phosphoramidite has been researched along with triphosphoric-acid* in 3 studies
3 other study(ies) available for phosphoramidite and triphosphoric-acid
| Article | Year |
|---|---|
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition.
Two alternative flexible alkyne-linked thymine nucleosides (propargyl-diethylene glycol- or undecyn-linked 5-hydroxymethyluracil derivatives), as well as their phosphoramidites and triphosphates, were designed and synthesized. The nucleoside 3'- O-phosphoramidites were successfully incorporated into oligonucleotides on a solid support, whereas the nucleoside triphosphates served as good substrates for polymerase synthesis of modified DNA, which underwent fast and efficient copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reactions. Topics: Alkynes; Azides; Catalysis; Copper; Cycloaddition Reaction; DNA; Molecular Structure; Organophosphorus Compounds; Polyphosphates; Thymidine | 2018 |
Synthesis of novel nucleoside 5'-triphosphates and phosphoramidites containing alkyne or amino groups for the postsynthetic functionalization of nucleic acids.
A series of novel nucleoside 5'-triphosphates and phosphoramidites containing alkyne or amino groups for the postsynthetic functionalization of nucleic acids were designed and synthesized. For this purpose, the new 3-aminopropoxypropynyl linker group was used. It contains two alternative functional capabilities: an amino group for the reaction of amino-alkynyl-modified oligonucleotides with corresponding activated esters and an alkyne group for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. It was shown that a variety of methods of the attachment of the new linker can be used to synthesize a diversity of modified pyrimidine nucleosides. Topics: Alkynes; Azides; Copper; Cyclization; DNA; Nucleic Acids; Nucleosides; Nucleotides; Oligonucleotides; Organophosphorus Compounds; Polyphosphates | 2011 |
C-5 modified nucleosides: direct insertion of alkynyl-thio functionality in pyrimidines.
A route is presented to append, in a single step, alkynyl thioesters to the 5-position of a pyrimidine ring of a nucleoside that is unprotected. These products should be useful to support in vitro selection experiments with functionalized DNA. Topics: Alkynes; Chemistry, Organic; Organophosphorus Compounds; Palladium; Polyphosphates; Pyrimidine Nucleosides; Sulfhydryl Compounds | 2003 |