phosphorylcholine has been researched along with choline in 647 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 424 (65.53) | 18.7374 |
| 1990's | 113 (17.47) | 18.2507 |
| 2000's | 57 (8.81) | 29.6817 |
| 2010's | 40 (6.18) | 24.3611 |
| 2020's | 13 (2.01) | 2.80 |
| Authors | Studies |
|---|---|
| Jaton, JC; Riesen, WF; Schlessinger, J | 1 |
| Cosenza, H; Quintáns, J | 1 |
| Bean, B; Tomasz, A | 1 |
| Farrell, PM; Stephenson, LL; Ulane, RE | 1 |
| Cheney, DL; Costa, E | 1 |
| Braciale, V; Davie, JM; Der Balian, G | 1 |
| Goetze, AM; Richards, JH | 3 |
| Glaudemans, CP; Manjula, BN | 1 |
| Williams, RE; Young, NM | 1 |
| Hoebeke, J; Strosberg, AD; Vray, B; Zeeuws, R | 1 |
| Cohen, GH; Davies, DR; Padlan, EA; Potter, M; Rudikoff, S; Segal, DM | 1 |
| Luffau, G; Pery, P; Petit, A; Poulain, J | 2 |
| Köhler, H | 1 |
| Riblet, R; Trenkner, E | 1 |
| Grossberg, AL; Krausz, LM; Pressman, D | 2 |
| Kluskens, L; Köhler, H; Lee, W | 1 |
| Fiedel, BA; Gewurz, H; Osmand, AP | 1 |
| Augustin, A; Cosenza, H | 1 |
| Claflin, JL; Rudikoff, S | 2 |
| Claflin, JL | 3 |
| Gearhart, PJ; Klinman, NR; Sigal, NH | 1 |
| Kleijer, WJ; Niermeijer, MF; Patrick, AD; Young, E | 1 |
| Augustin, AA; Cosenza, H; Julius, MH | 3 |
| Paul, BD; Seligman, AM; Serrano, AA; Serrano, JA; Wasserkrug, HL | 1 |
| Köhler, H; Richardson, RC; Smyk, S | 1 |
| Accolla, RS; Cancro, MP; Gearhart, PJ; Klinman, NR; Sigal, NH | 1 |
| Kim, BS; Mallat, L; Rowley, DA | 1 |
| Alpert, R; Currie, JR; Grafstein, B; Whitnall, MH | 1 |
| Bennett, LG; Glaudemans, CP | 2 |
| Hanin, I; Shih, TM | 1 |
| Potter, M; Rudikoff, S | 2 |
| Riesen, WF | 1 |
| Cheney, DL; Costa, E; Racagni, G; Trabucchi, M | 1 |
| Guynn, RW | 1 |
| Mookerjea, S | 1 |
| Den Tandt, WR; Eggermont, E; Jaeken, J; Leroy, JG | 1 |
| Höltje, JV; Tomasz, A | 1 |
| Brady, RO; Gal, AE; Hibbert, SR; Pentchev, PG | 1 |
| Inman, JK; Lieberman, R; Mond, JJ; Mosier, DE; Paul, WE | 1 |
| Gearhart, PJ; Klinman, NR; Metcalf, ES; Pickard, AR; Sigal, NH | 1 |
| Kaplan, DR; Köhler, H; Quintans, J | 1 |
| Behmer, OA; Ferrarini, E; Fujimura, I; Fujimura, MD; Lemos, PC; Penteado, S; Tolosa, EM | 1 |
| Bottomly, K; Mathieson, BJ; Mosier, DE | 1 |
| Kaplan, RB; Quintáns, J | 2 |
| Godfrey, G | 1 |
| Davie, JM; Schroer, J | 1 |
| Gutman, GA; Mitchell, GF | 1 |
| McKearn, JP; Miller, GW; Quintáns, J | 1 |
| Köhler, H; Miller, GW | 1 |
| Honegger, JL; Isakson, PC; Kinsky, SC | 2 |
| Kishimoto, T; Shigemoto, S; Watanabe, T; Yamamura, Y | 1 |
| Alving, BM; Alving, CR; Neidig, M; Schuster, BG | 1 |
| Barak, AJ; Tuma, DJ | 2 |
| Cheney, DL; Wood, PL | 1 |
| Prince, AK; Wong, PT | 1 |
| Fowlkes, BJ; Hooghe, RJ; Hooghe-Peters, EL | 1 |
| Baldo, BA; Fletcher, TC; Krilis, S | 1 |
| Blaser, K; de Weck, AL; Geiser, M | 1 |
| Arienti, G; Corazzi, L; Mezzasoma, I; Orlando, P; Porcellati, G; Tirillini, B | 1 |
| Baldo, BA; Fletcher, TC; Uhlenbeuck, G | 1 |
| Arienti, G; Corazzi, L; Massari, P; Orlando, P; Porcellati, G; Saracino, P | 1 |
| Galeone, F; Marescotti, V; Saba, P; Salvadorini, F | 1 |
| Choy, PC; Vance, DE; Whitehead, FW | 1 |
| Goz, B; Wharton, W | 1 |
| Claflin, JL; Cubberley, M | 2 |
| Kaplan, DR; Quintáns, J | 1 |
| Arrata, WS; Burt, T; Corder, S | 1 |
| Gardemin, H; Kuck, U; Niedieck, B | 1 |
| Millington, WR; Zeisel, SH | 1 |
| Caputi, AP; Marmo, E; Ottavo, R; Rossi, F; Sasso, M; Somma, A; Vacca, C | 1 |
| Grossberg, AL; Nutt, NB; Pressman, D | 1 |
| Lewers, HM; Mitchell, GF | 1 |
| Oriol, R; Potter, M; Riesen, W; Rudikoff, S | 1 |
| Badin, J; Canal, J; Delattre, J; Girard, ML | 1 |
| Kato, Y; Kobayashi, T; Kuhara, K; Ogiso, T | 1 |
| Braun, DG; Jaton, JC; Riesen, WF | 1 |
| Jaton, JC; Riesen, WF | 1 |
| Davies, DR; Padlan, EA; Potter, M; Rudikoff, S | 1 |
| Bygrave, FL; Dawson, RM | 1 |
| Cheney, DL; Costa, E; Racagni, G; Zsilla, G | 1 |
| Fash, FJ; Gal, AE | 1 |
| Kato, Y; Kobayashi, T; Kuhara, K; Masuda, H; Ogiso, T | 1 |
| Kuksis, A; O'Doherty, PJ; Smith, NB | 1 |
| Bach, BA; Gewurz, H; Osmand, AP | 1 |
| Asoklis, K; Asoklis, R | 1 |
| Paul, BD; Serrano, AA; Serrano, JA; Wasserkrug, HL | 1 |
| McDonald, DF; Schofield, BH | 1 |
| Köhler, H; Richardson, BC; Rowley, DA; Smyk, S | 1 |
| Pedata, F; Pepeu, G; Wieraszko, A | 1 |
| Kohler, H; Strayer, DS | 1 |
| Kato, Y; Kuhara, K; Noda, N; Ogiso, T | 1 |
| Seligman, AM; Serrano, AA; Serrano, JA; Shannon, WA; Sternberger, NJ; Wasserkrug, HL | 1 |
| Hildebrand, CE; London, RE; Matwiyoff, NA; Olson, ES | 1 |
| Collins, FD; Shamgar, FA | 1 |
| Kewitz, H; Pleul, O | 1 |
| Cosenza, H | 1 |
| Cosenza, H; Lefkovits, I; Quintáns, J | 1 |
| Davies, DR; Labaw, LW; Padlan, EA; Segal, DM | 1 |
| Yaksh, TL; Yamamura, HI | 1 |
| Krawiec, L; Najle, R; Pasquini, JM; Soto, EF | 1 |
| Kucherenko, NE; Vasil'ev, AN | 1 |
| Brown, AR; Crandall, CA | 1 |
| Blusztajn, JK; Growdon, JH; Nitsch, RM; Pittas, AG; Slack, BE; Wurtman, RJ | 1 |
| Geilen, CC; Reutter, W; Wieder, T | 2 |
| Guild, SB; Muir, TC; Nally, JE | 1 |
| McKenzie, FR; Pouysségur, J; Seuwen, K | 1 |
| Chan, M; Choy, PC; Hatch, G; Man, RY | 1 |
| Dolezal, V; Tucek, S | 1 |
| Mattila, P; Renkonen, R | 1 |
| Degani, H; Ronen, SM; Rushkin, E | 2 |
| Bore, P; Brereton, IM; Crozier, S; Doddrell, DM; Galloway, GJ; Moxon, LN; Rose, SE | 1 |
| Desouky, MA; Geller, AM; Jernigan, HM | 1 |
| Arevalo, JI; Saz, HJ | 1 |
| Lazdunski, A; Shortridge, VD; Vasil, ML | 1 |
| Gu, H; LaBelle, EF; Trajkovic, S | 1 |
| Conti, F; Delfini, M; Miccheli, A; Piccolella, E; Ricciolini, R | 1 |
| Hentschel, D; Huk, W; Ladebeck, R; Neundörfer, B; Schuierer, G; Schüler, P; Stefan, H; Wittig, R | 1 |
| Brown, LR; Martenson, RE; Mendz, GL | 1 |
| Domenech, CE; Lisa, TA; Lucchini, AE | 1 |
| Denkers, EY; Hayes, CE; Wassom, DL | 1 |
| Fain, JN; Pittner, RA | 1 |
| Klein, J; Köppen, A; Löffelholz, K; Schmitthenner, J | 1 |
| Buyukuysal, RL; Farber, SA; Wurtman, RJ | 1 |
| Geilen, CC; Haase, R; Reutter, W; Wieder, T | 1 |
| Cook, SJ; Wakelam, MJ | 2 |
| Kennerly, DA | 1 |
| Bates, TE; Bell, JD; Iles, RA; Rafter, JE | 1 |
| Dinh, TT; Kennerly, DA; Murray, JJ; Truett, AP | 1 |
| Kumaraswami, V; Lal, RB; Nutman, TB; Steel, C | 1 |
| Burt, CT; Chen, B | 1 |
| Mita, M; Ueta, N | 1 |
| Hellwig, D; Racké, K; Wessler, I | 1 |
| Choy, WF; Lim, PL | 1 |
| Blaser, K; Cinader, B; Gerber, VE; Heusser, CH; Ponnappan, U | 1 |
| Mookerjea, S; Nagpurkar, A; Randell, E | 1 |
| Lenzen, S; Rustenbeck, I | 1 |
| Djenderedjian, A; Fu, P; Hill, E; Jenden, DJ; Lin, KM; Miller, BL; Nuccio, C; Tang, C | 1 |
| Hara, I; Ohno, Y; Okazaki, M | 1 |
| Andersson, B; Briles, D; Brooks, JW; Edén, CS; Nordenstam, G; Odén, A; Svanborg, A | 1 |
| Hara, A; Sugiyama, E; Taketomi, T; Uemura, K | 1 |
| Amstutz, H; Blaser, K; Heusser, CH; Lötscher, M | 1 |
| Werhand, J; Wessler, I | 1 |
| Mortensen, RF; Swanson, SJ | 1 |
| Andriamampandry, C; Freysz, L; Kanfer, JN; Massarelli, R | 1 |
| Becker Dunn, E; Bottomly, K | 1 |
| Kim, BS; Massey, PB | 2 |
| Matsuura, M; Sugimura, K; Watanabe, T; Yamasaki, N | 1 |
| Couceiro, J; Eiras, A; Faro, J; Lareo, I; Regueiro, BJ; Seoane, R | 2 |
| Klinman, NR; Zharhary, D | 1 |
| Gualzata, M; Heusser, CH; Weiss, N | 1 |
| Arp, B; Brady, W; Brinster, RL; Engler, P; Gollahon, K; Manz, J; Pinkert, C; Storb, U | 1 |
| Gritzmacher, CA; Liu, FT | 1 |
| Burke, J; Denham, DA; Maizels, RM | 1 |
| Leiro, J; Sanmartín-Durán, ML; Santamarina, MT; Ubeira, FM; Villa, TG | 1 |
| Cerny, J; Gleason, JT; Strickland, FM | 1 |
| Leiro, J; Sanmartin-Duran, ML; Santamarina, MT; Ubeira, FM | 1 |
| Eiras, A; Faro, J; Lareo, I; Regueiro, BJ; Schiller, M; Seoane, R | 1 |
| Forsyth, KP; Kazura, JW; Wenger, JD | 1 |
| Brown, LR; Cornell, BA; Kaplin, IJ; Mendz, GL; Miller, DJ; Moore, WJ; Separovic, F | 1 |
| Kim, SY; Razzeca, KJ; Rouse, RV | 1 |
| Cancro, MP; Hilbert, DM | 2 |
| Leiro, J; Sanmartín, ML; Santamarina, MT; Sernández, L; Ubeira, FM | 1 |
| Mortensen, RF; Tseng, J | 1 |
| Bächinger, HP; Bruderer, U; Fellman, JH; Rittenberg, MB; Stenzel-Poore, MP | 1 |
| Bruccoleri, RE; Novotny, J; Saul, FA | 1 |
| Berry, J; Claflin, JL; Dell, C; George, J | 1 |
| Froscher, BG; Klinman, NR; Linton, PJ; Marcu, K; Riley, SC; Zharhary, D | 1 |
| Cazenave, PA; Coutinho, A; Martinez, C | 1 |
| Garadi, R; Jernigan, HM; Lou, MF; Mahendroo, PP; Thomas, DM; York, BM | 1 |
| Finkelman, F; Kenny, JJ; Kopp, WC; Longo, DL; Macchiarini, F; Storb, U | 1 |
| Feeney, AJ; Thuerauf, DJ | 1 |
| Rittenberg, MB; Stenzel-Poore, MP | 1 |
| Currier, PF; Infante, AJ | 1 |
| Cerny, J; Currier, P; Infante, AJ; Strickland, FM | 1 |
| Kanfer, JN; McCartney, DG | 3 |
| Barr, HA; Nicholas, TE; Power, JH | 1 |
| Endo, T; Inagaki, F; Roise, D; Shimada, I | 1 |
| Dani, HM; Misra, UK; Narayan, S | 1 |
| Bender, T; Claflin, JL; Hudak, S; Maddalena, A | 1 |
| Faro, J; Martínez Ubeira, F; Puentes, E; Regueiro, BJ; Seoane, R | 1 |
| Claflin, JL; Williams, RE; Young, NM | 1 |
| Jernigan, HM; Zigler, JS | 1 |
| Aebersold, P; Cohen, JS; Kaplan, O | 1 |
| Burke, JF; Gelfand, JA; Hales, CA; Li, JJ; McAdam, KP; Sanders, RL; Thompson, BT | 1 |
| Drapers, JA; Egbers, P; Groen, AK; Hoek, FJ; Noordam, C; Tytgat, GN | 1 |
| Klinman, NR; Linton, PJ; Manz, J; Pinkert, CA; Storb, U | 1 |
| Lal, RB; Ottesen, EA | 1 |
| Chapman, D; Urbaneja, MA | 2 |
| Blaser, K; Cinader, B; Gerber, V; Heusser, CH; Ponnappan, U | 2 |
| al-Joburi, W; Chan, EC; Gornitsky, M; Siboo, R | 1 |
| Bocckino, SB; Domino, SE; Garbers, DL | 1 |
| Breiser, A; Damenz, W; Eibl, H; Engel, J; Fleer, EA; Hilgard, P; Kim, DJ; Nagel, G; Unger, C | 1 |
| Cerny, J; Cronkhite, RI; Strickland, FM | 1 |
| Byers, DM; Cook, HW; George, TP; Morash, SC; Palmer, FB; Spence, MW | 1 |
| Murray, JJ; Snyderman, R; Truett, AP | 1 |
| Heusser, C; Masson, D; Peitsch, MC; Schäfer, S; Tschopp, J | 1 |
| Dworkin, J; Mar, A; Oró, J | 1 |
| Bennet, PJ; Chap, HJ; Douste-Blazy, L; Laneelle, G; Mansat, A; Mieusset, R; Moatti, JP; Nieto, M; Pontonnier, F | 1 |
| Reinhardt, RR; Wecker, L | 1 |
| Martin, TW | 1 |
| Martin, TW; Michaelis, KC | 1 |
| Chap, H; Douste-Blazy, L; Record, M; Ribbes, G; Tercé, F | 1 |
| Andersson, B; Bengtsson, C; Briles, D; Nordenstam, G; Scott, G; Svanborg Edén, C; Svanborg, A | 1 |
| Blusztajn, JK; Zeisel, SH | 1 |
| Bligny, R; Douce, R; Foray, MF; Roby, C | 1 |
| Kenny, JJ; Singer, A; Wicker, LS | 1 |
| Callahan, JW; Strasberg, PM | 1 |
| Kent, C; Morand, JN; Wright, PS | 1 |
| Brown, ND; Nelson, LD; Wiesmann, WP | 1 |
| Kimura, G; Nomoto, K; Okubo, A; Onodera, K; Suzuki, T; Yasumoto, K | 1 |
| Cooper, DR; Farese, RV; Nair, GP; Pollet, RJ; Standaert, ML | 1 |
| Gualzata, MD; Heusser, CH; Rudin, W; Weiss, N | 1 |
| Breiser, A; Eibl, H; Engel, J; Hilgard, P; Nagel, GA; Peukert, M; Sindermann, H; Unger, C; von Heyden, HW | 1 |
| Loken, MR; Quintáns, J; Stall, AM | 1 |
| Aebersold, RH; Brown, M; Chang, SP; Glanville, RW; Rittenberg, MB | 1 |
| Cerny, J; Cronkhite, RI | 1 |
| Cohen, GH; Davies, DR; Padlan, EA; Satow, Y | 1 |
| Berry, J; Claflin, JL; Dunnick, W; Flaherty, D | 1 |
| Chien, NC; Giusti, AM; Scharff, MD; Shin, SU; Zack, DJ | 1 |
| Hall, TJ | 2 |
| Eiras, A; Faro, J; Lareo, I; Regueiro, BJ; Seoane, R | 1 |
| Bass, JA; Krieg, DP; Mattingly, SJ | 1 |
| Chien, NC; Desaymard, C; Pollock, RR; Scharff, MD | 1 |
| Clarke, SH; Feeney, AJ; Mosier, DE | 1 |
| Berger, MR; Eibl, H; Engel, J; Hilgard, P; Schumacher, W; Stekar, J; Unger, C; Voegeli, R | 1 |
| Berry, J; Claflin, JL | 1 |
| Guelde, G; Kenny, JJ; Scher, I; Wicker, LS | 3 |
| Hathcock, KS; Hodes, RJ; Kenny, JJ | 1 |
| Freijd, A; Jonsson, A; Rynnel-Dagöö, B | 1 |
| Altman, D; Kohler, H; Lim, PL; McNamara-Ward, M; Tucker, PW; Ward, RE; Webb, CF | 1 |
| Gearhart, PJ; Levy, NS; Malipiero, UV | 1 |
| Leiro, J; Regueiro, BJ; Seoane, R; Ubeira, FM | 1 |
| Blaser, K; Heusser, CH | 2 |
| Blalock, JE; Brunck, TK; Kang, CY; Kieber-Emmons, T; Kohler, H | 1 |
| Dennis, EA; Hazlett, TL | 1 |
| Aebersold, R; Blaser, K; Bruderer, U; Heusser, CH | 1 |
| Berger, MR; Eibl, HJ; Muschiol, C; Schmähl, D | 1 |
| Berger, M; Breiser, A; Damenz, W; Drube, A; Eibl, H; Fleer, EA; Kim, DJ; Nagel, GA; Unger, C | 1 |
| Berger, MR; Scherf, HR; Schmähl, D; Schuler, B | 1 |
| Berger, MR; Eibl, HJ; Garzon, FT; Muschiol, C; Scherf, HR; Schmähl, D; Schuler, B; Unger, C; Zeller, WJ | 1 |
| Calderon, RA; Shennan, GI | 1 |
| Pollack, SJ; Schultz, PG | 1 |
| Etlinger, HM; Heusser, CH | 2 |
| Pillemer, E; Razzeca, KJ; Rouse, RV; Weissman, IL | 1 |
| Barbier, E; Cazenave, PA; Drapier, AM; Primi, D | 1 |
| Briles, DE; Nahm, MH; Scott, MG; Shackelford, PG; Smith, DS | 1 |
| Blaese, M; Briles, DE; Crain, MJ; Gray, B; Haber, P; Nahm, M; Scott, G; Scott, V | 1 |
| Hoppe, CA; Kawaguchi, K; Kohda, S; Koishi, T; Lee, YC; Liu, TY; Stults, NL; Takagahara, I | 1 |
| Ancelin, ML; Capron, A; Torpier, G; Vial, HJ | 1 |
| Chan, JH; Croft, SL; Neal, RA; Pendergast, W | 1 |
| Arienti, G; Corazzi, L; Marku, N; Piccinin, GL | 1 |
| Chapman, D; Durrani, AA; Hayward, JA | 1 |
| Chapman, D; Durrani, AA; Hayward, JA; Lee, DC; Shelton, CJ | 1 |
| Sørensen, UB | 1 |
| Blaser, K; Heusser, CH; Weber, EA | 1 |
| Lehtonen, OP | 1 |
| Cunningham-Rundles, C | 1 |
| Cacciatore, L; Cerini, R; Cocozza, M; Coto, V; Lingetti, M; Lucariello, A; Oliviero, U; Porfido, FA; Scarpellino, F; Talarico, M | 1 |
| Rifai, A; Wong, SS | 1 |
| Jacobs, JW; Pollack, SJ; Schultz, PG | 1 |
| Allen, W; McWilliam, AS; Stewart, GA | 1 |
| de Haas, GH; Maki, AH; Mao, SY | 2 |
| Almond, NM; Parkhouse, RM | 1 |
| Chander, A; Dodia, C; Fisher, AB; Yost, RW | 1 |
| Fouilland, L; Gagniarre, J; Lecerf, J | 1 |
| Blalock, E; Cerny, J; Hamilton, SL; Strickland, FM | 1 |
| Kohler, H; Smyk, S | 1 |
| Cerny, J; Stout, JT; Strickland, FM | 1 |
| Brown, M; Rittenberg, MB; Todd, I | 1 |
| Claflin, JL; Lieberman, R; Nishinarita, S | 1 |
| Brown, M; Rittenberg, MB; Stenzel-Poore, M | 1 |
| Mookerjea, S; Nagpurkar, A; Saxena, U | 1 |
| Karczmar, AG; Kindel, G; Rosenberg, A; Saito, M | 1 |
| Binaglia, L; Dreyfus, H; Freysz, L; Golly, F; Massarelli, R; Porcellati, G | 1 |
| Chiti, D; Ligas, B; Proietti, C | 3 |
| Chiti, D; Imperiale, A; Proietti, C | 2 |
| Chap, H; Douste-Blazy, L; Record, M; Tamer, AE | 1 |
| Bastin, B; Dupuis, G | 1 |
| Cooper, PD | 1 |
| Cheney, DL; Costa, E; Racagni, G; Trabucchi, M; Wang, C | 2 |
| Brown, LR; Martenson, RE; Mendz, GL; Moore, WJ | 1 |
| Giudicelli, S; Tomasz, A | 1 |
| Fung, J; Köhler, H | 2 |
| Benca, R; Flood, PM; Kearney, JF; Quintáns, J; Schreiber, H | 1 |
| Kearney, JF; Volanakis, JE | 1 |
| Kearney, JF; Kilpatrick, JM; Roux, KH; Volanakis, JE | 1 |
| Sigal, NH; Stein, LD | 1 |
| Agger, R; Bennedsen, J; Henrichsen, J; Sørensen, UB | 1 |
| Kearney, JF; Pollok, BA; Stohrer, R | 1 |
| Cerny, J; Cronkhite, R | 1 |
| Gleason, K; Kohler, H; McNamara, M | 1 |
| Beckmann, E; Levitt, D | 1 |
| Feeney, AJ; Mosier, DE | 2 |
| Harita, S; Sugimura, K; Watanabe, T | 1 |
| Lévy, M | 2 |
| Ono, Y; Yoshie, O | 1 |
| Bösch, C; Brown, LR; Wüthrich, K | 1 |
| Brooks, RL; Feldman, DA; Miller, JC; Quade, MM; Weinhold, PA | 1 |
| Callahan, JW; Davidson, DJ; Jones, CS | 1 |
| Dwek, RA; Gettins, P; Leatherbarrow, RJ; Pótter, M | 1 |
| Liu, TY; Robey, FA | 1 |
| Douste-Blazy, L; Levade, T; Salvayre, R | 1 |
| Harwood, JL; Price-Jones, MJ | 1 |
| Akamatsu, Y; Kuge, O; Maeda, M; Nakano, A; Nishijima, M | 1 |
| Jenden, DJ; Paglia, DE; Valentine, WN | 1 |
| Briles, DE; Claflin, JL; Forman, C; Hudak, S | 2 |
| Quan, ZS; Quintáns, J | 1 |
| Birmingham, W; Lindsay, TJ; Munster, AM; Winchurch, RA | 1 |
| Robey, FA; Tanaka, T | 1 |
| Du Clos, TW; Gewurz, H; Mold, C; Nakayama, S | 1 |
| Bach, MA; Beckmann, E; Levitt, D | 2 |
| Claflin, JL; Clarke, SH; Potter, M; Rudikoff, S | 1 |
| Clarke, SH; Kenny, JJ; Rudikoff, S; Sieckmann, DG | 1 |
| Brown, M; Chang, SP; Heusser, CH; Hood, L; Perlmutter, RM; Rittenberg, MB | 1 |
| Aebersold, R; Chang, SP; Heusser, CH; Hood, L; Perlmutter, RM; Rittenberg, MB; Todd, I | 1 |
| Claflin, JL; Hudak, S; Pierce, JW | 1 |
| Crews, ST; Douglas, R; Gearhart, PJ; Hood, L; Johnson, N; Nivera, N; Perlmutter, RM; Sorensen, G | 1 |
| Hamaoka, T; Kohmo, T; Mizuochi, T; Yamamoto, H | 1 |
| Kishimoto, T; Maeda, K; Sugimura, K; Yamamura, Y | 1 |
| Batenburg, JJ; Post, M; Smith, BT; Van Golde, LM | 1 |
| Briles, DE; Conley, ME | 1 |
| Benjamin, WH; Briles, DE; Forman, C; McDaniel, LS | 1 |
| Ikeda, K; Samejima, Y; Sano, S; Teshima, K | 1 |
| Belardelli, F; Carpinelli, G; Di Vito, M; Gessani, S; Podo, F; Proietti, E | 1 |
| Ahmed, A; Kenny, JJ; Metcalf, ES; Yaffe, LJ | 1 |
| Budinger, TF; Friedland, RP; Mathis, CA; Moyer, BR; Rosen, M | 1 |
| Klinman, NR; Stone, MR | 1 |
| Hamaguchi, K; Hayashi, K; Ikeda, K; Teshima, K | 2 |
| Hara, A; Taketomi, T | 1 |
| Oshima, T; Sugane, K | 1 |
| Brown, M; Rittenberg, MB; Schiffman, G | 1 |
| Robinson, BS; Runciman, WB; Snoswell, AM; Upton, RN | 1 |
| Gilad, GM; Gilad, VH | 1 |
| Berek, C; Cosenza, H; Jaton, JC; Kocher, HP; Schreier, MH | 1 |
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10 review(s) available for phosphorylcholine and choline
| Article | Year |
|---|---|
Pharmacological implications of brain acetylcholine turnover measurements in rat brain nuclei.
Topics: Acetylcholine; Analgesics, Opioid; Anesthetics; Animals; Barbiturates; Brain; Brain Chemistry; Central Nervous System Stimulants; Choline; gamma-Aminobutyric Acid; Hallucinogens; In Vitro Techniques; Isotope Labeling; Kinetics; Parasympatholytics; Parasympathomimetics; Phosphorylcholine; Postmortem Changes; Rats; Receptors, Dopamine; Receptors, Drug; Sodium | 1977 |
The response to phosphorylcholine: dissecting an immune response.
Topics: Animals; Antibodies; Antibodies, Anti-Idiotypic; Antibody Formation; Antigen-Antibody Reactions; Binding Sites, Antibody; Cells, Cultured; Choline; Epitopes; Immune Sera; Immune Tolerance; Immunity; Immunization; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Phosphorylcholine; Rabbits; Spleen; Stimulation, Chemical | 1975 |
Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.
Topics: Animals; Animals, Newborn; Autoantibodies; B-Lymphocytes; Binding Sites, Antibody; Choline; Female; Haptens; Immunity, Cellular; Immunoglobulin Variable Region; Immunosuppression Therapy; Maternal-Fetal Exchange; Mice; Mice, Inbred BALB C; Phosphorylcholine; Pregnancy; Spleen; T-Lymphocytes | 1977 |
Biochemical consequences of phosphorylcholines low pK with special relevance to human semen: passive pH regulation.
