phorbols has been researched along with tetradecanoylphorbol acetate in 1753 studies
| Studies (phorbols) | Trials (phorbols) | Recent Studies (post-2010) (phorbols) | Studies (tetradecanoylphorbol acetate) | Trials (tetradecanoylphorbol acetate) | Recent Studies (post-2010) (tetradecanoylphorbol acetate) |
|---|---|---|---|---|---|
| 2,217 | 0 | 72 | 31,050 | 61 | 2,217 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1720 (98.12) | 18.7374 |
| 1990's | 21 (1.20) | 18.2507 |
| 2000's | 10 (0.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (0.11) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, FJ; Kinghorn, AD; Soper, CJ | 1 |
| Iversen, OH; Iversen, UM | 2 |
| Bias, NE; Helson, L; Kopelovich, L | 1 |
| Christman, JK; Copp, RP; Pedrinan, L; Whalen, CE | 1 |
| Knowles, MA | 1 |
| Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 7 |
| Melchionne, S; Segal, A; Seidman, I; Smith, AC; Tseng, SS; Van Duuren, BL | 1 |
| Fisher, PB; Goldstein, NI; Weinstein, IB | 1 |
| Bracken, WM; Gleason, GL; Hennings, H; Slaga, TJ; Weeks, CE | 1 |
| Nettesheim, P; Terzaghi, M | 1 |
| Banerjee, S; Witz, G | 1 |
| Armuth, V; Berenblum, I | 1 |
| Balmain, A; Hecker, E | 1 |
| Goerttler, K; Löhrke, H | 1 |
| Scribner, JD; Süss, R | 1 |
| Krupa, TA; Mastro, AM; Smith, P | 1 |
| Banerjee, S; van Duuren, BL; Witz, G | 1 |
| Boutwell, RK; Mufson, RA; Simsiman, RC | 2 |
| Astrup, EG; Boutwell, RK; Mufson, RA; Simsiman, RC | 1 |
| Froscio, M; Murray, AW | 2 |
| Blumberg, PM; Driedger, PE | 5 |
| Sivak, A | 1 |
| Freese, UK; Hecker, E; O'Neill, FJ; zur Hausen, H | 1 |
| Beall, GD; Hoidal, JR; Rasp, FL; Repine, JE; White, JG | 1 |
| Belman, S; Garte, SJ; Troll, W | 1 |
| Belman, S; Garte, SJ | 6 |
| Goldfarb, RH; Quigley, JP | 2 |
| Reich, E; Wilson, EL | 2 |
| Easton, TG; Maelicke, A; Miskin, R; Reich, E | 1 |
| Easton, TG; Miskin, R; Reich, E | 1 |
| Bissell, MJ; Calvin, M; Hatié, C | 1 |
| Blumberg, PM; Delclos, KB | 1 |
| Fürstenberger, G; Marks, F | 5 |
| Abb, J; Bayliss, GJ; Deinhardt, F | 1 |
| Yamamoto, N; zur Hausen, H | 2 |
| Quigley, JP | 1 |
| Castagna, M; Rochette-Egly, C | 1 |
| Brinckerhoff, CE; Fahey, JV; Harris, ED; McMillan, RM | 1 |
| Lin, JC; Pagano, JS; Shaw, JE; Smith, MC | 1 |
| Boutwell, RK; Fischer, SM; Gleason, GL; Mufson, RA; Slaga, TJ; Verma, AK | 1 |
| Castagna, M; Chouroulinkov, I; Rochette-Egly, C | 2 |
| Griffel, B; Honig, S; Pick, E; Seger, M | 1 |
| Bowden, GT; Magun, BE | 1 |
| Eisenberg, D; Fisher, PB; Ginsberg, HS; Weinstein, IB | 1 |
| Fibach, E; Marks, PA; Rifkind, RA; Weinstein, IB; Yamasaki, H | 2 |
| Kinsella, AR; Radman, M | 1 |
| Castagna, M; Rochette-Egly, C; Rosenfeld, C | 1 |
| Diamond, L; O'Brien, TG; Rovera, G | 1 |
| Honma, Y; Hozumi, M; Kasukabe, T | 5 |
| Fibach, E; Gambari, R; Maniatis, G; Marks, PA; Reuben, RC; Rifkind, RA; Sassa, S; Shaw, PA | 1 |
| Little, JB; Nagasawa, H | 2 |
| Damsky, C; Rovera, G; Santoli, D | 1 |
| Mufson, RA; Weinstein, IB; Yamasaki, H | 1 |
| Aoki, N; Miwa, M; Nakayasu, M; Sato, S; Shoji, M; Sugimura, T | 1 |
| Lotem, J; Sachs, L | 2 |
| Clarkson, BD; Khollend, JF; Svet-Moldavskiĭ, GIa; Svet-Moldavskiĭ, IA | 1 |
| Arlin, Z; Bekesi, JG; Clarkson, BD; Holland, JF; Koziner, B; Mann, PE; Svet-Moldavskaya, IA; Svet-Moldavsky, GJ; Zinzar, SN | 1 |
| Estensen, R; Good, RA; Hadden, EM; Hadden, JW; Touraine, F; Touraine, JL | 1 |
| Lee, LS; Weinstein, IB | 4 |
| Kensler, TW; Mueller, GC; Wertz, PW | 2 |
| Acs, G; Christman, J; Kyner, D; Mendelsohn, N; Schreiber, C; Waxman, S; Zabos, P | 1 |
| Dicker, P; Rozengurt, E | 7 |
| Strannegård, IL | 1 |
| Brown, KD; Dicker, P; Rozengurt, E | 1 |
| Fusenig, NE; Murray, AW | 1 |
| Mizel, SB; Rosenstreich, DL | 1 |
| Frantz, CN; Scher, CD; Stiles, CD | 1 |
| Acs, G; Christman, JK; Kyner, D | 1 |
| Bozzone, JH; Fisher, PB; Weinstein, IB | 1 |
| Estensen, RD; Steffes, MW; Virji, MA | 1 |
| Fisher, PB; Lee, LS; Mufson, A; Weinstein, IB; Yamasaki, H | 1 |
| Evans, FJ; Soper, CJ | 1 |
| Marks, F; Schweizer, J | 1 |
| Boutwell, RK; Rice, HM; Verma, AK | 1 |
| Griesemer, RA; Nelson, FR; Nettesheim, P; Pal, BC; Topping, DC | 1 |
| Fisher, PB; Flamm, M; Schachter, D; Weinstein, IB | 1 |
| Castagna, M; Mishal, Z; Rochette-Egly, C; Rosenfeld, C | 1 |
| Heckman, C; Huberman, E; Langenbach, R | 1 |
| Rasmussen, B; Repine, JE; White, JG | 1 |
| Diamond, L; O'Brien, TG; Saladik, D | 3 |
| Jones, OT; Segal, AW | 1 |
| Skinnider, LF | 1 |
| Kerr, SJ; Sharma, OK | 1 |
| Diamant, S; Fridkin, M; Spirer, Z; Stabinsky, Y; Zakuth, V | 1 |
| Bhide, SV; Bhisey, RA; Sirsat, SM | 1 |
| Bresnick, E; Lamden, M; Meunier, P | 1 |
| Fisher, PB; Mufson, RA; Weinstein, IB | 1 |
| Giesbrecht, K; Skinnider, LF | 2 |
| Eakins, KE; Kulkarni, P; Mufson, RA; Weinstein, IB | 1 |
| Evans, FJ; Schmidt, RJ | 1 |
| Latt, SA; Loveday, KS | 1 |
| Kennedy, AR; Little, JB; Nagasawa, H | 1 |
| Colburn, NH; Former, BF; Nelson, KA; Yuspa, SH | 1 |
| Dorsch-Häsler, K; Fisher, PB; Ginsberg, HS; Weinstein, IB | 1 |
| Chang, CC; Trosko, JE; Yotti, LP | 1 |
| Diamond, L; Lewis, MA; O'Brien, TG | 1 |
| Ashendel, CL; Boutwell, RK | 2 |
| Keller, R | 1 |
| Holtzer, H; Toyama, Y; West, CM | 1 |
| Iden, SS; Smith, RJ | 1 |
| Fitzgerald, DJ; Murray, AW | 1 |
| Schweizer, J | 2 |
| Slaga, TJ; Weeks, CE | 1 |
| de Loecker, W; Janssens, JP | 1 |
| Diamond, L; O'Brien, TG | 4 |
| Hagerman, DD | 1 |
| Boutwell, RK; Kensler, TW; Mueller, GC; Verma, AK; Wertz, PW | 1 |
| Brankow, DW; Heidelberger, C; Mondal, S; Peterson, AR; Thon, W | 1 |
| Holtzer, H; Pacifici, M | 1 |
| Hecker, E; Kinzel, V; Kreibich, G; Süss, R | 1 |
| Crowe, RM; Pollack, R; Rifkin, DB | 1 |
| Dobbs, LG; Mason, RJ | 1 |
| Heidelberger, C; Kennedy, AR; Little, JB; Mondal, S | 1 |
| Elgjo, K; Hennings, H; Lichti, U; Slaga, TJ; Yuspa, SH | 1 |
| Kensler, TW; Mueller, GC | 1 |
| Boutwell, RK; Rice, HM; Shapas, BG; Verma, AK | 2 |
| Dunn, P; Overgaard, M; Sedlacek, R; Suit, H; Urano, M | 1 |
| Melchionne, SM; Smith, AC; Van Duuren, BL | 1 |
| Solomon, JJ; Tseng, SS; Van Duuren, BL | 2 |
| Maté, U; Melchionne, S; Segal, A; Seidman, I; Smith, A; Solomon, JJ; Van Duuren, BL | 1 |
| DeFeo, D; Weinstein, IB; Wigler, M | 1 |
| Fibach, E; Ishii, DN; Weinstein, IB; Yamasaki, H | 1 |
| Moroney, J; Smith, A; Tomei, LD; Wenner, CE | 1 |
| Repine, JE; White, JG | 1 |
| Murray, AW | 1 |
| Levine, L; Ohuchi, K | 4 |
| Berry, DL; Bracken, WM; Fischer, SM; Slaga, TJ; Viaje, A | 1 |
| Holtzer, H; Lowe, ME; Pacifici, M | 1 |
| Boutwell, RK; Kensler, TW; Mueller, GC; Verma, AK | 1 |
| Mueller, GC; Wertz, PW | 3 |
| Filedsteel, AH; Fodge, DW; Miao, RM | 1 |
| Marchok, AC; Nettesheim, P; Steele, VE | 2 |
| Biggar, WD | 1 |
| Ishii, DN | 1 |
| Mizel, SB; Oppenheim, JJ; Rosenstreich, DL | 1 |
| Beall, GD; Hoidal, JR; Holmes, B; Rasp, FL; Repine, JE; White, JG | 1 |
| Boutwell, RK; Raineri, R; Simsiman, RC | 2 |
| Cooney, MH; Pryzwansky, KB; Spitznagel, JK; Wang-Iverson, P | 1 |
| Arendt, U; Bresch, H | 1 |
| Argent, BE; Case, RM; Hirst, FC | 1 |
| Pienta, RJ; Poiley, JA; Raineri, R | 1 |
| Segal, A; Van Duuren, BL | 1 |
| Brankow, DW; Heidelberger, C; Mondal, S | 1 |
| Scribner, JD; Slaga, TJ; Viaje, A | 1 |
| Goerttler, K; Loehrke, H | 2 |
| Chang, CC; Chu, EH; Trosko, JE; Yotti, LP | 1 |
| Alonso, A; Balmain, A; Fischer, J | 1 |
| Slaga, TJ; Viaje, A; Weinstein, IB; Wigler, M | 1 |
| Biehl, J; Cohen, R; Holtzer, H; Pacifici, M; Rubinstein, N | 1 |
| Boutwell, RK; Verma, AK | 4 |
| Berry, DL; Fischer, SM; Lieber, MR; Slaga, TJ | 1 |
| Balmain, A | 1 |
| Boutwell, RK; O'Brien, TG; Simsiman, RC | 1 |
| DeChatelet, LR; McPhail, LC; Shirley, PS | 1 |
| Ben, T; Elgjo, K; Hennings, H; Michael, D; Patterson, E; Yuspa, SH | 1 |
| Bhisey, RA; Sirsat, SM | 1 |
| Huffman, JC; Wilson, SR | 1 |
| Blumberg, PM; Driedger, PE; Rossow, PW | 1 |
| De Cicco, BT; Lieberman, MW; Poirier, MC | 1 |
| Maté, U; Segal, A; Van Duuren, BL | 1 |
| Goldstein, IM; Hoffstein, ST; Weissmann, G | 1 |
| Colburn, NH; Head, R; Lau, S | 1 |
| Kuszynski, C; Langenbach, R | 1 |
| Boynton, AL; Isaacs, RJ; Whitfield, JF | 1 |
| Weinstein, IB; Wigler, M | 1 |
| DeChatelet, LR; Johnston, RB; Shirley, PS | 1 |
| Paradiso, AM | 1 |
| Bosca, L; Cascales, M; Martin-Sanz, P | 1 |
| Andrews, PE; Montgomery, BT; Tindall, DJ; Young, CY | 1 |
| Byrne, JH; Critz, SD | 1 |
| Raufman, JP | 1 |
| Gross, JL; Horuk, R | 1 |
| Chaikin, E; Razin, E; Ziltener, HJ | 1 |
| Alterman, RL; Kornblith, PL; Maleci, A; Moskal, JR; Sundstrom, D | 1 |
| Salo, T; Tryggvason, K; Turpeenniemi-Hujanen, T | 1 |
| Wooten, MW; Wrenn, RW | 2 |
| Crowcroft, NS; Parkinson, EK; Quigley, JP; Stanley, MA | 1 |
| Owen, NE | 1 |
| Crews, FT; Heiman, AS | 2 |
| Montesano, R; Orci, L | 1 |
| Carson, JL; Stedman, DB; Welsch, F | 1 |
| Albert, F; Golstein, P; Schmitt-Verhulst, AM; Truneh, A | 1 |
| Johnson, HM; Torres, BA | 1 |
| Foreman, JC; Sagi-Eisenberg, R; Shelly, R | 1 |
| Roop, DR; Toftgard, R; Yuspa, SH | 1 |
| Field, JB; Nielsen, TB; Rani, CS; Tanabe, A | 1 |
| Nakashima, S; Nozawa, Y; Okano, Y; Takagi, H; Tohmatsu, T | 1 |
| Parkinson, EK | 1 |
| Colamonici, OR; Neckers, LM; Trepel, JB | 1 |
| Altukhova, IP; Avdonin, PV | 1 |
| Di Virgilio, F; Meldolesi, J; Pozzan, T; Vicentini, LM; Wollheim, CB | 1 |
| Rutledge, BK; Schleimer, RP | 1 |
| Ishihara, N; Kobayashi, B; Nagao, K | 1 |
| Fischer, GF; Holter, W; Knapp, W; Majdic, O; Stockinger, H | 1 |
| Ichida, T; Takuma, T | 1 |
| Casnellie, JE; Lamberts, RJ | 1 |
| Murray, N; Steck, AJ | 1 |
| Loewenstein, WR; Rose, B; Yada, T | 1 |
| Rillema, JA; Waters, SB | 1 |
| Bailly, J; Bernard, BA; Darmon, YM; Delescluse, C | 1 |
| Adams, DO; Hamilton, TA; Somers, SD; Weiel, JE | 1 |
| Benjamin, TL; Matthews, JT | 1 |
| Eckhardt, L; Imamura, K; Kimura, T; Schulz, I | 1 |
| Christensen, SB; Fujiki, H; Hakii, H; Hirasawa, N; Ohuchi, K; Suganuma, M; Sugimura, T; Takahashi, C; Tsurufuji, S; Watanabe, M | 1 |
| Ben-Ze'ev, A | 1 |
| Long, CW; Suk, WA | 1 |
| Bernard, A; Blanc, C; De Roquefeuil, S; Debre, P; Triebel, F | 1 |
| Arai, S; Fujii, Y; Gotoh, S; Itoh, M; Sendo, F | 1 |
| Cantwell, ME; Foreman, JC | 1 |
| Furuya, W; Grinstein, S | 1 |
| Nozawa, Y; Okano, Y; Takagi, H; Yamada, K | 1 |
| Blackmore, PF; Exton, JH | 1 |
| Burnham, DB; Hootman, SR; Munowitz, P; Williams, JA | 1 |
| Giacomoni, PU | 1 |
| Bonavida, B; Bramhall, J; Graves, SS | 1 |
| Burton, DW; Deftos, LJ; Murray, SS | 1 |
| Choi, EJ; Toscano, WA | 1 |
| Hogans, BB; Spivak, JL; Stuart, RK | 1 |
| Singh, J | 1 |
| Fürstenberger, G; Marks, F; Schweizer, J | 1 |
| Behnke, O; Olsson, L; Sørensen, HR | 1 |
| Elder, B; Furuya, W; Grinstein, S | 1 |
| Cooper, MD; Suzuki, T | 1 |
| Battistella, A; Bigon, E; Bruni, A; Mietto, L; Palatini, P; Toffano, G | 1 |
| Blackwell, GJ; Bonser, RW; Dawson, J; Garland, LG | 1 |
| Abrahamsson, L; Esscher, T; Jergil, B; Mattsson, M; Påhlman, S; Ruusala, AI | 1 |
| Esteve, JP; Ribet, A; Susini, C; Vaysse, N; Viguerie, N; Zeggari, M | 1 |
| Hoshi, T; Shimada, T | 1 |
| Hirata, Y | 1 |
| Morgan, EH; Sorokin, LM; Yeoh, GC | 1 |
| Bell, JD; Brunton, LL; Buxton, IL | 1 |
| Fujiki, H; Levine, L; Ohuchi, K; Suganuma, M; Sugimura, T; Tsurufuji, S; Watanabe, M; Yoshizawa, K | 1 |
| Beguinot, L; Hanover, JA; Ito, S; Pastan, I; Richert, ND; Willingham, MC | 1 |
| Zisapel, N; Zurgil, N | 1 |
| Goldman, R | 1 |
| Verma, AK | 1 |
| Canonico, PL; Cronin, MJ; MacLeod, RM; Rogol, AD; Summers, ST | 1 |
| Fishman, PH; Kassis, S; Patel, J; Zaremba, T | 1 |
| Haddox, MK; Maddox, AM | 1 |
| Goodman, S; Koontz, JW | 1 |
| Iversen, OH | 1 |
| Chiba, T; Chihara, K; Fujita, T; Fukase, M; Kadowaki, S; Yamatani, T | 1 |
| Fujiki, H; Levine, L; Xiao, D | 1 |
| Baba, S; Matozaki, T; Nagao, M; Sakamoto, C | 2 |
| Berge, RK; Lillehaug, JR | 1 |
| Ikeda, H; Kubota, K; Kuzuya, N; Mitsuhashi, T; Uchimura, H | 1 |
| Caratsch, CG; Eusebi, F; Molinaro, M | 1 |
| Glasø, M; Hovig, T; Iversen, OH; Ree, K | 1 |
| Fujiki, H | 1 |
| Sorenson, RL | 1 |
| Fujiki, H; Levine, L; Xiao, DM | 1 |
| Dan'ura, T; Higashi, K; Ishibashi, S; Kurokawa, T; Yamashita, A | 1 |
| Coffey, RG | 1 |
| Insel, PA; Slivka, SR | 1 |
| Entwistle, A; Farzaneh, F; Zalin, RJ | 1 |
| Bauer, KD; Dunn, MM; Kamp, DW; Rubin, DB | 1 |
| Bosca, L; Hue, L; Rousseau, GG | 1 |
| Daveau, M; Fontaine, M; Gilbert, D; Peulve, P; Ripoche, J | 1 |
| Beery, E; Nordenberg, J; Novogrodsky, A; Stenzel, KH | 1 |
| Levine, L; Rigas, A; Snoek, GT | 1 |
| Meyer, BC; Wright, SD | 1 |
| McCormick, DL; Moon, RC | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Kanno, Y; Sasaki, Y; Shiba, Y | 1 |
| Adams, DO; Hamilton, TA; Weiel, JE | 1 |
| Lomnitzer, R; Phillips, R; Rabson, AR | 1 |
| Berube, ML; Sedgwick, JB; Zurier, RB | 1 |
| Friesen, HG; Ohmura, E | 1 |
| Hall, M; Saggerson, ED; Taylor, SJ | 1 |
| Drummond, AH; MacIntyre, DE; McNicol, A | 1 |
| Földes, I; Markovits, A; Premecz, G | 1 |
| Bell, RM; Czech, MP; Davis, RJ; Ganong, BR | 2 |
| Colburn, NH; Gindhart, TD; Nakamura, Y | 1 |
| Bachrach, LK; Burrow, GN; Eggo, MC; Mak, WW | 1 |
| Ito, Y; Kawanishi, M | 1 |
| Borgeat, P; Molski, TF; Naccache, PH; Sha'afi, RI; White, JR | 1 |
| Blackmore, PF; Bocckino, SB; Charest, R; Exton, JH; Lynch, CJ | 1 |
| Murphy, G; Reynolds, JJ; Werb, Z | 1 |
| Butler, JL; Cooper, MD; Suzuki, T | 1 |
| Cerutti, P; Poirier, G; Singh, N | 2 |
| Ambrosini, A; Di Virgilio, F; Meldolesi, J; Pozzan, T; Vicentini, LM | 1 |
| Schwartz, AG; Whitcomb, JM | 1 |
| Davis, R; Like, B; Massagué, J | 1 |
| Czech, MP; Davis, RJ | 4 |
| Minta, JO; Pambrun, L | 1 |
| De Wit, RJ; Van Haastert, PJ; Van Lookeren Campagne, MM | 1 |
| Ando, I; Beverley, PC; Crawford, DH; Kissonerghis, MA; Owen, MJ | 1 |
| Niki, A; Niki, H; Tamagawa, T | 1 |
| Brown, JH; Orellana, SA; Solski, PA | 1 |
| Boonstra, J; de Laat, SW; Mummery, CL; van der Saag, PT | 1 |
| Civan, MM; Mauro, T; O'Brien, TG; Rubenstein, D | 1 |
| Benson, CE; Boy, MG; Dyer, RM | 1 |
| Feinstein, MB; Molski, TF; Naccache, PH; Sha'afi, RI; Volpi, M | 1 |
| Cassatella, M; De Togni, P; Della Bianca, V; Grzeskowiak, M; Rossi, F | 1 |
| Publicover, SJ | 1 |
| Clark, MR; Kawai, Y | 1 |
| Benveniste, R; Ilekis, J | 1 |
| Daly, JW; Hollingsworth, EB; Sears, EB | 1 |
| Caldwell, AB; Kreutter, D; Morin, MJ | 1 |
| Durbin, L; Higson, FK; Pavlotsky, N; Tauber, AI | 1 |
| Feinstein, MB; Halenda, SP; Sha'afi, RI; Zavoico, GB | 1 |
| Galbraith, RM; Goldschmidt-Clermont, PJ; Miller, PJ; Nel, AE; Stevenson, HC; Wooten, MW | 1 |
| Inui, N; Iwata, K; Ohkawa, Y; Shibuya, H | 1 |
| Adams, LM; Fischer, SM | 1 |
| Kohno, H; Taketani, S; Tokunaga, R | 2 |
| Johnson, DD; Phan, NT; Sulakhe, PV; Wilcox, R | 1 |
| Frelin, C; Lazdunski, M; Vigne, P | 1 |
| Patel, J; Rebois, RV | 1 |
| Abramian, DS; Glebov, OK; Tomilin, NV | 1 |
| Beresford, BJ; Boon, AM; Mellors, A | 1 |
| Deuel, T; Glaser, L; Whiteley, B | 1 |
| Gescher, A | 1 |
| Gawler, DJ; Heyworth, CM; Houslay, MD; Wilson, SP | 1 |
| Horne, WC; Leto, TL; Marchesi, VT | 1 |
| Cuatrecasas, P; Jacobs, S; May, WS; Sahyoun, N; Wolf, M | 1 |
| O'Connor, TW | 1 |
| Clark, SD; Stricklin, GP; Welgus, HG; Wilhelm, SM | 1 |
| Becker, EL; Molski, MM; Naccache, PH; Sha'afi, RI; Volpi, M | 1 |
| Altman, A; Bleackley, RC; Isakov, N; Shaw, J | 1 |
| Rivedal, E; Sanner, T | 2 |
| Gupta, RS; Singh, B; Stetsko, DK | 1 |
| Houchi, H; Nakanishi, A; Ohuchi, T; Oka, M; Uddin, MM | 1 |
| Carreau, S; Drosdowsky, MA; Papadopoulos, V | 1 |
| Bartmann, P; Brudler, O; Kabelitz, D; Nerl, C; Pfeffer, K; von Steldern, D; Wagner, H | 1 |
| Caron, MG; Cotecchia, S; DeBernardis, JF; Leeb-Lundberg, LM; Lefkowitz, RJ; Lomasney, JW | 1 |
| Madshus, IH; Olsnes, S; Sandvig, K | 1 |
| Levine, SD; Schlondorff, D | 1 |
| Mazón, MJ; Portillo, F | 1 |
| Alexander, RW; Brock, TA; Ekstein, LS; Gimbrone, MA; Powers, CW; Rittenhouse, SE | 1 |
| Kiss, Z; Steinberg, RA | 2 |
| Asai, S; Bayliss, GJ; Ito, Y; Namikawa, I; Wolf, H | 1 |
| Andoh, T; Gatanaga, T; Kitahara, N; Morioka, H; Murata, M; Shibai, H; Soma, G | 1 |
| Fujita, T; Fukase, M; Hishikawa, R; Kadowaki, S; Yamatani, T | 1 |
| Aberdam, E; Dekel, N | 1 |
| Aublin, JL; Champion, S; Haye, B; Jacquemin, C; Lambert, B | 1 |
| Molski, MM; Naccache, PH; Sha'afi, RI | 1 |
| Chen, KY; Liu, AY | 1 |
| Ashby, B; Daniel, JL; Kowalska, MA; Rigmaiden, M; Smith, JB; Wernick, E | 1 |
| Vicentini, LM; Villereal, ML | 2 |
| Corvera, S; García-Sáinz, JA; Graham, RM; Schwarz, KR | 1 |
| Clark, AJ; Ishii, S; Merlino, GT; Pastan, I; Richert, N | 1 |
| Garte, SJ | 1 |
| Costa-Casnellie, MR; Lichtman, MA; Segel, GB | 1 |
| Holter, W; Knapp, W; Majdic, O; Stockinger, H | 1 |
| Bohnet, HG; Brunswig, B; Budnik, LT; Leidenberger, FA; Mukhopadhyay, AK | 1 |
| Daly, JW; Hollingsworth, EB; Ukena, D | 1 |
| Greene, DA; Lattimer, SA | 1 |
| Bowen-Pope, DF; Eide, BL; Krebs, EG; Pike, LJ; Ross, R | 1 |
| Angel, P; Herrlich, P; Lücke-Huhle, C; Pöting, A; Rahmsdorf, HJ | 1 |
| Hattori, H; Nagao, S; Nozawa, Y; Ohki, K; Tohmatsu, T | 1 |
| Kraft, AS | 1 |
| Avdonin, PV; Bugriĭ, EM; Mazaev, AV; Tkachuk, VA | 1 |
| Horecker, BL; Melloni, E; Michetti, M; Pontremoli, S; Sacco, O; Sparatore, B | 1 |
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| Krammer, PH; Northoff, H; Stoeck, M | 1 |
| Kaplan, JH; Lee, LS; Lockwood, SH | 1 |
| Arnold, A; Cossman, J; Korsmeyer, SJ; Neckers, LM | 1 |
| de Vries, JE; van der Reijden, HJ; Vyth-Dreese, FA | 1 |
| Baxter, CS; Ferguson, TA; Fish, LA; Michael, JG | 1 |
| Sugawara, I | 1 |
| Forbes, IJ; Valente, L; Zalewski, PD | 1 |
| DeMarinis, AJ; DiPaolo, JA; Doniger, J; Evans, CH | 1 |
| Hiragun, A; Ishimura, K; Mitsui, H | 1 |
| Biehl, J; Holtzer, H; Holtzer, S; Payette, R; Toyama, Y | 1 |
| Chambers, DA; Krueger, GG; Shelby, J | 1 |
| Croop, J; Dlugosz, AA; Holtzer, H; Toyama, Y | 1 |
| Blumberg, PM | 2 |
| Cohn, ZA; Kielian, MC | 1 |
| Friedman, EA | 1 |
| Croop, J; Dlugosz, A; Dubyak, G; Holtzer, H; Scarpa, A; Toyama, Y | 1 |
| Bollum, FJ; Kersey, JH; LeBien, TW; Yasmineh, WG | 1 |
| Donovan, PA; Hart, IR; Talmadge, JE | 1 |
| Croop, J; Dlugosz, A; Holtzer, H; Pacifici, M; Payette, R; Toyama, Y | 1 |
| Brune, K; Lanz, R | 2 |
| Blumberg, PM; Delclos, KB; Dunphy, WG; Jaken, S | 1 |
| Hecker, E; Keist, R; Keller, R; Köppel, P | 1 |
| O'Brien, TG | 1 |
| Hiragun, A; Mitsui, H; Sato, M | 1 |
| Barrett, JC; Brown, MT; Sisskin, EE | 1 |
| Badaracco, G; Bertazzoni, U; Breviario, D; Ginelli, E; Plevani, P; Sacchi, N | 1 |
| Fantone, JC; Varani, J | 1 |
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| Hecker, E; Keist, R; Keller, R | 1 |
| Boutwell, RK; O'Leary, P; Perrella, FW | 1 |
| Kinzel, V; Krombholz-Nolinski, I; Richards, J; Stöhr, M | 1 |
| Bhisey, RA; Iyengar, B; Sirsat, SM | 1 |
| Johnson, KJ; Ward, PA | 1 |
| Colburn, NH; Dion, LD; Wendel, EJ | 1 |
| Berry, DL; Fürstenberger, G; Marks, F; Slaga, TJ | 1 |
| Hennings, H; Holbrook, K; Lichti, U; Yuspa, SH | 1 |
| Sasse, J; von der Mark, K | 1 |
| Kinzel, V; Richards, J; Stöhr, M | 4 |
| Hecker, E; Schmidt, R | 1 |
| Fitzgerald, DJ; Guy, GR; Murray, AW | 1 |
| Amsbaugh, SC; DiPaolo, JA; Larramendy, ML; Popescu, NC | 1 |
| Boynton, AL; Jones, A; MacManus, JP; Whitfield, JF | 1 |
| Adamo, S; Bouché, M; Cossu, G; Molinaro, M; Pacifici, M | 1 |
| Conkling, PR; Klassen, DK; Sagone, AL | 1 |
| Mottola, C; Romeo, D | 1 |
| McMurtry, I; Repine, JE; Shasby, DM; Shasby, SS; Tate, RM; Vanbenthuysen, KM | 1 |
| Currens, M; Iype, PT; Ray-Chaudhuri, R | 1 |
| Ellinger, MS | 1 |
| Chang, CC; Edens, JE; Revel, JP; Trosko, JE; Yancey, SB | 1 |
| Shiba, Y | 1 |
| Castagna, M; Kaibuchi, K; Kikkawa, U; Nishizuka, Y; Sano, K; Takai, Y | 1 |
| Backer, JM; Boersig, MR; Weinstein, IB | 1 |
| Grove, RI; Schimmel, SD | 2 |
| Cornaglia-Ferraris, P; Lambertenghi-Deliliers, G; Lancieri, M; Monaco, G; Revoltella, R; Vigneti, E | 1 |
| Bennett, M; Fredrickson, GG | 1 |
| Hamby, KM; Miller, DR; Slaga, TJ | 1 |
| Bourin, MC; Delescluse, C; Fürstenberger, G; Klein-Szanto, AJ; Marks, F; Prunieras, M; Schweizer, J | 1 |
| Gerschenson, LE; Lake, LM; Murai, JT | 1 |
| Richter, C; Stocker, R; Winterhalter, KH | 1 |
| Hirai, KI; Kanoh, T; Ogawa, K; Ohno, YI; Uchino, H | 1 |
| Blumberg, PM; Burstein, DE; Greene, LA | 1 |
| Adler, WH; Chrest, FJ; Nagel, JE | 1 |
| Hino, O; Kayano, T; Kitagawa, T; Nomura, K | 1 |
| Furusawa, M; Miwa, J; Tabuse, Y; Yamasaki, H | 1 |
| Gambari, R | 1 |
| Ishii, DN; Sonnenfeld, KH; Spinelli, W | 1 |
| Friedman, EA; Steinberg, M | 1 |
| Keist, R; Keller, R | 1 |
| Anderson, WB; Cooper, HL; Kraft, AS; Sando, JJ | 1 |
| Peters, TJ; Smith, GP | 1 |
| Düzgün, F; Kinzel, V; Richards, J | 1 |
| Fischer, SM; Mills, GD; Slaga, TJ | 1 |
| Biggar, WD; Birnboim, HC | 1 |
| Silverstein, SC; Wright, SD | 1 |
| Holtzer, H; West, CM | 1 |
| Holtzer, H; Pacifici, M; Sasse, J; von der Mark, K | 1 |
| Boutwell, RK; Conrad, EA; Kishore, GS; Perchellet, JP | 1 |
| Mullin, JM; O'Brien, TG; Saladik, D; Sina, JF | 1 |
| Adamo, S; Caporale, C; Cossu, G; Molinaro, M | 1 |
| Bols, NC; Mosser, DD | 1 |
| Hyodo, S; Kittaka, E; Sakano, T; Tanaka, Y; Usui, T | 1 |
