phosphoramidite has been researched along with 2-5-dimethylfuran* in 1 studies
1 other study(ies) available for phosphoramidite and 2-5-dimethylfuran
Article | Year |
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Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes.
[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate. Topics: Furans; Maleimides; Oligonucleotides; Organophosphorus Compounds; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds | 2012 |