Topics: Alkaline Phosphatase; Animals; Choline; Humans; Hydrogen-Ion Concentration; Models, Chemical; Phosphorylcholine; Semen | 1990 |
Somatic mutation in anti-phosphorylcholine antibodies.
Topics: Animals; Antibodies; Antibody Affinity; Antigens; B-Lymphocytes; Base Sequence; Choline; DNA; Immunoglobulin Variable Region; Mice; Models, Genetic; Mutation; Phosphorylcholine | 1987 |
The IgE antibody response to the phosphorylcholine hapten.
Topics: Antibody Formation; Antibody Specificity; Choline; Haptens; Hemocyanins; Immunoglobulin E; Immunoglobulin Idiotypes; Phosphorylcholine | 1987 |
The generation of diversity in phosphorylcholine-binding antibodies.
Topics: Animals; Antibody Diversity; Choline; Clone Cells; Genes; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Variable Region; Mice; Mutation; Phosphorylcholine; Recombination, Genetic | 1984 |
Binding of C-reactive protein to C-carbohydrate and PC-substituted protein.
Topics: Animals; Binding Sites; C-Reactive Protein; Calcium; Chemical Phenomena; Chemistry; Choline; Ethanolamines; Humans; Organophosphorus Compounds; Phosphorylcholine; Polysaccharides, Bacterial; Protein Binding | 1982 |
Structure and function of choline kinase isoforms in mammalian cells.
Topics: Amino Acid Sequence; Animals; Cell Division; Choline; Choline Kinase; Humans; Isomerism; Liver; Mammals; Neoplasms; Organophosphorus Compounds; Phosphatidylcholines; Phosphorylcholine; Rats; Signal Transduction; Tissue Distribution | 2004 |
Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients.
Topics: Antipsychotic Agents; Bipolar Disorder; Brain; Choline; Creatine; Dextroamphetamine; Female; Humans; Lithium Carbonate; Magnetic Resonance Spectroscopy; Male; Phosphorylcholine; Time Factors; Valproic Acid | 2004 |
7 trial(s) available for phosphorylcholine and choline
| Article | Year |
|---|---|
[Double-blind evaluation of the antidyslipidemic effect of a combined phosphorylcholine and pantetheine product].
Topics: Adult; Aged; Choline; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Humans; Hyperlipidemias; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds | 1985 |
[Double-blind trial on the trophic and anti-atherosclerotic preventive efficacy of a phosphorylcholine-pantetheine combination].
Topics: Aged; Arteriosclerosis; Choline; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Humans; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds | 1985 |
[Clinical study of the lipotropic activity of the preparation Fosfolip].
Topics: Adult; Aged; Arteriosclerosis; Choline; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hyperlipidemias; Lipids; Liver Diseases; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds | 1983 |
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.
Topics: Adult; Betaine; Choline; Diet; Diet Records; Dietary Supplements; Female; Genotype; Humans; Lactation; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Milk, Human; Nutrition Policy; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphorylcholine; Polymorphism, Single Nucleotide; Pregnancy; Young Adult | 2010 |
Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Attention; Brain; Child, Preschool; Choline; DNA Mutational Analysis; Electroencephalography; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Infant; Infant, Newborn; Male; Neural Inhibition; Nootropic Agents; Perinatal Care; Phosphorylcholine; Pregnancy; Randomized Controlled Trials as Topic; Receptors, Nicotinic; Schizophrenia; Sensory Gating; Signal Processing, Computer-Assisted | 2013 |
Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.
Topics: Aged; Aged, 80 and over; Betaine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chi-Square Distribution; Choline; Chromatography, Liquid; Diet, Mediterranean; Female; Humans; Incidence; Male; Metabolomics; Methylamines; Middle Aged; Multivariate Analysis; Phospholipid Ethers; Phosphorylcholine; Proportional Hazards Models; Prospective Studies; Risk Factors; Spain; Tandem Mass Spectrometry; Time Factors; Treatment Outcome | 2017 |
Different choline supplement metabolism in adults using deuterium labelling.
Topics: Adult; Betaine; Choline; Cross-Over Studies; Deuterium; Fatty Acids; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Phosphatidylcholines; Phosphorylcholine; Prospective Studies | 2023 |
630 other study(ies) available for phosphorylcholine and choline
| Article | Year |
|---|---|
Binding of phosphorylcholine to an IgM Waldenström as studied by fluorescence spectroscopy and circular dichroism.
Topics: Animals; Choline; Circular Dichroism; Guanidines; Humans; Hydrogen-Ion Concentration; Immunoglobulin M; Mice; Myeloma Proteins; Phosphorylcholine; Protein Binding; Protein Denaturation; Spectrometry, Fluorescence; Tryptophan; Urea; Waldenstrom Macroglobulinemia | 1976 |
Antibody response to phosphorylcholine in vitro. II. Analysis of T-dependent and T-independent responses.
Topics: Animals; Antibody Formation; B-Lymphocytes; Binding Sites, Antibody; Carrier Proteins; Choline; Clone Cells; Female; Hemocyanins; Immunoglobulin Allotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Spleen; Streptococcus pneumoniae; T-Lymphocytes | 1976 |
Choline metabolism in pneumococci.
Topics: Cell Wall; Choline; Choline Kinase; Cytidine Diphosphate Choline; Nucleotidyltransferases; Phosphorylcholine; Streptococcus pneumoniae; Teichoic Acids | 1977 |
A rapid accurate assay for choline kinase.
Topics: Adenosine Triphosphate; Animals; Choline; Choline Kinase; Chromatography, Paper; Haplorhini; Hydrogen-Ion Concentration; Lung; Macaca mulatta; Magnesium; Methods; Phosphorylcholine; Phosphotransferases; Saccharomyces cerevisiae | 1977 |
Isoelectric focus analysis of rat anti-phosphocholine antibodies.
Topics: Animals; Antibodies; Antibody Formation; Choline; Female; Immunization; Isoelectric Focusing; Molecular Weight; Phosphorylcholine; Rats; Species Specificity; Streptococcus pneumoniae | 1977 |
Molecular studies of subspecificity differences among phosphorylcholine-binding mouse myeloma antibodies using 31P nuclear magnetic resonance.
Topics: Binding Sites, Antibody; Choline; Glycerylphosphorylcholine; Haptens; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Myeloma Proteins; Phosphorylcholine; Protein Binding; Structure-Activity Relationship | 1978 |
Affinity of horse anti-phosphorylcholine antibodies for some pneumococcal polysaccharides. Contribution of the polysaccharide backbone.
Topics: Animals; Antibody Specificity; Binding Sites, Antibody; Choline; Horses; Phosphorylcholine; Polysaccharides, Bacterial; Streptococcus pneumoniae; Teichoic Acids | 1978 |
Comparison of the secondary structures and binding sites of C-reactive protein and the phosphorylcholine-binding murine myeloma proteins.
Topics: Animals; Bacterial Proteins; Binding Sites; C-Reactive Protein; Choline; Circular Dichroism; Humans; Immunoglobulin A; Mice; Myeloma Proteins; Phospholipids; Phosphorylcholine; Protein Binding; Spectrometry, Fluorescence; Streptococcus pneumoniae | 1978 |
Induction of anti-phosphorylcholine antibodies of restricted heterogeneity in rabbits.
Topics: Animals; Antibodies, Bacterial; Antibodies, Heterophile; Antibody Specificity; Bacterial Vaccines; Choline; Electrophoresis, Polyacrylamide Gel; Immunodiffusion; Isoelectric Focusing; Phosphorylcholine; Rabbits; Spectrometry, Fluorescence; Streptococcus pneumoniae | 1978 |
Structure of a phosphorycholine-binding mouse myeloma Fab.
Topics: Binding Sites, Antibody; Choline; Crystallography; Epitopes; Haptens; Immunochemistry; Immunoglobulin Fab Fragments; Multiple Myeloma; Phosphorylcholine | 1975 |
[Effect of injection of a phosphorylcholine-containing compound from Nippostrongylus brasiliensis on the infestation of the rat by this parasite].
Topics: Ancylostomatoidea; Animals; Choline; Epitopes; Female; Hookworm Infections; Immunization; Intestine, Small; Lung; Nippostrongylus; Phosphorylcholine; Rats | 1975 |
Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibody Formation; Antibody Specificity; Antibody-Producing Cells; Binding Sites, Antibody; Cells, Cultured; Choline; Epitopes; Immunoglobulins; Mice; Mice, Inbred Strains; Phosphorylcholine; Spleen; T-Lymphocytes | 1975 |
The chemical nature of the combining site of rabbit anti-p-azophenylphosphorylcholine antibody.
Topics: Acetamides; Amino Acids; Antibodies; Antigen-Antibody Reactions; Arginine; Azo Compounds; Binding Sites, Antibody; Carboxylic Acids; Choline; Epitopes; Esterification; Furans; Haptens; Lysine; Phosphorylcholine | 1976 |
Immune response to phosphorylcholine. I. Characterization of the epitope-specific antibody.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Binding Sites, Antibody; Choline; Clone Cells; Cross Reactions; Epitopes; Female; Haptens; Immunoglobulin Light Chains; Immunoglobulin M; Immunoglobulin mu-Chains; Isoelectric Focusing; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1976 |
Inhibition of platelet aggregation by a myeloma protein with anti-phosphocholine specificity.
Topics: Antigen-Antibody Reactions; C-Reactive Protein; Choline; gamma-Globulins; Humans; Immunoglobulin A; Myeloma Proteins; Phosphorylcholine; Platelet Aggregation; Receptors, Drug; Thrombin | 1976 |
Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies, Anti-Idiotypic; Antigen-Antibody Reactions; Choline; Epitopes; Immunoglobulin Allotypes; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1976 |
Expression of equivalent clonotypes in BALB/c and A/J mice after immunization with phosphorylcholine.
Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites, Antibody; Biological Evolution; Choline; Clone Cells; Epitopes; Genes; Immunoglobulin Allotypes; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Isoelectric Focusing; Mice; Mice, Inbred A; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1976 |
Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice.
Topics: Animals; Antibody Formation; Binding Sites, Antibody; Choline; Clone Cells; Epitopes; Immunoglobulin Light Chains; Immunoglobulin M; Isoelectric Focusing; Mice; Mice, Inbred Strains; Myeloma Proteins; Phosphorylcholine; Species Specificity | 1976 |
The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire.
Topics: Animals; Antibody Formation; Antibody Specificity; Binding Sites, Antibody; Choline; Epitopes; Genes; Immunoglobulin Allotypes; Mice; Phosphorylcholine | 1977 |
Prenatal diagnosis of Niemann-Pick disease type A using chromogenic substrate.
Topics: Amniotic Fluid; Choline; Female; Fibroblasts; Humans; Niemann-Pick Diseases; Phosphorylcholine; Pregnancy; Prenatal Diagnosis; Skin; Sphingomyelins | 1977 |
Idiotypes and anti-idiotypes as probes in analysis of immunoregulation.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; B-Lymphocytes; Choline; Cross Reactions; Epitopes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine; Receptors, Antigen, B-Cell; T-Lymphocytes | 1977 |
Uniformity in a clonal repertoire: a case for a germ-line basis of antibody diversity.
Topics: Animals; Antibodies; Antibody Specificity; Choline; Clone Cells; Cross Reactions; Epitopes; Immunoglobulin Light Chains; Immunoglobulins; Mice; Mice, Inbred Strains; Myeloma Proteins; Phosphorylcholine; Species Specificity | 1977 |
The histochemical demonstration of human prostatic acid phosphatase with phosphorylcholine.
Topics: Acid Phosphatase; Choline; Epithelium; Golgi Apparatus; Humans; In Vitro Techniques; Lysosomes; Male; Phosphorylcholine; Prostate; Prostatic Hyperplasia; Vacuoles | 1977 |
Immune response to phosphorylcholine. I.V. Comparison of homologous and isologous anti-idiotypic antibody.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibody Specificity; Choline; Epitopes; Female; Immunoglobulin G; Mice; Mice, Inbred Strains; Phosphorylcholine | 1978 |
Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
Topics: Aging; Animals; Animals, Newborn; Antibody Formation; B-Lymphocytes; Choline; Clone Cells; Epitopes; Immunoglobulin Variable Region; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1977 |
Specific antigens inhibit plasmacytoma cells bearing phosphorylcholine-binding myeloma proteins.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Choline; Epitopes; Fluorescent Antibody Technique; Lymphocytes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine; Plasmacytoma; Protein Binding | 1978 |
Axonal transport of lipid in goldfish optic axons.
Topics: Acetylcholine; Animals; Axonal Transport; Axons; Choline; Eye; Glycerol; Goldfish; Lipid Metabolism; Nerve Tissue Proteins; Optic Nerve; Phosphorylcholine; Serine; Superior Colliculi | 1978 |
Binding studies with antibodies having phosphorylcholine specificity and fragments derived from their homologous Streptococcus pneumoniae type 27 capsular polysaccharide.
Topics: Animals; Binding Sites, Antibody; Choline; Epitopes; Oligosaccharides; Phosphorylcholine; Polysaccharides, Bacterial; Rabbits; Streptococcus pneumoniae | 1979 |
Effects of chronic lead exposure on levels of acetylcholine and choline and on acetylcholine turnover rate in rat brain areas in vivo.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Female; Kinetics; Lead Poisoning; Male; Phosphorylcholine; Rats | 1978 |
kappa Chain variable region from M167, a phosphorylcholine binding myeloma protein.
Topics: Amino Acid Sequence; Binding Sites, Antibody; Choline; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Myeloma Proteins; Peptide Fragments; Phosphorylcholine | 1978 |
Idiotypic cross-reactivity of human and murine phosphorylcholine-binding immunoglobulins.
Topics: Animals; Binding Sites, Antibody; Binding, Competitive; Choline; Clone Cells; Cross Reactions; Humans; Immune Sera; Immunoglobulin Idiotypes; Immunoglobulin M; Iodine Radioisotopes; Mice; Phosphorylcholine; Rabbits; Waldenstrom Macroglobulinemia | 1979 |
Pentobarbital and in vivo turnover rate of acetylcholine in mouse brain and in regions of rat brain.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Choline; Corpus Striatum; Depression, Chemical; Feedback; Fenclonine; Kinetics; Male; Mice; Pentobarbital; Phosphorylcholine; Rats; Sleep Deprivation; Sleep, REM | 1975 |
Equilibrium constants under physiological conditions for the reactions of choline kinase and the hydrolysis of phosphorylcholine to choline and inorganic phosphate.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Choline; Choline Kinase; Hydrolysis; Kinetics; Magnesium; Mathematics; Phosphorylcholine; Phosphotransferases; Protein Binding; Saccharomyces cerevisiae | 1976 |
Mechanism of heparin and serum lipoprotein interaction: effects of calcium, phosphorylcholine, and a serum fraction.
Topics: Animals; Arteriosclerosis; Blood Proteins; Calcium; Chemical Phenomena; Chemical Precipitation; Chemistry; Choline; Chylomicrons; Heparin; Lipoproteins; Lipoproteins, VLDL; Male; Phosphorylcholine; Rats | 1978 |
A micromethod for sphingomyelinase assay using a chromogenic artificial substrate. Its use in the diagnosis of Niemann-Pick disease.
Topics: Adolescent; Child; Child, Preschool; Choline; Female; Fibroblasts; Humans; Male; Methods; Niemann-Pick Diseases; Nitrophenols; Phosphoric Diester Hydrolases; Phosphorylcholine; Sphingomyelin Phosphodiesterase | 1979 |
Specific recognition of choline residues in the cell wall teichoic acid by the N-acetylmuramyl-L-alanine amidase of Pneumococcus.
Topics: Alanine; Amidohydrolases; Amino Acids; Cell Wall; Choline; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Ethanolamines; Galactosamine; Glucosamine; Hydrolysis; Kinetics; Muramic Acids; Phosphorylcholine; Streptococcus pneumoniae; Teichoic Acids; Time Factors | 1975 |
A practical chromogenic procedure for the detection of homozygotes and heterozygous carriers of Niemann-Pick disease.
Topics: Amniotic Fluid; Cells, Cultured; Cerebrosides; Choline; Clinical Enzyme Tests; Fibroblasts; Glucosylceramidase; Heterozygote; Homozygote; Humans; Hydrogen-Ion Concentration; Hydrolysis; Leukocytes; Liver; Niemann-Pick Diseases; Nitrophenols; Phosphoric Diester Hydrolases; Phosphorylcholine; Proteins; Skin; Sphingomyelin Phosphodiesterase; Sphingomyelins | 1975 |
Recognition of a naturally occurring idiotype by autologous T cells.
Topics: Animals; Antibody Formation; B-Lymphocytes; Carrier Proteins; Choline; Dinitrobenzenes; Haptens; Immunoglobulin Allotypes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine; T-Lymphocytes | 1977 |
Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.
Topics: Animals; B-Lymphocytes; Carrier Proteins; Choline; Female; Genes; Genetic Linkage; Haptens; Immunoglobulin Allotypes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Phosphorylcholine; Sex Chromosomes; Spleen | 1977 |
Expression of phosphorylcholine-specific B cells during murine development.
Topics: Animals; Animals, Newborn; Antibodies; B-Lymphocytes; Bone Marrow; Choline; Clone Cells; Genes; Germ-Free Life; Immunoglobulin Allotypes; Liver; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine; Spleen | 1977 |
Clonal dominance: loss and restoration in adoptive transfer.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Differentiation; Choline; Clone Cells; Immunization, Passive; Immunoglobulin Variable Region; Liver; Mice; Phosphorylcholine; Spleen | 1978 |
[Renal changes induced by the acute lack of choline in adult rats].
Topics: Acute Disease; Animals; Choline; Choline Deficiency; Diet; Female; Kidney; Liver; Liver Regeneration; Male; Phosphorylcholine; Rats | 1978 |
Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigens, Surface; B-Lymphocytes; Choline; Hemocyanins; Immunoglobulin Idiotypes; Immunologic Memory; Immunosuppression Therapy; Lymphocyte Cooperation; Mice; Mice, Inbred BALB C; Phenotype; Phosphorylcholine; T-Lymphocytes | 1978 |
Phosphorylcholine-specific helper T cells in mice with an X-linked defect of antibody production to the same hapten.
Topics: Animals; Antibody Formation; B-Lymphocytes; Choline; Female; Genes; Genetic Linkage; Haptens; Immunoglobulin Idiotypes; Lymphocyte Cooperation; Mice; Phosphorylcholine; Radiation Chimera; T-Lymphocytes; X Chromosome | 1979 |
The central role of phosphorylcholine in the metabolism of epidermis in the guinea-pig, Cavia porcellus.
Topics: Animals; Choline; Epidermis; Guinea Pigs; Phosphorylcholine | 1978 |
Functional, structural, and antigenic similarities of guinea pig anti-phosphorylcholine antibodies.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; Choline; Genotype; Guinea Pigs; Hemocyanins; Hemolytic Plaque Technique; Immune Sera; Immunoglobulin G; Immunoglobulin M; Isoelectric Focusing; Male; Phosphorylcholine; Vaccines | 1977 |
Ascaris suum: location of phosphorylcholine in lung larvae.
Topics: Animals; Antigens; Ascariasis; Ascaris; Choline; Fluorescent Antibody Technique; Larva; Lung; Male; Mice; Myeloma Proteins; Phosphorylcholine | 1977 |
Failure of CBA/N mice to respond to thymus-dependent and thymus-independent phosphorylcholine antigens.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigens; B-Lymphocytes; Choline; Female; Hemolytic Plaque Technique; Immunization; Male; Mice; Mice, Inbred Strains; Phosphorylcholine; T-Lymphocytes | 1978 |
The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens.
Topics: Aging; Animals; Antibody Formation; Antigens; Choline; Female; Haptens; Hemolytic Plaque Technique; Kinetics; Mice; Mice, Inbred NZB; Phosphorylcholine; Thymus Gland | 1978 |
Immune response to phosphorylcholine--V. Dissociation of idiotypic complexes by complement.
Topics: Animals; Antibody Formation; Antibody Specificity; Antigen-Antibody Complex; Choline; Complement System Proteins; Immunoglobulin Idiotypes; Immunologic Techniques; Mice; Mice, Inbred A; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1978 |
Preparation of stable erythrocyte target cells suitable for detection of the antibody response to the haptens azobenzenearsonate, azophenyltrimethylammonium and azophenylphosphorylcholine by plaque-forming cell assay.
Topics: Animals; Antibody Formation; Azo Compounds; Choline; Erythrocytes; Female; Haptens; Hemolytic Plaque Technique; Mice; p-Azobenzenearsonate; Phosphorylcholine; Quaternary Ammonium Compounds | 1979 |
Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice.
Topics: Animals; Antibody Specificity; B-Lymphocytes; Cattle; Choline; Hemocyanins; Hemolytic Plaque Technique; Immunoglobulin E; Immunoglobulin M; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Passive Cutaneous Anaphylaxis; Phosphorylcholine; Serum Albumin, Bovine | 1979 |
Structure-function relations in phosphorylcholine-binding mouse myeloma proteins.
Topics: Binding Sites, Antibody; Cell Line; Choline; Haptens; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Magnetic Resonance Spectroscopy; Myeloma Proteins; Neoplasms, Experimental; Phosphates; Phosphorylcholine; Plasmacytoma; Protein Binding; Structure-Activity Relationship | 1977 |
Production of antibodies against phosphocholine, phosphatidylcholine, sphingomyelin, and lipid A by injection of liposomes containing lipid A.
Topics: Animals; Antibody Formation; Antibody Specificity; Choline; Glucose; Immunization; Lipid A; Lipopolysaccharides; Liposomes; Male; Phosphatidylcholines; Phosphorylcholine; Rabbits; Sphingomyelins | 1979 |
Determination of free choline and phosphorylcholine in rat liver.
Topics: Animals; Choline; Diet; Liver; Male; Methods; Phosphorylcholine; Rats | 1979 |
The effects of muscarinic receptor blockers on the turnover rate of acetylcholine in various regions of the rat brain.
Topics: Acetylcholine; Animals; Benztropine; Brain; Choline; Feedback; Kinetics; Male; Nerve Tissue Proteins; Parasympatholytics; Phenoxybenzamine; Phosphorylcholine; Rats; Scopolamine; Trihexyphenidyl | 1979 |
The membrane binding of choline acetyltransferase: uptake and acetylation of [3H]-choline in rabbit cortical slices.
Topics: Acetylation; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; In Vitro Techniques; Male; Membranes; Phosphorylcholine; Rabbits | 1979 |
Contributions by ionic and steric features of ligands to their binding with phosphorylcholine-specific immunoglobulin IgA H-8 as determined by fluorescence spectroscopy.
Topics: Animals; Calorimetry; Choline; Immunoglobulin A; Immunoglobulin Fab Fragments; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Neoplasms, Experimental; Phosphorylcholine; Plasmacytoma; Protein Conformation; Quaternary Ammonium Compounds; Spectrometry, Fluorescence | 1979 |
A new neuronal marker identified by phosphorylcholine-binding myeloma proteins.
Topics: Animals; Cells, Cultured; Choline; Ganglia, Spinal; Mice; Myeloma Proteins; Neurons; Phosphorylcholine; Spinal Cord | 1979 |
Phosphorylcholine-containing allergens.
Topics: Allergens; Animals; Ascaris; C-Reactive Protein; Choline; Dust; Fungi; Humans; Hypersensitivity; Immunoglobulin A; Immunoglobulin E; Mites; Myeloma Proteins; Phosphorylcholine; Skin Tests | 1979 |
Suppression of phosphorylcholine-specific IgE antibody formation in BALB/c mice by isologous anti-T 15 antiserum.
Topics: Animals; Antibody Formation; Choline; Female; Immune Sera; Immunoglobulin E; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1979 |
Magnetic resonance studies of the binding site interactions between phosphorylcholine and specific mouse myeloma immunoglobulin.
Topics: Animals; Binding Sites, Antibody; Choline; Haptens; Immunoglobulin A; Immunoglobulin Fab Fragments; Kinetics; Magnetic Resonance Spectroscopy; Mice; Myeloma Proteins; Phosphorylcholine; Protein Conformation | 1977 |
The effect of acute ethanol administration on phosphorylcholine uptake and metabolism in rat liver slices.
Topics: Alcoholic Intoxication; Animals; Choline; Ethanol; Female; Glycerophosphates; Humans; Liver; Phosphorylcholine; Rats; Triglycerides | 1979 |
Reaction of house dust mite extracts with mouse anti-phosphorylcholine and anti-galactan myeloma proteins.
Topics: Allergens; Animals; Choline; Dust; Galactose; Immunoglobulin A; Mice; Mites; Myeloma Proteins; Phosphorylcholine; Polysaccharides | 1977 |
A study on the possible occurrence of base-exchange reactions in vivo.
Topics: Animals; Brain; Choline; Ethanolamines; Female; Kinetics; Male; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine; Rats | 1978 |
[Effect of CDP-choline on GH release in patients with chronic psychopathy].
Topics: Adult; Choline; Chronic Disease; Depression; Female; Growth Hormone; Humans; Male; Mental Disorders; Middle Aged; Phosphorylcholine; Schizophrenia | 1978 |
A rapid method for the determination of CTP and phosphocholine in rat liver and baby hamster kidney 21 cells.
Topics: Cell Line; Choline; Cytidine Triphosphate; Cytosine Nucleotides; Liver; Methods; Nucleotidyltransferases; Phosphorylcholine | 1978 |
Induction of alkaline phosphatase activity in HeLa cells by choline chloride.
Topics: Alkaline Phosphatase; Caffeine; Cell Count; Choline; HeLa Cells; Hot Temperature; Idoxuridine; Phosphorylcholine; Sodium Chloride; Theophylline | 1978 |
Clonal nature of the immune response to phosphocholine. VI. Molecular uniformity of a single idiotype among BALB/c mice.
Topics: Animals; Antibody Specificity; Choline; Clone Cells; Immunoglobulin G; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1978 |
Alteration of clonal profile. I. Effect of sublethal irradiation on the responses to phosphorylcholine in BALB/c mice.
Topics: Animals; Animals, Newborn; Antibody Formation; Antibody Specificity; Choline; Clone Cells; Dose-Response Relationship, Radiation; Gamma Rays; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Trinitrobenzenes | 1978 |
The role of phosphate esters in male fertility.
Topics: Choline; Fertility; Glycerylphosphorylcholine; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Male; Oligospermia; Phosphorylcholine; Semen; Vasectomy | 1978 |
On the immune precipitation of phosphorylcholine lipids with TEPC 15 mouse myeloma protein and with anti-lecithin sera from guinea pigs.
Topics: Animals; Antibody Formation; Binding Sites, Antibody; Chemical Precipitation; Choline; Guinea Pigs; Immunoglobulin A; Lysophosphatidylcholines; Mice; Mice, Inbred BALB C; Micelles; Myeloma Proteins; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Sphingomyelins | 1978 |
Free and choline assay.
Topics: Animals; Body Fluids; Brain Chemistry; Choline; Humans; Methods; Phosphorylcholine | 1978 |
[Phosphorylcholine and cell membranes].
Topics: Animals; Cell Membrane; Choline; Erythrocyte Membrane; Female; Male; Phosphorylcholine; Platelet Aggregation; Rabbits | 1978 |
Raised bispecific anti-p-azophenylphosphorylcholine antibodies reactive with nitroiodohydroxyphenylacetyl.
Topics: Adsorption; Animals; Antibodies; Antibody Specificity; Antibody-Producing Cells; Azo Compounds; Binding Sites, Antibody; Choline; Haptens; Hemolytic Plaque Technique; Immunization; Phosphorylcholine; Rabbits | 1976 |
Studies on immune responses to parasite antigens in mice. IV. Inhibition of an anti-DNP antibody response with the antigen, DNP-Ficoll containing phosphorylcholine.
Topics: Animals; Antibody Formation; Antigens; Choline; Depression, Chemical; Dinitrobenzenes; Ficoll; Hemolytic Plaque Technique; Immune Tolerance; Lysine; Mice; Mice, Inbred CBA; Phosphorylcholine; Spleen; Tyramine | 1976 |
An IgM Waldenström with specificity against phosphorylcholine.
Topics: Aged; Binding Sites; Calorimetry; Choline; Chromatography, Affinity; Dialysis; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin Fab Fragments; Immunoglobulin Fragments; Immunoglobulin M; Kinetics; Male; Myeloma Proteins; Phosphorylcholine; Protein Binding; Thermodynamics; Waldenstrom Macroglobulinemia | 1975 |
[Proceedings: Compounds bearing phosphorylcholine in Nippostrongylus brasiliensis: preparation and animal responses].
