phosphatidylcholines has been researched along with miltefosine in 30 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (miltefosine) | Trials (miltefosine) | Recent Studies (post-2010) (miltefosine) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 1,330 | 83 | 769 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | miltefosine (IC50) |
|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 9.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (53.33) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Geilen, CC; Reutter, W; Wieder, T | 2 |
| Berger, MR; Eibl, H; Kötting, J; Unger, C | 1 |
| Geilen, CC; Haase, R; Reutter, W; Wieder, T | 1 |
| Kotsinas, A; Maurer, HR; Patsilinacos, P; Spandidos, DA; Zoumpourlis, V | 1 |
| Geilen, CC; Haase, A; Orfanos, CE; Wieder, T | 1 |
| Geilen, CC; Haase, A; Morré, DJ; Morré, DM; Reutter, W; Wieder, T | 1 |
| Detmar, M; Geilen, CC; Orfanos, CE; Reutter, W; Wieder, T | 1 |
| Colombo, DT; Reitz, RC; Tran, LK | 1 |
| Campenot, RB; Posse de Chaves, E; Vance, DE; Vance, JE | 1 |
| Almond-Roesler, B; Blume-Peytavi, U; Geilen, CC; Orfanos, CE; Sommer, C | 1 |
| Arndt, D; Eue, I; Fichtner, I; Sternberg, B; Zeisig, R | 1 |
| Boggs, K; Jackowski, S; Rock, CO | 1 |
| Chaimovich, H; da Costa, MH | 1 |
| Dittrich, N; Haftendorn, R; Ulbrich-Hofmann, R | 1 |
| Geilen, CC; Orfanos, CE; Wieder, T | 1 |
| Adamo, S; Coletti, D; Molinaro, M; Palleschi, S; Silvestroni, L; Tomei, F | 1 |
| Carrasco, MP; Jiménez-López, JM; Marco, C; Segovia, JL | 2 |
| Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW | 1 |
| Duijsings, D; Houweling, M; Vaandrager, AB; van der Sanden, MH; van Golde, LM | 1 |
| Murray, HW | 1 |
| Bories, C; Demetzos, C; Loiseau, PM; Papagiannaros, A | 1 |
| Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T | 1 |
| Andrade, Ida S; Catta-Preta, CM; Cavalcanti, DP; de Freitas-Junior, PR; de Souza, W; Einicker-Lamas, M; Motta, MC | 1 |
| Bosschaerts, T; Caridha, DP; Fortin, A; Grogl, M; Hickman, MR; Hudson, TH; Leed, S; Ngundam, F; Parriott, S; Sena, J | 1 |
| Blankschtein, D; de Sá, MM; Rangel-Yagui, CO; Sresht, V | 1 |
| Alim, D; Andes, DR; Bapat, P; Husain, F; Nobile, CJ; Panwar, SL; Rastogi, S; Ror, S; Sircaik, S; Srivastava, A; Thomas, E | 1 |
| Carrer, DC; Moody, D; Peralta, MF; Smith, H; Tristram-Nagle, S | 1 |
| Alonso, A; Alonso, L; Kipnis, A; Pimenta, LKL | 1 |
2 review(s) available for phosphatidylcholines and miltefosine
| Article | Year |
|---|---|
Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis.
Topics: Animals; Apoptosis; CHO Cells; Cricetinae; Phosphatidylcholines; Phosphorylcholine | 2004 |
Progress in the treatment of a neglected infectious disease: visceral leishmaniasis.
Topics: Amphotericin B; Antimony; Antiprotozoal Agents; Clinical Trials as Topic; Deoxycholic Acid; Drug Combinations; Drug Costs; Humans; Leishmaniasis, Visceral; Paromomycin; Phosphatidylcholines; Phosphatidylglycerols; Phosphorylcholine; Practice Guidelines as Topic | 2004 |
28 other study(ies) available for phosphatidylcholines and miltefosine
| Article | Year |
|---|---|
Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.
