phosphatidylcholines has been researched along with topotecan in 6 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (topotecan) | Trials (topotecan) | Recent Studies (post-2010) (topotecan) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 2,392 | 626 | 792 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | topotecan (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 1.5211 | |
| DNA topoisomerase 1 | Homo sapiens (human) | 0.8525 | |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | 0.605 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.605 | |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 0.06 | |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 8.6 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.3 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burke, TG; Gao, X | 1 |
| Alnajim, J; Anantha, M; Bally, MB; Ramsay, E; Taggar, AS; Thomas, A; Webb, M | 1 |
| Deng, Y; Li, T; Wang, N; Wang, T | 2 |
| Anderson, BD; Fugit, KD | 1 |
| Lopes-de-Araújo, J; Nunes, C; Reis, S | 1 |
6 other study(ies) available for phosphatidylcholines and topotecan
| Article | Year |
|---|---|
Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine.
Topics: Antineoplastic Agents; Buffers; Camptothecin; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Carriers; Drug Stability; Humans; Hydrogen-Ion Concentration; Lactones; Liposomes; Phosphatidylcholines; Topotecan | 1994 |
Copper-topotecan complexation mediates drug accumulation into liposomes.
Topics: Buffers; Calcimycin; Cations, Divalent; Chemical Precipitation; Cholesterol; Copper; Cryoelectron Microscopy; Doxorubicin; Drug Compounding; Hydrogen-Ion Concentration; Lactones; Liposomes; Manganese Compounds; Molecular Structure; Nigericin; Phosphatidylcholines; Proton-Motive Force; Sulfates; Topotecan | 2006 |
Freeze drying of double emulsions to prepare topotecan-entrapping liposomes featuring controlled release.
Topics: Antineoplastic Agents; Cholesterol; Delayed-Action Preparations; Drug Stability; Drug Storage; Emulsions; Freeze Drying; Glycine max; Hydrogen-Ion Concentration; Liposomes; Phosphatidylcholines; Topotecan | 2008 |
Modulation of the physicochemical state of interior agents to prepare controlled release liposomes.
Topics: Chemical Phenomena; Cholesterol; Delayed-Action Preparations; Drug Stability; Emulsions; Liposomes; Microscopy, Electron, Transmission; Phosphatidylcholines; Scattering, Small Angle; Solubility; Topotecan; X-Ray Diffraction | 2009 |
The role of pH and ring-opening hydrolysis kinetics on liposomal release of topotecan.
Topics: Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Topoisomerase I Inhibitors; Topotecan | 2014 |
Topotecan effect on the structure of normal and cancer plasma membrane lipid models: A multi-model approach.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Dimyristoylphosphatidylcholine; Humans; Membranes, Artificial; Models, Biological; Molecular Structure; Neoplasms; Phosphatidylcholines; Phosphatidylserines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topotecan | 2018 |