phosphorus-radioisotopes has been researched along with lexitropsin* in 1 studies
1 other study(ies) available for phosphorus-radioisotopes and lexitropsin
| Article | Year |
|---|---|
Control over the sequence specificity of DNA alkylation: syntheses and reactions with 32P-end-labelled DNA of N-alkyl-N-nitrosoureas linked to minor groove binding lexitropsins.
The syntheses of N-2-chloroethyl-N-nitrosoureas (Cl-ENU) that are covalently linked to a series of minor groove binding lexitropsins related to distamycin A are reported. The lexitropsins of 2-Cl-ENU show a sequence specificity for alkylating an adenine toward the ends of its DNA affinity binding domains. The reaction of DNA with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea does not yield these products. Therefore, the linking of the 2-Cl-ENU to the minor groove binder qualitatively and quantitatively alters the DNA observed. Topics: Alkylation; Antineoplastic Agents; Base Sequence; DNA; Molecular Sequence Data; Netropsin; Nitrosourea Compounds; Phosphorus Radioisotopes | 1991 |