| Grzelakowska-Sztabert, B | 1 |
| Castagna, M; Fridman, WH; Rabourdin-Combe, C; Yagello, M | 1 |
| Bias, NE; Kopelovich, L | 1 |
| Cabot, MC; Callaham, MF; Huberman, E; Welsh, CJ | 1 |
| Estensen, RD; Plagemann, PG | 1 |
| Claisse, PJ; Hince, TA; Roscoe, JP; Winslow, DP | 1 |
| Tsan, MF | 1 |
| Conanan, LB; Crutchley, DJ; Maynard, JR | 1 |
| Ojakian, GK | 1 |
| Dientsman, SR; Hamilton, JA | 1 |
| Black, PH; Geffen, C; Jaken, S | 1 |
| Weinberg, JB | 1 |
| Black, PH; Jaken, S | 1 |
| Banda, MJ; Schwartz, JL; Wolff, S | 1 |
| Chang, CC; Moskal, JR; Trosko, JE; Warren, ST; Yotti, LP | 1 |
| Byus, CV; Weiner, RA | 1 |
| Gillespie, E | 1 |
| Sivak, A; Tu, AS | 1 |
| Cho, CH; Pfeiffer, CJ | 1 |
| Fisher, PB; Weinstein, IB | 1 |
| Grotendorst, GR; Grove, RI; Schimmel, SD | 1 |
| Glimelius, B; Weston, JA | 1 |
| Noda, K; Ono, T; Umeda, M | 1 |
| Boutwell, RK; Kishore, GS | 1 |
| Fürstenberger, G; Fusenig, NE; Marks, F; Richter, H | 1 |
| Romeo, D; Schneider, C; Zanetti, M | 1 |
| Gentil, A; Margot, A; Renault, G | 1 |
| Hennings, H; Lichti, U; Patterson, E; Yuspa, SH | 2 |
| Cheney, JC; Tomei, LD; Wenner, CE | 1 |
| Shah, SV | 1 |
| Fujiwara, Y; Tatsumi, M | 1 |
| Kitamura, Y; Sasaki, K; Taguchi, Y; Tsuyama, K; Watanabe, T | 1 |
| Boutwell, RK; Goldfarb, S; Kishore, GS; Paton, BC; Ramasarma, T | 1 |
| Pack, GR | 1 |
| Amtmann, E; Krieg, P; Sauer, G | 1 |
| Blumberg, PM; Dunphy, WG; Lau, CC | 1 |
| Kinsella, AR | 1 |
| Roberts, MF; Tauber, AI | 1 |
| Varshavsky, A | 1 |
| Connell, JR; Duncan, SJ | 1 |
| Colburn, NH; De Luca, LM; Dion, LD | 1 |
| Chen, HH; Hsueh, JL; Huang, CC | 1 |
| Olsnes, S; Sandvig, K | 1 |
| Boreiko, CJ; Ragan, DL | 1 |
| Carchman, RA; Kessler, FK; Laskin, DL; Laskin, JD; Weinstein, IB | 1 |
| Fukuda, M | 1 |
| Cabot, MC; Welsh, CJ | 1 |
| Mystkowska, ET; Sawicki, W | 1 |
| Bourin, MC; Delescluse, C; Fürstenberger, G; Marks, F; Pruniéras, M | 1 |
| Grotte, G; Larsson, E; Nilsson, K; Odelstad, L; Påhlman, S | 1 |
| Byus, CV; Wu, VS | 1 |
| Baxter, CS; Fish, LA | 1 |
| Kaufmann, WK; Schwartz, JL | 1 |
| Iversen, OH; Paulsen, JE; Schjølberg, A | 1 |
| Hennings, H; Lichti, U; Yuspa, SH | 1 |
| Hallam, T; Schimmel, SD | 1 |
| Blumberg, PM; Nagle, DS | 1 |
| Cole, CF; DeHoogh, DK; Estensen, RD | 1 |
| Marsh, WH; Parsa, I; Sutton, AL | 1 |
| Kennedy, AR; Little, JB; Murphy, G | 1 |
| Novogrodsky, A; Rubin, AL; Schwartz, R; Stenzel, KH | 1 |
| Bohrman, JS; Fischer, SM; Gleason, GL; Slaga, TJ | 1 |
| Fujiwara, Y; Kano, Y; Paul, P; Tatsumi, M | 1 |
| Fibach, E; Gambari, R; Marks, PA; Rifkind, RA | 1 |
| Fischer, SM; Gleason, GL; Mills, GD; Slaga, TJ | 1 |
| Nilsson, K; Sundström, C; Tötterman, TH | 1 |
| Martel, N; Saint-Vincent, L; Yamasaki, H | 1 |
| Boynton, AL; Whitfield, JF | 1 |
| Boreiko, C; Heidelberger, C; Mondal, S; Narayan, KS | 1 |
| Bass, DA; Bond, E; Cousart, S; DeChatelet, LR; Leake, ES; Lineberger, AS; McCall, CE; O'Flaherty, JT | 1 |
| Barrett, JC; Sisskin, EE | 2 |
| Borek, C; Geard, CR; Harisiadis, L; Mason, H; Miller, RC; Napholz, A; Ong, A; Osmak, RS; Perez, N; Rutledge-Freeman, M | 1 |
| McAskill, J; Skinnider, LF | 1 |
| Denison, RC; Tsan, MF | 1 |
| Baxter, CS; Christian, RT; Lankas, GR | 1 |
| Boutwell, RK; Verma, AK; Weekes, RG | 1 |
| Malbon, CC; Strassheim, D | 1 |
| Chen, H; Jassar, BS; Kurenny, DE; Smith, PA | 1 |
| Abello, J; Bosshard, A; Chayvialle, JA; Saifia, S | 1 |
| Juengel, JL; McGuire, WJ; Niswender, GD | 1 |
| Araki, M; Inaba, H; Numai, T | 1 |
| Finnegan, SG; Koenig, E; Lemmon, VP | 1 |
| Ashby, CR; Edwards, E; Wang, RY | 1 |
| Frindt, G; Palmer, LG; Windhager, EE | 1 |
| Barr, SC; Gilmour, RF; Han, W; Pacioretty, LM | 1 |
| Brown, S; Garcia, DE; Hille, B; Mackie, K | 1 |
| Abdullah, LH; Davis, CW; Scott, CE | 1 |
| Hamad, AM; Knox, AJ | 1 |
| Amara, SG; Daniels, GM | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Hubbard, PC; Lummis, SC; Thompson, AJ | 1 |
| Nass, JU; Nuskovski, M; Pleyer, U; Strauss, O; Thieme, H; Wiederholt, M | 1 |
| Arenson, MS; Evans, SC | 1 |
| Dunlop, J; Hediger, MA; Peng, JB; Trotti, D | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Green, M; Mehta, A; Muimo, R; Mwimbi, XK; Sijumbila, G; Treharne, KJ | 1 |
| Jardemark, KE; Liang, X; Ninan, I; Wang, RY | 1 |
| Abramoff, T; Adler-Graschinsky, E; Neuman, I; Orliac, ML; Peroni, RN; Podesta, EJ | 1 |
| Afrasiabi, E; Ahlgren, J; Bergelin, N; Törnquist, K | 1 |
| Ishibashi, M; Ishizu, A; Kato, K; Masuda, S; Nakazawa, D; Nishibata, Y; Sugimoto, A; Tanaka, S; Tomaru, U; Tsujino, I | 1 |
| Kim, JE; Lee, SH; Park, NR | 1 |
21 review(s) available for phorbols and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
Tumor initiation and promotion.
Topics: Animals; Carcinogens; Cocarcinogenesis; DNA Repair; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Hyperplasia; Inflammation; Models, Biological; Mutation; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Synergistic effect of tumor virus transformation and tumor promoter treatment on the production of plasminogen activator by chick embryo fibroblasts.
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Models, Biological; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1978 |
Action of phorbol esters in cell culture: mimicry of transformation, altered differentiation, and effects on cell membranes.
Topics: Adenoviruses, Human; Animals; Arachidonic Acids; Cell Differentiation; Cell Membrane; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Female; HeLa Cells; Humans; Kinetics; Membrane Fluidity; Membrane Lipids; Mice; Phorbols; Prostaglandins; Rats; Tetradecanoylphorbol Acetate | 1979 |
Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Epidermis; In Vitro Techniques; Keratins; Mice; Mitosis; Oncogenes; Papilloma; Peptides; Phenotype; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
Control of cell differentiation and cell transformation in vitro by phorbol 12-myristate 13-acetate and 1 alpha,25-dihydroxyvitamin D3.
Topics: Animals; Calcitriol; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Esterases; Humans; Lyngbya Toxins; Macrophages; Muramidase; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Molecular mechanisms of tumor promotion and multistage carcinogenesis.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Transformation, Neoplastic; ErbB Receptors; Humans; Lyngbya Toxins; Molecular Conformation; Neoplasms; Oncogenes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Interaction of viruses with tumor promotors.
Topics: Animals; Antigens, Viral; Carcinogens; Cell Transformation, Viral; Cells, Cultured; Cloning, Molecular; Deoxyribonucleases; DNA Viruses; DNA-Directed DNA Polymerase; DNA, Viral; Herpesvirus 4, Human; Humans; Oncogenes; Phorbols; Protein Biosynthesis; Retroviridae; Tetradecanoylphorbol Acetate; Virus Activation | 1984 |
Modification of epithelial cell differentiation in vivo by tumor-promoting diterpene esters.
Topics: Alkynes; Animals; Cell Differentiation; Cytoplasmic Granules; Epidermis; Hair; Hyperplasia; Keratins; Phorbol Esters; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1982 |
Observations on the mechanism of skin tumor promotion by phorbol esters.
Topics: Adenosylmethionine Decarboxylase; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Virus induction by tumor promoters.
Topics: Animals; Antigens, Viral; Canavanine; Carcinogens; Cell Line; Cell Transformation, Viral; Diterpenes; DNA, Viral; Enzyme Induction; Herpesviridae; Herpesvirus 4, Human; Humans; Ornithine Decarboxylase; Papillomaviridae; Phorbols; Polyomaviridae; Retroviridae; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Virus Activation | 1982 |
Phorbol ester tumor promoters and lymphocyte proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Lymphocyte Activation; Lymphocytes; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
[Effect of tumor promotor on neoplastic cell transformation].
Topics: Animals; Carcinogens; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Guinea Pigs; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Macrophages; Mice; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Phorbol diesters and cellular differentiation.
Topics: Adipose Tissue; Animals; Cell Differentiation; Chick Embryo; DNA Replication; Fibroblasts; Hematopoietic Stem Cells; Humans; Mice; Muscles; Nervous System; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1984 |
Multistage tumor promotion in skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Humans; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Effects of tumor promoters on arachidonic acid metabolism by cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cell Line; Cycloheximide; Dinoprostone; Growth Substances; Humans; Indomethacin; Lipid Metabolism; Male; Peptide Hydrolases; Phorbols; Prostaglandins; Prostaglandins E; Tetradecanoylphorbol Acetate; Time Factors; Vitamin A; Vitamin E | 1982 |
Potent tumor promoters other than phorbol ester and their significance.
Topics: Alkaloids; Animals; Cell Adhesion; Cell Aggregation; Cell Transformation, Neoplastic; Enzyme Induction; Humans; Isomerism; Lactones; Lyngbya Toxins; Marine Toxins; Mice; Mollusk Venoms; Neoplasms; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.
Topics: Animals; Blood Cells; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Hormones; Humans; Mice; Microtubules; Mitosis; Nucleotides, Cyclic; Phorbol Esters; Phorbols; Phospholipids; Polyamines; Tetradecanoylphorbol Acetate | 1980 |
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2.
Topics: Animals; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Clone Cells; DNA Repair; Models, Biological; Mutagens; Mutation; Neoplasms, Experimental; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
TPA reversibly blocks the differentiation of chick myogenic, chondrogenic, and melanogenic cells.
Topics: Animals; Cartilage; Cell Differentiation; Cell Fusion; Chick Embryo; Fibroblasts; Melanocytes; Muscle Proteins; Muscles; Myofibrils; Neurons; Phorbols; Pigment Epithelium of Eye; Proteoglycans; Tetradecanoylphorbol Acetate | 1982 |
In vitro studies on the mechanism of tumor promoter-mediated inhibition of cell differentiation.
Topics: Acetamides; Animals; Butyrates; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Clone Cells; Diamines; Dimethyl Sulfoxide; Drug Resistance; Globins; Leukemia, Erythroblastic, Acute; Mice; Phorbol Esters; Phorbols; RNA, Messenger; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Specific binding of phorbol ester tumor promoters to mouse tissues and cultured cells.
Topics: Animals; Biological Evolution; Brain; Caenorhabditis elegans Proteins; Calcium; Carcinogens; Carrier Proteins; Cell Membrane; Cells, Cultured; Humans; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Skin; Spleen; Structure-Activity Relationship; Temperature; Tetradecanoylphorbol Acetate; Thermodynamics | 1982 |
1732 other study(ies) available for phorbols and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
Proceedings: Preliminary investigations on the mode of action of the cocarcinogen A1 using bacteria.
Topics: Carcinogens; Escherichia coli; Mutation; Phorbols; Salmonella typhimurium; Tetradecanoylphorbol Acetate | 1975 |
The carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of hairless mice.
Topics: Animals; Carcinoma, Squamous Cell; Fibrosarcoma; Mice; Mice, Nude; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Tumour promoter alone induces neoplastic transformation of fibroblasts from humans genetically predisposed to cancer.
Topics: Animals; Cell Adhesion; Cell Transformation, Neoplastic; Eye; Humans; Mice; Mice, Nude; Multiple Endocrine Neoplasia; Neoplasm Transplantation; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Specificity of response in hamster cells induced to produce plasminogen activator by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Antibodies; Cell Transformation, Neoplastic; Cricetinae; Epitopes; Immunoglobulin G; Lung; Organ Specificity; Phorbols; Plasminogen Activators; Simian virus 40; Tetradecanoylphorbol Acetate | 1978 |
Effects of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate on normal and "preneoplastic" mouse submandibular gland epithelial cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Cell Division; Cells, Cultured; Dimethyl Sulfoxide; Epithelium; Phorbols; Submandibular Gland; Tetradecanoylphorbol Acetate | 1979 |
Systemic two-stage carcinogenesis in the epithelium of the forestomach of mice using 7,12-dimethylbenz(a)anthracene as initiator and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Drug Synergism; Epithelium; Female; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phorbols; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aldehydes; Animals; Carcinoma, Squamous Cell; Decanoates; Drug Synergism; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Phenotypic properties and tumor promotor-induced alterations in rat embryo cells transformed by adenovirus.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoviruses, Human; Animals; Benzopyrenes; Cell Aggregation; Cell Division; Cell Transformation, Neoplastic; Cell Transformation, Viral; Clone Cells; Cocarcinogenesis; Concanavalin A; Embryo, Mammalian; Membrane Proteins; Phenotype; Phorbols; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Drug Synergism; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1979 |
Dynamics of neoplastic development in carcinogen-exposed tracheal mucosa.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cell Adhesion; Cells, Cultured; Epithelium; Female; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Time Factors; Trachea; Tracheal Neoplasms; Transplantation, Isogeneic | 1979 |
Divalent cation effects in the interaction of the tumor promoter phorbol myristate acetate with rat liver plasma membranes.
Topics: Animals; Calcium; Cations, Divalent; Cell Membrane; Egtazic Acid; Female; Fluorescence; Liver; Magnesium; Phorbol Esters; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Phorbol as a possible systemic promoting agent for skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Female; Injections, Intraperitoneal; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.
Topics: Animals; Choline; DNA, Neoplasm; Female; Glycerol; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Phosphatidylcholines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion and the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abortion, Spontaneous; Administration, Oral; Administration, Topical; Animals; Benz(a)Anthracenes; Female; Genital Neoplasms, Female; Injections, Intraperitoneal; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Neoplasms, Multiple Primary; Organ Specificity; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate; Urethane | 1977 |
Interaction of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate with cells in mixed-lymphocyte culture.
Topics: Animals; Cattle; Cell Communication; DNA; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Fluorescence studies on the interaction of the tumor promoter phorbol myristate acetate and related compounds with rat liver plasma membranes.
Topics: Animals; Binding Sites; Cell Membrane; Female; Glucose-6-Phosphatase; Liver; NADH, NADPH Oxidoreductases; Nucleotidases; Phorbol Esters; Phorbols; Phosphoric Diester Hydrolases; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; Succinate Dehydrogenase; Tetradecanoylphorbol Acetate | 1976 |
The effect of the phorbol ester tumor promoters on the basal and catecholamine-stimulated levels of cyclic adenosine 3':5'-monophosphate in mouse skin and epidermis in vivo.
Topics: Animals; Cyclic AMP; Epinephrine; Female; Isoproterenol; Methods; Mice; Phorbols; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Skin; Tetradecanoylphorbol Acetate | 1977 |
Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic GMP from induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo.
Topics: Animals; Carboxy-Lyases; Cyclic AMP; Cyclic GMP; Enzyme Induction; Female; Isoproterenol; Kinetics; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1977 |
Effect of tumor promoters on the activity of cyclic adenosine 3':5'-monophosphate-dependent and -independent protein kinases from mouse epidermis.
Topics: Animals; Caseins; Croton Oil; Cyclic AMP; DNA; Histones; Mice; Phorbols; Protein Kinases; Skin; Tetradecanoylphorbol Acetate | 1977 |
The effect of phorbol diesters on chicken embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Deoxyglucose; Fibroblasts; Mitosis; Models, Biological; Phorbol Esters; Phorbols; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Time Factors; Tumor Virus Infections | 1977 |
Induction of cell division in BALB/c-3T3 cells by phorbol myristate acetate or bovine serum: effects of inhibitors of cyclic AMP phosphodiesterase and Na+-K+-ATPase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Triphosphatases; Animals; Blood Proteins; Bucladesine; Cattle; Cell Division; Cell Line; Dicyclohexylcarbodiimide; Dipyridamole; Fibroblasts; Mice; Mice, Inbred BALB C; Ouabain; Papaverine; Phorbols; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate | 1977 |
Persisting oncogenic herpesvirus induced by the tumour promotor TPA.
Topics: Antigens, Viral; Capsid; Cell Line; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Phorbols; Tetradecanoylphorbol Acetate; Virion; Virus Cultivation; Virus Replication | 1978 |
The effect of phorbol myristate acetate on the metabolism and ultrastructure of human alveolar macrophages.
Topics: Cell Membrane; Glucose; Macrophages; Microvilli; Oxidation-Reduction; Oxygen Consumption; Phorbols; Pulmonary Alveoli; Staphylococcus aureus; Superoxides; Tetradecanoylphorbol Acetate; Vacuoles | 1978 |
Effect of phorbol myristate acetate on cyclic nucleotide levels in mouse epidermis.
Topics: Animals; Cyclic AMP; Cyclic GMP; DNA; Female; Mice; Mice, Inbred ICR; Phorbols; Protein Biosynthesis; RNA; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Effects of multiple phorbol myristate acetate treatments on cyclic nucleotide levels in mouse epidermis.
Topics: Animals; Cyclic AMP; Cyclic GMP; Female; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1978 |
Plasminogen activator in chick fibroblasts: induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester.
Topics: Animals; Cell Transformation, Viral; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Genes, Viral; Kinetics; Phorbols; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1978 |
Metabolism of acetylcholine receptor in chick embryo muscle cells: effects of RSV and PMA.
Topics: Animals; Avian Sarcoma Viruses; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Culture Media; Defective Viruses; Kinetics; Membrane Proteins; Muscles; Phorbols; Receptors, Cholinergic; Tetradecanoylphorbol Acetate | 1978 |
Plasminogen activator in chick embryo muscle cells: induction of enzyme by RSV, PMA and retinoic acid.
Topics: Animals; Avian Sarcoma Viruses; Bucladesine; Cell Differentiation; Cell Fusion; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cholera Toxin; Muscles; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1978 |
Is the product of the src gene a promoter?
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Deoxyglucose; DNA; Genes, Viral; Models, Biological; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Modulation of plasminogen activator synthesis in chick embryo fibroblasts by cyclic nucleotides and phorobol myristate acetate.
Topics: Animals; Avian Sarcoma Viruses; Bucladesine; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cholera Toxin; Cyclic AMP; Fibroblasts; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1979 |
Decrease in collagen production in normal and Rous sarcoma virus-transformed chick embryo fibroblasts induced by phorbol myristate acetate.
Topics: Animals; Avian Sarcoma Viruses; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Collagen; Dimethyl Sulfoxide; Fibroblasts; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoter 12-O-tetradecanoylphorbol-13-acetate is not a prostaglandin E-type agonist.
Topics: Adipose Tissue; Animals; Binding, Competitive; In Vitro Techniques; Male; Phorbols; Prostaglandins E, Synthetic; Rats; Receptors, Cell Surface; Receptors, Prostaglandin; Tetradecanoylphorbol Acetate | 1979 |
Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Colchicine; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vinblastine | 1979 |
Lymphocyte activation by the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Animals; Callitrichinae; Dimethyl Sulfoxide; Dogs; Guinea Pigs; Haplorhini; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Macaca mulatta; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mitogens; Pan troglodytes; Papio; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Tumour promoter TPA enhances transformation of human leukocytes by Epstein-Barr virus.
