Sphingosylphosphorylcholine as a novel calmodulin inhibitor.
    The Biochemical journal, 2008, Mar-01, Volume: 410, Issue:2

    Topics: Animals; Brain Chemistry; Calmodulin; Cattle; Liposomes; Micelles; Phosphorylcholine; Signal Transduction; Sphingosine; Tyrosine

2008
Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.
    Prostaglandins & other lipid mediators, 2007, Volume: 84, Issue:3-4

    Topics: Animals; Calcium; Calorimetry; Cattle; Cell Survival; Humans; Jurkat Cells; Membrane Potential, Mitochondrial; Phosphorylcholine; Reactive Oxygen Species; Serum Albumin, Bovine; Sphingosine; T-Lymphocytes

2007
Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines.
    Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:4

    Topics: Apoptosis; Calcium; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Lysophospholipids; Male; Phosphorylcholine; Prostatic Neoplasms; Sphingosine

2007
Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:2

    Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Dinoprost; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Enzyme Inhibitors; Intracellular Membranes; Male; Myocytes, Smooth Muscle; Osmolar Concentration; Phosphorylcholine; Potassium; Protein Kinase C-delta; Pulmonary Artery; Rats; Rats, Wistar; Sphingosine; Vasoconstriction; Vasomotor System

2008
Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat.
    Critical care medicine, 2008, Volume: 36, Issue:2

    Topics: Animals; Apoptosis; Cyclooxygenase 2; Cytokines; Drug Administration Schedule; Endotoxemia; Intercellular Adhesion Molecule-1; Lung; Male; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylcholine; Rats; Rats, Wistar; Sphingosine

2008
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells.
    Archives of pharmacal research, 2007, Volume: 30, Issue:12

    Topics: Animals; Cats; Esophagus; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Muscle Contraction; Myocytes, Smooth Muscle; Phospholipase C beta; Phosphorylcholine; Protein Kinase C; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine

2007
Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Amides; Animals; Antipruritics; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Intradermal; Ketotifen; Male; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Naltrexone; Narcotic Antagonists; Phosphorylcholine; Pruritus; Pyridines; rho-Associated Kinases; Sphingosine

2008
Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:5

    Topics: Actins; Animals; Becaplermin; Cattle; Cell Line; Chemotaxis; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Fluorescent Antibody Technique; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Microscopy, Confocal; Microscopy, Electron; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Subfragments; Myosin Type II; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Conformation; Proto-Oncogene Proteins c-sis; Rats; Sphingosine

2008
Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Jul-15, Volume: 870, Issue:2

    Topics: Child, Preschool; Gaucher Disease; Glucosylceramides; Humans; Liver; Niemann-Pick Diseases; Phosphorylcholine; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingomyelins; Sphingosine; Spleen

2008
Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway.
    Cerebrovascular diseases (Basel, Switzerland), 2008, Volume: 26, Issue:1

    Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Angiography; Cisterna Magna; Disease Models, Animal; Dogs; Eicosapentaenoic Acid; Female; Injections; Male; Phosphorylcholine; Protein Kinase Inhibitors; rho-Associated Kinases; Signal Transduction; Sphingosine; Subarachnoid Hemorrhage; Time Factors; Vasoconstriction; Vasodilator Agents; Vasospasm, Intracranial

2008
Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Jun-15, Volume: 180, Issue:12

    Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Line, Transformed; Down-Regulation; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lysophospholipids; Mice; Mice, Inbred C57BL; Microglia; Phosphorylcholine; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine

2008
A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells.
    Circulation research, 2008, Sep-12, Volume: 103, Issue:6

    Topics: Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Humans; Mesenchymal Stem Cells; Muscle Contraction; Myocytes, Smooth Muscle; Nuclear Proteins; Oncogene Proteins, Fusion; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Trans-Activators

2008
Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C.
    Acta neurobiologiae experimentalis, 2008, Volume: 68, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Cell Line; DNA Fragmentation; Flow Cytometry; Isoenzymes; Mice; Mitochondria; Neurons; Phosphorylcholine; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Subcellular Fractions

