Page last updated: 2024-09-05

phosphatidylcholines and verapamil

phosphatidylcholines has been researched along with verapamil in 28 studies

Compound Research Comparison

Studies
(phosphatidylcholines)
Trials
(phosphatidylcholines)
Recent Studies (post-2010)
(phosphatidylcholines)
Studies
(verapamil)
Trials
(verapamil)
Recent Studies (post-2010) (verapamil)
32,2044435,59317,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyphosphatidylcholines (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.29)18.7374
1990's14 (50.00)18.2507
2000's5 (17.86)29.6817
2010's4 (14.29)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Barsoum, GH; Kappas, AM; Keighley, MR; Ortiz, JB1
Mason, RP; Moisey, DM; Shajenko, L1
Misík, V; Ondrias, K; Reguli, J; Stasko, A; Svajdlenka, E1
Byers, DM; Cook, HW; George, TP; Palmer, FB; Spence, MW1
Ramu, A; Ramu, N; Rosario, LM1
Buyukuysal, RL; Wurtman, RJ1
Gergel, D; Misík, V; Ondrias, K; Stasko, A1
Sanghera, JS; Vance, DE1
Cookson, JC1
Bennett, AJ; Brindley, DN; Graham, A; McLean, AA; Zammit, VA1
Cordes, HP; Pajeva, IK; Seydel, JK; Wiese, M1
Borst, P; Fritzsche, I; Schinkel, AH; Smith, AJ; Sprong, H; van Helvoort, A; van Meer, G1
Kobusiewicz, W; Ledwozyw, A; Michalak, J; Ogonowska-Kobusiewicz, M1
Brown, MK; Horton, RA; Mustacich, DJ; Reed, DJ; Shields, J1
Mason, PE; Mason, RP; Olmstead, EG; Trumbore, MW; Walter, MF1
Romsicki, Y; Sharom, FJ1
Herrmann, A; Lang, C; Marx, U; Nelson, H; Nelson, N; Polakowski, T; Pomorski, T1
Abulrob, AG; Gumbleton, M1
Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E1
Bevers, EM; Comfurius, P; Dekkers, DW; van Gool, RG; Zwaal, RF1
Ehehalt, R; Fitscher, BA; Herrmann, T; Jochims, C; Pohl, J; Stremmel, W1
Dhalla, NS; Kawabata, K; Nijjar, MS; Okumura, K; Panagia, V; Shah, KR; Tappia, PS1
Pajeva, I; Seydel, J; Todorov, DK1
Frantsuzova, SB; Khromov, OS; Strielkov, IeV1
Alvarez-Figueroa, MJ; Contreras-Garrido, BC; Soto-Arriaza, MA1
Cai, L; He, K; Liu, H; Shi, Q; Woolf, TF1
Burhenne, J; Fricker, G; Mylius, P; Schubert, R; Weinheimer, M1
Błaszczyk, M; Palko-Łabuz, A; Środa-Pomianek, K; Wesołowska, O1

Reviews

2 review(s) available for phosphatidylcholines and verapamil

ArticleYear
Drug treatment of bipolar depression and mania.
    British journal of hospital medicine, 1985, Volume: 34, Issue:3

    Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Bromocriptine; Carbamazepine; Cholinesterase Inhibitors; Clonidine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium; Monoamine Oxidase Inhibitors; Phosphatidylcholines; Tryptophan; Valproic Acid; Verapamil

1985
[Hypoxic pulmonary hypertension: modern views on pathogenesis and options for rational pharmacological correction].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2012, Volume: 58, Issue:2

    Topics: Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels; Humans; Hypertension, Pulmonary; Hypoxia; Liposomes; Phosphatidylcholines; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Sulfones; Vasodilator Agents; Ventricular Dysfunction, Right; Verapamil

2012

Other Studies

26 other study(ies) available for phosphatidylcholines and verapamil

ArticleYear
Prevention of peritoneal adhesions in rats with verapamil, hydrocortisone sodium succinate, and phosphatidylcholine.
    The European journal of surgery = Acta chirurgica, 1992, Volume: 158, Issue:1

    Topics: Animals; Female; Hydrocortisone; Peritoneal Diseases; Peritoneal Lavage; Phosphatidylcholines; Postoperative Complications; Rats; Rats, Inbred Strains; Sodium Chloride; Tissue Adhesions; Verapamil

1992
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
    Molecular pharmacology, 1992, Volume: 41, Issue:2

    Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil

1992
Comparison of perturbation effect of propranolol, verapamil, chlorpromazine and carbisocaine on lecithin liposomes and brain total lipid liposomes. An EPR spectroscopy study.
    Chemico-biological interactions, 1991, Volume: 79, Issue:2

    Topics: Animals; Brain; Carbamates; Chlorpromazine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Liposomes; Molecular Weight; Phosphatidylcholines; Phospholipids; Propranolol; Rats; Verapamil

