phosphoribosyl pyrophosphate has been researched along with orotic acid in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (70.59) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banholzer, P; Gröbner, W; Zöllner, N | 1 |
| Burk, L; Fox, IH; Goren, M; Kaminska, J; Planet, G | 1 |
| Greenberg, LB; Sloan, DL; Victor, J | 1 |
| Astrin, K; Brenton, D; Cruikshank, M; Lever, J; Nuki, G; Seegmiller, JE | 1 |
| Schretlen, ED; Tax, WJ; Veerkamp, JH | 1 |
| Hashmi, S; Krooth, RS; May, SR; Miller, OJ | 1 |
| Cox, RP; Holland, MJ; Klein, NC | 1 |
| Gröbner, W; Zöllner, N | 1 |
| Gorbach, ZV; Ostrovskiĭ, IuM | 1 |
| Guganig, ME; Reyes, P | 1 |
| Colofiore, JR; Koutcher, JA; Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Fukuda, Y; Kimura, A; Murata, K; Shimosaka, M | 1 |
| Fairbanks, LD; Simmonds, HA; Webster, DR | 1 |
| Behrens, ND; Hupe, DJ | 1 |
| Harden, KK; Robinson, JL | 1 |
| Balis, ME; Colofiore, JR; Martin, DS; Sawyer, RC | 1 |
| Cortes, P; Levin, NW; Schoenberger, AM; Venkatachalam, KK; Verghese, CP | 1 |
| Jack, I; Parker, NF; Van Der Weyden, MB | 1 |
| Glasgow, AM | 1 |
| Kato, H; Patterson, D; Rumsby, PC; Waldren, CA | 1 |
| Dileepan, KN; Kennedy, J | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Gutteridge, WE; Hammond, DJ | 1 |
| Boer, P; Jerushalmy, Z; Patya, M; Sperling, O | 1 |
| Grubmeyer, C; Ozturk, DH; Sacchettini, JC; Scapin, G | 1 |
| Dorfman, RH; Grubmeyer, C; Ozturk, DH; Sacchettini, JC; Scapin, G | 1 |
| Bhatia, MB; Grubmeyer, C | 1 |
| Fujio, T; Maruyama, A | 1 |
| Fujio, T; Maruyama, A; Teshiba, S | 1 |
| Zimmer, HG | 1 |
| Hamana, H; Shinozawa, T | 1 |
| TARR, HL | 1 |
| Ma, C; Wang, X; Xu, P | 1 |
| Almo, SC; Fedorov, AA; Grubmeyer, C; Hansen, MR | 1 |
2 review(s) available for phosphoribosyl pyrophosphate and orotic acid
| Article | Year |
|---|---|
[Disorders of human pyrimidine metabolism (author's transl)].
Topics: Allopurinol; Azauridine; Chemical Phenomena; Chemistry; Cytidine; Folic Acid; Humans; Infant; Male; Ornithine Carbamoyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidine Nucleotides; Pyrimidines; Uridine | 1975 |
Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats.
Topics: Adenine; Animals; Inosine; Myocardium; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Ribose | 1998 |
32 other study(ies) available for phosphoribosyl pyrophosphate and orotic acid
| Article | Year |
|---|---|
Effect of allopurinol on pyrimidine metabolism in human white blood cells. Role of the salvage pathway.
Topics: Allopurinol; Humans; Leukocytes; Orotic Acid; Oxypurinol; Phosphoribosyl Pyrophosphate; Uridine | 1979 |
Pyrimidine nucleotide biosynthesis. A study of normal and purine enzyme-deficient cells.
Topics: Adenosine; Adolescent; Erythrocytes; Fibroblasts; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Male; Orotic Acid; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Purine-Nucleoside Phosphorylase; Pyrimidine Nucleotides | 1978 |
Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast.
Topics: Diphosphates; Kinetics; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Ribonucleotides; Saccharomyces cerevisiae | 1979 |
Purine and pyrimidine nucleotides in some mutant human lymphoblasts.
Topics: Adenine Nucleotides; Bicarbonates; Guanine Nucleotides; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Lymphocytes; Male; Mutation; Orotic Acid; Phosphates; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides | 1977 |
The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay.
Topics: Adolescent; Adult; Aging; Allopurinol; Breast Feeding; Child; Female; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Infant, Newborn; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Pregnancy; Radioisotope Dilution Technique; Uridine | 1978 |
Increased intracellular phosphoribosylpyrophosphate and accelerated orotic acid decarboxylation in a mouse cell line resistant to purine and pyrimidine ribonucleosides.
