phosphoribosyl pyrophosphate and aspartic acid

phosphoribosyl pyrophosphate has been researched along with aspartic acid in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (45.45)	18.7374
1990's	5 (45.45)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Elliott, H; Madsen, G; McCairns, E; Rowe, PB; Sauer, D	1
Colofiore, JR; Koutcher, JA; Martin, DS; Nord, LD; Stolfi, RL	1
Coit, D; Colofiore, J; Kelsen, D; Martin, DS; Sawyer, R	1
Colofiore, J; Comis, RL; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF; Walczak, J	1
Colofiore, J; Derby, S; Kemeny, N; Martin, DS; Salvia, B; Sawyer, RC; Schneider, A	1
Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM	2
Barratt, E; Boorman, KN; Buttery, PJ	1
Dorfman, RH; Grubmeyer, C; Ozturk, DH; Sacchettini, JC; Scapin, G	1
Hove-Jensen, B; Nilsson, D; Willemoës, M	1
Bello, Z; Grubmeyer, C; Stitt, B	1

Trials

2 trial(s) available for phosphoribosyl pyrophosphate and aspartic acid

Article	Year
A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site. Cancer, 1992, Oct-01, Volume: 70, Issue:7 Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate	1992
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine riboside: optimization of 6-methylmercaptopurine riboside dose and schedule through biochemical analysis of sequential tumor biopsy specimens. Journal of the National Cancer Institute, 1991, Sep-04, Volume: 83, Issue:17 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1991

Article

Year

A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site.

Cancer, 1992, Oct-01, Volume: 70, Issue:7

Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate

1992

Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine riboside: optimization of 6-methylmercaptopurine riboside dose and schedule through biochemical analysis of sequential tumor biopsy specimens.

Journal of the National Cancer Institute, 1991, Sep-04, Volume: 83, Issue:17

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate

1991

Other Studies

9 other study(ies) available for phosphoribosyl pyrophosphate and aspartic acid

Article	Year
De novo purine synthesis in avian liver. Co-purification of the enzymes and properties of the pathway. The Journal of biological chemistry, 1978, Nov-10, Volume: 253, Issue:21 Topics: Amidophosphoribosyltransferase; Animals; Aspartic Acid; Bicarbonates; Carboxy-Lyases; Chromatography, High Pressure Liquid; Columbidae; Glycine; Imidazoles; Kinetics; Liver; Peptide Synthases; Phosphoribosyl Pyrophosphate; Potassium; Purines; Ribonucleotides; Ribosemonophosphates	1978
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination. Cancer research, 1992, Aug-01, Volume: 52, Issue:15 Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Orotic Acid; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1992
Phase I trial of N-(phosphonacetyl)-L-aspartate, methotrexate, and 5-fluorouracil with leucovorin rescue in patients with advanced cancer. Cancer research, 1989, Aug-15, Volume: 49, Issue:16 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; Carcinoma, Squamous Cell; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1989
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites. The International journal of biochemistry, 1985, Volume: 17, Issue:1 Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate	1985
Urate synthesis in the perfused chick liver. The Biochemical journal, 1974, Volume: 144, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonium Chloride; Animals; Aspartic Acid; Carbon Radioisotopes; Chickens; Glutamine; Glycine; Inosine; Inosine Monophosphate; Insulin; Liver; Oxygen Consumption; Perfusion; Phosphoribosyl Pyrophosphate; Ribonucleosides; Tritium; Uric Acid; Xanthines	1974
Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines. Effects of drugs. FEBS letters, 1984, May-21, Volume: 170, Issue:2 Topics: Animals; Aspartic Acid; Buffers; Cell Line; Cytological Techniques; Fibroblasts; Humans; Melanoma; Methotrexate; Mice; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Purine Nucleosides; Trypsin	1984
Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites. Biochemistry, 1995, Aug-29, Volume: 34, Issue:34 Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Chromatography, Ion Exchange; Conserved Sequence; Electrophoresis, Polyacrylamide Gel; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Conformation; Salmonella typhimurium; Sequence Homology, Amino Acid	1995
Effects of mutagenesis of aspartic acid residues in the putative phosphoribosyl diphosphate binding site of Escherichia coli phosphoribosyl diphosphate synthetase on metal ion specificity and ribose 5-phosphate binding. Biochemistry, 1996, Jun-25, Volume: 35, Issue:25 Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Cations, Divalent; Escherichia coli; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase; Ribosemonophosphates	1996
Interactions at the 2 and 5 positions of 5-phosphoribosyl pyrophosphate are essential in Salmonella typhimurium quinolinate phosphoribosyltransferase. Biochemistry, 2010, Feb-23, Volume: 49, Issue:7 Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Catalytic Domain; Enzyme Stability; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Protein Binding; Salmonella typhimurium; Substrate Specificity	2010