phosphoramidon has been researched along with phelorphan* in 1 studies
1 other study(ies) available for phosphoramidon and phelorphan
| Article | Year |
|---|---|
Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome.
Enkephalinase inhibitors phosphoramidon, thiorphan or phelorphan suppressed naloxone-precipitated withdrawal symptoms in acute and chronic morphine dependent mice and rats. It is suggested that decreased biotransformation of the endogenous opioid peptides might compensate the relative shortage of exogenous opiates during withdrawal in opiate dependent subjects and could be a new and promising way to attenuate the severity of abstinential syndrome. Topics: Amino Acids, Sulfur; Animals; Cerebral Ventricles; Cerebrospinal Fluid; Dipeptides; Glycopeptides; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1986 |