phosphatidylcholines has been researched along with edelfosine in 34 studies
| Studies (phosphatidylcholines) | Trials (phosphatidylcholines) | Recent Studies (post-2010) (phosphatidylcholines) | Studies (edelfosine) | Trials (edelfosine) | Recent Studies (post-2010) (edelfosine) |
|---|---|---|---|---|---|
| 32,204 | 443 | 5,593 | 454 | 7 | 85 |
| Protein | Taxonomy | phosphatidylcholines (IC50) | edelfosine (IC50) |
|---|---|---|---|
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | 1.8 | |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.76) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 15 (44.12) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Hoffman, DR; Snyder, F; Thomas, VL | 1 |
| Kosano, H; Takatani, O | 1 |
| Eibl, H; Fleer, EA; Kim, DJ; Unger, C | 1 |
| Bartsch, HH; Eibl, H; Fleer, EA; Kim, DJ; Kötting, J; Nagel, GA; Pfizenmaier, K; Unger, C | 1 |
| Bennett, WD; Olson, AC; Vogler, WR; Whigham, E | 1 |
| Arthur, G; Zhou, X | 2 |
| Geilen, CC; Haase, A; Orfanos, CE; Wieder, T | 1 |
| Boggs, KP; Jackowski, S; Rock, CO | 1 |
| Algeri, M; D'Incalci, M; Damia, G; Diomede, L; Imperatori, L; Modest, EJ; Salmona, M | 1 |
| Magistrelli, A; Salmona, M; Tacconi, MT; Trulla, LL | 1 |
| Chilton, FH; Fonteh, AN; Surette, ME; Winkler, JD | 1 |
| Cabral-Lilly, DJ; Dank, EH; Dause, RB; Franklin, JC; Janoff, AS; Li, X; Mayhew, E; Perkins, WR; Zha, Y | 1 |
| Ahmad, I; Bhatia, S; Dause, R; Filep, J; Franklin, JC; Janoff, AS; Kaisheva, E; Mayhew, E; Perkins, WR; Zha, Y | 1 |
| Boggs, K; Jackowski, S; Rock, CO | 1 |
| Evers, R; Raggers, RJ; van Helvoort, A; van Meer, G | 1 |
| Aranda, FJ; de Godos, A; Gómez-Fernández, JC; Micol, V; Sánchez-Piñera, P | 1 |
| Eguchi, E; Kashiwagi, T; Meyer-Rochow, VB; Nishimura, K | 1 |
| Chen, HL; Guo, HB; Huang, CX; Huang, Y; Ma, J; Shen, ZH | 1 |
| Bruyneel, EA; Delannoy, P; Goeman, JL; Hilkens, J; Huet, G; Krzewinski-Recchi, MA; Mareel, MM; Oomen, LC; Philippé, J; Steelant, WF; Van der Eycken, J | 1 |
| Albright, CD; Craciunescu, CN; Salganik, RI; Vrablic, AS; Zeisel, SH | 1 |
| Fisher, MC; Mar, MH; Sadler, TW; Zeisel, SH | 1 |
| Bhamra, R; Bolcsak, LE; Cavanaugh, C; Roberts, P; Stevens, R; Swenson, CE | 1 |
| Birchmore, JL; Hanson, PK; Malone, L; Nichols, JW | 1 |
| Ishikawa, T; Ito, Y; Kondo, M; Kume, H; Nakayama, S; Sato, S; Shimokata, K; Son, M | 1 |
| Howe, AG; Wright, MM; Zaremberg, V | 1 |
| Croxatto, HB; Orihuela, PA; Parada-Bustamante, A; Zuñiga, LM | 1 |
| Steelant, WF; Van Slambrouck, S | 1 |
| Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T | 1 |
| Klarenbeek, JB; Perrissoud, D; Solary, E; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR | 1 |
| Fonteriz, RI; Gajate, C; López-Hernández, S; Mollinedo, F; Nieto-Miguel, T; Vay, L | 1 |
| Aranda, FJ; Ausili, A; Corbalán-García, S; de Godos, A; Gajate, C; Gómez-Fernández, JC; Mollinedo, F; Torrecillas, A | 1 |
| Baldridge, RD; Graham, TR | 1 |
| Alijas, S; Bouzo, BL; de la Fuente, M; Díez-Villares, S; Gutiérrez-Lovera, C; Lores, S; Martínez-Val, J; Pensado-López, A; Sánchez, L; Saraiva, SM; Vázquez-Ríos, AJ | 1 |
1 review(s) available for phosphatidylcholines and edelfosine
| Article | Year |
|---|---|
Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cardiolipins; Cell Membrane; Cytidine Diphosphate Choline; Mitochondria; Phosphatidylcholines; Phospholipid Ethers; Signal Transduction | 2004 |
33 other study(ies) available for phosphatidylcholines and edelfosine
| Article | Year |
|---|---|
Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells.
