phosphatidylethanol and phorbol-12-13-didecanoate

phosphatidylethanol has been researched along with phorbol-12-13-didecanoate* in 1 studies

Other Studies

1 other study(ies) available for phosphatidylethanol and phorbol-12-13-didecanoate

Article	Year
Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:24 Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects. Topics: Adult; Alcoholism; Enzyme Activation; Glycerophospholipids; Humans; Male; Phorbol Esters; Phosphatidic Acids; Phospholipase D; Protein Kinase C	1988

Article

Year

Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism.

Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:24

Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.

Topics: Adult; Alcoholism; Enzyme Activation; Glycerophospholipids; Humans; Male; Phorbol Esters; Phosphatidic Acids; Phospholipase D; Protein Kinase C

1988