Topics: Adenine Phosphoribosyltransferase; Cell Line; Hypoxanthine Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purine-Nucleoside Phosphorylase; Ribonucleosides; Uridine Kinase | 1977 |
Experimental modulation of PRPP availability for ribonucleotide synthesis from hypoxanthine in human skin fibroblast cultures.
Topics: Adenine; Adenosine; Cell Line; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetics; Methylene Blue; Orotic Acid; Pentosephosphates; Phosphoribosyl Pyrophosphate; Ribonucleotides | 1978 |
[Possible mechanism of action of oxythiamine on nucleic acid metabolism].
Topics: Animals; DNA; Liver; Orotic Acid; Oxythiamine; Phosphoribosyl Pyrophosphate; Rats; RNA; Thiazoles; Transketolase | 1977 |
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Carboxylic Acids; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Hot Temperature; Kinetics; Leukemia, Experimental; Mice; Orotic Acid; Pentosyltransferases; Peptide Hydrolases; Phosphoribosyl Pyrophosphate; Pyrimidines; Uracil; Uracil Nucleotides; Uridine Phosphorylase | 1975 |
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Orotic Acid; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1992 |
Purification and properties of orotate phosphoribosyltransferases from Escherichia coli K-12, and its derivative purine-sensitive mutant.
Topics: Bacterial Proteins; Diphosphates; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Molecular Weight; Nucleosides; Nucleotides; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Sulfhydryl Reagents | 1985 |
Usefulness of intact erythrocyte studies in the diagnosis of inherited purine and pyrimidine defects.
Topics: Adenine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocytes; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine-Pyrimidine Metabolism, Inborn Errors; Radioisotope Dilution Technique | 1986 |
A method for assaying orotate phosphoribosyltransferase and measuring phosphoribosylpyrophosphate.
Topics: Animals; Cattle; Cells, Cultured; Cellulose; Methods; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Polyethyleneimine; Uridine Monophosphate | 1987 |
Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria.
Topics: Adenine Phosphoribosyltransferase; Animals; Carboxy-Lyases; Cattle; Disease Models, Animal; Erythrocytes; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase | 1987 |
Effect of uridine diphosphoglucose on levels of 5-phosphoribosyl pyrophosphate and uridine triphosphate in murine tissues.
Topics: Animals; Chromatography, High Pressure Liquid; Liver; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental; Orotic Acid; Pentosephosphates; Phosphoribosyl Pyrophosphate; Uridine Diphosphate Glucose; Uridine Diphosphate Sugars; Uridine Triphosphate | 1989 |
Phosphoribosylpyrophosphate bioavailability in diabetic rat renal cortex in vivo.
Topics: Adenine; Adenosine Triphosphate; Animals; Biological Availability; Diabetes Mellitus, Experimental; Infusions, Parenteral; Kidney Cortex; Male; Orotic Acid; Pentosephosphates; Phosphoribosyl Pyrophosphate; Rats; RNA; Uridine Triphosphate | 1980 |
Adenosine- and deoxyadenosine-mediated altered pyrimidine metabolism in human adeosine deaminase-deficient lymphoblasts.
Topics: Adenosine; Adenosine Deaminase; Cell Division; Cell Line; Deoxyadenosines; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Lymphocytes; Nucleoside Deaminases; Orotic Acid; Phosphoribosyl Pyrophosphate; Pyrimidines; Uridine | 1982 |
A new method for measuring urinary orotic acid.
Topics: Adolescent; Child; Child, Preschool; Creatinine; Humans; Infant; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosephosphates; Phosphoribosyl Pyrophosphate; Reference Values; Spectrophotometry | 1982 |
Effects of caffeine on pyrimidine biosynthesis and 5-phosphoribosyl 1-pyrophosphate metabolism in Chinese hamster cells.
Topics: Animals; Caffeine; Cell Line; Cricetinae; Cricetulus; Cytidine Triphosphate; Female; Kinetics; Orotate Phosphoribosyltransferase; Orotic Acid; Ovary; Pentosephosphates; Phosphoribosyl Pyrophosphate; Pyrimidines; Uridine Triphosphate | 1982 |
Rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by rat liver cytosolic enzymes.