Topics: Adult; Cell Line; Cell Transformation, Viral; Fetal Blood; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Phorbol ester-induced morphological changes in transformed chick fibroblasts: evidence for direct catalytic involvement of plasminogen activator.
Topics: Animals; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibrinolysin; Fibroblasts; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1979 |
A tumor-promoting phorbol ester inhibits the cyclic AMP response of rat embryo fibroblasts to catecholamines and prostaglandin E1.
Topics: Animals; Catecholamines; Cyclic AMP; Embryo, Mammalian; Female; Fibroblasts; In Vitro Techniques; Phenylephrine; Phorbol Esters; Phorbols; Pregnancy; Prostaglandins E; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Collagenase production by synovial fibroblasts treated with phorbol myristate acetate.
Topics: Animals; Aspirin; Carbon Radioisotopes; Cell Count; Cells, Cultured; Cyclic AMP; DNA; Fibroblasts; Indomethacin; L-Lactate Dehydrogenase; Leucine; Microbial Collagenase; Models, Biological; Phorbols; Prostaglandins E; Protein Binding; Protein Biosynthesis; Rabbits; Radioimmunoassay; Synovial Membrane; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Tritium | 1979 |
Effect of 12-O-tetradecanoyl-phorbol-13-acetate on the replication of Epstein-Barr virus. I. Characterization of viral DNA.
Topics: Antigens, Viral; Capsid; DNA, Viral; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cyclic AMP; Dermatitis, Contact; Diterpenes; Female; Isoproterenol; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Cyclic nucleotide levels in rat embryo fibroblasts treated with tumor-promoting phorbol diester.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Fibroblasts; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Intracellular mediation of lymphokine action: mimicry of migration inhibitory factor (MIF) action by phorbol myristate acetate (PMA) and the ionophore A23187.
Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Cell Migration Inhibition; Cyclic AMP; Fluorescent Antibody Technique; Guinea Pigs; Luminescent Measurements; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Microtubules; Phorbols; Polymers; Superoxides; Tetradecanoylphorbol Acetate; Tubulin; Vinblastine | 1979 |
Effects of the tumor promoter TPA on the induction of DNA synthesis in normal and RSV-transformed rat fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; DNA; DNA Replication; Embryo, Mammalian; Fibroblasts; Kinetics; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Interactions between adenovirus, a tumor promoter, and chemical carcinogens in transformation of rat embryo cell cultures.
Topics: Adenoviruses, Human; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cocarcinogenesis; Phorbols; Polycyclic Compounds; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Heterogeneity of murine erythroleukemia cells with respect to tumor promoter-mediated inhibition of cell differentiation.
Topics: Anesthetics; Animals; Clone Cells; Dexamethasone; Diterpenes; Drug Resistance; Erythropoiesis; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phenotype; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.
Topics: Cell Line; Cell Transformation, Neoplastic; Chromatids; Chromosome Aberrations; Chromosomes; Crossing Over, Genetic; Fluocinolone Acetonide; Leupeptins; Phorbols; Recombination, Genetic; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Tumour-promoting phorbol diester induces substrate-adhesion and growth inhibition in lymphoblastoid cells.
Topics: Animals; Cell Adhesion; Cell Aggregation; Cell Division; Cell Line; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Models, Biological; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.
Topics: Cell Adhesion; Cell Differentiation; Cell Line; Diterpenes; Humans; Leukemia, Myeloid, Acute; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoter-induced adhesion of the DS19 clone of murine erythroleukemia cells.
Topics: Animals; Cell Adhesion; Cell Differentiation; Clone Cells; Cold Temperature; Dactinomycin; Drug Resistance; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of functional and morphological differentiation of cultured mouse myeloid leukemia cells by tumor promoters.
Topics: Animals; Cell Differentiation; Cells, Cultured; Leukemia, Experimental; Leukemia, Myeloid; Mice; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells.
Topics: Cell Differentiation; Cell Division; Cell Line; Globins; Heme; Kinetics; Leukemia, Erythroblastic, Acute; Phorbols; Protein Biosynthesis; RNA, Messenger; Spectrin; Tetradecanoylphorbol Acetate | 1979 |
Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells.
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; DNA Repair; Mice; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1979 |
Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.
Topics: Cell Adhesion; Cell Differentiation; Cell Line; DNA; Humans; Leukemia, Myeloid; Macrophages; Phagocytosis; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1979 |
Phorbol ester induced prostaglandin synthesis and [3H]-TPA metabolism by TPA-sensitive and TPA-resistant Friend erythroleukemia cells.
Topics: Arachidonic Acids; Cell Line; Clone Cells; Kinetics; Leukemia, Erythroblastic, Acute; Phorbol Esters; Phorbols; Prostaglandins E; Prostaglandins F; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Enhancing effect of phorbol esters on induction of differentiation of mouse myeloid leukemia cells by human urinary protein and lipopolysaccharide.
Topics: Animals; Cell Differentiation; Cells, Cultured; Diterpenes; Drug Synergism; Humans; Leukemia, Experimental; Leukemia, Myeloid; Lipopolysaccharides; Mice; Phagocytosis; Phorbol Esters; Phorbols; Proteins; Tetradecanoylphorbol Acetate | 1979 |
Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myeloid; Mice; Phagocytosis; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate | 1979 |
[Differentiation of human normal and leukemic bone marrow and blood cells in tissue culture upon exposure to a tumor promotor].
Topics: Bone Marrow; Cell Differentiation; Cells, Cultured; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Leukocytes; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Macrophage-like cell transformation and CFU(c) fluctuations in normal and leukemic human marrow cultures treated by phorbol diester.
Topics: Bone Marrow; Cell Adhesion; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.
Topics: Animals; Concanavalin A; Dose-Response Relationship, Drug; Erythrocytes; Humans; Immune Adherence Reaction; Lectins; Lymphocyte Activation; Mitogens; Phorbols; Sheep; Stimulation, Chemical; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1977 |
Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells.
Topics: Cycloheximide; Dactinomycin; Epidermal Growth Factor; HeLa Cells; Peptides; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1978 |
Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.
Topics: Binding, Competitive; Cell Membrane; Epidermal Growth Factor; HeLa Cells; Kinetics; Peptides; Phorbol Esters; Phorbols; Receptors, Drug; Tetradecanoylphorbol Acetate | 1978 |
Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-beta-ionone.
Topics: Animals; B-Lymphocytes; Cattle; Choline; Dose-Response Relationship, Drug; Epoxy Compounds; Lymph Nodes; Norisoprenoids; Phorbols; Phospholipids; Terpenes; Tetradecanoylphorbol Acetate | 1978 |
Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate.
Topics: B-Lymphocytes; Cell Line; Deoxy Sugars; Deoxyglucose; Erythrocytes; Glucose; Granulocytes; Humans; Leukocytes; Phagocytosis; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1978 |
Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors.
Topics: Blood; Cells, Cultured; Contact Inhibition; Culture Media; DNA; Drug Synergism; Epidermal Growth Factor; Growth Substances; Insulin; Mitogens; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Lymphocyte stimulation with phorbol myristate acetate in atopic and non-atopic individuals.
Topics: Adolescent; Adult; Aging; Cells, Cultured; Child; Child, Preschool; Concanavalin A; DNA; Female; Humans; Hypersensitivity, Immediate; Infant, Newborn; Lymphocyte Activation; Male; Phorbols; Phytohemagglutinins; Pokeweed Mitogens; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of epidermal growth factor binding to surface receptors by tumor promotors.
Topics: Animals; Binding Sites; Cell Line; DNA; Drug Synergism; Epidermal Growth Factor; Glycolysis; Kinetics; Mice; Peptides; Phorbols; Receptors, Drug; Temperature; Tetradecanoylphorbol Acetate | 1979 |
Binding of epidermal growth factor to primary and permanent cultures of mouse epidermal cells: inhibition by tumor-promoting phorbol esters.
Topics: Animals; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Mice; Neoplasms, Experimental; Peptides; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Signal requirements for T lymphocyte activation. I. Replacement of macrophage function with phorbol myristic acetate.
Topics: Animals; Concanavalin A; Dinitrobenzenes; Female; Guinea Pigs; Kinetics; Lymphocyte Activation; Macrophages; Ovalbumin; Phorbols; Phytohemagglutinins; Rabbits; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1979 |
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors.
Topics: Animals; Blood; Cell Division; Cell Line; DNA; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Growth Substances; Insulin; Mice; Phorbols; Somatomedins; Tetradecanoylphorbol Acetate | 1979 |
The effect of 12-O-tetradecanoyl-phorbol 13-acetate on the ribonuclease activity of circulating human lymphocytes.
Topics: B-Lymphocytes; Humans; Lymphocytes; Phorbols; Phytohemagglutinins; Ribonucleases; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1979 |
Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor.
Topics: Epidermal Growth Factor; HeLa Cells; Humans; Kinetics; Peptides; Phorbols; Receptors, Drug; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoters and epidermal growth factor stimulate anchorage-independent growth of adenovirus-tranformed rat embryo cells.
Topics: Adenoviruses, Human; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dexamethasone; Diterpenes; Embryo, Mammalian; Epidermal Growth Factor; Peptides; Phorbols; Protease Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tretinoin | 1979 |
Retinoids enhance mitogenesis by tumour promotor and polypeptide growth factors.
Topics: Animals; Cell Division; Cell Line; Cricetinae; DNA; DNA Replication; Epidermal Growth Factor; Growth Substances; Insulin; Kinetics; Mice; Mice, Inbred BALB C; Peptides; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Vasopressins | 1979 |
Phorbol myristate acetate: effect of a tumor promoter on insulin release from isolated rat islets of Langerhans.
Topics: Animals; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1978 |
Investigations into the mode of action of the cocarcinogen 12-O-tetradecanoyl-phorbol-13-acetate using auxotrophic bacteria.
Topics: 4-Nitroquinoline-1-oxide; Cell Survival; DNA Repair; Methylnitronitrosoguanidine; Mutation; Phorbols; Salmonella typhimurium; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1977 |
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate | 1977 |
Prostaglandins and skin tumor promotion: inhibition of tumor promoter-induced ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis.
Topics: Animals; Aspirin; Carboxy-Lyases; Cyclooxygenase Inhibitors; Enzyme Induction; Female; Flufenamic Acid; Indomethacin; Mice; Ornithine Decarboxylase; Phorbols; Prostaglandins E; Prostaglandins F; Skin; Tetradecanoylphorbol Acetate | 1977 |
Development of a system for controlled release of benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, and phorbol ester for tumor induction in heterotopic tracheal grafts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bees; Benz(a)Anthracenes; Benzopyrenes; Carbon; Delayed-Action Preparations; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred F344; Solubility; Tetradecanoylphorbol Acetate; Trachea; Tracheal Neoplasms; Transplantation, Isogeneic; Waxes | 1978 |
Quantitative correlation between in vitro and in vivo activities of phorbol esters.
Topics: Animals; Cell Survival; Cells, Cultured; Deoxy Sugars; Deoxyglucose; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Inflammation; Mice; Myristic Acids; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoters induce membrane changes detected by fluorescence polarization.
Topics: Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescence Polarization; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Altered lipid microviscosity in lymphoblastoid cells treated with 12-O-tetradecanoyl phorbol 13-acetate, a tumor promoter.
Topics: Animals; Cell Line; Cells, Cultured; Cholesterol; Humans; Kinetics; Leukemia; Leukemia L1210; Lipid Metabolism; Liposomes; Lymphocytes; Mice; Phorbols; Phospholipids; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Viscosity | 1979 |
Inhibition of phorbol ester-accelerated amino acid transport in bovine lymphocytes.
Topics: Aminoisobutyric Acids; Animals; Biological Transport, Active; Cattle; Cycloheximide; Dactinomycin; In Vitro Techniques; Lymphocytes; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1979 |
Stimulation of differentiated functions in human melanoma cells by tumor-promoting agents and dimethyl sulfoxide.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Gangliosides; Humans; Melanins; Melanoma; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
An improved nitroblue tetrazolium test using phorbol myristate acetate-coated coverslips.
Topics: Chemical Phenomena; Chemistry; Granulomatous Disease, Chronic; Heterozygote; Humans; Neutrophils; Nitroblue Tetrazolium; Phorbols; Tetradecanoylphorbol Acetate; Tetrazolium Salts | 1979 |
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate stimulates lactate production in BALB/c 3T3 preadipose cells.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cell Line; Kinetics; Lactates; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate.
Topics: Cytochromes; Humans; Neutrophils; Oxidation-Reduction; Phorbols; Spectrophotometry; Tetradecanoylphorbol Acetate | 1979 |
The effect of phorbol myristate acetate on human lymphocytes. An ultrastructural study.
Topics: Agglutination; Cytoplasm; Endoplasmic Reticulum; Golgi Apparatus; Humans; Lymphocyte Activation; Lymphocytes; Lysosomes; Phorbols; Phytohemagglutinins; Ribosomes; Tetradecanoylphorbol Acetate | 1979 |
Membrane effects of tumor promoters: stimulation of sugar uptake in mammalian cell cultures.
Topics: Biological Transport, Active; Cell Line; Deoxy Sugars; Deoxyglucose; HeLa Cells; Kinetics; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate elevates serum progesterone levels.
Topics: Animals; Chickens; Estradiol; Female; Ovalbumin; Oviducts; Phorbols; Progesterone; Tetradecanoylphorbol Acetate | 1979 |
Studies on the activity of phorbol myrystate acetate on the human polymorphonuclear leukocytes.
Topics: Adult; Humans; Neutrophils; Nitroblue Tetrazolium; Nucleotides, Cyclic; Oxidation-Reduction; Phenylbutazone; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1979 |
Morphological & biochemical studies on separated constituents of mouse skin treated with phorbol myristate acetate.
Topics: Animals; DNA; Female; Methylcholanthrene; Mice; Phorbols; Proteins; RNA; Skin; Tetradecanoylphorbol Acetate | 1979 |
Epidermal prostaglandins after topical application of a tumor promotor.
Topics: Administration, Topical; Animals; Male; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins E; Prostaglandins F; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Effect of phorbol ester tumor promoters on the expression of melanogenesis in B-16 melanoma cells.
Topics: Animals; Cell Differentiation; Clone Cells; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of phorbol myristate acetate and phytohemagglutinin stimulation of human lymphocytes by retinol.
Topics: Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Vitamin A | 1979 |
Effects of phorbol ester tumor promoters in platelet aggregation and platelet production of cyclooxygenase products.
Topics: Animals; Arachidonic Acids; Biological Assay; Blood Platelets; In Vitro Techniques; Indomethacin; Phorbol Esters; Phorbols; Platelet Aggregation; Prostaglandin Endoperoxides; Rabbits; Tetradecanoylphorbol Acetate; Thromboxane A2; Vasoconstriction | 1979 |
An assay procedure for the comparative irritancy testing of esters in the tigliane and daphnane series.
Topics: Animals; Chemical Phenomena; Chemistry; Diterpenes; Esters; Female; Inflammation; Irritants; Mice; Phorbols; Plants, Toxic; Skin; Tetradecanoylphorbol Acetate; Toxins, Biological | 1979 |
The effect of a tumor promotor, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), on sister-chromatid exchange formation in cultured Chinese hamster cells.
Topics: Animals; Cell Line; Chromatids; Chromosome Aberrations; Chromosomes; Cricetinae; Crossing Over, Genetic; Drug Evaluation, Preclinical; Female; Lung; Mutagens; Ovary; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
DNA repair and malignant transformation: effect of X irradiation, 12-O-tetradecanoyl-phorbol-13-acetate, and protease inhibitors on transformation and sister-chromatid exchanges in mouse 10T 1/2 cells.
Topics: Animals; Antipain; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA Repair; Dose-Response Relationship, Radiation; In Vitro Techniques; Leupeptins; Mice; Phorbols; Protease Inhibitors; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; X-Rays | 1979 |
Tumour promoter induces anchorage independence irreversibly.
Topics: Animals; Antigens, Surface; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Mice; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Tumour promoters enhance anchorage-independent growth of adenovirus-transformed cells without altering the integration pattern of viral sequences.
Topics: Adenoviruses, Human; Animals; Cell Adhesion; Cell Division; Cell Transformation, Viral; DNA, Viral; Genes, Viral; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.
Topics: Animals; Cell Communication; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thioguanine | 1979 |
Ornithine decarboxylase activity and DNA synthesis after treatment of cells in culture with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Cricetinae; Culture Media; DNA; Embryo, Mammalian; Enzyme Induction; Fibroblasts; Humans; Mice; Ornithine Decarboxylase; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1979 |
Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters.
Topics: Animals; Dose-Response Relationship, Drug; Female; Kinetics; Mice; Phorbol Esters; Phorbols; Prostaglandins E; Prostaglandins F; Skin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Suppression of natural antitumour defence mechanisms by phorbol esters.
Topics: Animals; Cytotoxicity, Immunologic; Depression, Chemical; Immunity, Innate; Killer Cells, Natural; Macrophages; Mice; Neoplasms, Experimental; Phorbols; Rats; Spleen; Tetradecanoylphorbol Acetate | 1979 |
Differential response of myofibrils and 10-nm filaments to a cocarcinogen.
Topics: Animals; Carcinogens; Chick Embryo; Cocarcinogenesis; Myofibrils; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Phorbol myristate acetate-induced release of granule enzymes from human neutrophils: inhibition by the calcium antagonist, 8-(N,N-diethylamino)-octyl 3,4,5-trimethoxybenzoate hydrochloride.
Topics: Calcium; Cytoplasmic Granules; Gallic Acid; Glucuronidase; Humans; Kinetics; L-Lactate Dehydrogenase; Muramidase; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells.
Topics: Animals; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Mice; Phorbol Esters; Phorbols; Skin; Tetradecanoylphorbol Acetate; Uridine | 1979 |
Neogenesis of functional hair follicles in adult mouse skin selectively induced by tumour-promoting phorbol esters.
Topics: Animals; Female; Hair; Mice; Phorbol Esters; Phorbols; Skin; Skin Physiological Phenomena; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Synergistic stimulation of early events and DNA synthesis by phorbol esters, polypeptide growth factors, and retinoids in cultured fibroblasts.
Topics: Animals; Cell Line; Deoxyglucose; DNA; Fibroblasts; Growth Substances; Mice; Mitogens; Peptides; Phorbols; Potassium; Sodium; Tetradecanoylphorbol Acetate; Tretinoin; Uridine; Vasopressins | 1979 |
Inhibition of phorbol ester-induced polyamine accumulation in mouse epidermis by anti-inflammatory steroid.
Topics: Animals; Carboxy-Lyases; Female; Fluocinolone Acetonide; Mice; Ornithine Decarboxylase; Phorbols; Polyamines; Putrescine; Skin; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1979 |
Effects of phorbol 12-myristate 13-acetate and cortisol interaction on steroid-binding capacity in the rat.
Topics: Animals; Cytosol; Dexamethasone; Female; Hydrocortisone; In Vitro Techniques; Liver; Phorbols; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Tetradecanoylphorbol Acetate; Transcortin | 1979 |
Effects of tumor-promoting phorbol diesters on hamster cells in culture.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA; Embryo, Mammalian; Enzyme Induction; Inactivation, Metabolic; Mesocricetus; Mice; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1979 |
Failure of tumor promoter 12-O-tetradecanoylphorbol-13-acetate to displace estradiol from its specific receptor.
Topics: Animals; Carcinogens; Cell Line; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Phorbols; Rats; Receptors, Estrogen; Tetradecanoylphorbol Acetate | 1979 |
5,6-epoxyretinoic acid opposes the effects of 12-O-tetradecanoylphorbol-13-acetate in bovine lymphocytes.
Topics: Animals; Biotransformation; Cattle; Choline; Epoxy Compounds; Lymphocytes; Membrane Lipids; Phorbols; Phospholipids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1979 |
Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Fibroblasts; Methylcholanthrene; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Thymidine | 1977 |
Effects of a tumor-promoting agent on chondrogenesis.
Topics: Animals; Carcinogens; Cartilage; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chickens; Phorbols; Proteoglycans; Tetradecanoylphorbol Acetate | 1977 |
Stimulation of choline incorporation in cell cultures by phorbol derivatives and its correlation with their irritant and tumor-promoting activity.
Topics: Animals; Cells, Cultured; Choline; Colchicine; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mice; Phorbols; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone | 1979 |
Tumor promoters induce changes in the chick embryo fibroblast cytoskeleton.
Topics: Actins; Animals; Cells, Cultured; Chick Embryo; Cocarcinogenesis; Cytoskeleton; Phorbols; Plasminogen; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1979 |
Stimulation of secretion of disaturated phosphatidylcholine from isolated alveolar type II cells by 12-O-tetradecanoyl-13-phorbol acetate.
Topics: Animals; Cells, Cultured; Colchicine; Cold Temperature; Dogs; In Vitro Techniques; L-Lactate Dehydrogenase; Phorbols; Phosphatidylcholines; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Vinblastine | 1978 |
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Radiation; In Vitro Techniques; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Effects of tumor promoters and steroidal anti-inflammatory agents on skin of newborn mice in vivo and in vitro.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dexamethasone; DNA; Enzyme Induction; Female; Fluocinolone Acetonide; Mice; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Pregnancy; Skin; Tetradecanoylphorbol Acetate | 1978 |
Retinoic acid inhibition of the comitogenic action of mezerein and phorbol esters in bovine lymphocytes.
Topics: Animals; Cattle; Diterpenes; DNA; Drug Synergism; In Vitro Techniques; Lectins; Lymphocyte Activation; Lymphocytes; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1978 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).
Topics: Animals; Carboxy-Lyases; Drug Evaluation, Preclinical; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin A | 1978 |
Enhancement by Corynebacterium parvum of the normal and tumor tissue response to hyperthermia.
Topics: Animals; Foot; Hyperthermia, Induced; Mice; Mice, Inbred C3H; Phorbols; Propionibacterium acnes; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Effect of aging in two-stage carcinogenesis on mouse skin with phorbol myristate acetate as promoting agent.
Topics: Aging; Animals; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1978 |
Chemical ionization mass spectrometry of the tumor promoter related 4aalpha-phorbol esters.
Topics: Mass Spectrometry; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Tumor-promoting activity of 2,3-dihydrophorbol myristate acetate and phorbolol myristate acetate in mouse skin.
Topics: Animals; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion.
Topics: Cells, Cultured; Diterpenes; HeLa Cells; Phorbol Esters; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1978 |
Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells.
Topics: Bromodeoxyuridine; Cell Differentiation; Cell Line; Diterpenes; Dose-Response Relationship, Drug; Neuroblastoma; Neurons; Papaverine; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate | 1978 |
Stimulation of 86Rb+ and 32Pi movements in 3T3 cells by prostaglandins and phorbol esters.
Topics: Biological Transport, Active; Cell Cycle; Cell Line; Ouabain; Phorbols; Phosphates; Prostaglandins E; Prostaglandins F; Rubidium; Tetradecanoylphorbol Acetate | 1978 |
Fine structural alterations induced in erythocytes by phorbol myristate acetate.
Topics: Cell Membrane; Dose-Response Relationship, Drug; Erythrocytes; Humans; Phorbols; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Induction of epidermal cell proliferation by a tumour promoter in vitamin B6-deficient mice.
Topics: Animals; Female; Mice; Mitosis; Phorbols; Skin; Tetradecanoylphorbol Acetate; Vitamin B 6 Deficiency; Vitamin B Deficiency | 1978 |
Stimulation of prostaglandin synthesis by tumor-promoting phorbol-12, 13-diesters in canine kidney (MDCK) cells. Cycloheximide inhibits the stimulated prostaglandin synthesis, deacylation of lipids, and morphological changes.
Topics: Cell Line; Cycloheximide; Hydrocortisone; Indomethacin; Kidney; Lipid Metabolism; Phorbol Esters; Phorbols; Prostaglandins; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Metabolic conversion of 12-O-tetradecanoylphorbol-13-acetate in adult and newborn mouse skin and mouse liver microsomes.
Topics: Animals; Animals, Newborn; Esterases; Female; In Vitro Techniques; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Microsomes, Liver; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1978 |
Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts.
Topics: Animals; Cartilage; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Fibroblasts; Mitogens; Phorbols; Proteoglycans; Tetradecanoylphorbol Acetate | 1978 |
Metabolism of tritium-labeled 12-O-tetradecanoylphorbol-13-acetate by cells in culture.
Topics: Animals; Cells, Cultured; Chloroform; Chromatography, Thin Layer; Cricetinae; Fibroblasts; Humans; Phorbol Esters; Phorbols; Species Specificity; Tetradecanoylphorbol Acetate; Tritium | 1978 |
A cell culture bioassay to analyze metabolism of phorbol diester tumor promoters.
Topics: Animals; Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chromatography, Thin Layer; Cricetinae; Fibroblasts; Humans; Mice; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Rats; Species Specificity; Tetradecanoylphorbol Acetate | 1978 |
Effects of retinoic acid and juvenile hormone on the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carboxy-Lyases; Cattle; Drug Interactions; Enzyme Induction; In Vitro Techniques; Juvenile Hormones; Lectins; Lymphocyte Activation; Lymphocytes; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1978 |
Rapid stimulation of phospholipid metabolism in bovine lymphocytes by tumor-promoting phorbol esters.
Topics: Cells, Cultured; Choline; Cycloheximide; Cytochalasin B; Dactinomycin; Drug Interactions; Lectins; Lymphocyte Activation; Lymphocytes; Phorbol Esters; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate; Tretinoin | 1978 |
Non-phorbol mouse skin tumor promoters do not mimic phorbol myristate acetate in its effects on chick embryo fibroblasts.
Topics: Acetates; Animals; Anthralin; Cantharidin; Carcinogens; Cell Membrane; Chick Embryo; Cytochalasin B; Deoxyglucose; Fibroblasts; Glycoproteins; Lauric Acids; Neoplasms, Experimental; Oleic Acids; Palmitic Acids; Phenols; Phorbols; Skin Neoplasms; Stearic Acids; Tetradecanoylphorbol Acetate | 1978 |
Opposing effects of tumor promoters on erythroid differentiation.
Topics: Acetamides; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Hypoxanthines; Phorbols; Rauscher Virus; Tetradecanoylphorbol Acetate | 1978 |
Establishment of epithelial cell lines following exposure of cultured tracheal epithelium to 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epithelium; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors; Trachea | 1978 |
Effect of phorbol myristate acetate on cellular metabolism and lysozyme release from alveolar macrophages and polymorphonuclear leukocytes.
Topics: Animals; Macrophages; Muramidase; Neutrophils; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1978 |
Effect of tumor promoters on the response of cultured embryonic chick ganglia to nerve growth factor.
Topics: Animals; Binding Sites; Cell Survival; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Ganglia; Ganglia, Autonomic; Ganglia, Spinal; Kinetics; Nerve Growth Factors; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Stimulation by carcinogens and promoters of prostaglandin production by dog kidney (MDCK) cells in culture.
Topics: Animals; Arachidonic Acids; Carcinogens; Cell Differentiation; Cells, Cultured; Dogs; Kidney; Lipid Metabolism; Phorbol Esters; Phorbols; Polycyclic Compounds; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1978 |
Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D.
Topics: Animals; Cell Line; Chromatography, DEAE-Cellulose; Kinetics; Macrophages; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Comparison of the metabolism of alveolar macrophages from humans, rats, and rabbits: phorbol myristate acetate.
