phosphatidylcholines has been researched along with ibuprofen in 27 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (ibuprofen) | Trials (ibuprofen) | Recent Studies (post-2010) (ibuprofen) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 10,245 | 1,781 | 4,267 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | ibuprofen (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 2.9 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 1.1 | |
| Albumin | Bos taurus (cattle) | 3 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 4.0919 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 0.22 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 1.6273 | |
| Caspase-1 | Homo sapiens (human) | 7.2667 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 1.1 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 3.0687 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 1.3 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 10 | |
| Caspase-3 | Homo sapiens (human) | 7.2667 | |
| Caspase-4 | Homo sapiens (human) | 7.2667 | |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | 1.1 | |
| Caspase-5 | Homo sapiens (human) | 7.2667 | |
| Caspase-9 | Homo sapiens (human) | 7.2667 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 1.1375 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 2.9 | |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | 5 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.54 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 8 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 1.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Gilfillan, AM; Rooney, SA | 1 |
| Müller-Goymann, CC; Schröder, K; Stoye, I | 1 |
| Kilpeläinen, I; Paavola, A; Rosenberg, P; Yliruusi, J | 1 |
| Ashraf, AQ; Behbod, F; Darling, R; de Ruijter, WM; Lichtenberger, LM; Romero, JJ; Sanduja, SK | 1 |
| Gaede, HC; Gawrisch, K | 2 |
| Bai, G; Liu, M; Yang, Y; Ye, C; Zhang, X | 1 |
| Holmsen, H; Lygre, H; Moe, G | 1 |
| Coombes, AG; Fitzgerald, M; Mohammed, AR; Perrie, Y; Weston, N | 1 |
| Dial, EJ; Doyen, JR; Lichtenberger, LM | 1 |
| Coombes, AG; Mohammed, AR; Perrie, Y | 1 |
| Lan, W; Liu, M; Ye, C; Zhou, Z; Zhu, H | 1 |
| Kulmacz, RJ; Lichtenberger, LM; Rand Doyen, J; Yucer, N | 1 |
| Albertine, KH; Chang, LY; Clyman, RI; Dahl, MJ; Giavedoni, L; Ikegami, M; McCurnin, D; Petershack, J; Seidner, S; Waleh, N; Wang, ZM; Yoder, B | 1 |
| Anand, BS; Lanza, FL; Lichtenberger, LM; Marathi, UK | 1 |
| Anzenbacher, P; Berka, K; Hendrychová, T; Otyepka, M | 1 |
| Constantinides, PP; Mattheolabakis, G; Nie, T; Rigas, B | 1 |
| Brausch, JF; Hussain, MD; Saxena, V; Talukder, RM | 1 |
| Boggara, MB; Dial, EJ; Doyen, JR; Gorenstein, DG; Jayaraman, V; Krishnamoorti, R; Lichtenberger, LM; O'Neil, RG; Volk, DE; Zhou, Y | 1 |
| Berka, K; Otyepka, M; Paloncýová, M | 1 |
| Bajpai, M; Gaur, PK; Mishra, S; Verma, A | 1 |
| Fischer, SF; Frielinghaus, H; Hertrich, S; Holderer, O; Ivanova, O; Jaksch, S; Koutsioubas, A; Lipfert, F; Mattauch, S; Nickel, B | 1 |
| Angelini, G; Boncompagni, S; Campestre, C; Gasbarri, C | 1 |
| Grudniewska, A; Kiełbowicz, G; Kocbach, B; Kłobucki, M; Maciejewska, G; Ugorski, M; Urbaniak, A; Wawrzeńczyk, C | 1 |
| Borrell, JH; Botet-Carreras, A; Domènech, Ò; Teresa Montero, M; Vázquez-González, ML | 1 |
| Huster, D; Kremkow, J; Luck, M; Müller, P; Scheidt, HA | 1 |
| Braziel, S; Gayapa, A; Giancaspro, J; Krmic, M; Lee, S; Miller, E; Morales, M; Rosario, J; Scollan, P; Wood, M | 1 |
1 trial(s) available for phosphatidylcholines and ibuprofen
| Article | Year |
|---|---|
Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Phosphatidylcholines; Stomach Ulcer; Treatment Outcome | 2008 |
26 other study(ies) available for phosphatidylcholines and ibuprofen
| Article | Year |
|---|---|
Arachidonic acid metabolites stimulate phosphatidylcholine secretion in primary cultures of type II pneumocytes.
Topics: Animals; Arachidonic Acids; Catechols; Cells, Cultured; Dose-Response Relationship, Drug; Flufenamic Acid; Ibuprofen; In Vitro Techniques; Indomethacin; Lung; Male; Masoprocol; Naproxen; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1985 |
Transformation of a liposomal dispersion containing ibuprofen lysinate and phospholipids into mixed micelles - physico-chemical characterization and influence on drug permeation through excised human stratum corneum.
Topics: Cell Membrane Permeability; Drug Carriers; Epidermis; Humans; Ibuprofen; In Vitro Techniques; Liposomes; Lysine; Micelles; Microscopy, Electron; Phosphatidylcholines; Phospholipids | 1998 |
Controlled release injectable liposomal gel of ibuprofen for epidural analgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Stability; Dura Mater; Gels; Ibuprofen; In Vitro Techniques; Liposomes; Magnetic Resonance Spectroscopy; Permeability; Phosphatidylcholines; Poloxamer; Solubility; Swine | 2000 |
Phosphatidylcholine association increases the anti-inflammatory and analgesic activity of ibuprofen in acute and chronic rodent models of joint inflammation: relationship to alterations in bioavailability and cyclooxygenase-inhibitory potency.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; Chemistry, Pharmaceutical; Cyclooxygenase Inhibitors; Drug Combinations; Drug Synergism; Ibuprofen; Male; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 2001 |
Lateral diffusion rates of lipid, water, and a hydrophobic drug in a multilamellar liposome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biophysical Phenomena; Biophysics; Calibration; Diffusion; Ibuprofen; Lipid Bilayers; Lipids; Liposomes; Magnetic Resonance Spectroscopy; Models, Chemical; Phosphatidylcholines; Temperature; Time Factors; Water | 2003 |
1H NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma.
Topics: Binding Sites; Humans; Ibuprofen; Lipoproteins; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylcholines; Protein Binding; Protein Conformation; Protons; Sphingomyelins | 2004 |
Multi-dimensional pulsed field gradient magic angle spinning NMR experiments on membranes.
Topics: Calibration; Deuterium Oxide; Ibuprofen; Liposomes; Magnetic Resonance Spectroscopy; Membranes, Artificial; Phosphatidylcholines; Thermodynamics | 2004 |
Interaction of ibuprofen with eukaryotic membrane lipids.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Crystallization; Dose-Response Relationship, Drug; Ethanolamines; Gels; Glycerophospholipids; Humans; Ibuprofen; Liposomes; Membrane Lipids; Models, Chemical; Phase Transition; Phosphatidylcholines; Phosphatidylserines; Solutions; Transition Temperature | 2003 |
Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability.
Topics: Chemistry, Pharmaceutical; Cholesterol; Drug Carriers; Drug Stability; Egg Yolk; Ibuprofen; Liposomes; Membrane Lipids; Microscopy, Electron, Scanning; Organophosphates; Phosphatidylcholines; Solubility; Water | 2004 |
Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Ibuprofen; Necrosis; Nucleic Acid Synthesis Inhibitors; Phosphatidylcholines | 2006 |
Amino acids as cryoprotectants for liposomal delivery systems.
Topics: Amino Acids; Arginine; Chemistry, Pharmaceutical; Cholesterol; Cryoprotective Agents; Drug Carriers; Drug Compounding; Freeze Drying; Histidine; Ibuprofen; Lipids; Liposomes; Lysine; Particle Size; Phosphatidylcholines; Solubility; Technology, Pharmaceutical; Temperature; Time Factors; Trehalose; Viscosity; Water | 2007 |
1H NMR investigation on interaction between ibuprofen and lipoproteins.
Topics: Antioxidants; Binding Sites; Humans; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Phosphatidylcholines; Solubility; Sphingomyelins | 2007 |
Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics.
Topics: Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Hydrogen-Ion Concentration; Ibuprofen; Kinetics; Lipid Bilayers; Liposomes; Membrane Fluidity; Micelles; Oleic Acid; Phosphatidylcholines; Phosphatidylserines; Phospholipids | 2008 |
Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Ductus Arteriosus, Patent; Epithelial Sodium Channels; Extravascular Lung Water; Female; Fetal Organ Maturity; Hemodynamics; Ibuprofen; Inflammation Mediators; Lung; Male; Papio papio; Phosphatidylcholines; Pulmonary Surfactant-Associated Proteins; Respiration | 2008 |
Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site.
Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP2C9; Humans; Ibuprofen; Membranes, Artificial; Models, Molecular; Molecular Dynamics Simulation; Phosphatidylcholines; Surface Properties | 2011 |
Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): preparation, characterization, and in vitro/in vivo evaluation.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Colonic Neoplasms; Cryoprotective Agents; Dose-Response Relationship, Drug; Drug Compounding; Drug Stability; Female; Freeze Drying; Humans; Ibuprofen; Inhibitory Concentration 50; Injections, Intraperitoneal; Kinetics; Lipids; Liposomes; Mice; Mice, SCID; Organophosphates; Particle Size; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Solubility; Surface Properties; Technology, Pharmaceutical; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Ibuprofen-phospholipid solid dispersions: improved dissolution and gastric tolerance.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chloroform; Crystallization; Crystallography, X-Ray; Cytoprotection; Dimyristoylphosphatidylcholine; Drug Carriers; Drug Compounding; Ethanol; Gastric Mucosa; Ibuprofen; Male; Microscopy, Electron, Scanning; Phosphatidylcholines; Phosphatidylglycerols; Phospholipids; Powder Diffraction; Rats; Rats, Sprague-Dawley; Solubility; Solvents; Stomach Ulcer; Technology, Pharmaceutical; Time Factors | 2012 |
Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Cell Membrane Permeability; Fluorescent Dyes; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Naproxen; Phosphatidylcholines; Pyridinium Compounds; Spectroscopy, Fourier Transform Infrared; Surface Plasmon Resonance | 2012 |
Molecular insight into affinities of drugs and their metabolites to lipid bilayers.
Topics: Caffeine; Cell Membrane; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Ibuprofen; Lipid Bilayers; Molecular Dynamics Simulation; Pharmaceutical Preparations; Phosphatidylcholines; Phosphatidylglycerols; Thermodynamics; Xenobiotics | 2013 |
Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity.
Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Carrageenan; Cholesterol; Delayed-Action Preparations; Diffusion Chambers, Culture; Drug Compounding; Drug Liberation; Edema; Gels; Hindlimb; Humans; Ibuprofen; Liposomes; Organophosphates; Permeability; Phosphatidylcholines; Rats; Rats, Wistar; Skin | 2016 |
Influence of ibuprofen on phospholipid membranes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Elasticity; Ibuprofen; Lipid Bilayers; Neutron Diffraction; Phosphatidylcholines; Scattering, Small Angle; Spectrum Analysis | 2015 |
Liposomes entrapping β-cyclodextrin/ibuprofen inclusion complex: Role of the host and the guest on the bilayer integrity and microviscosity.
Topics: beta-Cyclodextrins; Ibuprofen; Lipid Bilayers; Liposomes; Phosphatidylcholines; Viscosity | 2017 |
Syntheses and cytotoxicity of phosphatidylcholines containing ibuprofen or naproxen moieties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Line; Cytotoxins; Epithelial Cells; Humans; Ibuprofen; Lysophosphatidylcholines; Naproxen; Palmitic Acid; Phosphatidylcholines; Phospholipids; Swine | 2019 |
Planar lipid bilayers formed from thermodynamically-optimized liposomes as new featured carriers for drug delivery systems through human skin.
Topics: Administration, Cutaneous; Ceramides; Cholesterol; Drug Delivery Systems; Humans; Hyaluronic Acid; Ibuprofen; Lipid Bilayers; Liposomes; Phosphatidylcholines; Polysorbates; Skin; Skin Absorption; Thermodynamics | 2019 |
Membrane Interaction of Ibuprofen with Cholesterol-Containing Lipid Membranes.
Topics: Cholesterol; Ibuprofen; Lipid Bilayers; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Unilamellar Liposomes | 2020 |
Ibuprofen and the Phosphatidylcholine Bilayer: Membrane Water Permeability in the Presence and Absence of Cholesterol.
Topics: Cholesterol; Ibuprofen; Lipid Bilayers; Permeability; Phosphatidylcholines; Water | 2021 |