phosphatidylcholines has been researched along with fluorouracil in 16 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (fluorouracil) | Trials (fluorouracil) | Recent Studies (post-2010) (fluorouracil) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 45,562 | 9,307 | 14,663 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | fluorouracil (IC50) |
|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | 0.32 | |
| Thymidylate synthase | Mus musculus (house mouse) | 1.58 | |
| Aromatase | Homo sapiens (human) | 0.63 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, PA; Simmons, SP | 1 |
| Ohanian, SH; Schlager, SI | 1 |
| Chantres, JR; Elorza, B; Elorza, MA; Frutos, G | 1 |
| Givens, M; He, JL; Hsia, SL; Romagosa, R; Saap, L; Salvarrey, A; Taylor, JR | 1 |
| Fittkau, M; Gerlach, R; Schmoll, HJ | 1 |
| Brandl, M; Burger, AM; Fiebig, HH; Kaiser, N; Kimpfler, A; Massing, U; Schubert, R | 1 |
| Gupta, Y; Jain, A; Jain, P; Jain, SK | 1 |
| Bally, MB; Edwards, K; Hare, JI; Kapanen, AI; Karlsson, G; Ramsay, E; Thomas, AM | 1 |
| Banerjee, S; Guha, SK; Pal, TK; Sen, K | 1 |
| Jain, S; Puri, R | 1 |
| Anantha, M; Bally, MB; Harasym, N; Manisali, I; Masin, D; Osooly, M; Ostlund, C; Santos, ND; Strutt, D; Sutherland, BW; Waterhouse, DN; Webb, MS; Wehbe, M | 1 |
| Baldwin, WS; Gerard, PD; Reardon, DC; Sengupta, N | 1 |
| Alonso, SDV; Calienni, MN; Fresta, M; Montanari, J; Paolino, D; Prieto, MJ; Tekinay, AB; Temprana, CF | 1 |
| Aires, V; Cotte, AK; de Barros, JP; Delmas, D; Derangère, V; Fredon, M; Ghiringhelli, F; Hillon, P; Humblin, E; Limagne, E; Scagliarini, A; Thibaudin, M | 1 |
| Farzad, F; Pakdel, M; Pasban, S; Raissi, H | 1 |
| Druzhkova, I; Gubina, M; Gulin, A; Ignatova, N; Khlynova, A; Kuimova, MK; Shimolina, L; Shirmanova, M; Zagaynova, E | 1 |
1 trial(s) available for phosphatidylcholines and fluorouracil
| Article | Year |
|---|---|
A pilot study to evaluate the treatment of basal cell carcinoma with 5-fluorouracil using phosphatidyl choline as a transepidermal carrier.
Topics: Administration, Topical; Carcinoma, Basal Cell; Double-Blind Method; Drug Carriers; Fluorouracil; Humans; Ointments; Phosphatidylcholines; Pilot Projects; Skin Neoplasms | 2000 |
15 other study(ies) available for phosphatidylcholines and fluorouracil
| Article | Year |
|---|---|
Liposomal entrapment of floxuridine.
Topics: Chemistry, Pharmaceutical; Cholesterol; Diffusion; Eggs; Floxuridine; Fluorouracil; Liposomes; Phosphatidylcholines; Sphingomyelins; Sucrose; Time Factors | 1977 |
Tumor cell lipid composition and sensitivity to humoral immune killing. I. Modification of cellular lipid and fatty acid content by metabolic inhibitors and hormones.
Topics: Animals; Carcinoma, Hepatocellular; Cardiolipins; Cattle; Cholesterol; Cytotoxicity, Immunologic; Dactinomycin; Doxorubicin; Fatty Acids; Fluorouracil; Guinea Pigs; Insulin; Lipids; Liver Neoplasms; Lysophosphatidylcholines; Phosphatidylcholines | 1980 |
Characterization of 5-fluorouracil loaded liposomes prepared by reverse-phase evaporation or freezing-thawing extrusion methods: study of drug release.
Topics: Animals; Cattle; Drug Carriers; Fluorouracil; Freezing; Kinetics; Liposomes; Phosphatidylcholines; Sphingomyelins | 1993 |
Phosphatidylcholine does not protect rats against 5-fluorouracil/folinic acid-induced damage of the intestinal luminal mucosa.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Female; Fluorouracil; Infusions, Intravenous; Intestinal Mucosa; Leucovorin; Phosphatidylcholines; Rats; Rats, Wistar | 2002 |
5-Fluorouracil in vesicular phospholipid gels for anticancer treatment: entrapment and release properties.
