phosphonoacetic acid has been researched along with uridine in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (71.43) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Handschumacher, RE; Moyer, JD | 1 |
| Johnson, RK | 1 |
| Edmunds, NH; Kwong, LK; Tsuboi, KK | 1 |
| Chan, TC; Kuczek, T | 1 |
| Martin, DS | 1 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Herrmann, G; Reefschläger, J; Thiel, KD; Wutzler, P | 2 |
| Chisena, CA; Cowan, KH; Cysyk, RL; Karle, JM | 1 |
| Cassady, JM; Jacobsen, LB; Morré, DJ; Putnam, JE; Sawick, DP | 1 |
| Chan, TC; Cleary, S; Howell, SB; Markman, M | 2 |
| Chan, TC; Howell, SB; King, ME; Taetle, R; Young, B | 1 |
| Chan, TC; Howell, SB | 1 |
| Seaver, SS; Stark, GR; Swyryd, EA | 1 |
| Cadman, E; Grant, S; Jakubowski, A; Rauscher, F | 1 |
| Anukarahanonta, T; Holstege, A; Keppler, DO | 1 |
| Anderson, LW; Cysyk, RL; Dietrick, DD; Karle, JM | 1 |
| Briggle, TV; Greer, S; Mekras, JA; Perez, LM | 1 |
| Hsiung, GD; Mayo, DR | 1 |
| de Saint Vincent, BR; Delbrück, S; Eckhart, W; Meinkoth, J; Vitto, L; Wahl, G | 1 |
| Anderson, LW; Cysyk, RL; Karle, JM | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG | 1 |
| Handschumacher, RE; Moyer, JD; Oliver, JT | 1 |
| Brinster, RL; Troike, DE | 1 |
| Anderson, LW; Cysyk, RL; Erlichman, C; Karle, JM | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Blough, HA; Grem, JL; Katsafanas, GC; Moss, B | 1 |
| Davidson, JN; Qiu, Y | 1 |
| Garcia, RA; Gonzalez, A; Hu, Z; Liu, L; Saydoff, JA; von Borstel, RW | 1 |
| Kemeny, NE; Leonard, GD | 1 |
1 review(s) available for phosphonoacetic acid and uridine
| Article | Year |
|---|---|
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
34 other study(ies) available for phosphonoacetic acid and uridine
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Female; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Organophosphorus Compounds; Orotic Acid; Phosphonoacetic Acid; Pyrazoles; Pyrimidine Nucleotides; Pyrimidines; Ribonucleosides; Uridine | 1979 |
Reversal of toxicity and antitumor activity of N-(phosphonacetyl)-L-aspartate by uridine or carbamyl-DL-asparate in vivo.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Body Weight; Carbamates; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1977 |
Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.
Topics: Animals; Aspartic Acid; Cell Division; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Humans; Kinetics; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidines; Transplantation, Isogeneic; Uridine | 1977 |
Mechanism-based model for tumor drug resistance.
Topics: Animals; Aspartic Acid; Cell Cycle; Cell Survival; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance; Models, Biological; Models, Statistical; Phosphonoacetic Acid; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Introduction to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
Efficacy of 5-vinyl-1-beta-D-arabinofuranosyluracil (VaraU) against herpes simplex virus type 2 strains in cell cultures and against experimental herpes encephalitis in mice: comparison with acyclovir and foscarnet.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Encephalitis; Female; Foscarnet; Herpes Simplex; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Simplexvirus; Uridine; Virus Replication | 1987 |
Uracil nucleotide synthesis in a human breast cancer cell line (MCF-7) and in two drug-resistant sublines that contain increased levels of enzymes of the de novo pyrimidine pathway.
Topics: Amides; Aspartate Carbamoyltransferase; Aspartic Acid; Breast Neoplasms; Carbamoyl-Phosphate Synthase (Ammonia); Cell Line; Dihydroorotase; Drug Resistance; Female; Humans; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Phosphonoacetic Acid; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Uracil Nucleotides; Uridine | 1986 |
Treatment of experimental herpes simplex virus type 1 encephalitis in mice with (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil: comparison with bromovinyl-deoxyuridine and acyclovir.