1991
Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: potential regulation of biosynthesis by Ca(2+)-dependent mechanisms.
    Biochimica et biophysica acta, 1991, Jul-09, Volume: 1084, Issue:2

    Topics: Animals; Biological Transport, Active; Calcium; Carbon Radioisotopes; Cell Line; Choline; Cytochalasin B; Deoxyglucose; Ethanolamine; Ethanolamines; Glioma; Glucose; Kinetics; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorus Radioisotopes; Rats; Tritium; Verapamil

1991
Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine.
    Biochemical pharmacology, 1991, May-15, Volume: 41, Issue:10

    Topics: Animals; Cell Membrane; Cell Membrane Permeability; Choline; Digitonin; Dipyridamole; Drug Resistance; Fura-2; Ionomycin; Leukemia P388; Lipids; Phosphatidylcholines; Potassium Chloride; Tamoxifen; Tumor Cells, Cultured; Valinomycin; Verapamil

1991
4-Aminopyridine increases acetylcholine release without diminishing membrane phosphatidylcholine.
    Journal of neurochemistry, 1990, Volume: 54, Issue:4

    Topics: 4-Aminopyridine; Acetylcholine; Animals; Calcium; Carbon Radioisotopes; Corpus Striatum; Hemicholinium 3; In Vitro Techniques; Male; Membranes; Phosphatidylcholines; Phospholipids; Rats; Rats, Inbred Strains; Tetrodotoxin; Verapamil

1990
Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic-antihypoxic drug stobadine.
    Biochimica et biophysica acta, 1989, Jun-28, Volume: 1003, Issue:3

    Topics: Anti-Arrhythmia Agents; Carbolines; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Lipid Peroxides; Liposomes; Nifedipine; Phosphatidylcholines; Verapamil

1989
Stimulation of CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis by calcium in rat hepatocytes.
    Biochimica et biophysica acta, 1989, Jun-28, Volume: 1003, Issue:3

    Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Choline-Phosphate Cytidylyltransferase; Cytosol; Digitonin; Female; In Vitro Techniques; Liver; Microsomes, Liver; Nucleotidyltransferases; Phosphatidylcholines; Rats; Solubility; Vasopressins; Verapamil

1989
Factors regulating the secretion of lysophosphatidylcholine by rat hepatocytes compared with the synthesis and secretion of phosphatidylcholine and triacylglycerol. Effects of albumin, cycloheximide, verapamil, EGTA and chlorpromazine.
    The Biochemical journal, 1988, Aug-01, Volume: 253, Issue:3

    Topics: Albumins; Animals; Cells, Cultured; Chlorpromazine; Choline; Cycloheximide; Egtazic Acid; Glycerol; Liver; Lysophosphatidylcholines; Oleic Acid; Oleic Acids; Phosphatidylcholines; Rats; Triglycerides; Verapamil

1988
Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability.
    Journal of cancer research and clinical oncology, 1996, Volume: 122, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Dopamine Antagonists; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flupenthixol; Heterocyclic Compounds; Humans; Leukemia P388; Magnetic Resonance Spectroscopy; Membranes, Artificial; Mice; Phosphatidylcholines; Phosphatidylserines; Verapamil

1996
MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.
    Cell, 1996, Nov-01, Volume: 87, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Line; Cell Polarity; Epithelium; Humans; Kidney; Lipid Metabolism; Lipids; Mice; Phosphatidylcholines; Recombinant Fusion Proteins; Substrate Specificity; Swine; Transfection; Verapamil; Vincristine

1996
The influence of nifedipine and verapamil on the ischaemia-induced changes in canine sarcolemmal membranes.
    Archivum veterinarium Polonicum, 1995, Volume: 35, Issue:1-2

    Topics: Animals; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Membrane; Dog Diseases; Dogs; Electron Transport Complex IV; Heart; Male; Membrane Proteins; Myocardial Ischemia; Myocardium; N-Acetylneuraminic Acid; Nifedipine; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Sarcolemma; Sodium-Potassium-Exchanging ATPase; Verapamil

1995
Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice.
    Archives of biochemistry and biophysics, 1998, Feb-15, Volume: 350, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Carbon Radioisotopes; Female; Glutathione; Glutathione Disulfide; Liver; Male; Mice; Mice, Knockout; Phosphatidylcholines; Piperonyl Butoxide; Rats; Rats, Sprague-Dawley; Verapamil; Vitamin E

1998
Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Amlodipine; Antihypertensive Agents; Antioxidants; Calcium; Calorimetry, Differential Scanning; Diltiazem; Dimyristoylphosphatidylcholine; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Inhibitory Concentration 50; Lipid Peroxidation; Phosphatidylcholines; Verapamil

