phosphoribosyl pyrophosphate has been researched along with hypoxanthine in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (53.49) | 18.7374 |
| 1990's | 13 (30.23) | 18.2507 |
| 2000's | 7 (16.28) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chilson, OP | 1 |
| Liliemark, J; Peterson, C; Pettersson, B | 1 |
| Chen, TL; Erlichman, C | 1 |
| Berman, PA; Human, L | 1 |
| Black, D; Cole, P; Harley, E; Hickman, R; Marinaki, T | 1 |
| Bowditch, J; Brown, AK; Dow, JW; Raeside, DL | 1 |
| Barankiewicz, J; Cohen, A | 2 |
| Fairbanks, LD; Simmonds, HA; Webster, DR | 1 |
| Hers, HG; Van den Berghe, G; Vincent, MF | 3 |
| Gerber, G; Giacomello, A; Salerno, C | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RR; De Bruyn, CH; Hulscher, TW; Schretlen, ED; van Laarhoven, JP | 1 |
| Ghitis, J; Waxman, S | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RA; Hulscher, TW; Schretlen, ED | 1 |
| Camici, M; Cellini, F; Del Corso, A; Ipata, PL; Mura, U; Turchi, G | 1 |
| Choy, YM; Fung, KP; Lam, WP | 1 |
| Canellakis, ES; Vitkauskas, G | 2 |
| Godfrey, J; Plagemann, PG; Wohlhueter, RM | 1 |
| Buttin, G; Colella, CM; Debatisse, M; Simili, M | 1 |
| Achterberg, PW; de Jong, JW; de Tombe, PP; Harmsen, E | 1 |
| Avi-Dor, Y; Diamant, P; Ravid, K | 1 |
| Harley, EH; Steyn, LM | 1 |
| Fattal, A; Sperling, O; Spirer, Z; Zoref-Shani, E | 1 |
| Buttin, G; Debatisse, M; Fernandez-Mejia, C | 1 |
| Ahmed, N; Weidemann, MJ | 1 |
| Fukui, T; Hayashi, Y; Hirai, S; Ichikawa, A; Koizumi, T; Nakanishi, N | 1 |
| Boritzki, TJ; Cook, PD; Fry, DW; Jackson, RC; Leopold, WR | 1 |
| Eads, J; Grubmeyer, C; Sacchettini, JC; Xu, Y | 1 |
| Downs, SM | 1 |
| Cascante, M; Curto, R; Sorribas, A; Voit, EO | 1 |
| Furneaux, RH; Girvin, ME; Grubmeyer, C; Kicska, G; Li, CM; Schramm, VL; Tyler, PC; Xu, Y | 1 |
| Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Qiu, Y; Richards, DF; Rückemann, K; Simmonds, HA; Swaminathan, R | 1 |
| Bromberg, Y; Feinstein, S; Frishberg, Y; Sperling, O; Zoref-Shani, E | 1 |
| Balaram, H; Shivashankar, K; Sujay Subbayya, IN; Sukumaran, S | 1 |
| Balaram, H; Sujay Subbayya, IN | 1 |
| Craig, SP; Eakin, AE; Lee, CC; Medrano, FJ | 1 |
| Barsotti, C; Ipata, PL; Tozzi, MG | 1 |
| Balaram, H; Subbayya, IN | 1 |
| Bryant, RE; Crawford, CR | 1 |
| Craig, SP; Eakin, AE; Medrano, FJ; Wenck, MA | 1 |
43 other study(ies) available for phosphoribosyl pyrophosphate and hypoxanthine
| Article | Year |
|---|---|
Contrast in adenine uptake by chicken and rabbit erythrocytes in vitro.
Topics: Adenine; Adenine Nucleotides; Adenine Phosphoribosyltransferase; Animals; Blood Proteins; Cell Membrane Permeability; Chickens; Chromatography, Thin Layer; Erythrocytes; Guanine; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Phosphoribosyl Pyrophosphate; Rabbits; Temperature | 1992 |
On the biochemical modulation of 6-mercaptopurine by methotrexate in murine WEHI-3b leukemia cells in vitro.