Topics: Antineoplastic Agents; Biological Transport; Cell Line; Cell Survival; Choline; Humans; Leukemia, Promyelocytic, Acute; Monosaccharide Transport Proteins; Phosphatidylcholines; Phospholipid Ethers; Tetradecanoylphorbol Acetate | 1992 |
Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid.
Topics: Antineoplastic Agents; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Tumor Cells, Cultured | 1988 |
Metabolism of ether phospholipids and analogs in neoplastic cells.
Topics: Animals; Cell Line; Cell Survival; Phosphatidylcholines; Phospholipid Ethers; Tumor Cells, Cultured | 1987 |
Sensitivity of leukemia cell lines to cytotoxic alkyl-lysophospholipids in relation to O-alkyl cleavage enzyme activities.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrolases; Leukemia; Leukemia L1210; Lysophosphatidylcholines; Mice; Phosphatidylcholines; Phospholipid Ethers; Phospholipids | 1987 |
Effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis in leukemic cell lines.
Topics: Carbon Radioisotopes; Cell Line; Choline; Humans; Leukemia, Myeloid; Lysophosphatidylcholines; Methionine; Phosphatidylcholines; Phospholipid Ethers; Phospholipids | 1985 |
Effect of 1-O-octadecyl-2-O-methyl-glycerophosphocholine on phosphatidylcholine and phosphatidylethanolamine synthesis in MCF-7 and A549 cells and its relationship to inhibition of cell proliferation.
Topics: Antineoplastic Agents; Cell Division; Choline; Ethanolamine; Ethanolamines; Glycerol; Oleic Acid; Oleic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers; Tumor Cells, Cultured; Water | 1995 |
The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Cell Division; Cell Line; Choline-Phosphate Cytidylyltransferase; Dogs; Kidney; Nucleotidyltransferases; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine | 1995 |
Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step.
Topics: Animals; Antineoplastic Agents; Cell Line; Choline; Choline Kinase; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Kinetics; Lysophosphatidylcholines; Macrophages; Mice; Nucleotidyltransferases; Phosphatidylcholines; Phospholipid Ethers; RNA Nucleotidyltransferases | 1995 |
In vivo anti-tumor activity of synthetic ether lipids is not enhanced by pharmacological modulation of tumor lipid composition.
Topics: Animals; Antineoplastic Agents; Cell Membrane; Cholesterol; Drug Combinations; Female; Glycerides; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Male; Membrane Fluidity; Membrane Lipids; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Ovarian Neoplasms; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers; Phospholipids; Viscosity | 1994 |
Effect of cell density on cytotoxicity of ether lipid analogues in variants of B16 murine melanoma.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Survival; Cholesterol; Melanoma, Experimental; Mice; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Sphingomyelins; Tumor Cells, Cultured | 1993 |
Relationship between arachidonate--phospholipid remodeling and apoptosis.
Topics: Acyltransferases; Apoptosis; Arachidonic Acid; Benzenesulfonates; Cell Count; Cell Division; Enzyme Inhibitors; HL-60 Cells; Humans; Imidazoles; Linoleic Acid; Linoleic Acids; Microscopy, Electron; Organophosphorus Compounds; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers; Phospholipids; Urea | 1996 |
1-O-Octadecyl-2-O-methylglycerophosphocholine inhibits protein kinase C-dependent phosphorylation of endogenous proteins in MCF-7 cells.
Topics: Biological Transport; Enzyme Inhibitors; Humans; Neoplasm Proteins; Phosphatidylcholines; Phospholipid Ethers; Phosphorylation; Protein Kinase C; Tumor Cells, Cultured | 1997 |
Combination of antitumor ether lipid with lipids of complementary molecular shape reduces its hemolytic activity.
Topics: Antineoplastic Agents; Lipids; Liposomes; Molecular Conformation; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers | 1997 |
Stability of association of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine with liposomes is composition dependent.
Topics: Centrifugation, Density Gradient; Cholesterol; Erythrocytes; Fluoresceins; Fluorescent Dyes; Hemolysis; Humans; Liposomes; Microscopy, Electron; Permeability; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers | 1997 |
The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Recombinant Proteins | 1998 |
The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane.
Topics: Animals; Cell Membrane; Cells, Cultured; DNA-Binding Proteins; Glucosylceramides; Humans; Kidney; Lipid Metabolism; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Oxadiazoles; Phosphatidylcholines; Phospholipid Ethers; Sphingolipids; Substrate Specificity; Swine; Transfection | 1999 |
Modulation of polymorphic properties of dielaidoylphosphatidylethanolamine by the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipid Ethers; X-Ray Diffraction | 1999 |
Light activation of phospholipase A2 in the photoreceptor of the crayfish (Procambarus clarkii).
