phosphatidylcholines has been researched along with methotrexate in 22 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 41,593 | 5,666 | 11,969 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | methotrexate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.8 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
| Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
| Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
| Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
| Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
| Thymidylate synthase | Homo sapiens (human) | 0.343 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
| Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
| Folate receptor beta | Homo sapiens (human) | 0.1585 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Reduced folate transporter | Homo sapiens (human) | 0.012 | |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
| Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (31.82) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Poirier, LA | 1 |
| Colley, CM; Ryman, BE | 1 |
| Abbà, L; Genghini, M; Knerich, R; Luisetti, M; Pagnoni, AM; Peona, V; Pozzi, E; Salmona, M; Villani, F | 1 |
| Nelson, GH | 1 |
| Fry, DW; Goldman, ID | 1 |
| Li, KQ; Lu, XP; Weng, GY; Xu, NN | 1 |
| Freise, J; Müller, WH; Rauch, S | 1 |
| Jain, NK; Khopade, AJ; Utreja, S | 1 |
| Berman, E; Cohen, JS; Mardor, Y; Ringel, I; Sterin, M | 1 |
| Jenski, LJ; Stillwell, W; Zerouga, M | 1 |
| Carlotti, ME; Gallarate, M; Peira, E; Trotta, M | 1 |
| Hockenberry, M; Hutter, J; Kaemingk, K; Krull, K; Miketova, P; Moore, IM; Pasvogel, A | 1 |
| du Plessis, J; Du Preez, J; Hadgraft, J; Ita, KB; Lane, ME | 1 |
| Hockenberry, M; Jain, N; Kaemingk, K; Krull, KR; Miketova, P; Moore, IM; Stenzel, SL | 1 |
| Bovin, NV; Grandfils, C; Kuznetsova, NR; Lespineux, D; Mészáros, T; Sevrin, C; Szebeni, J; Vodovozova, EL | 1 |
| Kanokpanont, S; Raktanonchai, U; Srisuk, P; Thongnopnua, P | 1 |
| Carey, M; Hockenberry, MJ; Krull, KR; Miketova, P; Moore, IM | 1 |
| Cha, JH; Kim, HS; Kim, JK; Qureshi, OS; Zeb, A | 1 |
| de Lange, ECM; Gaillard, PJ; Hammarlund-Udenaes, M; Hu, Y; Rip, J | 1 |
| Chen, D; Chen, Y; Hou, Z; Li, A; Li, Y; Liu, G; Ma, J; Zhou, X; Zhu, X | 1 |
| Chen, Y; Fei, WD; Wang, WX; Wang, XR; Zhao, YC; Zheng, CH; Zheng, HL; Zheng, XL; Zheng, YQ | 1 |
| Chandra, P; Dkhar, DS; Dubey, VK; Kumar, R; Kumari, R; Mahapatra, S; Prerna, K; Srivastava, VR | 1 |
22 other study(ies) available for phosphatidylcholines and methotrexate
| Article | Year |
|---|---|
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12 | 1975 |
Liposomes as carriers in vivo for methotrexate.
Topics: Animals; Binding Sites; Biological Transport; Cholesterol; Egg Yolk; Female; Kidney; Liposomes; Liver; Methotrexate; Organ Specificity; Phosphatidylcholines; Rats; Spleen; Time Factors | 1975 |
Ambroxol and pulmonary toxicity induced by antineoplastic drugs.
Topics: Ambroxol; Animals; Antineoplastic Agents; Bleomycin; Bromhexine; Busulfan; Cyclophosphamide; Humans; Lung Diseases; Lymphocytes; Macrophages; Methotrexate; Middle Aged; Neutrophils; Nitrosourea Compounds; Phosphatidylcholines; Procarbazine; Pulmonary Alveoli; Pulmonary Fibrosis; Rats; Respiratory Function Tests | 1986 |
Lecithin-sphingomyelin ratio changes with estrogen or glucocorticoid treatment.
Topics: Amniotic Fluid; Dexamethasone; Female; Humans; Methotrexate; Neoplasms; Phosphatidylcholines; Pregnancy; Sphingomyelins | 1973 |
Further studies on the charge-related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome-cell association.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Folic Acid; Folic Acid Antagonists; Kinetics; Liposomes; Methotrexate; Mice; Phosphatidylcholines; Structure-Activity Relationship | 1982 |
[Effects of lecithin quality on encapsulation ratio of MTX-liposome (author's transl)].
Topics: Liposomes; Methotrexate; Oxidation-Reduction; Phosphatidylcholines | 1982 |
Distribution of negatively charged liposomes on rat liver hepatocytes and non-hepatocytes in cell suspension.
