phosphorylcholine has been researched along with sphingosine in 278 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (2.52) | 18.7374 |
1990's | 73 (26.26) | 18.2507 |
2000's | 127 (45.68) | 29.6817 |
2010's | 59 (21.22) | 24.3611 |
2020's | 12 (4.32) | 2.80 |
Authors | Studies |
---|---|
Broekhuyse, RM; Roelfzema, H; Veerkamp, JH | 1 |
Bocian, KM; Pagano, RE; Ting, AE; Winiski, AP; Wolf, DE | 1 |
Conti, F; Delfini, M; Miccheli, A; Piccolella, E; Ricciolini, R | 1 |
Desai, NN; Spiegel, S | 1 |
Dressler, KA; Kan, CC; Kolesnick, RN | 1 |
Bian, J; Ghosh, TK; Gill, DL | 1 |
Hara, A; Sugiyama, E; Taketomi, T; Uemura, K | 2 |
Insel, PA; Meier, KE; Slivka, SR | 1 |
Callahan, JW; Strasberg, PM | 1 |
Hamilton, JA; Maulik, PR; Shipley, GG; Sripada, PK | 1 |
Callahan, JW; Gerrie, J; Jones, CS; Shankaran, P | 1 |
Hara, A; Taketomi, T | 1 |
Bitar, KN; Yamada, H | 1 |
Rozengurt, E; Seufferlein, T | 2 |
Kondo, Y; Okajima, F | 1 |
Berger, A; Rosenthal, D; Spiegel, S | 1 |
Farach-Carson, MC; Karin, NJ; Liu, R | 1 |
Betto, R; Dettbarn, C; Palade, P; Sabbadini, R; Salviati, G | 1 |
Alessenko, AV; Romanenko, EB; Vanyushin, BF | 1 |
Casey, G; Mills, GB; Xu, Y | 1 |
Breu, J; Eldar, H; Livneh, E; Slack, BE; Wurtman, RJ | 1 |
Costa, DJ; Fitz, JG; Huang, LW; Kim, S; Kindman, LA; Lakhani, V; Peters, KG; Sharara, AI | 1 |
Hannun, YA | 1 |
Ekokoski, E; Törnquist, K | 1 |
Kwan-Yeung, L; Wong, K | 1 |
Brooker, G; Buckley, NE; Carlson, RO; Desai, NN; Mattie, ME; Olivera, A; Seki, T; Spiegel, S | 1 |
Dulaney, JT; Fujii, H; Inagaki, F; Ohta, S; Sugita, M; Suzuki, A; Suzuki, M | 1 |
Milstien, S; Spiegel, S | 1 |
Ohno, K | 1 |
Henry, FA; Nielsen, TB; Spiegel, S; Sun, L; Xu, L | 1 |
Demopoulos, CA; Lianos, EA; Zanglis, A | 1 |
Jakobs, KH; Laser, KT; Meyer Zu Heringdorf, D; Van Koppen, CJ; Zhang, C | 1 |
Higaki, Y; Higuchi, K; Imokawa, G; Kawainami, S; Kawashima, M; Murata, Y; Ogata, J; Tsuchiya, T; Yada, Y | 1 |
Field, FJ; Hunninghake, GW; Mallampalli, RK; Mathur, SN; Salome, RG; Warnock, LJ | 1 |
Chueh, SH; Huang, WC | 1 |
Palade, P; Yasui, K | 1 |
Berger, A; Bittman, R; Schmidt, RR; Spiegel, S | 1 |
Jarvis, WD; Spangelo, BL | 1 |
Brandts, BK; Bünemann, M; Desiderio, DM; Liliom, K; Miller, D; Pott, L; Sun, G; Tigyi, G; Tseng, JL | 1 |
Himmel, HM; Jakobs, KH; Meyer zu Heringdrof, D; van Koppen, CJ; Windorfer, B | 1 |
Furuya, S; Hirabayashi, Y; Kurono, S | 1 |
Anderson, WH; Chung, T; Crilly, KS; Kiss, Z; Mukherjee, JJ | 1 |
Betto, R; Dettbarn, C; Glembotski, CC; Kindman, LA; Krown, K; Palade, PT; Pereon, Y; Sabbadini, RA; Salviati, G; Teresi, A; Turcato, F; Yasui, K | 1 |
Kondo, Y; Ohwada, S; Okajima, F; Yamada, T | 1 |
Bielawska, A; Greenberg, CS; Hannun, YA; Lai, TS; Peoples, KA | 1 |
Kiss, Z; Mukherjee, JJ | 1 |
Hrelia, S; Orlati, S; Rugolo, M | 1 |
Kaida, T; Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T | 1 |
Ito, M; Izu, H; Sueyoshi, N | 1 |
Grinstein, S; Törnquist, K; Woodside, M | 1 |
Banasiak, M; Barańska, J; Czarny, M; Stepkowski, D; Wiktorek-Wójcik, M | 1 |
Rodríguez-Fernández, JL; Rozengurt, E | 2 |
Furukawa, F; Matsushita, K; Nishimura, K; Takigawa, M; Tokura, Y; Wakita, H | 1 |
Berger, A; Cultaro, CM; Segal, S; Spiegel, S | 1 |
Crilly, KS; Kiss, Z; Tomono, M | 1 |
Himmel, HM; Jakobs, KH; Meyer zu Heringdorf, D; Ravens, U; van Koppen, CJ; Windorfer, B | 1 |
Fröde, R; Jakobs, KH; Lass, H; Meyer zu Heringdorf, D; Neumann, E; Niederdräing, N; Van Koppen, CJ | 1 |
Hrelia, S; Lorenzini, A; Orlati, S; Porcelli, AM; Rugolo, M | 1 |
Chin, TY; Chueh, SH | 2 |
Bläckberg, L; Duan, RD; Farooqi, A; Hernell, O; Nilsson, A; Nyberg, L | 1 |
Grosman, N | 1 |
Chen, PF; Chin, TY; Chueh, SH | 1 |
Higuchi, K; Imokawa, G; Kondo, H; Takagi, Y; Yada, Y | 1 |
Hrelia, S; Orlati, S; Porcelli, AM; Rugolo, M | 1 |
Rodriguez-Lafrasse, C; Vanier, MT | 1 |
Angelova, MI; Hristova, N; Tsoneva, I | 1 |
Calcerrada, MC; Catalan, RE; Martinez, AM; Miguel, BG | 2 |
Björklund, S; Ekokoski, E; Nikmo, A; Törnquist, K; Vainio, M | 1 |
Gonda, K; Okamoto, H; Shigematsu, H; Takuwa, N; Takuwa, Y; Yatomi, Y | 1 |
Barańska, J; Bobeszko, M; Dygas, A; Sidorko, M | 1 |
Barańska, J; Wójcik, M | 1 |
Kobayashi, S; Matsuda, M; Matsuzaki, M; Miwa, S; Mizukami, Y; Mogami, K; Ohmura, M; Todoroki-Ikeda, N; Yoshida, K | 1 |
Hodgson, DM; Rosenberg, A; Taylor, AN; Zhang, Z | 1 |
Furukawa, F; Nishimura, K; Seo, N; Takigawa, M; Tokura, Y; Wakita, H | 1 |
Berlin, JR; Imanaga, I; Uehara, A; Yasukochi, M | 1 |
Kurabayashi, M; Nagai, R; Okajima, F; Sekiguchi, K; Yokoyama, T | 1 |
Hanske, J; Jakobs, KH; Lümmen, G; Meyer zu Heringdorf, D; Rümenapp, U; Virchow, S | 1 |
Baudhuin, LM; Damron, DS; Hong, G; Wu, W; Xiao, Y; Xu, Y; Zhu, K | 1 |
Kanazawa, T; Kawasaki, T; Kozutsumi, Y; Momoi, M; Nakamura, S; Sabe, H; Takematsu, H; Yamaji, T; Yamamoto, A; Yano, H | 1 |
Bender, K; Brandts, B; Bünemann, M; Desiderio, DM; Liliom, K; Miller, D; Nusser, N; Pott, L; Sun, G; Tigyi, G | 1 |
Boguslawski, G; English, D; Harvey, KA; Kovala, AT; Lyons, D | 1 |
Kon, J; Murata, N; Okajima, F; Sato, K; Tomura, H | 1 |
Bischoff, A; Czyborra, P; Fetscher, C; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC | 1 |
Bischoff, A; Czyborra, P; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC | 1 |
Hokazono, Y; Kobayashi, S; Kusuda, T; Miyake, T; Mizukami, Y; Mogami, K; Sato, M; Suzuki, S; Todoroki-Ikeda, N; Yamagata, H; Yamamoto, K | 1 |
Assmann, G; Fobker, M; Höbbel, G; Junker, R; Nofer, JR; Seedorf, U; Tepel, M; von Eckardstein, A; Voss, R; Walter, M; Wolinska, I; Zidek, W | 1 |
Bittman, R; Verbicky, CA | 1 |
Hitomi, K; Ikura, K; Maki, M; Yamagiwa, Y; Yamanishi, K | 1 |
Allessie, MA; Brandts, B; Trappe, HJ; Tüttelmann, F; Van Bracht, M | 1 |
Alemany, R; Jakobs, KH; Kuchar, I; Lass, H; Lipinski, M; Meyer zu Heringdorf, D; Rümenapp, U | 1 |
Baker, DL; Bender, K; Brandts, B; Bünemann, M; Desiderio, DM; Eickel, A; Fabian, MJ; Liliom, K; Malik, KU; Miller, DD; Nusser, N; Pott, L; Sun, G; Tigyi, G; Virág, T; Wang, DA | 1 |
Eu, JP; Greenberg, CS; Hausladen, A; Lai, TS; Slaughter, TF; Stamler, JS | 1 |
Lynch, KR; Macdonald, TL | 1 |
Baudhuin, LM; Hong, G; Mok, SC; Morrison, BH; Schwartz, BM; Wu, W; Xiao, YJ; Xu, Y | 1 |
Assmann, G; Fobker, M; Junker, R; Levkau, B; Nofer, JR; Seedorf, U; von Eckardstein, A; Wolinska, I | 1 |
Carson, MJ; Lo, D | 1 |
Kabarowski, JH; Le, LQ; Witte, ON; Xu, Y; Zhu, K | 1 |
Baudhuin, LM; Cristina, KL; Hong, G; Kabarowski, JH; Williams, FS; Witte, ON; Xu, Y; Zhu, K | 1 |
Higuchi, K; Ichikawa, Y; Imokawa, G; Kawashima, M; Kondo, H; Takagi, Y; Yada, Y | 1 |
Karin, NJ; Lyons, JM | 1 |
de Pietri Tonelli, D; Grohovaz, F; Schnurbus, R; Zacchetti, D | 1 |
Han, SS; Lee, M | 1 |
Baldini, G; Borgatti, P; Bortul, R; Capitani, S; Martelli, AM; Neri, LM; Tabellini, G | 1 |
Xu, Y | 1 |
Himmel, HM; Jakobs, KH; Meyer zu Heringdorf, D | 1 |
Somlyo, AV | 1 |
Haze, K; Kashiwagi, S; Kobayashi, S; Kuriyama, S; Kurokawa, T; Miwa, S; Mizukami, Y; Mogami, K; Nakao, F; Sato, M; Shirao, S; Suzuki, M; Todoroki-Ikeda, N | 1 |
Kim, J; Lee, T; Sohn, U | 1 |
Ito, M; Kobayashi, S; Matsuzaki, M; Miwa, S; Mizukami, Y; Mogami, K; Nakao, F; Shirao, S; Todoroki-Ikeda, N | 1 |
Arikawa, J; Imokawa, G; Ishibashi, M; Kawashima, M; Okamoto, R; Takagi, Y | 1 |
Altmann, C; Czyborra, P; Hein, P; Michel, MC; Steenpass, V | 1 |
Lee, JH; Ogawa, H; Park, JK; Piao, YJ; Seo, EY; Suhr, KB; Tsuboi, R | 1 |
Altmann, C; Böyükbas, D; Haude, M; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC | 1 |
Hermans-Borgmeyer, I; Ignatov, A; Joost, P; Kreienkamp, HJ; Lintzel, J; Methner, A; Schaller, HC; Thomsen, S | 1 |
Berlin, JR; Kobayashi, S; Uehara, A; Yasukochi, M | 1 |
Brailoiu, E; Dun, NJ; Patel, S | 1 |
Brailoiu, E; Dun, NJ | 1 |
Arikawa, K; Kitayama, J; Nagawa, H; Sugimoto, N; Takehara, K; Takuwa, N; Takuwa, Y; Yamaguchi, H | 1 |
Adler, G; Beil, M; Eggermann, J; Gern, U; Micoulet, A; Omary, MB; Paschke, S; Seufferlein, T; Spatz, J; Van Veldhoven, PP; von Wichert, G; Waltenberger, J; Walther, P; Wolff-Hieber, E | 1 |
DAWSON, RM | 1 |
Aoki, J; Bandle, RW; Clair, T; Koh, E; Liotta, LA; Mills, GB; Nam, SW; Ptaszynska, MM; Schiffmann, E; Stracke, ML | 1 |
Higuchi, K; Ichikawa, Y; Imokawa, G; Kawashima, M | 1 |
Ikari, S; Matsuda, H; Ochi, S; Oda, M; Sakurai, J | 1 |
Deguchi, H; Griffin, JH; Yegneswaran, S | 1 |
Gotoh, E; Hanada, K; Miura, Y; Nara, F; Nishijima, M | 1 |
Michalak, K; Teisseyre, A | 1 |
Bittman, R; Li, Z; Mintzer, E | 1 |
Chae, EK; Kim, CD; Kye, KC; Lee, JH; Park, JK; Park, S; Piao, YJ; Suhr, KB | 1 |
Aksu, B; Altinok, G; Bingol-Kologlu, M; Dindar, H; Fitoz, S; Gokcora, IH; Renda, N; Yagmurlu, A | 1 |
Kostenis, E | 1 |
Murakami, N; Okuno, T; Shimizu, T; Yokomizo, T | 1 |
Fetscher, C; Hedemann, J; Michel, MC | 1 |
Im, DS; Jeon, ES; Kang, YJ; Kim, HS; Kim, JH; Kim, YK; Ryu, SH; Song, HY | 1 |
Bassa, BV; Ganji, SH; Kamanna, VS; Roh, DD | 1 |
Aoki, J; Arai, H; Kakehi, Y; Natori, Y; Nishikawa, K; Sakagami, H | 1 |
Kim, CD; Kim, JM; Kye, KC; Lee, CH; Lee, JH; Park, JK; Piao, YJ; Seo, YJ; Suhr, KB; Zhu, MJ | 1 |
Anand-Apte, B; Cristina, K; Ebrahem, Q; Jiang, Y; Kim, KS; Lum, H; Qiao, J; Ren, J; Taylor, KL; Tipps, R; Xiao, YJ; Xu, Y | 1 |
Jeon, ES; Jung, JS; Kang, YJ; Kim, JH; Kim, YK; Song, HY; Woo, JS | 1 |
