phosphonoacetic acid has been researched along with uridine triphosphate in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coit, D; Colofiore, J; Kelsen, D; Martin, DS; Sawyer, R | 1 |
| Kemeny, NE; Martin, DS | 1 |
| Corder, TS; Wild, JR | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Gerok, W; Holstege, A; Manglitz, D | 1 |
| Friedman, J; Loo, TL; Marti, JR; Moore, EC; Plunkett, W; Russ, J; Valdivieso, M | 1 |
| Ardalan, B; Cooney, DA; Glazer, RI; Jayaram, HN; Kensler, TW; Macdonald, JS; Van Pham, T | 1 |
| Durrani, FA; Rustum, YM; van Laar, JA | 1 |
| Kasperrs, GJ; Kazemier, KM; Noordhuis, P; Peters, GJ | 1 |
| Blough, HA; Grem, JL; Katsafanas, GC; Moss, B | 1 |
| Capizzi, RL; Case, L; Fernandes, DJ; Fleming, RA; Homesley, H; Loggie, BW; Morris, R; Muss, HB; Richards, F; Russell, GB; Smith, S | 1 |
| Evans, D; Guy, H; Hervé, G; Lux, M; Penverne, B; Rotgeri, A; Serre, V | 1 |
| Collins, M; Graves, LM; Haystead, TA; Huang, M; Kozlowski, P; Wang, Y | 1 |
| Cunin, R; Maes, D; Van Boxstael, S | 1 |
1 review(s) available for phosphonoacetic acid and uridine triphosphate
| Article | Year |
|---|---|
Modulation of fluorouracil by N-(phosphonacetyl)-L-asparate: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Phosphonoacetic Acid; RNA, Neoplasm; Thymidylate Synthase; Uridine Triphosphate | 1992 |
2 trial(s) available for phosphonoacetic acid and uridine triphosphate
| Article | Year |
|---|---|
A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate | 1992 |
Phase I study of N-(phosphonacetyl)-L-aspartate with fluorouracil and with or without dipyridamole in patients with advanced cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Dipyridamole; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leukocytes; Male; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine Triphosphate | 1996 |
11 other study(ies) available for phosphonoacetic acid and uridine triphosphate
| Article | Year |
|---|---|
Discrimination between nucleotide effector responses of aspartate transcarbamoylase due to a single site substitution in the allosteric binding site.
Topics: Adenosine Triphosphate; Allosteric Regulation; Aspartate Carbamoyltransferase; Aspartic Acid; Cytidine Triphosphate; DNA Mutational Analysis; Enzyme Activation; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Phosphonoacetic Acid; Structure-Activity Relationship; Uridine Triphosphate | 1989 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
Depletion of blood plasma cytidine due to increased hepatocellular salvage in D-galactosamine-treated rats.
Topics: Animals; Antimetabolites; Aspartic Acid; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cytidine; Female; Galactosamine; Liver; Nucleosides; Nucleotides; Phosphonoacetic Acid; Rats; Rats, Inbred Strains; Solubility; Uracil Nucleotides; Uridine Triphosphate | 1984 |
Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate.
Topics: Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Drug Evaluation; Humans; Kinetics; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Proteins; Pyrimidine Nucleotides; Uridine Triphosphate | 1982 |
Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma.
Topics: Antineoplastic Agents; Aspartic Acid; Breast Neoplasms; Cell Division; Cell Line; Drug Synergism; Female; Fluorouracil; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Poly A; RNA, Neoplasm; Uridine Triphosphate | 1981 |
Antitumor activity of the weekly intravenous push schedule of 5-fluoro-2'-deoxyuridine +/- N-phosphonacetyl-L-aspartate in mice bearing advanced colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Cytidine Triphosphate; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Infusions, Intravenous; Leukemia L1210; Mice; Mice, Inbred BALB C; Phosphonoacetic Acid; Uridine Triphosphate | 1993 |
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cytarabine; Cytidine Triphosphate; DNA, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Phosphonoacetic Acid; Tumor Cells, Cultured; Uridine Triphosphate | 1996 |
Inhibition of vaccinia virus replication by N-(phosphonoacetyl)-L-aspartate: differential effects on viral gene expression result from a reduced pyrimidine nucleotide pool.
Topics: Antiviral Agents; Aspartic Acid; Cell Survival; Cytidine Triphosphate; DNA-Directed RNA Polymerases; Gene Expression Regulation, Viral; HeLa Cells; Humans; Kinetics; Macromolecular Substances; Phosphonoacetic Acid; Pyrimidine Nucleotides; RNA, Messenger; Transcription, Genetic; Uridine; Uridine Triphosphate; Vaccinia virus; Virus Replication | 1997 |
Half of Saccharomyces cerevisiae carbamoyl phosphate synthetase produces and channels carbamoyl phosphate to the fused aspartate transcarbamoylase domain.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Feedback; Multienzyme Complexes; Phosphonoacetic Acid; Phosphotransferases (Carboxyl Group Acceptor); Plasmids; Pyrimidines; Saccharomyces cerevisiae; Uridine Triphosphate | 1999 |
Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis.
Topics: Animals; Apoptosis; Aspartic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Caspase 3; Caspases; Cell Line; Drug Resistance; Enzyme Inhibitors; Humans; Interleukin-3; Mice; Peptide Hydrolases; Phosphonoacetic Acid; Protein Structure, Tertiary; Staurosporine; Tumor Cells, Cultured; Uridine Triphosphate | 2002 |
Aspartate transcarbamylase from the hyperthermophilic archaeon Pyrococcus abyssi. Insights into cooperative and allosteric mechanisms.
Topics: Adenosine Triphosphate; Allosteric Regulation; Allosteric Site; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Catalysis; Cytidine Triphosphate; Escherichia coli; Phosphonoacetic Acid; Pyrococcus abyssi; Recombinant Proteins; Uridine Triphosphate | 2005 |