Topics: Ancylostomatoidea; Animals; Antigen-Antibody Reactions; Choline; Immune Sera; Immunization Schedule; Immunodiffusion; Nippostrongylus; Phosphorylcholine; Rabbits; Rats | 1975 |
[Role of phosphorylcholine group on inhibiting capacity of lecithin-cholesterol liposomes on streptolysin O].
Topics: Cholesterol; Choline; Liposomes; Phosphatidylcholines; Phospholipases; Phosphorylcholine; Streptolysins | 1975 |
Effect of "drugs for liver disease" on hepatotoxic action of carbon tetrachloride. II. Effect of protoporphyrin and phosphorylcholine on microsomal drug-metabolizing enzyme activities and the components in injuried liver.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride Poisoning; Choline; Cytochrome P-450 Enzyme System; Cytochromes; Ferrous Compounds; Lipase; Lipid Metabolism; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peroxides; Phospholipids; Phosphorylcholine; Porphyrins; Protoporphyrins; Rats | 1975 |
Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains.
Topics: Amino Acid Sequence; Animals; Binding Sites, Antibody; Biological Evolution; Choline; Humans; Immunoglobulin Heavy Chains; Immunoglobulin mu-Chains; Mice; Phosphorylcholine | 1976 |
Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites, Antibody; Choline; Genes; Immunoglobulin alpha-Chains; Immunoglobulin Heavy Chains; Mice; Molecular Weight; Myeloma Proteins; Phosphorylcholine | 1976 |
Variable region sequence of the light chain from a Waldenströms IgM with specificity for phosphorylcholine.
Topics: Amino Acid Sequence; Animals; Binding Sites; Choline; Humans; Immunoglobulin Light Chains; Immunoglobulin M; Mice; Myeloma Proteins; Phosphorylcholine; Protein Binding; Waldenstrom Macroglobulinemia | 1976 |
Genetic marker in the variable region of kappa chains of mouse anti-phosphorylcholine antibodies.
Topics: Animals; Antibodies; Binding Sites, Antibody; Choline; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Immunoglobulin M; Immunoglobulin Variable Region; Isoelectric Focusing; Mice; Mice, Inbred Strains; Molecular Biology; Myeloma Proteins; Phenotype; Phosphorylcholine | 1976 |
Structural basis for the specificity of phosphorylcholine-binding immunoglobulins.
Topics: Amino Acid Sequence; Antibody Specificity; Binding Sites, Antibody; Choline; Haptens; Immunoglobulin Heavy Chains; Phosphorylcholine; Protein Conformation | 1976 |
Phosphatidylcholine biosynthesis and choline transport in the anaerobic protozoon Entodinium caudatum.
Topics: Calcium; Choline; Choline Kinase; Ciliophora; Hemicholinium 3; Phosphatidylcholines; Phosphorylcholine; Subcellular Fractions | 1976 |
Constant rate infusion of deuterated phosphorylcholine to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain.
Topics: Acetylcholine; Amygdala; Animals; Brain; Cerebral Cortex; Choline; Hippocampus; Kinetics; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Olfactory Bulb; Phosphorylcholine; Rats; Substantia Nigra; Time Factors | 1977 |
Preparation of phosphorylcholine from phosphorylcholine chloride calcium salt.
Topics: Cation Exchange Resins; Choline; Chromatography, Thin Layer; Phosphorylcholine | 1977 |
Effect of "drugs for liver disease" on hepatotoxic action of carbon tetrachloride. IV. Relationship between fatty acid composition of phospholipids and drug monooxygenation activity in rat liver microsomes and role of phosphorylcholine.
Topics: Aminopyrine; Animals; Carbon Tetrachloride Poisoning; Chemical Phenomena; Chemistry; Choline; Dealkylation; Electron Transport; Fatty Acids; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Rats | 1977 |
Stimulation of CDP-choline biosynthesis by enantiomeric lysophosphatidylcholines in rat intestinal mucosa.
Topics: Animals; Choline; Columbidae; Cytidine Diphosphate Choline; Cytosol; Fatty Acids; Intestinal Mucosa; Liver; Lysophosphatidylcholines; Male; Nucleotidyltransferases; Phospholipases; Phospholipids; Phosphorylcholine; Rats; Stereoisomerism | 1977 |
C-reative protein in the rabbit: isolation, characterization and binding affinity to phosphocholine.
Topics: Amino Acids; Animals; C-Reactive Protein; Choline; Chromatography, Affinity; Molecular Weight; Phosphorylcholine; Protein Binding; Rabbits | 1977 |
[Treatment of vitamin B 12 deficiency].
Topics: Arginine; Aspartic Acid; Choline; Drug Combinations; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intramuscular; Malates; Phosphorylcholine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamin B Deficiency | 1977 |
Naming the enzyme which splits the substrate phosphorylcholine, PC.
Topics: Acid Phosphatase; Animals; Choline; Epididymis; Male; Phosphorylcholine; Prostate; Rats; Substrate Specificity | 1977 |
Describing enzymatic hydrolysis of phosphorylcholine and D-ephedrine-o-phosphate.
Topics: Acid Phosphatase; Animals; Choline; Ephedrine; Male; Organ Specificity; Organophosphorus Compounds; Phosphorylcholine; Prostate; Substrate Specificity | 1977 |
Immune response to phosphorylcholine. III. Requirement of the Fc portion and equal effectiveness of IgG subclasses in anti-receptor antibody-induced suppression.
Topics: Animals; Antibodies; Antibody Formation; Binding Sites, Antibody; Binding, Competitive; Choline; Electrophoresis, Polyacrylamide Gel; Female; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunoglobulin G; Immunosuppression Therapy; Mice; Mice, Inbred A; Mice, Inbred BALB C; Phosphorylcholine | 1977 |
Effect of choline, phosphorylcholine and dimethylaminoethanol on brain acetylcholine level in the rat.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain Chemistry; Choline; Deanol; Ethanolamines; Hemicholinium 3; Injections, Intraventricular; Male; Phosphorylcholine; Rats; Time Factors | 1977 |
Immune response to phosphorylcholine II, natural "auto"-anti-receptor antibody in neonatal Balb/c mice.
Topics: Age Factors; Animals; Antibodies; Antigen-Antibody Reactions; Antigens; Binding Sites, Antibody; Choline; Female; Lymphocytes; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1976 |
Effect of "drugs for liver disease" on hepatotoxic action of carbon tetrachloride. III. Effect of protoporphyrin and phosphoryl-choline on injured microsomal membrane.
Topics: Animals; Carbon Tetrachloride Poisoning; Choline; In Vitro Techniques; Male; Membranes; Microsomes, Liver; Phosphorylcholine; Porphyrins; Protoporphyrins; Rats | 1976 |
The cytochemical demonstration of prostatic acid phosphatase using a new substrate, phosphorylcholine.
Topics: Acid Phosphatase; Animals; Choline; Epithelial Cells; Epithelium; Histocytochemistry; Male; Microscopy, Electron; Phosphorylcholine; Prostate; Rats | 1976 |
Carbon-13 nuclear magnetic resonance spectroscopy of suspensions of chinese hamster ovary cells specifically enriched with (methyl-13C)choline.
Topics: Animals; Carbon Isotopes; Cell Line; Choline; Cricetinae; Female; Formaldehyde; Magnetic Resonance Spectroscopy; Membrane Lipids; Ovary; Phospholipids; Phosphorylcholine; Ultrasonics | 1976 |
Fine specificity of rabbit anti-p-azophenylphosphorylcholine antibodies; comparison with HOPC-8 myeloma protein.
Topics: Antibody Specificity; Antigens; Azo Compounds; Binding Sites, Antibody; Choline; Cross Reactions; Haptens; Myeloma Proteins; Phosphorylcholine | 1976 |
Pool sizes and metabolism of CDPCholine and CDPethanolamine in skeletal muscle.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Cytosine Nucleotides; Ethanolamines; Liver; Male; Muscles; Phosphates; Phosphorylcholine; Rats | 1976 |
Synthesis of choline from ethanolamine in rat brain.
Topics: Acetylcholine; Animals; Brain; Choline; Ethanolamines; Liver; Male; Methionine; Models, Biological; Muscles; Phosphatidylcholines; Phosphorylcholine; Rats | 1976 |
Detection of anti-idiotype reactive cells in the response to phosphorylcholine.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibody Formation; Choline; Female; Immunoglobulin Allotypes; Kinetics; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1976 |
Antibody response to phosphorylcholine in vitro. I. Studies on the frequency of precursor cells, average clone size and cellular cooperation.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Antigens, Bacterial; Antilymphocyte Serum; Binding Sites, Antibody; Cell Adhesion; Choline; Clone Cells; Immunoglobulin Allotypes; Isoantigens; Kinetics; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine; Polysaccharides, Bacterial; Spleen; T-Lymphocytes | 1975 |
An em study of phosphorylcholine-binding fab immunoglobulin fragment crystals.
Topics: Animals; Choline; Crystallization; Immunoglobulin Fab Fragments; Mice; Microscopy, Electron; Models, Molecular; Phosphorylcholine; Protein Binding; Protein Conformation; X-Ray Diffraction | 1975 |
The release in vivo of [3-H] acetylcholine from cat caudate nucleus and cerebral cortex by atropine, pentylenetetrazol, K-+ -depolarization and electrical stimulation.
Topics: Acetylcholine; Animals; Atropine; Carbon Radioisotopes; Cats; Caudate Nucleus; Cerebellar Cortex; Cerebral Cortex; Choline; Electric Stimulation; Female; Lipid Metabolism; Male; Pentylenetetrazole; Phosphorylcholine; Potassium; Tritium; Urea | 1975 |
Incorporation of CDP-choline (methyl-14C) into lecithin or adult rat liver mitochondria and microsomes.
Topics: Animals; Choline; Microsomes; Phosphatidylcholines; Phosphorylcholine; Rats | 1975 |
[The influence of nicotinic acid and proserine on the process of methylation of several biological substrates].
Topics: Alcohol Oxidoreductases; Animals; Brain; Choline; Depression, Chemical; Liver; Methylation; Muscles; Neostigmine; Nicotinic Acids; Phospholipids; Phosphorylcholine; Rats | 1976 |
A phosphorylcholine idiotype related to TEPC 15 in mice infected with Ascaris suum.
Topics: Animals; Antibodies; Antibody Specificity; Ascaris; Choline; Female; Hemagglutinins; Immunoglobulin M; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloma Proteins; Phosphorylcholine | 1976 |
Evidence for a membrane defect in Alzheimer disease brain.
Topics: Aged; Alzheimer Disease; Brain; Brain Chemistry; Choline; Down Syndrome; Glycerylphosphorylcholine; Humans; Huntington Disease; Membrane Lipids; Middle Aged; Parkinson Disease; Phospholipids; Phosphoric Diester Hydrolases; Phosphorylcholine | 1992 |
Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.
Topics: Animals; Biological Transport; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Diglycerides; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate | 1992 |
The effects of noradrenaline and adenosine 5'-triphosphate on polyphosphoinositide and phosphatidylcholine hydrolysis in arterial smooth muscle.
Topics: Adenosine Triphosphate; Animals; Choline; Dose-Response Relationship, Drug; Hydrolysis; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Phosphatidylcholines; Phosphatidylinositols; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains; Time Factors; Tritium | 1992 |
Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained activ
Topics: Animals; Carbachol; Cell Line; Choline; Cricetinae; Cricetulus; Diglycerides; Growth Substances; Humans; Hydrolysis; Kinetics; Ligands; Phorbol 12,13-Dibutyrate; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Muscarinic; Recombinant Proteins; Signal Transduction; Thrombin; Transfection; Type C Phospholipases | 1992 |
Phosphatidylcholine metabolism in ischemic and hypoxic hearts.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Hypoxia; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Cricetinae; Cytidine Diphosphate Choline; Cytidine Triphosphate; Mesocricetus; Myocardial Ischemia; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine | 1992 |
Investigation of the mechanism of the effect of tacrine (tetrahydroaminoacridine) on the metabolism of acetylcholine and choline in brain cortical prisms.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Cerebral Cortex; Choline; Hemicholinium 3; In Vitro Techniques; Male; Nerve Endings; Paraoxon; Phosphatidylcholines; Phosphorylation; Phosphorylcholine; Rats; Rats, Wistar; Tacrine | 1992 |
IFN-gamma induces a phospholipase D dependent triphasic activation of protein kinase C in endothelial cells.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Choline; Diglycerides; Endothelium; Enzyme Activation; Glycerol; Inositol 1,4,5-Trisphosphate; Interferon-gamma; Kinetics; Myocardium; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phospholipase D; Phosphorylcholine; Protein Binding; Protein Kinase C; Rats; Recombinant Proteins; Tritium | 1992 |
Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13C-NMR studies of choline and ethanolamine uptake.
Topics: Breast Neoplasms; Cell Division; Choline; Ethanolamine; Ethanolamines; Humans; Magnetic Resonance Spectroscopy; Mathematics; Phosphorylcholine; Tumor Cells, Cultured | 1992 |
Measurement of the T2 relaxation time of ethanol and cerebral metabolites, in vivo.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Ethanol; Magnetic Resonance Spectroscopy; Phosphocreatine; Phosphorylcholine; Rats; Rats, Inbred Strains | 1992 |
Effect of osmotic stress on phosphorylcholine efflux and turnover in rat lenses.
Topics: Animals; Choline; Fluorenes; Galactose; Glucose; Hydantoins; Lens, Crystalline; Organ Culture Techniques; Osmotic Pressure; Phospholipids; Phosphorylcholine; Rats; Rats, Inbred Strains; Xylose | 1992 |
Effects of cholinergic agents on the metabolism of choline in muscle from Ascaris suum.
Topics: Acetylcholine; Animals; Ascaris; Carbachol; Choline; Cytidine Diphosphate Choline; Female; Glycerylphosphorylcholine; Levamisole; Muscles; Phosphatidylcholines; Phosphorylcholine | 1992 |
Osmoprotectants and phosphate regulate expression of phospholipase C in Pseudomonas aeruginosa.
Topics: Blotting, Northern; Choline; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Phosphates; Phosphorylcholine; Pseudomonas aeruginosa; RNA, Messenger; Type C Phospholipases; Water-Electrolyte Balance | 1992 |
Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipases D and C in rat tail artery.
Topics: Animals; Arteries; Cell Membrane; Choline; Ethanol; Kinetics; Male; Membrane Lipids; Muscle, Smooth, Vascular; Norepinephrine; Phosphatidylcholines; Phospholipase D; Phospholipids; Phosphorylcholine; Propranolol; Rats; Rats, Inbred Strains; Tail; Type C Phospholipases | 1992 |
Modulation of human lymphoblastoid B cell line by phorbol ester and sphingosine. A 31P-NMR study.
Topics: B-Lymphocytes; Cell Division; Cell Line, Transformed; Choline; Energy Metabolism; Enzyme Activation; Herpesvirus 4, Human; Humans; Magnetic Resonance Spectroscopy; Phorbol 12,13-Dibutyrate; Phospholipids; Phosphorylcholine; Protein Kinase C; Sphingosine | 1991 |
Lipid metabolism in T47D human breast cancer cells: 31P and 13C-NMR studies of choline and ethanolamine uptake.
Topics: Breast Neoplasms; Choline; Choline-Phosphate Cytidylyltransferase; Ethanolamine; Ethanolamines; Glycerylphosphorylcholine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Nucleotidyltransferases; Phosphorylcholine; RNA Nucleotidyltransferases; Tumor Cells, Cultured | 1991 |
[4-Tesla 1H MR spectroscopy in patients with temporal lobe epilepsy].
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Partial; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Glutamates; Glutamic Acid; Humans; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Phosphorylcholine; Reference Values; Temporal Lobe | 1991 |
Interactions of myelin basic protein with mixed dodecylphosphocholine/palmitoyllysophosphatidic acid micelles.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Choline; Circular Dichroism; Colloids; Detergents; Humans; Lysophospholipids; Magnetic Resonance Spectroscopy; Micelles; Myelin Basic Protein; Phosphorylcholine; Protein Conformation | 1990 |
Choline derivatives increase two different acid phosphatases in Rhizobium meliloti and Pseudomonas aeruginosa.
Topics: Acid Phosphatase; Atropine; Betaine; Choline; Culture Media; Phosphorylcholine; Pseudomonas aeruginosa; Quaternary Ammonium Compounds; Rhizobium; Sarcosine | 1990 |
Characterization of Trichinella spiralis antigens sharing an immunodominant, carbohydrate-associated determinant distinct from phosphorylcholine.
Topics: Amidohydrolases; Animals; Antibodies, Helminth; Antibodies, Monoclonal; Antigens, Helminth; Binding, Competitive; Choline; Electrophoresis, Gel, Two-Dimensional; Epitopes; Glycosylation; Immunoblotting; Oligosaccharides; Oxidation-Reduction; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Phosphorylcholine; Trichinella | 1990 |
Ethanol is a potent stimulator of phosphatidylcholine breakdown in cultured rat hepatocytes.
Topics: Adenosine Triphosphate; Alcohols; Animals; Calcimycin; Cells, Cultured; Choline; Ethanol; Inositol Phosphates; Liver; Norepinephrine; Phosphatidylcholines; Phospholipases; Phosphorylcholine; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 1992 |
Uptake and metabolism of choline by rat brain after acute choline administration.
Topics: Animals; Arteries; Brain; Buffers; Cerebrospinal Fluid; Choline; Dose-Response Relationship, Drug; Homeostasis; Kinetics; Male; Osmolar Concentration; Phosphorylcholine; Rats; Rats, Inbred Strains; Time Factors; Veins | 1992 |
Why do phospholipid levels decrease with repeated stimulation? A study of choline-containing compounds in rat striatum following electrical stimulation.
Topics: Acetylcholine; Animals; Choline; Corpus Striatum; Electric Stimulation; Glycerylphosphorylcholine; Phospholipids; Phosphorylcholine; Rats | 1991 |
The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
Topics: Animals; Cell Line; Choline; Dogs; Kinetics; N-Acylneuraminate Cytidylyltransferase; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine | 1991 |
Epidermal growth factor stimulates phospholipase D activity in the absence of inositol lipid hydrolysis in Swiss 3T3 cells.
Topics: Animals; Cell Line; Choline; Epidermal Growth Factor; Hydrolysis; Inositol Phosphates; Kinetics; Mice; Palmitic Acid; Palmitic Acids; Phospholipase D; Phosphorylcholine; Tritium | 1991 |
Quantitative analysis of water-soluble products of cell-associated phospholipase C- and phospholipase D-catalyzed hydrolysis of phosphatidylcholine.
Topics: Adenosine Triphosphate; Animals; Cells; Choline; Indicators and Reagents; Phosphatidylcholines; Phospholipase D; Phosphorus Radioisotopes; Phosphorylcholine; Solubility; Tritium; Type C Phospholipases; Water | 1991 |
Metabolites in the developing rat liver--a proton nuclear magnetic resonance spectroscopic study.
Topics: Animals; Animals, Newborn; Betaine; Choline; Female; Glycerylphosphorylcholine; Lactates; Lactic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Phosphorylcholine; Rats; Rats, Inbred Strains; Taurine; Tissue Extracts; Weaning | 1991 |
Isolation and enzymic assay of choline and phosphocholine present in cell extracts with picomole sensitivity.
Topics: Animals; Choline; Ethanolamine; Ethanolamines; Humans; Mast Cells; Neutrophils; Phosphorylcholine; Rats; Serine; Sodium Chloride; Solubility | 1990 |
Phosphocholine-containing antigens of Brugia malayi nonspecifically suppress lymphocyte function.
Topics: Adult; Animals; Antigens, Helminth; Brugia; Choline; Dose-Response Relationship, Immunologic; Elephantiasis, Filarial; Filariasis; Humans; Immune Tolerance; Immunity, Cellular; Lymphocyte Activation; Phosphorylcholine; T-Lymphocytes; T-Lymphocytes, Regulatory | 1990 |
Phosphatidylcholine metabolism for energy production in sea urchin spermatozoa.
Topics: Animals; Cell-Free System; Choline; Energy Metabolism; Fatty Acids, Nonesterified; Glycerylphosphorylcholine; Lysophosphatidylcholines; Male; Oleic Acid; Oleic Acids; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A; Phosphorylcholine; Sea Urchins; Spermatozoa | 1990 |
Epithelium-derived inhibition of [3H]acetylcholine release from the isolated guinea-pig trachea.
Topics: Acetylcholine; Animals; Choline; Chromatography, High Pressure Liquid; Electric Stimulation; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Models, Biological; Phosphorylcholine; Tetrodotoxin; Trachea; Veratridine | 1990 |
A thymus-independent (type 1) phosphorylcholine antigen isolated from Trichinella spiralis protects mice against pneumococcal infection.
Topics: Animals; Antibodies, Helminth; Antigens, Helminth; Choline; Immunization; Mice; Mice, Inbred CBA; Phosphorylcholine; Pneumococcal Infections; Species Specificity; Trichinella | 1990 |
Fine specificity and isotype expression of anti-PC antibodies in BALB/c, MRL/Mp-lpr/lpr, and -(+)/+ mice at different ages.
Topics: Age Factors; Animals; Autoimmune Diseases; Choline; Female; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin Isotypes; Immunoglobulin M; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Phosphorylcholine; Streptococcus pneumoniae | 1990 |
Interaction between rat serum phosphorylcholine binding protein and platelet activating factor.
Topics: Animals; Carrier Proteins; Choline; Chromatography, Gel; Chromatography, High Pressure Liquid; Phosphorylcholine; Platelet Activating Factor; Protein Binding; Rats; Rats, Inbred Strains | 1990 |
Quantitation of hexadecylphosphocholine by high-performance thin-layer chromatography with densitometry.
Topics: Choline; Chromatography, Thin Layer; Densitometry; Humans; Lipids; Phosphorylcholine | 1990 |
Changes in red blood cell choline and choline-bound lipids with oral lithium.
Topics: Administration, Oral; Adult; Choline; Erythrocytes; Glycerylphosphorylcholine; Humans; Lipids; Lithium; Middle Aged; Phosphatidylcholines; Phosphorylcholine | 1990 |
Studies on the activity of phospholipase D with alkyl phosphorylcholines.
Topics: Animals; Choline; Hydrolysis; Kinetics; Phospholipase D; Phospholipases; Phosphorylcholine; Substrate Specificity; Swine | 1990 |
High anti-phosphorylcholine antibody levels and mortality associated with pneumonia.
Topics: Age Factors; Aged; Antibodies; Choline; Female; Humans; Male; Phosphorylcholine; Pneumonia; Probability; Risk Factors; Sex Factors; Smoking; Time Factors | 1990 |
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.
Topics: Animals; Cell Division; Cell Line; Choline; Gangliosides; Kinetics; Lipid Metabolism; Mice; Neuroblastoma; Phospholipids; Phosphorylcholine; Psychosine; Sphingosine; Tumor Cells, Cultured | 1990 |
Fine specificity and heavy chain V gene usage of antibodies to the phosphorylcholine hapten.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; Blotting, Southern; Choline; Genes, Immunoglobulin; Hemocyanins; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1990 |
Evaluation by reverse phase HPLC of [3H]acetylcholine release evoked from the myenteric plexus of the rat.
Topics: Acetylcholine; Animals; Choline; Chromatography, High Pressure Liquid; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Oxotremorine; Phosphorylcholine; Rats; Receptors, Muscarinic; Scopolamine; Tetrodotoxin | 1990 |
Binding and immunological properties of a synthetic peptide corresponding to the phosphorylcholine-binding region of C-reactive protein.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Binding, Competitive; C-Reactive Protein; Choline; Humans; Immunoglobulin Idiotypes; In Vitro Techniques; Molecular Sequence Data; Peptides; Phosphorylcholine; Solubility | 1990 |
A rat brain cytosolic N-methyltransferase(s) activity converting phosphorylethanolamine into phosphorylcholine.
Topics: Animals; Brain; Cell Fractionation; Choline; Cytosol; Ethanolamines; Kinetics; Male; Methyltransferases; Phosphorylcholine; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Subcellular Fractions | 1990 |
T15-specific helper T cells: analysis of idiotype specificity by competitive inhibition analysis.
Topics: Animals; Antibody Formation; Antigens, Ly; Binding, Competitive; Cell Adhesion; Choline; Epitopes; Haptens; Hemolytic Plaque Technique; Immunoglobulin Idiotypes; Lymphocyte Cooperation; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1985 |
Effects of phosphorylcholine-lipopolysaccharide conjugates on the induction of anti-idiotype-mediated B-cell tolerance.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Choline; Dose-Response Relationship, Immunologic; Epitopes; Immune Tolerance; Immunoglobulin Idiotypes; Kinetics; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylcholine; Spleen | 1985 |
Antigen-specific T cell suppressor factor (TsF): isolation of a cDNA clone encoding for a functional polypeptide chain of phosphorylcholine-specific TsF.
Topics: Animals; Base Sequence; Cell Separation; Choline; DNA; Epitopes; Hybridomas; Mice; Mice, Inbred BALB C; Nucleic Acid Hybridization; Oocytes; Peptide Fragments; Phosphorylcholine; Protein Biosynthesis; RNA, Messenger; Suppressor Factors, Immunologic; T-Lymphocytes; Xenopus | 1985 |
Immunoresponses to Neisseria meningitidis epitopes: suppression of secondary response to phosphorylcholine is carrier specific.
Topics: Animals; Antigens, Bacterial; Carrier Proteins; Choline; Epitopes; Hemocyanins; Hemolytic Plaque Technique; Immune Tolerance; Immunologic Memory; Mice; Neisseria meningitidis; Phosphorylcholine | 1986 |
A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.
Topics: Aging; Animals; Antibodies, Monoclonal; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Choline; Epitopes; Mice; Mice, Inbred BALB C; Phenotype; Phosphorylcholine; Receptors, Antigen, B-Cell; Spleen; Stem Cells | 1986 |
Dipetalonema viteae: phosphorylcholine and non-phosphorylcholine antigenic determinants in infective larvae and adult worms.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antibody Specificity; Antigens, Helminth; Choline; Cross Reactions; Dipetalonema; Epitopes; Female; Immune Sera; Larva; Male; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1986 |
Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
Topics: Animals; Choline; DNA; Gene Expression Regulation; Immunoglobulin Heavy Chains; Immunoglobulin kappa-Chains; Immunoglobulin mu-Chains; Mice; Myeloma Proteins; Nucleic Acid Hybridization; Organ Specificity; Phosphorylcholine; Recombination, Genetic; RNA; Spleen; T-Lymphocytes | 1986 |
Expression of a recombinant murine IgE in transfected myeloma cells.
Topics: Animals; Antibody Specificity; Cell Line; Choline; Histamine Release; Immunoglobulin E; Immunoglobulin epsilon-Chains; Immunoglobulin Heavy Chains; Immunoglobulin kappa-Chains; Mice; Phosphorylcholine; Plasmacytoma; Recombinant Proteins; Transfection | 1987 |
Phosphorylcholine-bearing antigens in filarial nematode parasites: analysis of somatic extracts, in-vitro secretions and infection sera from Brugia malayi and B. pahangi.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Antigens, Helminth; Brugia; Choline; Chromatography, Gel; Cross Reactions; Electrophoresis, Polyacrylamide Gel; Elephantiasis, Filarial; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Gerbillinae; Haptens; Male; Phosphorylcholine; Radioimmunoassay | 1987 |
Immune response to Trichinella epitopes: the antiphosphorylcholine plaque-forming cell response during the biological cycle.
Topics: Animals; Antibody Formation; Antigens, Helminth; Choline; Epitopes; Female; Hemolytic Plaque Technique; Immunodiffusion; Immunoelectrophoresis; Mebendazole; Mice; Mice, Inbred BALB C; Phosphorylcholine; Trichinella; Trichinellosis | 1987 |
Serologic and molecular characterization of the T15 idiotype--II. Structural basis of independent idiotope expression on phosphorylcholine-specific monoclonal antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Line; Chemical Phenomena; Chemistry; Choline; Cross Reactions; Epitopes; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1987 |
Modulation of the anti-phosphorylcholine immune response during Trichinella spiralis infections in mice.
Topics: Animals; Antibody Formation; Antigens, Helminth; Choline; Epitopes; Erythrocytes; Hemolytic Plaque Technique; Larva; Mice; Phosphorylcholine; Rats; Rats, Inbred Strains; Sheep; Trichinella; Trichinellosis | 1987 |
Immunoresponses to Neisseria meningitidis epitopes: in vivo analysis of immunocompetent cells involved in suppression of secondary response to phosphorylcholine.
Topics: Animals; Antibody-Producing Cells; Antigens, Bacterial; B-Lymphocytes; Choline; Epitopes; Female; Hemolytic Plaque Technique; Immune Tolerance; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neisseria meningitidis; Phosphorylcholine; T-Lymphocytes | 1987 |
Identification of phosphorylcholine epitope-containing antigens in Brugia malayi and relation of serum epitope levels to infection status of jirds with brugian filariasis.
