phosphoramidite and phosphorodithioic-acid

phosphoramidite has been researched along with phosphorodithioic-acid* in 1 studies

Other Studies

1 other study(ies) available for phosphoramidite and phosphorodithioic-acid

ArticleYear
Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites.
    The Journal of organic chemistry, 2012, Nov-02, Volume: 77, Issue:21

    This work describes a general method for the synthesis of oligoribonucleotides containing a site-specific nonbridging phosphorodithioate linkage via automated solid-phase synthesis using 5'-O-DMTr-2'-O-TBS-ribonucleoside 3'-N,N-dimethyl-S-(2,4-dichlorobenzyl) phosphorothioamidites (2a-2d). The 3'-phosphorothioamidites (2a-2d) can be conveniently prepared in good yields (86-99%) via a one-pot reaction from the corresponding 5'-O-DMTr-2'-O-TBS-ribonucleosides (1a-1d).

    Topics: Base Sequence; Molecular Structure; Oligonucleotides; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphates; Ribonucleosides; RNA; Solid-Phase Synthesis Techniques

2012