phosphatidylcholines has been researched along with indomethacin in 66 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 29,527 | 1,838 | 3,396 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (36.36) | 18.7374 |
| 1990's | 18 (27.27) | 18.2507 |
| 2000's | 17 (25.76) | 29.6817 |
| 2010's | 6 (9.09) | 24.3611 |
| 2020's | 1 (1.52) | 2.80 |
| Authors | Studies |
|---|---|
| Clements, JA; Oyarzun, MJ | 1 |
| Champion, S; Haye, B; Jacquemin, C | 1 |
| Shier, WT | 1 |
| Brotzu, G; Dazzi, E; Pinna, M; Savona, G; Spada, MC | 1 |
| Ballejo, G; Bustos, R; Giussi, G; Isa, JC; Rosas, R | 1 |
| Blackwell, GJ; Duncombe, WG; Flower, RJ; Parsons, MF; Vane, JR | 1 |
| Prottey, C | 1 |
| Breitbart, H; Grossman, S; Lax, Y; Magid, N; Rubinstein, S | 1 |
| England, DW; Hoover, EL; Jaffe, BM; Webb, H | 1 |
| Bonne, C; Coquelet, C; Latour, E; Tissié, G; Trong, HN | 1 |
| Bing, RJ; Menon, NK; Pataricza, J; Zehetgruber, M | 1 |
| Furuya, A; Kawashima, Y; Nakajima, T; Ozawa, Y; Takashima, Y | 1 |
| Agnoli, GC; Andreone, P; Cacciari, M; Garutti, C; Ikonomu, E | 3 |
| Fujii, M; Matsumoto, M; Mori, T; Sawada, Y; Terai, H | 1 |
| Dimitrova, D; Ivancheva, E; Liochev, S; Russanov, E | 1 |
| Natsuki, R; Takabatake, E | 2 |
| Turinsky, J | 1 |
| Bakouche, Q; David, F; Gerlier, D | 1 |
| Gilfillan, AM; Rooney, SA | 1 |
| Fleming, R; Hagga, M | 1 |
| Lowenstein, LM; Smith, PD; Toback, FG | 1 |
| Caltabiano, M; Gazza, F; Mansani, FE | 1 |
| Ballard, PL; Campos, G; Clements, JA; Kitterman, JA; Lee, CH; Liggins, GC | 1 |
| Barker, E; Brendel, K; Chvapil, M; Eskelson, CD; LaFranconi, M; Solomon, S; Vostal, JJ | 1 |
| Gerrard, JM; Graff, G | 1 |
| Argunova, GA; Kashuba, EA; Kniazeva, EF; Orlov, MD; Tiumentseva, TS | 1 |
| Arias-Díaz, J; Balibrea, JL; García, C; Vara, E | 1 |
| Fernández-Tomé, MC; Sterin-Speziale, NB | 1 |
| Domingo, A; Guarner, F; Lugea, A; Malagelada, JR; Mourelle, M; Salas, A | 1 |
| Aldini, G; Carini, M; Macciocchi, A; Maffei Facino, R; Saibene, L | 1 |
| Beinborn, M; Bernhard, W; Linck, M; Schünemann, P; Sewing, KF | 1 |
| Adlercreutz, P; Ar'Rajab, A; Axelson, J; Bengmark, S; Dunjić, BS; Larsson, K; Svensson, I | 1 |
| Ar'Rajab, A; Axelson, J; Bengmark, S; Dunjic, BS; Larsson, K | 1 |
| Pyne, NJ; Pyne, S | 1 |
| Kato, K; Kozawa, O; Oiso, Y; Suzuki, A | 1 |
| Bernhard, W; Piller, M; Schulte, H; Sewing, KF | 1 |
| Csaba, G; Kovács, P | 1 |
| Qin, J; Sun, H; Torday, JS | 1 |
| Trotta, M | 1 |
| Chary, MG; Diwan, PV; Srinath, P; Vyas, SP | 1 |
| Barrios, JM; Lichtenberger, LM | 1 |
| Bevers, EM; Comfurius, P; Dekkers, DW; van Gool, RG; Zwaal, RF | 1 |
| Calder, PC; Cavaglieri, CR; Curi, R; Nishiyama, A | 1 |
| Blank, MA; Gibson, GW; Lichtenberger, LM; Romero, JJ | 1 |
