phosphorus-radioisotopes and 2-hydroxyamino-1-methyl-6-phenylimidazo(4-5-b)pyridine

phosphorus-radioisotopes has been researched along with 2-hydroxyamino-1-methyl-6-phenylimidazo(4-5-b)pyridine* in 1 studies

Other Studies

1 other study(ies) available for phosphorus-radioisotopes and 2-hydroxyamino-1-methyl-6-phenylimidazo(4-5-b)pyridine

Article	Year
Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters. Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:10 We examined the reactivity of the N-hydroxyamino derivative of a carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), after its O-acetylation with four 2'-deoxyribonucleoside 3'-monophosphates. 32P-Postlabeling analysis demonstrated that the levels of adducts with 2'-deoxyguanosine 3'-monophosphate were much higher than those with the other three nucleotides. 1H-NMR, mass spectral and UV absorption spectral analyses of the major adducts formed by N-acetyoxy-PhIP with 2'-deoxyguanosine and with its phosphate esters indicated that PhIP bound at the C-8 position of guanine, as previously demonstrated with other heterocyclic amines. Topics: Acetic Anhydrides; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Deoxyguanosine; Guanine; Imidazoles; Isotope Labeling; Magnetic Resonance Spectroscopy; Mutagens; Nucleotides; Phosphates; Phosphorus Radioisotopes; Pyridines; Spectrometry, Mass, Fast Atom Bombardment	1992

Article

Year

Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.

Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:10

We examined the reactivity of the N-hydroxyamino derivative of a carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), after its O-acetylation with four 2'-deoxyribonucleoside 3'-monophosphates. 32P-Postlabeling analysis demonstrated that the levels of adducts with 2'-deoxyguanosine 3'-monophosphate were much higher than those with the other three nucleotides. 1H-NMR, mass spectral and UV absorption spectral analyses of the major adducts formed by N-acetyoxy-PhIP with 2'-deoxyguanosine and with its phosphate esters indicated that PhIP bound at the C-8 position of guanine, as previously demonstrated with other heterocyclic amines.

Topics: Acetic Anhydrides; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Deoxyguanosine; Guanine; Imidazoles; Isotope Labeling; Magnetic Resonance Spectroscopy; Mutagens; Nucleotides; Phosphates; Phosphorus Radioisotopes; Pyridines; Spectrometry, Mass, Fast Atom Bombardment

1992