Topics: Animals; Biological Transport; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Diglycerides; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate | 1992 |
Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Phosphatidylcholines; Phosphorylcholine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tissue Distribution | 1992 |
The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
Topics: Animals; Cell Line; Choline; Dogs; Kinetics; N-Acylneuraminate Cytidylyltransferase; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorylcholine | 1991 |
Transcriptional activation of the human immunodeficiency virus long terminal repeat sequences by cis-platin.
Topics: Acquired Immunodeficiency Syndrome; Cell Line; Chloramphenicol O-Acetyltransferase; Cisplatin; Ethylenediamines; Genetic Markers; HIV Long Terminal Repeat; HIV-1; Humans; Kanamycin Kinase; Phosphatidylcholines; Phosphorylcholine; Phosphotransferases; Plasmids; Transcriptional Activation; Transfection; Virus Replication | 1990 |
The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Cell Division; Cell Line; Choline-Phosphate Cytidylyltransferase; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine | 1995 |
Uptake, subcellular distribution and metabolism of the phospholipid analogue hexadecylphosphocholine in MDCK cells.
Topics: Animals; Carbon Radioisotopes; Cell Division; Cell Line; Cell Membrane; Phosphatidylcholines; Phosphorylcholine; Subcellular Fractions; Temperature; Time Factors | 1994 |
Phospholipid analogue hexadecylphosphocholine inhibits proliferation and phosphatidylcholine biosynthesis of human epidermal keratinocytes in vitro.
Topics: Cell Division; Choline-Phosphate Cytidylyltransferase; Humans; Keratinocytes; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Protein Biosynthesis; Proteins | 1994 |
The effects of hexadecylphosphocholine (HPC) a mixture of alkylphosphocholines (APC) and different dietary oils on the growth of a human mammary tumor.
Topics: Animals; Breast Neoplasms; Corn Oil; Dietary Fats, Unsaturated; Dinoprostone; Fish Oils; Humans; Mice; Neoplasm Transplantation; Phosphatidylcholines; Phosphorylcholine; Structure-Activity Relationship | 1993 |
Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Digitonin; Diglycerides; Dogs; HeLa Cells; Humans; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Tetradecanoylphorbol Acetate | 1993 |
Alkylphosphocholines inhibit choline uptake and phosphatidylcholine biosynthesis in rat sympathetic neurons and impair axonal extension.
Topics: Animals; Animals, Newborn; Axons; Biological Transport; Cells, Cultured; Choline; Choline-Phosphate Cytidylyltransferase; Enzyme Inhibitors; Kinetics; Neurons; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate | 1995 |
The phospholipid analogue hexadecylphosphocholine (HePC) inhibits proliferation of keloid fibroblasts in vitro and modulates their fibronectin and integrin synthesis.
Topics: Cell Division; Cells, Cultured; Collagen; Extracellular Matrix; Fibroblasts; Fibronectins; Humans; Integrins; Keloid; Male; Phosphatidylcholines; Phosphorylcholine; Reference Values | 1997 |
Antineoplastic activity of sterically stabilized alkylphosphocholine liposomes in human breast carcinomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Survival; Cholesterol; Ethanolamines; Humans; Liposomes; Metabolic Clearance Rate; Mice; Phosphatidylcholines; Phosphorylcholine; Polyethylene Glycols; Receptors, Estrogen; Tumor Cells, Cultured | 1997 |
The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Recombinant Proteins | 1998 |
Structure-activity relationships in the fusion of small unilamellar phosphatidylcholine vesicles induced by a model peptide.
Topics: Animals; Circular Dichroism; Hydrogen-Ion Concentration; Membrane Fusion; Phosphatidylcholines; Phosphorylcholine; Protein Structure, Secondary; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1997 |
Hexadecylphosphocholine and 2-modified 1,3-diacylglycerols as effectors of phospholipase D.
Topics: Brassica; Diglycerides; Kinetics; Models, Biological; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Sodium Dodecyl Sulfate; Substrate Specificity; Surface-Active Agents | 1998 |
Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine.