Topics: Animals; Antibodies, Monoclonal; Antigens, Helminth; Brugia; Choline; Electrophoresis, Polyacrylamide Gel; Elephantiasis, Filarial; Epitopes; Female; Filariasis; Gerbillinae; Immunoenzyme Techniques; Male; Microfilariae; Onchocerca; Phosphorylcholine; Radioimmunoassay | 1988 |
Characterization of dodecylphosphocholine/myelin basic protein complexes.
Topics: Animals; Brain; Cattle; Choline; Electron Spin Resonance Spectroscopy; Kinetics; Light; Magnetic Resonance Spectroscopy; Micelles; Microscopy, Electron; Myelin Basic Protein; Phosphorylcholine; Protein Binding; Scattering, Radiation; Swine; Ultracentrifugation | 1988 |
Identification and surface phenotypic characterization of phosphorylcholine-specific idiotype-bearing T cells.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Choline; Epitopes; Female; Immunoglobulin Idiotypes; Lymph Nodes; Mice; Mice, Inbred BALB C; Peptide Hydrolases; Phenotype; Phosphorylcholine; T-Lymphocytes | 1988 |
Characterization of an inbred mouse exhibiting low responsiveness to phosphorylcholine. Antibodies from low-responder mice suggest gene conversion events within the S107VH gene family.
Topics: Amino Acid Sequence; Animals; Antibody Formation; B-Lymphocytes; Base Sequence; Choline; Epitopes; Gene Conversion; Hybridomas; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Molecular Sequence Data; Phosphorylcholine | 1988 |
Immunomodulation by Trichinella spiralis: primary versus secondary response to phosphorylcholine-containing antigens.
Topics: Animals; Antigens, Helminth; Choline; Epitopes; Lymphocytes; Mice; Mice, Inbred Strains; Mice, Nude; Phosphorylcholine; T-Lymphocytes; Trichinella; Trichinellosis | 1988 |
Binding of human C-reactive protein (CRP) to plasma fibronectin occurs via the phosphorylcholine-binding site.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Binding, Competitive; C-Reactive Protein; Calcium; Choline; Epitopes; Fibronectins; Humans; Immunoglobulin A; Immunoglobulin Fab Fragments; Immunoglobulin Idiotypes; Mice; Myeloma Proteins; Phosphorylcholine | 1988 |
Antibody combining site heterogeneity within the response to phosphocholine-keyhole limpet hemocyanin.
Topics: Animals; Antibodies, Monoclonal; Antibody Affinity; Binding Sites, Antibody; Choline; Epitopes; Hemocyanins; Mice; Phosphorylcholine | 1989 |
On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5.
Topics: Amino Acids; Antigen-Antibody Complex; Binding Sites, Antibody; Choline; Computer Graphics; Crystallography; Energy Transfer; Epitopes; Hydrogen Bonding; Mathematics; Models, Theoretical; Molecular Conformation; Muramidase; Phosphorylcholine; Thermodynamics | 1989 |
Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii.
Topics: Amino Acid Sequence; Animals; Antibodies, Bacterial; Antibody Affinity; Antibody Diversity; Antigens, Bacterial; Base Sequence; Blotting, Southern; Choline; Epitopes; Gene Rearrangement, B-Lymphocyte; Genes, Immunoglobulin; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylcholine; Protein Conformation; Proteus; Selection, Genetic | 1989 |
Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.
Topics: Aging; Animals; Antibody Specificity; Bone Marrow; Cells, Cultured; Choline; Clone Cells; Epitopes; Genes, Immunoglobulin; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Multigene Family; Phenotype; Phosphorylcholine; Receptors, Antigen, B-Cell; Stem Cells | 1989 |
Differential L chain expression in the antibody responses to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes.
Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Bone Marrow; Bone Marrow Transplantation; Choline; Immunoglobulin Light Chains; Mice; Mice, Inbred BALB C; Myeloma Proteins; Peritoneal Cavity; Phosphorylcholine | 1989 |
The effect of an aldose reductase inhibitor on lens phosphorylcholine under hyperglycemic conditions: biochemical and NMR studies.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Blood Glucose; Choline; Culture Media; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Galactose; Lens, Crystalline; Magnetic Resonance Spectroscopy; Male; Membrane Lipids; Organ Culture Techniques; Phosphorylcholine; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases; Xylose | 1989 |
Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
Topics: Animals; Antigens, Surface; B-Lymphocytes; Choline; Crosses, Genetic; Female; Flow Cytometry; Hemocyanins; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulin mu-Chains; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Phosphorylcholine; Spleen | 1989 |
Sequence and fine specificity analysis of primary 511 anti-phosphorylcholine antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Antibody Specificity; Base Sequence; Choline; Haptens; Hemocyanins; Hybridomas; Immunoglobulin Heavy Chains; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Phosphorylcholine | 1989 |
Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet hemocyanin.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Base Sequence; Choline; Hemocyanins; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Joining Region; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunoglobulin Variable Region; Immunologic Memory; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mollusca; Mutation; Phosphorylcholine | 1989 |
Collaboration of Th1 and Th2 T cell clones in specific antibody responses: regulation of the IgM response to phosphorylcholine.
Topics: Animals; Choline; Clone Cells; Dose-Response Relationship, Immunologic; Hemocyanins; Immunoglobulin M; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukins; Mice; Mice, Inbred C57BL; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1989 |
Restricted idiotypic profile of anti-phosphorylcholine antibodies induced by carrier-specific helper T cell clones.
Topics: Animals; Choline; Clone Cells; Hemocyanins; Immunoglobulin Idiotypes; Lymphocyte Activation; Lymphocyte Cooperation; Mice; Mice, Inbred C57BL; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1989 |
Regional and developmental estimations of glycerophosphorylcholine phosphodiesterase activities in rat brain.
Topics: Animals; Biomarkers; Brain; Choline; Myelin Sheath; Phosphoric Diester Hydrolases; Phosphorylcholine; Rats | 1989 |
Glycerophosphorylcholine phosphocholine phosphodiesterase activity of rat brain myelin.
Topics: Animals; Brain; Calcium; Choline; Glycerylphosphorylcholine; Myelin Sheath; Phosphoric Diester Hydrolases; Phosphorylcholine; Rats; Subcellular Fractions; Substrate Specificity; Zinc | 1989 |
Effect of hyperpnea on enzymes of the CDPcholine path for phosphatidylcholine synthesis in rat lung.
Topics: Animals; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Cytosol; Diacylglycerol Cholinephosphotransferase; Hyperventilation; Kinetics; Lung; Male; Microsomes; Nucleotidyltransferases; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Pulmonary Ventilation; Rats; Swimming; Tidal Volume | 1989 |
N-terminal half of a mitochondrial presequence peptide takes a helical conformation when bound to dodecylphosphocholine micelles: a proton nuclear magnetic resonance study.
Topics: Choline; Electron Transport Complex IV; Enzyme Precursors; Magnetic Resonance Spectroscopy; Micelles; Mitochondria; Models, Molecular; Phosphorylcholine; Protein Binding; Protein Conformation; Protein Sorting Signals | 1989 |
Induction of phosphatidylcholine biosynthesis via CDPcholine pathway in lung and liver of rats following intratracheal administration of DDT and endosulfan.
Topics: Animals; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DDT; Endosulfan; Intubation, Intratracheal; Lung; Male; Microsomes; Microsomes, Liver; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains; Scintillation Counting | 1989 |
Antigen-specific anti-phosphocholine antibodies: binding site studies.
Topics: Animals; Antibodies, Monoclonal; Antigens, Bacterial; Antigens, Fungal; Ascaris; Binding Sites, Antibody; Choline; Epitopes; Hybridomas; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Phosphorylcholine; Proteus | 1985 |
Immunoresponses to Neisseria meningitidis epitopes: primary versus secondary antiphosphorylcholine responses.
Topics: Animals; Antibodies, Bacterial; Choline; Epitopes; Female; Immunization; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Memory; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neisseria meningitidis; Phosphorylcholine; Polysaccharides, Bacterial | 1985 |
The circular dichroism of phosphocholine-specific mouse hybridoma and myeloma proteins: unusual properties of the hybridoma protein 101.6G6.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Antibody Specificity; Choline; Circular Dichroism; Epitopes; Haptens; Hybridomas; Immunoglobulin A; Immunoglobulin M; Mice; Myeloma Proteins; Phosphorylcholine | 1985 |
Phosphorylcholine and phosphorylethanolamine in human and rhesus monkey lenses.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Choline; Culture Techniques; Ethanolamines; Eye Banks; Humans; Infant; Infant, Newborn; Lens, Crystalline; Macaca mulatta; Middle Aged; Phosphorylcholine; Tissue Preservation | 1989 |
Metabolism of peripheral lymphocytes, interleukin-2-activated lymphocytes and tumor-infiltrating lymphocytes from 31P NMR studies.
Topics: Adenosine Triphosphate; Choline; Energy Metabolism; Ethanolamines; Humans; Interleukin-2; Killer Cells, Lymphokine-Activated; Lymphocyte Activation; Lymphocytes; Magnetic Resonance Spectroscopy; Phosphorylcholine | 1989 |
Impact of C-reactive protein (CRP) on surfactant function.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Choline; Enzyme-Linked Immunosorbent Assay; Humans; Iodine Radioisotopes; Liposomes; Phosphorylcholine; Pulmonary Surfactants; Respiratory Distress Syndrome; Surface Tension | 1989 |
Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism.
Topics: Bombesin; Cell Line; Choline; Chromatography, Ion Exchange; Fibroblasts; Glycerylphosphorylcholine; Kinetics; Phosphatidylcholines; Phosphorylcholine; Solubility; Tetradecanoylphorbol Acetate; Tritium; Water | 1989 |
An appraisal of the role of biliary phospholipases in the pathogenesis of gallstone disease.
Topics: Bile; Cholelithiasis; Cholesterol; Choline; Fatty Acids, Nonesterified; Humans; Kinetics; Phospholipase D; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Type C Phospholipases | 1989 |
Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
Topics: Animals; Antibody Formation; B-Lymphocytes; Choline; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, B-Lymphocyte, Light Chain; Genes, Immunoglobulin; Mice; Mice, Transgenic; Phosphorylcholine | 1989 |
Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.
Topics: Adolescent; Adult; Aged; Animals; Antibodies; Antigens; Blood; Choline; Diethylcarbamazine; Elephantiasis, Filarial; Female; Filariasis; Humans; Immunoglobulin G; Immunoglobulin M; Male; Microfilariae; Middle Aged; Phosphorylcholine; Wuchereria bancrofti | 1989 |
The binding of phosphorylcholine-carrying antigens to the anti-phosphorylcholine monoclonal antibody TEPC 15. A fluorescence spectroscopic study.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens; Binding Sites, Antibody; Choline; Fluorescent Antibody Technique; Haptens; Lipids; Phosphorylcholine; Protein Conformation; Spectrometry, Fluorescence; Tryptophan | 1989 |
Age-dependent changes of isotype and idiotype expression in the antibody response to the phosphorylcholine hapten in BALB/c mice.
Topics: Aging; Animals; Choline; Female; Haptens; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin Isotypes; Immunologic Memory; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1989 |
Synthesis and secretion of phospholipase C by oral spirochetes.
Topics: Choline; Humans; Hydrolysis; Periodontitis; Phosphorylcholine; Treponema; Type C Phospholipases | 1989 |
Activation of phospholipase D by the fucose-sulfate glycoconjugate that induces an acrosome reaction in spermatozoa.
Topics: Acrosome; Animals; Choline; Diglycerides; Enzyme Activation; Fucose; Glycoconjugates; Male; Phosphatidic Acids; Phosphorylation; Phosphorylcholine; Sea Urchins; Spermatozoa; Sulfates; Sulfuric Acids; Verapamil | 1989 |
Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Choline; Drug Screening Assays, Antitumor; Female; Humans; Liver; Mammary Neoplasms, Experimental; Mice; Neoplasm Recurrence, Local; Phosphorylcholine; Rats; Rats, Inbred Strains; Skin Neoplasms; Tumor Cells, Cultured | 1989 |
Regulation of idiotype expression. II. The phenotypic diversity of T15 idiotype-bearing antibody to phosphorylcholine in response to T-dependent and T-independent antigens.
Topics: Animals; Antigens; Antigens, T-Independent; Choline; Haptens; Hemocyanins; Horseshoe Crabs; Immune Sera; Immunization; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1989 |
Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates.
Topics: Animals; Cell Membrane Permeability; Choline; Cytidine Diphosphate Choline; Electricity; Models, Biological; Phosphatidylcholines; Phosphorylcholine; Rats; Tumor Cells, Cultured | 1989 |
Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine.
Topics: Choline; Chromatography, High Pressure Liquid; Diglycerides; Enzyme Activation; Glycerides; Humans; Hydrolysis; Neutrophils; Phosphorylcholine; Type C Phospholipases | 1989 |
Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin.
Topics: Animals; Calcium; Choline; Chromatography, Affinity; Erythrocytes; Hemolysis; Membrane Glycoproteins; Membrane Proteins; Perforin; Phospholipids; Phosphorylcholine; Pore Forming Cytotoxic Proteins; Protein Binding; Sheep; T-Lymphocytes, Cytotoxic | 1989 |
Non-enzymatic synthesis of the coenzymes, uridine diphosphate glucose and cytidine diphosphate choline, and other phosphorylated metabolic intermediates.
Topics: Choline; Cytidine Diphosphate Choline; Cytidine Triphosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Indicators and Reagents; Phosphoric Diester Hydrolases; Phosphorylcholine; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars | 1987 |
Simple, rapid enzymatic determination of glycerophosphocholine in human seminal plasma.
Topics: Alcohol Oxidoreductases; Catalase; Choline; Glycerylphosphorylcholine; Humans; Hydrolysis; Infertility, Male; Male; Phosphoric Diester Hydrolases; Phosphorylcholine; Semen; Spectrophotometry; Vasectomy | 1988 |
Adenosine inhibits choline kinase activity and decreases the phosphorylation of choline in striatal synaptosomes.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Choline; Choline Kinase; Corpus Striatum; Deoxyadenosines; Dideoxyadenosine; Kinetics; Male; Phosphorylation; Phosphorylcholine; Phosphotransferases; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Choline; Cytosol; Diglycerides; Endothelium, Vascular; Glycerides; Glycerylphosphorylcholine; Humans; Kinetics; Male; Microsomes; Phosphatidate Phosphatase; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Phospholipases; Phosphoric Monoester Hydrolases; Phosphorylcholine; Pulmonary Artery; Rats | 1988 |
Bradykinin stimulates phosphodiesteratic cleavage of phosphatidylcholine in cultured endothelial cells.
Topics: Animals; Bradykinin; Cattle; Cell Line; Choline; Cytidine Diphosphate Choline; Diglycerides; Endothelium, Vascular; Glycerol; Glycerylphosphorylcholine; Kinetics; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phosphatidylcholines; Phosphoric Diester Hydrolases; Phosphorylcholine; Pulmonary Artery | 1988 |
Intracellular processing of cytidylyltransferase in Krebs II cells during stimulation of phosphatidylcholine synthesis. Evidence that a plasma membrane modification promotes enzyme translocation specifically to the endoplasmic reticulum.
Topics: 5'-Nucleotidase; Animals; Biological Transport; Cell Fractionation; Cell Membrane; Centrifugation; Centrifugation, Density Gradient; Choline; Choline-Phosphate Cytidylyltransferase; Clostridium perfringens; Concanavalin A; Cytosol; Endoplasmic Reticulum; Enzyme Activation; Hydrogen-Ion Concentration; Mice; Nucleotidases; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Type C Phospholipases; Uridine | 1988 |
Age-related change in anti-carbohydrate antibody levels.
Topics: ABO Blood-Group System; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Choline; Female; Humans; Immunoglobulin M; Isoantibodies; Longitudinal Studies; Male; Middle Aged; Phosphorylcholine | 1989 |
1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity?
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diglycerides; Enzyme Activation; Glycerides; Liver; Liver Neoplasms; Male; Phosphorylcholine; Protein Kinase C; Rats; Rats, Inbred Strains | 1989 |
Transport and phosphorylation of choline in higher plant cells. Phosphorus-31 nuclear magnetic resonance studies.
Topics: Biological Transport; Cells; Choline; Choline Kinase; Cytosol; Eukaryotic Cells; Iodine Radioisotopes; Magnetic Resonance Spectroscopy; Phosphates; Phosphorus; Phosphorylation; Phosphorylcholine; Protoplasts; Trees | 1989 |
Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.
Topics: Aging; Animals; Antibody Formation; Antigens; B-Lymphocytes; Choline; Female; Hemolytic Plaque Technique; Immunization, Passive; Immunocompetence; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred Strains; Phosphorylcholine; Spleen; T-Lymphocytes, Regulatory | 1986 |
Regulation of T15 idiotype dominance. III. Phosphocholine-specific B-cell activation in vivo requires major histocompatibility complex-restricted T-cell help.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Antigens, Surface; B-Lymphocytes; Cell Line; Choline; Immunoglobulin Idiotypes; Immunologic Memory; Lymphocyte Activation; Major Histocompatibility Complex; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1986 |
Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Choline; Erythrocytes; Hemolysis; Humans; Intracellular Membranes; Male; Mitochondria, Liver; Mitochondrial Swelling; Niemann-Pick Diseases; Oxygen Consumption; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains; Sphingosine | 1988 |
Regulation of phosphatidylcholine biosynthesis in Chinese hamster ovary cells by reversible membrane association of CTP: phosphocholine cytidylyltransferase.
Topics: Animals; Cell Line; Choline; Choline-Phosphate Cytidylyltransferase; Cricetinae; Cricetulus; Cycloheximide; Female; Nucleotidyltransferases; Ovary; Phosphatidylcholines; Phosphorylcholine; Type C Phospholipases | 1985 |
Simultaneous assay of choline kinase and choline oxidase in tissue by high-performance cation-exchange chromatography and continuous radioactive detection.
Topics: Alcohol Oxidoreductases; Animals; Anura; Cell Line; Chemical Phenomena; Chemistry; Choline; Choline Kinase; Chromatography, Ion Exchange; Phosphorylcholine; Phosphotransferases; Time Factors | 1985 |
31P nuclear magnetic resonance analysis of lung cancer: the perchloric acid extract spectrum.
Topics: Adenoviridae; Aged; Antibodies, Monoclonal; Cell Line; Cell Transformation, Neoplastic; Choline; Female; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Perchlorates; Phosphorylcholine | 1986 |
Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes.
Topics: Animals; Cell Line; Choline; Diglycerides; Glycerides; Glycerol; Insulin; Kinetics; Muscles; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate | 1988 |
The cross-reactive immune response between infective larvae and adult worms of Acanthocheilonema (Dipetalonema) viteae is dominated by phosphorylcholine.
Topics: Animals; Antibodies, Helminth; Antibody Specificity; Antigens, Helminth; Choline; Cross Reactions; Dipetalonema; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Larva; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1988 |
Hexadecylphosphocholine (D 18506) in the topical treatment of skin metastases: a phase-I trial.
Topics: Administration, Topical; Breast Neoplasms; Choline; Drug Evaluation; Female; Humans; Neoplasm Recurrence, Local; Phosphorylcholine; Skin Neoplasms | 1988 |
T15 idiotype expression in the murine response to phosphorylcholine is actively regulated by genes linked to the Igh-C locus.
Topics: Animals; Choline; Crosses, Genetic; Female; Genes; Genetic Linkage; Hemolytic Plaque Technique; Heterozygote; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin M; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Myeloma Proteins; Phosphorylcholine; Species Specificity; T-Lymphocytes | 1986 |
Immunologic memory to phosphorylcholine (PC). VIII. Expression of the VH-12 gene product in the response to PC-keyhole limpet hemocyanin.
Topics: Amino Acid Sequence; Animals; Antibody Formation; Choline; Female; Genes; Hemocyanins; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Immunologic Memory; Male; Mice; Nucleic Acid Hybridization; Phosphorylcholine | 1986 |
A novel idiotopic determinant on phosphorylcholine-binding immunoglobulins restricted to isotype and allotype.
Topics: Animals; Antibody Specificity; Choline; Immunoglobulin Allotypes; Immunoglobulin alpha-Chains; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred Strains; Phosphorylcholine | 1986 |
A comparative analysis of the anti-phosphorylcholine response of CLA and BALB/c mice.
Topics: Animals; Antibody Formation; Antibody Specificity; B-Lymphocytes; Choline; Hybridization, Genetic; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Muridae; Phosphorylcholine | 1986 |
Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A.
Topics: Amino Acid Sequence; Binding Sites, Antibody; Choline; Hydrogen Bonding; Immunoglobulin Fab Fragments; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Phosphorylcholine; Protein Conformation; X-Ray Diffraction | 1986 |
Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Antigens, Bacterial; Base Sequence; Choline; Genes; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Immunologic Memory; Mice; Mutation; Phosphorylcholine; Proteus; Time Factors | 1987 |
Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.
Topics: Animals; Autoantibodies; Base Sequence; Cell Line; Choline; DNA, Neoplasm; Genetic Variation; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Mice; Nucleic Acid Hybridization; Phosphorylcholine; Plasmacytoma | 1987 |
Induction of antiphosphocholine antibodies utilizing lambda light chains in BALB/c mice.
Topics: Adjuvants, Immunologic; Alum Compounds; Aluminum; Animals; Antibody Formation; Bentonite; Choline; Haptens; Hemocyanins; Immunoglobulin lambda-Chains; Kinetics; Mice; Mice, Inbred BALB C; Phosphorylcholine; Sulfates | 1987 |
[Anti-phosphorylcholine response of autoimmune NZB/W mice: variations with age of serum titers and homogeneity].
Topics: Aging; Animals; Antibody Affinity; Antigens, Bacterial; Choline; Female; Hemocyanins; Immune Sera; Mice; Mice, Inbred NZB; Neisseria meningitidis; Phosphorylcholine | 1987 |
Phosphorylcholine stimulates capsule formation of phosphate-limited mucoid Pseudomonas aeruginosa.
Topics: Alginates; Choline; Cystic Fibrosis; Extracellular Space; Glucuronic Acid; Hexuronic Acids; Microscopy, Electron; Models, Biological; Nitrogen; Phosphates; Phosphorylcholine; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Viscosity | 1988 |
Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Diversity; Base Sequence; Binding Sites, Antibody; Choline; Genes, Immunoglobulin; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin M; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Phosphorylcholine | 1988 |
Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine.
Topics: Amino Acid Sequence; Animals; Antibody Affinity; Antibody Diversity; Antibody Specificity; Base Sequence; Choline; Female; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Sequence Data; Mutation; Myeloma Proteins; Phosphorylcholine | 1988 |
Characterization of the antitumor activity of hexadecylphosphocholine (D 18506).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Choline; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Leukocytosis; Mammary Neoplasms, Experimental; Phosphorylcholine; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1988 |
Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae. Germ-line but not mutated T15 antibodies are dominantly selected.
Topics: Amino Acid Sequence; Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antibody Specificity; Base Sequence; Choline; Genes, Immunoglobulin; Germ Cells; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Molecular Sequence Data; Mutation; Myeloma Proteins; Phosphorylcholine; Streptococcus pneumoniae | 1988 |
Regulation of T15 idiotype dominance. II. Genes unlinked to the Igh locus regulate T15 dominance of the secondary adoptive transfer response to phosphocholine.
Topics: Alleles; Animals; B-Lymphocytes; Choline; Genes; Genes, Dominant; Genetic Linkage; Genotype; Immunization, Passive; Immunoglobulin Idiotypes; Immunologic Memory; Mice; Mice, Inbred Strains; Phosphorylcholine; Species Specificity; T-Lymphocytes; T-Lymphocytes, Helper-Inducer | 1985 |
Helper T cell requirements for T15 idiotype expression on phosphorylcholine-specific antibodies.
Topics: Animals; Antibody Formation; Antibody Specificity; B-Lymphocytes; Choline; Clone Cells; Hemocyanins; Immunoglobulin Idiotypes; Lymphocyte Cooperation; Mice; Mice, Inbred Strains; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1985 |
Age-dependent IgG subclass distribution of phosphocholine antibodies in humans.
Topics: Adult; Age Factors; Child, Preschool; Choline; Humans; Immunoglobulin G; Immunoglobulin Isotypes; Infant; Otitis; Phosphorylcholine | 1988 |
The interaction of an anti-phosphorylcholine monoclonal antibody with phosphorylcholine-containing lipids.
Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; Choline; Liposomes; Phosphorylcholine; Spectrometry, Fluorescence | 1988 |
Regulation of an idiotype+ B cell lymphoma. Effects of antigen and anti-idiotopic antibodies on proliferation and Ig secretion.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Line; Choline; Immunoglobulin Idiotypes; Immunosuppressive Agents; Interleukin-4; Interleukins; Lymphocyte Activation; Lymphoma; Mice; Myeloma Proteins; Phenotype; Phosphorylcholine; Polysaccharides, Bacterial; Receptors, Antigen, B-Cell; Transfection | 1988 |
The antiphosphorylcholine plaque-forming cell responses induced by the nematode Trichinella in BWF1 mice.
Topics: Age Factors; Animals; Autoantibodies; Choline; Female; Hemolytic Plaque Technique; Immune Tolerance; Larva; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine; Trichinella | 1987 |
Inhibition of self-binding antibodies (autobodies) by a VH-derived peptide.
Topics: Amino Acid Sequence; Autoantibodies; Choline; Immunoglobulin Idiotypes; Immunoglobulin Variable Region; Peptides; Phosphorylcholine; Protein Binding; Structure-Activity Relationship | 1988 |
Lipid-induced aggregation of phospholipase A2: sucrose density gradient ultracentrifugation and crosslinking studies.
Topics: Barium; Calcium; Centrifugation, Density Gradient; Choline; Cross-Linking Reagents; Elapid Venoms; Kinetics; Molecular Weight; Phosphatidylcholines; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine | 1988 |
Characterization of the group I and group II antibody response against PC-KLH in normal and T15 idiotype-suppressed BALB/c mice.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Formation; Choline; Female; Hemocyanins; Immune Tolerance; Immunoglobulin Idiotypes; Immunoglobulin Isotypes; Immunologic Memory; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1988 |
A newly characterized group of anti-phosphocholine antibodies: group III antibodies.
Topics: Antibodies, Monoclonal; Antigens, Bacterial; Binding, Competitive; Chemical Phenomena; Chemistry; Choline; Enzyme-Linked Immunosorbent Assay; Isoelectric Focusing; Phosphorylcholine; Streptococcus pneumoniae | 1988 |
New cytostatics with experimentally different toxic profiles.
Topics: Animals; Antineoplastic Agents; Choline; Dogs; Female; Male; Neoplasms, Experimental; Phospholipid Ethers; Phosphorylcholine; Rats | 1987 |
Distribution and metabolism of hexadecylphosphocholine in mice.
Topics: Administration, Oral; Animals; Choline; Female; Mice; Phosphorylcholine; Tissue Distribution | 1987 |
Therapeutic activity of ET-18-OCH3 and hexadecylphosphocholine against mammary tumors in BD-VI rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Choline; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Male; Mammary Neoplasms, Experimental; Phospholipid Ethers; Phosphorylcholine; Rats | 1987 |
Alkyl phosphocholines: toxicity and anticancer properties.
Topics: Animals; Antineoplastic Agents; Carcinoma; Choline; Dose-Response Relationship, Drug; Female; Male; Mammary Neoplasms, Experimental; Phospholipid Ethers; Phosphorylcholine; Rats; Rats, Inbred Strains; Sex Factors | 1987 |
Production and immunological characterization of a monoclonal antibody to Trichophyton quinckeanum: interaction with phosphorylcholine-bearing components.
Topics: Animals; Antibodies, Monoclonal; Antigens, Fungal; Bacterial Outer Membrane Proteins; Choline; Enzyme-Linked Immunosorbent Assay; Hybridomas; Mice; Mice, Inbred BALB C; Microscopy, Electron; Phosphorylcholine; Porins; Trichophyton | 1987 |
Antibody catalysis by transition state stabilization.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Catalysis; Cell Line; Choline; Drug Stability; Hydrolysis; Immunoglobulin A; Phosphorylcholine; Plasmacytoma | 1987 |
T15 dominance in BALB/c mice is not controlled by environmental factors.
Topics: Animals; B-Lymphocytes; Choline; Diet; Environment; Germ-Free Life; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Receptors, Antigen, B-Cell | 1986 |
In situ identification of idiotype-positive cells participating in the immune response to phosphorylcholine.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Formation; B-Lymphocytes; Choline; Female; Immunoglobulin Idiotypes; Lectins; Lymph Nodes; Mice; Peanut Agglutinin; Phosphorylcholine; Plasma Cells; Streptococcus pneumoniae | 1986 |
Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product.
Topics: Animals; Antibody Formation; B-Lymphocytes; Choline; Clone Cells; Gene Expression Regulation; Hybridomas; Isoelectric Focusing; Mice; Mice, Inbred BALB C; Phosphorylcholine; Viral Proteins | 1986 |
Human antibodies to phosphocholine. IgG anti-PC antibodies express restricted numbers of V and C regions.
Topics: Autoantibodies; Choline; Humans; Immunoglobulin Constant Regions; Immunoglobulin G; Immunoglobulin Variable Region; Isoelectric Focusing; Phosphorylcholine | 1987 |
Naturally occurring antibodies to phosphocholine as a potential index of antibody responsiveness to polysaccharides.
Topics: ABO Blood-Group System; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Antibodies, Bacterial; Child; Child, Preschool; Choline; Dysgammaglobulinemia; Humans; IgG Deficiency; Isoantibodies; Middle Aged; Phosphorylcholine; Polysaccharides, Bacterial; Streptococcus pneumoniae; Teichoic Acids; Wiskott-Aldrich Syndrome | 1987 |
Preparation of phosphorylcholine derivatives of bovine serum albumin and their application to the affinity chromatography of C-reactive protein.
Topics: C-Reactive Protein; Choline; Chromatography, Affinity; Humans; Molecular Weight; Phosphorylcholine; Serum Albumin, Bovine | 1987 |
Choline incorporation by Schistosoma mansoni: distribution of choline metabolites during development and after sexual differentiation.
Topics: Animals; Betaine; Carbon Radioisotopes; Choline; Cytidine Diphosphate Choline; Female; Male; Phosphatidylcholines; Phosphorylcholine; Schistosoma mansoni; Sex Differentiation | 1987 |
The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.
Topics: Alkylation; Animals; Choline; Leishmania donovani; Mice; Mice, Inbred BALB C; Phosphorylcholine; Structure-Activity Relationship | 1987 |
Cerebellar metabolism of phosphatidylcholine and its hydrosoluble precursors during bicuculline-induced convulsive seizures.
Topics: Animals; Bicuculline; Cerebellum; Choline; Female; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains; Seizures; Solubility; Time Factors | 1986 |
Biomembranes as models for polymer surfaces. II. The syntheses of reactive species for covalent coupling of phosphorylcholine to polymer surfaces.
Topics: Biocompatible Materials; Blood Cells; Cell Membrane; Choline; Humans; Membranes, Artificial; Phosphorylcholine; Polymers; Surface Properties; Thrombosis | 1986 |
Biomembranes as models for polymer surfaces. III. Characterization of a phosphorylcholine surface covalently bound to glass.
Topics: Biocompatible Materials; Blood Cells; Cell Membrane; Choline; Glass; Hemostasis; Humans; Membranes, Artificial; Phosphorylcholine; Polymers; Spectrophotometry, Infrared; Surface Properties | 1986 |
Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.
Topics: Aging; Animals; Choline; Crosses, Genetic; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylcholine; Polymorphism, Genetic; Species Specificity | 1986 |
Monoclonal phosphorylcholine antibody binds to beta-lipoprotein from different animal species.
Topics: Animals; Antibodies, Monoclonal; Autoantibodies; Binding, Competitive; Chickens; Choline; Cricetinae; Geese; Horses; Humans; Immunoelectrophoresis; Lipoproteins, LDL; Mice; Phosphorylcholine; Rabbits; Rats; Species Specificity; Swine | 1986 |
Fine specificity and idiotype expression of anti-phosphorylcholine IgE and IgG antibodies.
Topics: Animals; Antibody Specificity; Choline; Female; Hemocyanins; Immunoglobulin E; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Mice, Inbred Strains; Ovalbumin; Phosphorylcholine | 1986 |
Inhibition of pneumococcal autolysis in lysis-centrifugation blood culture.
Topics: Bacteriolysis; Blood; Choline; Culture Media; Humans; Phosphorylcholine; Streptococcus pneumoniae | 1986 |
Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Humans; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Phosphorylcholine | 1986 |
Antibodies to phosphorylcholine in sera of patients with humoral immunodeficiency disease.
Topics: Adolescent; Antibody Formation; Autoantibodies; Child; Child, Preschool; Choline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Immunologic Deficiency Syndromes; Male; Phosphorylcholine; Reference Values | 1986 |
[Clinical study on the anti-lipidemia and anti-steatosis effectiveness of the pantetheine-phosphorylcholine pharmacologic combination].
Topics: Adult; Aged; Choline; Drug Evaluation; Drug Therapy, Combination; Fat Necrosis; Female; Humans; Hyperlipidemias; Male; Middle Aged; Necrosis; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds | 1986 |
Preparation of phosphorylcholine-conjugated antigens.
Topics: Choline; Haptens; Isothiocyanates; Phosphorylcholine; Serum Albumin, Bovine; Thiocyanates | 1986 |
Selective chemical catalysis by an antibody.
Topics: Antibodies; Binding Sites; Carbonates; Catalysis; Choline; Hydrolysis; Immunoglobulin A; Kinetics; Nitrophenols; Phosphorylcholine | 1986 |
Phosphorylcholine bearing components of some helminthic parasites: localization to parasite lipoproteins.
Topics: Animals; Ascaris; Choline; Helminths; Lipoproteins; Molecular Weight; Nippostrongylus; Parasites; Phosphorylcholine; Schistosoma; Species Specificity; Strongyloidea | 1986 |
Comparative optically detected magnetic resonance studies of mammalian phospholipase A2-lipid interactions.
Topics: Animals; Cattle; Choline; Horses; Kinetics; Magnetics; Micelles; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Protein Binding; Species Specificity; Spectrum Analysis; Swine | 1987 |
The Ig class distribution of anti-phosphoryl choline responses in mice infected with parasitic nematodes.
Topics: Animals; Choline; Dipetalonema Infections; Filariasis; Immunoglobulins; Mice; Mice, Inbred Strains; Phosphorylcholine; Trichinellosis | 1986 |
Synthesis of phosphatidylcholine by rat lung during choline deficiency.
Topics: Animals; Carbon Radioisotopes; Choline; Choline Deficiency; Cytidine Diphosphate Choline; Glucose; Lung; Male; Palmitic Acid; Palmitic Acids; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains | 1986 |
Evidence for a high activity of sphingomyelin biosynthesis by phosphocholine transfer from phosphatidylcholine to ceramides in lung lamellar bodies.
Topics: Albumins; Animals; Calcium; Ceramides; Choline; Cytidine Diphosphate Choline; Hydrogen-Ion Concentration; Kinetics; Lung; Lysophosphatidylcholines; Male; Manganese; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains; Sphingomyelins; Subcellular Fractions | 1987 |
Shared idiotypy between phosphorylcholine-specific antibody and acetylcholinesterase detectable by a monoclonal antibody.
Topics: Acetylcholinesterase; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Binding, Competitive; Choline; Cholinesterase Inhibitors; Cross Reactions; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Receptors, Cholinergic; Torpedo | 1985 |
Maturation of B cell subpopulations responding to phosphorylcholine.
Topics: Animals; Antigens; Antigens, T-Independent; B-Lymphocytes; Cell Differentiation; Choline; Female; Haptens; Immunization, Passive; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Phosphorylcholine; Spleen; Stem Cells | 1985 |
Regulation of idiotope expression. I. The effect of antigen dose on expression of certain T15 idiotopes during primary IgM response to S. pneumoniae R36a.
Topics: Animals; Antibodies, Bacterial; Antibody-Producing Cells; Antigens, Bacterial; Antigens, T-Independent; B-Lymphocytes; Choline; Dose-Response Relationship, Immunologic; Female; Hemolytic Plaque Technique; Immunoglobulin Idiotypes; Immunoglobulin M; Male; Mice; Phosphorylcholine; Streptococcus pneumoniae | 1985 |
Immunologic memory to phosphorylcholine. VI. Heterogeneity in light chain gene expression.
Topics: Animals; Antibody Formation; Antibody Specificity; Choline; Gene Expression Regulation; Hybridomas; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunologic Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylcholine | 1985 |
IgA isotype-restricted idiotypes associated with T15 Id+ PC antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Binding, Competitive; Choline; Immunoglobulin A; Immunoglobulin Allotypes; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Phosphorylcholine | 1985 |
Immunologic memory to phosphocholine. VII. Lack of T15 V1 gene utilization in Xid anti-PC hybridomas.
Topics: Animals; Antibodies, Monoclonal; Antibody Diversity; Antibody Specificity; Binding Sites, Antibody; Choline; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Variable Region; Immunologic Memory; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Mutant Strains; Phosphorylcholine | 1985 |
Contrasting effect of phosphorylcholine-binding protein from rat and rabbit on heparin-lipoprotein interaction: a role of sialic acid.
Topics: Animals; Calcium; Carrier Proteins; Chemical Precipitation; Choline; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Heparin; Immunodiffusion; Immunoelectrophoresis; Inflammation; Lipoproteins; Male; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains; Sialic Acids | 1985 |
Metabolism of choline in brain of the aged CBF-1 mouse.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Chromatography, Thin Layer; Male; Mice; Mice, Inbred Strains; Phosphorylcholine; Tritium | 1986 |
Investigation of phospholipase-lipid interactions by optical detection of triplet state magnetic resonance spectroscopy.
Topics: Animals; Choline; Enzyme Precursors; Magnetic Resonance Spectroscopy; Micelles; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Swine | 1985 |
Topological biosynthesis of phosphatidylcholine in brain microsomes.
Topics: Animals; Biological Transport; Brain; Chickens; Choline; Cytidine Diphosphate Choline; Intracellular Membranes; Kinetics; Lipid Bilayers; Microsomes; Phosphatidylcholines; Phosphorylcholine; Rats | 1985 |
Turnover of phosphocholine and phosphoethanolamine in ether-phospholipids of Krebs II ascite cells.
Topics: Animals; Carcinoma, Krebs 2; Choline; Deoxycholic Acid; Ethanolamines; Glycerol; Kinetics; Mice; Phosphates; Phospholipids; Phosphorus Radioisotopes; Phosphorylcholine; Tritium | 1985 |
Binding of phytohemagglutinin to porcine lymphocyte receptors. Time-course studies and comparative binding isotherms using whole cells or cellular receptors incorporated into phospholipid vesicles.
Topics: Animals; Choline; Glycoproteins; Kinetics; Lymphocytes; Membranes, Artificial; Phosphatidylserines; Phosphorylcholine; Phytohemagglutinins; Receptors, Mitogen; Spleen; Subcellular Fractions; Swine; Temperature | 1985 |
The neuromuscular blocking action of diphenylphosphorylcholines.
Topics: Acetylcholine; Animals; Anura; Chickens; Choline; Dose-Response Relationship, Drug; Muscles; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Organophosphorus Compounds; Phosphorylcholine; Tubocurarine | 1972 |
Measurement of acetylcholine turnover rate in discrete areas of rat brain.
Topics: Acetylcholine; Animals; Brain; Brain Stem; Cerebral Cortex; Choline; Chromatography, Gas; Corpus Striatum; Infusions, Intravenous; Kinetics; Male; Mathematics; Microwaves; Phosphorylcholine; Rats; Rats, Inbred Strains | 1974 |
Effects of acute and chronic morphine on regional rat brain acetylcholine turnover rate.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Choline; Corpus Striatum; Dose-Response Relationship, Drug; Kinetics; Male; Mathematics; Microwaves; Morphine; Naloxone; Neural Pathways; Occipital Lobe; Phosphorylcholine; Rats; Rats, Inbred Strains; Substantia Nigra | 1974 |
Interaction of myelin basic protein with micelles of dodecylphosphocholine.
Topics: Animals; Choline; Circular Dichroism; Colloids; Histidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Micelles; Myelin Basic Protein; Phosphorylcholine; Protein Conformation; Rabbits; Spin Labels; Tyrosine | 1984 |
Attachment of pneumococcal autolysin to wall teichoic acids, an essential step in enzymatic wall degradation.
Topics: Adsorption; Amidohydrolases; Cell Wall; Choline; Kinetics; N-Acetylmuramoyl-L-alanine Amidase; Phosphorylcholine; Streptococcus pneumoniae; Teichoic Acids | 1984 |
Clonal nature of the immune response to phosphorylcholine. VIII. Evidence that antibodies bearing T15 idiotypic determinants in Ighj mice comprise a family of antibodies.
Topics: Animals; Binding Sites, Antibody; Choline; Clone Cells; Epitopes; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred CBA; Phosphorylcholine; Rabbits | 1980 |
Immune response to phosphorylcholine. VII. Functional evidence for three separate B cell subpopulations responding to TI and TD PC-antigens.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Choline; Epitopes; Female; Immune Tolerance; Immunoglobulin Idiotypes; Mice; Mice, Inbred A; Mice, Inbred BALB C; Phosphorylcholine; Spleen; T-Lymphocytes | 1980 |
Studies on phosphorylcholine-specific T cell idiotypes and idiotype-specific immunity.
Topics: Animals; Antibody Formation; Cell Division; Choline; DNA, Neoplasm; Epitopes; Female; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred Strains; Multiple Myeloma; Neoplasms, Experimental; Phosphorylcholine; Receptors, Antigen, T-Cell; T-Lymphocytes | 1980 |
Mechanisms of idiotype suppression. III. Relative resistance of PBA-induced anti-phosphorylcholine responses to in vitro idiotype suppression.
Topics: Animals; Antibody Formation; Cell Extracts; Choline; DNA; Epitopes; Immunoglobulin Idiotypes; Interleukin-4; Kinetics; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylcholine; Temperature; Time Factors; Tissue Extracts | 1981 |
Cross-reactivity between C-reactive protein and idiotypic determinants on A phosphocholine-binding murine myeloma protein.
Topics: Animals; Antibody Specificity; Binding Sites; C-Reactive Protein; Choline; Clone Cells; Cross Reactions; Epitopes; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Myeloma Proteins; Phosphorylcholine | 1981 |
Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopy.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; C-Reactive Protein; Carrier Proteins; Choline; Epitopes; Immunoglobulin Fab Fragments; Immunoglobulin G; Mice; Microscopy, Electron, Scanning; Phosphorylcholine; Protein Conformation | 1983 |
Heterogeneity of the human phosphocholine-specific B cell repertoire.
Topics: Adolescent; Adult; Antibodies, Heterophile; Antibody Specificity; B-Lymphocytes; Binding Sites, Antibody; Cell Transformation, Viral; Child; Child, Preschool; Choline; Clone Cells; Epitopes; Herpesviridae Infections; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Infant, Newborn; Lymphocyte Activation; Phosphorylcholine | 1984 |
Phosphorylcholine determinants in six pneumococcal capsular polysaccharides detected by monoclonal antibody.
Topics: Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antigens, Bacterial; Choline; Epitopes; Female; Mice; Mice, Inbred BALB C; Phosphorylcholine; Polysaccharides, Bacterial; Rabbits; Streptococcus pneumoniae | 1984 |
Analysis of idiotypic heterogeneity in the anti-alpha 1-3 dextran and anti-phosphorylcholine responses using monoclonal anti-idiotype antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Antibody Specificity; Autoantibodies; B-Lymphocytes; Choline; Dextrans; Gene Expression Regulation; Haptens; Hybridomas; Immunization; Immunoglobulin Idiotypes; Mice; Mice, Inbred A; Mice, Inbred BALB C; Phenotype; Phosphorylcholine; Spleen; T-Lymphocytes | 1983 |
An independent regulation of distinct idiotopes of the T15 idiotype by autologous T cells.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; B-Lymphocytes; Choline; Epitopes; Gene Expression Regulation; Hybridomas; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Phosphorylcholine; T-Lymphocytes | 1983 |
Idiotype-specific T-helper cells.
Topics: Animals; B-Lymphocytes; Choline; Epitopes; Female; Hemocyanins; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Myeloma Proteins; Phosphorylcholine; T-Lymphocytes, Helper-Inducer; Trinitrobenzenes | 1983 |
Phosphorylcholine on Streptococcus pneumoniae R36a is responsible for in vitro polyclonal antibody secretion by human peripheral blood lymphocytes.
Topics: Adult; alpha-Macroglobulins; Antibody-Producing Cells; B-Lymphocytes; Choline; Ethanolamines; Hemolytic Plaque Technique; Humans; Hydrolysis; Lymphocyte Activation; Phosphorylcholine; Polysaccharides, Bacterial; Streptococcus pneumoniae | 1984 |
Interaction of helper T cells and Lyb5+ B cells responding to phosphorylcholine is MHC-restricted.
Topics: Animals; Antigens, Ly; B-Lymphocytes; Choline; Epitopes; Female; H-2 Antigens; Hemocyanins; Immunoglobulin M; Lymphocyte Cooperation; Male; Mice; Mice, Inbred BALB C; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1984 |
Macrophage-chemotactic factor-producing T cell hybridomas reactive to phosphorylcholine in I-E-restricted manner.
Topics: Animals; Chemotactic Factors; Choline; Epitopes; Hybridomas; Isoelectric Focusing; Macrophages; Mice; Mice, Inbred BALB C; Molecular Weight; Phenotype; Phosphorylcholine; Receptors, Antigen, B-Cell; T-Lymphocytes | 1984 |
Frequencies of phosphorylcholine-specific and T15-associated 10/13 idiotope-positive B cells within lipopolysaccharide-reactive B cells of adult BALB/c mice.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Choline; Clone Cells; Epitopes; Immunoglobulin Idiotypes; Immunoglobulin M; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylcholine; Radioimmunoassay; Rats; Rats, Inbred Lew | 1984 |
[Treatment of chronic hepatopathies with phosphorylcholine and pantethine].
Topics: Adult; Aged; Choline; Chronic Disease; Drug Combinations; Female; Humans; Liver Diseases; Male; Middle Aged; Pantetheine; Phosphorylcholine; Sulfhydryl Compounds | 1984 |
Helper T lymphocytes from xid and normal mice support anti-phosphocholine antibody responses with equivalent T15, 511, and 603 idiotypic composition.
Topics: Animals; Antibody-Producing Cells; Choline; Female; Hemocyanins; Hemolytic Plaque Technique; Immune Sera; Immunization, Passive; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Immunologic Deficiency Syndromes; Male; Mice; Mice, Mutant Strains; Phosphorylcholine; T-Lymphocytes, Helper-Inducer | 1984 |
Anti-phosphorylcholine antibody-producing cells in human lymphoblastoid cell lines established by transformation with Epstein-Barr virus.
Topics: Antibody Formation; B-Lymphocytes; Cell Line; Cell Transformation, Viral; Choline; Clone Cells; Hemagglutination Tests; Herpesvirus 4, Human; Humans; Immunoglobulin M; Phosphorylcholine | 1980 |
Location and orientation relative to the micelle surface for glucagon in mixed micelles with dodecylphosphocholine: EPR and NMR studies.
Topics: Choline; Colloids; Electron Spin Resonance Spectroscopy; Glucagon; Liposomes; Magnetic Resonance Spectroscopy; Micelles; Molecular Conformation; Phosphorylcholine; Spin Labels | 1981 |
Evidence for a regulatory role of CTP : choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birth.
Topics: Animals; Animals, Newborn; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Cytosol; Female; Lung; Microsomes; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Rats | 1981 |
Complex kinetics of bis(4-methylumbelliferyl)phosphate and hexadecanoyl(nitrophenyl)phosphorylcholine hydrolysis by purified sphingomyelinase in the presence of Triton X-100.
Topics: Animals; Choline; Drug Stability; Female; Hydrolysis; Hymecromone; Kinetics; Micelles; Nitrophenols; Octoxynol; Phosphoric Diester Hydrolases; Phosphorylcholine; Placenta; Polyethylene Glycols; Sphingomyelin Phosphodiesterase; Sphingomyelins; Umbelliferones | 1982 |
A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein.
Topics: Binding Sites; Choline; Immunoglobulin A; Immunoglobulin Fab Fragments; Immunoglobulins; Magnetic Resonance Spectroscopy; Myeloma Proteins; Phosphorus Radioisotopes; Phosphorylcholine; Protein Conformation; Protons | 1982 |
Synthesis and use of new spin labeled derivatives of phosphorylcholine in a comparative study of human, dogfish, and Limulus C-reactive proteins.
Topics: Animals; C-Reactive Protein; Choline; Dogfish; Electron Spin Resonance Spectroscopy; Horseshoe Crabs; Humans; Kinetics; Phosphorylcholine; Protein Binding; Species Specificity; Spin Labels | 1983 |
Comparative hydrolysis of sphingomyelin and 2-N-(hexadecanoyl)-amino-4-nitrophenyl-phosphorylcholine by normal human brain homogenate at acid and neutral pH.
Topics: Cerebral Cortex; Choline; Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Phosphoric Diester Hydrolases; Phosphorylcholine; Sphingomyelin Phosphodiesterase; Sphingomyelins; Substrate Specificity | 1983 |
Hormonal regulation of phosphatidylcholine synthesis in plants. The inhibition of cytidylyltransferase activity by indol-3-ylacetic acid.
Topics: Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Fabaceae; Indoleacetic Acids; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Plant Development; Plants; Plants, Medicinal | 1983 |
Regulation of phosphatidylcholine metabolism in mammalian cells. Isolation and characterization of a Chinese hamster ovary cell pleiotropic mutant defective in both choline kinase and choline-exchange reaction activities.
Topics: Animals; Autoradiography; Cell Line; Choline; Choline Kinase; Cricetinae; Cricetulus; Cytidine Diphosphate Choline; Ethanolamine; Ethanolamines; Female; Nitrogenous Group Transferases; Ovary; Phosphatidylcholines; Phosphorylcholine; Phosphotransferases; Serine; Transferases | 1984 |
Red cell CDP (dCDP)-choline and P-choline in normal subjects and in certain hemolytic syndromes.
Topics: 5'-Nucleotidase; Anemia, Hemolytic; Choline; Cytidine Diphosphate Choline; Erythrocytes; Humans; Nucleotidases; Phosphatidylcholines; Phosphorylcholine; Reticulocytes | 1984 |
The effects of idiotype on the ability of IgG1 anti-phosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae.
Topics: Animals; Antibodies, Anti-Idiotypic; Choline; Immunization, Passive; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Mice, Inbred CBA; Phosphorylcholine; Pneumococcal Infections; Streptococcus pneumoniae | 1984 |
Studies on antibody repertoire: ontogenic development of mitogen-reactive B cells producing phosphorylcholine-specific and/or T15-associated 10/13 idiotope-positive antibodies.
Topics: Age Factors; Animals; Animals, Newborn; Antibody Formation; Antibody Specificity; B-Lymphocytes; Choline; Germ-Free Life; Immunoglobulin Idiotypes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1984 |
Idiotype shifts caused by neonatal tolerance to phosphorylcholine.
Topics: Animals; Animals, Newborn; Antibody-Producing Cells; B-Lymphocytes; Choline; Clone Cells; Dose-Response Relationship, Immunologic; Female; Hemolytic Plaque Technique; Immune Tolerance; Immunization, Passive; Immunoglobulin Idiotypes; Lymphocyte Activation; Lymphocyte Cooperation; Male; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1983 |
The preparation of stable phosphorylcholine-erythrocyte conjugates for use in plaque assays.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibody-Producing Cells; Choline; Erythrocytes; Hemolytic Plaque Technique; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Phenylacetates; Phosphorylcholine | 1983 |
A new sensitive assay for the calcium-dependent binding of C-reactive protein to phosphorylcholine.
Topics: Animals; Binding, Competitive; C-Reactive Protein; Calcium; Chelating Agents; Choline; Detergents; Dose-Response Relationship, Drug; Immunosorbent Techniques; Phosphorylcholine; Polysaccharides, Bacterial; Protein Binding; Pyridoxal Phosphate; Rabbits; Serum Albumin, Bovine | 1983 |
Inhibition of antibody responses to phosphocholine by C-reactive protein.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Bacterial Vaccines; Binding, Competitive; C-Reactive Protein; Choline; Elapid Venoms; Female; Hemolytic Plaque Technique; Humans; Mice; Mice, Inbred BALB C; Phosphorylcholine; Pneumococcal Vaccines; Time Factors | 1984 |
Phosphorylcholine on isologous red blood cells induces polyclonal but not anti-phosphorylcholine plaque-forming cells in mice.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Choline; Erythrocytes; Female; Haptens; Hemolytic Plaque Technique; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylcholine; Species Specificity; Streptococcus | 1984 |
Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Binding Sites, Antibody; Biological Evolution; Choline; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred Strains; Phosphorylcholine; Polymorphism, Genetic | 1983 |
Amino acid sequence of a phosphocholine-binding antibody from an immune defective CBA/N mouse employing the T15 VH region associated with unusual DH, JH, and V kappa segments.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Choline; DNA, Mitochondrial; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mitochondria, Liver; Phosphorylcholine | 1984 |
Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens; Binding Sites, Antibody; Binding, Competitive; Choline; DNA, Mitochondrial; Female; Haptens; Hemocyanins; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Variable Region; Immunologic Memory; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Phosphorylcholine | 1984 |
Immunologic memory to phosphocholine. V. Hybridomas representative of group II antibodies utilize V kappa 1-3 gene(s).
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Diversity; Binding Sites, Antibody; Choline; Female; Hybridomas; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Immunologic Memory; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1984 |
The role of a novel VH sequence (V11) in the formation of anti-phosphocholine antibodies.
Topics: Amino Acid Sequence; Animals; Antibody Formation; Binding Sites, Antibody; Choline; Electrophoresis, Polyacrylamide Gel; Genes, MHC Class II; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Myeloma Proteins; Phosphorylcholine | 1984 |
Detection of the dominant expression of the TEPC-15 idiotypic determinant(s) on phosphorylcholine-specific suppressor T lymphocytes in vitro.
Topics: Animals; Choline; Genes, Dominant; Haptens; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Phosphorylcholine; T-Lymphocytes, Regulatory | 1981 |
Demonstration of T15 idiotype-positive effector and suppressor T cells for phosphorylcholine-specific delayed-type hypersensitivity response in CBA/N or (CBA/N X BALB/c)F1 male mice.
Topics: Animals; Cell Adhesion; Choline; Hypersensitivity, Delayed; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; p-Azobenzenearsonate; Phosphorylcholine; T-Lymphocytes, Regulatory | 1981 |
The rate-limiting reaction in phosphatidylcholine synthesis by alveolar type II cells isolated from fetal rat lung.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Female; Fetus; Kinetics; Lung; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Rats; Tritium | 1984 |
Lack of IgA subclass restriction in antibody response to phosphorylcholine, beta lactoglobulin and tetanus toxoid.
Topics: Adult; Antibody Specificity; Antigens; Choline; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin A; Lactoglobulins; Phosphorylcholine; Tetanus Toxoid | 1984 |
Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia.
Topics: Animals; Antibodies, Bacterial; Blood Bactericidal Activity; Choline; Dose-Response Relationship, Immunologic; Immunization, Passive; Mice; Mice, Inbred CBA; Mice, Mutant Strains; Phosphorylcholine; Pneumococcal Infections; Sepsis; Streptococcus pneumoniae; Time Factors; Virulence | 1984 |
pH dependence of the binding constant of a phospholipase A2 from Agkistrodon halys blomhoffii venom to micelles of n-hexadecylphosphorylcholine.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Choline; Crotalid Venoms; Hydrogen-Ion Concentration; Mathematics; Micelles; Models, Chemical; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Protein Binding; Spectrometry, Fluorescence | 1984 |
Modulations of glycerophosphorylcholine and phosphorylcholine in Friend erythroleukemia cells upon in vitro-induced erythroid differentiation: a 31P NMR study.
Topics: Acetamides; Animals; Cell Differentiation; Choline; Clone Cells; Dimethyl Sulfoxide; Erythrocytes; Glycerylphosphorylcholine; Leukemia, Erythroblastic, Acute; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Phosphorylcholine | 1984 |
Contribution of Lyb 5+ and Lyb 5- B cells to the primary and secondary phosphocholine-specific antibody response.
Topics: Animals; Antibody Formation; Antigens, Ly; B-Lymphocytes; Choline; Female; Hematopoietic Stem Cells; Immunization, Secondary; Immunoglobulin Idiotypes; Immunoglobulin M; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Phosphorylcholine; Rabbits; Spleen | 1983 |
Labeled choline and phosphorylcholine: body distribution and brain autoradiography: concise communication.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Choline; Female; Macaca; Male; Mice; Phosphorylcholine; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed | 1983 |
Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire.
Topics: Animals; Animals, Newborn; B-Lymphocytes; Bone Marrow Cells; Choline; Female; Gene Expression Regulation; Immunoglobulin Idiotypes; Immunoglobulin Variable Region; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine; Selection, Genetic | 1983 |
Bindings of cobra venom phospholipases A2 to micelles of n-hexadecylphosphorylcholine.