Bittman, R; Lu, X | 1 |
Chen, YY; Kim, CD; Kwon, YB; Kye, KC; Lee, JH; Lee, S; Lee, WH; Lim, JS; Park, JK; Seo, YJ; Suhr, KB; Zhu, MJ | 1 |
Aaronson, PI; Leach, RM; Patel, R; Snetkov, VA; Thomas, GD; Ward, JP | 1 |
Damaj, BB; Jin, Y; Maghazachi, AA | 1 |
Schubert, R | 1 |
Harzer, K; Keulemans, JL; Ledvinova, J; Mengel, E; Santer, R; Schoonderwoerd, K; van Diggelen, OP; Voznyi, YV; Zschiesche, M | 1 |
Damirin, A; Hashimoto, K; Komachi, M; Kon, J; Mogi, C; Okajima, F; Sato, K; Tobo, M; Tomura, H; Wang, JQ | 1 |
Im, DS | 1 |
Bae, YC; Jeon, ES; Jung, JS; Kim, JH; Kim, MR; Moon, HJ; Song, HY | 1 |
Alewijnse, AE; Michel, MC | 1 |
Mathieson, FA; Nixon, GF | 1 |
Fujiwaki, T; Kobayashi, H; Murakami, Y; Shimada, T; Takahashi, N; Tasaka, M; Yamaguchi, S | 1 |
Afrasiabi, E; Blom, T; Ekokoski, E; Törnquist, K; Tuominen, RK | 1 |
Bischoff, A; Czyborra, C; Michel, MC | 1 |
Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Ryu, SK | 1 |
Huh, CH; Kim, DS; Kwon, SB; Park, ES; Park, KC; Park, SH; Youn, SW | 1 |
Hemmings, DG | 1 |
Beil, M; Dao, M; Lim, CT; Micoulet, A; Mills, JP; Seufferlein, T; Spatz, J; Suresh, S | 1 |
Esato, K; Guo, F; Hamano, K; Kishi, H; Kobayashi, S; Morikage, N; Sato, M; Shirao, S; Soma, M; Yano, T | 1 |
Dammer, E; Sewer, MB; Urs, AN | 1 |
Brown, DL; Kohama, K; Kumagai, H; Li, S; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Yoshiyama, S | 1 |
Adler, G; Beil, M; Busch, T; Kleger, A; Liebau, S; Paschke, S; Prelle, K; Rolletschek, A; Seufferlein, T; Wobus, A; Wolf, E | 1 |
Bae, YS; Lee, HY; Shin, EH | 1 |
Katayama, T; Kohama, K; Nakamura, A; Tanaka, H; Wang, HH; Yoshiyama, S | 1 |
Bae, YC; Jeon, ES; Jung, JS; Kim, JH; Kim, YM; Lee, MJ; Moon, HJ; Song, HY | 1 |
Brahmbhatt, VV; Ford, DA; Frank, EC; Hsu, FF; Kao, JL | 1 |
Jeon, ES; Kim, JH; Lee, MJ; Sung, SM | 1 |
Back, SJ; Kim, CD; Kwon, YB; Lee, JH; Lee, YS; Park, JK; Piao, YJ; Seo, YJ; Sohn, KC; Suhr, KB | 1 |
Ceballos, A; Geffner, J; Maggini, J; Martínez, D; Nahmod, K; Sabatté, J; Salamone, G; Salomón, H; Vermeulen, M | 1 |
Alewijnse, AE; Jongsma, M; Michel, MC; Mulders, AC; Peters, SL | 1 |
Kajiya, K; Kawamichi, H; Kishi, H; Kobayashi, S | 1 |
Damirin, A; Kimura, T; Komachi, M; Kurose, H; Liu, JP; Mogi, C; Murata, N; Okajima, F; Sato, K; Tobo, M; Tomura, H; Wang, JQ | 1 |
Jeon, ES; Kim, JH; Kim, YM; Lee, MJ; Moon, HJ; Oh, CK | 1 |
Eberhardt, W; Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C | 1 |
Afrasiabi, E; Balthasar, S; Blom, T; Törnquist, K | 1 |
Hama, K; Hatano, Y; Kimoto, Y; Kinoshita, H; Matsuda, N; Nakahata, K; Tohyama, S | 1 |
Chiulli, N; Codazzi, F; Di Cesare, A; Gravaghi, C; Grohovaz, F; Zacchetti, D | 1 |
Fonfria, E; Michel, AD | 1 |
Hashiba, Y; Imai, H; Saito, N; Sasaki, T; Shimizu, T; Tosaka, M | 1 |
Arioka, M; Cheon, SH; Ikeno, Y; Kitamoto, K; Konno, N; Nakamura, A | 1 |
Kajiya, K; Kawamichi, H; Kishi, H; Kobayashi, S; Takada, Y; Xu, D | 2 |
Kovacs, E; Liliom, K | 1 |
Ha, NC; Han, M; Im, DS; Jo, JY; Kim, HL; Kim, K; Kim, YL; Sacket, SJ | 1 |
Hunter, I; Mathieson, FA; Nixon, GF | 1 |
Li, Y; Michel, MC; Mulders, AC; Nau, S | 1 |
Aaronson, PI; Knock, GA; Leach, RM; Shaifta, Y; Snetkov, VA; Teague, B; Thomas, GD; Ward, JP | 1 |
Abdelrahman, M; Benetti, E; Collino, M; Cuzzocrea, S; Fantozzi, R; Gallicchio, M; Mazzon, E; Murch, O; Thiemermann, C | 1 |
Im, BO; Kim, YS; Ko, SK; Min, YS; Park, SY; Sohn, UD; Song, HJ; Whang, WK | 1 |
Han, ES; Kim, H; Kim, HJ; Kim, JJ; Kim, KM; Koh, JY; Lee, CH; Noh, MS; Park, SM | 1 |
Ishikawa, R; Katayama, T; Kohama, K; Nakamura, A; Okagaki, T; Qin, X; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Ye, LH; Zhao, T | 1 |
Fujiwaki, T; Tasaka, M; Yamaguchi, S | 1 |
Fujisawa, H; Kobayashi, S; Kudo, A; Kunitsugu, I; Kurokawa, T; Ogasawara, K; Ogawa, A; Shirao, S; Soma, M; Suzuki, M; Yoneda, H | 1 |
Hashimoto, M; Iwamaru, Y; Kitani, H; Sato, M; Sugama, S; Takenouchi, T | 1 |
Han, J; Jeon, ES; Kim, JH; Kim, YM; Lee, MJ; Park, WS | 1 |
Agudo-López, A; Catalán, E; Fernández, I; Martínez, AM; Miguel, BG; Toboso, I | 1 |
Ahn, DS; Choi, SK; Lee, YH | 1 |
Gao, Y; Ishikawa, R; Kohama, K; Matsumoto, A; Nakamura, A; Qin, X; Wang, HH; Xie, C; Ye, LH; Yoshiyama, S; Zhang, Y | 1 |
Aksu, B; Aktas, C; Civelek, S; Guzel, A; Inan, M; Kanter, M; Umit, H; Uzun, H | 1 |
Imokawa, G | 1 |
Huwiler, A; Pfeilschifter, J | 1 |
Akimura, T; Fujisawa, H; Kashiwagi, S; Kato, S; Kishi, H; Kobayashi, S; Kurokawa, T; Miwa, S; Mogami, K; Ogasawara, K; Ogawa, A; Sato, M; Shirao, S; Soma, M; Suzuki, M; Yumiya, Y | 1 |
Asano, S; Hatano, R; Inoue, T; Ito, M; Itonori, S; Shinohara, R; Sugita, M; Yokoi, K | 1 |
Andoh, T; Kuraishi, Y; Saito, A | 1 |
Adams, EJ; Besra, GS; Chen, X; Cook, ME; Cox, DG; Fox, LM; Gumperz, JE; Hildebrand, WH; Howell, AR; Lockridge, JL; Ndonye, RM; Scharf, L; Trott, DL; Veerapen, N; Wang, X | 1 |
Kim, HJ; Kim, KM; Kim, SY; Koh, JY; Lee, CH; Lee, HJ; Noh, MS; Park, MK | 1 |
Kovacs, E; Liliom, K; Tóth, J; Vértessy, BG | 1 |
Abdollahi, H; DiMuzio, PJ; Harris, LJ; McIlhenny, S; Tulenko, TN; Zhang, P | 1 |
Sundh, M; Sutherland, DS; Svedhem, S | 1 |
Choi, H; Kim, HJ; Kim, KM; Kim, S; Lee, CH; Noh, M; Shin, JH | 1 |
Kim, DS; Kwon, NS; Kwon, SB; Park, KC; Park, SH | 1 |
Hunter, I; Mathieson, FA; Nixon, GF; Wirrig, C | 1 |
Hatake, K; Kudo, R | 1 |
Furuichi, M; Horii, K; Imai, Y; Masuda, H; Oka, A; Omi, K; Sakai, N; Tanimoto, T; Waga, I; Yoshida, Y | 1 |
Kovacs, E; Liliom, K; Meissner, G; Pasek, DA; Xu, L | 1 |
Kanazawa, T; Kozutsumi, Y; Naito, Y; Okano, M; Takematsu, H; Yamamoto, H | 1 |
Chun, J; Echtermeyer, F; Herrgott, I; Herzog, C; Hildebrand, R; Johanning, K; Larmann, J; Levkau, B; Mersmann, J; Müller, FU; Schmitz, M; Theilmeier, G; Winterhalter, M | 1 |
Ge, D; Jing, Q; Meng, N; Miao, J; Su, L; Zhang, S; Zhang, Y; Zhao, J | 1 |
Bae, YS; Baek, SH; Chung, J; Jung, YS; Kim, HJ; Kim, SD; Kwon, JY; Lee, HY; Lee, SY; Shim, JW | 1 |
Cho, H; Kong, JY; Lee, GH; Lee, J; Lee, SJ; Lim, HJ; Myung, CS; Park, WK; Yi, H | 1 |
Andoh, T; Haza, S; Kuraishi, Y; Saito, A | 1 |
Baek, KJ; Jeong, HS; Kim, DS; Kwon, NS; Lee, SH; Park, KC; Yun, HY | 1 |
Kim, SY; Lee, CH; Lee, HJ; Noh, M; Park, MK; Shin, J | 1 |
Kim, JH; Kim, KH; Kim, MB; Kim, YM; Ko, HC; Lee, MJ | 1 |
Ge, D; Meng, N; Miao, JY; Su, L; Zhang, SL; Zhang, Y; Zhao, J | 1 |
Armacki, M; Busch, T; Eiseler, T; Jansen, J; Joodi, G; Omary, MB; Seufferlein, T; Spatz, J; Temme, C; von Wichert, G | 1 |
Jeong, HS; Kim, DS; Park, KC | 1 |
Chen, L; Hou, Y; Liu, ZH; Luo, YB; Ma, JY; Qi, ST; Schatten, H; Sun, QY; Wang, YP; Wei, Y; Yang, CR; Zhang, QH | 1 |
Nakagawara, J; Ogasawara, K; Shirao, S; Suzuki, M; Tominaga, T; Yoneda, H | 1 |
Nakahara, H; Sakamoto, S; Shibata, O; Shoyama, Y; Uto, T | 1 |
Chuang, WL; Cooper, S; Cox, GF; Keutzer, J; McGovern, MM; Pacheco, J; Zhang, XK | 1 |
Fang, QH; Kamio, K; Kawasaki, S; Kim, HJ; Kobayashi, T; Liu, X; Mao, LJ; Rennard, SI; Sugiura, H; Togo, S; Wang, XQ | 1 |
Gao, J; Li, W; Liu, P; Miao, J; Yue, H; Zhao, J | 1 |
Amraoui, Y; Garzotti, M; Groenen, P; Kolb, SA; Marquardt, T; Marques Lourenço, C; Mengel, E; Morand, O; Reunert, J; Welford, RW | 1 |
Fujii, M; Ishihara, H; Kagawa, Y; Koizumi, H; Nomura, S; Oka, F; Owada, Y; Sadahiro, H; Shinoyama, M; Shirao, S; Sugimoto, K; Suzuki, M; Tamechika, M; Yoneda, H | 1 |
Aaronson, PI; Knock, GA; Prieto-Lloret, J; Shaifta, Y; Smirnov, SV; Snetkov, VA; Ward, JP | 1 |
Aksu, B; Aksu, F; Ayaz, A; Ayvaz, S; Cemek, M; Demirtaş, S; Karaca, T | 1 |
Chang, F; Li, WJ; Liu, J; Liu, PP; Miao, JY; Yue, HW; Zhao, J | 1 |
Eriksson, JE; Fazeli, E; Goto, H; Hyder, CL; Imanishi, SY; Inagaki, M; Isoniemi, KO; Kemppainen, K; Törnquist, K | 1 |
Ogino, T; Yokota, K | 1 |
El-Najjar, N; Liebisch, G; Orsó, E; Schmitz, G; Wallner, S | 1 |
Gao, D; Guan, J; Guo, Y; Jiang, Y; Liu, H; Wang, Y; Xie, W; Yang, T | 1 |
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Kim, SH; Kim, SY; Lee, CH; Lee, H; Park, MK; Park, S | 1 |
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Lee, EJ; Park, MK | 1 |
Li, W; Liu, H; Liu, P; Yin, D; Zhang, S; Zhao, J | 1 |
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Lee, H; Nam, S; Park, MK | 1 |
Aksu, B; Aksu, F; Ayvaz, S; Bulur, S; Erman, H; Karaca, T; Keles, N; Unlu, E; Unlu, N; Uzun, H | 1 |
Bauer, P; Burlina, A; Coll, MJ; Gissen, P; Goizet, C; Hendriksz, CJ; Kolb, SA; Latour, P; Marquardt, T; Vanier, MT; Welford, RW | 1 |
McKean, JS; Nixon, GF; Wilson, HM; Wirrig, C | 1 |
Bae, YC; Choi, CW; Lee, JW; Nam, KW; Song, JS | 1 |
Kishi, H; Kobayashi, S; Lyu, B; Zhang, M; Zhang, Y | 1 |
Byun, HJ; Kang, GJ; Kim, EJ; Kim, HJ; Lee, CH; Park, MK | 1 |
Asfaw, B; Gulinello, ME; Jahnova, H; Kuchar, L; Ledvinova, J; Lugowska, A; Malinova, V; Poupetova, H; Sikora, J | 1 |
Baek, S; Cui, L; Jung, SH; Kim, B; Ko, K; Lee, KP; Won, KJ | 1 |
Benaim, G; Hernandez-Rodriguez, V; Pinto-Martinez, AK; Rodriguez-Durán, J; Serrano-Martin, X | 1 |
Yamawaki, H | 1 |
Diaz, GA; Ji, AJ; Jouvin, MH; Lachmann, RH; Nandy, I; Puga, AC; Wasserstein, MP | 1 |
Ahrends, R; Borst, O; Coman, C; Gawaz, M; Geue, S; Has, C; Hoffmann, N; Kopczynski, D; Lang, F; Manke, MC; Münzer, P; Peng, B; Sickmann, A | 1 |
Brea, RJ; Devaraj, NK; Fuertes, A; Podolsky, KA; Seoane, A | 1 |
Ge, D; Liu, HH; Yue, HW; Zhao, J | 1 |
