Page last updated: 2024-08-26

phosphoramide mustard and acrolein

phosphoramide mustard has been researched along with acrolein in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199011 (61.11)18.7374
1990's3 (16.67)18.2507
2000's2 (11.11)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crowther, D; Dougal, M; Elder, RH; Lee, SM; Margison, GP; Rafferty, JA; Scarffe, JH1
Erexson, GL; Kligerman, AD; Wilmer, JL2
Hales, BF2
Kohn, FR; Sladek, NE1
Kawabata, TT; White, KL1
Crook, TR; McLean, AE; Souhami, RL1
Crook, TR; McLean, AE; Souhami, RL; Whyman, GD1
Hemminki, K; Kallama, S1
Hales, BF; Slott, VL1
Brendel, M; Fleer, R1
Jacob-Müller, U; Spielmann, H1
Chang, TK; Waxman, DJ1
Gamcsik, MP; Ludeman, SM1
Desmeules, P; Devine, PJ1
Alarcon, RA1
Escoli, R; Moroni, G; Ponticelli, C1

Reviews

3 review(s) available for phosphoramide mustard and acrolein

ArticleYear
Mechanisms of resistance against cyclophosphamide and ifosfamide: can they be overcome without sacrificing selectivity?
    Cancer treatment and research, 2002, Volume: 112

    Topics: Acrolein; Aldehyde Dehydrogenase; Antineoplastic Agents, Alkylating; Cyclophosphamide; DNA Repair; Drug Resistance, Neoplasm; Humans; Ifosfamide; Models, Chemical; O(6)-Methylguanine-DNA Methyltransferase; Phosphoramide Mustards; Stereoisomerism

2002
Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions.
    Medical hypotheses, 2012, Volume: 79, Issue:4

    Topics: Acrolein; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Humans; Hydroxyl Radical; Models, Biological; Neoplasms; Oxidation-Reduction; Oxidative Stress; Phosphoramide Mustards; Spermine

2012
Does cyclophosphamide still play a role in glomerular diseases?
    Autoimmunity reviews, 2018, Volume: 17, Issue:10

    Topics: Acrolein; Antineoplastic Agents; Cyclophosphamide; Cytochrome P-450 Enzyme System; Humans; Kidney Diseases; Phosphoramide Mustards

2018

Other Studies

15 other study(ies) available for phosphoramide mustard and acrolein

ArticleYear
Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation.
    British journal of cancer, 1992, Volume: 66, Issue:2

    Topics: Acrolein; Adenosine Triphosphatases; Adolescent; Adult; Bone Marrow Transplantation; Carmustine; Cyclophosphamide; Female; Humans; Kinetics; Leukemia; Lymphocytes; Lymphoma, Non-Hodgkin; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Phosphoramide Mustards; Recombinant Proteins; Transplantation, Autologous

1992
Effect of acrolein on phosphoramide mustard-induced sister chromatid exchanges in cultured human lymphocytes.
    Cancer research, 1990, Aug-01, Volume: 50, Issue:15

    Topics: Acrolein; Aldehydes; Cell Cycle; Cells, Cultured; Cyclophosphamide; Humans; Lymphocyte Activation; Phosphoramide Mustards; Sister Chromatid Exchange; T-Lymphocytes

1990
Effects of phosphoramide mustard and acrolein, cytotoxic metabolites of cyclophosphamide, on mouse limb development in vitro.
    Teratology, 1989, Volume: 40, Issue:1

    Topics: Acrolein; Aldehydes; Alkaline Phosphatase; Animals; Culture Techniques; Cyclophosphamide; Foot; Mice; Mice, Inbred ICR; Phosphocreatine; Phosphoramide Mustards; Proteins

1989
Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines.
    Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19

    Topics: Acrolein; Aldehyde Dehydrogenase; Animals; Bone Marrow Cells; Cisplatin; Colony-Forming Units Assay; Cyanamide; Cyclophosphamide; Disulfiram; Ditiocarb; Drug Synergism; Granulocytes; Hematopoietic Stem Cells; Male; Melphalan; Mice; Mice, Inbred BALB C; Nitrogen Mustard Compounds; Organophosphorus Compounds; Phosphinic Acids; Phosphoramide Mustards

1985
Attenuation of cytogenetic damage by 2-mercaptoethanesulfonate in cultured human lymphocytes exposed to cyclophosphamide and its reactive metabolites.
    Cancer research, 1986, Volume: 46, Issue:1

    Topics: Acrolein; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Mercaptoethanol; Mesna; Mitotic Index; Mutagenicity Tests; Phosphoramide Mustards; Sister Chromatid Exchange; T-Lymphocytes

1986
Enhancement of in vivo and in vitro murine immune responses by the cyclophosphamide metabolite acrolein.
    Cancer research, 1988, Jan-01, Volume: 48, Issue:1

    Topics: Acrolein; Aldehydes; Animals; Antibody-Producing Cells; Cell Survival; Cyclophosphamide; Female; Hypersensitivity, Delayed; Immunity; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phosphoramide Mustards; Sulfhydryl Compounds; T-Lymphocytes

1988
Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Acrolein; Aldehydes; Alkylation; Animals; Biotransformation; Cell Line; Cell Survival; Cyclophosphamide; DNA; DNA Damage; Humans; In Vitro Techniques; Leukemia, Myeloid; Liver; Male; Phosphoramide Mustards; Rats; Rats, Inbred Strains

1986
Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Acrolein; Aldehyde Dehydrogenase; Biotransformation; Buthionine Sulfoximine; Cell Line; Cell Survival; Cyclophosphamide; DNA Damage; Glutathione; Humans; Leukemia, Myeloid; Liver; Methionine Sulfoximine; Phosphoramide Mustards

1986
Reactions of nitrogen mustards with DNA.
    IARC scientific publications, 1986, Issue:78

    Topics: Acrolein; Alkylating Agents; Aziridines; Chemical Phenomena; Chemistry; Cross-Linking Reagents; Cyclophosphamide; DNA; DNA Damage; Magnetic Resonance Spectroscopy; Nitrogen Mustard Compounds; Phosphoramide Mustards

1986
Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro.
    Biochemical pharmacology, 1987, Jun-15, Volume: 36, Issue:12

    Topics: Abnormalities, Drug-Induced; Acrolein; Aldehydes; Animals; Buthionine Sulfoximine; Drug Synergism; Embryo, Mammalian; Female; Fetal Death; Glutathione; Methionine Sulfoximine; Phosphoramide Mustards; Pregnancy; Rats; Rats, Inbred Strains

1987
Toxicity, interstrand cross-links and DNA fragmentation induced by 'activated' cyclophosphamide in yeast: comparative studies on 4-hydroperoxy-cyclophosphamide, its monofunctional analogon, acrolein, phosphoramide mustard, and nor-nitrogen mustard.
    Chemico-biological interactions, 1982, Mar-01, Volume: 39, Issue:1

    Topics: Acrolein; Alkylating Agents; Biotransformation; Cross-Linking Reagents; Cyclophosphamide; DNA; Nitrogen Mustard Compounds; Phosphoramide Mustards; Saccharomyces cerevisiae; Time Factors

1982
Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein.
    Cancer research, 1982, Volume: 42, Issue:8

    Topics: Acrolein; Aldehydes; Animals; Cyclophosphamide; Drug Evaluation, Preclinical; Embryo, Mammalian; Female; Mutagenicity Tests; Mutagens; Mutation; Phosphoramide Mustards; Pregnancy; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Teratogens

1982
Investigation on cyclophosphamide treatment during the preimplantation period. II. In vitro studies on the effects of cyclophosphamide and its metabolites 4-OH-cyclophosphamide, phosphoramide mustard, and acrolein on blastulation of four-cell and eight-ce
    Teratology, 1981, Volume: 23, Issue:1

    Topics: Acrolein; Aldehydes; Animals; Blastocyst; Cyclophosphamide; Dose-Response Relationship, Drug; Embryonic Development; Female; Mice; Phosphoramide Mustards; Pregnancy; Teratogens

1981
Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.
    Cancer research, 1993, Jun-01, Volume: 53, Issue:11

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Acrolein; Animals; Aryl Hydrocarbon Hydroxylases; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Combinations; Ifosfamide; Male; Phosphoramide Mustards; Rats; Rats, Inbred F344; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone

1993
Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: Acrolein; Animals; Cyclophosphamide; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Ovarian Follicle; Phosphoramide Mustards

2006