| Chaimovich, H; Cuccovia, IM; Lima, JL; Matos, C; Reis, S | 1 |
| de Castro, B; Gameiro, P; Lima, JL; Matos, C; Reis, S | 1 |
| Fujii, M; Matsumoto, M; Shiozawa, K; Watanabe, Y | 1 |
| Eriksson, E; Hellstrand, M; Nilsson, CL | 1 |
| Bastos, M; Lima, JL; Lopes, A; Matos, C; Reis, S | 1 |
| Akkermans, LM; Kroese, AB; Petruzzelli, M; van Dijk, JE; van Erpecum, KJ; Venneman, NG; Verheem, A | 1 |
| Angel, I; Dahan, A; Duvdevani, R; Dvir, E; Friedman, JE; Hoffman, A; Koh, JY; Kozak, A; Lee, JY; Raz, S; Rosenberg, G; Shapiro, I; Younis, F | 1 |
| Dahan, A; Duvdevani, R; Dvir, E; Elmann, A; Hoffman, A | 1 |
| Ackerstaff, E; Artemov, D; Bhujwalla, ZM; Gimi, B | 1 |
| Assreuy, J; Charão, CT; Fernandes, D; Ramos, GC; Souza, DG; Teixeira, MM | 1 |
| Dahan, A; Duvdevani, R; Dvir, E; Elman, A; Friedman, JE; Hoffman, A; Shapiro, I; Simmons, D | 1 |
| Dial, EJ; Lichtenberger, L; Romero, JJ | 1 |
| Hancock, JF; Lichtenberger, LM; Plowman, SJ; Zhou, Y | 1 |
| Dial, EJ; Graham, DY; Lichtenberger, LM; Lim, YJ; Phan, TM | 1 |
| Gorfe, AA; Prakash, P | 1 |
| Dawson, PA; Dial, EJ; Lichtenberger, LM | 1 |
| Bozelli, JC; Cuccovia, IM; Grahl, D; Kamma-Lorger, CS; Nunes, C; Pereira-Leite, C; Reis, S; Schreier, S | 1 |
| Barba, AA; Bertoncin, P; Bochicchio, S; Dalmoro, A; Lamberti, G; Moustafine, RI; Nasibullin, SF | 1 |
| He, L; Huang, J; Mao, Y; Peng, R; Wang, C; Wang, L; Wei, W; Wen, Y; Xia, T; Yang, J; Zhao, L | 1 |
1 review(s) available for phosphatidylcholines and indomethacin
| Article | Year |
|---|---|
DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Drug Combinations; Group II Phospholipases A2; Humans; Indomethacin; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Rats | 2007 |
1 trial(s) available for phosphatidylcholines and indomethacin
| Article | Year |
|---|---|
[Clinico-pathogenetic substantiation of comprehensive therapy of Klebsiella infection with the syndrome of water diarrhea in infants].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane; Diarrhea, Infantile; Drug Therapy, Combination; Humans; Indomethacin; Infant, Newborn; Klebsiella Infections; Organophosphorus Compounds; Phosphatidylcholines; Risk Factors; Syndrome | 1994 |
64 other study(ies) available for phosphatidylcholines and indomethacin
| Article | Year |
|---|---|
Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arachidonic Acids; Cyclooxygenase Inhibitors; Indomethacin; Isoproterenol; Male; Meclofenamic Acid; Phenoxybenzamine; Phosphatidylcholines; Propranolol; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins H; Pulmonary Alveoli; Pulmonary Surfactants; Rabbits; Respiration; Sotalol; Terbutaline | 1978 |
Stimulation by TSH of prostaglandin synthesis in pig thyroid.
Topics: Animals; Arachidonic Acids; Aspirin; Bucladesine; Cyclic AMP; Enzyme Activation; Indomethacin; Lipase; Phosphatidylcholines; Phosphatidylinositols; Phospholipases; Phospholipids; Prostaglandins; Swine; Thyroid Gland; Thyrotropin; Triglycerides | 1976 |
Inhibition of acyl coenzyme A:lysolecithin acyltransferases by local anesthetics, detergents and inhibitors of cyclic nucleotide phosphodiesterases.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyltransferases; Anesthetics, Local; Animals; Aspirin; Cell Line; Detergents; Gastric Mucosa; Indomethacin; Liver; Mice; Myocardium; Phosphatidylcholines; Phosphodiesterase Inhibitors; Rabbits; Rats | 1977 |
Modification of surfactants in rat in septic shock.
Topics: Animals; Aprotinin; Fatty Acids; Hydrocortisone; Indomethacin; Lipids; Phosphatidylcholines; Pulmonary Surfactants; Rats; Shock, Septic | 1979 |
Inhibition of fetal lung maturation by indomethacin in pregnant rabbits.
Topics: Animals; Female; Fetal Blood; Fetus; Gestational Age; Hydrocortisone; Indomethacin; Lung; Maternal-Fetal Exchange; Phosphatidylcholines; Pregnancy; Rabbits | 1978 |
The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs.
Topics: Animals; Arachidonic Acids; Blood Platelets; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Chromatography, Gas; Collagen; Fatty Acids; Hydrolysis; In Vitro Techniques; Indomethacin; Lipids; Male; Phosphatidylcholines; Phospholipases; Phospholipids; Phosphorus; Platelet Aggregation; Quinacrine; Rabbits; Thrombin | 1977 |
Investigation of functions of essential fatty acids in the skin.
Topics: Animals; Arachidonic Acids; Fatty Acids, Essential; Hypophysectomy; Indomethacin; Linoleic Acids; Phosphatidylcholines; Prostaglandins; Prostaglandins E; Rats; Skin; Skin Physiological Phenomena; Time Factors; Water Loss, Insensible | 1977 |
Role of lipoxygenase in the mechanism of acrosome reaction in mammalian spermatozoa.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acrosome; Animals; Arachidonate 15-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Cyclooxygenase Inhibitors; Hydroxyeicosatetraenoic Acids; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Phosphatidylcholines; Spermatozoa | 1990 |
Synthesis of prostaglandins I2 and E2 by the canine gallbladder in vitro: studies using a new incubation chamber.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Depression, Chemical; Dinoprostone; Dogs; Epoprostenol; Female; Gallbladder; In Vitro Techniques; Incubators; Indomethacin; Male; Mucous Membrane; Phosphatidylcholines; Serous Membrane; Sex Factors; Stimulation, Chemical | 1990 |
Free radical scavenging capacity and anti-inflammatory activity of CBS-113 A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Free Radical Scavengers; Free Radicals; In Vitro Techniques; Indomethacin; Iron; Liposomes; Male; Oxygen Consumption; Peroxides; Phosphatidylcholines; Rabbits; Superoxides; Thiazoles; Uveitis; Xanthine Oxidase | 1990 |
A model to study physiological activation of phospholipase A2 and vasorelaxation by lysophosphatidylcholine.
Topics: Acetylcholine; Animals; Bradykinin; Calcimycin; Carbon Radioisotopes; Cattle; Endothelium; Enzyme Activation; Histamine; Indomethacin; Lipid Metabolism; Lysophosphatidylcholines; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Pulmonary Artery; Thrombin | 1990 |
Study on absorption of indomethacin from sustained-release suppositories containing hydrogenated soybean lecithin in rabbits.
Topics: Animals; Delayed-Action Preparations; Excipients; Glycine max; Indomethacin; Intestinal Absorption; Male; Phosphatidylcholines; Rabbits; Suppositories | 1989 |
Effects of indomethacin and polyunsaturated phosphatidylcholine on short-term control of renal water excretion.