Topics: Acyclovir; Animals; Arabinofuranosyluracil; Bromodeoxyuridine; Cells, Cultured; Encephalitis; Female; Foscarnet; Herpes Simplex; Humans; Mice; Phosphonoacetic Acid; Simplexvirus; Uridine; Viral Plaque Assay | 1986 |
Pyrimidine nucleosides enhance the efficacy of inhibitors of pyrimidine biosynthesis in cultured hepatocellular carcinoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Cell Division; Cytidine; Liver Neoplasms, Experimental; Organophosphorus Compounds; Orotic Acid; Phosphonoacetic Acid; Pyrimidine Nucleosides; Pyrimidines; Rats; Tumor Cells, Cultured; Uridine | 1988 |
Plasma uridine changes in cancer patients treated with the combination of dipyridamole and N-phosphonacetyl-L-aspartate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyridamole; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1986 |
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyridamole; Drug Evaluation; Drug Synergism; Female; Gastrointestinal Diseases; Headache; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1987 |
Modulation of the activity of PALA by dipyridamole.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Line; Colonic Neoplasms; Dipyridamole; Drug Interactions; Humans; In Vitro Techniques; Lethal Dose 50; Leukemia, Myeloid; Melanoma; Mice; Mice, Nude; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidine Nucleosides; Tritium; Uridine | 1985 |
Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Line; Dipyridamole; Drug Synergism; Female; Humans; Nucleotides; Organophosphorus Compounds; Ovarian Neoplasms; Phosphonoacetic Acid; Uridine | 1985 |
N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Bicarbonates; Carbamates; Carbon Radioisotopes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Ion Exchange; Fibroblasts; Haplorhini; Kidney; Kinetics; Mice; Mice, Inbred Strains; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Simian virus 40; Species Specificity; Time Factors; Tritium; Uridine | 1974 |
Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Azacitidine; Cell Division; Cytidine; DNA, Neoplasm; Leukemia L1210; Leukemia, Experimental; Mice; Neoplasm Proteins; Organophosphorus Compounds; Phosphonoacetic Acid; RNA, Neoplasm; Uridine | 1981 |
Selective enhancement of 5-fluorouridine uptake and action in rat hepatomas in vivo following pretreatment with D-galactosamine and 6-azauridine or N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Azauridine; DNA, Neoplasm; Drug Therapy, Combination; Female; Galactosamine; Liver; Liver Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Rats; RNA, Neoplasm; Stimulation, Chemical; Uracil Nucleotides; Uridine | 1980 |
Effect of inhibitors of the de novo pyrimidine biosynthetic pathway on serum uridine levels in mice.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Azauridine; Galactosamine; Liver; Male; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Uridine | 1981 |
Marked radiosensitization of cells in culture to X ray by 5-chlorodeoxycytidine coadministered with tetrahydrouridine, and inhibitors of pyrimidine biosynthesis.
Topics: Animals; Aspartic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Radiation; Floxuridine; Humans; Laryngeal Neoplasms; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Tetrahydrouridine; Uridine | 1984 |
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Female; Foscarnet; Guinea Pigs; Herpes Genitalis; Injections, Intraperitoneal; Male; Phosphonoacetic Acid; Uridine; Virus Replication | 1984 |
The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Cloning, Molecular; Cricetinae; Cricetulus; Dihydroorotase; DNA, Recombinant; Drug Resistance; Female; Gene Amplification; Genes, Dominant; Genetic Markers; Genetic Vectors; Multienzyme Complexes; Ovary; Phosphonoacetic Acid; Proteins; Transformation, Genetic; Uridine | 1981 |
Effect of plasma concentrations of uridine on pyrimidine biosynthesis in cultured L1210 cells.
Topics: Animals; Aspartic Acid; Bicarbonates; Culture Media; Leukemia L1210; Mice; Phosphonoacetic Acid; Pyrimidines; Sodium Bicarbonate; Uracil Nucleotides; Uridine | 1984 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models, Animal; Epilepsy; Female; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Rats; Rats, Inbred Strains; Seizures; Uridine | 1982 |
Salvage of circulating pyrimidine nucleosides in the rat.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cytidine; Male; Phosphonoacetic Acid; Pyrazoles; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Rats; Ribonucleosides; Ribose; Tissue Distribution; Uridine | 1981 |
De novo pyrimidine nucleotide synthesis in the preimplantation mouse embryo.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Blastocyst; Mice; Morula; Orotic Acid; Phosphonoacetic Acid; Pyrimidine Nucleotides; Uridine | 1981 |
Serum uridine levels in patients receiving N-(phosphonacetyl)-L-aspartate.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Humans; Melanoma; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1980 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Inhibition of vaccinia virus replication by N-(phosphonoacetyl)-L-aspartate: differential effects on viral gene expression result from a reduced pyrimidine nucleotide pool.
Topics: Antiviral Agents; Aspartic Acid; Cell Survival; Cytidine Triphosphate; DNA-Directed RNA Polymerases; Gene Expression Regulation, Viral; HeLa Cells; Humans; Kinetics; Macromolecular Substances; Phosphonoacetic Acid; Pyrimidine Nucleotides; RNA, Messenger; Transcription, Genetic; Uridine; Uridine Triphosphate; Vaccinia virus; Virus Replication | 1997 |
CAD overexpression in mammalian cells.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Division; Cell Line; Cloning, Molecular; Cricetinae; Dihydroorotase; Molecular Sequence Data; Multienzyme Complexes; Phosphonoacetic Acid; Recombinant Proteins; Transfection; Uridine | 1998 |
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine.
Topics: Acetates; Animals; Apoptosis; Aspartic Acid; Azides; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex IV; Enzyme Inhibitors; Fibroblasts; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Phosphonoacetic Acid; Prodrugs; Pyrimidines; Uridine | 2005 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |