Compounds > phosphorylcholine

phosphorylcholine and edelfosine

phosphorylcholine has been researched along with edelfosine in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.28)18.7374
1990's23 (37.70)18.2507
2000's23 (37.70)29.6817
2010's11 (18.03)24.3611
2020's2 (3.28)2.80

Authors

AuthorsStudies
Eibl, H; Kötting, J; Marschner, NW; Neumüller, W; Unger, C1
Fleer, EA; Kaufmann-Kolle, P1
Eibl, H; Kötting, J; Marschner, NW; Unger, C1
Eibl, H; Kötting, J; Marschner, N; Unger, C1
Berkovic, D; Doenecke, D; Eibl, H; Hochhuth, C; Unger, C1
Eibl, H; Fleer, EA; Kuo, JF; Raynor, RL; Shoji, M; Vogler, WR1
Bauer, S; Remmele, T; Stricker, H; Sturm, V; Wowra, B; Zeller, WJ1
Eibl, H; Kim, DJ; Nagel, GA; Unger, C; Vehmeyer, K1
Berger, MR; Scherf, HR; Schmähl, D; Schuler, B1
Boggs, KP; Jackowski, S; Yang, W1
Geilen, CC; Haase, A; Orfanos, CE; Wieder, T1
Bruyneel, EA; Mareel, MM; Steelant, WF; Van den Eeckhout, EG1
Berkovic, D; Berkovic, K; Eibl, H; Fleer, EA; Unger, C1
Berkovic, D; Fleer, EA; Grunwald, U; Hiddemann, W1
Croft, SL; Snowdon, D; Yardley, V1
van Heugten, HG; Verdonck, LF1
Lundberg, BB1
Boggs, K; Jackowski, S; Rock, CO1
Berkovic, D; Fleer, EA; Hiddemann, W; Kuduz, J1
Arthur, G; Bittman, R1
Civoli, F; Daniel, LW1
Berkovic, D1
Grosman, N2
Bartelink, H; Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF2
de Castro, SL; Meirelles, MN; Santa-Rita, RM; Santos Barbosa, H1
Hart, D; Heise, N; Klenner, T; Lux, H; Opperdoes, FR1
Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF1
Castanys, S; Gamarro, F; Jiménez, IA; Parodi-Talice, A; Pérez-Victoria, FJ; Pérez-Victoria, JM; Ravelo, AG1
Croft, SL; Escobar, P; Marques, C; Matu, S1
Fisher, MC; Mar, MH; Sadler, TW; Zeisel, SH1
Croft, SL; Duchêne, M; Seifert, K1
Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW1
Castanys, S; Gamarro, F; Ouellette, M; Pérez-Victoria, FJ1
Barbosa, HS; de Castro, SL; Henriques-Pons, A; Santa-Rita, RM1
Azzouz, S; Garcia, RG; Maache, M; Osuna, A1
Henriquez, FL; Ingram, PR; McBride, J; Roberts, CW1
Barbosa, HS; de Castro, SL; Lira, R; Santa-Rita, RM; Urbina, JA1
Gajate, C; Mollinedo, F1
Azzouz, S; Dos Santos, MF; Maache, M; Osuna, A; Petavy, AF; Sarciron, ME1
Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T1
Klarenbeek, JB; Perrissoud, D; Solary, E; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR1
Klarenbeek, JB; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR1
Bartelink, H; Budde, M; de Jong, D; Koolwijk, P; Peters, E; Ruiter, GA; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR; Zerp, SF1
Azzouz, S; Maache, M; Osuna, A; Petavy, AF; Sánchez-Moreno, M1
Alzate, JF; Arias, A; de la Iglesia-Vicente, J; Jiménez-Ruiz, A; Mollinedo, F; Rico, E1
Cabrera-Serra, MG; Piñero, JE; Valladares, B1
Carrasco, MP; Jiménez-López, JM; Marco, C; Ríos-Marco, P; Segovia, JL1
Chae, S; Kim, B; Kim, DH; Kim, Y; Lucas, A; Rivera-Pabon, O1
Baquedano, Y; Font, M; Jiménez-Ruiz, A; Moreno-Mateos, D; Palop, JA; Plano, D; Sanmartín, C1
van Blitterswijk, WJ; Verheij, M1
Burgeiro, A; Carvalho, FS; Mollinedo, F; Oliveira, PJ; Pereira, CV; Pereira, GC1
Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H1
Acuña, AU; Castro, BM; Delgado, J; Fedorov, A; Hornillos, V; Mollinedo, F; Prieto, M1
Dakir, EL; Dakir, el H; López-Abán, J; Mollinedo, F; Muro, A; Varela-M, RE; Yepes, E1
Cabello, J; Mohler, WA; Mollinedo, F; Reis-Sobreiro, M; Rodríguez-Matellán, AG; Sáenz-Narciso, B; Sánchez-Blanco, A1
Gajate, C; Legarda-Ceballos, AL; López-Abán, J; Mollinedo, F; Muro, A; Rojas-Caraballo, J; Ruano, AL; Yepes, E1
Chen, M; Iovanna, JL; Lan, W; Liu, X; Luo, B; Peng, L; Xia, Y; Zhou, Z1
Aslanidis, C; Buechler, C1
Dahlström, M; Hamakubo, T; Hamano, F; Ishii, S; Kobayashi, D; Masuda, K; Sato, N; Shimizu, T; Yasuda, D1

Reviews

6 review(s) available for phosphorylcholine and edelfosine

ArticleYear
The inhibition of cell signaling pathways by antitumor ether lipids.
    Biochimica et biophysica acta, 1998, Feb-05, Volume: 1390, Issue:1

    Topics: Animals; Antineoplastic Agents; Calcium; Furans; Humans; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Receptors, Cell Surface; Signal Transduction

1998
Cytotoxic etherphospholipid analogues.
    General pharmacology, 1998, Volume: 31, Issue:4

    Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; In Vitro Techniques; Phospholipid Ethers; Phosphorylcholine

1998
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
    International journal of radiation oncology, biology, physics, 2001, Feb-01, Volume: 49, Issue:2

    Topics: Antineoplastic Agents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Signal Transduction

2001
Antiprotozoal activities of phospholipid analogues.
    Molecular and biochemical parasitology, 2003, Volume: 126, Issue:2

    Topics: Animals; Antiprotozoal Agents; Leishmania; Parasitic Sensitivity Tests; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Structure-Activity Relationship; Trypanosoma

2003
Anticancer mechanisms and clinical application of alkylphospholipids.
    Biochimica et biophysica acta, 2013, Volume: 1831, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; Organophosphates; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Quaternary Ammonium Compounds; Signal Transduction

2013
Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Diagnosis, Differential; Disease Models, Animal; Disease Progression; Humans; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; Liver Neoplasms; Oxidative Stress; Phospholipid Ethers; Phosphorylcholine; Plasmalogens; Severity of Illness Index

2020

Other Studies

55 other study(ies) available for phosphorylcholine and edelfosine

ArticleYear
Hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine: a comparison of hemolytic activity, serum binding and tissue distribution.
    Progress in experimental tumor research, 1992, Volume: 34

    Topics: Animals; Antineoplastic Agents; Female; Hemolysis; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Tissue Distribution

1992
Morphological changes of adherent and nonadherent cells by treatment with hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine observed by scanning electron microscopy.
    Progress in experimental tumor research, 1992, Volume: 34

    Topics: Antineoplastic Agents; Cell Adhesion; Humans; Microscopy, Electron, Scanning; Phospholipid Ethers; Phosphorylcholine; Tumor Cells, Cultured

1992
Determination of alkylphosphocholines and of alkyl-glycero-phosphocholines in biological fluids and tissues.
    Progress in experimental tumor research, 1992, Volume: 34

    Topics: Animals; Antineoplastic Agents; Body Fluids; Female; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Viscera

1992
Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment.
    Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Densitometry; Drug Administration Schedule; Female; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution

1992
Effects of antineoplastic phospholipids on parameters of cell differentiation in U937 cells.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:5

    Topics: Antigens, Surface; Antineoplastic Agents; Blotting, Northern; Cell Transformation, Neoplastic; DNA Probes; Fatty Alcohols; Gene Expression Regulation, Neoplastic; Histones; Leukemia, Promyelocytic, Acute; Lysophosphatidylcholines; Phorbol Esters; Phospholipid Ethers; Phospholipids; Phosphorylcholine; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate

1990
Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells.
    Lipids, 1991, Volume: 26, Issue:2

    Topics: Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Phospholipid Ethers; Phosphoproteins; Phosphorylation; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate

1991
Interstitial chemotherapy of experimental gliomas.
    Cancer treatment reviews, 1990, Volume: 17, Issue:2-3

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Glioma; Humans; Injections, Intralesional; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Phospholipid Ethers; Phosphorylcholine; Polyesters; Rats; Rats, Inbred Strains

1990
Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:1

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Female; Hematopoietic Stem Cells; Leukocyte Count; Lysophosphatidylcholines; Mice; Phospholipid Ethers; Phosphorylcholine

1989
Therapeutic activity of ET-18-OCH3 and hexadecylphosphocholine against mammary tumors in BD-VI rats.
    Lipids, 1987, Volume: 22, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Choline; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Male; Mammary Neoplasms, Experimental; Phospholipid Ethers; Phosphorylcholine; Rats

1987
The association of lipid activators with the amphipathic helical domain of CTP:phosphocholine cytidylyltransferase accelerates catalysis by increasing the affinity of the enzyme for CTP.
    The Journal of biological chemistry, 1995, Oct-13, Volume: 270, Issue:41

    Topics: Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Catalysis; Cell Line; Chlorocebus aethiops; Choline-Phosphate Cytidylyltransferase; Cytidine Triphosphate; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Kinetics; Molecular Sequence Data; Mutagenesis; Nucleotidyltransferases; Phospholipid Ethers; Phosphorylcholine; Polymerase Chain Reaction; Protein Structure, Secondary; Rats; Recombinant Proteins; Sequence Deletion; Spodoptera; Transfection

1995
The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
    Lipids, 1995, Volume: 30, Issue:5

    Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Cell Division; Cell Line; Choline-Phosphate Cytidylyltransferase; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine

1995
Capillary gas chromatography of hexadecylphosphocholine in Caco-2T cells and cell culture media.
    Analytical biochemistry, 1995, May-01, Volume: 227, Issue:1

    Topics: Antineoplastic Agents; Cell Death; Chromatography, Gas; Chromatography, Ion Exchange; Culture Media; Dose-Response Relationship, Drug; Humans; Phospholipid Ethers; Phosphorylcholine; Trimethylsilyl Compounds; Tumor Cells, Cultured

1995
Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:4

    Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Humans; Leukemia; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1994
Induction of resistance to hexadecylphosphocholine in the highly sensitive human epidermoid tumour cell line KB.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:3

    Topics: Antineoplastic Agents; Choline; Drug Resistance, Neoplasm; Humans; Inositol; KB Cells; Phospholipid Ethers; Phosphorylcholine

1996
The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:6

    Topics: Animals; Antineoplastic Agents; Chagas Disease; Cricetinae; Female; Furans; Leishmania donovani; Leishmaniasis, Visceral; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African

1996
Ether lipids are effective cytotoxic drugs against multidrug-resistant acute leukemia cells and can act by the induction of apoptosis.
    Leukemia research, 1997, Volume: 21, Issue:1

    Topics: Adult; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Phospholipid Ethers; Phosphorylcholine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Stem Cell Assay

1997
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture.
    Anti-cancer drug design, 1997, Volume: 12, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Drug Antagonism; Drug Synergism; Hemolysis; HL-60 Cells; Humans; Jurkat Cells; Liposomes; Paclitaxel; Phospholipid Ethers; Phosphorylcholine; Teniposide

1997
The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.
    Biochimica et biophysica acta, 1998, Jan-05, Volume: 1389, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Recombinant Proteins

1998
Expression of two 50 kDa proteins is associated with sensitivity towards etherlipid analogues in the human leukaemia cell line HL 60.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:11

    Topics: Antineoplastic Agents; Cell Differentiation; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Neoplasm Proteins; Phospholipid Ethers; Phosphorylcholine

1997
Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4

    Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Survival; Culture Media, Serum-Free; Drug Resistance; Enzyme Activation; Furans; HL-60 Cells; Humans; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tetradecanoylphorbol Acetate

1998
Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
    Immunopharmacology, 1998, Volume: 40, Issue:2

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Enzyme Inhibitors; Gallic Acid; Imidazoles; Leukocytes; Male; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Staurosporine; Synaptosomes

1998
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Endothelium, Vascular; Gamma Rays; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Signal Transduction; U937 Cells

1999
Effect of the anti-neoplastic agents edelfosine (ET-18-OCH3), ilmofosine (BM 41.440) and the hexadecylphosphocholine analogues D-20133 and D-21266 on histamine release from isolated rat mast cells.
    Immunopharmacology, 1999, Volume: 44, Issue:3