Topics: Adult; Diuresis; Electrolytes; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney; Lypressin; Phosphatidylcholines; Prostaglandins E | 1985 |
The properties of solid dispersions of indomethacin, ketoprofen and flurbiprofen in phosphatidylcholine.
Topics: Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Flurbiprofen; Indomethacin; Ketoprofen; Phenylpropionates; Phosphatidylcholines; Powders; Propionates | 1988 |
Phosphatidylcholine peroxidation induced by Cu(II) and some Cu(II) complexes.
Topics: Ascorbic Acid; Aspirin; Cimetidine; Copper; Glycine; Indomethacin; Lipid Peroxides; NAD; Oxidation-Reduction; Phosphatidylcholines | 1988 |
[Effect of lecithin on percutaneous absorption of drugs. I. Absorption and excretion of indomethacin gel-ointment through rat back skin].
Topics: Animals; Gels; Indomethacin; Male; Ointments; Phosphatidylcholines; Rats; Rats, Inbred Strains; Skin; Skin Absorption | 1987 |
[Effect of lecithin on percutaneous absorption of drugs. II. Mechanism of enhancing effect of lecithin on the percutaneous absorption of indomethacin gel-ointment].
Topics: Adjuvants, Pharmaceutic; Animals; Gels; Indomethacin; Male; Ointments; Phosphatidylcholines; Rats; Rats, Inbred Strains; Skin; Skin Absorption; Stimulation, Chemical | 1987 |
Phospholipids, prostaglandin E2, and proteolysis in denervated muscle.
Topics: Animals; Aspirin; Cardiolipins; Cycloheximide; Dinoprostone; Indomethacin; Lysophosphatidylcholines; Male; Muscle Denervation; Muscle Proteins; Muscles; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Prostaglandins E; Rats; Rats, Inbred Strains; Sphingomyelins; Tyrosine | 1986 |
Impairment of immunogenicity by antigen presentation in liposomes made from dimyristoylphosphatidylethanolamine linked to the secretion of prostaglandins by macrophages.
Topics: Animals; Antibody Formation; Antigen-Presenting Cells; Antigens, Neoplasm; Immunization, Passive; Immunologic Memory; Indomethacin; Liposomes; Phosphatidylcholines; Phosphatidylethanolamines; Prostaglandins; Rats; Solubility | 1987 |
Arachidonic acid metabolites stimulate phosphatidylcholine secretion in primary cultures of type II pneumocytes.
Topics: Animals; Arachidonic Acids; Catechols; Cells, Cultured; Dose-Response Relationship, Drug; Flufenamic Acid; Ibuprofen; In Vitro Techniques; Indomethacin; Lung; Male; Masoprocol; Naproxen; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1985 |
Proceedings: The binding of 8-anilino-1-naphthalene sulphonate (ANS) to phosphatidylcholine and its displacement by indomethacin.
Topics: Anilino Naphthalenesulfonates; Binding Sites; Indomethacin; Mathematics; Phosphatidylcholines | 1973 |
Phospholipid metabolism in the initiation of renal compensatory growth after acute reduction of renal mass.
Topics: Animals; Carbon Radioisotopes; Cell Membrane; Choline; Indomethacin; Kidney; Kidney Cortex; Lysophosphatidylcholines; Male; Mice; Nephrectomy; Phosphatidylcholines; Phospholipids; Rats; Sphingomyelins | 1974 |
[Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria].
Topics: Adult; Diuresis; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney Function Tests; Linoleic Acid; Linoleic Acids; Natriuresis; Phosphatidylcholines; Polyuria; Potassium; Prostaglandins E | 1984 |
[Relation between acute changes in diuresis and renal prostaglandins. II. Induced antidiuresis].
Topics: Creatinine; Diuresis; Humans; Indomethacin; Kidney Function Tests; Lypressin; Male; Natriuresis; Phosphatidylcholines; Potassium; Prostaglandins E; Time Factors | 1984 |
RDS prophylaxis in preterm labor: corticosteroids and beta-mimetics association-indications and limits.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Adrenal Cortex Hormones; Drug Therapy, Combination; Female; Humans; Indomethacin; Infant Mortality; Infant, Newborn; Obstetric Labor, Premature; Phosphatidylcholines; Pregnancy; Pregnancy Trimester, Third; Respiratory Distress Syndrome, Newborn; Scopolamine; Sympathomimetics | 1984 |
Inhibitors of prostaglandin synthesis, tracheal fluid, and surfactant in fetal lambs.
Topics: Animals; Body Fluids; Female; Hydrogen-Ion Concentration; Indomethacin; Lung; Oxygen; Phosphatidylcholines; Pregnancy; Prostaglandins; Pulmonary Surfactants; Sheep; Trachea | 1981 |
Some relationships between pulmonary prostaglandins and hepatocyte lecithin formation.
Topics: Acetates; Animals; Cholesterol; Fatty Acids, Nonesterified; In Vitro Techniques; Indomethacin; Liver; Lung; Phosphatidylcholines; Phosphatidylethanolamines; Prostaglandins; Rats; Triglycerides | 1981 |
1-arachidonyl-monoglyceride causes platelet aggregation: indirect evidence for an acylglycerol acylhydrolase involvement in the release of arachidonic acid for prostaglandin synthesis.
Topics: Arachidonic Acids; Aspirin; Blood Platelets; Glycerides; Humans; Indomethacin; Liposomes; Lysophospholipase; Phosphatidylcholines; Phospholipases; Platelet Aggregation; Prostaglandins | 1980 |
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins.
Topics: Adult; Age Factors; Arachidonic Acid; Humans; In Vitro Techniques; Indomethacin; Lung; Male; Middle Aged; Pentoxifylline; Phosphatidylcholines; Prostaglandins; Respiratory Distress Syndrome; Tumor Necrosis Factor-alpha | 1994 |
Short- and long-term treatment with indometacin causes renal phospholipid alteration: a possible explanation for indomethacin nephrotoxicity.
Topics: Animals; Indomethacin; Kidney; Kidney Medulla; Male; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Rats; Rats, Wistar; Sphingomyelins | 1994 |
Phosphatidylcholines as mediators of adaptive cytoprotection of the rat duodenum.
Topics: 16,16-Dimethylprostaglandin E2; Adaptation, Physiological; Animals; Detergents; Duodenum; Hydrochloric Acid; Indomethacin; Male; Mucus; Phosphatidylcholines; Phospholipids; Polidocanol; Polyethylene Glycols; Rats; Rats, Sprague-Dawley | 1994 |
Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indomethacin; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Sulfonamides | 1993 |
Phospholipid synthesis in isolated porcine gastric mucous cells.
Topics: Animals; Cell Separation; Choline; Ethanolamine; Ethanolamines; Gastric Mucosa; Indomethacin; Phosphatidylcholines; Phosphatidylethanolamines; Swine | 1994 |
Green banana protection of gastric mucosa against experimentally induced injuries in rats. A multicomponent mechanism?
Topics: Acute Disease; Animals; Chronic Disease; Ethanol; Fruit; Gastric Mucosa; Indomethacin; Male; Models, Biological; Pectins; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Suspensions | 1993 |
Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats.
Topics: Animals; Chronic Disease; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1993 |
Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle.