Topics: Animals; Choline; Elapid Venoms; Hydrogen-Ion Concentration; Kinetics; Micelles; Phospholipases; Phospholipases A; Phosphorylcholine; Protein Binding; Spectrometry, Fluorescence | 1983 |
[Clinical study of the combination of calcium phosphorylcholine and pantetheine].
Topics: Adult; Aged; Arteriosclerosis; Choline; Drug Therapy, Combination; Female; Humans; Lipidoses; Male; Middle Aged; Pantetheine; Phosphorylcholine; Research Design; Sulfhydryl Compounds | 1983 |
Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations.
Topics: Acylation; Animals; Choline; Chromatography, Gas; Hydrolysis; Molecular Conformation; Phosphorylcholine; Sphingosine; Spinal Cord; Stereoisomerism; Swine; Type C Phospholipases | 1983 |
Activation of complement in C-reactive protein positive sera by phosphorylcholine-bearing component isolated from parasite extract.
Topics: Animals; Ascaridoidea; C-Reactive Protein; Choline; Complement Activation; Diphyllobothrium; Humans; Paragonimus; Phosphorylcholine; Toxocara; Trichinella | 1983 |
Regulatory effects of isologous anti-idiotypic antibodies on the formation of different immunoglobulin classes in the immune response to phosphorylcholine in BALB/c mice.
Topics: Animals; Antibody Formation; Choline; Female; Immunoglobulin E; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulins; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1984 |
Subpopulations of antibodies to phosphocholine in human serum.
Topics: Animals; Antibodies; Antibody Diversity; Antibody Specificity; Bacterial Vaccines; Binding Sites, Antibody; Binding, Competitive; Choline; Humans; Immunoglobulin G; Mice; Mice, Inbred BALB C; Phosphorylcholine; Pneumococcal Vaccines; Streptococcus pneumoniae | 1984 |
Uptake and output of various forms of choline by organs of the conscious chronically catheterized sheep.
Topics: Animals; Blood Flow Velocity; Catheterization; Choline; Glycerylphosphorylcholine; Lipid Metabolism; Lipids; Male; Phosphorylcholine; Rats; Rats, Inbred Strains; Sheep; Tissue Distribution | 1984 |
Inhibition of ornithine decarboxylase and glutamic acid decarboxylase activities by phosphorylethanolamine and phosphorylcholine.
Topics: Animals; Cerebellum; Choline; Ethanolamines; Ganglia, Sympathetic; Glutamate Decarboxylase; Kidney; Kinetics; Liver; Mice; Mice, Inbred ICR; Ornithine Decarboxylase Inhibitors; Phosphorylcholine; Rats; Rats, Inbred Strains | 1984 |
Pneumococcal cell wall phosphorylcholine elicits polyclonal antibody secretion in mice.
Topics: Animals; Animals, Newborn; Antibodies; Antibody Formation; Choline; Female; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Nude; Phosphorylcholine; Species Specificity; Staphylococcal Infections; Staphylococcus | 1984 |
Expression of a distinct B cell clonotype profile after recovery from antigen-induced unresponsiveness.
Topics: Aging; Animals; Antibody-Producing Cells; Antigens; B-Lymphocytes; Choline; Clone Cells; Hemolytic Plaque Technique; Immune Tolerance; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylcholine; Trinitrobenzenes | 1982 |
Phosphorylcholine-binding hybridoma proteins of normal and idiotypically suppressed BALB/c mice II. Variable region N-terminal amino acid sequences.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Antibodies, Anti-Idiotypic; Binding Sites, Antibody; Choline; Hybrid Cells; Immune Tolerance; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1980 |
Clonotypes of anti-phosphocholine antibodies induced with Proteus morganii (Potter). I. Structural and idiotypic similarities in a diverse repertoire.
Topics: Animals; Antibodies; Antibody Formation; Antigens; Binding Sites, Antibody; Choline; Clone Cells; Female; Guinea Pigs; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Male; Mice; Mice, Inbred BALB C; Phosphorylcholine; Rabbits | 1980 |
The isolation of an allergen from extracts of Dermatophagoides pteronyssinus using a murine IgA myeloma with a specificity for phosphorylcholine.
Topics: Allergens; Animals; Chemical Precipitation; Choline; Chromatography, Gel; Concanavalin A; Humans; Immunodiffusion; Immunoglobulin A; Mice; Mice, Inbred BALB C; Mites; Myeloma Proteins; Phosphorylcholine; Precipitins; Radioallergosorbent Test | 1980 |
Isolation of a phosphorylcholine-containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C-reactive protein.
Topics: Animals; C-Reactive Protein; Cestoda; Choline; Chromatography, Thin Layer; Fishes; Immunodiffusion; Immunoelectrophoresis; Isoelectric Focusing; Phosphorylcholine; Skin Tests | 1980 |
Anti-phosphocholine hybridoma antibodies. I. Direct evidence for three distinct families of antibodies in the murine response.
Topics: Animals; Antibodies; Binding Sites, Antibody; Cell Fusion; Choline; Hybrid Cells; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Immunoglobulins; Isoelectric Focusing; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine | 1981 |
A novel phosphorylcholine-binding protein from rat serum and its effect on heparin-lipoprotein complex formation in the presence of calcium.
Topics: Amino Acids; Animals; Calcium; Carrier Proteins; Choline; Chromatography, Affinity; Chylomicrons; Heparin; Immunodiffusion; Lipoproteins; Molecular Weight; Phosphorylcholine; Rats | 1981 |
Nucleic acid and protein sequences of phosphocholine-binding light chains.
Topics: Amino Acid Sequence; Animals; Base Sequence; Choline; Immunoglobulin Light Chains; Mice; Phosphorylcholine | 1981 |
Characterization of phosphorylcholine- (PC) specific IgE-B cells in CBA/N or (CBA/N x BALB/c)F1 male mice.
Topics: Animals; Antibody Specificity; B-Lymphocytes; Binding Sites; Carrier Proteins; Choline; Immunization, Passive; Immunoglobulin delta-Chains; Immunoglobulin E; Immunoglobulin epsilon-Chains; Immunoglobulin Idiotypes; Immunoglobulin M; Immunoglobulin mu-Chains; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine; Rabbits | 1981 |
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Base Sequence; Binding Sites, Antibody; Choline; Genes, MHC Class II; Immunization; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Immunoglobulins; Mice; Mice, Inbred BALB C; Mutation; Phosphorylcholine | 1981 |
Mechanism of clonal dominance in the murine anti-phosphorylcholine response. I. Relation between antibody avidity and clonal dominance.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antibody Affinity; Antibody-Producing Cells; Brucella abortus; Choline; Female; Genes, Dominant; Immunosuppression Therapy; Lipopolysaccharides; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Nude; Phosphorylcholine; Spleen | 1982 |
The immune response of BALB/c mice to phosphorylcholine is restricted to a limited number of VH- and VL-isotypes.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Antibody Formation; Binding Sites, Antibody; Choline; Hybridomas; Immunoglobulin Allotypes; Immunoglobulin Heavy Chains; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1981 |
Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies.
Topics: Animals; Antibodies; Cell Line; Cells, Cultured; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hybridomas; Immunoglobulin Heavy Chains; Immunoglobulin Idiotypes; Immunoglobulin Light Chains; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloma Proteins; Neoplasms, Experimental; Phosphorylcholine; Plasmacytoma; Spleen; T-Lymphocytes | 1982 |
Isolated phosphorylcholine binding lymphocytes. I. Use of a cleavable crosslinking reagent for solid-phase adsorbent isolation of functional antigen binding cells.
Topics: Animals; Antibody-Producing Cells; Binding Sites; Brucella abortus; Cell Differentiation; Cell Separation; Choline; Cross-Linking Reagents; Horses; Humans; Immunosorbent Techniques; Lymphocytes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Plasmacytoma; Rabbits; Rosette Formation; Spleen; Succinimides | 1982 |
Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Chemical Phenomena; Chemistry; Choline; Female; Mice; Mice, Inbred BALB C; Phosphorylcholine; Pneumococcal Infections; Polysaccharides, Bacterial; Streptococcus pneumoniae | 1983 |
Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies.
Topics: Antibodies, Monoclonal; Antibody Diversity; Antibody Specificity; Choline; Immunoglobulin G; Immunoglobulin M; Kinetics; Phosphorylcholine | 1983 |
Resistance to Streptococcus pneumoniae is induced by a phosphocholine-protein conjugate.
Topics: Animals; Antigens; Antigens, Bacterial; Cell Wall; Choline; Hemocyanins; Immunity, Active; Immunoglobulin Allotypes; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Phosphorylcholine; Pneumococcal Infections | 1983 |
Binding of phosphorylcholine by non-immunoglobulin molecules on mouse B cells.
Topics: Animals; Antibodies, Monoclonal; Antigens, Bacterial; Binding Sites; Bone Marrow Cells; Choline; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred NZB; Mice, Mutant Strains; Phosphorylcholine; Receptors, Antigen, B-Cell; Serum Albumin, Bovine; Spleen; Streptococcus pneumoniae | 1983 |
[Effect of choline compounds on rosette formation in mouse lymphocytes].
Topics: Acetylcholine; Animals; Atropine; Benzoylcholine; Choline; Mice; Mice, Inbred BALB C; Phosphorylcholine; Receptors, Cholinergic; Rosette Formation | 1983 |
An allotype linked gene that is associated with a negative or very low anti-phosphorylcholine response (PC) phenotype in wild mice (CNV).
Topics: Animals; Antibodies, Bacterial; Choline; Crosses, Genetic; Fructans; Immunoglobulin Allotypes; Immunoglobulin Constant Regions; Inulin; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Phosphorylcholine; Streptococcus pneumoniae | 1983 |
Choline accumulation by photoreceptor cells of the rabbit retina.
Topics: Acetylcholine; Animals; Biological Transport; Choline; Kinetics; Phosphorylcholine; Rabbits; Retina | 1980 |
Uptake of free choline by isolated perfused rat liver.
Topics: Animals; Betaine; Biological Transport; Choline; Kinetics; Liver; Perfusion; Phosphatidylcholines; Phosphorylcholine; Rats | 1980 |
The natural occurence of circulating idiotype--anti-idiotype complexes during a secondary immune response to phosphorylcholine.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigen-Antibody Complex; Antigens, Bacterial; Choline; Female; Immunization, Secondary; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; Streptococcus | 1980 |
Phosphorylcholine-binding hybridoma proteins of normal and idiotypically suppressed BALB/c mice I. Characterization and idiotypic analysis.
Topics: Animals; Animals, Newborn; Antibodies, Anti-Idiotypic; Antibody Formation; Choline; Hybrid Cells; Immune Tolerance; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1980 |
Idiotypic profile of the response to phosphorylcholine induced in the absence of the homologous antigen.
Topics: Animals; Antigens; B-Lymphocytes; Carrier Proteins; Choline; Clone Cells; H-2 Antigens; Immunoglobulin Idiotypes; Immunologic Memory; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phosphorylcholine; Plasmacytoma; Receptors, Antigen, B-Cell | 1980 |
Late clonal selection and expansion of the TEPC-15 germ-line specificity.
Topics: Animals; Animals, Newborn; B-Lymphocytes; Choline; Clone Cells; Female; Immunoglobulin Idiotypes; Liver; Mice; Mice, Inbred BALB C; Phosphorylcholine; Selection, Genetic; Spleen; T-Lymphocytes | 1980 |
Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype.
Topics: Animals; Antibody Formation; Choline; Immunoglobulin Idiotypes; Isoantigens; Lymphocyte Activation; Lymphocyte Cooperation; Major Histocompatibility Complex; Mice; Phosphorylcholine; T-Lymphocytes | 1981 |
Antibodies from the Lyb-5- B cell subset predominate in the secondary IgG response to phosphocholine.
Topics: Animals; Antibody Formation; Antibody Specificity; Antigens, Ly; B-Lymphocytes; Choline; Immunization, Passive; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Immunologic Memory; Mice; Mice, Inbred Strains; Phosphorylcholine | 1982 |
Regulation of T15 idiotype dominance. I. Mice expressing the xid immune defect provide normal help to T15+ B cell precursors.
Topics: Animals; Antibody Formation; B-Lymphocytes; Choline; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Lymphocyte Cooperation; Male; Mice; Mice, Mutant Strains; Phosphorylcholine; Spleen; T-Lymphocytes | 1982 |
Immunologic memory to phosphorylcholine III. IgM includes a fine specificity population distinct from TEPC 15.
Topics: Animals; Antibody Specificity; B-Lymphocytes; Choline; Clone Cells; Female; Hemocyanins; Immunoglobulin Idiotypes; Immunoglobulin M; Immunologic Memory; Mice; Phosphorylcholine; Time Factors | 1982 |
Murine immunogenicity of N-substituted phosphatidylethanolamine derivatives in liposomes: response to the hapten phosphocholine.
Topics: Animals; Antibody Formation; Choline; Dose-Response Relationship, Immunologic; Haptens; Hemolytic Plaque Technique; Immunoglobulin Idiotypes; Immunoglobulin M; Lipid A; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Phosphatidylethanolamines; Phosphorylcholine | 1980 |
Induction of clonally restricted thymus-dependent antibody responses in vitro using phosphorylcholine derivatized sheep erythrocytes.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; Choline; Clone Cells; Dose-Response Relationship, Immunologic; Erythrocytes; Female; Hemolytic Plaque Technique; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Phosphorylcholine; T-Lymphocytes; Time Factors | 1980 |
Immunologic memory to phosphorylcholine in vitro. I. Asymmetric expression of clonal dominance.
Topics: Animals; Choline; Clone Cells; Dose-Response Relationship, Immunologic; Female; Genes, Dominant; Haptens; Hemocyanins; Hemolytic Plaque Technique; Immunoglobulin G; Immunoglobulin Idiotypes; Immunologic Memory; Kinetics; Mice; Mice, Inbred BALB C; Phosphorylcholine; Rabbits | 1981 |
Immune response to phosphorylcholine. IX. Characterization of hybridoma anti-TEPC15 antibodies.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; Antibody-Producing Cells; Binding Sites, Antibody; Choline; Hemolytic Plaque Technique; Hybridomas; Immunoglobulin Allotypes; Immunoglobulin Idiotypes; Mice; Mice, Inbred A; Mice, Inbred BALB C; Phosphorylcholine; Rabbits | 1982 |
Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antibody Formation; Antibody Specificity; Antibody-Producing Cells; Antigens, Heterophile; Choline; Clone Cells; Hemolytic Plaque Technique; Hybridomas; Immunosuppression Therapy; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Phosphorylcholine; Sheep | 1981 |
Mice with the xid defect have helper cells for T15 idiotype-dominant anti-phosphorylcholine primary and secondary plaque-forming cells responses.
Topics: Animals; Antibody-Producing Cells; B-Lymphocytes; Choline; Female; Hemolytic Plaque Technique; Immunization; Immunization, Secondary; Immunoglobulin Idiotypes; Immunologic Deficiency Syndromes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine; T-Lymphocytes | 1982 |
Clonotypes of anti-phosphocholine antibodies induced with Proteus morganii (Potter). II. Heterogeneity, class, and idiotypic analyses of the repertoires in BALB/c and A/HeJ mice.
Topics: Animals; Antibody Specificity; Choline; Clone Cells; Hydrogen-Ion Concentration; Immunoglobulin G; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred A; Mice, Inbred BALB C; Phosphorylcholine; Proteus | 1982 |
Immunologic memory to phosphorylcholine. II. PC-KLH induces two antibody populations that dominate different isotypes.
Topics: Animals; Antibody Specificity; Binding Sites, Antibody; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hemocyanins; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Memory; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1982 |
Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Choline; Haptens; Immunoglobulin G; Immunoglobulin M; Lymphocytes; Mice; Mice, Inbred BALB C; Phosphorylcholine | 1982 |
Phosphorylcholine and phosphorylethanolamine concentrations in the lens.
Topics: Aging; Animals; Cataract; Chickens; Choline; Culture Techniques; Ethanolamines; Female; Humans; Lens, Crystalline; Male; Organophosphorus Compounds; Phosphorylcholine; Rabbits; Rats; Rats, Inbred Strains | 1982 |
Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.
Topics: Choline; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Humans; Phorbol Esters; Phorbols; Phosphatidylcholines; Phospholipases; Phospholipids; Phosphorylcholine; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
Topics: Animals; Antibodies, Bacterial; Antibodies, Monoclonal; Antigen-Antibody Reactions; Choline; Female; Immunization, Passive; Immunoglobulin M; Male; Mice; Mice, Inbred CBA; Phosphorylcholine; Pneumococcal Infections; Streptococcus pneumoniae | 1982 |
Choline administration elevates brain phosphorylcholine concentrations.
Topics: Acetylcholine; Animals; Brain; Choline; Corpus Striatum; Kinetics; Male; Phosphorylcholine; Rats; Rats, Inbred Strains | 1982 |
Sequential resonance assignments in protein 1H nuclear magnetic resonance spectra. Glucagon bound to perdeuterated dodecylphosphocholine micelles.
Topics: Amino Acid Sequence; Animals; Cattle; Choline; Colloids; Computers; Deuterium; Glucagon; Magnetic Resonance Spectroscopy; Micelles; Phosphorylcholine; Protein Conformation | 1982 |
Proton nuclear magnetic resonance of intact Friend leukemia cells: phosphorylcholine increase during differentiation.
Topics: Animals; Cell Differentiation; Choline; Kinetics; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Phosphorylcholine | 1982 |
Synthesis of enzyme-inhibitory phospholipid analogs. III. A facile synthesis of N-acylaminoethylphosphorylcholines.
Topics: Chemical Phenomena; Chemistry; Choline; Phosphatidylcholines; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine | 1982 |
Elicitation of delayed-type hypersensitivity to phosphorylcholine by monoclonal anti-idiotypic antibodies in an allogeneic environment.
Topics: Animals; Antibodies, Monoclonal; Choline; Cyclophosphamide; Hypersensitivity, Delayed; Immunoglobulin Idiotypes; Mice; Mice, Inbred Strains; Phosphorylcholine; Species Specificity | 1982 |
Acetylation and phosphorylation of choline following high or low affinity uptake by rat cortical synaptosomes.
Topics: Acetylation; Acetylcholine; Animals; Biological Transport; Cerebral Cortex; Choline; Kinetics; Phosphorylation; Phosphorylcholine; Physostigmine; Rats; Synaptosomes | 1982 |
Relationship between choline derivatives and mouse erythrocyte membrane antigens revealed by mouse monoclonal antibodies. I. Anticholine activity of anti-mouse erythrocyte monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Choline; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Erythrocytes; Hybrid Cells; Hybridomas; Immunoglobulin M; Mice; Mice, Inbred NZB; Phosphorylcholine | 1982 |
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.
Topics: Animals; Antibodies, Monoclonal; Choline; Immunoglobulin Idiotypes; Immunoglobulin M; Male; Mice; Mice, Inbred Strains; Phosphorylcholine; Pneumococcal Infections; Streptococcus pneumoniae | 1982 |
[Treatment of hyperdyslipidemia in chronic atherosclerotic peripheral obliterating arteriopathies of the lower limbs].
Topics: Adult; Aged; Arterial Occlusive Diseases; Arteriosclerosis; Cholesterol; Choline; Female; Humans; Hyperlipidemias; Hyperlipoproteinemias; Leg; Male; Middle Aged; Phosphorylcholine; Triglycerides | 1982 |
[Synthesis and biological activity of some lysing and fusogenically active phosphocholine derivatives].
Topics: Cell Fusion; Chemical Phenomena; Chemistry; Choline; Hemolysis; Humans; In Vitro Techniques; Phosphorylcholine; Protoplasts | 1982 |
Hydrolysis of p-nitrophenylphosphorylcholine by alkaline phosphatase and phospholipase C from rabbit sperm-acrosome.
Topics: Acrosome; Alkaline Phosphatase; Animals; Choline; Electrophoresis, Disc; Male; Phospholipases; Phosphorylcholine; Rabbits; Semen; Spermatozoa; Type C Phospholipases; Vasectomy | 1982 |
The lack of compensatory increases of cells producing anti-phosphorylcholine antibodies bearing other idiotypes in TEPC-15 idiotype-suppressed inbred and outbred mice.
Topics: Animals; Antibody-Producing Cells; Antigens, Neoplasm; Choline; Immune Tolerance; Immunoglobulin Idiotypes; Mice; Mice, Inbred Strains; Phosphorylcholine | 1980 |
Altered idiotype response to phosphocholine in mice bearing an x-linked immune defect.
Topics: Animals; Cell Separation; Choline; Female; Flow Cytometry; Immunoglobulin Idiotypes; Immunoglobulin M; Immunologic Deficiency Syndromes; Isoelectric Focusing; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Phosphorylcholine; Sex Chromosomes; Spleen; X Chromosome | 1981 |
Analysis of T15 idiotopes by monoclonal antibodies: variability of idiotopic expression on phosphorylcholine-specific lymphocytes from individual inbred mice.
Topics: Animals; Antibodies, Monoclonal; Antibody-Producing Cells; Choline; Dose-Response Relationship, Immunologic; Immunization; Immunoglobulin Idiotypes; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylcholine; Time Factors | 1982 |
Pulmonary phosphatidylcholine biosynthesis. Alterations in the pool sizes of choline and choline derivatives in rabbit fetal lung during development.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Gestational Age; Lung; Phosphatidylcholines; Phosphorylcholine; Rabbits | 1981 |
Immune response to phosphorylcholine. VIII. The response CBA/N mice to PC-LPS.
Topics: Aging; Animals; Antibody Formation; Antibody Specificity; Choline; Female; Immunoglobulin G; Immunoglobulin Idiotypes; Immunologic Deficiency Syndromes; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine | 1981 |
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.
Topics: Amino Acid Sequence; Animals; Antibody Diversity; Binding Sites, Antibody; Choline; Clone Cells; Genes; Hybrid Cells; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Immunoglobulin Variable Region; Mice; Mutation; Myeloma Proteins; Phosphorylcholine | 1981 |
Hormonal induction of pulmonary maturation in the rabbit fetus: effects of maternal treatment with estradiol-17 beta on th endogenous levels of cholinephosphate, CDP-choline and phosphatidylcholine.
Topics: Animals; Choline; Cytidine Diphosphate Choline; Estradiol; Female; Fetus; Lung; Maternal-Fetal Exchange; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Rabbits | 1981 |
[(3)H]Choline uptake and metabolism in nonsynaptic regions of a crustacean sensory nerve.
Topics: Acetylcholine; Animals; Axons; Brachyura; Choline; Dendrites; Hemicholinium 3; Kinetics; Male; Neurons; Phosphorylcholine; Sense Organs; Stomach | 1981 |
Carrier mediated transport of choline in rat lens.
Topics: Aging; Animals; Biological Transport, Active; Choline; Culture Techniques; Ethanolamines; Lens, Crystalline; Male; Organophosphorus Compounds; Phosphorylcholine; Rats; Time Factors | 1981 |
Bindings of monodispersed n-alkylphosphorylcholines to cobra venom phospholipases A2.
Topics: Calcium; Choline; Chromatography, Gel; Circular Dichroism; Elapid Venoms; Hydrogen-Ion Concentration; Phospholipases; Phospholipases A; Phosphorylcholine | 1981 |
Bindings of Ca2+ ion and monodispersed n-alkylphosphorylcholines to phospholipase A2-II of A. halys blomhoffii.
Topics: Calcium; Choline; Circular Dichroism; Crotalid Venoms; Hydrogen-Ion Concentration; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Spectrophotometry, Ultraviolet | 1981 |
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; Choline; Crosses, Genetic; Female; Hybrid Cells; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Phosphorylcholine; Pneumococcal Infections; Streptococcus pneumoniae | 1981 |
Clonal regulation in the response to phosphorylcholine. II. Heterogeneity among T15 idiotype-positive antibodies in inbred and wild mice.
Topics: Animals; Antibody Formation; Choline; Clone Cells; Immunoglobulin G; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Muridae; Phosphorylcholine | 1981 |
Binding reactivity of C-reactive protein for polycations. II. Modulatory effects of calcium and phosphocholine.
Topics: Binding Sites; C-Reactive Protein; Calcium; Cations; Chemical Precipitation; Choline; Glycerylphosphorylcholine; Humans; Peptides; Phosphorylcholine; Polylysine; Polymers | 1981 |
Melittin bound to dodecylphosphocholine micelles. H-NMR assignments and global conformational features.
Topics: Bee Venoms; Choline; Colloids; Magnetic Resonance Spectroscopy; Melitten; Micelles; Phosphorylcholine; Protein Conformation | 1981 |
Anti-phosphocholine hybridoma antibodies. II. Functional analysis of binding sites within three antibody families.
Topics: Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Binding, Competitive; Choline; Haptens; Hybridomas; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1981 |
Reversal of the normal pattern of renal choline metabolism during uremia in rats.
Topics: Animals; Betaine; Choline; Kidney; Kidney Failure, Chronic; Nephrectomy; Phosphorylcholine; Rats; Rats, Inbred Strains; Time Factors; Uremia | 1981 |
pH-dependence of the binding constant of monodispersed n-dodecylphosphorylcholine to the phospholipase A2 of A, Halys blomhoffii. Participation of ionizable groups with pK of 5.16 and 7.30.
Topics: Aspartic Acid; Calcium; Choline; Hydrogen-Ion Concentration; Ions; Mathematics; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Snake Venoms; Spectrophotometry, Ultraviolet | 1981 |
Determination of choline, phosphorylcholine, and betaine.
Topics: Animals; Betaine; Choline; Humans; Liver; Methods; Organ Specificity; Phosphorylcholine | 1981 |
[Effect of anti-idiotypes on the production of phosphorylcholine-specific antibodies].
Topics: Animals; Antibody Formation; Antibody Specificity; Choline; Hemocyanins; Immunization; Immunoglobulin E; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Myeloma Proteins; Phosphorylcholine | 1981 |
A single-vial biphasic liquid extraction assay for choline acetyltransferase using [3H]choline.
Topics: Acetyl Coenzyme A; Acetylcholine; Caenorhabditis; Choline; Choline O-Acetyltransferase; Kinetics; Methods; Phosphorylcholine; Tritium | 1981 |
A clinical assay for prostatic acid phosphatase using choline phosphate as a substrate: comparison with thymolphthalein phosphate.
Topics: Acid Phosphatase; Choline; Clinical Enzyme Tests; Colorimetry; Humans; Male; Phenolphthaleins; Phosphorylcholine; Prostate; Prostatic Neoplasms; Thymolphthalein | 1981 |
Effect of lysolecithin on blood vessel reactivity and of some ethers and esters of glycerophosphocholine and phosphocholine, respectively, on aggregation of rat platelets.
Topics: Animals; Blood Pressure; Choline; Drug Interactions; Glycerylphosphorylcholine; In Vitro Techniques; Lysophosphatidylcholines; Male; Muscle, Smooth, Vascular; Phosphorylcholine; Platelet Aggregation; Rats; Rats, Inbred Strains | 1981 |
Measurement of intercellular coupling between oocytes and cumulus cells using intracellular markers.
Topics: Aminoglutethimide; Animals; Cell Communication; Cells, Cultured; Choline; Female; Gonadotropins, Pituitary; Intercellular Junctions; Oocytes; Ovarian Follicle; Ovum; Phosphorylcholine; Sheep; Steroids | 1980 |
Specific clonal regulation in the response to phosphocholine. I. Genetic analysis of the response of a distinct idiotype (M511 Id).
Topics: Animals; Choline; Clone Cells; Genes; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylcholine | 1980 |
The diagnosis of type A and type B Niemann Pick disease and detection of carriers using leukocytes and a chromogenic analogue of sphingomyelin.
Topics: Choline; Genetic Carrier Screening; Humans; Leukocytes; Niemann-Pick Diseases; Nitrophenols; Phosphorylcholine | 1980 |
Clonal nature of the immune response to phosphocholine. VII. Evidence throughout inbred mice for molecular similarities among antibodies bearing the T15 idiotype.
Topics: Animals; Choline; Clone Cells; Immunoglobulin G; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylcholine; Rabbits | 1980 |
[Influency of phosphorylation on pharmacological properties of biological active compounds (author's transl)].
Topics: Choline; Phosphorylation; Phosphorylcholine; Structure-Activity Relationship | 1980 |
Clonal nature of the immune response to phosphocholine. IX. Heterogeneity among antibodies bearing M511 idiotypic determinants.
Topics: Animals; Antibody Formation; Choline; Clone Cells; Goats; Immunoglobulin G; Immunoglobulin Idiotypes; Isoelectric Focusing; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred C57BL; Phosphorylcholine; Rabbits | 1980 |
Concentrations of glycerophosphocholine, phosphocholine and free inorganic phosphate in the luminal fluid of the rat testis and epididymis.