2008
Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
    Cardiovascular research, 2009, May-01, Volume: 82, Issue:2

    Topics: Animals; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Lysophospholipids; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphorylation; Phosphorylcholine; Rabbits; rho-Associated Kinases; Sarcoplasmic Reticulum; Signal Transduction; Sphingosine

2009
Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: Actins; Animals; Binding Sites; Cattle; Cell Line; Chemotaxis; Guinea Pigs; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Myosin Type II; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Protein Kinase Inhibitors; Pseudopodia; Rats; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Sphingosine; Transfection

2009
Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats.
    Journal of pediatric surgery, 2009, Volume: 44, Issue:4

    Topics: Analysis of Variance; Animals; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Immunohistochemistry; Ligation; Lipid Peroxidation; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Phosphorylcholine; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Sphingosine

2009
Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:8

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Calibration; Chromatography, High Pressure Liquid; Dogs; Female; Humans; Kinetics; Male; Mass Spectrometry; Middle Aged; Phosphorylcholine; Regression Analysis; Solid Phase Extraction; Sphingosine; Subarachnoid Hemorrhage

2009
Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava.
    Journal of oleo science, 2009, Volume: 58, Issue:9

    Topics: Animals; Ceramides; Chromatography, Thin Layer; Ciona intestinalis; Hydrolysis; Phosphorylcholine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Sphingomyelins; Sphingosine; Type C Phospholipases; Urochordata

2009
Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:12

    Topics: Animals; Calcium; Dermatitis, Atopic; Ganglia, Spinal; Histamine; Histamine H1 Antagonists, Non-Sedating; Injections, Intradermal; Keratinocytes; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Neurons; Phosphorylcholine; Pruritus; Skin; Sphingomyelins; Sphingosine; Terfenadine

2009
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
    PLoS biology, 2009, Volume: 7, Issue:10

    Topics: Antigen Presentation; Antigen-Presenting Cells; Antigens, CD1d; Autoantigens; Cell Line; Cytokines; Humans; Inflammation; Lymphocyte Activation; Lysophosphatidylcholines; Natural Killer T-Cells; Phosphorylcholine; Signal Transduction; Sphingosine

2009
Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice.
    Journal of dermatological science, 2010, Volume: 57, Issue:1

    Topics: Animals; Dermatitis; Dose-Response Relationship, Drug; Ear; Histamine; Inflammation; Mast Cells; Mice; Mice, Inbred ICR; Phosphorylcholine; Skin; Sphingosine; Time Factors

2010
Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.
    The Journal of biological chemistry, 2010, Jan-15, Volume: 285, Issue:3

    Topics: Amino Acid Sequence; Animals; Apoproteins; Binding, Competitive; Calcium; Calcium Signaling; Calmodulin; Cattle; Humans; Intracellular Space; Kinetics; Melitten; Micelles; Molecular Sequence Data; Phosphorylcholine; Protein Structure, Tertiary; Ryanodine Receptor Calcium Release Channel; Spectrometry, Fluorescence; Sphingosine

2010
Differentiation of adult stem cells into smooth muscle for vascular tissue engineering.
    The Journal of surgical research, 2011, Jun-15, Volume: 168, Issue:2

    Topics: Adult Stem Cells; Aged; Aged, 80 and over; Angiotensin II; Blood Vessel Prosthesis; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Calponins; Cell Culture Techniques; Cell Differentiation; Collagen; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocytes, Smooth Muscle; Myosin Heavy Chains; Phenotype; Phosphorylcholine; Sphingosine; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta

2011
Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces.
    Physical chemistry chemical physics : PCCP, 2010, Jan-14, Volume: 12, Issue:2

    Topics: Cholesterol; Lipid Bilayers; Microscopy, Fluorescence; Phosphatidylcholines; Phosphorylcholine; Silicon Dioxide; Sphingosine; Surface Properties; Temperature

2010
Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes.
    Biochemical pharmacology, 2010, Jul-01, Volume: 80, Issue:1