Topics: Animals; Bradykinin; Calcium; Cells, Cultured; Glycerophospholipids; GTP-Binding Proteins; Guinea Pigs; Indomethacin; Muscle, Smooth; Palmitates; Pertussis Toxin; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Trachea; Tritium; Virulence Factors, Bordetella | 1993 |
Protein kinase C activation inhibits stress-induced synthesis of heat shock protein 27 in osteoblast-like cells: function of arachidonic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Arsenites; Choline; Cyclic AMP; Enzyme Activation; Heat-Shock Proteins; Indomethacin; Inositol Phosphates; Masoprocol; Melitten; Mice; Osteoblasts; Phosphatidylcholines; Protein Kinase C; Stress, Physiological; Tetradecanoylphorbol Acetate | 1996 |
Synthesis and release of phosphatidylcholine by isolated porcine gastric mucous cells in primary culture.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Separation; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Gastric Mucosa; Indomethacin; Phosphatidylcholines; Swine; Tetradecanoylphorbol Acetate | 1996 |
Indomethacin alters phospholipid and arachidonate metabolism in Tetrahymena pyriformis.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Diglycerides; Indomethacin; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorus Radioisotopes; Signal Transduction; Tetrahymena pyriformis; Tritium | 1997 |
Prostaglandin E2 integrates the effects of fluid distension and glucocorticoid on lung maturation.
Topics: Animals; Bumetanide; Dexamethasone; Dinoprostone; Embryonic and Fetal Development; Fetus; Fibroblasts; Gestational Age; Indomethacin; Lung; Organ Culture Techniques; Phloretin; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Triglycerides; Triolein | 1998 |
Influence of phase transformation on indomethacin release from microemulsions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallization; Delayed-Action Preparations; Drug Delivery Systems; Emulsions; Ethanol; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Lysophosphatidylcholines; Myristates; Particle Size; Phosphatidylcholines; Solvents; Time Factors; Water | 1999 |
Long-circulating liposomes of indomethacin in arthritic rats--a biodisposition study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Indomethacin; Liposomes; Male; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Wistar; Tissue Distribution | 2000 |
Role of biliary phosphatidylcholine in bile acid protection and NSAID injury of the ileal mucosa in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Erythrocytes; Hemolysis; Ileal Diseases; Ileum; Indomethacin; Intestinal Mucosa; Male; Micelles; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 2000 |
Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminocaproates; Aminocaproic Acid; Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Cell Membrane; Erythrocytes; Fluorescent Dyes; Humans; Hydrolysis; Indomethacin; Lipid Bilayers; Microscopy, Electron; Multidrug Resistance-Associated Proteins; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Sphingomyelin Phosphodiesterase; Time Factors; Vasodilator Agents; Verapamil | 2000 |
Arachidonic acid-containing phosphatidylcholine inhibits lymphocyte proliferation and decreases interleukin-2 and interferon-gamma production from concanavalin A-stimulated rat lymphocytes.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Concanavalin A; Indomethacin; Interferon-gamma; Interleukin-2; Lipid Peroxidation; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; Male; Phosphatidylcholines; Rats; Rats, Wistar; Thymidine; Tritium; Vitamin E | 2000 |
Effect of bisphosphonates on surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Diphosphonates; Etidronic Acid; Gastric Mucosa; Indomethacin; Male; Pamidronate; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Risedronic Acid; Surface Properties | 2000 |
Effect of liposomes on the rate of alkaline hydrolysis of indomethacin and acemetacin.