Topics: Animals; Bacteria; Glycolysis; Humans; Luminescent Measurements; Lung; Macrophages; Oxygen Consumption; Phorbols; Rabbits; Rats; Smoking; Species Specificity; Tetradecanoylphorbol Acetate | 1978 |
Retinoids as well as tumour promoters enhance deacylation of cellular lipids and prostaglandin production in MDCK cells.
Topics: Cell Line; Lipid Metabolism; Phorbols; Prostaglandins; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1978 |
Indomethacin inhibition of cell proliferation induced by the phorbolester TPA is reversed by prostaglandin E2 in mouse epidermis in vivo.
Topics: Animals; Cell Division; DNA; Female; Indomethacin; Kinetics; Mice; Phorbols; Prostaglandins E; Skin; Tetradecanoylphorbol Acetate | 1978 |
Stimulation of the synthesis of the H1 and H3 histone fractions of mouse epidermis by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Female; Histones; Lysine; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1978 |
Bactericidal capacity of phorbol myristate acetate-treated human polymorphonuclear leukocytes.
Topics: Cytoplasmic Granules; Exocytosis; Hexosephosphates; Neutrophils; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Tumor promoting phorbol diesters stimulate release of radioactivity from [3H]-arachidonic acid labeled- but not [14C]linoleic acid labeled-cells. Indomethacin inhibits the stimulated release from [3H] arachidonate labeled cells.
Topics: Animals; Arachidonic Acids; Cell Line; Dogs; Indomethacin; Linoleic Acids; Phorbol Esters; Phorbols; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1978 |
Disturbances of early sea-urchin development by the tumor promoter TPA (phorbol ester).
Topics: Animals; Cell Division; Embryo, Nonmammalian; Female; Phorbols; Sea Urchins; Tetradecanoylphorbol Acetate | 1978 |
The effect of phorbol myristate acetate on amylase secretion and 45Ca efflux from rat pancreas [proceedings].
Topics: Amylases; Animals; Biological Transport; Calcium; In Vitro Techniques; Pancreas; Phorbols; Rats; Secretory Rate; Tetradecanoylphorbol Acetate | 1978 |
Two-stage malignant transformation in hamster embryo cells.
Topics: Agar; Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Cricetinae; Methylcholanthrene; Neoplasm Transplantation; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1979 |
Inhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred ICR; Mustard Compounds; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1976 |
Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Drug Administration Schedule; Methylcholanthrene; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1976 |
Epidermal cell proliferation and promoting ability of phorbol esters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Edema; Female; Hyperplasia; Inflammation; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Drug Synergism; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Phorbols; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1976 |
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; DNA Repair; Drug Resistance; Mutation; Neoplasms, Experimental; Ouabain; Phorbols; Tetradecanoylphorbol Acetate; Thioguanine; Time Factors; Ultraviolet Rays | 1977 |
Histone phosphorylation and synthesis of DNA and RNA during phases of proliferation and differentiation induced in mouse epidermis by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; DNA; DNA, Neoplasm; Female; Histones; Mice; Neoplasms, Experimental; Phorbols; Phosphorus; RNA; RNA, Neoplasm; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1977 |
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.
Topics: Animals; Anti-Inflammatory Agents; Cell Division; Cells, Cultured; Depression, Chemical; DNA; Female; Fluocinolone Acetonide; Fluocinonide; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Plasminogen Activators; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1977 |
Effect of a tumour promoter on myogenesis.
Topics: Actomyosin; Cell Differentiation; Cell Division; Cell Fusion; Cells, Cultured; Culture Media; DNA; Molecular Weight; Muscles; Myosins; Phorbols; Tetradecanoylphorbol Acetate | 1977 |
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Administration Schedule; Enzyme Induction; Female; In Vitro Techniques; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1977 |
Induction of ornithine decarboxylase activity in epidermis by a tumor promoter: decreased response in mice maintained on a vitamin B6-deficient diet.
Topics: Animals; Carboxy-Lyases; Enzyme Induction; Female; Kinetics; Mice; Ornithine Decarboxylase; Phorbols; Pyridoxal Phosphate; Pyridoxine; Skin; Tetradecanoylphorbol Acetate; Trypsin; Vitamin B 6 Deficiency | 1977 |
Qualitative and quantitative separation of a series of phorbol-ester tumor promoters by high-pressure liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Mice; Phorbol Esters; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1977 |
Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters.
Topics: Carboxy-Lyases; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Enzyme Induction; Ornithine Decarboxylase; Phorbols; Putrescine; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1977 |
Synthesis of 4aalpha-phorbol 9-myristate 9a-acetate and related esters.
Topics: Phorbols; Stereoisomerism; Tetradecanoylphorbol Acetate | 1977 |
Stimulation of the synthesis of mouse epidermal histones by tumor-promoting agents.
Topics: Animals; Cycloheximide; DNA; Drug Interactions; Female; Histones; Hydroxyurea; Lysine; Mice; Phorbols; Protein Biosynthesis; Skin; Tetradecanoylphorbol Acetate | 1977 |
The synthesis of specific proteins in adult mouse epidermis during phases of proliferation and differentiation induced by the tumor promoter TPA, and in basal and differentiating layers of neonatal mouse epidermis.
Topics: Animals; Cell Differentiation; Cell Division; Electrophoresis, Polyacrylamide Gel; Female; Keratins; Mice; Models, Biological; Phorbols; Protein Biosynthesis; Protein Precursors; Proteins; Skin; Tetradecanoylphorbol Acetate | 1976 |
The effect of colchicine on the induction of ornithine decarboxylase by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Carboxy-Lyases; Colchicine; Cytochalasin B; Demecolcine; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors; Vinblastine; Vincristine | 1976 |
Further characterization of NADPH oxidase activity of human polymorphonuclear leukocytes.
Topics: Humans; Manganese; NADH, NADPH Oxidoreductases; Neutrophils; Oxidation-Reduction; Phagocytosis; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Xanthine Oxidase | 1976 |
Stimulated DNA synthesis in mouse epidermal cell cultures treated with 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Fibroblasts; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mitosis; Phorbol Esters; Phorbols; Skin; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1976 |
Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Phorbols; Precancerous Conditions; Rhabdomyosarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
The structural relationship of phorbol and cortisol: a possible mechanism for the tumor promoting activity of phorbol.
Topics: Hydrocortisone; Models, Molecular; Neoplasms; Phorbols; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate | 1976 |
Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts.
Topics: Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Fibroblasts; Membrane Proteins; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Nonspecific inhibition of DNA repair synthesis by tumor promoters in human diploid fibroblasts damaged with N-acetoxy-2-acetylaminofluorene.
Topics: Acetoxyacetylaminofluorene; Anthralin; Anthraquinones; Carcinogens; Cell Line; Croton Oil; Depression, Chemical; Diploidy; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; Fluorenes; Humans; Nitrophenols; Phenols; Phorbols; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1975 |
The identification of phorbolol myristate acetate as a new metabolite of phorbol myristate acetate in mouse skin.
Topics: Animals; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Mitosis; Phorbols; Skin; Stimulation, Chemical; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine | 1975 |
Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate.
Topics: Complement C5; Cytochalasin B; Glucuronidase; Humans; Lysosomes; Microtubules; Muramidase; Neutrophils; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Zymosan | 1975 |
Decrease of epidermal histidase activity by tumor-promoting phorbol esters.
Topics: Ammonia-Lyases; Animals; Benz(a)Anthracenes; Carcinogens; Depression, Chemical; Histidine Ammonia-Lyase; Male; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Polysorbates; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1975 |
Nonspecific inhibition of DNA repair by promoting and nonpromoting phorbol esters.
Topics: Acetoxyacetylaminofluorene; DNA Repair; DNA Replication; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1975 |
Calcium-dependent stimulation of BALB/c 3T3 mouse cell DNA synthesis by a tumor-promoting phorbol ester (PMA).
Topics: Calcium; Cell Line; DNA; Ethanol; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1976 |
Tumour promotor induces plasminogen activator.
Topics: Cell Transformation, Neoplastic; Fibroblasts; HeLa Cells; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1976 |
Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes.
Topics: Amino Acids; Deoxyglucose; Glucose; Humans; Luminescent Measurements; Neutrophils; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Zymosan | 1976 |
Identification of Na(+)-H+ exchange in human normal and cystic fibrotic ciliated airway epithelium.
Topics: Adolescent; Adult; Amiloride; Carrier Proteins; Cells, Cultured; Cilia; Cystic Fibrosis; Epithelium; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Nasal Mucosa; Nasal Polyps; Phorbols; Potassium; Reference Values; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1992 |
Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes.
Topics: Animals; Bombesin; Cells, Cultured; Cycloheximide; Female; Fetus; Insulin; Kinetics; Liver; Male; Phorbols; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Pregnancy; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Topics: Alkaloids; Antigens, Neoplasm; Biomarkers, Tumor; Calcimycin; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Humans; Male; Nandrolone; Phorbols; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Staurosporine; Testosterone Congeners; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of IK,Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Ganglia; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
Topics: Animals; Calcimycin; Calmodulin; Carbachol; Cholera Toxin; Gastric Mucosa; Guinea Pigs; Imidazoles; In Vitro Techniques; Kinetics; Male; Phorbol 12,13-Dibutyrate; Phorbols; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C-linked inactivation of the interleukin-1 receptor in a human transformed B-cell line.
Topics: B-Lymphocytes; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Cell Membrane; Enzyme Activation; Humans; Interleukin-1; Kinetics; Lymphoma; Phorbol 12,13-Dibutyrate; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Receptors, Interleukin-1; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Protein kinase C plays an inhibitory role in interleukin 3- and interleukin 4-mediated mast cell proliferation.
Topics: Animals; Cell Division; Cell Membrane; Cells, Cultured; Cytosol; DNA Replication; Inositol; Inositol Phosphates; Interleukin-3; Interleukin-4; Kinetics; Male; Mast Cells; Mice; Mice, Inbred BALB C; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine | 1990 |
Effect of phorbol esters on the susceptibility of a glioma cell line to lymphokine-activated killer cell activity.
Topics: Cell Division; Glioma; Humans; Killer Cells, Lymphokine-Activated; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1990 |
Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts.
Topics: Aprotinin; Basement Membrane; Cell Division; Culture Media; Cysteine; Edetic Acid; Endopeptidases; Ethylmaleimide; Fibroblasts; Humans; Metalloendopeptidases; Microbial Collagenase; Phorbols; Procollagen; Skin; Tetradecanoylphorbol Acetate; Time Factors; Trypsin | 1985 |
Redistribution of phospholipid/calcium-dependent protein kinase and altered phosphorylation of its soluble and particulate substrate proteins in phorbol ester-treated rat pancreatic acini.
Topics: Amylases; Animals; In Vitro Techniques; Male; Pancreas; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Proteins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Responses of human cervical keratinocytes in vitro to tumour promoters and diethylstilboestrol.
Topics: Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cervix Uteri; Clone Cells; Diethylstilbestrol; Diterpenes; Female; Humans; Keratins; Kinetics; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
Effect of TPA on ion fluxes and DNA synthesis in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Biological Transport; Cell Line; Chlorides; DNA; Epidermal Growth Factor; Ion Channels; Muscle, Smooth, Vascular; Phorbols; Potassium; Rats; Sodium; Tetradecanoylphorbol Acetate | 1985 |
Hydrocortisone inhibits phorbol ester stimulated release of histamine and arachidonic acid from rat mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Histamine Release; Hydrocortisone; Mast Cells; Phorbols; Rats; Somatostatin; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting phorbol esters induce angiogenesis in vitro.
Topics: Animals; Capillaries; Cattle; Cell Count; Cell Line; Cell Movement; Collagen; DNA; Endothelium; Microbial Collagenase; Neovascularization, Pathologic; Phenanthrolines; Phorbol Esters; Phorbols; Plasminogen Activators; Protease Inhibitors; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1985 |
Effects of a teratogen on [3H]uridine nucleotide transfer between human embryonal cells and on gap junctions.
Topics: Cell Communication; Cells, Cultured; Embryo, Mammalian; Freeze Fracturing; Humans; Intercellular Junctions; Microscopy, Electron; Morphogenesis; Phorbols; RNA; Tetradecanoylphorbol Acetate; Uridine | 1985 |
Calcium ionophore plus phorbol ester can substitute for antigen in the induction of cytolytic T lymphocytes from specifically primed precursors.
Topics: Animals; Antigens; Antigens, Differentiation, T-Lymphocyte; Antigens, Ly; Antigens, Surface; Cell Separation; Cytotoxicity, Immunologic; Epitopes; Ethers; Ionomycin; Ionophores; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phorbols; Stem Cells; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1985 |
Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon.
Topics: Animals; Bone Marrow Cells; Calcimycin; Cytotoxicity, Immunologic; Diglycerides; Dose-Response Relationship, Drug; Interferons; Lipopolysaccharides; Macrophages; Male; Mice; Neoplasms, Experimental; Phorbols; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1985 |
Histamine release induced by histone and phorbol ester from rat peritoneal mast cells.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Female; Histamine Release; Histones; In Vitro Techniques; Male; Mast Cells; Peptide Fragments; Peritoneal Cavity; Phorbols; Rats; Rats, Inbred Strains; Substance P; Tetradecanoylphorbol Acetate | 1985 |
Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carcinoma; Female; Fluocinolone Acetonide; Gene Expression Regulation; Keratins; Mice; Molecular Weight; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Thyroid cell responses to thyrotropin and 12-O-tetradecanoyl-phorbol-13-acetate: translocation of protein kinase C and phosphorylation of thyroid cell polypeptide substrates.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Peptides; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors | 1985 |
Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Histamine Release; Inositol; Isoquinolines; Mast Cells; p-Methoxy-N-methylphenethylamine; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester enhances deoxynucleoside incorporation while inhibiting proliferation of K-562 cells.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line; Deoxyribonucleosides; DNA; Flow Cytometry; Humans; Interphase; Phorbols; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1985 |
[Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels].
Topics: Blood Platelets; Calcium; Enzyme Activation; Fluorescent Dyes; Humans; In Vitro Techniques; Ion Channels; Kinetics; Phorbols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate; Thrombin | 1985 |
Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Insulin; Insulin Secretion; Ion Channels; Membrane Potentials; Pheochromocytoma; Phorbols; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium; Endotoxins; Humans; Interferon-gamma; Interleukin-1; Interleukin-2; Kinetics; Neutrophils; Phorbols; Protein Biosynthesis; RNA; Temperature; Tetradecanoylphorbol Acetate; Umbilical Veins | 1986 |
Tyrosine phosphorylation of platelet protein induced by phorbol ester.
Topics: Animals; Blood Platelets; Enzyme Activation; Kinetics; Microscopy, Electron; Microscopy, Electron, Scanning; Molecular Weight; Phorbols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
T cell stimulation via the erythrocyte receptor. Synergism between monoclonal antibodies and phorbol myristate acetate without changes of free cytoplasmic Ca++ levels.
Topics: Antibodies, Monoclonal; Antigen-Antibody Complex; Calcium; Carrier Proteins; CD2 Antigens; Cytoplasm; Epitopes; Humans; Lymphocyte Activation; Phorbols; Receptors, Antigen, T-Cell; Receptors, Immunologic; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester stimulates amylase secretion from rat parotid cells.
Topics: Amylases; Animals; Bucladesine; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Exocytosis; Parotid Gland; Phorbols; Protein Kinase C; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunologic Techniques; Immunosorbent Techniques; Lymphoma; Mice; Molecular Weight; Phorbols; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Activation of myelin protein kinase by diacylglycerol and 4 beta-phorbol 12-myristate 13-acetate.
Topics: Animals; Diglycerides; Enzyme Activation; Glycerides; Myelin Basic Protein; Myelin Sheath; Phorbols; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Rats; Tetradecanoylphorbol Acetate | 1986 |
Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect.
Topics: Animals; Calcium; Cell Communication; Cell Membrane Permeability; Clone Cells; Diglycerides; Gallic Acid; Glycerides; Imidazoles; Intercellular Junctions; Ion Channels; Isoquinolines; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol myristate acetate stimulates RNA and casein synthesis in cultured mouse mammary gland tissues.
Topics: Animals; Caseins; Cells, Cultured; Dose-Response Relationship, Drug; Female; Mammary Glands, Animal; Mice; Ornithine Decarboxylase; Phorbols; Pregnancy; Prolactin; Protein Kinase C; RNA; Spermidine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1986 |
Transformation of human keratinocytes by SV40 virus alters their response to the tumor promoter TPA.
Topics: Actins; Cell Line; Cell Transformation, Viral; Cytoskeleton; Desmosomes; Fibronectins; Fluorescent Antibody Technique; Humans; Keratins; Phorbols; Simian virus 40; Skin; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters and calcium ionophore can prime murine peritoneal macrophages for tumor cell destruction.
Topics: Animals; Calcimycin; Calcium; Cytotoxicity, Immunologic; Egtazic Acid; Interferon-gamma; Ion Channels; Macrophage Activation; Mast-Cell Sarcoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Peritoneal Cavity; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Viral; Diglycerides; Mice; Molecular Weight; Mutation; Oncogene Proteins, Viral; Phorbols; Phosphorylation; Polyomavirus; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Ca2+-, phorbol ester-, and cAMP-stimulated enzyme secretion from permeabilized rat pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcium; Carbachol; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytoplasmic Granules; Digitonin; Egtazic Acid; Pancreas; Phorbols; Rats; Rats, Inbred Strains; Saponins; Spermine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1986 |
Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters.
Topics: Animals; Carcinogens; Drug Synergism; Histamine Release; In Vitro Techniques; Kinetics; Male; Mast Cells; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis.
Topics: Animals; Cattle; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Dogs; Epithelium; Female; Intercellular Junctions; Keratins; Kidney; Mammary Glands, Animal; Membrane Proteins; Phorbols; Phosphorylation; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Vimentin | 1986 |
Induction of endogenous xenotropic retrovirus expression by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Line; Cell Transformation, Viral; DNA; Dose-Response Relationship, Drug; Kirsten murine sarcoma virus; Mice; Neutralization Tests; Phorbols; Protein Biosynthesis; Retroviridae; Retroviridae Proteins; RNA; Tetradecanoylphorbol Acetate; Virus Activation | 1986 |
CD 1-8 antigens on human diphtheria toxoid T lymphocyte clones: expression and modulation by TPA, sodium butyrate, and 5-azacytidine.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Azacitidine; Butyrates; Butyric Acid; Clone Cells; Diphtheria Toxoid; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Kinetics; Lymphocyte Activation; Phorbols; T-Lymphocytes, Helper-Inducer; Tetradecanoylphorbol Acetate | 1986 |
Enhancement of the expression of a rat neutrophil-specific cell surface antigen by activation with phorbol myristate acetate and concanavalin A.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens, Surface; Binding Sites, Antibody; Concanavalin A; Epitopes; Guinea Pigs; Isoantigens; Neutrophils; Oxygen Consumption; Phorbols; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred SHR; Rats, Inbred WKY; Tetradecanoylphorbol Acetate | 1986 |
Characteristics of the effect of phorbol ester on rat mast cells: interaction with anti-IgE.
Topics: Animals; Antibodies, Anti-Idiotypic; Calcimycin; Calcium; Histamine Release; Immunoglobulin E; In Vitro Techniques; Male; Mast Cells; Phorbols; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Cytoplasmic pH regulation in phorbol ester-activated human neutrophils.
Topics: Cytoplasm; Humans; Hydrogen-Ion Concentration; Ion Channels; Lymphocyte Activation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Pentose Phosphate Pathway; Phorbol Esters; Phorbols; Protein Kinase C; Sodium; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Biphasic effect of phorbol myristate acetate on histamine secretion induced by compound 48/80 in rat peritoneal mast cells.
Topics: Animals; Calcium; Histamine Release; Mast Cells; p-Methoxy-N-methylphenethylamine; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Aluminum; Aluminum Compounds; Angiotensin II; Calcium; Colforsin; Cyclic AMP; Drug Synergism; Fluorides; Glucagon; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Pertussis Toxin; Phorbols; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thionucleotides; Vasopressins; Virulence Factors, Bordetella | 1986 |
Regulation of protein phosphorylation in pancreatic acini. Distinct effects of Ca2+ ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate.
Topics: Amylases; Animals; Calcimycin; Carbachol; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Pancreas; Phorbols; Phosphorylation; Proteins; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Onc-gene expression in hyperplasia induced by tape stripping or by topical application of TPA.
Topics: Administration, Topical; Animals; Ear; Epidermis; Guinea Pigs; Hyperplasia; Nucleic Acid Hybridization; Oncogenes; Phorbols; RNA; Tetradecanoylphorbol Acetate | 1986 |
Studies on the lethal hit stage of natural killer cell-mediated cytotoxicity. I. Both phorbol ester and ionophore are required for release of natural killer cytotoxic factors (NKCF), suggesting a role for protein kinase C activity.
Topics: Calcium; Cell Fractionation; Cytotoxicity, Immunologic; Diglycerides; Humans; Immunity, Innate; Interferons; Ionophores; Killer Cells, Natural; Killer Factors, Yeast; Phorbols; Phosphatidylinositols; Protein Kinase C; Proteins; Secretory Rate; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
The coregulation of secretion and cytoplasmic ribonucleic acid of chromogranin-A and calcitonin by phorbol ester in cells that produce both substances.
Topics: Calcitonin; Cell Line; Chromogranin A; Chromogranins; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Nerve Tissue Proteins; Nucleic Acid Hybridization; Phorbol Esters; Phorbols; RNA; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1988 |
Modulation of adenylate cyclase in human keratinocytes by protein kinase C.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Line; Epidermis; Humans; Isoproterenol; Keratins; Pertussis Toxin; Phorbol Esters; Phorbols; Propranolol; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colony-Forming Units Assay; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Erythropoietin; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cells; Indomethacin; Interleukin-3; Isoquinolines; Mice; Phorbols; Piperazines; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Characterization of the effects of phorbol esters on rat mast cell secretion.
Topics: Animals; Calcimycin; Calcium; Concanavalin A; Histamine Release; Kinetics; Mast Cells; Phorbol Esters; Phorbols; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester (TPA) potentiates noradrenaline and acetylcholine-evoked amylase secretion in the rat pancreas.
Topics: Acetylcholine; Amylases; Animals; Bucladesine; Calcimycin; Drug Synergism; Norepinephrine; Pancreas; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1985 |
Development of phorbol ester responsiveness in neonatal mouse epidermis: correlation between hyperplastic response and sensitivity to first-stage tumor promotion.
Topics: Animals; DNA; Female; Hyperplasia; Keratins; Mice; Mice, Inbred Strains; Mitosis; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Modulatory effects of 5-azacytidine, phorbol ester, and retinoic acid on the malignant phenotype of human lung cancer cells.
Topics: Animals; Azacitidine; Carcinoma, Small Cell; Cell Line; Clone Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Mitosis; Neoplasm Transplantation; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Phorbol ester-induced changes of cytoplasmic pH in neutrophils: role of exocytosis in Na+-H+ exchange.
Topics: Amiloride; Animals; Cytochalasin B; Cytoplasmic Granules; Exocytosis; Hydrogen-Ion Concentration; Ion Channels; Neutrophils; Phorbols; Sodium; Swine; Tetradecanoylphorbol Acetate | 1985 |
Comparison of the expression of IL 2 receptors by human T and B cells: induction by the polyclonal mitogens, phorbol myristate acetate, and anti-mu antibody.
Topics: alpha-Macroglobulins; Antibodies, Monoclonal; Antigens, Surface; B-Lymphocytes; Binding, Competitive; Dose-Response Relationship, Immunologic; Drug Synergism; Humans; Immunoglobulin M; Kinetics; Leukocyte Count; Lymphocyte Activation; Mitogens; Molecular Weight; Phorbols; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin-2; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1985 |
Synergism between lysophosphatidylserine and the phorbol ester tetradecanoylphorbolacetate in rat mast cells.
Topics: Animals; Calcium; Drug Synergism; Edetic Acid; Histamine Release; Lysophospholipids; Male; Mast Cells; Phorbols; Phosphatidylserines; Rats; Tetradecanoylphorbol Acetate | 1985 |
Stimulation and inhibition of secretion by phorbol myristate acetate in different cell types.
Topics: Animals; Blood Platelets; Calcimycin; Cell Line; Drug Interactions; Granulocytes; Histamine Release; Humans; Lysosomes; Mast Cells; N-Formylmethionine Leucyl-Phenylalanine; Phorbols; Rats; Serotonin; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
12-O-tetradecanoyl-phorbol-13-acetate-induced differentiation of human neuroblastoma cells is not accompanied by an increase in the intracellular concentration of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Clone Cells; Colchicine; Cyclic AMP; Mice; Neoplasms, Experimental; Neuroblastoma; Phorbols; Protein Binding; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter inhibition of cellular binding of somatostatin.
Topics: Amylases; Animals; Calcium; Carcinogens; Cell Membrane; Ceruletide; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Pancreas; Phorbol Esters; Phorbols; Somatostatin; Temperature; Tetradecanoylphorbol Acetate | 1985 |
Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter.
Topics: Amiloride; Animals; Bucladesine; Calcimycin; Carrier Proteins; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Hydrogen-Ion Concentration; Jejunum; Male; Microvilli; Phorbol Esters; Phorbols; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Theophylline | 1988 |
Heterologous down-regulation of vascular atrial natriuretic peptide receptors by phorbol esters.
Topics: Animals; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Differences in transferrin receptor function between normal developing and transformed myogenic cells as revealed by differential effects of phorbol ester on receptor distribution and rates of iron uptake.
Topics: Animals; Avian Sarcoma Viruses; Biological Transport; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Conalbumin; DNA Replication; Iron; Kinetics; Muscles; Phorbols; Receptors, Transferrin; Tetradecanoylphorbol Acetate | 1988 |
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Cyclic AMP; Drug Synergism; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Lymphoma; Manganese; Phorbols; Protein Kinase C; Protein Kinases; Somatostatin; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Stimulation of prostaglandin E2 production by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters in macrophages and its inhibition by cycloheximide.
Topics: Acrylamides; Animals; Carcinogens; Cnidarian Venoms; Cycloheximide; Dinoprostone; Lyngbya Toxins; Macrophages; Male; Phorbols; Prostaglandins E; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; Golgi Apparatus; Histocytochemistry; Humans; Lysosomes; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester and calcium act synergistically to enhance neurotransmitter release by brain neurons in culture.
Topics: Animals; Brain Chemistry; Calcium; Cells, Cultured; Dopamine; Drug Synergism; Fetus; Neurons; Neurotransmitter Agents; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Synergism and antagonism in the effects of 1 alpha,25-dihydroxyvitamin D3, retinoic acid, dexamethasone, and a tumor-promoting phorbol ester on the functional capability of P388D1 cells: phagocytosis and transglutaminase activity.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acyltransferases; Animals; Calcitriol; Cell Differentiation; Cell Line; Dexamethasone; Drug Synergism; Lymphoma; Mice; Phagocytosis; Phenotype; Phorbols; Prostaglandins; Tetradecanoylphorbol Acetate; Transglutaminases; Tretinoin | 1985 |
Inhibition of phorbol ester-caused synthesis of mouse epidermal ornithine decarboxylase by retinoic acid.
Topics: Acyltransferases; Animals; Antibodies, Monoclonal; Enzyme Induction; Female; Male; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Transglutaminases; Tretinoin | 1985 |
Phorbol esters affect pituitary growth hormone (GH) and prolactin release: the interaction with GH releasing factor, somatostatin and bromocriptine.