1999
The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter.
    Biochemistry, 1999, May-25, Volume: 38, Issue:21

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Adenosine Triphosphatases; Anilino Naphthalenesulfonates; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; CHO Cells; Cricetinae; Dimyristoylphosphatidylcholine; Drug Interactions; Enzyme Inhibitors; Humans; Membrane Lipids; Phosphatidylcholines; Protein Binding; Receptors, Drug; Spectrometry, Fluorescence; Sulfhydryl Reagents; Verapamil; Vinblastine

1999
Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis-deficient yeast cells does not require the Drs2 protein.
    European journal of biochemistry, 1999, Volume: 263, Issue:1

    Topics: 4-Chloro-7-nitrobenzofurazan; Adenosine Triphosphate; Biological Transport, Active; Calcium-Transporting ATPases; Cell Membrane; Endocytosis; Ethylmaleimide; Fluorescent Dyes; Fungal Proteins; Gene Deletion; Genes, Fungal; Lipid Bilayers; Liposomes; Mutation; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vanadates; Verapamil

1999
Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.
    Biochemical and biophysical research communications, 1999, Aug-19, Volume: 262, Issue:1

    Topics: 4-Chloro-7-nitrobenzofurazan; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Doxorubicin; Drug Resistance, Neoplasm; Epithelial Cells; Flow Cytometry; Fluorescent Dyes; Humans; Kinetics; Phenotype; Phosphatidylcholines; Rhodamine 123; RNA, Messenger; Tumor Cells, Cultured; Verapamil

1999
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
    The Journal of biological chemistry, 2000, Aug-04, Volume: 275, Issue:31

    Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine

2000
Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: 4-Chloro-7-nitrobenzofurazan; Aminocaproates; Aminocaproic Acid; Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Cell Membrane; Erythrocytes; Fluorescent Dyes; Humans; Hydrolysis; Indomethacin; Lipid Bilayers; Microscopy, Electron; Multidrug Resistance-Associated Proteins; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Sphingomyelin Phosphodiesterase; Time Factors; Vasodilator Agents; Verapamil

2000
Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system.
    European journal of medical research, 2000, Dec-29, Volume: 5, Issue:12

    Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Western; Calcium Channel Blockers; Choline; Cloning, Molecular; Cyclosporins; DNA, Complementary; Doxycycline; Drug Resistance, Multiple; Gene Expression Regulation; HeLa Cells; Hepatocytes; Humans; Immunohistochemistry; Luciferases; Phosphatidylcholines; Rabbits; Taurocholic Acid; Tritium; Verapamil

2000
Ca2+-antagonists inhibit the N-methyltransferase-dependent synthesis of phosphatidylcholine in the heart.
    Molecular and cellular biochemistry, 2001, Volume: 221, Issue:1-2

    Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Dose-Response Relationship, Drug; Heart; Male; Methylation; Methyltransferases; Mitochondria, Heart; Myocardium; Organ Culture Techniques; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sarcolemma; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Verapamil

2001
Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 21, Issue:2-3

    Topics: Antibiotics, Antineoplastic; Aporphines; Benzylisoquinolines; Calorimetry, Differential Scanning; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flupenthixol; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Phosphatidylserines; Verapamil

2004
Use of DMPC and DSPC lipids for verapamil and naproxen permeability studies by PAMPA.
    Drug development and industrial pharmacy, 2015, Volume: 41, Issue:4

    Topics: Absorption, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cell Membrane Permeability; Cholesterol; Dimyristoylphosphatidylcholine; Humans; Kinetics; Lecithins; Membranes, Artificial; Models, Biological; Naproxen; Permeability; Phosphatidylcholines; Verapamil

2015
Inhibition of MDR3 Activity in Human Hepatocytes by Drugs Associated with Liver Injury.
    Chemical research in toxicology, 2015, Oct-19, Volume: 28, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Deuterium; Hepatocytes; Humans; Itraconazole; Phosphatidylcholines; Tandem Mass Spectrometry; Taurocholic Acid; Verapamil

2015
The application of P-gp inhibiting phospholipids as novel oral bioavailability enhancers - An in vitro and in vivo comparison.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Oct-15, Volume: 108

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Drug Delivery Systems; Humans; Intestinal Absorption; Male; Phosphatidylcholines; Phospholipids; Polysorbates; Rats, Wistar; Rhodamine 123; Ritonavir; Surface-Active Agents; Verapamil

2017
Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter.
    Molecules (Basel, Switzerland), 2021, Jul-30, Volume: 26, Issue:15

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Binding, Competitive; Cell Line, Tumor; Chalcones; Dogs; Doxorubicin; Drug Combinations; Drug Resistance, Neoplasm; Gene Expression; HT29 Cells; Humans; Inhibitory Concentration 50; Lipid Bilayers; Madin Darby Canine Kidney Cells; Membranes, Artificial; Models, Molecular; Phosphatidylcholines; Plant Extracts; Plants, Medicinal; Protein Binding; Psoralea; Transgenes; Verapamil

2021