    Topics: Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Keratinocytes; Membrane Proteins; NADPH Oxidase 5; NADPH Oxidases; Phosphorylcholine; Sphingosine

2010
Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:2

    Topics: Animals; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Membrane; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Immunoprecipitation; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Microscopy, Phase-Contrast; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine

2010
Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:1

    Topics: Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Cerebral Arteries; Chemokine CCL2; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Inflammation; Inflammation Mediators; Lysophospholipids; Male; Muscle, Smooth, Vascular; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine; Subarachnoid Hemorrhage; Transcription Factors; Up-Regulation; Vasospasm, Intracranial

2011
[Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery].
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2010, Volume: 45, Issue:3

    Topics: Animals; Drug Synergism; Ethanol; In Vitro Techniques; Male; Phosphorylcholine; Rats; Sphingosine; Vasoconstriction

2010
Development of a sphingosylphosphorylcholine detection system using RNA aptamers.
    Molecules (Basel, Switzerland), 2010, Aug-20, Volume: 15, Issue:8

    Topics: Aptamers, Nucleotide; Base Sequence; Biological Assay; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Phosphorylcholine; Reproducibility of Results; SELEX Aptamer Technique; Sphingosine; Surface Plasmon Resonance

2010
Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms.
    Biochemical and biophysical research communications, 2010, Oct-15, Volume: 401, Issue:2

    Topics: Animals; Calmodulin; Muscle, Skeletal; Permeability; Phosphorylcholine; Rabbits; Ryanodine Receptor Calcium Release Channel; Sphingosine

2010
Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
    Archives of biochemistry and biophysics, 2011, Feb-01, Volume: 506, Issue:1

    Topics: Base Sequence; Calcium; Cell Differentiation; Cell Line; DNA Primers; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Macrophages; MAP Kinase Signaling System; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Psychosine; raf Kinases; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; U937 Cells

2011
Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.
    Mediators of inflammation, 2010, Volume: 2010

    Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Humans; Lipoproteins, HDL; Lysophospholipids; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phosphorylcholine; Rats; Sphingosine

2010
Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells.
    Journal of cellular physiology, 2011, Volume: 226, Issue:11

    Topics: Apoptosis; Autophagy; Cells, Cultured; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Integrin beta4; Phosphorylcholine; Sphingosine; Tumor Suppressor Protein p53; Type C Phospholipases

2011
Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Apr-01, Volume: 186, Issue:7

    Topics: Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Humans; Membrane Lipids; Pertussis Toxin; Phosphorylcholine; Signal Transduction; Sphingosine; Umbilical Veins

2011
Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Down-Regulation; Humans; Lysophospholipids; NF-kappa B; PC12 Cells; Phosphorylcholine; Rats; Sphingosine

2011
Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions.
    Experimental dermatology, 2011, Volume: 20, Issue:11

    Topics: Administration, Topical; Animals; Arachidonate 5-Lipoxygenase; Dermatitis, Atopic; Disease Models, Animal; Leukotriene B4; Mice; Phenylpropionates; Phosphorylcholine; Pruritus; Receptors, Leukotriene B4; Skin; Sphingosine

2011
Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects.
    Journal of biomedical science, 2011, Aug-13, Volume: 18

    Topics: Analysis of Variance; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Hypopigmentation; Luciferases; Melanins; Mice; Microscopy, Phase-Contrast; Monophenol Monooxygenase; Morpholines; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Sphingosine; TOR Serine-Threonine Kinases; Transfection

2011
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.
    Biochimica et biophysica acta, 2011, Volume: 1811, Issue:12

    Topics: Anthracenes; Cell Line, Tumor; Cell Movement; Cystamine; Cytoskeleton; Gene Expression Regulation, Neoplastic; Gene Silencing; GTP-Binding Proteins; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Keratin-8; MAP Kinase Signaling System; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Glutamine gamma Glutamyltransferase 2; Protein Kinase Inhibitors; RNA, Small Interfering; Serine; Sphingosine; Transglutaminases

2011
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.
    Cellular signalling, 2012, Volume: 24, Issue:1

    Topics: ADP Ribose Transferases; Amino Acid Substitution; Animals; Botulinum Toxins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesions; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Pseudopodia; Recombinant Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Stress Fibers

2012
Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.
    Experimental & molecular medicine, 2012, Feb-29, Volume: 44, Issue:2

    Topics: Amides; Blotting, Western; Cell Differentiation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Phosphorylcholine; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Sphingosine

2012
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:1

    Topics: Animals; Cells, Cultured; Coculture Techniques; Endothelial Cells; Humans; Integrin beta4; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; rho-Associated Kinases; RNA, Small Interfering; Sphingosine

2012
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
    Journal of cell science, 2012, May-01, Volume: 125, Issue:Pt 9

    Topics: Cell Line, Tumor; Cell Movement; Cytoskeleton; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Intermediate Filaments; Keratin-8; MAP Kinase Kinase Kinases; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Kinase Inhibitors; Serine; Signal Transduction; Sphingosine; Stomach Neoplasms

2012
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
    Molecular and cellular biochemistry, 2012, Volume: 367, Issue:1-2

    Topics: Animals; Cell Line; Dual Specificity Phosphatase 6; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypopigmentation; MAP Kinase Signaling System; Melanins; Mice; Phosphorylation; Phosphorylcholine; Protein Phosphatase 2; Protein Processing, Post-Translational; Sphingosine

2012
The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclin B; Female; Meiosis; Meiotic Prophase I; Metaphase; Microscopy, Fluorescence; Nuclear Envelope; Oocytes; Phosphorylcholine; Receptors, G-Protein-Coupled; RNA Interference; Signal Transduction; Sphingosine; Swine; Time Factors

2012
Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study.
    Biochimica et biophysica acta, 2013, Volume: 1828, Issue:4

    Topics: Cholesterol; Glycyrrhizic Acid; Membrane Microdomains; Microscopy, Fluorescence; Phosphatidylcholines; Phosphorylcholine; Sphingosine

2013
Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients.
    Molecular genetics and metabolism, 2014, Volume: 111, Issue:2

    Topics: Blood Cells; Case-Control Studies; Dried Blood Spot Testing; Humans; Lysosomes; Macrophages; Niemann-Pick Disease, Type B; Phosphorylcholine; Sphingomyelin Phosphodiesterase; Sphingosine

2014
Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway.
    Prostaglandins & other lipid mediators, 2014, Volume: 108

    Topics: Actins; Airway Remodeling; Cells, Cultured; Collagen; Fibroblasts; Gels; Humans; Lung; Phosphorylcholine; Receptors, Lysosphingolipid; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Transcriptional Activation; Transforming Growth Factor beta1

2014
Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells.
    Biochemical and biophysical research communications, 2014, Oct-24, Volume: 453, Issue:3

    Topics: Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Phosphorylcholine; Sphingosine

2014
Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Adolescent; Adult; Aged; Biomarkers; Blood Specimen Collection; Case-Control Studies; Edetic Acid; Female; Heparin; Humans; Male; Niemann-Pick Disease, Type C; Phosphorylcholine; Psychosine; Reproducibility of Results; Retrospective Studies; Sphingosine; Tandem Mass Spectrometry; Young Adult

2014
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:5

    Topics: Amides; Animals; Antihypertensive Agents; Basilar Artery; beta-Cyclodextrins; Carotid Artery, Internal; Cholesterol; Dietary Fats; Male; Membrane Microdomains; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Sphingosine; Vasospasm, Intracranial

2015
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species.
    Cardiovascular research, 2015, Apr-01, Volume: 106, Issue:1

    Topics: Animals; Calcium Channels; Cyclic N-Oxides; Dose-Response Relationship, Drug; Membrane Glycoproteins; Mesenteric Arteries; Mice; Mice, Knockout; Models, Animal; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphorylcholine; Protein Kinase C-epsilon; Pulmonary Artery; Reactive Oxygen Species; Signal Transduction; Sphingosine; Spin Labels; Type C Phospholipases; Vasoconstriction