Topics: Animals; Body Fluids; Choline; Epididymis; Glycerylphosphorylcholine; Male; Phosphates; Phosphorylcholine; Rats; Testis | 1980 |
A theoretical study on the specificity of tetramethylammonium versus monomethylammonium binding to the active site of a phosphorylcholine antibody.
Topics: Amino Acids; Binding Sites, Antibody; Choline; Immunoglobulin A; Methylamines; Models, Chemical; Phosphorylcholine; Quaternary Ammonium Compounds; Thermodynamics | 1980 |
Allelic forms of anti-phosphorylcholine antibodies.
Topics: Alleles; Animals; Antibodies; Antibody Specificity; Choline; Hemagglutination Tests; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Myeloma Proteins; Phosphorylcholine; Streptococcus pneumoniae | 1981 |
CBA/N X BALB/cJ F1 male and female mice can be primed to express quantitatively equivalent secondary anti-phosphocholine responses.
Topics: Animals; Antibody Formation; Choline; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Phosphorylcholine; Time Factors | 1981 |
Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet.
Topics: Administration, Oral; Animals; Betaine; Brain; Carbon Radioisotopes; Choline; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Diet; Dose-Response Relationship, Drug; Female; Fetus; Food, Fortified; Intestinal Absorption; Liver; Nootropic Agents; Phosphatidylcholines; Phosphorylcholine; Placenta; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 1995 |
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchange; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 1995 |
Radioactive choline metabolism in guinea pig gallbladder. Is there measurable acetylcholine release?
Topics: Acetylcholine; Animals; Betaine; Carbon Radioisotopes; Choline; Female; Gallbladder; Guinea Pigs; Phosphorylcholine; Sincalide; Time Factors | 1995 |
Localized in vivo 1H magnetic resonance spectroscopy and in vitro analyses of heterogeneous brain tumors.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Female; Glycerylphosphorylcholine; Humans; Hydrogen; Lactates; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Meningioma; Middle Aged; Oligodendroglioma; Phosphorylcholine; Solubility; Water | 1995 |
The measurement of phospholipase D-linked signaling in cells.
Topics: Animals; Cells; Choline; Humans; Methods; Phospholipase D; Phosphorylcholine; Signal Transduction | 1995 |
Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells.
Topics: Animals; Aromatase; Cells, Cultured; Ceramides; Choline; Female; Follicle Stimulating Hormone; Granulosa Cells; Kinetics; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Serine; Sphingomyelins; Tritium; Tumor Necrosis Factor-alpha | 1995 |
Choline ingestion increases the resonance of choline-containing compounds in human brain: an in vivo proton magnetic resonance study.
Topics: Acetylcholine; Adult; Brain; Choline; Dose-Response Relationship, Drug; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy; Male; Neurons; Nutritional Requirements; Phosphorylcholine; Reference Values; Synaptic Transmission | 1995 |
Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini.
Topics: Alkaloids; Animals; Calcimycin; Carbachol; Ceruletide; Cholecystokinin; Choline; Egtazic Acid; Enzyme Activation; Glycerophospholipids; In Vitro Techniques; Male; Pancreas; Phosphatidic Acids; Phospholipase D; Phosphorylcholine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1995 |
Incorporation of a phosphonium analogue of choline into the rat brain as measured by magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Choline; Choline Deficiency; Creatinine; Glycerylphosphorylcholine; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Weight; Myelin Sheath; Organophosphorus Compounds; Phosphatidylcholines; Phospholipids; Phosphorus Isotopes; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Tissue Extracts | 1995 |
Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha.
Topics: 3T3 Cells; Animals; Biological Transport; Blotting, Western; Carbon Radioisotopes; Choline; Dose-Response Relationship, Drug; Isoenzymes; Isotope Labeling; Mice; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
Insulin stimulates turnover of phosphatidylcholine in rat adipocytes.
Topics: Adipose Tissue; Animals; Choline; Epididymis; Hydrolysis; Insulin; Male; Membrane Lipids; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Signal Transduction | 1994 |
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Phosphorylcholine; Protein Kinase C; Rats; Rats, Inbred F344; Time Factors | 1995 |
Effect of insulin on SN-1,2-diacylglycerol species and de novo synthesis in rat skeletal muscle.
Topics: Animals; Choline; Diaphragm; Diglycerides; Ethers, Cyclic; Glucose; Insulin; Male; Muscle, Skeletal; Okadaic Acid; Phosphorylcholine; Rats; Rats, Wistar | 1995 |
Three-dimensional model of the human PAF receptor.
Topics: Amino Acid Sequence; Choline; Computer Simulation; Humans; Models, Molecular; Molecular Sequence Data; Phosphorylcholine; Platelet Membrane Glycoproteins; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver.
Topics: Animals; Body Weight; Choline; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Phosphorylcholine; Rats; Rats, Sprague-Dawley | 1994 |
In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells.
Topics: Animals; Carbon Isotopes; Cell Division; Choline; Ethanolamines; Glioma; Magnetic Resonance Spectroscopy; Methionine; Organophosphorus Compounds; Phosphatidylcholines; Phosphatidylserines; Phosphorus Isotopes; Phosphorylcholine; Rats; Rats, Inbred F344; S-Adenosylmethionine; Tumor Cells, Cultured | 1994 |
Rat lens choline and ethanolamine kinases: independent kinetics in intact tissue-competition in homogenates.
Topics: Animals; Choline; Choline Kinase; Ethanolamine; Ethanolamines; Eye; Kinetics; Organ Culture Techniques; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley | 1994 |
Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase.
Topics: Animals; Cell Line; Cholesterol; Cholesterol Esters; Choline; Choline-Phosphate Cytidylyltransferase; Hydroxycholesterols; Kinetics; Macrophages; Mice; Microscopy, Electron; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Transferases (Other Substituted Phosphate Groups); Tritium | 1994 |
Hydrolysis of exogenous [3H]phosphatidylcholine by brain membranes and cytosol.
Topics: Animals; Cell Membrane; Cerebral Cortex; Choline; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Kinetics; Lithium; Male; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Tritium; Type C Phospholipases | 1993 |
Characterization of choline metabolism and secretion by human placental trophoblasts in culture.
Topics: Betaine; Carbon Radioisotopes; Cells, Cultured; Choline; Culture Media; Humans; Phosphatidylcholines; Phosphorylcholine; Time Factors; Trophoblasts | 1993 |
The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio.
Topics: Animals; Betaine; Brain; Choline; Chromatography, High Pressure Liquid; Creatine; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Magnetic Resonance Spectroscopy; Microscopy, Electron; Phosphocreatine; Phosphorylcholine | 1993 |
Protein kinase C-dependent stimulation of phospholipase D in phospholipase C-treated fibroblasts.
Topics: 3T3 Cells; Animals; Choline; Dose-Response Relationship, Drug; Fibroblasts; Hydrolysis; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Digitonin; Diglycerides; Dogs; HeLa Cells; Humans; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of phospholipase activity during poliovirus infection.
Topics: Cadmium; Cell Membrane Permeability; Choline; HeLa Cells; Humans; Phosphatidylinositols; Phospholipases; Phosphorylcholine; Poliovirus; Quinacrine; Type C Phospholipases; Zinc | 1993 |
Activation of phospholipase D participates in signal transduction pathways responsive to gamma-radiation.
Topics: Carcinoma, Squamous Cell; Choline; Enzyme Activation; Gamma Rays; Glycerophospholipids; Glycerylphosphorylcholine; Head and Neck Neoplasms; Humans; Kinetics; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Signal Transduction; Tumor Cells, Cultured | 1993 |
Glycerophosphocholine and phosphocholine are the major choline metabolites in rat milk.
Topics: Animals; Betaine; Cells, Cultured; Choline; Chromatography, High Pressure Liquid; Epithelium; Female; Gas Chromatography-Mass Spectrometry; Glycerylphosphorylcholine; Lactation; Mammary Glands, Animal; Milk; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Sprague-Dawley | 1993 |
Efflux and hydrolysis of phosphorylethanolamine and phosphorylcholine in stressed cultured rat lenses.
Topics: Animals; Choline; Culture Techniques; Ethanolamines; Hydrolysis; Lens, Crystalline; Osmotic Pressure; Oxidation-Reduction; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Rose Bengal; Time Factors; Xylose | 1993 |
Effect of xylose on the synthesis of phosphorylcholine and phosphorylethanolamine in rat lenses.
Topics: Aminoisobutyric Acids; Animals; Biological Transport, Active; Choline; Choline Kinase; Ethanolamine; Ethanolamines; Lens, Crystalline; Organ Culture Techniques; Osmotic Pressure; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Xylose | 1993 |
Phospholipid synthesis in the lymphomatous mouse liver studied by 31P nuclear magnetic resonance spectroscopy in vitro and by administration of 14C-radiolabelled compounds in vivo.
Topics: Animals; Body Weight; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Liver Neoplasms; Lymphoma; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred A; Phosphatidylethanolamines; Phosphorylcholine; Tissue Extracts | 1993 |
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol.
Topics: Animals; Biological Transport; Calcium; Cell Line; Cell Membrane; Chelating Agents; Choline; Cricetinae; Cricetulus; Cytosol; Diglycerides; Egtazic Acid; Inositol Phosphates; Ionomycin; Isoenzymes; Kinetics; Phosphatidylcholines; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Alkylphosphocholines inhibit choline uptake and phosphatidylcholine biosynthesis in rat sympathetic neurons and impair axonal extension.
Topics: Animals; Animals, Newborn; Axons; Biological Transport; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Enzyme Inhibitors; Kinetics; Neurons; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate | 1995 |
Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.
Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Choline; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Inositol; Phospholipids; Phosphorylcholine; Tumor Cells, Cultured | 1995 |
Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.
Topics: Acetates; Acetic Acid; Biopsy; Brain; Choline; Edetic Acid; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Kinetics; Phosphoric Diester Hydrolases; Phosphorylcholine; Postmortem Changes; Temporal Lobe | 1995 |
In vivo 1H MRS choline: correlation with in vitro chemistry/histology.
Topics: Brain; Brain Neoplasms; Choline; Gas Chromatography-Mass Spectrometry; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Phosphorylcholine; Protons | 1996 |
Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Calcium; Cell Division; Choline; Enzyme Inhibitors; GTP-Binding Proteins; Inositol Phosphates; Mice; Osteoblasts; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Propranolol; Protein Kinase C; Signal Transduction; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Induction of resistance to hexadecylphosphocholine in the highly sensitive human epidermoid tumour cell line KB.
Topics: Antineoplastic Agents; Choline; Drug Resistance, Neoplasm; Humans; Inositol; KB Cells; Phospholipid Ethers; Phosphorylcholine | 1996 |
Electromagnetic field induced changes in lipid second messengers.
Topics: Cell Line; Choline; Diglycerides; Electromagnetic Fields; Enzyme Inhibitors; Ethanol; Flow Cytometry; Humans; Lipids; Molecular Structure; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Phospholipids; Phosphorylcholine; Propranolol; Pyrimidinones; Second Messenger Systems; Thiazoles; Time Factors; Tritium | 1996 |
Immortalization and transformation are associated with specific alterations in choline metabolism.
Topics: Animals; Antigens, Viral, Tumor; Cell Division; Cell Line, Transformed; Choline; Glioblastoma; Humans; Magnetic Resonance Spectroscopy; Meningioma; Neoplasms; Neuroblastoma; Phosphorylcholine; ras Proteins; Rats; Schwann Cells; Tumor Cells, Cultured | 1996 |
The choline content of human breast milk expressed during the first few weeks of lactation.
Topics: Choline; Female; Glycerylphosphorylcholine; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Lactation; Milk, Human; Nutritional Requirements; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Sphingomyelins; Time Factors | 1996 |
1H-magnetic resonance spectroscopic observation of cultured malignant cells pharmacologically induced to different phenotypes.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Butyrates; Butyric Acid; Choline; Creatine; Dexamethasone; Glutamic Acid; Glutamine; Histone Deacetylase Inhibitors; Humans; Hydrogen; Interferon-gamma; Lactates; Lung Neoplasms; Magnetic Resonance Spectroscopy; Phenotype; Phospholipids; Phosphorylcholine; Triglycerides; Tumor Cells, Cultured | 1996 |
Quantitation of glycerophosphorylcholine by flow injection analysis using immobilized enzymes.
Topics: Choline; Enzymes, Immobilized; Flow Injection Analysis; Glycerylphosphorylcholine; Humans; Hydrogen-Ion Concentration; Phosphoric Diester Hydrolases; Phosphorylcholine; Semen; Substrate Specificity | 1996 |
Direct proof that phorbol ester accelerates the use of choline phosphate for phosphatidylcholine synthesis in intact cells.
Topics: 3T3 Cells; Animals; Carbon Radioisotopes; Choline; Choline-Phosphate Cytidylyltransferase; Enzyme Inhibitors; Indoles; Kinetics; Maleimides; Mice; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Radioisotope Dilution Technique; Tetradecanoylphorbol Acetate | 1996 |
Stimulation of phospholipid synthesis in HeLa cells by epidermal growth factor and insulin: activation of choline kinase and glycerophosphate acyltransferase.
Topics: Choline; Choline Kinase; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epidermal Growth Factor; Ethanolamine; Ethanolamines; Glycerol; Glycerol-3-Phosphate O-Acyltransferase; HeLa Cells; Humans; Insulin; Phosphates; Phosphatidylcholines; Phospholipids; Phosphorylcholine | 1996 |
Complement activation in human serum by liposome-encapsulated hemoglobin: the role of natural anti-phospholipid antibodies.
Topics: Adenosine Triphosphate; Antibodies; Aspirin; Choline; Complement Activation; Complement System Proteins; Cross-Linking Reagents; Drug Compounding; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Humans; Immunoglobulin G; Immunoglobulin M; Liposomes; Phospholipids; Phosphorylcholine; Protein Binding | 1996 |
Progesterone triggers the rapid activation of phospholipase D in the amphibian oocyte plasma membrane when initiating the G2/M transition.
Topics: Animals; Bridged-Ring Compounds; Cell Cycle; Cell Membrane; Choline; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Estradiol; Norbornanes; Oocytes; Phosphatidate Phosphatase; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Progesterone; Rana pipiens; Sphingomyelins; Thiocarbamates; Thiones; Transferases (Other Substituted Phosphate Groups) | 1996 |
Proton MR spectroscopy of the normal human prostate with an endorectal coil and a double spin-echo pulse sequence.
Topics: Adult; Choline; Citrates; Creatine; Humans; Hydrogen; Image Enhancement; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phantoms, Imaging; Phosphorylcholine; Prostate; Protons; Rectum; Taurine; Water | 1997 |
Utilization of phosphocholine from extracellular complex polysaccharide as a source of cytoplasmic choline derivatives in Penicillium fellutanum.
Topics: Betaine; Carbohydrate Sequence; Choline; Culture Media; Galactose; Glycosaminoglycans; Hydrolases; Magnetic Resonance Spectroscopy; Mannans; Molecular Sequence Data; Penicillium; Phosphates; Phosphoric Monoester Hydrolases; Phosphorylcholine | 1997 |
Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae.
Topics: Adult; Amino Acid Sequence; Blood Bactericidal Activity; Choline; Haemophilus influenzae; Humans; Lipopolysaccharides; Molecular Sequence Data; Phosphorylcholine | 1997 |
sn-1,2-diacylglycerol and choline increase after fertilization in Xenopus laevis.
Topics: Animals; Biological Transport; Calcium; Cell Membrane; Choline; Diglycerides; Embryo, Nonmammalian; Female; Fertilization; Inositol 1,4,5-Trisphosphate; Insemination; Ionomycin; Male; Ovum; Phosphorylcholine; Protein Kinase C; Spermatozoa; Time Factors; Xenopus laevis; Zygote | 1997 |
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
Topics: 3T3 Cells; Animals; Bridged-Ring Compounds; Choline; Diglycerides; Enzyme Activation; Homeostasis; Inositol Phosphates; Interleukin-6; Kinetics; Lysophospholipids; Mice; Norbornanes; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase C; Sphingosine; Thiocarbamates; Thiones; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1997 |
The use of inhibitors of N-linked glycosylation and oligosaccharide processing to produce monoclonal antibodies against non-phosphorylcholine epitopes of Brugia pahangi excretory-secretory products.
Topics: 1-Deoxynojirimycin; Animals; Antibodies, Helminth; Antibodies, Monoclonal; Antigens, Helminth; Brugia pahangi; Choline; Epitopes, B-Lymphocyte; Gerbillinae; Glycosylation; Isotope Labeling; Oligosaccharides; Phosphorylcholine; Tritium; Tunicamycin | 1997 |
An in vitro 1H-MRS model of oncogene transfection. The spectral feature of c-erbB-2 and c-Ha-ras transfected NIH3T3 fibroblast cells.
Topics: 3T3 Cells; Animals; Cell Differentiation; Cell Division; Choline; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, ras; Glutamic Acid; Glutamine; Hydrogen; Magnetic Resonance Spectroscopy; Membrane Lipids; Mice; Oncogenes; Phosphatidylcholines; Phosphorylcholine; Spectrum Analysis; Transfection; Viscosity | 1997 |
The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Recombinant Proteins | 1998 |
Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells.
Topics: Calcium; Cell Survival; Cells, Cultured; Choline; Cytidine Diphosphate Choline; Cytosol; Humans; Hydroxycholesterols; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphorylcholine; Sphingomyelins | 1997 |
Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Count; Cell Differentiation; Cell Line; Cell Membrane; Cell Survival; Choline; Coloring Agents; Diffusion; Hydrocarbons; Hydrogen; Inositol; Lipid Metabolism; Lipids; Magnetic Resonance Spectroscopy; Membrane Lipids; Methane; Mice; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Triglycerides; Trypan Blue | 1998 |
Phase variation in colony opacity by Streptococcus pneumoniae.
Topics: Animals; Bacterial Capsules; Choline; Flow Cytometry; Fluorescent Antibody Technique; Humans; Mice; Nasopharynx; Phenotype; Phosphorylcholine; Pneumococcal Infections; Polysaccharides, Bacterial; Rats; Streptococcus pneumoniae | 1998 |
Active site of brain Zn2+-glycerophosphocholine cholinephosphodiesterase and regulation of enzyme activity.
Topics: Allosteric Regulation; Animals; Arginine; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Catalysis; Cations, Divalent; Cattle; Choline; Cysteine; Enzyme Activation; Glycerol; Hydrogen-Ion Concentration; Oxidation-Reduction; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Binding; Tetranitromethane; Zinc | 1998 |
Channelling of intermediates in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine in mammalian cells.
Topics: Animals; Bacterial Toxins; Calcium; Carbon Radioisotopes; Cell Line; Cell Membrane Permeability; Cells, Cultured; Choline; Fibroblasts; Hemolysin Proteins; Liver; Models, Biological; Multienzyme Complexes; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine; Rats | 1998 |
Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine.
Topics: Amino Acid Sequence; Bacteria; Bacterial Proteins; Base Sequence; Betaine; Cell Division; Choline; Cloning, Molecular; Conserved Sequence; Genes, Bacterial; Molecular Sequence Data; Osmotic Pressure; Phenotype; Phosphorylcholine; Sequence Alignment; Sequence Analysis, DNA; Sulfatases | 1998 |
Analysis of choline and phosphorylcholine content in human neutrophils stimulated by f-Met-Leu-Phe and phorbol myristate acetate: contribution of phospholipase D and C.
Topics: Choline; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidic Acids; Phospholipase D; Phosphorylcholine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
Chromatin-associated phosphatidylcholine synthesis.
Topics: Carbon Radioisotopes; Cell Nucleus; Choline; Chromatin; Cytidine Diphosphate Choline; Humans; Neuroblastoma; Phosphatidylcholines; Phosphorylcholine; Tumor Cells, Cultured | 1998 |
Sphingomyelin, glycosphingolipids and ceramide signalling in cells exposed to P-fimbriated Escherichia coli.
Topics: Ceramides; Choline; Chromatography, Thin Layer; Escherichia coli; Fimbriae, Bacterial; Galactose; Glycosphingolipids; Humans; Interleukin-1; Interleukin-6; Phosphorylcholine; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Urothelium | 1998 |
Increased synthesis of phosphocholine is required for UV-induced AP-1 activation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Choline; Choline Kinase; Enzyme Activation; Enzyme Inhibitors; Hemicholinium 3; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylcholine; Transcription Factor AP-1; Ultraviolet Rays | 1998 |
Choline derived from the phosphatidylcholine specific phospholipase D is not directly available for the CDP choline pathway in phorbol ester-treated C3H10T1/2 Cl 8 fibroblasts.
Topics: Animals; Cell Line; Choline; Cytidine Diphosphate Choline; Fibroblasts; Indoles; Maleimides; Mice; Mice, Inbred C3H; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Choline metabolism in breast cancer; 2H-, 13C- and 31P-NMR studies of cells and tumors.
Topics: Animals; Breast Neoplasms; Carbon Isotopes; Choline; Deuterium; Female; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nuclear Magnetic Resonance, Biomolecular; Phosphorus Isotopes; Phosphorylcholine; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Characterization of choline compounds with in vitro 1H magnetic resonance spectroscopy for the discrimination of primary brain tumors.
Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioma; Humans; In Vitro Techniques; Magnetic Resonance Imaging; Male; Middle Aged; Phosphorylcholine | 1999 |
Kinetic properties of purified Pseudomonas aeruginosa phosphorylcholine phosphatase indicated that this enzyme may be utilized by the bacteria to colonize in different environments.
Topics: Acid Phosphatase; Choline; Hydrogen-Ion Concentration; Phosphoric Monoester Hydrolases; Phosphorylcholine; Pseudomonas aeruginosa; Substrate Specificity | 1999 |
Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells.
Topics: Alkaloids; Apoptosis; Benzophenanthridines; Camptothecin; Choline; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Enzyme Inhibitors; Etoposide; Farnesol; Flow Cytometry; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Phenanthridines; Phosphatidylcholines; Phosphorylcholine | 1999 |
Antiphosphorylcholine antibody levels are elevated in humans with periodontal diseases.
Topics: Actinomycetales; Adult; Bacteria; Choline; Dental Plaque; Humans; Immunoglobulin G; Periodontal Diseases; Phosphorylcholine; Streptococcus; Tritium | 1999 |
Non-HPLC separation of water-soluble choline metabolites by two-dimensional high voltage electrophoresis and thin layer chromatography.
Topics: Choline; Choline Kinase; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis; Phosphorylcholine; Solubility; Tritium; Water | 1999 |
Changes in the choline content of human breast milk in the first 3 weeks after birth.
Topics: Adult; Choline; Colostrum; Female; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy; Milk, Human; Phosphorylcholine; Postpartum Period | 2000 |
Potential mechanisms of tumorigenic action of diethanolamine in mice.
Topics: Administration, Cutaneous; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Choline; Choline Deficiency; Diethylnitrosamine; Ethanolamines; Gastrointestinal Contents; Glycerylphosphorylcholine; Liver; Male; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine; Sodium Nitrite; Sphingomyelins | 2000 |
Phosphorylcholine decoration of lipopolysaccharide differentiates commensal Neisseriae from pathogenic strains: identification of licA-type genes in commensal Neisseriae.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; C-Reactive Protein; Choline; Culture Media; Epitopes; Genes, Bacterial; Lipopolysaccharides; Molecular Sequence Data; Neisseria; Phosphorylcholine | 2000 |
Phosphatidylcholine metabolism in human endothelial cells: modulation by phosphocholine.
Topics: Adenosine Triphosphate; Arachidonic Acid; Cells, Cultured; Choline; Endothelium, Vascular; Humans; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phosphorylcholine; Umbilical Veins | 2000 |
Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco.
Topics: Betaine; Biological Transport; Carbon Radioisotopes; Chloroplasts; Choline; Computer Simulation; Cytosol; Magnetic Resonance Spectroscopy; Nicotiana; Oxygenases; Phosphatidylcholines; Phosphorylation; Phosphorylcholine; Plants, Genetically Modified; Plants, Toxic; Vacuoles | 2000 |
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate Choline; Dinitrophenols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycerylphosphorylcholine; Membranes; Mitochondria; Neurons; PC12 Cells; Phosphatidylcholines; Phosphorylcholine; Rats; Sodium Azide; Time Factors; Uncoupling Agents | 2000 |
Phosphatidylcholine metabolism in nuclei of phorbol ester-activated LA-N-1 neuroblastoma cells.
Topics: Carbon Radioisotopes; Cell Nucleus; Choline; Choline Kinase; Cytidine Diphosphate Choline; Humans; Kinetics; Neuroblastoma; Palmitic Acid; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 2000 |
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Choline; Diglycerides; Enzyme Activation; Imidazoles; Imidazoline Receptors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Oxazoles; PC12 Cells; Phosphorylation; Phosphorylcholine; Rats; Receptors, Drug; Rilmenidine; Signal Transduction; Type C Phospholipases | 2001 |
Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy.
Topics: Adult; Biopsy; Brain Neoplasms; Choline; Glioblastoma; Gliosis; Humans; Lactates; Lipids; Magnetic Resonance Spectroscopy; Necrosis; Parietal Lobe; Phosphorylcholine; Protons | 2000 |
Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells.
Topics: Androgens; Cell Line; Cell Transformation, Neoplastic; Choline; Epithelial Cells; Humans; Male; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylcholines; Phosphorylcholine; Prostate; Prostatic Neoplasms; Receptors, Androgen | 2001 |
Choline deficiency induced by Mycoplasma fermentans enhances apoptosis of rat astrocytes.
Topics: Animals; Apoptosis; Astrocytes; Biological Transport, Active; Choline; Chromatography, Thin Layer; Culture Media; Cytidine Diphosphate Choline; Hot Temperature; Kinetics; Mycoplasma fermentans; Phosphorylcholine; Rats | 2001 |
Choline deficiency induces apoptosis in primary cultures of fetal neurons.
Topics: Animals; Apoptosis; Cell Membrane; Cells, Cultured; Ceramides; Cerebral Cortex; Choline; Choline Deficiency; Culture Media; Female; Hippocampus; In Situ Nick-End Labeling; Neurites; Neurons; PC12 Cells; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Rats; Rats, Sprague-Dawley | 2001 |
Hydrolysis of phosphotriesters: determination of transition states in parallel reactions by heavy-atom isotope effects.
Topics: Choline; Esters; Ethanol; Hydrolysis; Isotope Labeling; Kinetics; Nitro Compounds; Nitrogen Isotopes; Organophosphorus Compounds; Oxygen Isotopes; Phosphorylcholine | 2001 |
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Topics: Animals; Antineoplastic Agents; Choline; Drug Screening Assays, Antitumor; Humans; Male; Organophosphonates; Phosphorylcholine; Rats; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes.
Topics: Choline; Genetic Vectors; Nuclear Magnetic Resonance, Biomolecular; Phosphorylcholine; Transfection | 2001 |
Melanoma tumors acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumor samples.
Topics: Animals; Antineoplastic Agents; Cell Division; Choline; Ethanolamines; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorylcholine; Protons | 2002 |
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
Topics: Acetylcholine; Animals; Betaine; Cells, Cultured; Central Nervous System; Ceramides; Choline; Deanol; Diglycerides; Embryo, Mammalian; Embryonic and Fetal Development; Gastrula; Mice; Models, Neurological; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Sphingomyelins | 2002 |
Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis.
Topics: Betaine; Biomarkers, Tumor; Breast; Breast Neoplasms; Carbon Isotopes; Choline; Epithelial Cells; Humans; Lipid Metabolism; Membrane Transport Proteins; Nuclear Magnetic Resonance, Biomolecular; Phospholipid Ethers; Phospholipids; Phosphorus; Phosphorylcholine; Tumor Cells, Cultured | 2002 |
Genetic and functional analysis of the phosphorylcholine moiety of commensal Neisseria lipopolysaccharide.
Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Bacterial Adhesion; Cathelicidins; Choline; Epithelial Cells; Genes, Bacterial; Haemophilus influenzae; Humans; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neisseria; Phosphorylcholine; Sequence Homology, Amino Acid | 2002 |
Changes of plasma free choline and choline-containing compounds' concentrations and choline loss during hemodialysis in ESRD patients.
Topics: Adult; Choline; Choline Deficiency; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phosphatidylcholines; Phosphorylcholine; Renal Dialysis; Sphingomyelins | 2002 |
Investigation of the nature of potential phosphorylcholine donors for filarial nematode glycoconjugates.
Topics: Animals; Carbon Radioisotopes; Choline; Chromatography, High Pressure Liquid; Dipetalonema; Female; Glycoconjugates; Glycolipids; Helminth Proteins; Phosphatidylcholines; Phosphorylcholine; Spectrometry, Mass, Electrospray Ionization; Sphingomyelins | 2002 |
Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells.