Topics: Animals; Bromocriptine; Cells, Cultured; Dopamine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Lyngbya Toxins; Male; Phorbols; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Protein Kinases; Rats; Secretory Rate; Somatostatin; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cells, Cultured; Concanavalin A; Enzyme Activation; Glioma; Isoproterenol; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Receptors, Adrenergic, beta; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1985 |
Transglutaminase activity increases in HL60 cells induced to differentiate with retinoic acid and TPA but not with DMSO.
Topics: Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Humans; Leukemia, Myeloid, Acute; Macrophages; Monocytes; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Transglutaminases; Tretinoin | 1985 |
Phorbol ester inhibition of hormonal induction of tyrosine aminotransferase.
Topics: Animals; Bucladesine; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Insulin; Liver Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate; Tyrosine Transaminase | 1985 |
TPA (12-O-tetradecanoyl-phorbol-13-acetate) as a carcinogen for mouse skin. A positive dose-response relationship.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulates somatostatin release from isolated perfused rat stomach.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Mucosa; Glucagon; In Vitro Techniques; Kinetics; Male; Perfusion; Phorbols; Rats; Rats, Inbred Strains; Somatostatin; Tetradecanoylphorbol Acetate | 1985 |
A combination of palytoxin with 1-oleoyl-2-acetyl-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combinations of 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters with OAG do not.
Topics: 6-Ketoprostaglandin F1 alpha; Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Line; Cnidarian Venoms; Diglycerides; Dinoprost; Drug Synergism; Glycerides; Insulin; Interleukin-1; Kinetics; Liver; Phorbols; Prostaglandins F; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester or diacylglycerol modulates somatostatin binding to its receptors on rat pancreatic acinar cell membranes.
Topics: Animals; Autoradiography; Binding, Competitive; Diglycerides; Dose-Response Relationship, Drug; Glycerides; Male; Pancreas; Phorbols; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin; Tetradecanoylphorbol Acetate | 1986 |
The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture.
Topics: Animals; Carnitine O-Acetyltransferase; Catalase; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Glutamate Dehydrogenase; Mice; Microbodies; NADPH-Ferrihemoprotein Reductase; Palmitoyl-CoA Hydrolase; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Effects of phorbol ester on GH, TSH and PRL release by superfused rat adenohypophysis.
Topics: Animals; Dimethyl Sulfoxide; Female; Growth Hormone; In Vitro Techniques; Kinetics; Perfusion; Phorbols; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Somatostatin; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone | 1985 |
Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction.
Topics: Animals; Calcium; In Vitro Techniques; Kinetics; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Phorbols; Rana pipiens; Rana temporaria; Tetradecanoylphorbol Acetate | 1986 |
The influence of different fixatives and a tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), on the induction of so-called dark cells in mouse epidermis. A light microscopical study.
Topics: Acetone; Animals; Carcinogens; Cocarcinogenesis; Fixatives; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion].
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cnidarian Venoms; Enzyme Activation; Humans; Lyngbya Toxins; Mice; Neoplasms, Experimental; Phorbols; Plant Extracts; Protein Kinase C; Receptors, Cell Surface; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thapsigargin | 1986 |
Islet priming by phorbol ester.
Topics: Animals; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Phorbols; Rats; Rats, Inbred Strains; Somatostatin; Tetradecanoylphorbol Acetate | 1986 |
Combinations of palytoxin or 12-O-tetradecanoylphorbol-13-acetate and recombinant human insulin growth factor-I or insulin synergistically stimulate prostaglandin production in cultured rat liver cells and squirrel monkey aorta smooth muscle cells.
Topics: Acrylamides; Animals; Cnidarian Venoms; Drug Synergism; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Liver; Muscle, Smooth, Vascular; Phorbols; Prostaglandins; Rats; Recombinant Proteins; Saimiri; Somatomedins; Tetradecanoylphorbol Acetate | 1986 |
Induction of desensitization by phorbol ester to beta-adrenergic agonist stimulation in adenylate cyclase system of rat reticulocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Diglycerides; Guanylyl Imidodiphosphate; Isoproterenol; Isoquinolines; Male; Phorbols; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Reticulocytes; Tetradecanoylphorbol Acetate | 1986 |
Phosphatidylserine and phorbol myristate acetate stimulation of human lymphocyte guanylate cyclase.
Topics: Adult; Cytosol; Enzyme Activation; Guanylate Cyclase; Humans; Kinetics; Lymphocytes; Phorbols; Phosphatidylserines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C.
Topics: Animals; Arachidonic Acids; Bradykinin; Calcimycin; Cell Line; Dogs; Enzyme Activation; Hydrolysis; Kidney; Kinetics; Neomycin; Phorbols; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Protein kinase C mediates the hormonally regulated plasma membrane fusion of avian embryonic skeletal muscle.
Topics: Alprostadil; Animals; Cell Fusion; Cells, Cultured; Chick Embryo; Diglycerides; DNA; Enzyme Activation; Indomethacin; Muscles; Myosins; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Tumor-promoting phorbol esters inhibit monocyte adherence to endothelial cells.
Topics: Animals; Aorta; Carcinogens; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Male; Monocytes; Phorbol 12,13-Dibutyrate; Phorbols; Tetradecanoylphorbol Acetate | 1989 |
Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.
Topics: 3-O-Methylglucose; Animals; Carcinogens; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Fibroblasts; Fructosediphosphates; Glycerol; Glycolysis; Hexosediphosphates; Insulin; Lactates; Methylglucosides; Phorbols; Phosphofructokinase-1; Tetradecanoylphorbol Acetate | 1985 |
Modulation of complement receptors of a human monocyte cell line, U-937, during incubation with phorbol myristate acetate: expression of an iC3b-specific receptor (CR3).
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Cell Line; Culture Media; Edetic Acid; Humans; Kinetics; Macrophages; Monocytes; Phorbols; Receptors, Complement; Receptors, Complement 3b; Rosette Formation; Tetradecanoylphorbol Acetate | 1985 |
12-O-Tetradecanoylphorbol-13-acetate enhances glycolysis in rat thymocytes.
Topics: Animals; Glycolysis; Hexokinase; In Vitro Techniques; Kinetics; Male; Phorbols; Phosphofructokinase-1; Pyruvate Kinase; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thymus Gland | 1985 |
Mechanism of TPA stimulation of arachidonic acid metabolism in rat liver C-9 cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Kinetics; Liver; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Complement Activation; Humans; Neutrophils; Phagocytosis; Phorbols; Phosphorylation; Receptors, Complement; Receptors, Complement 3b; Receptors, Fc; Receptors, IgG; Rosette Formation; Sheep; Tetradecanoylphorbol Acetate | 1986 |
Antipromotional activity of dietary N-(4-hydroxyphenyl)retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diet; Drug Antagonism; Female; Fenretinide; Mice; Mice, Inbred Strains; Neoplasms, Multiple Primary; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Diglycerides; Enzyme Activation; Isradipine; Mice; Neural Crest; Oxadiazoles; Phorbol Esters; Phorbols; Potassium; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
12-O-tetradecanoylphorbol-13-acetate disrupts actin filaments and focal contacts and enhances binding of fibronectin-coated latex beads to 3T3-L1 cells.
Topics: Actin Cytoskeleton; Actins; Animals; Cell Adhesion; Cell Division; Cell Line; Cell Membrane; Cytoskeleton; Fibroblasts; Fibronectins; Humans; Microscopy, Electron, Scanning; Microspheres; Phagocytosis; Phorbols; Receptors, Fibronectin; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1988 |
Biochemical models of gamma-interferon action: altered expression of transferrin receptors on murine peritoneal macrophages after treatment in vitro with PMA or A23187.
Topics: Animals; Calcimycin; Cells, Cultured; Interferon-gamma; Kinetics; Macrophages; Mice; Mice, Inbred C57BL; Phorbol Esters; Phorbols; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1985 |
Modulation of the sodium periodate (NaIO4) response in systemic lupus erythematosus (SLE): effect of interleukin-1 (IL-1), interleukin-2 (IL-2), phorbol myristate acetate (PMA), and indomethacin.
Topics: Female; Humans; Indomethacin; Interleukin-1; Interleukin-2; Lupus Erythematosus, Systemic; Male; Mitogens; Neutrophils; Periodic Acid; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Stimulus-dependent inhibition of superoxide generation by prostaglandins.
Topics: Alprostadil; Cyclic AMP; Depression, Chemical; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Prostaglandins; Prostaglandins E; Protein Binding; Superoxides; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1985 |
12-O-tetradecanoyl phorbol-13-acetate stimulates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor.
Topics: Animals; Bucladesine; Growth Hormone; Growth Hormone-Releasing Hormone; Peptide Fragments; Phorbols; Phospholipase D; Phospholipases A; Pituitary Gland, Anterior; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl-CoA synthetase on incubation of adipocytes with the tumour promoter 12-O-tetradecanoylphorbol 13-acetate.
Topics: Adipose Tissue; Animals; Coenzyme A Ligases; Enzyme Activation; Lipolysis; Norepinephrine; Phorbols; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1985 |
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets.
Topics: Blood Platelets; Calcium; Carcinogens; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylinositols; Platelet Activating Factor; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Thrombin; Vasopressins | 1985 |
Antiviral activity of phorbol myristate acetate and possible relationships with interferon action.
Topics: Antiviral Agents; Calcium; Cell Line; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Diglycerides; Female; Humans; Interferon Type I; Membrane Lipids; Phorbols; Phospholipids; Pregnancy; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Vesicular stomatitis Indiana virus | 1985 |
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Glycerides; Humans; Mice; Mitosis; Phorbol Esters; Phorbols; Phospholipids; Phosphoproteins; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Hydroxides; Hydroxyl Radical; Lipoxygenase Inhibitors; Mannitol; Mice; Phorbols; Skin Neoplasms; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters stimulate growth and inhibit differentiation in cultured thyroid cells.
Topics: Animals; Biological Transport; Cell Differentiation; Cell Division; Cells, Cultured; Cyclic AMP; Diglycerides; DNA; Epidermal Growth Factor; Iodine; Phorbols; Sheep; Tetradecanoylphorbol Acetate; Thyroid Gland; Time Factors | 1985 |
Alkaline deoxyribonuclease induced with diterpene ester TPA and n-butyrate in Epstein-Barr virus genome-carrying Raji cells.
Topics: Animals; Butyrates; Cell Line; Cell Transformation, Viral; Chromatography, DEAE-Cellulose; Deoxyribonucleases; Enzyme Induction; Herpesvirus 4, Human; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.
Topics: Acetylglucosaminidase; Animals; Calcimycin; Calcium; Cytoplasmic Granules; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Rabbits; Sodium; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.
Topics: Animals; Calcimycin; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Glucagon; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Phentolamine; Phorbols; Phosphorylase a; Propranolol; Protein Kinase C; Protein Kinases; Rats; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1985 |
Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.
Topics: Animals; Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; Female; Fibroblasts; Humans; Interleukin-1; Metalloendopeptidases; Methionine; Microbial Collagenase; Phorbols; Pregnancy; Protease Inhibitors; Sheep; Tetradecanoylphorbol Acetate | 1985 |
Human B cell responsiveness to B cell growth factor after activation by phorbol ester and monoclonal anti-mu antibody.
Topics: Absorption; Animals; Antibodies, Monoclonal; B-Lymphocytes; Drug Synergism; Goats; Growth Substances; Humans; Immunoglobulin Heavy Chains; Immunoglobulin mu-Chains; Interferon-gamma; Interleukin-4; Interphase; Lymphocyte Activation; Lymphokines; Mice; Mitogens; Phorbols; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin-2; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Tumor promoter phorbol-12-myristate-13-acetate induces poly ADP-ribosylation in human monocytes.
Topics: Antioxidants; Benzamides; DNA; Humans; In Vitro Techniques; Monocytes; NAD; Nucleoside Diphosphate Sugars; Nucleotidyltransferases; Phorbols; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells.
Topics: Animals; Calcium; Carbachol; Cell Line; Hydrolysis; Kinetics; Neurosecretory Systems; Phorbols; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1985 |
Dehydroepiandrosterone and 16 alpha-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes.
Topics: Androsterone; Dehydroepiandrosterone; Free Radicals; Glucosephosphate Dehydrogenase; Humans; In Vitro Techniques; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter.
Topics: Animals; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Peptides; Phorbols; Rats; Receptors, Cell Surface; Sarcoma Viruses, Feline; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.
Topics: Amino Acid Sequence; Carcinoma; Cells, Cultured; ErbB Receptors; Fibroblasts; Humans; Phorbols; Phosphopeptides; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Trypsin | 1985 |
In vitro induction of cytologic and functional differentiation of the immature human monocytelike cell line U-937 with phorbol myristate acetate.
Topics: Cell Differentiation; Cell Line; Chemotaxis, Leukocyte; Humans; Kinetics; Microscopy, Electron; Microscopy, Fluorescence; Monocytes; Phagocytosis; Phorbols; Receptors, Fc; Rosette Formation; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Ca2+- or phorbol ester- dependent effect of ATP on a subpopulation of cAMP cell-surface receptors in membranes from D. discoideum. A role for protein kinase C.
Topics: Adenosine Triphosphate; Calcium; Cyclic AMP; Dictyostelium; Guanine Nucleotides; Kinetics; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cyclic AMP; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes.
Topics: B-Lymphocytes; Cell Line; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Interleukin-2; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate | 1985 |
Insulin release independent of a rise in cytosolic free Ca2+ by forskolin and phorbol ester.
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Digitonin; Diterpenes; Insulin; Islets of Langerhans; Male; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Humans; Hydrolysis; Phorbol Esters; Phorbols; Phosphatidylinositols; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1985 |
Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.
Topics: Animals; Carcinogens; Cell Line; Diglycerides; ErbB Receptors; Glycerides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Two receptor classes for epidermal growth factor on pheochromocytoma cells, distinguishable by temperature, lectins, and tumor promoters.
Topics: Animals; Cell Membrane; Cells, Cultured; Concanavalin A; ErbB Receptors; Pheochromocytoma; Phorbols; Rats; Receptors, Cell Surface; Temperature; Tetradecanoylphorbol Acetate | 1985 |
Effects of tumor promoters on sodium ion transport across frog skin.
Topics: Amiloride; Animals; Biological Transport, Active; Carcinogens; Cyclic AMP; Indomethacin; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rana pipiens; Skin; Sodium; Tetradecanoylphorbol Acetate | 1985 |
Production of superoxide anion by bovine pulmonary macrophages challenged with soluble and particulate stimuli.
Topics: Animals; Cattle; Colorimetry; Immune Sera; Macrophages; Male; Pasteurella; Phorbols; Pulmonary Alveoli; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1985 |
Phorbol 12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Neutrophils; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rabbits; Sodium Chloride; Tetradecanoylphorbol Acetate | 1985 |
Inhibition by verapamil of neutrophil responses to formylmethionylleucylphenylalanine and phorbol myristate acetate. Mechanisms involving Ca2+ changes, cyclic AMP and protein kinase C.
Topics: Calcium; Cell Membrane; Cyclic AMP; Cytoplasmic Granules; Cytosol; Enzyme Activation; Humans; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phorbols; Phosphatidylserines; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Verapamil | 1985 |
Stimulation of spontaneous transmitter release by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C.
Topics: Animals; In Vitro Techniques; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Phorbols; Protein Kinase C; Protein Kinases; Rana pipiens; Synaptic Transmission; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester regulation of rat granulosa cell prostaglandin and progesterone accumulation.
Topics: Animals; Cyclic AMP; Female; Granulosa Cells; In Vitro Techniques; Luteinizing Hormone; Phorbols; Pituitary Hormone-Releasing Hormones; Progesterone; Prostaglandins; Prostaglandins E; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1985 |
Effects of epidermal growth factor, phorbol myristate acetate, and arachidonic acid on choriogonadotropin secretion by cultured human choriocarcinoma cells.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Catechols; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Indomethacin; Masoprocol; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pregnancy; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 1985 |
An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations.
Topics: 2-Chloroadenosine; Adenosine; Animals; Cell-Free System; Cerebral Cortex; Cyclic AMP; Drug Synergism; Enzyme Activation; Guinea Pigs; Inositol Phosphates; Male; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.
Topics: Cell Differentiation; Cell Division; Cell Line; Diglycerides; Enzyme Activation; Humans; Leukemia, Myeloid, Acute; Neoplasm Proteins; Phorbols; Phosphatidylcholines; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate | 1985 |
Studies of cytochrome b-245 translocation in the PMA stimulation of the human neutrophil NADPH-oxidase.
Topics: Cell Compartmentation; Cytochrome b Group; Cytoplasmic Granules; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.
Topics: Aminoquinolines; Blood Platelets; Calcimycin; Calcium; Humans; Lipid Metabolism; Phorbol Esters; Phorbols; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Thrombin | 1985 |
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.
Topics: Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Oncogenes; Peptide Fragments; Phorbols; Phosphorylation; Platelet-Derived Growth Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine | 1985 |
Polymyxin B causes coordinate inhibition of phorbol ester-induced C-kinase activity and proliferation of B lymphocytes.
Topics: B-Lymphocytes; Calcium; Humans; In Vitro Techniques; Lymphocyte Activation; Phorbols; Phosphatidylserines; Phosphorylation; Polymyxin B; Polymyxins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced nitroblue tetrazolium reduction in mouse peritoneal macrophages by various tumor promotion inhibitors.
Topics: Animals; Antioxidants; Cyclooxygenase Inhibitors; Female; In Vitro Techniques; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Inbred ICR; NADH Dehydrogenase; Nitroblue Tetrazolium; Oxidation-Reduction; Phorbols; Phospholipases A; Phospholipases A2; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tetrazolium Salts | 1985 |
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Free Radicals; Lipoxygenase Inhibitors; Luminescent Measurements; Mice; Neutrophils; Phorbols; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting, phorbol ester-induced phosphorylation of cell-surface transferrin receptors in human erythroleukemia cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Erythroblastic, Acute; Mice; Phorbols; Phosphorylation; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1985 |
Phorbol ester inhibits myoblast fusion and activates beta-adrenergic receptor coupled adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Fusion; Cells, Cultured; Chick Embryo; Creatine Kinase; Isoenzymes; Kinetics; Muscles; Phorbols; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1985 |
The Na+/H+ antiport is activated by serum and phorbol esters in proliferating myoblasts but not in differentiated myotubes. Properties of the activation process.
Topics: Amiloride; Animals; Blood; Carrier Proteins; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Epidermal Growth Factor; Hydrogen-Ion Concentration; Kinetics; Muscle Development; Phorbol Esters; Phorbols; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.
Topics: Adenylyl Cyclases; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Chorionic Gonadotropin; Diglycerides; Dose-Response Relationship, Drug; Kinetics; Leydig Cell Tumor; Male; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Receptors, LH; Testicular Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
[Genetic transformation of somatic cells. IV. The rate of loss of transformant phenotype depends on the structure of the transforming DNA and changes when the cells are treated with the tumor promotor 12-o-tetradecanoyl-phorbol-13-acetate].
Topics: Animals; Cell Transformation, Viral; Clone Cells; Cricetinae; Cricetulus; DNA; Genes, Viral; Phenotype; Phorbols; Simplexvirus; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transformation, Genetic | 1985 |
A tumor promoter enhances the phosphorylation of polyphosphoinositides while decreasing phosphatidylinositol labelling in lymphocytes.
Topics: Animals; Concanavalin A; Diacylglycerol Kinase; Female; Glycerol; In Vitro Techniques; Lymphocytes; Mice; Phorbols; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Spleen; Tetradecanoylphorbol Acetate | 1985 |
Modulation of the activity of the platelet-derived growth factor receptor by phorbol myristate acetate.
Topics: Animals; Blood; Carrier Proteins; Cattle; Cell Line; Female; Hydrogen-Ion Concentration; Intracellular Fluid; Phorbols; Platelet-Derived Growth Factor; Pregnancy; Rats; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1985 |
Antiproliferative properties of phorbol ester tumour promoters.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Epidermal Growth Factor; Humans; Hydroxides; Hydroxyl Radical; Neutrophils; Oxygen; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
The phorbol ester TPA prevents the expression of both glucagon desensitisation and the glucagon-mediated block of insulin stimulation of the peripheral plasma membrane cyclic AMP phosphodiesterase in rat hepatocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Membrane; Drug Interactions; Glucagon; In Vitro Techniques; Insulin; Liver; Male; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Differential phosphorylation of multiple sites in protein 4.1 and protein 4.9 by phorbol ester-activated and cyclic AMP-dependent protein kinases.
Topics: Blood Proteins; Bucladesine; Cytoskeletal Proteins; Erythrocyte Membrane; Humans; Kinetics; Membrane Proteins; Microfilament Proteins; Neuropeptides; Peptide Fragments; Phorbols; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Mechanism of phorbol diester-induced regulation of surface transferrin receptor involves the action of activated protein kinase C and an intact cytoskeleton.
Topics: Cell Line; Cytoskeleton; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1985 |
Phorbol ester-induced loss of colchicine ultrasensitivity in chronic lymphocytic leukaemia lymphocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aged; Cell Survival; Colchicine; Drug Resistance; Female; Humans; In Vitro Techniques; Leukemia, Lymphoid; Lymphocytes; Male; Middle Aged; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Coregulation of collagenase and collagenase inhibitor production by phorbol myristate acetate in human skin fibroblasts.
Topics: Cell Compartmentation; Cells, Cultured; Culture Media; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Microbial Collagenase; Phorbols; Protein Biosynthesis; Skin; Tetradecanoylphorbol Acetate; Time Factors; Tissue Inhibitor of Metalloproteinases | 1985 |
Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester.
Topics: Aminoquinolines; Animals; Bacterial Toxins; Calcium; Cytoplasmic Granules; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Platelet Activating Factor; Rabbits; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1985 |
Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes.
Topics: Cell Division; Diglycerides; Enzyme Activation; Humans; Interleukin-2; Lymphocytes; Lyngbya Toxins; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin-2; Receptors, Transferrin; Rosette Formation; Tetradecanoylphorbol Acetate | 1985 |
Caffeine and other phosphodiesterase inhibitors are potent inhibitors of the promotional effect of TPA on morphological transformation of hamster embryo cells.
Topics: Adenylyl Cyclases; Animals; Bucladesine; Caffeine; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cyclic AMP; Mesocricetus; Phorbols; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of metabolic cooperation by phorbol esters in a cell culture system based on adenosine kinase deficient mutants of V79 cells.
Topics: Adenosine; Adenosine Kinase; Animals; Cell Communication; Cell Count; Cell Line; Cricetinae; Cricetulus; Diphtheria Toxin; Dose-Response Relationship, Drug; Drug Resistance; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Phorbol Esters; Phorbols; Phosphorylation; Phosphotransferases; Tetradecanoylphorbol Acetate; Tubercidin | 1985 |
Phorbol ester stimulates catecholamine synthesis in isolated bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Bucladesine; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; In Vitro Techniques; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Effect of phorbol ester and phospholipase C on LH-stimulated steroidogenesis in purified rat Leydig cells.
Topics: Animals; Chorionic Gonadotropin; Cyclic AMP; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Phorbol Esters; Phorbols; Phosphatidylinositols; Phospholipases; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Testosterone; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1985 |
In vitro maturation of B cells in chronic lymphocytic leukemia. I. Synergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells.
Topics: Antibodies, Monoclonal; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Drug Synergism; Humans; Interleukin-2; Kinetics; Leukemia, Lymphoid; Lymphocyte Activation; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1985 |
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
Topics: Animals; Cell Line; Cricetinae; Enzyme Activation; Male; Molecular Weight; Norepinephrine; Phorbols; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vas Deferens | 1985 |
Combined effect of phorbol ester and, A23187 or dibutyryl cyclic AMP on pepsinogen secretion from isolated gastric glands.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Gastric Mucosa; Guinea Pigs; Pepsinogens; Phorbols; Protein Kinase C; Protein Kinases; Sincalide; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting phorbol esters and vanadate alter the sensitivity of HeLa S3 cells to poliovirus type 1.
Topics: Cell Membrane; HeLa Cells; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Poliovirus; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1985 |
Inhibition of vasopressin-stimulated water flow in toad bladder by phorbol myristate acetate, dioctanoylglycerol, and RHC-80267. Evidence for modulation of action of vasopressin by protein kinase C.
Topics: Animals; Anura; Biological Transport, Active; Body Water; Cyclic AMP; Cyclohexanes; Cyclohexanones; Diglycerides; Dinoprostone; Epithelium; Female; Glycerides; Lipoprotein Lipase; Mucous Membrane; Phorbols; Prostaglandins E; Protein Kinase C; Serous Membrane; Tetradecanoylphorbol Acetate; Urinary Bladder; Vasopressins | 1985 |
Activation of yeast plasma membrane ATPase by phorbol ester.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Cell Membrane; Cyclic AMP; Enzyme Activation; Glucose; Hydrogen-Ion Concentration; Kinetics; Membrane Proteins; Phorbols; Phosphorylation; Saccharomyces cerevisiae; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.
Topics: Aminoquinolines; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Cytosol; Diglycerides; Enzyme Activation; Fluorescent Dyes; Glycerides; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Muscle, Smooth, Vascular; Phorbols; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.
Topics: Animals; Cell Line; Colforsin; Cyclic AMP; Drug Synergism; Lymphoma; Mice; Phorbols; Phosphorylation; Proteins; Tetradecanoylphorbol Acetate | 1985 |
Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate. Brief report.
Topics: Butyrates; Butyric Acid; Cell Fusion; Cells, Cultured; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Lymphocytes; Microscopy, Electron; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Detection of a countertranscript in promyelocytic leukemia cells HL60 during early differentiation by TPA.
Topics: Base Sequence; Cell Differentiation; Cell Line; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Humans; Leukemia, Myeloid, Acute; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1985 |
Phorbol ester stimulates calcitonin secretion synergistically with A23187, and additively with dibutyryl cyclic AMP in a rat C-cell line.
Topics: Animals; Bucladesine; Calcimycin; Calcitonin; Cell Line; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Drug Synergism; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1985 |
Activators of protein kinase C stimulate meiotic maturation of rat oocytes.
Topics: Animals; Cyclic AMP; Diglycerides; Enzyme Activation; Female; Glycerides; Gonadotropins, Equine; Meiosis; Oocytes; Oogenesis; Phorbols; Protein Kinase C; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1985 |
Tetradecanoyl phorbol-13-acetate counteracts the responsiveness of cultured thyroid cells to thyrotropin.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Phorbols; Phospholipids; Proteins; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1985 |
Polymyxin B inhibits phorbol 12-myristate 13-acetate, but not chemotactic factor, induced effects in rabbit neutrophils.
Topics: Animals; Chemotactic Factors; Cytoplasmic Granules; In Vitro Techniques; Muramidase; Neutrophils; Phorbols; Polymyxin B; Polymyxins; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1985 |
Differential effects of the tumor promoter phorbol-12-myristate-13-acetate on the morphological and biochemical differentiation of N-18 mouse neuroblastoma cells.
Topics: Acetylcholinesterase; Animals; Axons; Bucladesine; Carrier Proteins; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP Receptor Protein; Fetal Blood; Growth Inhibitors; Mice; Neuroblastoma; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Differences in the mode of action of 1-oleoyl-2-acetyl-glycerol and phorbol ester in platelet activation.