2015
Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats.
    Journal of pediatric surgery, 2015, Volume: 50, Issue:4

    Topics: Acute Lung Injury; Animals; Contusions; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Oxidative Stress; Phosphorylcholine; Protective Agents; Rats; Rats, Wistar; Sphingosine; Treatment Outcome

2015
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.
    Biochimica et biophysica acta, 2015, Volume: 1851, Issue:9

    Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; beta-Cyclodextrins; Carrier Proteins; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Membrane Microdomains; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 8; Myocytes, Cardiac; Phosphoproteins; Phosphorylcholine; Primary Cell Culture; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases

2015
Sphingolipids inhibit vimentin-dependent cell migration.
    Journal of cell science, 2015, Jun-01, Volume: 128, Issue:11

    Topics: Animals; Cell Line; Cell Line, Tumor; Cell Movement; Fibroblasts; Humans; Lysophospholipids; Mice; Phosphorylation; Phosphorylcholine; Receptors, Lysosphingolipid; rho-Associated Kinases; Signal Transduction; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptors; Vimentin

2015
Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components.
    Chemistry and physics of lipids, 2015, Volume: 191

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Cholesterol; Glycerylphosphorylcholine; Lipid Bilayers; Microscopy, Fluorescence; Models, Molecular; Phosphatidylcholines; Phosphorylcholine; Sphingosine

2015
Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Biomarkers; Female; Humans; Inflammation; Lipids; Lysophospholipids; Male; Metabolic Syndrome; Middle Aged; Obesity; Phosphorylcholine; Risk Factors; Sphingosine; Tetraspanin 30

2015
Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Mar-01, Volume: 1014

    Topics: Antineoplastic Agents; Biological Products; Cell Survival; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; HCT116 Cells; Humans; Lactones; Lysophosphatidylcholines; Lysophospholipids; Metabolic Networks and Pathways; Metabolomics; Phosphatidylcholines; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry

2016
Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12.
    European journal of pharmacology, 2016, Mar-15, Volume: 775

    Topics: Cell Line; Cell Movement; Fingolimod Hydrochloride; Humans; Keratin-8; Organophosphates; Phosphorylation; Phosphorylcholine; Protein Phosphatase 2; Receptors, G-Protein-Coupled; RNA, Small Interfering; Sphingosine

2016
Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells.
    Biochimica et biophysica acta, 2016, Volume: 1863, Issue:6 Pt A

    Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Keratin-8; Lung Neoplasms; Membrane Glycoproteins; Microscopy, Confocal; Molecular Chaperones; Phosphorylation; Phosphorylcholine; Protein Binding; Protein Phosphatase 2; RNA Interference; Sphingosine; Ubiquitination

2016
Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways.
    Biochimica et biophysica acta, 2016, Volume: 1863, Issue:7 Pt A

    Topics: Animals; Antigens, Ly; beta Catenin; Biomarkers; Cell Differentiation; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; JNK Mitogen-Activated Protein Kinases; Membrane Microdomains; Membrane Proteins; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylcholine; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Stem Cells; Time Factors

2016
Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.
    Biochimica et biophysica acta, 2016, Volume: 1862, Issue:9

    Topics: Breast Neoplasms; Caproates; Cell Line, Tumor; Female; Flavonoids; Gene Silencing; Humans; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Phosphorylcholine; Polycyclic Compounds; Sphingosine; Valine; Wnt Signaling Pathway

2016
Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats.
    Renal failure, 2016, Volume: 38, Issue:7

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Contrast Media; Creatinine; Humans; Injections, Intraperitoneal; Kidney; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phosphorylcholine; Rats; Rats, Wistar; Sphingosine; Superoxide Dismutase

2016
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells.
    Biochemical pharmacology, 2016, 09-01, Volume: 115

    Topics: Animals; Cell Adhesion; Cells, Cultured; Coculture Techniques; Macrophages; Male; Membrane Microdomains; Muscle, Smooth, Vascular; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine; Tumor Necrosis Factor-alpha

2016
Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival.
    Molecular medicine reports, 2016, Volume: 14, Issue:4

    Topics: Adipose Tissue; Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cryopreservation; Endothelial Progenitor Cells; Graft Survival; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylcholine; Sphingosine

2016
Omega-3 and omega-6 DPA equally inhibit the sphingosylphosphorylcholine-induced Ca
    Scientific reports, 2017, 02-07, Volume: 7

    Topics: Calcium; Cell Membrane; Cells, Cultured; Coronary Vessels; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylation; Phosphorylcholine; Protein Transport; rho-Associated Kinases; Sphingosine

2017
Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
    Oncotarget, 2017, Mar-28, Volume: 8, Issue:13

    Topics: Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Keratins; Lung Neoplasms; Neoplasm Staging; Phosphorylation; Phosphorylcholine; Prognosis; Proto-Oncogene Proteins c-akt; ras Proteins; Sphingosine; Survival Rate; Tumor Cells, Cultured

2017
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
    Analytical biochemistry, 2017, May-15, Volume: 525

    Topics: Biomarkers; Case-Control Studies; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Niemann-Pick Disease, Type A; Niemann-Pick Disease, Type B; Niemann-Pick Disease, Type C; Phosphorylcholine; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Tandem Mass Spectrometry

2017
DJ-1 Regulates Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle-like Cells in Response to Sphingosylphosphorylcholine.
    Proteomics, 2017, Volume: 17, Issue:21

    Topics: Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Oxidation-Reduction; Phosphorylcholine; Protein Deglycase DJ-1; Proteome; Reactive Oxygen Species; Sphingosine

2017
Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:1

    Topics: Animals; Antiprotozoal Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membrane; Homeostasis; Leishmania donovani; Membrane Potential, Mitochondrial; Nifedipine; Organelles; Phosphorylcholine; Sphingosine

2018
A Novel Regulatory Mechanism for Differentiation of Mesenchymal Stem Cell: Redox State of DJ-1 Matters.
    Proteomics, 2018, Volume: 18, Issue:1

    Topics: Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Muscle, Smooth; Myocytes, Smooth Muscle; Oxidation-Reduction; Phosphorylcholine; Reactive Oxygen Species; Sphingosine

2018
Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome.
    Blood, 2018, 08-02, Volume: 132, Issue:5

    Topics: Animals; Blood Platelets; Humans; Lipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylcholine; Platelet Activation; Sphingomyelin Phosphodiesterase; Sphingosine; Thrombosis

2018
Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry.
    Journal of the American Chemical Society, 2018, 07-11, Volume: 140, Issue:27

    Topics: Aldehydes; Amines; Biomimetic Materials; Biomimetics; Imines; Liposomes; Phospholipids; Phosphorylcholine; Sphingosine

2018
Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling.
    Journal of cellular physiology, 2019, Volume: 234, Issue:7

    Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine

2019
Complete Myogenic Differentiation of Adipogenic Stem Cells Requires Both Biochemical and Mechanical Stimulation.
    Annals of biomedical engineering, 2020, Volume: 48, Issue:3

    Topics: Adipogenesis; Adult; Aged; Bioreactors; Bone Morphogenetic Protein 4; Cell Differentiation; Collagen Type I; Female; Fibrin; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Myocytes, Smooth Muscle; Phosphorylcholine; Physical Stimulation; Pressure; Sphingosine; Stress, Mechanical; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta; Tunica Media

2020
Alterations in phospholipid profiles of erythrocytes deep-frozen without cryoprotectants.
    Drug testing and analysis, 2019, Volume: 11, Issue:8

    Topics: Blood Preservation; Cryopreservation; Erythrocyte Membrane; Erythrocytes; Humans; Phospholipids; Phosphorylcholine; Sphingosine

2019
Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549 cells in a synergistic manner.
    Chemico-biological interactions, 2019, Sep-01, Volume: 310

    Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Synergism; Humans; Lysophospholipids; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Sphingosine

2019
Development of a Diagnostic Screening Strategy for Niemann-Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine.
    Biological & pharmaceutical bulletin, 2020, Sep-01, Volume: 43, Issue:9

    Topics: Chromatography, Liquid; Humans; Niemann-Pick Diseases; Phosphatidylcholines; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry

2020
A combination of 7-ketocholesterol, lysosphingomyelin and bile acid-408 to diagnose Niemann-Pick disease type C using LC-MS/MS.
    PloS one, 2020, Volume: 15, Issue:9

    Topics: Bile Acids and Salts; Biomarkers; Chromatography, Liquid; Humans; Infant, Newborn; Ketocholesterols; Niemann-Pick Disease, Type C; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry

2020
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway.
    Apoptosis : an international journal on programmed cell death, 2020, Volume: 25, Issue:11-12

    Topics: Animals; Apoptosis; Calmodulin; Cell Hypoxia; Fibrosis; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Rats, Wistar; Sphingosine; STAT3 Transcription Factor

2020
Identification of a Reliable Biomarker Profile for the Diagnosis of Gaucher Disease Type 1 Patients Using a Mass Spectrometry-Based Metabolomic Approach.
    International journal of molecular sciences, 2020, Oct-23, Volume: 21, Issue:21

    Topics: Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Early Diagnosis; Female; Gaucher Disease; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Phosphorylcholine; Prognosis; Psychosine; Sensitivity and Specificity; Sphingosine; Young Adult

2020
MicroRNA-155-5p/EPAS1/interleukin 6 pathway participated in the protection function of sphingosylphosphorylcholine to ischemic cardiomyocytes.
    Life sciences, 2021, Jan-01, Volume: 264

    Topics: Animals; Apoptosis; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Cardiotonic Agents; Cell Hypoxia; Cell Nucleus; Down-Regulation; Fibroblast Growth Factor 2; HEK293 Cells; Humans; Interleukin-6; MicroRNAs; Models, Biological; Myocardial Ischemia; Myocytes, Cardiac; Phosphorylation; Phosphorylcholine; Rats, Wistar; RNA, Messenger; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Transcription, Genetic; Vascular Endothelial Growth Factor A

2021
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:1

    Topics: Animals; Blotting, Western; Bone Resorption; Calcium; Calmodulin; Cell Survival; Female; Mice; Mice, Inbred C57BL; Osteoclasts; Osteoporosis; Ovariectomy; Phosphorylcholine; Real-Time Polymerase Chain Reaction; Sphingosine; X-Ray Microtomography

2021
A Novel Function of Sphingosylphosphorylcholine on the Inhibitory Effects of Acetylcholinesterase Activity.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:11

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Neostigmine; Phosphorylcholine; Rivastigmine; Sphingosine

2021
Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway.
    Journal of cardiovascular pharmacology, 2022, 01-05, Volume: 79, Issue:4

    Topics: Animals; Calcium; Hesperidin; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Swine

2022
Sphingosylphosphorylcholine ameliorates experimental sjögren's syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells.
    Immunology letters, 2022, Volume: 248

    Topics: Animals; B-Lymphocytes, Regulatory; Disease Models, Animal; Female; Humans; Inflammation; Mice; Mice, Inbred NOD; Phosphorylcholine; Sialadenitis; Sjogren's Syndrome; Sphingosine

2022
Sphingosylphosphorylcholine ameliorates doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by reducing excessive mitophagy and mitochondrial dysfunction.
    Toxicology and applied pharmacology, 2022, 10-01, Volume: 452

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cardiotoxicity; Doxorubicin; Mitochondria; Mitophagy; Myocytes, Cardiac; Phosphorylcholine; Sphingosine; Ubiquitin-Protein Ligases; Zebrafish

2022
Landscape of circulating metabolic fingerprinting for keloid.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Humans; Keloid; Logistic Models; Palmitoylcarnitine; Phosphorylcholine; Sphingosine

2022