phosphatidylcholines has been researched along with tacrine in 25 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (tacrine) | Trials (tacrine) | Recent Studies (post-2010) (tacrine) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 2,141 | 161 | 643 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | tacrine (IC50) |
|---|---|---|---|
| Chain A, ACETYLCHOLINESTERASE | Tetronarce californica (Pacific electric ray) | 0.0082 | |
| Solute carrier family 22 member 2 | Homo sapiens (human) | 0.68 | |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.1401 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.1691 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.0456 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.7875 | |
| Cytochrome P450 2E1 | Homo sapiens (human) | 0.075 | |
| Cholinesterase | Homo sapiens (human) | 0.0545 | |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | 0.047 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.517 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 6.6 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 6.6 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 6.6 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.1084 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 6.6 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.0457 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.3 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 6.6 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.0457 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.078 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.1957 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 0.0835 | |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | 0.047 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 0.1143 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.2576 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.1848 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.517 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.1143 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.2097 | |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | 0.042 | |
| Cholinesterase | Equus caballus (horse) | 0.1103 | |
| Histamine N-methyltransferase | Rattus norvegicus (Norway rat) | 0.11 | |
| Cholinesterase | Mus musculus (house mouse) | 0.0625 | |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | 0.044 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 6.3 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 6.3 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.267 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.1 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.0995 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 0.0143 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 18 (72.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolezal, V; Tucek, S | 1 |
| Fitten, LJ; Ganzell, S | 1 |
| Cohen, MB; Fitten, LJ; Graham, LS; Lake, RR; Perryman, KM; Sevrin, R | 1 |
| Eagger, SA; Levy, R; Sahakian, BJ | 1 |
| Teunisse, S; van Gool, WA; Weinstein, HC | 1 |
| Volger, BW | 1 |
| Chatellier, G; Lacomblez, L | 1 |
| Bacher, Y; Bailey, P; Bergman, H; Bouchard, R; Carrier, L; Gauthier, S; Lamontagne, A; Ratner, J; Saint-Martin, M; Tesfaye, Y | 1 |
| Levy, R | 1 |
| Cummins, J; Fine, H; Fitten, LJ; Gross, PL; Marshall, C; Perryman, KM | 1 |
| Gauthier, L; Gauthier, S; Vida, S | 1 |
| Bacher, Y; Bailey, P; Bergman, H; Bouchard, R; Carrier, L; Charbonneau, R; Clarfield, M; Collier, B; Dastoor, D; Gauthier, S | 1 |
| Boller, F; Forette, F | 1 |
| Ebert, MH; Gillin, JC; Kaye, WH; Sitaram, N; Smallberg, S; Weingartner, H | 1 |
| Holford, NH; Peace, K | 1 |
| Broe, GA; Brooks, WS; Christensen, H; Creasey, H; Jorm, AF; Maltby, N | 1 |
| Boyle, M; Mulligan, K; Neubauer, KA; O'Neill, D; Royston, VH; Scott, M; Surmon, DJ; Wilcock, GK | 1 |
| Gauthier, L; Gauthier, S | 1 |
| Fitten, LJ; Perryman, KM | 1 |
| Kinnunen, PK; Lehtonen, JY; Rytömaa, M | 1 |
| di Fazio, I; Malaguarnera, M; Motta, M; Pistone, G; Rampello, L; Vinci, M | 1 |
| Butler, R; Prabhakaran, P; Warner, J | 1 |
| Sakikawa, T; Shimazaki, Y | 1 |
| Barbero, F; Berti, D; Cutillo, L; Gonzalez-Paredes, A; Mamusa, M; Montis, C | 1 |
6 review(s) available for phosphatidylcholines and tacrine
| Article | Year |
|---|---|
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; Humans; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials.
Topics: Alzheimer Disease; Cognition; Disease Progression; Drug Therapy, Combination; Humans; Phosphatidylcholines; Tacrine | 1994 |
What have we learned from the THA trials to facilitate testing of new AChE inhibitors.
Topics: Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Diseases; Humans; Phosphatidylcholines; Psychological Tests; Research Design; Tacrine; Treatment Outcome | 1993 |
Tacrine treatment of Alzheimer's disease: many expectations, few certainties.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nootropic Agents; Odds Ratio; Phosphatidylcholines; Quality of Life; Randomized Controlled Trials as Topic; Tacrine | 1998 |
Dementia.
Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E | 2003 |
12 trial(s) available for phosphatidylcholines and tacrine
| Article | Year |
|---|---|
SPECT brain imaging in Alzheimer's disease during treatment with oral tetrahydroaminoacridine and lecithin.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Amphetamines; Brain; Cerebrovascular Circulation; Double-Blind Method; Humans; Iodine Radioisotopes; Iofetamine; Middle Aged; Phosphatidylcholines; Tacrine; Tomography, Emission-Computed, Single-Photon | 1992 |
Tacrine in Alzheimer's disease.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aptitude Tests; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Intelligence; Intelligence Tests; Liver Function Tests; Male; Middle Aged; Phosphatidylcholines; Pilot Projects; Severity of Illness Index; Tacrine | 1991 |
Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers.
Topics: Aged; Alzheimer Disease; Behavior; Cognition; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Psychological Tests; Quality of Life; Tacrine | 1991 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Behavior; Chemical and Drug Induced Liver Injury; Cognition; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phosphatidylcholines; Psychological Tests; Randomized Controlled Trials as Topic; Tacrine | 1990 |
Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Cholinesterase Inhibitors; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Intelligence Tests; Male; Middle Aged; Multicenter Studies as Topic; Patient Compliance; Phosphatidylcholines; Randomized Controlled Trials as Topic; Tacrine | 1990 |
Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study.
Topics: Aged; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Male; Phosphatidylcholines; Tacrine | 1990 |
Canadian collaborative study of tetrahydroaminoacridine (THA) and lecithin treatment of Alzheimer's disease: effect on mood.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Tacrine | 1989 |
Progress report on the Canadian Multicentre Trial of tetrahydroaminoacridine with lecithin in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Canada; Clinical Trials as Topic; Drug Combinations; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; Humans; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial.
Topics: Activities of Daily Living; Affect; Aged; Aged, 80 and over; Alzheimer Disease; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Tacrine; Treatment Outcome | 1994 |
Delayed matching-to-sample performance during a double-blind trial of tacrine (THA) and lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Cognition; Double-Blind Method; Humans; Male; Phosphatidylcholines; Psychomotor Performance; Tacrine | 1993 |
9 other study(ies) available for phosphatidylcholines and tacrine
| Article | Year |
|---|---|
Investigation of the mechanism of the effect of tacrine (tetrahydroaminoacridine) on the metabolism of acetylcholine and choline in brain cortical prisms.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Cerebral Cortex; Choline; Hemicholinium 3; In Vitro Techniques; Male; Nerve Endings; Paraoxon; Phosphatidylcholines; Phosphorylation; Phosphorylcholine; Rats; Rats, Wistar; Tacrine | 1992 |
Spouses' assessments of Alzheimer patients' response to THA and lecithin.
Topics: Alzheimer Disease; Attitude to Health; Caregivers; Drug Therapy, Combination; Female; Humans; Male; Phosphatidylcholines; Tacrine | 1992 |
Are drugs targeted at Alzheimer's disease useful? 1. Useful for what?
Topics: Aged; Alzheimer Disease; Drug Therapy, Combination; Humans; Phosphatidylcholines; Tacrine | 1990 |
Tetrahydroaminoacridine and lecithin for Alzheimer's disease.
Topics: Alzheimer Disease; Aminoacridines; Humans; Phosphatidylcholines; Research Design; Tacrine | 1990 |
Modest facilitation on memory in dementia with combined lecithin and anticholinerestase treatment.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Drug Therapy, Combination; Humans; Memory; Middle Aged; Phosphatidylcholines; Pilot Projects; Placebos; Serial Learning; Tacrine; Wechsler Scales | 1982 |
An evaluation of the efficacy and safety of tetrahydroaminoacridine (THA) without lecithin in the treatment of Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Male; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Quality of Life; Tacrine | 1993 |
Characteristics of the binding of tacrine to acidic phospholipids.
Topics: Cholinesterase Inhibitors; Dimyristoylphosphatidylcholine; Kinetics; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylglycerols; Phosphatidylinositols; Phospholipids; Sphingosine; Structure-Activity Relationship; Tacrine | 1996 |
Reversible inhibition of esterase activity after separation and immobilization.
Topics: Electrophoresis, Gel, Two-Dimensional; Enzymes, Immobilized; Esterases; Hydrolysis; Phosphatidylcholines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tacrine | 2011 |
Inclusion of oligonucleotide antimicrobials in biocompatible cationic liposomes: A structural study.
Topics: Anti-Infective Agents; Cations; Liposomes; Oligonucleotides; Phosphatidylcholines; Phosphatidylethanolamines; Tacrine | 2017 |