    Topics: Animals; Antineoplastic Agents; Calcimycin; Histamine Release; Ionophores; Male; Mast Cells; Phorbol Esters; Phospholipid Ethers; Phosphorylcholine; Piperidines; Rats; Rats, Wistar

1999
Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi.
    Acta tropica, 2000, Mar-25, Volume: 75, Issue:2

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Life Cycle Stages; Lysophospholipids; Macrophages; Mice; Microscopy, Electron; Phospholipid Ethers; Phosphorylcholine; Temperature; Time Factors; Trypanosoma cruzi

2000
Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.
    Molecular and biochemical parasitology, 2000, Volume: 111, Issue:1

    Topics: Acylation; Acyltransferases; Alcohol Oxidoreductases; Alkyl and Aryl Transferases; Animals; Antiprotozoal Agents; Leishmania mexicana; Microbodies; Phospholipid Ethers; Phosphorylcholine

2000
Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Daunorubicin; Drug Resistance, Multiple; Fluorescence; Humans; Leishmania tropica; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine

2001
Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B.
    Acta tropica, 2002, Volume: 81, Issue:2

    Topics: Amphotericin B; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania; Macrophages, Peritoneal; Mice; Phospholipid Ethers; Phosphorylcholine; Species Specificity

2002
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:6

    Topics: Acetylcholine; Animals; Betaine; Cells, Cultured; Central Nervous System; Ceramides; Choline; Deanol; Diglycerides; Embryo, Mammalian; Embryonic and Fetal Development; Gastrula; Mice; Models, Neurological; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Sphingomyelins

2002
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.
    Anti-cancer drugs, 2003, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Growth Inhibitors; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction

2003
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
    The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38

    Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Dose-Response Relationship, Drug; Drug Resistance; Drug Resistance, Multiple; Endocytosis; Gene Deletion; Ketoconazole; Leishmaniasis; Lipid Metabolism; Lysophosphatidylcholines; Membrane Transport Proteins; Microscopy, Fluorescence; Mutation; Nuclear Envelope; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Point Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors

2003
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.
    The Journal of biological chemistry, 2003, Dec-12, Volume: 278, Issue:50

    Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Animals; Antiprotozoal Agents; Biological Transport; Blotting, Southern; Carrier Proteins; Cell Membrane; Chromosome Mapping; Cloning, Molecular; Cosmids; Dose-Response Relationship, Drug; Drug Resistance; Genotype; Immunoblotting; Leishmania donovani; Membrane Proteins; Membrane Transport Proteins; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Phenotype; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipid Transfer Proteins; Phosphorylcholine; Plasmids; Point Mutation; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection

2003
Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:4

    Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Inhibitory Concentration 50; Leishmania; Lysophospholipids; Macrophages, Peritoneal; Mice; Microscopy, Electron; Phospholipid Ethers; Phosphorylcholine

2004
Leishmanicidal activity of edelfosine, miltefosine and ilmofosine.
    Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:1

    Topics: Animals; Antiprotozoal Agents; Cell Line; DNA, Protozoan; Flow Cytometry; Leishmania donovani; Mice; Phospholipid Ethers; Phosphorylcholine; Protozoan Proteins; RNA, Protozoan

2005
Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba.
    Journal of clinical microbiology, 2005, Volume: 43, Issue:2

    Topics: Acanthamoeba; Acanthamoeba castellanii; Amebicides; Animals; Chlorhexidine; Colony Count, Microbial; Colorimetry; Culture Media; Indicators and Reagents; Oxazines; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Xanthenes

2005
Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:5

    Topics: Animals; Chlorocebus aethiops; Drug Synergism; Drug Therapy, Combination; Ergosterol; Ketoconazole; Lysophospholipids; Microscopy, Electron; Microscopy, Electron, Scanning; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2005
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
    Blood, 2007, Jan-15, Volume: 109, Issue:2

    Topics: Apoptosis; Caspase 8; Cell Line, Tumor; Cell Proliferation; fas Receptor; Fas-Associated Death Domain Protein; Humans; Membrane Microdomains; Multiple Myeloma; Phospholipid Ethers; Phosphorylcholine; Signal Transduction; Structure-Activity Relationship

2007
Aspects of the cytological activity of edelfosine, miltefosine, and ilmofosine in Leishmania donovani.
    The Journal of parasitology, 2006, Volume: 92, Issue:5