Topics: Animals; Drug Interactions; Extracellular Space; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Kinetics; Leukemia, Experimental; Leukemia, Myelomonocytic, Acute; Mercaptopurine; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Purines; Thionucleotides; Tumor Cells, Cultured; Xanthines | 1992 |
Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Survival; Cytidine Triphosphate; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Drug Interactions; Fluorodeoxyuridylate; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Phosphoribosyl Pyrophosphate; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Triphosphate | 1992 |
Regulation of 5-phosphoribosyl 1-pyrophosphate and of hypoxanthine uptake and release in human erythrocytes by oxypurine cycling.
Topics: Biological Transport; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Kinetics; Models, Biological; Nucleotidases; Oxygen; Partial Pressure; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Purines; Xanthine Oxidase | 1990 |
Applications of PRPP metabolism in human erythrocytes.
Topics: Animals; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Ischemia; Kidney; Male; Perfusion; Phosphoribosyl Pyrophosphate; Rats; Reperfusion Injury | 1991 |
Metabolism and salvage of adenine and hypoxanthine by myocytes isolated from mature rat heart.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Enzymes; Guanosine Monophosphate; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine Monophosphate; Myocardium; Phosphoribosyl Pyrophosphate; Rats; Ribose | 1985 |
Purine nucleotide metabolism in resident and activated rat macrophages in vitro.
Topics: Adenine; Adenosine; Animals; Cells, Cultured; Guanine; Guanosine; Hypoxanthine; Hypoxanthines; Inosine; Macrophage Activation; Macrophages; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Rats; Thioglycolates | 1985 |
Usefulness of intact erythrocyte studies in the diagnosis of inherited purine and pyrimidine defects.
Topics: Adenine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocytes; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine-Pyrimidine Metabolism, Inborn Errors; Radioisotope Dilution Technique | 1986 |
Effect of fructose on the concentration of phosphoribosylpyrophosphate in isolated hepatocytes.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Fructose; Hexoses; Hypoxanthine; Hypoxanthines; Liver; Pentosephosphates; Phosphates; Phosphoribosyl Pyrophosphate; Rats; Xylitol | 1986 |
Regulatory aspects of hypoxanthine uptake by human erythrocytes.
Topics: Diphosphoglyceric Acids; Erythrocyte Membrane; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine Monophosphate; Oxygen; Pentosephosphates; Phosphates; Phosphoribosyl Pyrophosphate | 1986 |
Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
Topics: Aminoimidazole Carboxamide; Cell Line; Drug Synergism; Glutamine; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; T-Lymphocytes | 1986 |
Modified phosphoribosylpyrophosphate (PRPP) radioenzymatic assay: increased sensitivity, technical simplification and new applications.
Topics: Cell Line; Erythrocytes; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Pentosephosphates; Phosphoribosyl Pyrophosphate; Reference Standards | 1987 |
Purine nucleotide metabolism in phytohemagglutinin-induced human T lymphocytes.
Topics: Adenine; Adenine Nucleotides; DNA; Guanine; Guanine Nucleotides; Humans; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Purine Nucleotides; RNA; T-Lymphocytes | 1987 |
Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages.
Topics: Aminoimidazole Carboxamide; Drug Synergism; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Lymphocytes; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; Tumor Cells, Cultured | 1988 |
Alpha-5-phosphoribosyl-1-pyrophosphate-independent salvage of purines in cultured Chinese hamster lung fibroblasts.
Topics: Animals; Azaguanine; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Lung; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Purine-Nucleoside Phosphorylase; Ribosemonophosphates | 1988 |
Increase in phosphoribosyl pyrophosphate induced by ATP and Pi depletion in hepatocytes.
Topics: Adenosine Triphosphate; Animals; Cell Separation; Fructose; Hexoses; Hypoxanthine; Hypoxanthines; Liver; Pentosephosphates; Phosphates; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Xylitol; Xylulose | 1989 |
Interrelationship of number of glucose carriers and intracellular phosphoribosyl diphosphate level of Ehrlich ascites tumor cells in vitro.