Topics: Adenylyl Cyclases; Apyrase; Blood Platelets; Blood Proteins; Colforsin; Cyclic AMP; Diglycerides; Glycerides; Humans; Kinetics; Papaverine; Phorbols; Phosphorylation; Platelet Aggregation; Tetradecanoylphorbol Acetate | 1985 |
Activation of Na+/H+ exchange in cultured fibroblasts: synergism and antagonism between phorbol ester, Ca2+ ionophore, and growth factors.
Topics: Animals; Biological Transport; Calcimycin; Carrier Proteins; Cells, Cultured; Drug Synergism; Growth Substances; Humans; Mice; Phorbols; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine.
Topics: Angiotensin II; Animals; Calcium; Epinephrine; Female; Kinetics; Liver; Liver Glycogen; Phorbols; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Urea; Vasopressins | 1986 |
Epidermal growth factor regulates the expression of its own receptor.
Topics: Cells, Cultured; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Kinetics; Phorbols; Receptors, Cell Surface; RNA, Messenger; Tetradecanoylphorbol Acetate | 1985 |
Differential effects of phorbol ester on the beta-adrenergic response of normal and ras-transformed NIH3T3 cells.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; DNA, Neoplasm; Fibroblasts; Humans; Isoproterenol; Mice; Mice, Nude; Oncogenes; Phenotype; Phorbols; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms | 1985 |
Concanavalin A and phorbol ester cause opposite subcellular redistribution of protein kinase C.
Topics: Coenzymes; Concanavalin A; Cytosol; Enzyme Activation; Humans; Monocytes; Phorbols; Protein Kinase C; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Analysis of T cell activation with a non-mitogenic anti CD3 antibody and the phorbol ester TPA.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Concanavalin A; Humans; Immunoglobulin M; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mitosis; Phorbols; Phytohemagglutinins; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin-2; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester stimulates progesterone production by isolated bovine luteal cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cattle; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Corpus Luteum; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Female; Kinetics; Luteal Cells; Phorbols; Progesterone; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cells.
Topics: 2-Chloroadenosine; Adenosine; Adrenal Gland Neoplasms; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Pheochromocytoma; Phorbols; Phosphatidylinositols; Protein Kinase C; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diglycerides; Glycerides; Inositol; Male; Ouabain; Oxygen Consumption; Peripheral Nerves; Phorbols; Protein Kinase C; Rabbits; Rats; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate | 1986 |
Tumor promoter enhances mitogenesis by PDGF with little effect on PDGF binding.
Topics: Animals; Cell Division; Cell Line; DNA Replication; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Mice; Phorbols; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1986 |
12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced gene sequences in human primary diploid fibroblasts and their expression in SV40-transformed fibroblasts.
Topics: Bloom Syndrome; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; DNA; Fibroblasts; Gene Expression Regulation; Humans; Phorbols; RNA, Messenger; Simian virus 40; Tetradecanoylphorbol Acetate; Xeroderma Pigmentosum | 1985 |
Reversal by protein kinase C inhibitor of suppressive actions of phorbol-12-myristate-13-acetate on polyphosphoinositide metabolism and cytosolic Ca2+ mobilization in thrombin-stimulated human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Phorbols; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Effect of phorbol esters on the activity of purified transforming growth factors.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Kidney; Peptides; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1986 |
[Potentiation by phorbol ester, a protein kinase activator, of the effect of prostaglandin E1 on human platelets].
Topics: Alprostadil; Blood Platelets; Cyclic AMP; Drug Synergism; Enzyme Activation; Humans; In Vitro Techniques; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1986 |
The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.
Topics: Calpain; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Activation; Humans; Neutrophils; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Estrogens; Humans; Lyngbya Toxins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phorbols; Progesterone; Protein Kinase C; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of the apparent affinity of the epidermal growth factor receptor caused by phorbol diesters correlates with phosphorylation of threonine-654 but not other sites on the receptor.
Topics: Amiloride; Amino Acids; Binding Sites; Carcinoma, Squamous Cell; Cell Line; ErbB Receptors; Humans; Phorbols; Phosphopeptides; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine | 1986 |
Potentiation of prostaglandin E1-stimulated cAMP formation by 12-O-tetradecanoylphorbol-13-acetate in BALB/c mouse 3T3 cells.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Kinetics; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Effect of the calcium ionophore A23187 on superoxide generation in phorbol ester stimulated human neutrophils.
Topics: Calcimycin; Calcium; Humans; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Lysosomes; Neutrophils; Oxygen Consumption; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L.
Topics: Biological Assay; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Lyngbya Toxins; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Phorbols; Plants, Medicinal; Sapogenins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid; Virus Activation; Virus Cultivation | 1986 |
Phorbol ester enhances both interleukin 2 receptor expression and immunoglobulin secretion in human Epstein-Barr virus-immortalized B cells.
Topics: Antigens, Surface; B-Lymphocytes; Cell Differentiation; Cell Transformation, Viral; Cells, Cultured; Herpesvirus 4, Human; Humans; Immunoglobulin M; Immunoglobulins; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1986 |
Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe.
Topics: Adenosine Diphosphate Ribose; Animals; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nucleoside Diphosphate Sugars; Pertussis Toxin; Phorbols; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ErbB Receptors; Female; Glycyrrhetinic Acid; HeLa Cells; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phorbols; Phospholipids; Phosphorus Radioisotopes; Quercetin; Receptors, Cell Surface; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Na+/H+ exchange in Ehrlich ascites tumor cells. Regulation by extracellular ATP and 12-O-tetradecanoylphorbol 13-acetate.
Topics: Adenosine Triphosphate; Amiloride; Animals; Calcium; Carcinoma, Ehrlich Tumor; Carrier Proteins; Hydrogen-Ion Concentration; Kinetics; Mice; Phorbols; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1986 |
Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils.
Topics: Calcium; Drug Synergism; Enzyme Activation; Humans; Hydrolysis; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phorbols; Phosphatidylinositols; Tetradecanoylphorbol Acetate | 1986 |
Complete dissociation between the activation of phosphoinositide turnover and of NADPH oxidase by formyl-methionyl-leucyl-phenylalanine in human neutrophils depleted of Ca2+ and primed by subthreshold doses of phorbol 12,myristate 13,acetate.
Topics: Calcium; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phorbols; Phosphatidylinositols; Tetradecanoylphorbol Acetate | 1986 |
Comparison of inhibition by a tumor promoter (12-O-tetradecanoylphorbol-13-acetate) of expression of the differentiated phenotype of chondrocytes in rabbit costal chondrocytes in culture with inhibition by retinoic acid.
Topics: Animals; Bucladesine; Cartilage; Cell Differentiation; Cells, Cultured; Cyclic AMP; Drug Interactions; Glycosaminoglycans; Ornithine Decarboxylase; Parathyroid Hormone; Phorbols; Proteoglycans; Rabbits; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Superoxide anion release by human endothelial cells: synergism between a phorbol ester and a calcium ionophore.
Topics: Anions; Calcimycin; Dimethyl Sulfoxide; Drug Synergism; Endothelium; Humans; Osmolar Concentration; Phorbols; Superoxides; Tetradecanoylphorbol Acetate; Umbilical Veins | 1986 |
Regulation of hexose transporters in chicken embryo fibroblasts: stimulation by the phorbol ester TPA leads to increased numbers of functioning transporters.
Topics: 5'-Nucleotidase; Animals; Biomechanical Phenomena; Carrier Proteins; Chick Embryo; Cycloheximide; Fibroblasts; Glucose; Guanosine; Nucleotidases; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Regulation of amino acid uptake by phorbol esters and hypertonic solutions in rat thymocytes.
Topics: Amino Acids; Animals; Carrier Proteins; Drug Synergism; Hypertonic Solutions; Male; Membrane Potentials; Phorbols; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sodium; Sodium-Hydrogen Exchangers; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1986 |
1,2-Diacylglycerols mimic phorbol 12-myristate 13-acetate activation of the sea urchin egg.
Topics: Animals; Carrier Proteins; Cytoplasm; Diglycerides; Fertilization; Glycerides; Hydrogen-Ion Concentration; Osmolar Concentration; Ovum; Phorbols; Sea Urchins; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1986 |
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
Topics: Cathepsin G; Cathepsins; Cell Differentiation; Cell Line; Chemotaxis; Cholecalciferol; Cyclic AMP; DNA; Humans; Leukemia, Myeloid, Acute; Macrophages; Microbial Collagenase; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phorbols; Serine Endopeptidases; Tetradecanoylphorbol Acetate | 1986 |
Expression of the protein product of the mouse mammary tumor virus long terminal repeat gene in phorbol ester-treated mouse T-cell-leukemia cells.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Genes, Viral; Leukemia, Experimental; Mammary Tumor Virus, Mouse; Methylation; Mice; Molecular Weight; Peptides; Phorbols; Protein Processing, Post-Translational; Repetitive Sequences, Nucleic Acid; RNA, Messenger; RNA, Viral; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Viral Proteins | 1986 |
Inhibition of phorbol ester-stimulated chemiluminescence and superoxide production in human neutrophils by fructose 1,6-diphosphate.
Topics: Adenosine Triphosphate; Fructosediphosphates; Hexosediphosphates; Humans; In Vitro Techniques; Luminescent Measurements; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Ca2+ and phorbol ester activation of protein kinase C at intracellular Ca2+ concentrations and the effect of TMB-8.
Topics: Animals; Calcium; Cattle; Cells, Cultured; Diglycerides; Enzyme Activation; Gallic Acid; Humans; Intracellular Fluid; Neutrophils; Osmolar Concentration; Phorbols; Phosphatidylserines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters, vasopressin and angiotensin II block alpha 1-adrenergic action in rat hepatocytes. Possible role of protein kinase C.
Topics: Angiotensin II; Animals; Egtazic Acid; Epinephrine; Female; Gluconeogenesis; In Vitro Techniques; Kinetics; Liver; Liver Glycogen; Phorbols; Propranolol; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Urea; Vasopressins | 1986 |
Homologous and heterologous desensitization of one of the pathways of the alpha 1-adrenergic action. Effects of epinephrine, vasopressin, angiotensin II and phorbol 12-myristate 13-acetate.
Topics: Angiotensin II; Animals; Calcium; Epinephrine; Female; In Vitro Techniques; Kinetics; Liver; Phorbols; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasopressins | 1986 |
Differentiation of a cell line from olfactory epithelium is induced by dibutyryladenosine 3',5'-cyclic monophosphate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Action Potentials; Animals; Axons; Benzodiazepinones; Bucladesine; Cell Differentiation; Cell Division; Cell Line; Convulsants; Epithelial Cells; Epithelium; Mice; Nasal Mucosa; Phorbols; Receptors, GABA-A; Tetradecanoylphorbol Acetate | 1986 |
Abolishment of inhibitory effects of 3'-deazaadenosine on superoxide generation of guinea pig phagocytes by pre-exposure to phorbol myristate acetate.
Topics: Animals; Antigen-Antibody Complex; Dose-Response Relationship, Drug; Guinea Pigs; Lectins; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytes; Phorbols; Ribonucleosides; Superoxides; Tetradecanoylphorbol Acetate; Tubercidin; Wheat Germ Agglutinins | 1986 |
Characterization of phorbol ester- and diacylglycerol-stimulated secretion in permeable GH3 pituitary cells. Interaction with Ca2+.
Topics: Animals; Calcium; Cell Line; Cell Membrane Permeability; Diglycerides; Drug Synergism; Glycerides; Kinetics; Phorbols; Phosphatidylinositol Phosphates; Phosphatidylinositols; Pituitary Neoplasms; Prolactin; Proteoglycans; Rats; Tetradecanoylphorbol Acetate | 1986 |
Protein phosphorylation during activation of Na+/H+ exchange by phorbol esters and by osmotic shrinking. Possible relation to cell pH and volume regulation.
Topics: Animals; Carrier Proteins; Cell Membrane; Hydrogen-Ion Concentration; Hypertonic Solutions; In Vitro Techniques; Male; Membrane Lipids; Membrane Proteins; Phorbols; Phospholipids; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thymus Gland | 1986 |
Cyclic AMP and phorbol esters separately induce growth inhibition, calcitonin secretion, and calcitonin gene transcription in cultured human medullary thyroid carcinoma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Calcitonin; Cell Division; Cell Line; Cell Nucleus; Cyclic AMP; Genes; Humans; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transcription, Genetic | 1986 |
The inhibition of neutrophil responsiveness caused by phorbol esters is blocked by the protein kinase C inhibitor H7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcium; Cytosol; Exocytosis; Hexosaminidases; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phorbols; Phosphoproteins; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Phorbol diester modulates alpha-adrenergic receptor-coupled calcium efflux and alpha-adrenergic receptor number in cultured vascular smooth muscle cells.
Topics: Animals; Calcium; Cells, Cultured; Muscle, Smooth, Vascular; Norepinephrine; Phorbols; Prazosin; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate | 1986 |
Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline.
Topics: Adenoma, Islet Cell; Animals; Calcimycin; Cell Line; Clone Cells; Cricetinae; Drug Synergism; Glucagon; In Vitro Techniques; Insulinoma; Pancreatic Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1986 |
Intercellular communication of transformed and non-transformed rat liver epithelial cells. Modulation by TPA.
Topics: Animals; Cell Communication; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Epithelial Cells; Intercellular Junctions; Liver; Liver Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Protein kinase C negatively modulated by phorbol ester.
Topics: Adenosine Triphosphate; Animals; Calcium; Chlorpromazine; Diglycerides; Electrophoresis, Polyacrylamide Gel; Liver; Phorbols; Phospholipids; Phosphotransferases; Protein Kinase C; Protein Kinases; Swine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1986 |
Phorbol ester promotes growth of synaptic plasticity.
Topics: Action Potentials; Animals; Hippocampus; Neuronal Plasticity; Phorbols; Protein Kinase C; Rats; Synapses; Synaptic Transmission; Tetradecanoylphorbol Acetate | 1986 |
Effect of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on the phosphorylation of soluble acidic proteins in A431 epidermoid carcinoma cells.
Topics: Bucladesine; Carcinoma, Squamous Cell; Cells, Cultured; Cytosol; Epidermal Growth Factor; Humans; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Proteins; Tetradecanoylphorbol Acetate | 1986 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on epidermal growth factor receptors in BALB/c-3T3 cells: relationship between receptor modulation and mitogenesis.
Topics: Animals; Cell Cycle; Cell Line; Culture Media; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Insulin; Mice; Mitogens; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Phorbol ester-induced regulation of transferrin receptors in human leukemia K562 cells.
Topics: Cell Line; Cell Membrane; Humans; Kinetics; Leukemia, Myeloid; Phorbols; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1986 |
Dissociation between induction of ornithine decarboxylase and oxidative burst by phorbol esters in a macrophage cell line.
Topics: Animals; Cell Line; Enzyme Induction; Macrophages; Mice; Ornithine Decarboxylase; Oxidation-Reduction; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).
Topics: Animals; Carbachol; Cell Line; Cyclic GMP; Inositol Phosphates; Mice; Neuroblastoma; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Muscarinic; Sugar Phosphates; Tetradecanoylphorbol Acetate | 1986 |
Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets.
Topics: Adenosine Diphosphate Ribose; Blood Platelets; Glycoproteins; Hirudins; Humans; Membrane Proteins; Molecular Weight; Pertussis Toxin; Phorbols; Platelet Membrane Glycoproteins; Prostaglandin D2; Prostaglandins D; Protein Kinase C; Receptors, Cell Surface; Receptors, Thrombin; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1986 |
Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.
Topics: Animals; Carcinogens; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Mice; Mitogens; Phorbols; Phosphoproteins; Phosphorylation; Protamine Kinase; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Role of calcium on TPA-induced secretion of ACTH and PGE2 by pituitary cells: effect of dexamethasone.
Topics: Adrenocorticotropic Hormone; Animals; Calcimycin; Calcium; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Male; Phorbols; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prostaglandins E; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
DNA strand breaks in human leukocytes induced by superoxide anion, hydrogen peroxide and tumor promoters are repaired slowly compared to breaks induced by ionizing radiation.
Topics: Benzamides; Calcimycin; DNA; DNA Repair; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester-induced surface transferrin receptor modulation. No correlation with decreased cell proliferation.
Topics: Cell Division; Cell Line; Cell Membrane; Diglycerides; Diltiazem; DNA; Egtazic Acid; Humans; Phorbols; Phosphorylation; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1986 |
The effect of cAMP on tumour promoter responses mediated by C-kinase.
Topics: Aminophylline; Animals; Bucladesine; Carcinogens; Cell Communication; Cell Line; Cyclic AMP; Diglycerides; Epidermal Growth Factor; Glycerides; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylcholines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Regulation of magnesium but not calcium transport by phorbol ester.
Topics: Animals; Biological Transport, Active; Calcium; Cell Line; Colforsin; Cyclic AMP; Isoproterenol; Kinetics; Lymphoma; Magnesium; Phorbols; Phosphorylation; Tetradecanoylphorbol Acetate | 1986 |
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Isoproterenol; Oxotremorine; Phorbols; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1986 |
Activation of cyclic AMP phosphodiesterase by phorbol and protein kinase C pathway.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Enzyme Activation; In Vitro Techniques; Insulin; Kinetics; Male; Nifedipine; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1986 |
The action of phorbol ester on steroidogenesis in cultured human fetal adrenal cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Bucladesine; Cells, Cultured; Cyclic AMP; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diglycerides; Humans; Hydrocortisone; Phorbol Esters; Phorbols; Protein Kinase C; Steroid Hydroxylases; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1987 |
Calcium-dependent and -independent tumoricidal activities of polymorphonuclear leukocytes induced by a linear beta-1,3-D-glucan and phorbol myristate acetate in mice.
Topics: Adjuvants, Immunologic; Animals; Calcimycin; Calcium; Cytotoxicity, Immunologic; Egtazic Acid; Glucans; Hydrogen Peroxide; Magnesium; Male; Mice; Mice, Inbred C3H; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Extracellular calcium requirement for promotion of transformation in JB6 cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Cell Transformation, Neoplastic; Egtazic Acid; Extracellular Space; Lanthanum; Mice; Nifedipine; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Activation of IL 1-dependent and IL 1-independent T cell lines by calcium ionophore and phorbol ester.
Topics: Animals; Calcimycin; Cell Line; Dose-Response Relationship, Immunologic; Humans; Hybridomas; Interleukin-1; Interleukin-2; Leukemia P388; Lymphocyte Activation; Lymphoma; Mice; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters.
Topics: Animals; Carcinogens; Cell Compartmentation; Cell Cycle; Cell Line; Cell-Free System; Cytosol; Enzyme Activation; Lyngbya Toxins; Membrane Proteins; Mice; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Acetylcholine release from guinea pig caudate slices evoked by phorbol ester and calcium.
Topics: Acetylcholine; Aminoquinolines; Animals; Calcimycin; Calcium; Caudate Nucleus; Drug Synergism; Female; Guinea Pigs; In Vitro Techniques; Male; Phorbols; Polymyxin B; Tetradecanoylphorbol Acetate | 1986 |
Inhibitory effect of toluene on tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Drug Antagonism; Male; Mice; Mice, Inbred C3H; Phorbols; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate; Toluene | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine.
Topics: Animals; Calcium; Carnitine; Dose-Response Relationship, Drug; Egtazic Acid; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Palmitoylcarnitine; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzoquinones; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Induction; Female; Indomethacin; Isoproterenol; Kidney; Lipoxygenase Inhibitors; Liver; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Pyrazoles; Quinones; Spleen; Tetradecanoylphorbol Acetate | 1986 |
The role of prostaglandin E1 in ornithine decarboxylase induction by tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alprostadil; Animals; Diterpenes; Enzyme Induction; Female; Indomethacin; Mice; Mice, Inbred Strains; Models, Biological; Neoplasms; Ornithine Decarboxylase; Phorbols; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Role of circulating granulocytes in sheep lung injury produced by phorbol myristate acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Blood Proteins; Cardiac Output; Granulocytes; Leukopenia; Lung; Lung Injury; Lymph; Oxygen Consumption; Phorbols; Pulmonary Circulation; Pulmonary Edema; Respiratory Distress Syndrome; Sheep; Tetradecanoylphorbol Acetate; Vascular Resistance | 1986 |
Effects of a phorbol ester and diacylglycerols on secretion of mucin and arginine esterase by rat submandibular gland cells.
Topics: Animals; Calcimycin; Calcium; Carboxylic Ester Hydrolases; Diglycerides; Fluphenazine; Glycerides; Male; Mucins; Phorbols; Polymyxin B; Rats; Rats, Inbred Strains; Submandibular Gland; Tetradecanoylphorbol Acetate | 1986 |
Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.
Topics: Animals; Blood Physiological Phenomena; Chick Embryo; Cycloheximide; Enzyme Activation; Fibroblasts; Glucose; Oncogene Protein pp60(v-src); Phorbols; Phosphorylation; Protein Kinase C; Retroviridae Proteins; Ribosomal Protein S6; Ribosomal Proteins; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1986 |
Early precursor thymocytes can produce interleukin 2 upon stimulation with calcium ionophore and phorbol ester.
Topics: Animals; Antibodies, Monoclonal; Antigens, Ly; Calcimycin; Cell Differentiation; Concanavalin A; Flow Cytometry; Hematopoietic Stem Cells; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1986 |
Phorbol myristate acetate-stimulated release of cyclooxygenase products in rat pleural cells: derivatization of prostaglandins with 9-anthryldiazomethane for fluorometric determination by high performance liquid chromatography.
Topics: Animals; Anthracenes; Chromatography, High Pressure Liquid; Fluorescent Dyes; Kinetics; Leukocytes; Male; Phorbols; Pleura; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
A defect of platelet release reaction in a patient with SLE: impaired platelet aggregation induced by phorbol ester with a normal phosphorylation of 40K protein.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Calcimycin; Collagen; Diglycerides; Epinephrine; Female; Humans; Lupus Erythematosus, Systemic; Phorbols; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Calcium regulation of tissue plasminogen activator and prostaglandin biosynthesis in HeLa cells.
Topics: Calcimycin; Calcium; Dinoprostone; HeLa Cells; Humans; Kinetics; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1986 |
Phorbol ester treatment impairs hormone- but not stable GTP analog-induced inhibition of adenylate cyclase.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclase Inhibitors; Blood Platelets; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Lymphoma; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides | 1986 |
Phorbol ester and 1,2-diolein are not fully equivalent activators of protein kinase C in respect to phosphorylation of membrane proteins in vitro.
Topics: Animals; Diglycerides; Egtazic Acid; Enzyme Activation; Female; Glycerides; In Vitro Techniques; Membrane Proteins; Phorbols; Phosphatidylserines; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Reorganization of alpha-actinin and vinculin induced by a phorbol ester in living cells.
Topics: Actinin; Animals; Cell Adhesion; Cell Line; Chickens; Chlorocebus aethiops; Coloring Agents; Gizzard, Avian; Kidney; Microinjections; Muscle Proteins; Muscle, Smooth; Phorbols; Rhodamines; Tetradecanoylphorbol Acetate; Vinculin | 1986 |
Sustained IL-2 production by the EL4 subline during continuous phorbol diester stimulation is related to an increase of IL-2-mRNA.
Topics: Animals; Aphidicolin; Cell Division; Cell Line; Cyclosporins; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Interleukin-2; Lymphoma; Mice; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate | 1986 |
Calcium-independent induction of cytocidal activity of polymorphonuclear leukocytes by phorbol myristate acetate-like tumor promoters.
Topics: Animals; beta-Glucans; Calcium; Carcinogens; Cell Line; Croton Oil; Cytotoxicity, Immunologic; Egtazic Acid; Glucans; Lyngbya Toxins; Mice; Mice, Inbred C3H; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
Topics: Adenylate Cyclase Toxin; Aminoquinolines; Angiotensin II; Animals; Calcium; Diglycerides; Epidermal Growth Factor; Glycerides; GTP-Binding Proteins; Inositol Phosphates; Isoelectric Point; Liver; Male; Molecular Weight; Pertussis Toxin; Phorbols; Phosphoproteins; Rats; Sugar Phosphates; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin.
Topics: Animals; Calcium; Calmodulin; Enzyme Induction; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
[Factors controlling tumor promotion induced by TPA].
Topics: Animals; Benzoquinones; Enzyme Activation; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase; Palmitoylcarnitine; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinones; Skin Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
The effect of tetradecanoylphorbol acetate on calcium-ion mobilization, protein phosphorylation and cytoskeletal assembly induced by thrombin or arachidonate.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cytoskeleton; Ethers; Humans; Ionomycin; Myosins; Phorbols; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Potentiation and inhibition of secretion from neutrophils by phorbol ester.
Topics: Animals; Calcimycin; Calcium; Cytoplasmic Granules; Exocytosis; Glucuronidase; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Phosphatidic Acids; Phosphoproteins; Phosphorylation; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Calcium ionophore A 23 187 in the presence of phorbol ester PMA: a potent inducer of interleukin 2 and interferon-gamma synthesis by human blood cells.
Topics: Calcimycin; Calcium; Cells, Cultured; Humans; Interferon-gamma; Interleukin-2; Kinetics; Manganese; Monocytes; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
A cDNA clone used to study mRNA inducible in human tonsillar lymphocytes by a tumor promoter.
Topics: Amino Acid Sequence; Base Sequence; DNA; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-2; Lymphocytes; Palatine Tonsil; Phorbols; Phytohemagglutinins; RNA, Messenger; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate | 1986 |
Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Calcimycin; Calcium; Cell Membrane; Female; Immunoglobulin D; Immunoglobulin M; Lymphocyte Activation; Mice; Phorbols; Phosphatidylinositols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
The phorbol ester TPA induces hormone release and electrical activity in clonal rat pituitary cells.
Topics: Animals; Cell Membrane Permeability; Clone Cells; Membrane Potentials; Perfusion; Phorbols; Pituitary Gland, Anterior; Prolactin; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1986 |
Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate: dependence on calcium availability.
Topics: Animals; Autoradiography; Calcimycin; Calcium; Chemical Precipitation; Densitometry; Eflornithine; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Mice; Nucleic Acid Hybridization; Ornithine; Ornithine Decarboxylase; Phorbols; Protein Binding; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester stimulates the synthesis and phosphorylation of a 48 kDa-intracellular protein in plasminogen activator secreting melanoma cells.
Topics: Cell Line; Cytosol; Humans; Melanoma; Molecular Weight; Neoplasm Proteins; Phorbols; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1986 |
Early effects of TPA on protein kinase activity in murine thymocytes. Reduction of protein kinase C activity in the cytosol and increase of Ca2+ and phospholipid-independent kinase activity in the particulate fractions.
Topics: Animals; Cells, Cultured; Cytosol; Enzyme Activation; Interleukin-1; Lymphocyte Activation; Lyngbya Toxins; Mice; Phorbol Esters; Phorbols; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymus Gland | 1986 |
A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Choline; Diglycerides; Dogs; Glycerides; Kidney; Palmitic Acid; Palmitic Acids; Phorbols; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1986 |
Tumour promotor 12-O-tetradecanoylphorbol 13-acetate inhibits angiotensin II-induced inositol phosphate production and cytosolic Ca2+ rise in rat renal mesangial cells.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Cytosol; Glomerular Mesangium; GTP-Binding Proteins; Inositol Phosphates; Phorbols; Protein Kinase C; Rats; Receptors, Angiotensin; Sugar Phosphates; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Dimethylthiourea decreases acute lung edema in phorbol myristate acetate-treated rabbits.