Topics: Antimetabolites, Antineoplastic; Cholesterol; Chromatography, High Pressure Liquid; Cryoelectron Microscopy; Drug Compounding; Fluorouracil; Gels; Hydrogen-Ion Concentration; Infusion Pumps, Implantable; Liposomes; Particle Size; Phosphatidylcholines; Solubility; Time Factors | 2003 |
Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Cholesterol; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Inhibitory Concentration 50; Liposomes; Melanoma, Experimental; Mice; Neoplasm Transplantation; Particle Size; Phosphatidylcholines; Polyethylene Glycols | 2007 |
Development of a liposomal nanoparticle formulation of 5-fluorouracil for parenteral administration: formulation design, pharmacokinetics and efficacy.
Topics: Animals; Biological Availability; Body Weight; Cell Survival; Cholesterol; DNA-Binding Proteins; Drug Delivery Systems; Drug Stability; Female; Fluorouracil; HT29 Cells; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Liposomes; Mice; Mice, Inbred BALB C; Mice, Knockout; Microscopy, Electron, Transmission; Neoplasms; Organometallic Compounds; Particle Size; Phosphatidylcholines; Polyethyleneimine; Static Electricity; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cytosol; Erythrocytes; Fluorouracil; Hemolysis; HT29 Cells; Humans; Hydrogen-Ion Concentration; Liposomes; Male; Maleates; Mice; NIH 3T3 Cells; Phosphatidylcholines; Polystyrenes | 2012 |
Ethogel topical formulation for increasing the local bioavailability of 5-fluorouracil: a mechanistic study.
Topics: Acrylates; Administration, Cutaneous; Animals; Antimetabolites, Antineoplastic; Biological Availability; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diffusion Chambers, Culture; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Screening Assays, Antitumor; Elasticity; Fluorouracil; Gels; Glycine max; Humans; In Vitro Techniques; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Permeability; Phosphatidylcholines; Rats; Skin; Skin Absorption; Skin Irritancy Tests; Spectroscopy, Fourier Transform Infrared; Tissue Distribution; Viscosity | 2012 |
Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cholesterol; Colon; Diarrhea; Disease Models, Animal; Drug Therapy, Combination; Female; Fluorouracil; Intestine, Small; Irinotecan; Liposomes; Nanoparticles; Phosphatidylcholines; Rats, Sprague-Dawley | 2014 |
Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants.
Topics: Animals; Atrazine; Daphnia; Dietary Fats; Fatty Acids, Unsaturated; Fertility; Fluorouracil; Gene Expression Regulation; Lipid Metabolism; Phosphatidylcholines; Sphingomyelins; Triclosan; Water Pollutants, Chemical | 2017 |
Nano-formulation for topical treatment of precancerous lesions: skin penetration, in vitro, and in vivo toxicological evaluation.
Topics: Administration, Cutaneous; Administration, Topical; Adult; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Drug Compounding; Drug Liberation; Female; Fluorouracil; Heart Rate; Humans; Keratinocytes; Larva; Liposomes; Melanoma; Motor Activity; Nanoparticles; Phosphatidylcholines; Skin; Skin Absorption; Sodium Cholate; Zebrafish | 2018 |
Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Caspases; CD8-Positive T-Lymphocytes; Cell Death; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Homeostasis; Humans; Lipids; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Organoplatinum Compounds; Oxaliplatin; Phenotype; Phosphatidylcholines; Triglycerides | 2018 |
Enhance the efficiency of 5-fluorouracil targeted delivery by using a prodrug approach as a novel strategy for prolonged circulation time and improved permeation.
Topics: Antineoplastic Agents; Delayed-Action Preparations; Fluorouracil; Lipid Bilayers; Maleimides; Molecular Dynamics Simulation; Nanotubes, Carbon; Permeability; Phosphatidylcholines; Prodrugs | 2019 |
Development of resistance to 5-fluorouracil affects membrane viscosity and lipid composition of cancer cells.
Topics: Cell Membrane; Fluorouracil; Microscopy, Fluorescence; Neoplasms; Phosphatidylcholines; Viscosity | 2022 |