Topics: 2,4-Dinitrophenol; Animals; Binding Sites; Biological Transport; Carcinoma, Ehrlich Tumor; Cytochalasin B; Dinitrophenols; Extracellular Space; Glucose; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1988 |
Quantitation of metabolic cooperation by measurement of HGPRTase activity.
Topics: Animals; Autoradiography; Cell Communication; Cell Line; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Methods; Mice; Phosphoribosyl Pyrophosphate | 1985 |
The biochemical determinants of hypoxanthine uptake in Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Cell Division; Cycloheximide; Dactinomycin; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetics; Liver Neoplasms, Experimental; Phosphoribosyl Pyrophosphate; Rats; Ribose-Phosphate Pyrophosphokinase | 1982 |
Increased inhibition of HGPRT by IMP and GMP and higher levels of PRPP in an 8-azaguanine - hat resistant mutant of Chinese hamster cells.
Topics: Animals; Azaguanine; Cell Line; Cricetinae; Culture Media; Guanine Nucleotides; Guanosine Monophosphate; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Inosine Nucleotides; Kinetics; Mutation; Pentosephosphates; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase | 1983 |
Enhanced ATP and GTP synthesis from hypoxanthine or inosine after myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Guanosine Triphosphate; Hypoxanthine; Hypoxanthines; Inosine; Male; Phosphoribosyl Pyrophosphate; Rats; Rats, Inbred Strains; Uric Acid; Xanthine; Xanthines | 1984 |
Regulation of the salvage pathway of purine nucleotide synthesis by the oxidation state of NAD+ in rat heart cells.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cells, Cultured; Glycolysis; Hypoxanthine; Hypoxanthines; Lactates; Lactic Acid; Methylphenazonium Methosulfate; Myocardium; NAD; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Substrate inhibition in a human variant of hypoxanthine-guanine phosphoribosyltransferase.
Topics: Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetics; Mathematics; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1984 |
Lesch-Nyhan syndrome: biochemical characterization of a case with attenuated behavioral manifestation.
Topics: Adult; Child, Preschool; Female; Fibroblasts; Heterozygote; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetics; Lesch-Nyhan Syndrome; Male; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1984 |
The regulation of hypoxanthine guanine phosphoribosyl transferase activity through transfer of PRPP by metabolic cooperation.
Topics: Adenine; Animals; Cell Communication; Cell Line; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate; Tubercidin | 1984 |
Adenosine-resistant Chinese hamster fibroblast variants with hyperactive adenosine-deaminase: an analysis of the protection against exogenous adenosine afforded by increased activity of the deamination pathway.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Line; Coformycin; Cricetinae; Cricetulus; Drug Resistance; Fibroblasts; Hypoxanthine; Hypoxanthines; Inosine; Models, Chemical; Nucleoside Deaminases; Phosphoribosyl Pyrophosphate; Purines | 1984 |
Metabolism of hypoxanthine in isolated rat hepatocytes.
Topics: Allopurinol; Animals; Ethanol; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; In Vitro Techniques; Kinetics; Liver; Male; Nucleotides; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Rats; Rats, Inbred Strains; Xanthine Oxidase | 1984 |
Biochemical effect of three different inhibitors of purine/pyrimidine metabolism on differentiation in HL60 cells.
Topics: Alanine; Cell Differentiation; Cell Division; Formates; Hematopoiesis; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine Monophosphate; Isoxazoles; Leukemia, Myeloid; Mycophenolic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Reactive Oxygen Species; Tumor Cells, Cultured | 1995 |
Fibroblast growth factor-dependent metabolism of hypoxanthine via the salvage pathway for purine synthesis in porcine aortic endothelial cells.