Topics: Acute Disease; Animals; Cell Count; Humans; In Vitro Techniques; Kinetics; Neutrophils; Perfusion; Phorbols; Pressure; Pulmonary Artery; Pulmonary Edema; Rabbits; Tetradecanoylphorbol Acetate; Thiourea | 1986 |
Hyperthermia and phorbol ester tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Hyperthermia, Induced; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Skin Temperature; Tetradecanoylphorbol Acetate | 1986 |
Potentiation by retinoic acid of ornithine decarboxylase induction by phytohemagglutinin or phorbol 12-myristate 13-acetate in guinea pig lymphocytes.
Topics: Animals; Diterpenes; DNA; Drug Synergism; Eflornithine; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Leucine; Lymphocytes; Ornithine; Ornithine Decarboxylase; Phorbols; Phytohemagglutinins; Polyamines; Retinyl Esters; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1986 |
Phorbol ester-stimulated T lymphocytes show enhanced adhesion to human endothelial cell monolayers.
Topics: Cell Adhesion; Cells, Cultured; Endothelium; Fibroblasts; Gelatin; Humans; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Umbilical Veins | 1986 |
Phorbol ester-induced alteration of protein kinase C catalytic properties occurs at the membrane level and is not reproduced by physiological stimuli.
Topics: Animals; Carcinogens; Cell Compartmentation; Cell Line; Cell Membrane; Diglycerides; Diterpenes; Lyngbya Toxins; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Substrate Specificity; Terpenes; Tetradecanoylphorbol Acetate | 1986 |
TPA (12-O-tetradecanoylphorbol-13-acetate) enhances the central hypoglycemic action of thyrotropin-releasing hormone in mice.
Topics: Animals; Blood Glucose; Brain; Dose-Response Relationship, Drug; Hypoglycemia; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
PMA induces the ligand-independent internalization of CR1 on human neutrophils.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Membrane; Humans; Mice; Mice, Inbred BALB C; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Phorbols; Rabbits; Receptors, Complement; Receptors, Complement 3b; Tetradecanoylphorbol Acetate | 1985 |
Hydrolysis of novel diacylglycerol analogs and phorbol diesters by serum lipase.
Topics: Animals; Blood; Chromatography, Thin Layer; Diglycerides; Glycerides; Hydrolysis; Lipase; Liposomes; Male; Palmitic Acid; Palmitic Acids; Phorbols; Protein Kinase C; Protein Kinases; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate | 1985 |
Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.
Topics: Animals; Cell Line; Insulin; Liver Neoplasms, Experimental; Peptide Hydrolases; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Ribosomal Protein S6; Ribosomal Proteins; Tetradecanoylphorbol Acetate; Trypsin | 1985 |
Effects of phorbol ester on catecholamine secretion and protein phosphorylation in adrenal medullary cell cultures.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin Granules; Chromatography, Thin Layer; Digitonin; Dose-Response Relationship, Drug; Ethers; Ionomycin; Molecular Weight; Norepinephrine; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Proteins; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter 12-O-tetradecanoylphorbol-13-acetate receptors in normal human transitional epithelial cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; Humans; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium; Ureter | 1985 |
Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cell Membrane Permeability; Cells, Cultured; Chromaffin System; Digitonin; Electricity; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes.
Topics: Acetylcholine; Animals; Cells, Cultured; Chick Embryo; Electrophysiology; Enzyme Activation; Membrane Potentials; Mice; Muscles; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cholinergic; Tetradecanoylphorbol Acetate | 1985 |
Opsonic properties of C-reactive protein. Stimulation by phorbol myristate acetate enables human neutrophils to phagocytize C-reactive protein-coated cells.
Topics: Animals; C-Reactive Protein; Cell Adhesion; Dose-Response Relationship, Immunologic; Erythrocytes; Humans; Immunoglobulin G; Neutrophils; Opsonin Proteins; Phagocytosis; Phorbols; Polysaccharides, Bacterial; Rabbits; Receptors, Fc; Receptors, IgG; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol myristate acetate and in vitro T lymphocyte function. III. Selective impairment by PMA of lethal hit delivery by cloned CTL.
Topics: Animals; Antigens, Ly; Cell Line; Clone Cells; Cytotoxicity, Immunologic; Female; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mice; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells.
Topics: Animals; Lymphoma; Methionine; Mice; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Retinaldehyde; Tetracaine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Surface antigen expression by a human B-lymphoblastoid cell line treated with 'differentiation' inducers, dimethysulfoxide and tetradecanoylphorbol acetate.
Topics: Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Cell Cycle; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Histocompatibility Antigens Class II; HLA Antigens; Humans; Neprilysin; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1985 |
Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.
Topics: Animals; Bacterial Toxins; GTP-Binding Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phorbol Esters; Phorbols; Phospholipids; Protein Kinase C; Protein Kinases; Rabbits; Sodium; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1985 |
Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity.
Topics: Animals; B-Lymphocytes; Calcium; Cell Membrane; Cell Membrane Permeability; Electrophysiology; Glucose; Glyburide; Male; Membrane Potentials; Mice; Mice, Inbred CBA; Phorbols; Potassium; Protein Kinase C; Protein Kinases; Putrescine; Spermidine; Tetradecanoylphorbol Acetate | 1985 |
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Glucose; Insulin; Male; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1985 |
Forskolin and 12-0-tetradecanoylphorbol-13-acetate mimic thyrotropin-stimulated protein iodination in mouse thyroid.
Topics: Adenylyl Cyclases; Animals; Colforsin; Diterpenes; Female; Iodine; Mice; Phorbols; Protein Kinase C; Protein Kinases; Proteins; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1985 |
Phorbol ester provokes insulin-like effects on glucose transport, amino acid uptake, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes.
Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Diglycerides; Glucose; Insulin; Muscles; Phorbols; Protein Kinase C; Protein Kinases; Pyruvate Dehydrogenase Complex; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Epidermis; Female; Mice; Mice, Inbred ICR; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Enhancement in the activities of mouse epidermal glucose-6-phosphate dehydrogenase, hexokinase, phosphofructokinase, and pyruvate kinase by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Enzyme Activation; Epidermis; Glucose; Glucosephosphate Dehydrogenase; Hexokinase; Male; Mice; Phorbols; Phosphofructokinase-1; Pyruvate Kinase; Rats; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Cell-free system studies on the phosphorylation of the 17,000-20,000 dalton protein induced by phorbol ester in human leukemic cells and evidence for a similar event in virally transformed murine fibroblasts.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cell-Free System; Cytosol; Fibroblasts; Humans; Kirsten murine sarcoma virus; Leukemia, Myeloid, Acute; Mice; Molecular Weight; Neoplasm Proteins; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Trypsin | 1985 |
Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism.
Topics: Antibodies, Monoclonal; Binding, Competitive; Cytochalasin B; Cytoskeleton; Fibronectins; Humans; Immunoglobulin Fab Fragments; Neutrophils; Phagocytosis; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Receptors, Complement; Receptors, Complement 3b; Temperature; Tetradecanoylphorbol Acetate | 1985 |
The phorbol ester TPA enhances A23187--but not carbachol- and high K+-induced catecholamine secretion from cultured bovine adrenal chromaffin cells.
Topics: Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Phorbols; Potassium; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Rapid inhibition of intercellular communication between BALB/c 3T3 cells by diacylglycerol, a possible endogenous functional analogue of phorbol esters.
Topics: Animals; Cell Communication; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Glycerides; Isoquinolines; Mice; Mice, Inbred BALB C; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Dual actions of phorbol esters on cytosolic free Ca2+ concentrations and reconstitution with ionomycin of acute thyrotropin-releasing hormone responses.
Topics: Animals; Anti-Bacterial Agents; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cells, Cultured; Cytosol; Diterpenes; Egtazic Acid; Epidermal Growth Factor; Ethers; Insulin; Ionomycin; Phorbols; Pituitary Gland; Potassium; Protein Kinase C; Protein Kinases; Rats; Receptors, Drug; Receptors, Immunologic; Terpenes; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |
Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.
Topics: Alkaline Phosphatase; Cell Compartmentation; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Evidence that treatment of platelets with phorbol ester causes proteolytic activation of Ca2+-activated, phospholipid-dependent protein kinase.
Topics: Blood Platelets; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Enzyme Activation; Humans; Peptide Hydrolases; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Dinoprostone; Female; Isoquinolines; Kidney Glomerulus; Phorbol Esters; Phorbols; Piperazines; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Characterization of lymphocyte stimulation by phorbol related compounds.
Topics: Adolescent; Adult; Animals; Humans; Irritants; Lymphocyte Activation; Male; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phytohemagglutinins; Skin Tests; Tetradecanoylphorbol Acetate | 1988 |
The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.
Topics: Actins; Animals; Cell Line; Cell Transformation, Viral; Collagen; Gene Expression Regulation; Glycoproteins; Lysosomes; Membrane Glycoproteins; Mice; Oncogenes; Phorbols; Phosphoproteins; Platelet-Derived Growth Factor; Protein Biosynthesis; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tubulin | 1986 |
Cell differentiation and cell cycle effects on human promyelocytic leukemia cells induced by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Cycle; Cell Differentiation; Cell Line; Flow Cytometry; Histocytochemistry; Humans; Isoenzymes; L-Lactate Dehydrogenase; Leukemia, Myeloid, Acute; Mitosis; Nitroblue Tetrazolium; Oxidation-Reduction; Phagocytosis; Phenotype; Phorbols; Receptors, Fc; Tetradecanoylphorbol Acetate | 1986 |
Partial purification and characterization of phorbol ester-regulated translational inhibitor(s) in human HL-60 leukemic cells.
Topics: Animals; Cell Extracts; Cell Line; Chromatography; Electrophoresis, Polyacrylamide Gel; Eukaryotic Initiation Factor-2; Fructosephosphates; Globins; Humans; Kinetics; Leukemia, Myeloid; Peptide Initiation Factors; Phorbols; Phosphorylation; Protein Biosynthesis; Proteins; Rabbits; Reticulocytes; RNA, Messenger; Tetradecanoylphorbol Acetate | 1986 |
Phorbol diester-induced phosphorylation of nuclear matrix proteins in HL60 promyelocytes. Possible role in differentiation studied by cationic detergent gel electrophoresis.
Topics: Antigens, Nuclear; Autoantibodies; Autoradiography; Cell Adhesion; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Leukemia, Myeloid, Acute; Nucleoproteins; Phorbols; Phosphorus Radioisotopes; Phosphorylation; Tetradecanoylphorbol Acetate | 1986 |
Prostaglandin E and thromboxane B2 release by PMA-induced U937 cells in response to C3b.
Topics: Cell Differentiation; Cell Line; Complement C3b; Culture Media; Dose-Response Relationship, Drug; Humans; Monocytes; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate; Thromboxane B2; Time Factors | 1986 |
Protein kinase C and phorbol ester receptor expression related to growth and differentiation of nullipotent and pluripotent embryonal carcinoma cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Division; Cell Line; DNA Replication; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Teratoma; Tetradecanoylphorbol Acetate; Thymidine | 1986 |
1-Oleoyl 2-acetyl glycerol inhibits differentiation of TPA-sensitive but not of TPA-resistant Friend cells.
Topics: Acetamides; Animals; Cell Adhesion; Cell Differentiation; Diglycerides; Dose-Response Relationship, Drug; Drug Resistance; Friend murine leukemia virus; Glycerides; Leukemia, Erythroblastic, Acute; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Inability of HL-60 cells induced by phorbol myristate acetate to produce macrophage-associated glycosaminoglycans.
Topics: Cell Line; Glycosaminoglycans; Humans; Kinetics; Leukemia, Myeloid, Acute; Macrophages; Phorbols; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate | 1986 |
Bacterial lipopolysaccharides, phorbol myristate acetate, and zymosan induce the myristoylation of specific macrophage proteins.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hydroxylamine; Hydroxylamines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred ICR; Molecular Weight; Myristic Acid; Myristic Acids; Phorbols; Proteins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1986 |
Dimethylsulfoxide, retinoic acid and 12-O-tetradecanoylphorbol-13-acetate induce a selective decrease in the phosphorylation of P150, a surface membrane phosphoprotein of HL60 cells resistant to adriamycin.
Topics: Dimethyl Sulfoxide; Doxorubicin; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Myeloid, Acute; Membrane Proteins; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C.
Topics: Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Loss of intercalated membrane particles by treatment with phorbols.
Topics: Cell Membrane; Freeze Fracturing; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters inhibit ammoniagenesis and gluconeogenesis in proximal tubular segments.
Topics: Ammonia; Animals; Dimethyl Sulfoxide; Dogs; Gluconeogenesis; Glutamine; Kidney Tubules, Proximal; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1987 |
Mimicry of phorbol ester responses by diacylglycerols. Differential effects on phosphatidylcholine biosynthesis, cell-cell communication and epidermal growth factor binding.
Topics: Animals; Cell Communication; Cell Line; Diglycerides; Epidermal Growth Factor; Epidermis; Glycerides; Intercellular Junctions; Mice; Phorbols; Phosphatidylcholines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Activation and proliferation signals in mouse B cells. VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate.
Topics: Animals; Antibody Formation; B-Lymphocytes; DNA; Drug Synergism; Ethers; Female; Growth Substances; Histocompatibility Antigens Class II; Interleukin-4; Ionomycin; Lymphocyte Activation; Lymphokines; Male; Mice; Mice, Inbred Strains; Phorbols; Phosphatidylinositols; Tetradecanoylphorbol Acetate | 1986 |
Lymphocyte activation by OKT3: cyclosporine sensitivity and synergism with phorbol ester.
Topics: Antibodies, Monoclonal; Calcium; Concanavalin A; Cyclosporins; Drug Synergism; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Lymphocyte Activation; Lymphocytes; Methionine; Phorbols; Phytohemagglutinins; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Phenotypic modulation of T-lymphoblastic leukaemic cells with phorbol ester and leucocyte conditioned medium.
Topics: Adult; Antibodies, Monoclonal; Cell Line; Female; Fetal Blood; Humans; Immunoglobulin G; Leukemia, Lymphoid; Lymphocytes; Phenotype; Phorbols; Pregnancy; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Biological Transport; Calcium; Cell Membrane; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; Lymphocyte Activation; Phorbols; Phospholipids; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Alteration in glycosphingolipid pattern during phorbol-12-myristate-13-acetate-induced cell differentiation in human T-lymphoid leukemia cells.
Topics: Antibodies, Monoclonal; Cell Differentiation; G(M3) Ganglioside; Gangliosides; Glycosphingolipids; Humans; Leukemia, Lymphoid; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate.
Topics: Animals; Cell Line; Diglycerides; Epidermal Growth Factor; Fibroblasts; Glycerides; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Hairy cell leukaemia: effects of phorbol ester on cell morphology and adherence and comparison with other B-cell neoplasias.
Topics: B-Lymphocytes; Cell Adhesion; Humans; Leukemia, Hairy Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Microscopy, Electron; Microscopy, Electron, Scanning; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C.
Topics: Cell Compartmentation; Cytosol; Humans; In Vitro Techniques; Kinetics; Lymphocyte Activation; Membranes; Phorbols; Phytohemagglutinins; Protein Kinase C; Solubility; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Immunodeficiency of aging: restorative effects of phorbol ester combined with calcium ionophore.
Topics: Aging; Animals; DNA; Dose-Response Relationship, Immunologic; Drug Combinations; Ethers; Immunologic Deficiency Syndromes; Interphase; Ionomycin; Ionophores; Lymphocyte Activation; Mice; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Secretory leukemic B cells express T cell markers in vitro. A phenomenon suppressed by TPA.
Topics: Antigens, Surface; B-Lymphocytes; Cell Differentiation; Humans; Immunoglobulin M; In Vitro Techniques; Isoenzymes; L-Lactate Dehydrogenase; Leukemia; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester.
Topics: Action Potentials; Cell Adhesion; Cell Division; Cells, Cultured; Humans; Kinetics; Phorbols; Potassium; Quinine; Sensory Thresholds; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1986 |
Topical application of a tumor promoter induces proliferation of an adherent cell population in murine spleen.
Topics: Administration, Topical; Animals; B-Lymphocytes; Cell Adhesion; Cell Separation; DNA Replication; Female; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbols; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester-induced production of beta-2-microglobulin in B-CLL cells: relation to IgM secretory response and disease activity.
Topics: Adolescent; Adult; Aged; B-Lymphocytes; beta 2-Microglobulin; Cells, Cultured; Child; Female; Humans; Immunoglobulin M; Leukemia, Lymphoid; Male; Middle Aged; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Characterization of the formyl peptide chemotactic receptor appearing at the phagocytic cell surface after exposure to phorbol myristate acetate.
Topics: Affinity Labels; Autoradiography; Cell Line; Chemotactic Factors; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-8; Membrane Proteins; Neutrophils; Oligopeptides; Phagocytosis; Phorbols; Receptors, Formyl Peptide; Receptors, Immunologic; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1986 |
Expression of MHC class II antigens in human B-cell leukaemia, and increased levels of class II antigens and DR-specific mRNA after stimulation with 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Antibodies, Monoclonal; Antigens, Surface; B-Lymphocytes; Cells, Cultured; Fluorescent Antibody Technique; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leukemia, Lymphoid; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Enhancement of selective tumor cell binding by activated murine macrophages in response to phorbol myristate acetate.
Topics: Animals; Cell Adhesion; Cell Line; Cytoskeleton; Hydrogen Peroxide; Kinetics; Macrophage Activation; Macrophages; Mice; Mycobacterium bovis; Neoplasms, Experimental; Phorbols; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Trypsin | 1986 |
Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.
Topics: Animals; Calcium; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Phorbols; Rats; Rats, Inbred Strains; Temperature; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters, but not insulin, promote depletion of cytosolic protein kinase C in rat adipocytes.
Topics: Adipose Tissue; Animals; Cell Compartmentation; Cell Membrane; Cytosol; Enzyme Activation; Insulin; Male; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1986 |
Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells.
Topics: Cell Compartmentation; Cell Line; Cell Membrane; Cytosol; Humans; Immunoenzyme Techniques; Immunosorbent Techniques; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cations, Divalent; Cell Adhesion; Cell Line; Cell Movement; Humans; Immunologic Capping; Leukocytes; Lymphocyte Function-Associated Antigen-1; Lymphocytes; Macrophage-1 Antigen; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Differential effects of phorbol esters on normal myeloid precursors and leukemic cells: basis for autologous bone marrow reconstitution in acute nonlymphocytic leukemia using phorbol ester-treated bone marrow from patients in remission.
Topics: Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cell Cycle; Cell Differentiation; Cells, Cultured; Colony-Forming Units Assay; Combined Modality Therapy; Dose-Response Relationship, Drug; Freezing; Hematopoiesis; Humans; Karyotyping; Leukemia; Leukemia, Myeloid, Acute; Phorbols; Preservation, Biological; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Induction of vimentin synthesis in mouse myeloma cells MPC-11 by 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Line; Fluorescent Antibody Technique; Gene Expression Regulation; Kinetics; Mice; Phorbols; Plasmacytoma; Protein Biosynthesis; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Vimentin | 1986 |
Lung vascular injury after Escherichia coli endotoxin and phorbol myristate acetate infusion in dogs.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Endotoxins; Escherichia coli; Female; Infusions, Parenteral; Kinetics; Lung; Male; Neutrophils; Oxygen; Partial Pressure; Phorbols; Pulmonary Circulation; Tetradecanoylphorbol Acetate | 1986 |
Stimulation of insulin release by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the clonal cell line RINm5F despite a lowering of the free cytoplasmic Ca2+ concentration.
Topics: Animals; Calcium; Cell Line; Cytoplasm; Inositol Phosphates; Insulin; Insulin Secretion; Membrane Potentials; Phorbols; Protein Kinase C; Rats; Secretory Rate; Tetradecanoylphorbol Acetate | 1986 |
Phosphorylation of histones is stimulated by phorbol esters in quiescent Reuber H35 hepatoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate Ribose; Alkaline Phosphatase; Animals; Cell Line; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Histones; Insulin; Liver Neoplasms, Experimental; Phorbols; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Rats; Tetradecanoylphorbol Acetate | 1986 |
Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose.
Topics: Animals; Biological Transport, Active; Cell Line; Ceramides; Deoxy Sugars; Deoxyglucose; Fibroblasts; Insulin; Insulin Antagonists; Mice; Phorbols; Sphingolipids; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 1986 |
ATP induces the release of a neutral serine proteinase and enhances the production of superoxide anion in membranes from phorbol ester-activated neutrophils.
Topics: Adenosine Triphosphate; Cell Membrane; Endopeptidases; Humans; Hydrogen-Ion Concentration; Kinetics; Neutrophils; Phorbols; Retinaldehyde; Serine Endopeptidases; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters, but not epidermal growth factor or insulin, rapidly decrease soluble protein kinase C activity in rat hepatocytes.
Topics: Animals; Cell Compartmentation; Cells, Cultured; Epidermal Growth Factor; Histones; Insulin; Liver; Male; Phorbols; Protein Kinase C; Rats; Solubility; Tetradecanoylphorbol Acetate | 1986 |
Insulin and phorbol esters affect the maximum velocity rather than the half-saturation constant of 3-O-methylglucose transport in rat adipocytes.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Insulin; Kinetics; Male; Methylglucosides; Methylglycosides; Monosaccharide Transport Proteins; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Effect of phorbol ester on rat liver regeneration.
Topics: Animals; Cell Division; DNA Replication; Liver; Liver Regeneration; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1987 |
[Effect of the tumor-growth promoter 12-O-tetradecanoylphorbol-13-acetate on the proliferation of different clones of mouse tumor cells in a semiliquid medium].
Topics: Animals; Cell Transformation, Neoplastic; Clone Cells; Colchicine; Culture Media; Fibroblasts; Gene Amplification; Methylcellulose; Mice; Mice, Inbred AKR; Mice, Inbred CBA; Phorbols; Sarcoma, Experimental; Tetradecanoylphorbol Acetate | 1986 |
[Enhancement of the transforming activity of simian adenovirus S5 and of the DNA from human adenovirus type I by benzo(a)pyrene and TPA].
Topics: Adenoviridae; Adenoviruses, Human; Adenoviruses, Simian; Animals; Animals, Newborn; Benzo(a)pyrene; Cell Line; Cell Transformation, Viral; Cells, Cultured; Chlorocebus aethiops; Cricetinae; DNA, Viral; Humans; Kidney; Mesocricetus; Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Separation from protein kinase C--a calcium-independent TPA-activated phosphorylating system.
Topics: Animals; Brain; Calcium; Enzyme Activation; Kinetics; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1986 |
A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis.
Topics: Chemotaxis, Leukocyte; Concanavalin A; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phagocytosis; Phorbols; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Endothelial diaphragmed fenestrae: in vitro modulation by phorbol myristate acetate.
Topics: Adrenal Cortex; Animals; Cattle; Cells, Cultured; Endothelium; Freeze Fracturing; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Ionizing radiation as an initiator in the mouse two-stage model of skin tumor formation.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; X-Rays | 1986 |
Phorbol esters modulate thrombin-operated calcium mobilisation and dense granule release in human platelets.
Topics: Blood Platelets; Calcium; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Phorbols; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Activation by phorbol esters of protein kinase C in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Chromatography, DEAE-Cellulose; Cytosol; Enzyme Activation; Female; Humans; Phorbols; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1986 |
Inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate on acid secretion by rat stomach in vivo.
Topics: Animals; Carbachol; Enzyme Activation; Gastric Acid; Gastric Mucosa; Histamine; Male; Pentagastrin; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester- and Ca2+-dependent phosphorylation of human red cell membrane skeletal proteins.
Topics: Calcium; Cytosol; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Membrane Proteins; Molecular Weight; Phorbols; Phosphates; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate and regulatory diacylglycerols are substrates for the same carboxylesterase.
Topics: Animals; Carbon Radioisotopes; Carboxylic Ester Hydrolases; Diglycerides; Glycerides; Kinetics; Lipase; Liver; Male; Microsomes, Liver; Phorbols; Rats; Rats, Inbred Strains; Substrate Specificity; Tetradecanoylphorbol Acetate; Tritium | 1986 |
Phorbol myristate acetate lung injury and airway responsiveness to aerosol histamine in awake sheep.
Topics: Aerosols; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Immunologic; Histamine; Leukocyte Count; Phorbols; Pulmonary Artery; Respiratory Distress Syndrome; Respiratory Function Tests; Sheep; Tetradecanoylphorbol Acetate | 1986 |
Stimulation of fatty acid synthesis by 4 beta-phorbol-12-myristate-13-acetate in isolated rat hepatocytes.
Topics: Animals; Calcium; Fatty Acids; In Vitro Techniques; Kinetics; Liver; Male; Phorbols; Rats; Rats, Inbred Strains; Stereoisomerism; Tetradecanoylphorbol Acetate | 1986 |
Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046.
Topics: Acrylates; Animals; Capillary Permeability; Dogs; Leukocyte Count; Lung; Methacrylates; Perfusion; Phorbols; Platelet Count; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Time Factors; Vascular Resistance; Verapamil | 1986 |
Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbolacetate.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Electrochemistry; Free Radicals; Granulocytes; Humans; Hydroxylation; In Vitro Techniques; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Phorbol esters induce both intracellular translocation and down-regulation of protein kinase C in MCF-7 cells.
Topics: Biological Transport; Cell Compartmentation; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Phorbols; Protein Kinase C; Protein Kinases; Solubility; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Stimulation of Na+/phosphate cotransport in LLC-PK1 cells by 12-O-tetradecanoylphorbol 13-acetate (TPA).
Topics: Alanine; Animals; Biological Transport; Cell Cycle; Cell Line; Cell-Free System; Cycloheximide; Kidney; Kinetics; Phorbol Esters; Phorbols; Phosphates; Protein Biosynthesis; Sodium; Stimulation, Chemical; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1986 |
Activation of protein kinase C by ganglioside GM3 in the presence of calcium and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Brain; Calcium; Enzyme Activation; G(M3) Ganglioside; Gangliosides; Kinetics; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1986 |
The effect of phorbol esters on the chloride secreting epithelium of the rabbit cornea.
Topics: Animals; Biological Transport; Chlorides; Cornea; Electrophysiology; Enzyme Activation; Epinephrine; Epithelium; In Vitro Techniques; Ions; Phorbols; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester inhibition of vasopressin-induced calcium efflux from cultured rat aortic myocytes.
Topics: Animals; Aorta, Thoracic; Arginine Vasopressin; Calcium; Cells, Cultured; Female; Muscle, Smooth, Vascular; Phorbols; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Promoting effect of 12-O-tetradecanoylphorbol-13-acetate on the in vitro malignant transformation of fetal rat brain cells exposed in utero to ethylnitrosourea.
Topics: Animals; Brain Neoplasms; Cell Aggregation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Concanavalin A; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Maternal-Fetal Exchange; Neoplasm Transplantation; Neoplastic Stem Cells; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate | 1986 |
Human glycophorin A and B are encoded by separate, single copy genes coordinately regulated by a tumor-promoting phorbol ester.
Topics: Amino Acid Sequence; Base Sequence; DNA; Electrophoresis, Agar Gel; Gene Expression Regulation; Glycophorins; Humans; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate | 1986 |
Action of phorbol myristate acetate (PMA) at fertilization of mouse oocytes in vitro.
Topics: Animals; Cell Division; Fertilization in Vitro; Mice; Oocytes; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Induction of cytoskeletal vimentin and actin gene expression by a tumor-promoting phorbol ester in the human leukemic cell line K562.