Topics: Adsorption; Animals; Anions; Cell Survival; Cells, Cultured; Cholesterol; Liposomes; Liver; Male; Methotrexate; Phagocytosis; Pharmaceutical Vehicles; Phosphatidylcholines; Rats; Temperature | 1980 |
Lipoprotein-mimicking biovectorized systems for methotrexate delivery.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Drug Carriers; Drug Delivery Systems; Female; Folic Acid Antagonists; Lipoproteins; Male; Methotrexate; Molecular Mimicry; Phosphatidylcholines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility | 1999 |
Levels of phospholipid metabolites in breast cancer cells treated with antimitotic drugs: a 31P-magnetic resonance spectroscopy study.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Division; Cell Membrane; Collagen; Doxorubicin; Drug Combinations; G2 Phase; Laminin; Methotrexate; Mitosis; Nocodazole; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel; Phosphatidylcholines; Phospholipids; Phosphorus; Proteoglycans; Tumor Cells, Cultured; Vincristine | 2001 |
Synthesis of a novel phosphatidylcholine conjugated to docosahexaenoic acid and methotrexate that inhibits cell proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Chromatography, Gas; Docosahexaenoic Acids; Drug Synergism; Fatty Acids; Leukemia; Liposomes; Methotrexate; Mice; Phosphatidylcholines; Phospholipases A; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Deformable liposomes for dermal administration of methotrexate.
Topics: Administration, Cutaneous; Animals; Biological Transport; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Glycine max; Hydrogenation; In Vitro Techniques; Liposomes; Methotrexate; Permeability; Phosphatidylcholines; Skin; Swine; Tissue Distribution | 2004 |
Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Injections, Spinal; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants.
Topics: Acyclovir; Administration, Cutaneous; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Diffusion; Elasticity; Epidermis; Humans; Idoxuridine; Liposomes; Methotrexate; Microscopy, Electron, Transmission; Particle Size; Permeability; Phosphatidylcholines; Phospholipids; Skin; Skin Absorption; Structure-Activity Relationship; Surface-Active Agents | 2007 |
Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.
Topics: Adaptation, Psychological; Adolescent; Antineoplastic Agents; Brain; Child; Child Behavior; Child, Preschool; Female; Humans; Male; Methotrexate; Oxidation-Reduction; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer.
Topics: Animals; Blood Coagulation; Blood Platelets; Complement Activation; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; In Vitro Techniques; Lipid Bilayers; Liposomes; Melphalan; Methotrexate; Nanoparticles; Particle Size; Phosphatidylcholines; Phosphatidylinositols; Prodrugs; Surface Properties | 2012 |
Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment.
Topics: Administration, Cutaneous; Animals; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Dermatologic Agents; Diffusion Chambers, Culture; Drug Delivery Systems; Drug Stability; Electrochemistry; Half-Life; In Vitro Techniques; Liposomes; Methotrexate; Oleic Acid; Particle Size; Permeability; Phosphatidylcholines; Phospholipids; Psoriasis; Skin Absorption; Swine | 2012 |
Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Multivariate Analysis; Neuropsychological Tests; Outcome Assessment, Health Care; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sphingomyelins; Time Factors | 2013 |
Improved skin permeation of methotrexate via nanosized ultradeformable liposomes.
Topics: Administration, Cutaneous; Animals; Drug Carriers; Drug Delivery Systems; Liposomes; Male; Methotrexate; Microscopy, Confocal; Nanostructures; Particle Size; Phosphatidylcholines; Polysorbates; Rats, Sprague-Dawley; Skin; Skin Absorption; Sodium Cholate | 2016 |
The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Liberation; Drug Stability; Humans; Liposomes; Male; Methotrexate; Microdialysis; Particle Size; Phosphatidylcholines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface Properties; Tandem Mass Spectrometry | 2017 |
Novel theranostic zinc phthalocyanine-phospholipid complex self-assembled nanoparticles for imaging-guided targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake.
Topics: Animals; Drug Delivery Systems; Endocytosis; Female; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; Indoles; Injections, Subcutaneous; Isoindoles; Mammary Neoplasms, Animal; MCF-7 Cells; Methotrexate; Mice; Mice, Nude; Nanoparticles; Optical Imaging; Organometallic Compounds; Particle Size; Phosphatidylcholines; Phosphatidylethanolamines; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Reactive Oxygen Species; Theranostic Nanomedicine; Zinc Compounds | 2018 |
Enhanced Percutaneous Delivery of Methotrexate Using Micelles Prepared with Novel Cationic Amphipathic Material.
Topics: Administration, Cutaneous; Animals; Cations; Cattle; Drug Carriers; Drug Delivery Systems; Humans; Methotrexate; Mice; Micelles; Osmolar Concentration; Particle Size; Phosphatidylcholines; Proton Magnetic Resonance Spectroscopy; Serum Albumin, Bovine; Skin; Static Electricity | 2020 |
Drug Encapsulated Lipid-Polymeric Nanohybrid as a Chemo-therapeutic Platform of Cancer.
Topics: Humans; Methotrexate; Neoplasms; Pharmaceutical Preparations; Phosphatidylcholines; Polymers; Reactive Oxygen Species | 2023 |