Topics: Animals; Aorta; Cell Division; Cells, Cultured; Endothelium, Vascular; Fibroblast Growth Factors; Hypoxanthine; Hypoxanthines; Nucleic Acids; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Ribose-Phosphate Pyrophosphokinase; Swine | 1993 |
Inhibition of 5-phosphoribosyl-1-pyrophosphate synthetase by the monophosphate metabolite of 4-amino-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine: a novel mechanism for antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; DNA; Humans; Hypoxanthine; Hypoxanthines; Mice; Pentostatin; Phosphoribosyl Pyrophosphate; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Ribose-Phosphate Pyrophosphokinase; RNA; Tumor Cells, Cultured; Uridine | 1993 |
Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry.
Topics: Guanine; Guanosine Monophosphate; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Models, Chemical; Models, Molecular; Phosphoribosyl Pyrophosphate; Protein Conformation; Recombinant Proteins | 1997 |
Hypoxanthine regulation of oocyte maturation in the mouse: insights using hypoxanthine phosphoribosyltransferase-deficient animals.
Topics: Animals; Biological Transport, Active; Bucladesine; Female; Follicle Stimulating Hormone; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Kinetics; Meiosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Oocytes; Phosphoribosyl Pyrophosphate | 1997 |
Validation and steady-state analysis of a power-law model of purine metabolism in man.
Topics: Adenine; Adenine Phosphoribosyltransferase; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Kinetics; Models, Biological; Phosphoribosyl Pyrophosphate; Purines; Sensitivity and Specificity; Uric Acid; Xanthine; Xanthines | 1997 |
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.
Topics: Animals; Binding Sites; Catalysis; Diphosphates; Drug Design; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Hydrogen Bonding; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Magnesium Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphoribosyl Pyrophosphate; Phosphorylation; Plasmodium falciparum; Protein Binding; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles | 1999 |
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Topics: Amidophosphoribosyltransferase; Arthritis, Rheumatoid; Bicarbonates; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Nucleotides; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Protein Biosynthesis; Proteins; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine | 1999 |
Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations.
Topics: Acute Kidney Injury; Adenine; Cells, Cultured; Child, Preschool; Culture Media, Conditioned; DNA Mutational Analysis; Fibroblasts; Gout; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Jews; Lymphocytes; Male; Nucleic Acids; Nucleotides; Phosphoribosyl Pyrophosphate; Purines; Syndrome; Uric Acid | 2000 |
Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Escherichia coli; Guanine; Guanosine Monophosphate; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Kinetics; Molecular Sequence Data; Molecular Weight; Phosphoribosyl Pyrophosphate; Plasmodium falciparum; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Xanthine | 2000 |
Evidence for multiple active states of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Guanine; Hypoxanthine; Kinetics; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Plasmodium falciparum; Recombinant Proteins | 2000 |
Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase.
Topics: Animals; Binding Sites; Catalysis; Diphosphates; Gene Deletion; Guanine; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Models, Molecular; Mutation; Phosphoribosyl Pyrophosphate; Trypanosoma cruzi | 2001 |
Purine and pyrimidine salvage in whole rat brain. Utilization of ATP-derived ribose-1-phosphate and 5-phosphoribosyl-1-pyrophosphate generated in experiments with dialyzed cell-free extracts.
Topics: Adenine; Adenosine Triphosphate; Animals; Brain; Cell-Free System; Cytosine; Dose-Response Relationship, Drug; Hypoxanthine; Ischemia; Models, Chemical; Pentoses; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Rats; Reperfusion Injury; Ribosemonophosphates; Time Factors | 2002 |
A point mutation at the subunit interface of hypoxanthine-guanine-xanthine phosphoribosyltransferase impairs activity: role of oligomerization in catalysis.
Topics: Animals; Catalysis; Guanine; Hypoxanthine; Models, Molecular; Mutagenesis, Site-Directed; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Plasmodium falciparum; Protein Structure, Tertiary; Structure-Activity Relationship; Xanthine | 2002 |
Isolation of a Chinese hamster cell mutant with low intracellular phosphoribosylpyrophosphate concentration.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Cricetinae; Cricetulus; Guanine; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase; Tritium | 1982 |
Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Topics: Animals; Diphosphates; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Kinetics; Molecular Structure; Phosphoribosyl Pyrophosphate; Trypanosoma cruzi; Trypsin | 2004 |