    Topics: Animals; Antiprotozoal Agents; Apoptosis; Cell Cycle; Cell Line; Cricetinae; Female; Humans; Hydrogen-Ion Concentration; Leishmania donovani; Macrophages; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine

2006
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
    Molecular microbiology, 2007, Volume: 64, Issue:5

    Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic

2007
A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:8

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endocytosis; HeLa Cells; Humans; Lymphoma; Membrane Microdomains; Mice; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Sphingomyelins; Time Factors

2007
Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
    Biochemical pharmacology, 2007, Nov-15, Volume: 74, Issue:10

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; KB Cells; Lymphoma; Membrane Microdomains; Mice; Phospholipid Ethers; Phospholipids; Phosphorylcholine

2007
Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.
    Anti-cancer drugs, 2008, Volume: 19, Issue:1

    Topics: Alkylation; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Capillaries; Cattle; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Indicators and Reagents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine

2008
Effect of alkyl-lysophospholipids on some aspects of the metabolism of Leishmania donovani.
    The Journal of parasitology, 2007, Volume: 93, Issue:5

    Topics: Animals; Carbohydrate Metabolism; Humans; Leishmania donovani; Magnetic Resonance Spectroscopy; Parasitic Sensitivity Tests; Phospholipid Ethers; Phosphorylcholine; Protozoan Proteins; Superoxide Dismutase; Type C Phospholipases

2007
Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Animals; Antiprotozoal Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Leishmania infantum; Membrane Potential, Mitochondrial; Phospholipid Ethers; Phosphorylcholine; Recombinant Proteins; Transfection

2008
In vivo activity of perifosine against Leishmania amazonensis.
    Acta tropica, 2008, Volume: 108, Issue:1

    Topics: Administration, Oral; Animals; Antiprotozoal Agents; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine; Survival Analysis

2008
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
    British journal of pharmacology, 2010, Volume: 160, Issue:2

    Topics: Antineoplastic Agents; Biological Transport; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Cholesterol; Drug Delivery Systems; Endoplasmic Reticulum; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Liver Neoplasms; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine; Reverse Transcriptase Polymerase Chain Reaction

2010
Targeting the PI3K/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds.
    PloS one, 2010, Sep-30, Volume: 5, Issue:9

    Topics: Anti-HIV Agents; Cell Death; Cell Line; Cells, Cultured; HIV Infections; HIV-1; Humans; Macrophages; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction

2010
Selenocyanates and diselenides: a new class of potent antileishmanial agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

    Topics: Aminophenols; Animals; Antiprotozoal Agents; Cell Line, Tumor; Cyanates; Humans; Inhibitory Concentration 50; Leishmania infantum; Leishmaniasis, Visceral; Life Cycle Stages; Monocytes; Neoplasms; Phospholipid Ethers; Phosphorylcholine; Selenium Compounds; Structure-Activity Relationship

2011
Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.
    Mitochondrion, 2013, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Oxidative Phosphorylation; Permeability; Phospholipid Ethers; Phosphorylcholine; Rats, Wistar

2013
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Neoplasms; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt

2013
Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids.
    The journal of physical chemistry. B, 2013, Jul-03, Volume: 117, Issue:26

    Topics: Antineoplastic Agents; Humans; Jurkat Cells; Liposomes; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine

2013
In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Animals; Antineoplastic Agents; Antiparasitic Agents; Apoptosis; Female; Mice; Phospholipid Ethers; Phosphorylcholine; Schistosoma mansoni; Schistosomiasis mansoni

2014
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:21

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Cholesterol; Drug Resistance; Embryo, Nonmammalian; Embryonic Development; Humans; Insulin-Like Growth Factor I; Larva; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine

2014
The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.
    Acta tropica, 2016, Volume: 162

    Topics: Animals; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Female; Larva; Mice; Phospholipid Ethers; Phosphorylcholine; Strongyloides; Strongyloidiasis

2016
Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation.
    Chemical communications (Cambridge, England), 2019, Aug-07, Volume: 55, Issue:61

    Topics: Anti-Obesity Agents; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lipid Droplets; Liver X Receptors; Phospholipid Ethers; Phosphorylcholine; Poly(ADP-ribose) Polymerases; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Quercetin; Signal Transduction

2019
Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR82.
    European journal of pharmacology, 2023, Sep-05, Volume: 954

    Topics: Animals; Drug Inverse Agonism; Ligands; Lysophosphatidylcholines; Lysophospholipids; Mice; Phosphorylcholine

2023