Chang, F; Gao, J; Ge, D; Han, L; Li, Y; Liu, HH; Liu, J; Yang, WC; Yu, M; Zhao, J | 1 |
Aper, T; Böer, U; Haverich, A; Helms, F; Klingenberg, M; Lau, S; Wilhelmi, M | 1 |
Cho, Y; Kwon, OS; Son, J; Woo, JH; Yoon, SS | 1 |
Georgiev, G; Maslenkova, L; Momchilova, A; Pankov, R; Skrobanska, R; Stoyanova, T; Tsonchev, Z; Tzoneva, R; Uzunova, V | 1 |
Eto, Y; Higaki, K; Iwahori, A; Kato, A; Kikuchi, M; Maekawa, M; Mano, N; Narita, A; Noguchi, A; Ogura, J; Okuyama, T; Sato, T; Sato, Y; Takahashi, T | 1 |
Akiyama, K; Eto, Y; Hossain, MA; Igarashi, J; Iwamoto, T; Miyajima, T; Wu, C | 1 |
Kong, WH; Li, Y; Lu, CC; Qi, Q; Yang, WC; Yao, YJ; Zhang, TL; Zhao, J | 1 |
Alayoubi, A; Auray-Blais, C; Boutin, M; Menkovic, I; Mercier, FE; Rivard, GÉ | 1 |
Kong, W; Lu, C; Sun, W; Yao, Y; Zhao, J; Zhou, J | 1 |
Bae, YS; Cho, KM; Choi, CY; Kim, H; Kim, HH; Kim, KK; Kim, MK; Lee, HY; Lee, M; Park, JS | 1 |
Kitazawa, K; Kubota, Y; Musashi, M; Nagasawa, T; Nagasawa-Shimura, N; Tanaka, K; Yamaguchi, Y | 1 |
Kishi, H; Kobayashi, S; Lu, Q; Morita, T; Zhang, Y | 1 |
Bae, YS; Cho, KH; Cho, ML; Choi, J; Kim, DS; Kwok, SK; Lee, KH; Na, HS; Park, SH | 1 |
Kong, W; Li, Z; Lu, Y; Wang, Z; Zhao, J; Zhou, J | 1 |
Chen, H; Chen, K; Chen, L; Hu, Y; Huang, D; Jin, S; Ju, M; Li, R; Liu, L; Luan, C; Wang, Z; Zhang, J; Zhou, X | 1 |
18 review(s) available for phosphorylcholine and sphingosine
Article | Year |
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Sphingolipid metabolites: members of a new class of lipid second messengers.
Topics: Animals; Calcium; Cyclic AMP; Growth Substances; Humans; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Mice; Mitosis; Models, Biological; Phosphatidic Acids; Phosphorylcholine; Protein Kinase C; Rats; Second Messenger Systems; Sphingolipidoses; Sphingolipids; Sphingosine; Transcription Factor AP-1 | 1995 |
[Niemann-Pick disease types A and B].
Topics: Animals; Cell Differentiation; Ceramides; Glycoproteins; Humans; Lysosomes; Mice; Mutation; Niemann-Pick Diseases; Phosphorylcholine; Saposins; Signal Transduction; Sphingolipid Activator Proteins; Sphingomyelin Phosphodiesterase; Sphingosine | 1995 |
Tyrosine phosphorylation in the action of neuropeptides and growth factors.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Humans; Lysophospholipids; Neuropeptides; Paxillin; Phosphoproteins; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Sphingosine; Tyrosine | 1997 |
Structure activity relationships of lysophospholipid mediators.
Topics: Drug Industry; Lysophospholipids; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine | 2001 |
Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.
Topics: Animals; GTP-Binding Proteins; Humans; Lysophosphatidylcholines; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingosine | 2002 |
Sphingosylphosphorylcholine-biological functions and mechanisms of action.
Topics: Animals; Calcium Signaling; GTP-Binding Proteins; Humans; Lysophospholipids; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingosine | 2002 |
Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands.
Topics: Amino Acid Sequence; Animals; Humans; Molecular Sequence Data; Phosphorylcholine; Phylogeny; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sequence Homology, Amino Acid; Sphingosine | 2004 |
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
Topics: Animals; Cell Proliferation; Glomerular Mesangium; Humans; Kidney Diseases; Lysophosphatidylcholines; Lysophospholipids; Models, Biological; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Signal Transduction; Sphingosine | 2005 |
Two ligands for a GPCR, proton vs lysolipid.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Humans; Ligands; Lysophosphatidylcholines; Molecular Sequence Data; Phosphorylcholine; Protons; Psychosine; Receptors, G-Protein-Coupled; Sequence Alignment; Signal Transduction; Sphingosine | 2005 |
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine.
Topics: Animals; Blood Vessels; Calcium; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Lysophospholipids; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine; Vasoconstriction; Vasodilation | 2006 |
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
Topics: Animals; Biomechanical Phenomena; Cell Line, Tumor; Elasticity; Erythrocyte Deformability; Erythrocytes; Gastrointestinal Neoplasms; Humans; In Vitro Techniques; Lysophospholipids; Malaria; Pancreatic Neoplasms; Phosphorylcholine; Plasmodium falciparum; Sphingosine | 2005 |
Vascular effects of sphingolipids.
Topics: Humans; Lysophospholipids; Phosphorylcholine; Sphingolipids; Sphingosine; Vasoconstriction; Vasodilation | 2007 |
[Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction].
Topics: Animals; Calcium; Cardiovascular Diseases; Cholesterol; Humans; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Muscle, Smooth, Vascular; Phosphorylcholine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fyn; rho-Associated Kinases; Signal Transduction; Sphingosine; src-Family Kinases | 2007 |
The multi-functional role of sphingosylphosphorylcholine.
Topics: Animals; Blood Vessels; Calcium; Extracellular Signal-Regulated MAP Kinases; Humans; Immune System; Myocardium; Neurons; Phosphorylcholine; Signal Transduction; Skin; Sphingosine | 2008 |
A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Topics: Amidohydrolases; Ceramides; Dermatitis, Atopic; Epidermis; Glucosylceramides; Humans; Phosphorylcholine; Psychosine; Sphingomyelins; Sphingosine | 2009 |
Lipids as targets for novel anti-inflammatory therapies.
Topics: Animals; Anti-Inflammatory Agents; Cannabinoids; Fatty Acids, Unsaturated; Humans; Leukotriene Antagonists; Lipids; Lipoxins; Peroxisome Proliferator-Activated Receptors; Phospholipase A2 Inhibitors; Phosphorylcholine; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sphingolipids; Sphingosine | 2009 |
Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review.
Topics: Age of Onset; Bile Acids and Salts; Biomarkers; Carrier Proteins; Cholestanes; Genetic Testing; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Phosphorylcholine; Sphingosine; Vesicular Transport Proteins | 2016 |
Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases.
Topics: Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Endothelial Cells; Humans; Muscle Cells; Muscle, Smooth, Vascular; Phosphorylcholine; Signal Transduction; Sphingosine | 2018 |
2 trial(s) available for phosphorylcholine and sphingosine
Article | Year |
---|---|
A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study.
Topics: Aged; Arachidonic Acid; Cardiovascular Agents; Combined Modality Therapy; Eicosapentaenoic Acid; Female; Humans; Male; Middle Aged; Odds Ratio; Phosphorylcholine; Prospective Studies; rho-Associated Kinases; Signal Transduction; Sphingosine; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracranial | 2014 |
Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.
Topics: Adult; Biomarkers; Bone Density; Enzyme Replacement Therapy; Female; Hexosaminidases; Humans; Lipids; Liver; Lung; Male; Niemann-Pick Disease, Type A; Phosphorylcholine; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Spleen; Treatment Outcome | 2018 |
258 other study(ies) available for phosphorylcholine and sphingosine
Article | Year |
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Lipids in tissues of the eye XI. Synthesis of sphingomyelin in the calf lens.
Topics: Animals; Cattle; Ceramides; Coenzyme A; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Epithelium; Lens, Crystalline; Liver; Microsomes; Phosphatidylcholines; Phosphorylcholine; Rats; Sphingomyelins; Sphingosine; Stearates; Transferases | 1976 |
Determination of the transbilayer distribution of fluorescent lipid analogues by nonradiative fluorescence resonance energy transfer.
Topics: 4-Chloro-7-nitrobenzofurazan; Energy Transfer; Fluorescent Dyes; Lipid Bilayers; Liposomes; Lysophospholipids; Models, Molecular; Molecular Structure; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorylcholine; Rhodamines; Spectrometry, Fluorescence; Sphingosine | 1992 |
Modulation of human lymphoblastoid B cell line by phorbol ester and sphingosine. A 31P-NMR study.
Topics: B-Lymphocytes; Cell Division; Cell Line, Transformed; Choline; Energy Metabolism; Enzyme Activation; Herpesvirus 4, Human; Humans; Magnetic Resonance Spectroscopy; Phorbol 12,13-Dibutyrate; Phospholipids; Phosphorylcholine; Protein Kinase C; Sphingosine | 1991 |
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; HeLa Cells; Humans; Insulin; Kinetics; Mice; Mitogens; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells.
Topics: Cell Adhesion; Cell Line; Ceramides; Macrophages; Phosphatidylcholines; Phospholipases; Phosphorylcholine; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Intracellular calcium release mediated by sphingosine derivatives generated in cells.
Topics: Adenosine Diphosphate; Animals; Calcimycin; Calcium; Cell Line; Kinetics; Phosphoric Monoester Hydrolases; Phosphorylcholine; Protein Kinase C; Second Messenger Systems; Sphingosine; Thermodynamics | 1990 |
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.