Topics: Antineoplastic Agents; Apoptosis; Carboxylic Acids; Cell Division; Cell Line; Ceramides; Fumonisins; Phosphatidylcholines; Phosphorylcholine; Sphingomyelins | 1998 |
Surface remodeling associated with vasopressin-induced membrane traffic in L6 myogenic cells.
Topics: Acridine Orange; Acrylamide; Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line; Cell Membrane; Cell Movement; Cytochalasin B; Enzyme Inhibitors; Exocytosis; Fluorescent Dyes; Fluorometry; Kinetics; Ligands; Microscopy, Electron; Microscopy, Electron, Scanning; Muscles; Paclitaxel; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phospholipids; Phosphorylcholine; Rats; Signal Transduction; Time Factors; Vasopressins; Wortmannin | 2000 |
Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells.
Topics: Antineoplastic Agents; Cell Division; Choline; Humans; Phosphatidylcholines; Phosphorylcholine; Tumor Cells, Cultured | 2002 |
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Dose-Response Relationship, Drug; Drug Resistance; Drug Resistance, Multiple; Endocytosis; Gene Deletion; Ketoconazole; Leishmaniasis; Lipid Metabolism; Lysophosphatidylcholines; Membrane Transport Proteins; Microscopy, Fluorescence; Mutation; Nuclear Envelope; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Point Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors | 2003 |
Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Ethanolamines; Humans; Methylation; Phosphatidylcholines; Phosphorylcholine | 2004 |
Antileishmanial and trypanocidal activities of new miltefosine liposomal formulations.
Topics: Amines; Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Stability; Inhibitory Concentration 50; Leishmania donovani; Liposomes; Mice; Particle Size; Phosphatidylcholines; Phosphorylcholine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2005 |
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic | 2007 |
Effects of miltefosine on the proliferation, ultrastructure, and phospholipid composition of Angomonas deanei, a trypanosomatid protozoan that harbors a symbiotic bacterium.
Topics: Bacteria; Cell Membrane; Cell Wall; Choline-Phosphate Cytidylyltransferase; Crithidia; Microscopy, Electron, Transmission; Mitochondria; Phosphatidylcholines; Phosphorus Isotopes; Phosphorylcholine; Symbiosis | 2012 |
Direct comparison of the efficacy and safety of oral treatments with oleylphosphocholine (OlPC) and miltefosine in a mouse model of L. major cutaneous leishmaniasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Leishmania major; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Phosphatidylcholines; Phosphorylcholine | 2014 |
Understanding Miltefosine-Membrane Interactions Using Molecular Dynamics Simulations.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; Cholesterol; Kinetics; Lipid Bilayers; Membrane Microdomains; Molecular Dynamics Simulation; Phosphatidylcholines; Phosphorylcholine; Thermodynamics; Water | 2015 |
Distinct roles of the 7-transmembrane receptor protein Rta3 in regulating the asymmetric distribution of phosphatidylcholine across the plasma membrane and biofilm formation in Candida albicans.
Topics: Animals; Antifungal Agents; Biofilms; Candida albicans; Catheters; Cell Membrane; Fungal Proteins; Gene Deletion; Membrane Proteins; Phosphatidylcholines; Phosphorylcholine; Rats | 2017 |
Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes.
Topics: Amphotericin B; Antiprotozoal Agents; Imiquimod; Indoles; Liposomes; Phosphatidylcholines; Phosphorylcholine; Sodium Cholate; X-Ray Diffraction | 2018 |
Mycobacterium abscessus cell wall and plasma membrane characterization by EPR spectroscopy and effects of amphotericin B, miltefosine and nerolidol.
Topics: Amphotericin B; Anti-Bacterial Agents; Cell Membrane; Cell Wall; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Microbial Sensitivity Tests; Mycobacterium abscessus; Phosphatidylcholines; Phosphorylcholine; Sesquiterpenes; Spin Labels; Stearic Acids | 2022 |