Topics: Hydrogen-Ion Concentration; Hydrolysis; Indomethacin; Liposomes; Micelles; Phosphatidylcholines; Quaternary Ammonium Compounds | 2001 |
A fast and reliable spectroscopic method for the determination of membrane--water partition coefficients of organic compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Egg Yolk; Electrodes; Hydrogen-Ion Concentration; Indomethacin; Liposomes; Mathematics; Phosphatidylcholines; Spectrophotometry; Static Electricity; Water | 2001 |
Effect of phosphatidylcholine on skin permeation of indomethacin from gel prepared with liquid paraffin and hydrogenated phospholipid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Gels; Indomethacin; Male; Mineral Oil; Phosphatidylcholines; Phospholipids; Rats; Skin Absorption; Solubility | 2001 |
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase 2; Dinoprostone; Dopamine; Dopamine Antagonists; Drug Interactions; Enzyme Inhibitors; Gallic Acid; Indomethacin; Isoenzymes; Naphthalenes; Nitrobenzenes; Phosphatidylcholines; Prostaglandin-Endoperoxide Synthases; Pyrones; Quinacrine; Receptors, Dopamine D2; Salicylamides; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 2002 |
Interaction of antiinflammatory drugs with EPC liposomes: calorimetric study in a broad concentration range.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Calorimetry; Computer Simulation; Indomethacin; Lipid Bilayers; Liposomes; Macromolecular Substances; Models, Chemical; Molecular Conformation; Phase Transition; Phosphatidylcholines | 2004 |
Indomethacin disrupts the protective effect of phosphatidylcholine against bile salt-induced ileal mucosa injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cholagogues and Choleretics; Female; Humans; Ileum; Indomethacin; Intestinal Mucosa; L-Lactate Dehydrogenase; Permeability; Phosphatidylcholines; Rats; Rats, Wistar; Taurodeoxycholic Acid | 2006 |
A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar eff
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Area Under Curve; Brain; Brain Chemistry; Dinoprostone; Drug Combinations; Gastrointestinal Tract; Indomethacin; Kidney; Male; Mice; Mice, Transgenic; Peptide Fragments; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 2006 |
A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: in-vivo and in-vitro evaluation of an indomethacin-lecithin conjugate.
Topics: Administration, Oral; Animals; Biological Availability; Delayed-Action Preparations; Drug Evaluation, Preclinical; Indomethacin; Intestinal Mucosa; Intestines; Male; Phosphatidylcholines; Phospholipids; Prodrugs; Rats; Rats, Wistar | 2007 |
Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Indomethacin; Magnetic Resonance Spectroscopy; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Phosphatidylcholines; Prostaglandin-Endoperoxide Synthases; Triglycerides | 2007 |
Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carrageenan; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Indomethacin; Inflammation; Liposomes; Mice; Peroxisome Proliferator-Activated Receptors; Phosphatidylcholines; Phosphatidylserines | 2007 |
Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dinoprostone; Drug Administration Routes; Gastrointestinal Hemorrhage; Indomethacin; Models, Animal; Phosphatidylcholines; Radioimmunoassay; Rats; Stomach Ulcer | 2009 |
The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes.
Topics: 2-Naphthylamine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Membrane; Cholesterol; Cricetinae; Fluorescence Polarization; Fluorescent Dyes; Humans; Indomethacin; Laurates; Membranes, Artificial; Phosphatidylcholines; Signal Transduction | 2010 |
In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Cells, Cultured; Epithelial Cells; Gastrointestinal Hemorrhage; Indomethacin; Intestinal Mucosa; Intestine, Small; Lansoprazole; Male; Omeprazole; Phosphatidylcholines; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 2012 |
Phosphatidylcholine attenuates aggregation of nonsteroidal anti-inflammatory drugs with bile acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane; Cholic Acid; Computer Simulation; Hydrophobic and Hydrophilic Interactions; Indomethacin; Liposomes; Micelles; Models, Chemical; Phosphatidylcholines | 2013 |
In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Cell Membrane; Gastrointestinal Agents; Gastrointestinal Hemorrhage; Indomethacin; Mice; Organic Anion Transporters, Sodium-Dependent; Phosphatidylcholines; Symporters | 2015 |
Acemetacin-phosphatidylcholine interactions are determined by the drug ionization state.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Lipid Bilayers; Molecular Structure; Phase Transition; Phosphatidylcholines; Static Electricity; Temperature | 2018 |
Polymer-lipid hybrid nanoparticles as enhanced indomethacin delivery systems.
Topics: Adhesiveness; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Cholesterol; Drug Delivery Systems; Drug Liberation; Gastric Juice; Indomethacin; Intestinal Secretions; Liposomes; Microfluidics; Mucins; Nanoparticles; Phosphatidylcholines | 2018 |
Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model poorly soluble drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Delivery Systems; Excipients; Indomethacin; Male; Models, Chemical; Phosphatidylcholines; Povidone; Rats; Rats, Sprague-Dawley; Solubility; Viscosity | 2020 |