Topics: Animals; Cell Division; Cell Line; Choline; Gangliosides; Kinetics; Lipid Metabolism; Mice; Neuroblastoma; Phospholipids; Phosphorylcholine; Psychosine; Sphingosine; Tumor Cells, Cultured | 1990 |
Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cell Membrane; Cytosol; Diglycerides; Dogs; Enzyme Activation; Epinephrine; Hydrolysis; Isoquinolines; Kidney; Kinetics; Neomycin; Phosphatidylcholines; Phosphorylcholine; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Sphingosine | 1988 |
Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Choline; Erythrocytes; Hemolysis; Humans; Intracellular Membranes; Male; Mitochondria, Liver; Mitochondrial Swelling; Niemann-Pick Diseases; Oxygen Consumption; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains; Sphingosine | 1988 |
Partial synthesis and properties of a series of N-acyl sphingomyelins.
Topics: Acylation; Animals; Brain Chemistry; Calorimetry, Differential Scanning; Cattle; Hydrolysis; Magnetic Resonance Spectroscopy; Phosphorylcholine; Sphingomyelins; Sphingosine; Stereoisomerism; X-Ray Diffraction | 1987 |
Studies on the hydrophobic properties of sphingomyelinase.
Topics: Chromatography, Affinity; Glycoside Hydrolases; Hydrogen-Ion Concentration; Isoelectric Focusing; Octoxynol; Phosphoric Diester Hydrolases; Phosphorylcholine; Polyethylene Glycols; Sepharose; Sphingomyelin Phosphodiesterase; Sphingosine | 1981 |
Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations.
Topics: Acylation; Animals; Choline; Chromatography, Gas; Hydrolysis; Molecular Conformation; Phosphorylcholine; Sphingosine; Spinal Cord; Stereoisomerism; Swine; Type C Phospholipases | 1983 |
Modulation of smooth muscle contraction by sphingosylphosphorylcholine.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Digestive System; Digestive System Physiological Phenomena; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gastrointestinal Motility; Immunoblotting; Muscle, Smooth; Phosphorylcholine; Protein Kinase C; Rabbits; Sphingosine | 1995 |
Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cytochalasin D; DNA; DNA Replication; Egtazic Acid; Enzyme Activation; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphorylcholine; Protein Kinase C; Proteins; Sphingosine; Thymidine; Virulence Factors, Bordetella | 1995 |
Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway.
Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Blotting, Western; Bombesin; Botulinum Toxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Indoles; Kinetics; Maleimides; Mice; Microinjections; Paxillin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylcholine; Phosphotyrosine; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Signal Transduction; Sphingosine | 1995 |
Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.
Topics: Calcium; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; HL-60 Cells; Humans; Kinetics; Lysophospholipids; Neutrophils; Pertussis Toxin; Phosphorylcholine; Platelet Activating Factor; Psychosine; Pyrrolidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingomyelin Phosphodiesterase; Sphingosine; Type C Phospholipases; Uridine Triphosphate; Virulence Factors, Bordetella | 1995 |
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Division; Cell Nucleus; DNA; DNA-Binding Proteins; Humans; Male; Mice; Molecular Sequence Data; Niemann-Pick Diseases; Oligodeoxyribonucleotides; Phosphorylcholine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Salmon; Signal Transduction; Spermatozoa; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 1995 |
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores.
Topics: 3T3 Cells; Animals; Calcium; Fluorescent Dyes; Fura-2; Kinetics; Lysophospholipids; Mice; Osteoblasts; Phosphorylation; Phosphorylcholine; Psychosine; Sphingosine; Structure-Activity Relationship | 1995 |
Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes.
Topics: Animals; Brain; Calcium; Calcium Channels; Cattle; Cerebellum; Microsomes; Muscle Proteins; Palmitoyl Coenzyme A; Phosphorylcholine; Quaternary Ammonium Compounds; Ryanodine Receptor Calcium Release Channel; Sphingosine | 1995 |
Effect of sphingomyelin and antioxidants on the in vitro and in vivo DNA methylation.
Topics: Animals; Antioxidants; Base Composition; Butylated Hydroxytoluene; Cattle; Cell Nucleus; DNA; Methionine; Methylation; Nucleotides; Octoxynol; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Rats; Sphingomyelins; Sphingosine; Thymus Gland; Tritium | 1995 |
Effect of lysophospholipids on signaling in the human Jurkat T cell line.
Topics: Calcium; Cell Division; Cell Line; Humans; Interleukin-2; Intracellular Membranes; Lysophospholipids; Osmolar Concentration; Phosphorylcholine; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Sphingosine; T-Lymphocytes | 1995 |
Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha.
Topics: 3T3 Cells; Animals; Biological Transport; Blotting, Western; Carbon Radioisotopes; Choline; Dose-Response Relationship, Drug; Isoenzymes; Isotope Labeling; Mice; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Endothelium, Vascular; Female; Heparin; Humans; In Vitro Techniques; Ion Channel Gating; Kinetics; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphorylcholine; RNA, Messenger; Sphingolipids; Sphingosine; Time Factors; Xenopus laevis | 1995 |
Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine.
Topics: Cell Line; Cytosol; Humans; Molecular Structure; Phosphoproteins; Phosphorylcholine; Protein Kinases; Sphingosine; T-Lymphocytes; Tumor Cells, Cultured | 1994 |
Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells.
Topics: Animals; Arachidonic Acid; Biological Transport; Calcium; Cell Division; Cells, Cultured; Mitogens; Pertussis Toxin; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Thyroid Gland; Virulence Factors, Bordetella | 1994 |
Sphingosine mobilizes intracellular calcium in human neutrophils.
Topics: Biological Transport; Calcium; Cell Compartmentation; Cell Death; Dose-Response Relationship, Drug; Edetic Acid; Fluorescent Dyes; Fura-2; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Ionomycin; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylcholine; Saponins; Sphingosine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Calcium; Cell Division; Cyclic AMP; Growth Substances; Lysophospholipids; Mice; Phosphatidylinositols; Phosphorylcholine; Protein Kinase C; Signal Transduction; Sphingosine | 1993 |
Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells.
Topics: Animals; Cell Differentiation; Mice; Neurites; Neuroblastoma; Phosphorylcholine; Protein Kinase C; Sphingosine; Tritium; Tumor Cells, Cultured | 1993 |
Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi.
Topics: Animals; Carbohydrate Conformation; Carbohydrate Sequence; Ceramides; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids; Glycolipids; Glycosphingolipids; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Oligochaeta; Oligosaccharides; Phosphorylcholine; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Sphingosine | 1995 |
A new wound healing agent--sphingosylphosphorylcholine.
Topics: Animals; Cell Division; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphorylcholine; Sphingosine; Time Factors; Wound Healing; Wounds and Injuries | 1996 |
The biological activity of acetylated sphingosylphosphorylcholine derivatives.
Topics: Acetylation; Adenosine Triphosphate; Animals; Glycogen; Logistic Models; Phosphorylcholine; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Serotonin; Sphingomyelins; Sphingosine; Tetrahymena pyriformis | 1996 |
A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.
Topics: Calcium; Cell Division; GTP-Binding Proteins; HL-60 Cells; Humans; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Phosphorylcholine; Sphingosine; Superoxides; Type C Phospholipases | 1996 |
Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency?
Topics: Amidohydrolases; Ceramides; Dermatitis, Atopic; Humans; Hydrolysis; Phosphorylcholine; Sphingomyelins; Sphingosine | 1996 |
Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung.
Topics: Amidohydrolases; Animals; Base Sequence; Betamethasone; Blotting, Southern; Ceramidases; Choline-Phosphate Cytidylyltransferase; Cycloserine; Glucocorticoids; Kinetics; Lung; Male; Molecular Sequence Data; Nucleotidyltransferases; Phospholipids; Phosphorylcholine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Up-Regulation | 1996 |
Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Cerebellum; In Vitro Techniques; Male; Membranes; Microsomes; Mitochondria; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sphingosine; Tumor Cells, Cultured | 1996 |
Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes.
Topics: Animals; Calcium; Electric Conductivity; Myocardium; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sodium; Sphingosine; Ventricular Function | 1996 |
Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Division; Consensus Sequence; DNA; Lysophospholipids; Mice; Molecular Sequence Data; Phosphorylcholine; Sphingolipids; Sphingosine; Structure-Activity Relationship; Transcription Factor AP-1 | 1996 |
Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lysophosphatidylcholines; Male; Phenanthridines; Phosphorylcholine; Pituitary Gland, Anterior; Platelet Activating Factor; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine | 1996 |
A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.
Topics: Animals; Electrophysiology; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guinea Pigs; Heart Atria; Lysophospholipids; Magnetic Resonance Spectroscopy; Models, Molecular; Pertussis Toxin; Phosphorylcholine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Virulence Factors, Bordetella | 1996 |
Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; GTP-Binding Proteins; Lysophospholipids; Pertussis Toxin; Phospholipases; Phosphorylcholine; Receptors, Cell Surface; Signal Transduction; Sphingolipids; Sphingosine; Virulence Factors, Bordetella | 1996 |
Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes.
Topics: Animals; Brain; Calcium; Fluorescent Dyes; Fura-2; Ion Transport; Microsomes; Phosphorylcholine; Rats; Rats, Wistar; Signal Transduction; Sphingosine | 1996 |
ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate.
Topics: 3T3 Cells; Adenosine Triphosphate; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; DNA; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Harvey murine sarcoma virus; Immunosuppressive Agents; Insulin; Kinetics; Lysophospholipids; Mice; Models, Biological; Phosphatidylinositol 3-Kinases; Phospholipases A; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Sphingosine; Thymidine; Transfection; Wortmannin | 1997 |
Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes.
Topics: Animals; Calcium; Calcium Channels; Dogs; Dose-Response Relationship, Drug; Intracellular Membranes; Microsomes; Muscle Proteins; Myocardium; Phosphorylcholine; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sphingosine | 1997 |
Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions.
Topics: 3T3 Cells; Animals; Cattle; Cell Culture Techniques; Cell Cycle; Cell Division; Ceramides; DNA; Humans; Lysophospholipids; Mice; Nucleic Acid Synthesis Inhibitors; Pancreatic Neoplasms; Phosphorylcholine; Serum Albumin; Sphingosine; Tumor Cells, Cultured | 1997 |
Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
Topics: Calcium; Enzyme Activation; Factor XIII; Guanosine Triphosphate; Humans; Phosphorylcholine; Sphingosine; Transglutaminases; Trypsin | 1997 |
Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Drug Synergism; Epidermis; Ethanolamine; Ethanolamines; Lysophospholipids; Mice; Mitogens; Phosphorylcholine; Sphingosine | 1997 |
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism.
Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Cell Line; Humans; Inositol Phosphates; Lysophospholipids; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
Topics: 3T3 Cells; Animals; Bridged-Ring Compounds; Choline; Diglycerides; Enzyme Activation; Homeostasis; Inositol Phosphates; Interleukin-6; Kinetics; Lysophospholipids; Mice; Norbornanes; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase C; Sphingosine; Thiocarbamates; Thiones; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1997 |
Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589.
Topics: Amidohydrolases; Chromatography, Thin Layer; Gram-Negative Facultatively Anaerobic Rods; Magnetic Resonance Spectroscopy; Phosphorylcholine; Spectrometry, Mass, Fast Atom Bombardment; Sphingosine; Stereoisomerism | 1997 |
Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells.
Topics: Amiloride; Animals; Anti-Bacterial Agents; Cells, Cultured; Deoxyglucose; Hydrogen; Hydrogen-Ion Concentration; Macrolides; Nigericin; Ouabain; Phosphorylcholine; Pituitary Gland; Polymerase Chain Reaction; Rats; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine | 1997 |
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
Topics: Animals; Cholesterol Esters; Glioma; Kinetics; Microsomes; Microsomes, Liver; Nitrogenous Group Transferases; Phosphatidylserines; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1997 |
Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes.
Topics: Animals; Calcium; Cell Division; Cell Membrane; Cells, Cultured; Diabetes Mellitus; DNA; Female; Humans; Intracellular Membranes; Keratinocytes; Mice; Mice, Inbred C57BL; Phosphorylcholine; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Skin; Sphingosine; Urokinase-Type Plasminogen Activator; Wound Healing; Wounds, Penetrating | 1998 |
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein.
Topics: 3T3 Cells; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Leucine Zippers; Mice; Mitogens; Nuclear Proteins; Phosphorylation; Phosphorylcholine; Protein Binding; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sphingosine; Temperature; Transcription Factors; Upstream Stimulatory Factors | 1998 |
The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Choline Kinase; DNA; Drug Interactions; Enzyme Inhibitors; Fibroblast Growth Factors; Hemicholinium 3; Insulin; Kinetics; Lysophospholipids; Mice; Mitogens; Phosphorylcholine; Sphingosine | 1998 |
Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.
Topics: Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Guanine Nucleotides; Humans; Insulinoma; Lysophospholipids; Phosphorylcholine; Potassium Chloride; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Sphingosine; Tumor Cells, Cultured | 1998 |
Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Bombesin; Calcium; Cell Adhesion Molecules; Cytochalasin D; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lysophospholipids; Mice; Molecular Sequence Data; Phosphorylcholine; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Vasopressins | 1998 |
Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine.