Topics: Animals; Astacoidea; Cell Membrane; Dark Adaptation; Enzyme Activation; Estrenes; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Phosphatidylcholines; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Photic Stimulation; Photoreceptor Cells, Invertebrate; Pyrrolidinones; Terpenes; Vision, Ocular | 2000 |
Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
Topics: Antibodies, Monoclonal; Carcinoma, Hepatocellular; Chromones; DNA, Antisense; Enzyme Activation; Enzyme Inhibitors; Genes, ras; Humans; Liver Neoplasms; MAP Kinase Kinase Kinase 1; Morpholines; N-Acetylglucosaminyltransferases; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Transfection; Tumor Cells, Cultured | 2000 |
Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro.
Topics: Antibodies, Monoclonal; beta Catenin; Biotinylation; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Aggregation; Cell Membrane; Cell Survival; Collagen; Cytoskeletal Proteins; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Mucin-1; Neoplasm Invasiveness; Phenotype; Phosphatidylcholines; Phospholipid Ethers; Phosphorylation; Precipitin Tests; Protein Binding; Radioimmunoassay; Signal Transduction; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes.
Topics: Animals; Antigens, Polyomavirus Transforming; Antioxidants; Apoptosis; Cell Line, Transformed; Electrophoresis, Agar Gel; Hepatocytes; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Nitroblue Tetrazolium; Phosphatidylcholines; Phospholipid Ethers; Rats; Rats, Inbred F344; Reactive Oxygen Species; Tumor Suppressor Protein p53; Vitamin E | 2001 |
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
Topics: Acetylcholine; Animals; Betaine; Cells, Cultured; Central Nervous System; Ceramides; Choline; Deanol; Diglycerides; Embryo, Mammalian; Embryonic and Fetal Development; Gastrula; Mice; Models, Neurological; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Sphingomyelins | 2002 |
Toxicity and disposition of TLC ELL-12 (liposomal antitumor ether lipid) in Sprague-Dawley rats.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Carbon Isotopes; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hemolysis; Inhibitory Concentration 50; Injections, Intravenous; Liposomes; Male; Metabolic Clearance Rate; Phosphatidylcholines; Phospholipid Ethers; Rats; Rats, Sprague-Dawley; Tissue Distribution; Toxicity Tests, Acute | 2003 |
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.
Topics: Alleles; Antiprotozoal Agents; Biological Transport; Cell Division; Cell Membrane; Cycloheximide; Dose-Response Relationship, Drug; Drug Resistance; Drug Resistance, Multiple; Endocytosis; Gene Deletion; Ketoconazole; Leishmaniasis; Lipid Metabolism; Lysophosphatidylcholines; Membrane Transport Proteins; Microscopy, Fluorescence; Mutation; Nuclear Envelope; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Point Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors | 2003 |
Apical and basolateral ATP-induced anion secretion in polarized human airway epithelia.
Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Bridged-Ring Compounds; Calcium; Cell Polarity; Charybdotoxin; Chloride Channels; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Enzyme Inhibitors; Epithelial Cells; Humans; Lung; Norbornanes; Phosphatidylcholines; Phosphatidylinositols; Phospholipid Ethers; Potassium; Potassium Channels, Calcium-Activated; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thiocarbamates; Thiones; Type C Phospholipases | 2004 |
Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estradiol; Estrus; Fallopian Tubes; Female; Flavonoids; Inositol Phosphates; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Oocytes; Ovum Transport; Phosphatidylcholines; Phospholipid Ethers; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases | 2006 |
Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Glycosphingolipids; Humans; Integrins; Matrix Metalloproteinases; Membrane Microdomains; Neoplasm Invasiveness; Phosphatidylcholines; Phospholipid Ethers; Signal Transduction | 2007 |
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic | 2007 |
A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endocytosis; HeLa Cells; Humans; Lymphoma; Membrane Microdomains; Mice; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Sphingomyelins; Time Factors | 2007 |
Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Calcium; Caspases; Choline-Phosphate Cytidylyltransferase; Endoplasmic Reticulum; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; Neoplasms; Phosphatidylcholines; Phospholipid Ethers; Protein Synthesis Inhibitors | 2007 |
Edelfosine is incorporated into rafts and alters their organization.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Cell Membrane; Cholesterol; Humans; Jurkat Cells; Magnetic Resonance Spectroscopy; Phase Transition; Phosphatidylcholines; Phosphodiesterase Inhibitors; Phospholipid Ethers; Sphingomyelins; Temperature; X-Ray Diffraction | 2008 |
Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acids; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport; Blotting, Western; Calcium-Transporting ATPases; Cell Membrane; Green Fluorescent Proteins; Lipid Bilayers; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutation; Phosphatidylcholines; Phosphatidylserines; Phospholipid Ethers; Phospholipids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2013 |
Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model.
Topics: Administration, Cutaneous; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Compounding; Emulsions; Excipients; Female; Humans; Nanoparticles; Permeability; Phosphatidylcholines; Phospholipid Ethers; Skin; Triglycerides; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays; Zebrafish | 2021 |