Topics: Animals; Carboxy-Lyases; Cytosol; Dihydroorotate Oxidase; Liver; Male; Mitochondria, Liver; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Rats, Inbred Strains; Uracil Nucleotides; Uridine Monophosphate | 1983 |
Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma.
Topics: Adenocarcinoma; Allopurinol; Animals; Colonic Neoplasms; Female; Fluorouracil; Humans; Hypoxanthines; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Rectal Neoplasms; Ribosemonophosphates; Transplantation, Heterologous; Uridine Phosphorylase | 1983 |
Studies on the glycosomal orotate phosphoribosyl transferase of Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Hydrogen-Ion Concentration; Magnesium; Microbodies; Organoids; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Substrate Specificity; Trypanosoma cruzi | 1983 |
De novo synthesis of purine nucleotides in human blood platelets.
Topics: Adenine; Allopurinol; Azaserine; Blood Platelets; Formates; Humans; Hypoxanthines; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine Nucleotides | 1980 |
The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Topics: Binding Sites; Computer Graphics; Crystallization; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Conformation; Protein Structure, Tertiary; Salmonella typhimurium; Uridine Monophosphate | 1995 |
Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Chromatography, Ion Exchange; Conserved Sequence; Electrophoresis, Polyacrylamide Gel; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Conformation; Salmonella typhimurium; Sequence Homology, Amino Acid | 1995 |
The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase.
Topics: Cations, Divalent; Enzyme Activation; Magnesium; Manganese; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Salmonella typhimurium; Substrate Specificity; Uracil | 1993 |
Enzymatic production of pyrimidine nucleotides using Corynebacterium ammoniagenes cells and recombinant Escherichia coli cells: enzymatic production of CDP-choline from orotic acid and choline chloride (Part I).
Topics: Carbon-Nitrogen Ligases; Choline; Chromatography, High Pressure Liquid; Corynebacterium; Cytidine Diphosphate Choline; Cytidine Triphosphate; Escherichia coli; Gene Expression Regulation, Enzymologic; Ligases; Orotic Acid; Phosphoribosyl Pyrophosphate; Plasmids; Pyrimidine Nucleotides; Saccharomyces cerevisiae; Substrate Specificity; Uridine Diphosphate; Uridine Monophosphate; Uridine Triphosphate | 1997 |
Construction of a plasmid carrying both CTP synthetase and a fused gene formed from cholinephosphate cytidylyltransferase and choline kinase genes and its application to industrial CDP-choline production: enzymatic production of CDP-choline from orotic ac
Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Carbon-Nitrogen Ligases; Choline Kinase; Cloning, Molecular; Corynebacterium; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Escherichia coli; Fermentation; Gene Expression Regulation, Enzymologic; Ligases; Molecular Sequence Data; Orotic Acid; Phosphoribosyl Pyrophosphate; Plasmids; Saccharomyces cerevisiae | 1997 |
Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus.
Topics: Enzyme Stability; Hot Temperature; Kinetics; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Denaturation; Recombinant Proteins; Sequence Deletion; Temperature; Thermus thermophilus | 1999 |
FORMATION OF RIBOMONONUCLEOTIDES FROM PURINE AND PYRIMIDINE BASES AND 5'-PHOSPHORIBOSYLPYROPHOSPHATE BY A SALMON MILT EXTRACT.
Topics: Adenine; Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography; Cytosine; Cytosine Nucleotides; Diphosphates; Fishes; Guanine; Guanine Nucleotides; Metabolism; Nucleotides; Orotic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Research; Salmon; Thymine; Tissue Extracts; Tritium; Uracil; Uracil Nucleotides; Xanthines | 1964 |
Orotate phosphoribosyltransferase from Corynebacterium ammoniagenes lacking a conserved lysine.
Topics: Bacterial Proteins; Cations, Divalent; Chromatography, Gel; Cloning, Molecular; Coenzymes; Conserved Sequence; Corynebacterium; Dimerization; Diphosphates; Enzyme Stability; Escherichia coli; Gene Expression; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Molecular Weight; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Recombinant Proteins; Sequence Analysis, DNA; Uridine Monophosphate | 2007 |
Structure of Salmonella typhimurium OMP synthase in a complete substrate complex.
Topics: Catalytic Domain; Crystallography, X-Ray; Magnesium; Models, Molecular; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Binding; Protein Conformation; Protein Multimerization; Salmonella typhimurium | 2012 |