Topics: Animals; Binding Sites; Calcium; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Endothelium, Vascular; Humans; Kidney; Phosphorylcholine; Receptors, Cell Surface; Saponins; Sphingolipids; Sphingosine; Stereoisomerism | 1998 |
Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.
Topics: Arachidonic Acid; Bradykinin; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cell Membrane Permeability; Diglycerides; Epithelial Cells; Humans; Inositol Phosphates; Intracellular Fluid; Phosphatidic Acids; Phospholipids; Phosphorylcholine; Respiratory System; Sphingosine; Thapsigargin | 1998 |
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; DNA; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Swine; Thapsigargin; Virulence Factors, Bordetella | 1998 |
Digestion of ceramide by human milk bile salt-stimulated lipase.
Topics: Amidohydrolases; Ceramidases; Ceramides; Digestion; Fatty Acids; Humans; Hydrolysis; Milk, Human; Phosphorylcholine; Sphingosine; Sterol Esterase | 1998 |
Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Enzyme Inhibitors; Gallic Acid; Imidazoles; Leukocytes; Male; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Staurosporine; Synaptosomes | 1998 |
Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells.
Topics: Animals; Arachidonic Acid; Calcium; Glomerular Mesangium; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Male; Manganese; Phospholipases A; Phospholipases A2; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine | 1998 |
Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Keratinocytes; Phosphorylcholine; RNA, Messenger; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells.
Topics: Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Epithelial Cells; GTP-Binding Proteins; Histamine; Humans; Inositol Phosphates; Lysophospholipids; Magnesium; Nasal Cavity; Palmitic Acid; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Staurosporine; Thapsigargin; Time Factors; Virulence Factors, Bordetella | 1998 |
Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B.
Topics: Brain; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Liver; Niemann-Pick Diseases; Phosphorylcholine; Sensitivity and Specificity; Sphingosine; Spleen | 1999 |
DNA-induced endocytosis upon local microinjection to giant unilamellar cationic vesicles.
Topics: Animals; Cations; Cattle; DNA; Endocytosis; Liposomes; Membrane Lipids; Microinjections; Microscopy, Phase-Contrast; Optics and Photonics; Phosphorylcholine; Sphingosine | 1999 |
Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Nucleus; Estrenes; Heparin; In Vitro Techniques; Kinetics; Nimodipine; Phosphorylcholine; Pyrrolidinones; Rats; Sphingosine; Thapsigargin; Type C Phospholipases | 1999 |
Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange.
Topics: Animals; Base Sequence; Biopolymers; Calcium; Cell Line; DNA Primers; GTP-Binding Proteins; Ion Transport; Phosphorylcholine; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1999 |
EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cyclic AMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Humans; I-kappa B Proteins; Immediate-Early Proteins; Inositol Phosphates; Lysophospholipids; NF-KappaB Inhibitor alpha; Phosphorylcholine; Proprotein Convertases; Protein Kinase C; ras Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Serine Endopeptidases; Signal Transduction; Sphingosine | 1999 |
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells.
Topics: Brain Neoplasms; Enzyme Activation; Glioma; Lysophospholipids; Phospholipase D; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells.
Topics: Brain Neoplasms; Glioma; Homeostasis; Lysophospholipids; Phosphorylcholine; Sphingosine; Tumor Cells, Cultured | 1999 |
Sphingosylphosphorylcholine induces cytosolic Ca(2+) elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery.
Topics: Animals; Calcium; Calcium Signaling; Cattle; Coronary Vessels; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Phosphorylcholine; Polymethacrylic Acids; Sphingosine; Vasodilation | 1999 |
Lysosphingomyelin prevents behavioral aberrations and hippocampal neuron loss induced by the metabotropic glutamate receptor agonist quisqualate.
Topics: Animals; Behavior, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Lateral Ventricles; Male; Microtubule-Associated Proteins; Neurons; Phosphorylcholine; Quisqualic Acid; Rats; Rats, Inbred F344; Receptors, Metabotropic Glutamate; Seizures; Sphingosine | 1999 |
Modulation of T-lymphocyte proliferation by exogenous natural ceramides and sphingosylphosphorylcholine.
Topics: Animals; Cell Division; Cells, Cultured; Ceramides; Concanavalin A; DNA Replication; Female; Mice; Mice, Inbred BALB C; Phosphorylcholine; Sphingosine; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1999 |
Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptor.
Topics: Animals; Ion Channel Gating; Myocardium; Phosphorylcholine; Rabbits; Respiratory Burst; Ryanodine Receptor Calcium Release Channel; Sphingosine; Time Factors; Wound Healing | 1999 |
Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Cell Size; Endothelin-1; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Heart; Hypertrophy; Isoproterenol; MAP Kinase Signaling System; Muscle Proteins; Myocardium; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Protein Processing, Post-Translational; Rats; Sphingosine; Virulence Factors, Bordetella | 1999 |
Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility.
Topics: Actins; Calcium; Carcinoma; Cell Division; Cell Movement; Cyclic AMP; GTP-Binding Proteins; Humans; Lysophospholipids; Phospholipase D; Phosphorylcholine; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingolipids; Sphingosine; Thrombin; Tumor Cells, Cultured; Type C Phospholipases; Urinary Bladder Neoplasms | 2000 |
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic AMP; Egtazic Acid; Estrenes; Imidazoles; Ionomycin; Manganese; Muscle, Smooth, Vascular; Phosphorylcholine; Pyrrolidinones; Sphingosine; Staurosporine; Swine; Thapsigargin; Thionucleosides; Thionucleotides; Virulence Factors, Bordetella | 2000 |
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.
Topics: Calcium; Cloning, Molecular; Genes, Reporter; Green Fluorescent Proteins; Humans; Indicators and Reagents; Kidney; Ligands; Luminescent Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Sphingosine; Transfection; Tumor Cells, Cultured | 2000 |
Inhibition of cytokinesis by a lipid metabolite, psychosine.
Topics: Actins; Cell Division; Humans; Leukodystrophy, Globoid Cell; Phagocytosis; Phosphorylcholine; Psychosine; Sphingosine; Tumor Cells, Cultured; U937 Cells | 2000 |
Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate.
Topics: Animals; Base Sequence; DNA Primers; Guinea Pigs; Heart Rate; Phosphorylcholine; Potassium Channels; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine | 2000 |
Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis.
Topics: Animals; Aorta; Cattle; Cell Differentiation; Cell Size; Chemotaxis; Down-Regulation; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immediate-Early Proteins; Lymphokines; Lysophospholipids; Neovascularization, Physiologic; Phosphoric Monoester Hydrolases; Phosphorylcholine; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; rho GTP-Binding Proteins; RNA, Messenger; Sphingosine; Suramin; Time Factors; Umbilical Cord; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Virulence Factors, Bordetella | 2000 |
Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay.
Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Immediate-Early Proteins; Inhibitory Concentration 50; Kinetics; Lysophospholipids; Male; Phosphorylcholine; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Tissue Distribution; U937 Cells | 2000 |
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indomethacin; Lysophospholipids; Male; Mesenteric Arteries; Nitrendipine; Nitroarginine; Pertussis Toxin; Phosphorylcholine; Psychosine; Rats; Rats, Wistar; Renal Artery; Sphingosine; Vasoconstriction; Vasodilator Agents; Virulence Factors, Bordetella | 2000 |
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Kidney; Lysophospholipids; Male; Mesentery; Pertussis Toxin; Phosphorylcholine; Psychosine; Rats; Rats, Wistar; Renal Circulation; Sphingosine; Splanchnic Circulation; Virulence Factors, Bordetella | 2000 |
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.
Topics: Amides; Animals; Calcium; Coronary Vessels; Cytosol; Enzyme Inhibitors; Guanosine Triphosphate; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Potassium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Swine | 2000 |
Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux.
Topics: Apolipoprotein A-I; Calcium Signaling; Cells, Cultured; Cholesterol; DNA; Egtazic Acid; Enzyme Activation; Estrenes; Fibroblasts; Humans; Lipoproteins, HDL; Lysophospholipids; Mitogens; Nickel; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphorylcholine; Psychosine; Pyrrolidinones; Sphingolipids; Sphingosine; Tangier Disease; Type C Phospholipases | 2000 |
Methanolysis of sphingomyelin. Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine.
Topics: Kinetics; Magnetic Resonance Spectroscopy; Methane; Phosphorylcholine; Sphingomyelins; Sphingosine; Stereoisomerism; Temperature | 2000 |
Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells.
Topics: Animals; Baculoviridae; Calcium; Calpain; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanosine Triphosphate; Humans; Hydrolysis; Nitric Oxide; Phosphorylcholine; Recombinant Proteins; Sphingosine; Spodoptera; Transglutaminases | 2000 |
Inhibition of muscarinic potassium current by the class III antiarrhythmic drug RP58866 in guinea-pig atrial myocytes.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Chromans; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Myocardium; Patch-Clamp Techniques; Phosphorylcholine; Piperidines; Potassium; Receptor, Muscarinic M2; Receptors, Muscarinic; Sphingosine | 2000 |
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.
Topics: Calcium Signaling; Carbachol; Cell Line; Cholinergic Agonists; DNA-Binding Proteins; GTP-Binding Proteins; Humans; I-kappa B Proteins; Immediate-Early Proteins; Lysophospholipids; NF-KappaB Inhibitor alpha; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Type C Phospholipases | 2001 |
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors.
Topics: Animals; Blotting, Western; Carrier Proteins; Heart; Heart Atria; Phosphorylcholine; Precipitin Tests; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sphingosine | 2001 |
Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cations, Divalent; Cattle; Cells, Cultured; Cysteine; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Humans; Kinetics; Mercaptoethanol; Nitric Oxide; Nitroso Compounds; Phosphorylcholine; Platelet Aggregation; Protein Conformation; Protein Glutamine gamma Glutamyltransferase 2; Recombinant Proteins; S-Nitrosothiols; Sphingosine; Transglutaminases | 2001 |
Lysophospholipids increase interleukin-8 expression in ovarian cancer cells.
Topics: Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lysophospholipids; Ovarian Neoplasms; Phosphorylcholine; RNA, Messenger; Sphingosine; Tumor Cells, Cultured; Up-Regulation | 2001 |
Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.
Topics: Apoptosis; Arteriosclerosis; Cell Survival; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, HDL; Mitochondria; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Psychosine; Sphingosine | 2001 |
Immunology. The push-me pull-you of T cell activation.
Topics: Animals; Antigen Presentation; Antigens; Arteriosclerosis; B-Lymphocytes; Cell Cycle Proteins; Humans; Ligands; Lipoproteins, LDL; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lysophosphatidylcholines; Mice; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sphingosine; T-Lymphocytes | 2001 |
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
Topics: Animals; Arteriosclerosis; Calcium; Cell Cycle Proteins; Cell Line; Chemotaxis, Leukocyte; Humans; Jurkat Cells; Ligands; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Phosphorylcholine; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 2001 |
Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes.
Topics: Animals; Anticoagulants; Calcium; Calcium Channel Blockers; Heparin; Nimodipine; Phosphorylcholine; Psychosine; Rats; Ryanodine; Sphingolipids; Sphingosine; Synaptosomes | 2001 |
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium; CHO Cells; Cricetinae; DNA Primers; DNA Replication; Enzyme Activation; Humans; Ligands; Lysophosphatidylcholines; Mice; Mitogen-Activated Protein Kinases; Phosphorylcholine; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sphingosine; Transfection | 2001 |
Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes.
Topics: Calcium; Cathepsin D; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Humans; Keratinocytes; Phosphorylcholine; RNA, Messenger; Sphingosine; Thymidine; Time Factors; Transglutaminases | 2001 |
A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium Signaling; DNA, Complementary; GTP-Binding Proteins; Immediate-Early Proteins; Ion Channel Gating; Lysophospholipids; Mice; Molecular Sequence Data; Osteoblasts; Phosphorylcholine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; RNA, Messenger; Sphingolipids; Sphingosine | 2001 |
Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cell Line; Cricetinae; DNA, Complementary; Dogs; Evaluation Studies as Topic; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylcholine; Protein Conformation; Sphingosine | 2002 |
Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Drug Synergism; Enzyme Activation; Hydrogen Peroxide; Kinetics; Lysophospholipids; Mice; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine | 2002 |
Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells.
Topics: Cell Differentiation; Cell Division; Cell Fractionation; Cell Nucleus; Diglycerides; Dimethyl Sulfoxide; Ethanol; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Isoenzymes; Phospholipase D; Phosphorylcholine; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Solvents; Sphingosine; Tetradecanoylphorbol Acetate | 2002 |
New roads leading to Ca2+ sensitization.
Topics: Animals; Calcium Signaling; Cattle; Cerebral Arteries; Heterotrimeric GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphorylcholine; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Cell Surface; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Vasospasm, Intracranial | 2002 |
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.
Topics: Animals; Calcium Signaling; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Cerebral Arteries; Culture Techniques; Enzyme Inhibitors; Escin; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylcholine; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; Sphingosine | 2002 |
Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK.
Topics: Animals; Cats; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Ileum; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phosphorylcholine; Sphingosine | 2002 |
Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway.
