phosphoribosyl pyrophosphate has been researched along with methotrexate in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buesa, JM; Leyva, A; Pinedo, HM | 1 |
| Barankiewicz, J; Henderson, JF; Lowe, JK | 1 |
| Cadman, E; Davis, L; Heimer, R | 1 |
| Liliemark, J; Peterson, C; Pettersson, B | 1 |
| Bertino, JR; Colofiore, JR; Li, WW; Romanini, A | 1 |
| Coit, D; Colofiore, J; Kelsen, D; Martin, DS; Sawyer, R | 1 |
| Ishioka, C; Kakuta, H; Kanamaru, R; Sato, T; Wakui, A | 1 |
| Bakker, MA; Bökkerink, JP; de Abreu, RA; de Bruijn, CH; Hulscher, TW; Schretlen, ED; van Laarhoven, JP | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RR; De Bruyn, CH; Hulscher, TW; Schretlen, ED; van Laarhoven, JP | 1 |
| Ghitis, J; Schreiber, C; Waxman, S | 1 |
| Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RA; Hulscher, TW; Schretlen, ED | 1 |
| Colofiore, J; Derby, S; Kemeny, N; Martin, DS; Salvia, B; Sawyer, RC; Schneider, A | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 2 |
| Buesa, JM | 1 |
| Benz, C; Cadman, E | 1 |
| Benz, C; Cadman, E; Heimer, R | 1 |
| Lankelma, J; Leyva, A; Nederbragt, H; Pinedo, HM | 1 |
| Benz, C; Cadman, E; Tattelman, E; Tillis, T | 1 |
| Browman, GP | 1 |
| Ahmed, T; Harper, HD; Kemeny, NE; Michaelson, RA; Yip, LC | 1 |
| Buesa-Perez, JM; Leyva, A; Pinedo, HM | 1 |
| Elisseyeff, Y; Goker, E; Guarino, L; Kheradpour, A; Meyers, PA; Tan, CT; Tong, WP; Trippett, T; VanSyckle, KM; Wollner, N | 1 |
| Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Qiu, Y; Richards, DF; Rückemann, K; Simmonds, HA; Swaminathan, R | 1 |
4 trial(s) available for phosphoribosyl pyrophosphate and methotrexate
| Article | Year |
|---|---|
A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate | 1992 |
Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA; Drug Synergism; Fluorouracil; Humans; Immunosuppression Therapy; Mammary Neoplasms, Experimental; Methotrexate; Mice; Neoplasms; Phosphoribosyl Pyrophosphate; Rats; RNA; Sarcoma 180; Thymidylate Synthase | 1984 |
Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Lymphocytes; Male; Methotrexate; Middle Aged; Mucous Membrane; Nausea; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Prospective Studies; Rectal Neoplasms; Ribose-Phosphate Pyrophosphokinase; Thrombocytopenia; Vomiting | 1984 |
Pharmacologic-guided trial of sequential methotrexate and thioguanine in children with advanced malignancies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Leukemia; Lymphoma; Male; Methotrexate; Neoplasms; Phosphoribosyl Pyrophosphate; Remission Induction; Thioguanine | 1994 |
21 other study(ies) available for phosphoribosyl pyrophosphate and methotrexate
| Article | Year |
|---|---|
Increase of phosphoribosylpyrophosphate levels in cultured L1210 leukemia cells exposed to methotrexate.
Topics: Animals; Dose-Response Relationship, Drug; Hypoxanthines; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase | 1979 |
Purine and pyrimidine metabolism: pathways, pitfalls and perturbations.
Topics: Adenine Phosphoribosyltransferase; Animals; Lymphoma; Methotrexate; Mycophenolic Acid; Nucleotides; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Purines; Pyrimidine Nucleotides; Pyrimidines; Ribose-Phosphate Pyrophosphokinase | 1977 |
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
Topics: Animals; Cells, Cultured; Drug Administration Schedule; Drug Synergism; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Ribonucleotides; RNA, Neoplasm; Thymidylate Synthase | 1979 |
On the biochemical modulation of 6-mercaptopurine by methotrexate in murine WEHI-3b leukemia cells in vitro.
Topics: Animals; Drug Interactions; Extracellular Space; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Kinetics; Leukemia, Experimental; Leukemia, Myelomonocytic, Acute; Mercaptopurine; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Purines; Thionucleotides; Tumor Cells, Cultured; Xanthines | 1992 |
Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate; Phosphoribosyl Pyrophosphate; Trimetrexate; Tumor Cells, Cultured | 1992 |
The efficacy of combined therapy with methotrexate and 5-fluorouracil from the view point of cellular PRPP level of L1210 cells and HeLa S3 cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1985 |
Increased availability of phosphoribosyl pyrophosphate as the basis for enhanced 6-mercaptopurine incorporation by methotrexate, in cultured human lymphoblasts.
Topics: B-Lymphocytes; Cell Line; Humans; Mercaptopurine; Methotrexate; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purines; T-Lymphocytes | 1986 |
Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
Topics: Aminoimidazole Carboxamide; Cell Line; Drug Synergism; Glutamine; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; T-Lymphocytes | 1986 |
Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism.
Topics: Cell Line; Deoxyuridine; Erythrocytes; Folic Acid; Humans; Leucovorin; Leukemia, Myeloid, Acute; Male; Methotrexate; Pentosephosphates; Phosphates; Phosphoribosyl Pyrophosphate; Purines; Stimulation, Chemical | 1987 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages.
Topics: Aminoimidazole Carboxamide; Drug Synergism; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Lymphocytes; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; Tumor Cells, Cultured | 1988 |
Phase I trial of N-(phosphonacetyl)-L-aspartate, methotrexate, and 5-fluorouracil with leucovorin rescue in patients with advanced cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; Carcinoma, Squamous Cell; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1989 |
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1985 |
[Use of purine rescue pathways by L1210 cells exposed to methotrexate in vitro].
Topics: Animals; Chromatography, Liquid; Hypoxanthines; In Vitro Techniques; Leukemia L1210; Methotrexate; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides | 1982 |
Biochemical alterations during unperturbed suspension growth of L1210 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; DNA, Neoplasm; Floxuridine; Leukemia L1210; Methotrexate; Mice; Neoplasm Proteins; Phosphoribosyl Pyrophosphate; Ribonucleotides; RNA, Neoplasm | 1981 |
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Topics: Animals; Biological Transport; Deoxyuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Purines; RNA, Neoplasm | 1981 |
Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Head and Neck Neoplasms; Humans; Hypoxanthines; Inosine; Leukemia L1210; Methotrexate; Mice; Nucleosides; Phosphoribosyl Pyrophosphate; Thymidine | 1981 |
Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer.
Topics: Breast Neoplasms; Cell Line; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthines; Leucovorin; Leukopenia; Methotrexate; Nausea; Phosphoribosyl Pyrophosphate; Time Factors | 1982 |
Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines. Effects of drugs.
Topics: Animals; Aspartic Acid; Buffers; Cell Line; Cytological Techniques; Fibroblasts; Humans; Melanoma; Methotrexate; Mice; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Purine Nucleosides; Trypsin | 1984 |
Effect of methotrexate on 5-phosphoribosyl 1-pyrophosphate levels in L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Hypoxanthines; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase; Time Factors | 1980 |
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Topics: Amidophosphoribosyltransferase; Arthritis, Rheumatoid; Bicarbonates; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Nucleotides; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Protein Biosynthesis; Proteins; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine | 1999 |