Topics: Antineoplastic Agents; Cell Division; Choline; Humans; Phosphatidylcholines; Phosphorylcholine; Tumor Cells, Cultured | 2002 |
Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin.
Topics: Benzoquinones; Blotting, Western; Carbon Radioisotopes; Cell Division; Cell Survival; Choline; Humans; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphorylcholine; Quinones; Tumor Cells, Cultured | 2002 |
Inhibition of phosphatidylcholine synthesis is associated with excitotoxic cell death in cerebellar granule cell cultures.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Choline; Culture Media, Conditioned; Glucose; Glutamic Acid; Mitochondria; Neurons; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Tritium | 2002 |
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Dose-Response Relationship, Drug; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Mice; Mice, Knockout; Models, Biological; Oxidoreductases; Phosphorylcholine | 2003 |
Effect of exogenous surfactant on the development of surfactant synthesis in premature rabbit lung.
Topics: Animals; Biological Products; Carbon Radioisotopes; Choline; Drug Combinations; Fatty Alcohols; Female; Gene Expression Regulation, Developmental; Gestational Age; Glycerol; Lung; Organ Culture Techniques; Phospholipids; Phosphorylcholine; Polyethylene Glycols; Pregnancy; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rabbits; Tritium | 2003 |
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Diffusion; Ganciclovir; Genetic Therapy; Glioma; In Vitro Techniques; Lipid Metabolism; Magnetic Resonance Spectroscopy; Perchlorates; Phosphorylcholine; Rats; Taurine; Thymidine Kinase | 2003 |
Investigations of malignant tumours with radioactive phosphocholine.
Topics: Choline; Humans; Neoplasms; Phosphorylcholine; Radioactivity | 1953 |
[Formation of phosphorylcholine in the chemical hydrolysis of lecithins].
Topics: Choline; Hydrolysis; Lecithins; Phosphatidylcholines; Phosphorylcholine | 1954 |
Role of phosphorylcholine in acetylcholine synthesis.
Topics: Acetylcholine; Choline; Phosphorylcholine; Synaptic Transmission | 1956 |
Studies on the phosphorylcholine diesterase.
Topics: Choline; Humans; Liver; Phosphorylcholine | 1956 |
Glycerylphosphorylcholine and phosphorylcholine in semen, and their relation to choline.
Topics: Choline; Glycerylphosphorylcholine; Phosphorylcholine; Semen | 1957 |
Pharmacological properties of methyl-fluoro-phosphorylcholines; two synthetic cholinergic drugs.
Topics: Acetylcholine; Choline; Cholinergic Agents; Phosphorylcholine | 1957 |
The reported occurrence of sphingosylphosphorylcholine in animal tissues.
Topics: Animals; Choline; Phospholipids; Phosphorylcholine; Sphingosine | 1958 |
Further studies on fluoro-phosphorylcholines; pharmacological properties of two new analogues.
Topics: Choline; Cholinesterase Inhibitors; Inorganic Chemicals; Phosphorylcholine | 1958 |
[New phosphorylated esters of choline; chemical and pharmacological study; new method of preparation of phosphorylcholine].
Topics: Choline; Esters; Phosphorylcholine; Research | 1958 |
The action of choline and phosphorylcholine on liver oxidative processes.
Topics: Choline; Humans; Lecithins; Liver; Oxidation-Reduction; Phosphatidylcholines; Phosphorylcholine | 1961 |
[On the influence of phosphorylcholine on the choline content of the blood].
Topics: Choline; Humans; Lecithins; Phosphatidylcholines; Phosphorylcholine | 1963 |
Phosphorylcholine in rat tissues.
Topics: Animals; Choline; Phosphorylcholine; Rats | 1955 |
[Modifications induced by phosphorylcholine on the serological test of liver function in patients with pulmonary tuberculosis].
Topics: Choline; Liver; Liver Function Tests; Phosphates; Phosphorylcholine; Respiratory Physiological Phenomena; Serologic Tests; Tuberculosis; Tuberculosis, Pulmonary | 1960 |
[Biosynthesis of phospholipids in insects. I. Incorporation of phosphocholine-P32 into phospholipids in Celerio euphorbiae].
Topics: Animals; Choline; Insecta; Lipid Metabolism; Phosphates; Phospholipids; Phosphorylcholine | 1961 |
Influence of phosphorylcholine on endogenous oxidative phosphorylation of rat-liver mitochondria.
Topics: Animals; Choline; Liver; Metabolism; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Phosphorylcholine; Rats | 1962 |
Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3.
Topics: Animals; Ataxin-3; Brain; Cerebellum; Choline; Disease Models, Animal; gamma-Aminobutyric Acid; Glucose; Glutamine; Glycogen; Humans; Lactic Acid; Machado-Joseph Disease; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Phenotype; Phosphorylcholine; Repressor Proteins; Telencephalon; Transcription Factors; Trinucleotide Repeat Expansion | 2004 |
Synthesis and characterisation of cationically modified phospholipid polymers.
Topics: Biomimetic Materials; Cations; Choline; Coated Materials, Biocompatible; Macromolecular Substances; Materials Testing; Membranes, Artificial; Methacrylates; Molecular Conformation; Phospholipids; Phosphorylcholine; Polymers; Surface Properties; Water | 2004 |
A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion.
Topics: Albumins; Animals; Apolipoproteins B; Calnexin; Centrifugation, Density Gradient; Choline; Choline Deficiency; Culture Media; Cytidine Diphosphate Choline; Hepatocytes; Immunoblotting; Lipoproteins; Liver; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphorylcholine; Protein Disulfide-Isomerases; Time Factors; Triglycerides | 2004 |
Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice.
Topics: Administration, Topical; Animals; Betaine; Cells, Cultured; CHO Cells; Choline; Cricetinae; Cricetulus; Ethanolamines; Female; Liver; Mice; Mice, Inbred Strains; Phosphorylcholine; Rats; Rats, Inbred F344; Species Specificity; Tritium | 2004 |
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer.
Topics: Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cell Membrane; Choline; Choline Kinase; Humans; Mammary Glands, Human; Nuclear Magnetic Resonance, Biomolecular; Oligonucleotide Array Sequence Analysis; Phospholipids; Phosphorylcholine; Protons | 2004 |
On the importance of the phosphocholine methyl groups for sphingomyelin/cholesterol interactions in membranes: a study with ceramide phosphoethanolamine.
Topics: Animals; Anisotropy; Biophysics; Calcium; Chickens; Cholesterol; Choline; Diphenylhexatriene; Egg Yolk; Hot Temperature; Hydrogen Bonding; Hydrolysis; Kinetics; Lipid Bilayers; Macromolecular Substances; Membranes; Microscopy, Fluorescence; Phosphorylcholine; Sphingolipids; Sphingomyelins; Sterols; Streptomyces; Temperature | 2005 |
Interaction between ferric ions, phospholipid hydroperoxides, and the lipid phosphate moiety at physiological pH.
Topics: Arachidonic Acid; Catalysis; Choline; Fatty Acids; Hydrogen-Ion Concentration; Ions; Iron; Lipid Peroxidation; Lipid Peroxides; Magnetic Resonance Spectroscopy; Phosphates; Phospholipids; Phosphorylcholine | 2004 |
Proton-decoupled 31P MRS in untreated pediatric brain tumors.
Topics: Brain; Brain Neoplasms; Case-Control Studies; Child; Choline; Creatine; Ethanolamines; Female; Glycerylphosphorylcholine; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Phosphatidylethanolamines; Phosphorylcholine | 2005 |
Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline.
Topics: Cell Line, Tumor; Choline; Colonic Neoplasms; Gene Deletion; Genes, p53; Humans; Mutation; Phosphorylcholine | 2004 |
Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk.
Topics: Adult; Breast Feeding; Child; Child, Preschool; Choline; Female; Glycerylphosphorylcholine; Humans; Infant; Infant, Newborn; Lactation; Male; Milk, Human; Phosphatidylcholines; Phosphorylcholine; Sphingomyelins | 2005 |
Alterations of choline phospholipid metabolism in ovarian tumor progression.
Topics: Carbon Radioisotopes; Cell Line, Tumor; Choline; Choline Kinase; Disease Progression; Female; Humans; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Type C Phospholipases | 2005 |
Chemical knockout of C-reactive protein in cardiovascular disease.
Topics: Animals; C-Reactive Protein; Cardiovascular Diseases; Choline; Hexanes; Humans; Molecular Structure; Molecular Weight; Phosphorylcholine; Rats | 2006 |
Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Caenorhabditis elegans Proteins; Choline; Choline Kinase; Crystallography, X-Ray; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Phosphorylcholine; Protein Conformation; Sequence Homology, Amino Acid; Substrate Specificity | 2006 |
Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells.
Topics: Animals; Apoptosis; Brain; Bromodeoxyuridine; Carbon Radioisotopes; Cell Proliferation; Cells, Cultured; Choline; Choline Kinase; DNA Fragmentation; Dose-Response Relationship, Drug; Ethanolamines; Female; In Situ Nick-End Labeling; Intracellular Fluid; Mice; Mice, Inbred C57BL; Neurons; Phosphorylation; Phosphorylcholine; Pregnancy; Stem Cells; Time Factors | 2007 |
Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus.
Topics: Amino Acids; Animals; Choline; Diet; DNA Methylation; Female; Fetus; Folic Acid; Folic Acid Deficiency; Liver; Maternal-Fetal Exchange; Metabolic Networks and Pathways; Methionine; Phosphorylcholine; Pregnancy; Pregnancy Complications; Rats; Weight Gain | 2007 |
Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system.
Topics: Adrenal Glands; Adrenalectomy; Animals; Aorta, Thoracic; Autonomic Nervous System; Blood Pressure; Catecholamines; Choline; Cytidine; Cytidine Diphosphate Choline; Cytidine Monophosphate; Heart Atria; Heart Rate; In Vitro Techniques; Male; Nootropic Agents; Parasympathetic Nervous System; Peripheral Nerves; Phosphorylcholine; Rats; Rats, Wistar; Renin; Sympathectomy, Chemical; Vasopressins | 2007 |
Choline kinase alpha in cancer prognosis and treatment.
Topics: Carcinoma, Non-Small-Cell Lung; Choline; Choline Kinase; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Phosphorylcholine; Prognosis; RNA, Messenger | 2007 |
Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Choline; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Female; Insulin; Insulin Secretion; Islets of Langerhans; Nicotinic Antagonists; Phosphorylcholine; Rats; Rats, Wistar; Reaction Time; Receptors, Adrenergic, alpha; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission; Up-Regulation | 2008 |
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.
Topics: Adrenal Glands; Animals; Atropine Derivatives; Autonomic Nervous System; Central Nervous System; Choline; Cytidine; Cytidine Diphosphate Choline; Cytidine Monophosphate; Disease Models, Animal; Dose-Response Relationship, Drug; Epinephrine; Female; Hemorrhage; Hexamethonium; Injections, Intraperitoneal; Injections, Intraventricular; Mecamylamine; Nicotinic Antagonists; Norepinephrine; Phosphorylcholine; Rats; Rats, Wistar; Time Factors | 2008 |
Comparison of radiolabeled choline and ethanolamine as probe for cancer detection.
Topics: Carbon Radioisotopes; Cell Line, Tumor; Choline; Ethanolamine; Ethanolamines; Fibroblasts; Fluorine Radioisotopes; Humans; Magnetic Resonance Spectroscopy; Neoplasms; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine; Positron-Emission Tomography; Radiopharmaceuticals | 2008 |
Therapeutic target metabolism observed using hyperpolarized 15N choline.
Topics: Choline; Choline Kinase; Humans; Kinetics; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphorylcholine | 2008 |
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Choline; Choline Kinase; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glycerylphosphorylcholine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Magnetic Resonance, Biomolecular; Oligonucleotide Array Sequence Analysis; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Prostate; Prostatic Neoplasms; Protons | 2008 |
Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system.
Topics: Adrenal Medulla; Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Brain; Choline; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Ganglionic Blockers; Glucagon; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Antagonists; Neurotransmitter Uptake Inhibitors; Nicotinic Antagonists; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Time Factors; Up-Regulation | 2008 |
Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy.
Topics: Choline; Ethanolamine; Ethanolamines; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorylcholine; Prostate; Prostatic Neoplasms | 2008 |
GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites.
Topics: Animals; AraC Transcription Factor; Betaine; Choline; DNA Mutational Analysis; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Bacterial; Male; Mice; Mice, Inbred C57BL; Phosphoric Monoester Hydrolases; Phosphorylcholine; Promoter Regions, Genetic; Pseudomonas aeruginosa; Pseudomonas Infections; Reverse Transcriptase Polymerase Chain Reaction; Sarcosine; Transcription, Genetic; Transferases (Other Substituted Phosphate Groups) | 2009 |
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Topics: Animals; Behavior, Animal; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Choline; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Huntington Disease; Lactic Acid; Male; Metabolomics; Nitro Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphorylcholine; Propionates; Rats; Rats, Sprague-Dawley; Succinic Acid; Taurine | 2009 |
Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Female; Frontal Lobe; Functional Laterality; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorylcholine; Psychiatric Status Rating Scales; Severity of Illness Index | 2009 |
Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts.
Topics: Animals; Biomarkers, Tumor; Blotting, Western; Cell Line; Cell Line, Tumor; Choline; Chromones; Embryonal Carcinoma Stem Cells; Embryonic Stem Cells; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mice; Morpholines; Octamer Transcription Factor-3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylcholine; Pluripotent Stem Cells; Proto-Oncogene Proteins c-akt; Signal Transduction | 2009 |
Phosphorylcholine.
Topics: Choline; Phosphorylcholine | 1947 |
Total choline at 1H-MRS and [18F]-fluoromethylcholine uptake at PET.
Topics: Animals; Cell Line, Tumor; Choline; Fluorine Radioisotopes; Humans; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Phosphorylcholine; Positron-Emission Tomography; Rats | 2010 |
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.
Topics: Adenocarcinoma; Cell Line, Tumor; Choline; Choline Kinase; Down-Regulation; Furans; HCT116 Cells; Humans; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylcholine; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyridines; Pyrimidines | 2010 |
Investigation of toxicological effects of Shuanghuanglian injection in Beagle dogs by metabonomic and traditional approaches.
Topics: Anemia, Hemolytic; Animals; Biomarkers; Body Weight; Choline; Dogs; Drugs, Chinese Herbal; Injections, Intravenous; Kidney; Lactic Acid; Liver; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Organ Size; Phosphorylcholine; Serum; Spleen; Taurine | 2010 |
Choline catabolism, σ⁵⁴ factor and NtrC are required for the full expression of the Pseudomonas aeruginosa phosphorylcholine phosphatase gene.
Topics: Base Sequence; Choline; Gene Expression; Gene Expression Regulation, Bacterial; Gene Order; Genes, Bacterial; Molecular Sequence Data; Phosphoric Monoester Hydrolases; Phosphorylcholine; Promoter Regions, Genetic; Pseudomonas aeruginosa; RNA Polymerase Sigma 54; Sequence Deletion; Transcription Factors | 2011 |
17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2.
Topics: Antigens, CD; Antineoplastic Agents; Benzoquinones; Biological Transport; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Choline; Female; Gene Expression Regulation, Neoplastic; Glycerylphosphorylcholine; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Magnetic Resonance Spectroscopy; MCF-7 Cells; Membrane Transport Proteins; Organic Cation Transport Proteins; Phospholipases A2; Phosphorylcholine | 2010 |
Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models.
Topics: Animals; Breast Neoplasms; Choline; Female; Glycerylphosphorylcholine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Mice; Mice, SCID; Molecular Dynamics Simulation; Neoplasm Metastasis; Phosphorylcholine; Principal Component Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transplantation, Heterologous | 2010 |
A selective NMR method for detecting choline containing compounds in liver tissue: the 1H-14N HSQC experiment.
Topics: Animals; Choline; Liver; Magnetic Resonance Spectroscopy; Mice; Phosphorylcholine | 2010 |
Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
Topics: Cell Line, Tumor; Choline; Culture Media; Epithelium; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lipid Metabolism; Male; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasms, Glandular and Epithelial; Phosphorylation; Phosphorylcholine; Prostate; Prostatic Neoplasms; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate | 2011 |
Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice.
Topics: Aging; Animals; Anthocyanins; Blueberry Plants; Brain Chemistry; Choline; Fruit; Galactosides; gamma-Aminobutyric Acid; Glutamic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Phosphorylcholine; Plant Extracts; Taurine | 2011 |
Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Choline; Choline Kinase; Cyclooxygenase 2; Female; Gene Knockdown Techniques; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasm Invasiveness; Phospholipids; Phosphorylcholine | 2012 |
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Female; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2012 |
Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.
Topics: Animals; Choline; Cysteine; Diet; Female; Fetus; Folic Acid; Homocysteine; Kinetics; Litter Size; Liver; Methionine; Methylation; Pancreas; Phosphorylcholine; Placenta; Pregnancy; Rats; Triglycerides; Weight Gain | 2012 |
Translational regulation of Arabidopsis XIPOTL1 is modulated by phosphocholine levels via the phylogenetically conserved upstream open reading frame 30.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Choline; DNA, Plant; Gene Expression Regulation, Plant; In Situ Nick-End Labeling; Methyltransferases; Molecular Sequence Data; Open Reading Frames; Phosphorylcholine; Point Mutation | 2012 |
The structural domains of Pseudomonas aeruginosa phosphorylcholine phosphatase cooperate in substrate hydrolysis: 3D structure and enzymatic mechanism.
Topics: Binding Sites; Biocatalysis; Catalytic Domain; Choline; Crystallography, X-Ray; Hydrolases; Models, Molecular; Mutagenesis, Site-Directed; Phosphorylcholine; Protein Folding; Protein Structure, Tertiary; Pseudomonas aeruginosa; Tromethamine; Type C Phospholipases | 2012 |
Choline intake and risk of lethal prostate cancer: incidence and survival.
Topics: Adult; Aged; Betaine; Choline; Cohort Studies; Diet; Disease Progression; Follow-Up Studies; Health Personnel; Humans; Incidence; Male; Middle Aged; Phosphatidylcholines; Phosphorylcholine; Prospective Studies; Prostatic Neoplasms; Risk; Sphingomyelins; Survival Analysis; United States | 2012 |
Prevention of schizophrenia: an impossible dream?
Topics: Attention; Brain; Choline; Female; Humans; Male; Neural Inhibition; Nootropic Agents; Phosphorylcholine; Pregnancy; Schizophrenia; Sensory Gating | 2013 |
HDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Choline; Enzyme Activation; Female; Gene Expression Regulation; Glycerylphosphorylcholine; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Magnetic Resonance Spectroscopy; MCF-7 Cells; Phosphorylcholine; Vorinostat | 2013 |
Metabolic changes in psoriatic skin under topical corticosteroid treatment.
Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Aged; Biomarkers; Biopsy; Choline; Female; Glucose; Glycine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorylcholine; Psoriasis; Skin | 2013 |
Absolute quantification of choline-related biomarkers in breast cancer biopsies by liquid chromatography electrospray ionization mass spectrometry.
Topics: Acetonitriles; Biomarkers, Tumor; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Choline; Chromatography, Liquid; Female; Glycerylphosphorylcholine; Humans; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Phosphorylcholine; Solvents; Spectrometry, Mass, Electrospray Ionization | 2013 |
Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer.
Topics: Carcinoma, Ovarian Epithelial; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Choline; Choline Kinase; Down-Regulation; Doxorubicin; Female; Humans; Lipid Metabolism; Molecular Targeted Therapy; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Phosphorylcholine; Platinum; RNA Interference; Signal Transduction; Transcriptome | 2014 |
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Choline; Choline Kinase; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycerylphosphorylcholine; Humans; Metabolomics; Mice; Neoplasm Transplantation; Phosphoric Diester Hydrolases; Phosphorylcholine; Tissue Array Analysis; Transcriptome; Transplantation, Heterologous | 2014 |
Mapping of glycine distributions in gliomas.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Choline; Diffusion Magnetic Resonance Imaging; Glioblastoma; Glycine; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Neoplasm Grading; Phosphorylcholine; Retrospective Studies; Young Adult | 2014 |
Amino acid anions in organic ionic compounds. An ab initio study of selected ion pairs.
Topics: Amino Acids; Anions; Cations; Choline; Gases; Ionic Liquids; Molecular Dynamics Simulation; Phosphorylcholine; Protons; Thermodynamics | 2014 |
Influence of calcium on choline measurements by 1H MR spectroscopy of thigh muscles.
Topics: Aged, 80 and over; Cadaver; Calcium Carbonate; Choline; Female; Humans; Longitudinal Studies; Magnetic Fields; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Muscle, Skeletal; Phosphorylcholine; Protons; Thigh | 2014 |
Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.
Topics: Adenocarcinoma; Cell Line; Cell Line, Tumor; Choline; Choline Kinase; Endometrial Neoplasms; Female; Humans; Hyperplasia; Lipid Metabolism; Middle Aged; Phospholipases; Phospholipids; Phosphorylcholine; Signal Transduction; Thiolester Hydrolases | 2014 |
Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells.
Topics: Alkynes; Amino Acid Sequence; Amino Acid Transport Systems; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chlorocebus aethiops; Choline; COS Cells; Glycoproteins; Ion Pumps; Molecular Probes; Molecular Sequence Data; Phosphorylcholine; Staining and Labeling | 2015 |
Choline Alleviates Parenteral Nutrition-Associated Duodenal Motility Disorder in Infant Rats.
Topics: Animals; Animals, Newborn; Betaine; Choline; Disease Models, Animal; Duodenum; Gastrointestinal Motility; Intestinal Diseases; Male; Oxidative Stress; Parenteral Nutrition; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Tumor Necrosis Factor-alpha | 2016 |
Micelle-Triggered β-Hairpin to α-Helix Transition in a 14-Residue Peptide from a Choline-Binding Repeat of the Pneumococcal Autolysin LytA.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Choline; Circular Dichroism; Humans; Micelles; Models, Molecular; N-Acetylmuramoyl-L-alanine Amidase; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphorylcholine; Pneumococcal Infections; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Streptococcus pneumoniae; Surface-Active Agents; Trifluoroethanol | 2015 |
Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig.
Topics: Animals; Animals, Newborn; Brain; Choline; Choline Deficiency; Diet; Diffusion Tensor Imaging; Disease Models, Animal; Female; Fetal Development; Fetal Growth Retardation; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Maternal Nutritional Physiological Phenomena; Neurogenesis; Neuroimaging; Organ Size; Phosphatidylcholines; Phosphorylcholine; Pregnancy; Sus scrofa | 2016 |
Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.
Topics: Acetylcholine; Adenosine Triphosphate; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Cells, Cultured; Choline; Dose-Response Relationship, Drug; Humans; Interleukin-1beta; Lipopolysaccharides; Membrane Potentials; Monocytes; Nicotine; Nicotinic Agonists; Phosphorylcholine; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; U937 Cells | 2015 |
Unique choline-containing phosphoglycolipids in Mycoplasma fermentans.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Astrocytes; Calcium-Binding Proteins; Choline; Fatty Acids, Nonesterified; Humans; Immune System; Mycoplasma fermentans; Phosphorylcholine; Rats | 2015 |
Metabolite profiling in retinoblastoma identifies novel clinicopathological subgroups.
Topics: Adolescent; Adult; Aged, 80 and over; Cell Differentiation; Child; Choline; Creatine; Female; Humans; Magnetic Resonance Imaging; Male; Metabolome; Middle Aged; Phosphorylcholine; Principal Component Analysis; Retinoblastoma; Taurine; Young Adult | 2015 |
Haemophilus influenzae LicB contributes to lung damage in an aged mice co-infection model.
Topics: Age Factors; Amino Acid Sequence; Animals; Bacterial Proteins; Choline; Coinfection; Disease Models, Animal; Haemophilus Infections; Haemophilus influenzae; Influenza A virus; Lipopolysaccharides; Lung; Membrane Transport Proteins; Mice; Mutation; Orthomyxoviridae Infections; Phosphorylcholine; Transcription Factor CHOP; Virulence | 2016 |
Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis.
Topics: Animals; Binding Sites; Calcium; Carrier Proteins; Cell Wall; Choline; Crystallography, X-Ray; Female; Immune Evasion; Mice; Models, Molecular; Nasopharynx; Phagocytes; Phosphorylcholine; Pneumococcal Infections; Respiratory Tract Infections; Streptococcus pneumoniae; Teichoic Acids; Virulence | 2016 |
Sample Preparation of Corn Seed Tissue to Prevent Analyte Relocations for Mass Spectrometry Imaging.
Topics: Choline; Equipment Design; Palmitic Acid; Phosphorylcholine; Seeds; Spectrometry, Mass, Secondary Ion; Zea mays | 2017 |
Biomimetic Polymer-Based Method for Selective Capture of C-Reactive Protein in Biological Fluids.
Topics: Acrylamides; Adsorption; Animals; Biomimetic Materials; C-Reactive Protein; Choline; Humans; Phosphorylcholine; Rats | 2018 |
Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy.
Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Blood-Brain Barrier; Brain; Brain Neoplasms; Central Nervous System; Choline; Cross-Linking Reagents; Drug Liberation; Humans; Immunotherapy; Male; Mice, Inbred BALB C; Nanocapsules; Particle Size; Permeability; Phosphorylcholine | 2019 |
Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Survival; Choline; Choline Kinase; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Knockout; Multiple Myeloma; Mutation; Phosphorylcholine; Signal Transduction; TNF Receptor-Associated Factor 3 | 2020 |
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Atherosclerosis; Cardiovascular Diseases; Chimera; Cholesterol, LDL; Choline; Disease Models, Animal; Female; Immunoglobulin G; Macaca fascicularis; Macrophages; Male; Mice, Inbred C57BL; Oxidation-Reduction; Phosphorylcholine; Rats | 2021 |
A Crosstalk- and Interferent-Free Dual Electrode Amperometric Biosensor for the Simultaneous Determination of Choline and Phosphocholine.
Topics: Biosensing Techniques; Choline; Electrodes; Enzymes, Immobilized; Phosphorylcholine; Polymers; Pyrroles | 2021 |
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum.
Topics: Carboxy-Lyases; Choline; Erythrocytes; Gene Expression Regulation; Gene Knockdown Techniques; Genes, Reporter; Green Fluorescent Proteins; Homeostasis; Humans; Life Cycle Stages; Lipid Metabolism; Lysophosphatidylcholines; Lysophospholipase; Methyltransferases; Phosphatidylcholines; Phosphorylcholine; Plasmodium falciparum; Protozoan Proteins; S-Adenosylmethionine; Serine | 2021 |
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification.
Topics: Choline; Cryoelectron Microscopy; Lipopolysaccharides; Membrane Transport Proteins; Phosphorylcholine; Streptococcus pneumoniae; Teichoic Acids | 2022 |
Polylactic acid film surface functionalized by zwitterionic poly[2-(methacryloyloxy)ethyl choline phosphate] with improved biocompatibility.
Topics: Choline; Phosphates; Phosphorylcholine; Polyesters; Surface Properties | 2022 |
Breast Tissue Chemistry Measured In Vivo In Healthy Women Correlate with Breast Density and Breast Cancer Risk.
Topics: Breast Density; Breast Neoplasms; Choline; Female; Glucose; Glutamates; Glutamine; Humans; Lipids; Mammography; Phosphorylcholine; Prospective Studies; Risk Factors; Sterols; Taurine | 2022 |
Metabolic Labeling-Based Chemoproteomics Establishes Choline Metabolites as Protein Function Modulators.
Topics: Animals; Antineoplastic Agents; Choline; Humans; Mammals; Neoplasms; Phosphorylcholine; Proteome | 2022 |
Effects of dietary branched-chain amino acid supplementation on serum and milk metabolome profiles in dairy cows during early lactation.
Topics: Amino Acids, Branched-Chain; Animals; Antioxidants; Carnitine; Cattle; Choline; Diet; Dietary Supplements; Fatty Acids; Female; Glucose; Glutathione; Humans; Insulins; Lactation; Lipids; Metabolome; Milk; Nitrogen; Phosphorylcholine; Urea | 2022 |
Twist alters the breast tumor microenvironment via choline kinase to facilitate an aggressive phenotype.
Topics: Cell Line, Tumor; Choline; Choline Kinase; Phenotype; Phosphorylcholine; Tumor Microenvironment; Twist-Related Protein 1 | 2023 |
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
Topics: Carbonyl Reductase (NADPH); Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Choline; Choline Kinase; Down-Regulation; Female; Glycerylphosphorylcholine; Humans; NAD; NADP; Ovarian Neoplasms; Oxidoreductases; Phosphorylcholine; Proto-Oncogene Proteins c-akt | 2022 |
Light effects on Lasiodiplodia theobromae metabolome cultured in vitro.
Topics: Betaine; Choline; Isoleucine; Leucine; Metabolome; Metabolomics; Phosphorylcholine; Valine | 2023 |