Topics: Acylation; Animals; Blotting, Western; Calcium; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Muscle, Smooth, Vascular; Palmitates; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Wistar; rho-Associated Kinases; Second Messenger Systems; Signal Transduction; Sphingosine; src-Family Kinases; Swine; Vasoconstriction | 2002 |
Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
Topics: Adolescent; Adult; Ceramides; Dermatitis, Atopic; Epidermis; Humans; Phosphorylcholine; Psychosine; Sphingosine; Up-Regulation | 2003 |
Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Microcirculation; Norepinephrine; Phosphorylcholine; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Splanchnic Circulation; Vasoconstriction | 2003 |
Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts.
Topics: Antibodies; Cells, Cultured; Dermis; Fibroblasts; Fibronectins; Humans; Interleukin-6; Phosphorylcholine; Protein Biosynthesis; RNA, Messenger; Sphingosine; Transcription, Genetic; Up-Regulation | 2003 |
Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.
Topics: Blood Platelets; Calcium; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flow Cytometry; Humans; In Vitro Techniques; Phosphorylcholine; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Time Factors; Type C Phospholipases | 2003 |
Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Topics: Animals; Binding, Competitive; Brain; Cell Differentiation; Cell Division; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Situ Hybridization; Ligands; Mice; Neurons; Oocytes; Phosphorylcholine; Phylogeny; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Sphingosine; Stem Cells; Substrate Specificity; Synapses; Transfection; Xenopus | 2003 |
Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine.
Topics: Animals; Calcium; Heart; Ion Channel Gating; Kinetics; Lipid Bilayers; Membrane Potentials; Myocardium; Phosphorylcholine; Rabbits; Ryanodine Receptor Calcium Release Channel; Sphingosine | 2003 |
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).
Topics: Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Electrophysiology; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Muscles; NADP; Neuromuscular Junction; Neurotransmitter Agents; Phosphorylcholine; Rana pipiens; Sphingosine; Thapsigargin; Wound Healing | 2003 |
Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings.
Topics: Animals; Calcium; Carcinogens; Cattle; Drug Carriers; Drug Interactions; Inositol 1,4,5-Trisphosphate; Liposomes; Motor Endplate; Motor Neurons; Nerve Endings; Neurotransmitter Agents; Phosphorylcholine; Rana pipiens; Sphingosine; Thapsigargin | 2003 |
Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.
Topics: Adenoviridae; Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Movement; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genetic Vectors; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Ligands; Lysophospholipids; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Phosphorylcholine; Plasmids; Protein Isoforms; Pyrazoles; Pyridines; rac GTP-Binding Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Temperature; Time Factors | 2003 |
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
Topics: Actin Cytoskeleton; Carcinoma; Cell Movement; Cell Size; Cytoskeleton; Elasticity; Fluorescent Antibody Technique; Humans; Keratins; Microscopy, Electron; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphorylcholine; Sphingosine; Stress, Mechanical; Tumor Cells, Cultured | 2003 |
The reported occurrence of sphingosylphosphorylcholine in animal tissues.
Topics: Animals; Choline; Phospholipids; Phosphorylcholine; Sphingosine | 1958 |
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Topics: 3T3 Cells; Animals; Catalysis; Cell Movement; Chlorocebus aethiops; COS Cells; Glucose-6-Phosphate Isomerase; Glycoproteins; Hydrolysis; Lysophospholipids; Mice; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylcholine; Pyrophosphatases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; rho GTP-Binding Proteins; Sphingosine | 2003 |
Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes.
Topics: Cell Division; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Humans; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-kit; Receptors, Endothelin; RNA, Messenger; Sphingosine; Stem Cell Factor; Transcription Factors | 2003 |
Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes.
Topics: 4-Aminobenzoic Acid; ADP Ribose Transferases; Amidohydrolases; Animals; Bacterial Toxins; Botulinum Toxins; Calcium-Binding Proteins; Ceramidases; Chromatography, Thin Layer; Diglycerides; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Erythrocytes; Ethanolamines; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hemolysis; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Oleic Acids; para-Aminobenzoates; Pertussis Toxin; Phosphatidylcholines; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Rabbits; Sheep; Sphingomyelins; Sphingosine; Time Factors; Toxins, Biological; Type C Phospholipases | 2004 |
Sphingolipids as bioactive regulators of thrombin generation.
Topics: Anticoagulants; Binding Sites; Blood Platelets; Carbon; Dose-Response Relationship, Drug; Down-Regulation; Factor Va; Factor Xa; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Lipid Metabolism; Lipids; Micelles; Phosphorylcholine; Protein Binding; Protein Structure, Tertiary; Prothrombin; Psychosine; Sphingolipids; Sphingosine; Thrombin | 2004 |
Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.
Topics: Cell Line; Humans; Hydrolysis; Kidney; Kinetics; Molecular Sequence Data; Phospholipids; Phosphorylcholine; Sphingomyelin Phosphodiesterase; Sphingosine; Substrate Specificity; Type C Phospholipases | 2004 |
The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ion Channel Gating; Kv1.3 Potassium Channel; Membrane Potentials; Phosphorylcholine; Potassium Channels, Voltage-Gated; Sphingosine; T-Lymphocytes; Zinc | 2004 |
The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine.
Topics: Lysophospholipids; Micelles; Molecular Structure; Phosphorylcholine; Sodium Chloride; Sphingosine; Water | 2004 |
Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts.
Topics: Animals; Calcium; Cells, Cultured; Dermis; Fibroblasts; Gene Expression; GTP-Binding Proteins; Humans; MAP Kinase Signaling System; Phosphorylcholine; Plasminogen Activator Inhibitor 1; Protein Kinase C; Rabbits; Sphingosine; Wound Healing | 2004 |
A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling.
Topics: Animals; Burns, Chemical; Caustics; Collagen; Contrast Media; Disease Models, Animal; Esophageal Stenosis; Esophagus; Female; Hydroxyproline; Mucous Membrane; Muscle, Smooth; Phosphorylcholine; Radiography; Rats; Rats, Wistar; Second Messenger Systems; Sodium Hydroxide; Sphingosine; Treatment Outcome; Wound Healing | 2004 |
G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.
Topics: Actins; Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Line; Cloning, Molecular; COS Cells; Flow Cytometry; Genes, Reporter; Histidine; Humans; Hydrogen-Ion Concentration; Immunoprecipitation; Inositol Phosphates; Ligands; Lysophosphatidylcholines; Mice; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis, Site-Directed; NIH 3T3 Cells; PC12 Cells; Phosphorylcholine; Promoter Regions, Genetic; Protons; Rats; Receptors, G-Protein-Coupled; Sequence Homology, Amino Acid; Signal Transduction; Sphingosine; Time Factors; Transfection | 2004 |
Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Lysophospholipids; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Norepinephrine; Phosphorylcholine; Potassium Chloride; Rats; Rats, Wistar; Sphingolipids; Sphingosine; Vasoconstrictor Agents | 2004 |
Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways.
Topics: Animals; Calcium; Cell Line; Chlorocebus aethiops; COS Cells; Endothelial Cells; Phospholipase D; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-delta; Reactive Oxygen Species; Signal Transduction; Sphingosine; Type C Phospholipases | 2005 |
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Blotting, Northern; Blotting, Western; Brain; Cations; Cell Membrane; Cell Movement; Fatty Acids; Glycerylphosphorylcholine; HeLa Cells; Humans; Hydrolysis; Immunohistochemistry; Kidney; Kinetics; Lysophosphatidylcholines; Mice; Microscopy, Fluorescence; Models, Biological; Models, Chemical; Molecular Sequence Data; Myocardium; Nephrons; Phospholipids; Phosphoric Diester Hydrolases; Phosphorylcholine; Phylogeny; Protein Binding; Protein Structure, Tertiary; Pyrophosphatases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity; Sphingomyelin Phosphodiesterase; Sphingosine; Swine; Time Factors; Tissue Distribution; Transfection; Type C Phospholipases | 2005 |
Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis.
Topics: Animals; Aorta; Capillaries; Cell Movement; Cells, Cultured; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Neovascularization, Physiologic; Phosphorylcholine; Rats; Rats, Inbred F344; Sphingosine; Umbilical Veins; Urokinase-Type Plasminogen Activator; Wound Healing | 2005 |
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.
Topics: Animals; Antibodies; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chick Embryo; Endothelial Cells; Enzyme Activation; Gene Expression; Humans; Hydrogen-Ion Concentration; Lysophospholipids; Neovascularization, Physiologic; Oncogene Protein v-akt; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; RNA, Small Interfering; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A | 2005 |
Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells.
Topics: Adipose Tissue; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cytochromes c; Humans; MAP Kinase Signaling System; Phosphorylcholine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sphingosine; Stem Cells | 2005 |
Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue.
Topics: Carbon Isotopes; Combinatorial Chemistry Techniques; Molecular Structure; Phosphorylcholine; Photochemistry; Sphingosine; Stereoisomerism | 2005 |
Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts.
Topics: Base Sequence; Cells, Cultured; Connective Tissue Growth Factor; DNA, Complementary; Fibroblasts; Gene Expression; Gene Expression Profiling; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Oligonucleotide Array Sequence Analysis; Phosphorylcholine; RNA, Messenger; Signal Transduction; Skin; Sphingosine | 2005 |
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Topics: Amides; Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 1; In Vitro Techniques; Lanthanum; Lysophospholipids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylcholine; Pulmonary Artery; Pyridines; Rats; Sphingosine; Thapsigargin; Type C Phospholipases; Vasoconstriction | 2005 |
Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor.
Topics: Cell Cycle Proteins; Chemotaxis; Diterpenes; Fibrinolytic Agents; Flow Cytometry; Ginkgolides; Humans; Interferon-alpha; Interleukins; Killer Cells, Natural; Lactones; Lymphocyte Activation; Lysophosphatidylcholines; Pertussis Toxin; Phosphorylcholine; Platelet Activating Factor; Receptors, G-Protein-Coupled; Receptors, IgG; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine | 2005 |
Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
Topics: Amides; Animals; Biological Transport; Calcium; Cell Membrane; Enzyme Activation; G-Protein-Coupled Receptor Kinase 1; Humans; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Sphingosine; Vasoconstrictor Agents | 2005 |
A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate.
Topics: Blood Chemical Analysis; Ceramides; Chemistry, Clinical; Clinical Enzyme Tests; Diagnosis, Differential; Dose-Response Relationship, Drug; Fibroblasts; Fluorometry; Gene Expression Regulation, Enzymologic; Hexosaminidases; Humans; Hydrolysis; Leukocytes; Mutation; Niemann-Pick Diseases; Phospholipid Ethers; Phosphorylcholine; Protein Binding; Reproducibility of Results; Skin; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Substrate Specificity; Time Factors | 2005 |
Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Inositol Phosphates; Lysophosphatidylcholines; Phosphorylcholine; Psychosine; Receptors, G-Protein-Coupled; Second Messenger Systems; Sphingosine; Transfection; Type C Phospholipases | 2005 |
Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK.
Topics: Adipose Tissue; Calcium; Cell Proliferation; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophosphatidylcholines; MAP Kinase Kinase 4; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 9; Models, Biological; Pertussis Toxin; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Type C Phospholipases | 2006 |
Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Lysophospholipids; Male; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine | 2006 |
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Arteries; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Lysophospholipids; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingolipids; Sphingosine | 2006 |
Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient
Topics: Chromatography, Thin Layer; Fabry Disease; Heart Valves; Humans; Male; Middle Aged; Phosphorylcholine; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sphingosine | 2006 |
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C.
Topics: Boron Compounds; Calcium; Calcium Signaling; Cells, Cultured; Gadolinium; Gene Expression Regulation; Humans; Lysophospholipids; Phosphorylcholine; Protein Isoforms; Protein Kinase C; Protein Transport; Receptors, G-Protein-Coupled; RNA, Messenger; Sphingosine; Thapsigargin; Thymidine; Thyroid Gland; Tritium | 2006 |
Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine.
Topics: Animals; Blood Pressure; Diuresis; Heart Rate; Indomethacin; Kidney; Lysophospholipids; Male; Natriuresis; Neuropeptide Y; Pertussis Toxin; Phosphorylcholine; Rats; Rats, Wistar; Renal Circulation; Sphingosine | 2006 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Myosin Light Chains; Naphthalenes; Phosphorylation; Phosphorylcholine; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sphingosine; Vasoconstriction | 2006 |
Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.
Topics: Antioxidants; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Male; MAP Kinase Signaling System; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Phosphorylcholine; Pigmentation; Pyrones; Ribosomal Protein S6 Kinases, 90-kDa; Sphingosine | 2006 |
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.
Topics: Animals; Calcium; Cholesterol; Coronary Vessels; Female; Humans; Hypercholesterolemia; Intracellular Signaling Peptides and Proteins; Male; Membrane Microdomains; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Protein Serine-Threonine Kinases; Rabbits; rho-Associated Kinases; Sphingosine | 2006 |
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.
Topics: Binding Sites; Binding, Competitive; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Homeodomain Proteins; Humans; Phosphorylcholine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sphingosine; Steroid 17-alpha-Hydroxylase; Steroidogenic Factor 1; Transcription Factors; Transcription, Genetic | 2006 |
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Topics: Actins; Amides; Animals; Azepines; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Myosin Light Chains; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Pyridines; Signal Transduction; Sphingosine | 2006 |
The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
Topics: Actins; Animals; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Focal Adhesions; Humans; Leukemia, Promyelocytic, Acute; Mice; Phosphorylcholine; Receptors, G-Protein-Coupled; Sphingosine | 2007 |
Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis.
