phosphatidylinositol-4-phosphate has been researched along with sphingosine-kinase* in 1 studies
1 other study(ies) available for phosphatidylinositol-4-phosphate and sphingosine-kinase
| Article | Year |
|---|---|
Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?
Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney tissue might be involved in the progression of chronic kidney disease.. Membrane fractions from kidney homogenates of undernourished rats (RBD) were submitted to lipid extraction and analysis by thin layer chromatography and cholesterol determination.. Kidneys from RBD rats had 25% lower cholesterol content, which disturb membrane microdomains, affecting Ca. Results point to an imbalance in the bioactive lipid generation with further consequences to key events related to kidney function, thus contributing to the establishment of chronic kidney disease. Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Animals, Newborn; Ceramides; Cholesterol; Diacylglycerol Kinase; Gene Expression Regulation; Hypertension; Kidney; Lipid Metabolism; Male; Malnutrition; Membrane Microdomains; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phospholipases A2; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Renal Insufficiency, Chronic | 2017 |