Topics: Chemotaxis; Dendritic Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Mitogen-Activated Protein Kinases; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine | 2006 |
Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells.
Topics: Animals; Cells, Cultured; Collagen; Gels; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Microscopy, Electron; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylcholine; Sphingosine | 2006 |
Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
Topics: Actins; Cell Differentiation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mesenchymal Stem Cells; Muscle, Smooth; Myocytes, Smooth Muscle; Nuclear Proteins; Phosphorylation; Phosphorylcholine; Serum Response Factor; Signal Transduction; Smad2 Protein; Sphingosine; Stress Fibers; Subcutaneous Fat; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid.
Topics: Aldehydes; Chlorine; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Lipoproteins, HDL; Lysophospholipids; Peroxidase; Phosphorylcholine; Sphingosine | 2007 |
Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK.
Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Humans; In Situ Nick-End Labeling; Mice; Nitriles; Phosphorylcholine; Reactive Oxygen Species; Signal Transduction; Sphingosine; Transfection | 2007 |
Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
Topics: Animals; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Activation; Epidermis; Fibroblasts; Flavonoids; Humans; Indoles; Interleukin-6; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Rabbits; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Wound Healing | 2007 |
Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12.
Topics: Antigens, CD; B7-2 Antigen; Calcium; CD83 Antigen; Cells, Cultured; Chemotaxis; Dendritic Cells; Endocytosis; HLA-DR Antigens; Humans; Immunoglobulins; Interferon-gamma; Interleukin-12; Interleukin-18; Lymphocyte Culture Test, Mixed; Membrane Glycoproteins; Phosphorylcholine; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine | 2007 |
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
Topics: Cell Line; Cell Line, Tumor; Cyclic AMP; ErbB Receptors; Humans; Hydrogen-Ion Concentration; Ligands; Lysophosphatidylcholines; NFATC Transcription Factors; Phosphorylcholine; Protons; Receptors, G-Protein-Coupled; Serum Response Element; Signal Transduction; Sphingosine | 2007 |
Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells.
Topics: Adult; Benzamides; Blotting, Western; Butadienes; Cell Adhesion; Cells, Cultured; Dioxoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibronectins; Gene Expression; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Nitriles; Phosphorylation; Phosphorylcholine; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Smad Proteins; Smad7 Protein; Sphingosine; Transforming Growth Factor beta1 | 2007 |
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Topics: Animals; Cells, Cultured; Dinoprostone; Interleukin-1beta; Mesangial Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylcholine; Rats; Signal Transduction; Smad Proteins; Sphingosine; Transforming Growth Factor beta | 2007 |
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; G2 Phase; Humans; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; Thyroid Neoplasms | 2007 |
Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Intracellular Signaling Peptides and Proteins; Methyl Ethers; Phosphorylcholine; Propofol; Protein Serine-Threonine Kinases; rho-Associated Kinases; Sevoflurane; Sphingosine; Swine; Vasoconstriction | 2007 |
Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.
Topics: Animals; Apoptosis; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Microscopy, Video; Necrosis; Nerve Degeneration; Neurotoxicity Syndromes; Niemann-Pick Disease, Type A; Phenotype; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine | 2007 |
Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Ethidium; Fluorometry; Humans; Interleukin-1beta; Lipids; Lysophosphatidylcholines; Mice; Octoxynol; Palmitoylcarnitine; Phosphorylcholine; Purinergic P2 Receptor Agonists; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X7; Sphingosine; Surface-Active Agents | 2007 |
Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries.
Topics: Amides; Animals; Basilar Artery; Calcium; Dinoprost; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Myosin Light Chains; Phosphorylation; Phosphorylcholine; Pyridines; Sphingosine; Vasodilation | 2007 |
Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells.
Topics: Animals; Apoptosis; Calcium; Cells, Cultured; Cerebellum; Mice; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylcholine; Rats; Sphingosine | 2007 |
Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts.
Topics: Actins; Animals; Fibroblasts; Humans; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Sphingosine; Stress Fibers; Transfection | 2007 |
Sphingosylphosphorylcholine as a novel calmodulin inhibitor.
Topics: Animals; Brain Chemistry; Calmodulin; Cattle; Liposomes; Micelles; Phosphorylcholine; Signal Transduction; Sphingosine; Tyrosine | 2008 |
Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.
Topics: Animals; Calcium; Calorimetry; Cattle; Cell Survival; Humans; Jurkat Cells; Membrane Potential, Mitochondrial; Phosphorylcholine; Reactive Oxygen Species; Serum Albumin, Bovine; Sphingosine; T-Lymphocytes | 2007 |
Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines.
Topics: Apoptosis; Calcium; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Lysophospholipids; Male; Phosphorylcholine; Prostatic Neoplasms; Sphingosine | 2007 |
Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry.
Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Dinoprost; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Enzyme Inhibitors; Intracellular Membranes; Male; Myocytes, Smooth Muscle; Osmolar Concentration; Phosphorylcholine; Potassium; Protein Kinase C-delta; Pulmonary Artery; Rats; Rats, Wistar; Sphingosine; Vasoconstriction; Vasomotor System | 2008 |
Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat.
Topics: Animals; Apoptosis; Cyclooxygenase 2; Cytokines; Drug Administration Schedule; Endotoxemia; Intercellular Adhesion Molecule-1; Lung; Male; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylcholine; Rats; Rats, Wistar; Sphingosine | 2008 |
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells.
Topics: Animals; Cats; Esophagus; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Muscle Contraction; Myocytes, Smooth Muscle; Phospholipase C beta; Phosphorylcholine; Protein Kinase C; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2007 |
Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.
Topics: Amides; Animals; Antipruritics; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Intradermal; Ketotifen; Male; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Naltrexone; Narcotic Antagonists; Phosphorylcholine; Pruritus; Pyridines; rho-Associated Kinases; Sphingosine | 2008 |
Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction.
Topics: Actins; Animals; Becaplermin; Cattle; Cell Line; Chemotaxis; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Fluorescent Antibody Technique; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Microscopy, Confocal; Microscopy, Electron; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Subfragments; Myosin Type II; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Conformation; Proto-Oncogene Proteins c-sis; Rats; Sphingosine | 2008 |
Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with
Topics: Child, Preschool; Gaucher Disease; Glucosylceramides; Humans; Liver; Niemann-Pick Diseases; Phosphorylcholine; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingomyelins; Sphingosine; Spleen | 2008 |
Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Angiography; Cisterna Magna; Disease Models, Animal; Dogs; Eicosapentaenoic Acid; Female; Injections; Male; Phosphorylcholine; Protein Kinase Inhibitors; rho-Associated Kinases; Signal Transduction; Sphingosine; Subarachnoid Hemorrhage; Time Factors; Vasoconstriction; Vasodilator Agents; Vasospasm, Intracranial | 2008 |
Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Line, Transformed; Down-Regulation; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lysophospholipids; Mice; Mice, Inbred C57BL; Microglia; Phosphorylcholine; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine | 2008 |
A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells.
Topics: Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Humans; Mesenchymal Stem Cells; Muscle Contraction; Myocytes, Smooth Muscle; Nuclear Proteins; Oncogene Proteins, Fusion; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Trans-Activators | 2008 |
Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; DNA Fragmentation; Flow Cytometry; Isoenzymes; Mice; Mitochondria; Neurons; Phosphorylcholine; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Subcellular Fractions | 2008 |
Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
Topics: Animals; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Lysophospholipids; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphorylation; Phosphorylcholine; Rabbits; rho-Associated Kinases; Sarcoplasmic Reticulum; Signal Transduction; Sphingosine | 2009 |
Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine.
Topics: Actins; Animals; Binding Sites; Cattle; Cell Line; Chemotaxis; Guinea Pigs; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Myosin Type II; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Protein Kinase Inhibitors; Pseudopodia; Rats; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Sphingosine; Transfection | 2009 |
Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats.
Topics: Analysis of Variance; Animals; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Immunohistochemistry; Ligation; Lipid Peroxidation; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Phosphorylcholine; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Sphingosine | 2009 |
Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Calibration; Chromatography, High Pressure Liquid; Dogs; Female; Humans; Kinetics; Male; Mass Spectrometry; Middle Aged; Phosphorylcholine; Regression Analysis; Solid Phase Extraction; Sphingosine; Subarachnoid Hemorrhage | 2009 |
Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava.
Topics: Animals; Ceramides; Chromatography, Thin Layer; Ciona intestinalis; Hydrolysis; Phosphorylcholine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Sphingomyelins; Sphingosine; Type C Phospholipases; Urochordata | 2009 |
Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin.
Topics: Animals; Calcium; Dermatitis, Atopic; Ganglia, Spinal; Histamine; Histamine H1 Antagonists, Non-Sedating; Injections, Intradermal; Keratinocytes; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Neurons; Phosphorylcholine; Pruritus; Skin; Sphingomyelins; Sphingosine; Terfenadine | 2009 |
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
Topics: Antigen Presentation; Antigen-Presenting Cells; Antigens, CD1d; Autoantigens; Cell Line; Cytokines; Humans; Inflammation; Lymphocyte Activation; Lysophosphatidylcholines; Natural Killer T-Cells; Phosphorylcholine; Signal Transduction; Sphingosine | 2009 |
Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice.
Topics: Animals; Dermatitis; Dose-Response Relationship, Drug; Ear; Histamine; Inflammation; Mast Cells; Mice; Mice, Inbred ICR; Phosphorylcholine; Skin; Sphingosine; Time Factors | 2010 |
Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.
Topics: Amino Acid Sequence; Animals; Apoproteins; Binding, Competitive; Calcium; Calcium Signaling; Calmodulin; Cattle; Humans; Intracellular Space; Kinetics; Melitten; Micelles; Molecular Sequence Data; Phosphorylcholine; Protein Structure, Tertiary; Ryanodine Receptor Calcium Release Channel; Spectrometry, Fluorescence; Sphingosine | 2010 |
Differentiation of adult stem cells into smooth muscle for vascular tissue engineering.
Topics: Adult Stem Cells; Aged; Aged, 80 and over; Angiotensin II; Blood Vessel Prosthesis; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Calponins; Cell Culture Techniques; Cell Differentiation; Collagen; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocytes, Smooth Muscle; Myosin Heavy Chains; Phenotype; Phosphorylcholine; Sphingosine; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta | 2011 |
Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces.
Topics: Cholesterol; Lipid Bilayers; Microscopy, Fluorescence; Phosphatidylcholines; Phosphorylcholine; Silicon Dioxide; Sphingosine; Surface Properties; Temperature | 2010 |
Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes.
Topics: Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Keratinocytes; Membrane Proteins; NADPH Oxidase 5; NADPH Oxidases; Phosphorylcholine; Sphingosine | 2010 |
Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation.
Topics: Animals; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Membrane; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Immunoprecipitation; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Microscopy, Phase-Contrast; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine | 2010 |
Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries.
Topics: Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Cerebral Arteries; Chemokine CCL2; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Inflammation; Inflammation Mediators; Lysophospholipids; Male; Muscle, Smooth, Vascular; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine; Subarachnoid Hemorrhage; Transcription Factors; Up-Regulation; Vasospasm, Intracranial | 2011 |
[Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery].
Topics: Animals; Drug Synergism; Ethanol; In Vitro Techniques; Male; Phosphorylcholine; Rats; Sphingosine; Vasoconstriction | 2010 |
Development of a sphingosylphosphorylcholine detection system using RNA aptamers.
Topics: Aptamers, Nucleotide; Base Sequence; Biological Assay; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Phosphorylcholine; Reproducibility of Results; SELEX Aptamer Technique; Sphingosine; Surface Plasmon Resonance | 2010 |
Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms.
Topics: Animals; Calmodulin; Muscle, Skeletal; Permeability; Phosphorylcholine; Rabbits; Ryanodine Receptor Calcium Release Channel; Sphingosine | 2010 |
Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
Topics: Base Sequence; Calcium; Cell Differentiation; Cell Line; DNA Primers; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Macrophages; MAP Kinase Signaling System; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Psychosine; raf Kinases; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; U937 Cells | 2011 |
Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.
Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart; Humans; Lipoproteins, HDL; Lysophospholipids; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phosphorylcholine; Rats; Sphingosine | 2010 |
Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells.
Topics: Apoptosis; Autophagy; Cells, Cultured; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Integrin beta4; Phosphorylcholine; Sphingosine; Tumor Suppressor Protein p53; Type C Phospholipases | 2011 |
Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.
Topics: Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Humans; Membrane Lipids; Pertussis Toxin; Phosphorylcholine; Signal Transduction; Sphingosine; Umbilical Veins | 2011 |
Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Down-Regulation; Humans; Lysophospholipids; NF-kappa B; PC12 Cells; Phosphorylcholine; Rats; Sphingosine | 2011 |
Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions.
Topics: Administration, Topical; Animals; Arachidonate 5-Lipoxygenase; Dermatitis, Atopic; Disease Models, Animal; Leukotriene B4; Mice; Phenylpropionates; Phosphorylcholine; Pruritus; Receptors, Leukotriene B4; Skin; Sphingosine | 2011 |
Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Hypopigmentation; Luciferases; Melanins; Mice; Microscopy, Phase-Contrast; Monophenol Monooxygenase; Morpholines; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Sphingosine; TOR Serine-Threonine Kinases; Transfection | 2011 |
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Movement; Cystamine; Cytoskeleton; Gene Expression Regulation, Neoplastic; Gene Silencing; GTP-Binding Proteins; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Keratin-8; MAP Kinase Signaling System; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Glutamine gamma Glutamyltransferase 2; Protein Kinase Inhibitors; RNA, Small Interfering; Serine; Sphingosine; Transglutaminases | 2011 |
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.
Topics: ADP Ribose Transferases; Amino Acid Substitution; Animals; Botulinum Toxins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesions; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Pseudopodia; Recombinant Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Stress Fibers | 2012 |
Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.
Topics: Amides; Blotting, Western; Cell Differentiation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Phosphorylcholine; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Sphingosine | 2012 |
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn.
Topics: Animals; Cells, Cultured; Coculture Techniques; Endothelial Cells; Humans; Integrin beta4; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; rho-Associated Kinases; RNA, Small Interfering; Sphingosine | 2012 |
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
Topics: Cell Line, Tumor; Cell Movement; Cytoskeleton; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Intermediate Filaments; Keratin-8; MAP Kinase Kinase Kinases; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Kinase Inhibitors; Serine; Signal Transduction; Sphingosine; Stomach Neoplasms | 2012 |
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
Topics: Animals; Cell Line; Dual Specificity Phosphatase 6; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypopigmentation; MAP Kinase Signaling System; Melanins; Mice; Phosphorylation; Phosphorylcholine; Protein Phosphatase 2; Protein Processing, Post-Translational; Sphingosine | 2012 |
The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes.
Topics: Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclin B; Female; Meiosis; Meiotic Prophase I; Metaphase; Microscopy, Fluorescence; Nuclear Envelope; Oocytes; Phosphorylcholine; Receptors, G-Protein-Coupled; RNA Interference; Signal Transduction; Sphingosine; Swine; Time Factors | 2012 |
Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study.
Topics: Cholesterol; Glycyrrhizic Acid; Membrane Microdomains; Microscopy, Fluorescence; Phosphatidylcholines; Phosphorylcholine; Sphingosine | 2013 |
Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients.
Topics: Blood Cells; Case-Control Studies; Dried Blood Spot Testing; Humans; Lysosomes; Macrophages; Niemann-Pick Disease, Type B; Phosphorylcholine; Sphingomyelin Phosphodiesterase; Sphingosine | 2014 |
Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway.
Topics: Actins; Airway Remodeling; Cells, Cultured; Collagen; Fibroblasts; Gels; Humans; Lung; Phosphorylcholine; Receptors, Lysosphingolipid; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Transcriptional Activation; Transforming Growth Factor beta1 | 2014 |
Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells.
Topics: Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Phosphorylcholine; Sphingosine | 2014 |
Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Specimen Collection; Case-Control Studies; Edetic Acid; Female; Heparin; Humans; Male; Niemann-Pick Disease, Type C; Phosphorylcholine; Psychosine; Reproducibility of Results; Retrospective Studies; Sphingosine; Tandem Mass Spectrometry; Young Adult | 2014 |
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
Topics: Amides; Animals; Antihypertensive Agents; Basilar Artery; beta-Cyclodextrins; Carotid Artery, Internal; Cholesterol; Dietary Fats; Male; Membrane Microdomains; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Sphingosine; Vasospasm, Intracranial | 2015 |
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species.
Topics: Animals; Calcium Channels; Cyclic N-Oxides; Dose-Response Relationship, Drug; Membrane Glycoproteins; Mesenteric Arteries; Mice; Mice, Knockout; Models, Animal; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphorylcholine; Protein Kinase C-epsilon; Pulmonary Artery; Reactive Oxygen Species; Signal Transduction; Sphingosine; Spin Labels; Type C Phospholipases; Vasoconstriction | 2015 |
Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats.
Topics: Acute Lung Injury; Animals; Contusions; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Oxidative Stress; Phosphorylcholine; Protective Agents; Rats; Rats, Wistar; Sphingosine; Treatment Outcome | 2015 |
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; beta-Cyclodextrins; Carrier Proteins; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Membrane Microdomains; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 8; Myocytes, Cardiac; Phosphoproteins; Phosphorylcholine; Primary Cell Culture; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases | 2015 |
Sphingolipids inhibit vimentin-dependent cell migration.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Movement; Fibroblasts; Humans; Lysophospholipids; Mice; Phosphorylation; Phosphorylcholine; Receptors, Lysosphingolipid; rho-Associated Kinases; Signal Transduction; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptors; Vimentin | 2015 |
Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Cholesterol; Glycerylphosphorylcholine; Lipid Bilayers; Microscopy, Fluorescence; Models, Molecular; Phosphatidylcholines; Phosphorylcholine; Sphingosine | 2015 |
Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients.
Topics: Biomarkers; Female; Humans; Inflammation; Lipids; Lysophospholipids; Male; Metabolic Syndrome; Middle Aged; Obesity; Phosphorylcholine; Risk Factors; Sphingosine; Tetraspanin 30 | 2015 |
Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line.
Topics: Antineoplastic Agents; Biological Products; Cell Survival; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; HCT116 Cells; Humans; Lactones; Lysophosphatidylcholines; Lysophospholipids; Metabolic Networks and Pathways; Metabolomics; Phosphatidylcholines; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry | 2016 |
Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12.
Topics: Cell Line; Cell Movement; Fingolimod Hydrochloride; Humans; Keratin-8; Organophosphates; Phosphorylation; Phosphorylcholine; Protein Phosphatase 2; Receptors, G-Protein-Coupled; RNA, Small Interfering; Sphingosine | 2016 |
Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Keratin-8; Lung Neoplasms; Membrane Glycoproteins; Microscopy, Confocal; Molecular Chaperones; Phosphorylation; Phosphorylcholine; Protein Binding; Protein Phosphatase 2; RNA Interference; Sphingosine; Ubiquitination | 2016 |
Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways.
Topics: Animals; Antigens, Ly; beta Catenin; Biomarkers; Cell Differentiation; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; JNK Mitogen-Activated Protein Kinases; Membrane Microdomains; Membrane Proteins; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylcholine; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Stem Cells; Time Factors | 2016 |
Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.
Topics: Breast Neoplasms; Caproates; Cell Line, Tumor; Female; Flavonoids; Gene Silencing; Humans; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Phosphorylcholine; Polycyclic Compounds; Sphingosine; Valine; Wnt Signaling Pathway | 2016 |
Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Contrast Media; Creatinine; Humans; Injections, Intraperitoneal; Kidney; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phosphorylcholine; Rats; Rats, Wistar; Sphingosine; Superoxide Dismutase | 2016 |
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells.
Topics: Animals; Cell Adhesion; Cells, Cultured; Coculture Techniques; Macrophages; Male; Membrane Microdomains; Muscle, Smooth, Vascular; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sphingosine; Tumor Necrosis Factor-alpha | 2016 |
Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival.
Topics: Adipose Tissue; Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cryopreservation; Endothelial Progenitor Cells; Graft Survival; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylcholine; Sphingosine | 2016 |
Omega-3 and omega-6 DPA equally inhibit the sphingosylphosphorylcholine-induced Ca
Topics: Calcium; Cell Membrane; Cells, Cultured; Coronary Vessels; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylation; Phosphorylcholine; Protein Transport; rho-Associated Kinases; Sphingosine | 2017 |
Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
Topics: Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Keratins; Lung Neoplasms; Neoplasm Staging; Phosphorylation; Phosphorylcholine; Prognosis; Proto-Oncogene Proteins c-akt; ras Proteins; Sphingosine; Survival Rate; Tumor Cells, Cultured | 2017 |
Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases.
Topics: Biomarkers; Case-Control Studies; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Niemann-Pick Disease, Type A; Niemann-Pick Disease, Type B; Niemann-Pick Disease, Type C; Phosphorylcholine; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Tandem Mass Spectrometry | 2017 |
DJ-1 Regulates Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle-like Cells in Response to Sphingosylphosphorylcholine.
Topics: Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Oxidation-Reduction; Phosphorylcholine; Protein Deglycase DJ-1; Proteome; Reactive Oxygen Species; Sphingosine | 2017 |
Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca
Topics: Animals; Antiprotozoal Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membrane; Homeostasis; Leishmania donovani; Membrane Potential, Mitochondrial; Nifedipine; Organelles; Phosphorylcholine; Sphingosine | 2018 |
A Novel Regulatory Mechanism for Differentiation of Mesenchymal Stem Cell: Redox State of DJ-1 Matters.
Topics: Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Muscle, Smooth; Myocytes, Smooth Muscle; Oxidation-Reduction; Phosphorylcholine; Reactive Oxygen Species; Sphingosine | 2018 |
Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome.
Topics: Animals; Blood Platelets; Humans; Lipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylcholine; Platelet Activation; Sphingomyelin Phosphodiesterase; Sphingosine; Thrombosis | 2018 |
Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry.
Topics: Aldehydes; Amines; Biomimetic Materials; Biomimetics; Imines; Liposomes; Phospholipids; Phosphorylcholine; Sphingosine | 2018 |
Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling.
Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine | 2019 |
Complete Myogenic Differentiation of Adipogenic Stem Cells Requires Both Biochemical and Mechanical Stimulation.
Topics: Adipogenesis; Adult; Aged; Bioreactors; Bone Morphogenetic Protein 4; Cell Differentiation; Collagen Type I; Female; Fibrin; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Myocytes, Smooth Muscle; Phosphorylcholine; Physical Stimulation; Pressure; Sphingosine; Stress, Mechanical; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta; Tunica Media | 2020 |
Alterations in phospholipid profiles of erythrocytes deep-frozen without cryoprotectants.
Topics: Blood Preservation; Cryopreservation; Erythrocyte Membrane; Erythrocytes; Humans; Phospholipids; Phosphorylcholine; Sphingosine | 2019 |
Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549 cells in a synergistic manner.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Synergism; Humans; Lysophospholipids; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Sphingosine | 2019 |
Development of a Diagnostic Screening Strategy for Niemann-Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine.
Topics: Chromatography, Liquid; Humans; Niemann-Pick Diseases; Phosphatidylcholines; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry | 2020 |
A combination of 7-ketocholesterol, lysosphingomyelin and bile acid-408 to diagnose Niemann-Pick disease type C using LC-MS/MS.
Topics: Bile Acids and Salts; Biomarkers; Chromatography, Liquid; Humans; Infant, Newborn; Ketocholesterols; Niemann-Pick Disease, Type C; Phosphorylcholine; Sphingosine; Tandem Mass Spectrometry | 2020 |
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway.
Topics: Animals; Apoptosis; Calmodulin; Cell Hypoxia; Fibrosis; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Rats, Wistar; Sphingosine; STAT3 Transcription Factor | 2020 |
Identification of a Reliable Biomarker Profile for the Diagnosis of Gaucher Disease Type 1 Patients Using a Mass Spectrometry-Based Metabolomic Approach.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Early Diagnosis; Female; Gaucher Disease; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Phosphorylcholine; Prognosis; Psychosine; Sensitivity and Specificity; Sphingosine; Young Adult | 2020 |
MicroRNA-155-5p/EPAS1/interleukin 6 pathway participated in the protection function of sphingosylphosphorylcholine to ischemic cardiomyocytes.
Topics: Animals; Apoptosis; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Cardiotonic Agents; Cell Hypoxia; Cell Nucleus; Down-Regulation; Fibroblast Growth Factor 2; HEK293 Cells; Humans; Interleukin-6; MicroRNAs; Models, Biological; Myocardial Ischemia; Myocytes, Cardiac; Phosphorylation; Phosphorylcholine; Rats, Wistar; RNA, Messenger; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2021 |
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca
Topics: Animals; Blotting, Western; Bone Resorption; Calcium; Calmodulin; Cell Survival; Female; Mice; Mice, Inbred C57BL; Osteoclasts; Osteoporosis; Ovariectomy; Phosphorylcholine; Real-Time Polymerase Chain Reaction; Sphingosine; X-Ray Microtomography | 2021 |
A Novel Function of Sphingosylphosphorylcholine on the Inhibitory Effects of Acetylcholinesterase Activity.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Neostigmine; Phosphorylcholine; Rivastigmine; Sphingosine | 2021 |
Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway.
Topics: Animals; Calcium; Hesperidin; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Swine | 2022 |
Sphingosylphosphorylcholine ameliorates experimental sjögren's syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells.
Topics: Animals; B-Lymphocytes, Regulatory; Disease Models, Animal; Female; Humans; Inflammation; Mice; Mice, Inbred NOD; Phosphorylcholine; Sialadenitis; Sjogren's Syndrome; Sphingosine | 2022 |
Sphingosylphosphorylcholine ameliorates doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by reducing excessive mitophagy and mitochondrial dysfunction.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cardiotoxicity; Doxorubicin; Mitochondria; Mitophagy; Myocytes, Cardiac; Phosphorylcholine; Sphingosine; Ubiquitin-Protein Ligases; Zebrafish | 2022 |
Landscape of circulating metabolic fingerprinting for keloid.
Topics: Humans; Keloid; Logistic Models; Palmitoylcarnitine; Phosphorylcholine; Sphingosine | 2022 |