Topics: Actins; Cell Line; Cytoskeleton; DNA; Gene Expression Regulation; Humans; Leukemia; Methionine; Nucleic Acid Hybridization; Phorbols; Protein Biosynthesis; RNA, Messenger; Tetradecanoylphorbol Acetate; Vimentin | 1985 |
Intracellular localization of 12-O-3-N-dansylamino TPA in C3H/10T1/2 mouse cell line.
Topics: Animals; Cell Line; Dansyl Compounds; Fibroblasts; Fluorescence; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1985 |
Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells.
Topics: Animals; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Peptide Biosynthesis; Peptide PHI; Phorbols; Protein Precursors; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Vasoactive Intestinal Peptide | 1985 |
Regulation of glycophorin gene expression by a tumor-promoting phorbol ester in human leukemic K562 cells.
Topics: Cell Line; Genes; Glucosamine; Glycophorins; Humans; Kinetics; Leukemia, Myeloid, Acute; Methionine; Molecular Weight; Phorbols; Sialoglycoproteins; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tritium | 1985 |
Phorbol esters increase calcitonin gene transcription and decrease c-myc mRNA levels in cultured human medullary thyroid carcinoma.
Topics: Calcitonin; Carcinogens; Cell Line; DNA; Genes; Humans; Kinetics; Oncogenes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transcription, Genetic | 1985 |
Structural correlations of phorbol-ester-induced stimulation of PGE2 production by human rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Dinoprostone; Humans; Phorbol Esters; Phorbols; Prostaglandins E; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Increased glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Count; Cell Differentiation; Cell Line; Cytosol; DNA, Neoplasm; Humans; Leukemia, Myeloid; Macrophages; Phenotype; Phorbols; Receptors, Glucocorticoid; Receptors, Steroid; Tetradecanoylphorbol Acetate | 1985 |
Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Fibrosarcoma; Immune Tolerance; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1985 |
Effects of 1-beta-D-arabinofuranosylcytosine and phorbol ester on differentiation of human K562 erythroleukemia cells.
Topics: Cell Differentiation; Cell Line; Cytarabine; DNA Replication; Globins; Glycophorins; Heme; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
In vitro induction of human skin ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Amputation, Surgical; Biopsy; Carcinogens; Enzyme Induction; Epidermis; Humans; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1985 |
Induction of a novel nuclear protein (p54) by phorbol esters in mouse erythroleukemia (Friend) cells.
Topics: Animals; Cell Differentiation; Cell Line; Drug Resistance; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Methionine; Mice; Nucleoproteins; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Comparative effects of a complete tumor promoter, TPA, and a second-stage tumor promoter, RPA, on intercellular communication, cell differentiation and cell transformation.
Topics: Animals; Cell Communication; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Mice, Inbred BALB C; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Specific protein phosphorylation in human promyelocytic HL-60 leukemia cells susceptible or resistant to induction of cell differentiation by phorbol-12-myristate-13-acetate.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Differentiation; Cell Line; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Molecular Weight; Neoplasm Proteins; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1985 |
Characterization of the growth inhibition induced by tumor-promoting phorbol esters and of their receptor binding in A549 human lung carcinoma cells.
Topics: Caenorhabditis elegans Proteins; Carcinoma; Carrier Proteins; Cell Division; Cells, Cultured; Humans; Lung Neoplasms; Male; Middle Aged; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1985 |
Glucocorticoid-mediated increases in glycerol phosphate dehydrogenase activity is inhibited by the phorbol ester tumor promoters.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Dexamethasone; Enzyme Induction; Glioma; Glycerolphosphate Dehydrogenase; Oligodendroglia; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Theophylline | 1985 |
Role of prostanoids and lipid peroxides as mediators of the 12-O-tetradecanoylphorbol-13-acetate effect on cell growth.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Cell Count; Cell Division; Cells, Cultured; Dinoprostone; Fibroblasts; Guinea Pigs; Humans; Lipid Peroxides; Malondialdehyde; Muscle, Smooth; Phorbols; Prostaglandins; Prostaglandins E; Tetradecanoylphorbol Acetate | 1985 |
Positive and negative regulation of specific gene expression by the tumor promoter TPA in human erythroleukemic K562 cells.
Topics: Actins; Cell Line; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Glycophorins; Humans; Leukemia, Erythroblastic, Acute; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Vimentin | 1985 |
Cellular uptake and localization of fluorescent derivatives of phorbol ester tumor promoters.
Topics: Animals; Binding, Competitive; Cattle; Cell Line; Chick Embryo; Cytoplasm; Dansyl Compounds; Enzyme Activation; Fluorescent Dyes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activities in CD-1 and Sencar mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Isotretinoin; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Retinoids; Skin; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Female; Fibroblasts; Humans; Kinetics; Male; Melanoma; Osteosarcoma; Phorbols; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The 65-kDa phorbol-diester hydrolase in mouse plasma is esterase 1 and is immunologically distinct from the 56-kDa phorbol-diester hydrolase in mouse liver.
Topics: Animals; Antibody Specificity; Carboxylesterase; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cross Reactions; Estradiol; Kinetics; Liver; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Multiplication of human fetal myelomonocytic precursors in medium conditioned by acute myelocytic leukemia cells treated by 12-O-tetradecanoyl phorbol 13-acetate (TPA).
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Colony-Forming Units Assay; Culture Media; Culture Techniques; Fetus; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Reversal of phorbol ester-mediated reduction of cloned T lymphocyte cytolysis by interleukin 2.
Topics: Animals; Cell Line; Cells, Cultured; Cytotoxicity, Immunologic; Interleukin-2; Kinetics; Mice; Mice, Inbred Strains; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Co-mitogenic tumor promoters suppress the phosphatidylinositol response in lymphocytes during early mitogenesis.
Topics: Animals; Carcinogens; Female; Humans; Lymphocyte Activation; Mice; Phorbol Esters; Phorbols; Phosphates; Phosphatidylcholines; Phosphatidylinositols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Phorbol ester-induced differentiation of chronic B lymphocytic leukaemia cells--regulatory impact of autologous and allogeneic accessory cells.
Topics: Aged; Antibodies, Monoclonal; Antigen-Presenting Cells; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Female; Humans; Immunoglobulin M; Leukemia, Lymphoid; Male; Middle Aged; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Induction and characterization of lymphotoxins from tumor promoter-synergized, lectin-stimulated human lymphocytes in vitro.
Topics: Carcinogens; Chromatography, Affinity; Chromatography, Ion Exchange; Diterpenes; Humans; In Vitro Techniques; Lymphocytes; Lymphotoxin-alpha; Phorbol Esters; Phorbols; Phytohemagglutinins; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
LPF-induced T cell colony formation: effect of PMA and interleukin-2, and surface marker analysis.
Topics: Antigens, Surface; B-Lymphocytes; Bacterial Toxins; Clone Cells; Humans; In Vitro Techniques; Interleukin-2; Leukocyte Count; Monocytes; Pertussis Toxin; Phenotype; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1985 |
The modulation of growth of normal rat liver epithelial cells in calcium-poor medium by epidermal growth factor, phenobarbital, phorbol ester, and retinoic acid.
Topics: Animals; Calcium; Cell Division; Cell Line; Cell Survival; Culture Media; Epidermal Growth Factor; Epithelial Cells; Epithelium; Liver; Phenobarbital; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.
Topics: Blood Platelets; Calcium; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Phorbols; Phosphorylation; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1985 |
Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.
Topics: Animals; B-Lymphocytes; Calcium; Cell Differentiation; Cell Line; Kinetics; Lipopolysaccharides; Lymphocyte Activation; Mice; Monensin; Phorbols; Phosphatidylinositols; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Modulation of type-IV procollagen and laminin production in A431 human squamous epidermoid carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF).
Topics: Basement Membrane; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Line; Drug Synergism; Epidermal Growth Factor; Epithelium; Extracellular Matrix; Humans; Laminin; Neoplasm Proteins; Phorbols; Procollagen; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol diesters stimulate the development of an early murine progenitor cell. The burst-forming unit-megakaryocyte.
Topics: Animals; Centrifugation, Density Gradient; Colony-Stimulating Factors; Kinetics; Male; Megakaryocytes; Mice; Mice, Inbred C57BL; Phorbols; Stem Cells; Tetradecanoylphorbol Acetate | 1985 |
Tpa-induced maturation in secretory human B-leukemic cells in vitro: DNA synthesis, antigenic changes, and immunoglobulin secretion.
Topics: Aged; Antigens, Surface; B-Lymphocytes; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Growth Substances; Humans; Immunoglobulin M; Immunoglobulins; Leukemia; Male; Neoplastic Stem Cells; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Growth of human bone marrow in vitro.
Topics: Bone Marrow Cells; Cell Division; Cells, Cultured; Colony-Stimulating Factors; Culture Media; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Macrophages; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Correlation of murine susceptibility to tumor, parasite and bacterial challenge with altered cell-mediated immunity following systemic exposure to the tumor promoter phorbol myristate acetate.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Listeriosis; Macrophage Activation; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Trichinellosis | 1985 |
Role of phorbol ester receptors in the 12-0-tetradecanoyl-phorbol-13-acetate (TPA)-induced down-regulation of colony-stimulating factor (CSF-1) binding to murine peritoneal exudate macrophages.
Topics: Animals; Ascitic Fluid; Caenorhabditis elegans Proteins; Carrier Proteins; Colony-Stimulating Factors; Macrophages; Mice; Mice, Inbred C3H; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Signals involved in T cell activation. I. Phorbol esters enhance responsiveness but cannot replace intact accessory cells in the induction of mitogen-stimulated T cell proliferation.
Topics: Adjuvants, Immunologic; Animals; Antigen-Presenting Cells; DNA; Guinea Pigs; Immunosuppressive Agents; Interleukin-1; Interleukin-2; Lymphocyte Activation; Macrophages; Mitogens; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes.
Topics: B-Lymphocytes; Cell Differentiation; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Molecular Weight; Phorbols; Phosphorylation; Polyethylene Glycols; Solubility; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Phorbol myristate acetate-protein complex mimics bioactivity of human IL-1. 1. Direct evidence that PMA temporarily enters and is released from cellular compartment during superinduction protocol.
Topics: Animals; Binding, Competitive; Cell Compartmentation; Cell Line; Dinoprostone; Humans; Immune Sera; Interleukin-1; Leukemia P388; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Proteins; Phorbols; Phytohemagglutinins; Prostaglandins E; Pyrogens; Rabbits; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester induces a differential effect on the effector function of human allospecific cytotoxic T lymphocyte and natural killer clones.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Division; Cytotoxicity, Immunologic; Histocompatibility Antigens; Humans; Interleukin-2; Killer Cells, Natural; Phorbols; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1985 |
Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters.
Topics: Adenylyl Cyclases; Animals; Carcinogens; Erythrocyte Membrane; Erythrocytes; Fluorides; Isoproterenol; Kinetics; Manganese; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rana pipiens; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Dual effect of phorbol myristate acetate (PMA) on murine thymocyte cultures.
Topics: Animals; Cells, Cultured; Interleukin-1; Kinetics; Lymphocyte Activation; Mercaptoethanol; Mice; Phorbols; Sulfhydryl Compounds; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Phorbol myristate acetate--fate and usability in a human interleukin-1 assay.
Topics: Biological Assay; Cells, Cultured; Culture Media; Humans; Interleukin-1; Lymphocyte Activation; Macrophages; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1985 |
Selective effects of TPA and IL-1 on protein phosphorylation in murine thymocytes.
Topics: Animals; Chlorpromazine; Diglycerides; Enzyme Activation; Interleukin-1; Lectins; Lidocaine; Mice; Molecular Weight; Peanut Agglutinin; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1985 |
Phorbol ester effect in platelets, lymphocytes, and leukemic cells (HL-60) is associated with enhanced phosphorylation of class I HLA antigens. Coprecipitation of myosin light chain.
Topics: Blood Platelets; Cell Line; Electrophoresis, Polyacrylamide Gel; HLA Antigens; Humans; Immunosorbent Techniques; Leukemia, Myeloid, Acute; Lymphocytes; Phorbols; Phosphorylation; Tetradecanoylphorbol Acetate | 1985 |
Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.
Topics: Adipose Tissue; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Insulin; Lipids; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate enhances the long-term maintenance of pancreatic islet B cell differentiated function in tissue culture.
Topics: Animals; Cell Differentiation; Culture Techniques; Insulin; Islets of Langerhans; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.
Topics: Adipose Tissue; Animals; Cell Line; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Enzyme Activation; Insulin; Mice; Phorbols; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Insulin and phorbol ester stimulate phosphorylation of a 40-kDa protein in adipocyte plasma membranes.
Topics: Adipose Tissue; Animals; Cell Membrane; Diglycerides; Insulin; Kinetics; Male; Membrane Proteins; Molecular Weight; Phorbols; Phosphatidylserines; Phosphoproteins; Phosphorylation; Rats; Tetradecanoylphorbol Acetate | 1985 |
Stimulation and inhibition of Leydig cell steroidogenesis by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate: similarity to the effects of gonadotropin-releasing hormone.
Topics: Androgens; Animals; Gonadotropin-Releasing Hormone; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Emergence of TPA-resistant 'satellite' cells during muscle histogenesis of human limb.
Topics: Adolescent; Adult; Biopsy; Bungarotoxins; Cell Differentiation; Cells, Cultured; Drug Resistance; Female; Gestational Age; Histocytochemistry; Humans; Immunologic Techniques; Leg; Middle Aged; Muscles; Myosins; Phorbols; Pregnancy; Receptors, Cholinergic; Tetradecanoylphorbol Acetate | 1985 |
Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Permeability; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1985 |
Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.
Topics: Animals; Brain; Cell Line; Cell Membrane; Cytosol; Half-Life; Immune Sera; Immunosorbent Techniques; Methionine; Phorbols; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.
Topics: Animals; Bryostatins; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cells, Cultured; Insulin; Lactones; Macrolides; Mice; Mitogens; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Arachidonic acid release and catecholamine secretion from digitonin-treated chromaffin cells: effects of micromolar calcium, phorbol ester, and protein alkylating agents.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Chromaffin Granules; Chromaffin System; Digitonin; Ethylmaleimide; Exocytosis; Lipid Metabolism; Magnesium; Norepinephrine; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Response of Walker 256 carcinosarcoma cells to 12-O-tetradecanoylphorbol 13-acetate: possible regulation by endogenous cyclooxygenase metabolites.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma 256, Walker; Cell Adhesion; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Indomethacin; Neoplasm Transplantation; Phorbols; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate | 1985 |
Cyclosporin A inhibits biological effects of tumor promoting phorbol esters.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Chromatography, Thin Layer; Cyclosporins; Edema; Female; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Differential effects of thyrotropin-releasing hormone, vasoactive intestinal peptide, phorbol ester, and depolarization in GH4C1 rat pituitary cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Colforsin; Diterpenes; Drug Synergism; Electrochemistry; Growth Hormone; Phorbols; Pituitary Gland; Potassium Chloride; Prolactin; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Time Factors; Vasoactive Intestinal Peptide | 1985 |
Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells.
Topics: Antibodies, Monoclonal; Humans; Lymphocyte Activation; Phorbols; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins.
Topics: Animals; Blood; Calcimycin; Endopeptidases; Female; Fibroblasts; Heat-Shock Proteins; Leucine; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Pregnancy; Rats; Serine Endopeptidases; Tetradecanoylphorbol Acetate | 1985 |
Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.
Topics: Aminoquinolines; Animals; Calcimycin; Calcium; Diglycerides; Dose-Response Relationship, Drug; Drug Synergism; Ethers; Ionomycin; Liver; Male; Phenylephrine; Phorbols; Phosphorylases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Vasopressins | 1985 |
gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acid; Arachidonic Acids; Interferon-gamma; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Prostaglandins; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1985 |
Effects of short-term exposure to the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Retinoic acid and 12-O-tetradecanoylphorbol-13-acetate alter release of glycoproteins from mouse fibroblast BALB/C 3T6 cells.
Topics: Amino Acids; Animals; Cells, Cultured; Collagen; Fibroblasts; Glycoproteins; Mice; Mice, Inbred BALB C; Molecular Weight; Pepsin A; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
A new function for activated protein C: activated protein C prevents inhibition of plasminogen activators by releasate from mononuclear leukocytes--platelet suspensions stimulated by phorbol diester.
Topics: Blood Platelets; Fibrinolysis; Glycoproteins; Humans; In Vitro Techniques; Leukocytes; Monocytes; Phorbols; Plasminogen Activators; Plasminogen Inactivators; Protein C; Tetradecanoylphorbol Acetate; Thrombin; Urokinase-Type Plasminogen Activator | 1985 |
Retinoids antagonize the induction of ornithine decarboxylase activity by phorbol esters and phospholipase C in rat tracheal epithelial cells.
Topics: Animals; Cycloheximide; Eflornithine; Epithelial Cells; Epithelium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Phorbols; Phospholipases; Rats; Receptors, Drug; Retinoids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Trachea; Type C Phospholipases | 1985 |
Distinction between antigen receptor and IL 2 receptor triggering events in the activation of alloreactive T cell clones with calcium ionophore and phorbol ester.
Topics: Animals; Clone Cells; Drug Synergism; Ethers; Interleukin-2; Ionomycin; Ionophores; Lymphocyte Activation; Lymphokines; Macrophage-Activating Factors; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Inbred CBA; Phorbols; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Effect of serum and 12-O-tetradecanoyl-phorbol-13-acetate on FSH-stimulated conversion of 4-androstene-3,17-dione to oestrogens in cell and organ cultures of suckling mouse ovaries.
Topics: Androstenedione; Animals; Animals, Suckling; Blood; Cells, Cultured; Estrogens; Female; Follicle Stimulating Hormone; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Ovary; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Regulation of arachidonic acid metabolism in Madin-Darby canine kidney cells: stimulation of synthesis of the cyclooxygenase system by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dactinomycin; Dogs; Enzyme Induction; Kidney; Kinetics; Phorbols; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1985 |
12-O-tetradecanoylphorbol-13-acetate-induced rapid loss of persistent 7,12-dimethylbenz[a]anthracene-DNA adducts in mouse epidermis and dermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Epidermis; Female; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The stimulation by the tumour promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital of the growth of primary neonatal rat hepatocytes.
Topics: Animals; Calmodulin; Carcinogens; Cell Division; Egtazic Acid; Epidermal Growth Factor; Female; Imidazoles; In Vitro Techniques; Lanthanum; Liver; Male; Phenobarbital; Phorbols; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate | 1985 |
The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Drug Synergism; Glycerides; Growth Substances; Humans; Kidney; Liver; Lung; Peptides; Phorbols; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
Inhibition of insulin receptor binding by A23187: synergy with phorbol esters.
Topics: Calcimycin; Cell Differentiation; Cell Line; Cytoplasm; Dihydroxycholecalciferols; Drug Synergism; Humans; Insulin; Monocytes; Phorbols; Protein Binding; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1985 |
Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets.
Topics: Blood Platelets; Calcimycin; Collagen; Drug Synergism; Humans; Phorbols; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2; Thromboxanes | 1985 |
Studies on the mechanism of phorbol ester-induced inhibition of intercellular junctional communication.
Topics: Animals; Calcimycin; Cell Communication; Cells, Cultured; Chlorpromazine; Cricetinae; Cricetulus; Diglycerides; Gallic Acid; Humans; Imidazoles; Phorbols; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Suppressive activity of 12-O-tetradecanoyl phorbol-13-acetate on the induction of cytotoxic T cells in vitro.
Topics: Animals; Cells, Cultured; Female; Lymphocyte Activation; Male; Mice; Phorbols; Spleen; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced increase in vascular permeability in mouse skin by lipoxygenase inhibitors.
Topics: Animals; Benzoquinones; Capillary Permeability; Catechols; Female; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Prostaglandin-Endoperoxide Synthases; Quercetin; Quinones; Skin; Tetradecanoylphorbol Acetate | 1985 |
[Phorbol diester induces phenotypic and functional changes in human T-lymphocyte clones].
Topics: Animals; Antigens, Surface; Cell Division; Clone Cells; Fluorescent Antibody Technique; Humans; Phenotype; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Non-histone chromosomal protein acceptors for poly(ADP)-ribose in phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts (C3H10T1/2).
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromosomal Proteins, Non-Histone; Hydrogen-Ion Concentration; Mice; Molecular Weight; Nucleoside Diphosphate Sugars; Phorbols; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Tetradecanoylphorbol Acetate | 1985 |
Thyrotropin-releasing hormone and epidermal growth factor stimulate prolactin synthesis by a pathway(s) that differs from that used by phorbol esters: dissociation of actions by calcium dependency and additivity.
Topics: Animals; Calcium; Cell Line; Epidermal Growth Factor; Inositol Phosphates; Phorbols; Pituitary Gland; Prolactin; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |
Interaction of tumour promoters with epithelial cells in culture. An immunofluorescence study.
Topics: Actinin; Actins; Animals; Carcinogens; Cell Membrane; Concanavalin A; Cytoskeleton; Dogs; Epithelium; Fluorescent Antibody Technique; Kidney; Membrane Lipids; Muscle Proteins; Phorbols; Receptors, Mitogen; Tetradecanoylphorbol Acetate; Vinculin | 1985 |
Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription.
Topics: Animals; Calcium; Cells, Cultured; Epidermal Growth Factor; Gallopamil; Nifedipine; Phorbols; Phosphorylation; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1985 |
Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Diglycerides; Enzyme Activation; Fatty Acids, Unsaturated; Glycerides; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Phorbols; Phospholipases A; Phospholipases A2; Phospholipids; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1985 |
Modulation of phospholipid metabolism in murine keratinocytes by tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cells, Cultured; Eicosanoic Acids; Lipoxygenase; Membrane Lipids; Mice; Mice, Inbred BALB C; Phorbols; Phospholipids; Skin; Stearic Acids; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester-inactivation of cloned cytotoxic T lymphocytes: restoration of lytic activity by interleukin 2 and induction of interferon production are separable events.
Topics: Animals; Cell Line; Clone Cells; Cytotoxicity, Immunologic; Interferon Inducers; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1985 |
Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cells, Cultured; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Epidermis; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1985 |
TPA induces differentiation of purified human myeloblasts in the absence of proliferation.
Topics: Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Division; Colony-Stimulating Factors; DNA Replication; Eflornithine; Hematopoietic Stem Cells; Humans; Ornithine; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1985 |
The mode of action of the calcium ionophore A23187 on T cell proliferation. I. The ionophore does not replace lymphokines but acts via induction of IL-2 production on IL-2 responsive cells.
Topics: Animals; Antibodies, Monoclonal; Calcimycin; Cell Division; Drug Synergism; Female; Interleukin-2; Lectins; Mice; Mice, Inbred BALB C; Peanut Agglutinin; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1985 |
Failure of 1-oleoyl-2-acetylglycerol to mimic the cell-differentiating action of 12-O-tetradecanoylphorbol 13-acetate in HL-60 cells.
Topics: Acid Phosphatase; Animals; Brain; Calcimycin; Cell Adhesion; Cell Differentiation; Cell Line; Diglycerides; Enzyme Activation; Glycerides; Humans; Leukemia, Myeloid; Mice; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate-like mechanism.
Topics: Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Cations, Divalent; Cell Aggregation; Cytochalasin B; Diglycerides; Diterpenes; Drug Resistance; Glycerides; Humans; Neutrophils; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
Modulation of Na/H exchange by a tumor promoting phorbol ester in different fibroblast cell lines.
Topics: Calcimycin; Cell Line; Fibroblasts; Humans; Hydrogen; Ion Exchange; Male; Phorbols; Sodium; Tetradecanoylphorbol Acetate | 1985 |
Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products.
Topics: Acetophenones; Animals; Female; Glucose; Indomethacin; Liver Glycogen; Perfusion; Phorbols; Phospholipases A; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Vasopressins | 1985 |
Phorbol myristate acetate induces endocytosis as well as exocytosis and hydroosmosis in toad urinary bladder.
Topics: Animals; Bufo marinus; Dimethyl Sulfoxide; Endocytosis; Exocytosis; Female; Histocytochemistry; Microscopy, Electron; Osmosis; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder; Vasopressins | 1985 |
12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Enzyme Induction; Female; Mice; Models, Biological; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Synergistic action of A23187 and phorbol ester on human B cell activation.
Topics: B-Lymphocytes; Calcimycin; Drug Synergism; Humans; Immunoglobulins; Lymphocyte Activation; Palatine Tonsil; Phorbols; Spleen; Tetradecanoylphorbol Acetate | 1985 |
Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester.
Topics: Animals; Cells, Cultured; Chick Embryo; Fibroblasts; Growth Substances; Oncogene Protein pp60(v-src); Phorbols; Phosphorylation; Protein Kinases; Retroviridae Proteins; Ribosomal Protein S6; Ribosomal Proteins; Tetradecanoylphorbol Acetate | 1985 |
Aequorin detects increased cytoplasmic calcium in platelets stimulated with phorbol ester or diacylglycerol.
Topics: Aequorin; Aminoquinolines; Blood Platelets; Calcium; Cytoplasm; Diglycerides; Dose-Response Relationship, Drug; Egtazic Acid; Glycerides; Humans; Luminescent Proteins; Phorbols; Platelet Aggregation; Tetradecanoylphorbol Acetate | 1985 |
A combination of calcium ionophore and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates the growth of purified resting B cells.
Topics: B-Lymphocytes; Calcimycin; Cell Cycle; Dose-Response Relationship, Drug; Drug Synergism; Ethers; Humans; Ionomycin; Lymphocyte Activation; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Interleukin 2 mRNA induction in human lymphocytes: analysis of the synergistic effect of a calcium ionophore A23187 and a phorbol ester.
Topics: Calcimycin; Calcium; Calmodulin; Cells, Cultured; Drug Synergism; Gallic Acid; Gene Expression Regulation; Interleukin-2; Palatine Tonsil; Phorbols; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester induction of Ia and a shared B-cell/T-cell phenotype in normal but not autoimmune (lpr) mice.
Topics: Animals; Antigens, Surface; B-Lymphocytes; Bone Marrow Cells; Cell Separation; Drug Interactions; Flow Cytometry; Genes, MHC Class II; Histocompatibility Antigens Class II; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Phenotype; Phorbols; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Enhanced production of human interferon-gamma by the use of a combination of inducers--phytohemagglutinin, picibanil and tumor promoting agent.
Topics: Biological Products; Drug Interactions; Humans; Interferon Inducers; Interferon-gamma; Kinetics; Leukocytes; Phorbols; Phytohemagglutinins; Picibanil; Tetradecanoylphorbol Acetate | 1985 |
Lipid peroxidation products and clastogenic material in culture media of human leukocytes exposed to the tumor promoter phorbol-myristate-acetate.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromosome Aberrations; Culture Media; Dose-Response Relationship, Drug; Free Radicals; Humans; Leukocytes; Lipid Peroxides; Malondialdehyde; Oxygen; Phorbols; Tetradecanoylphorbol Acetate; Thiobarbiturates | 1985 |
Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis.
Topics: Acetone; Alkynes; Animals; Carcinogens; Cycloheximide; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Epidermis; Female; Mice; Ornithine Decarboxylase; Papilloma; Phorbols; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells.
Topics: Animals; Cell Adhesion; Diglycerides; Diterpenes; Lung Neoplasms; Male; Mice; Mitogens; Neoplasm Metastasis; Phorbol Esters; Phorbols; Protein Kinases; Structure-Activity Relationship; Terpenes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1986 |
Stimulation of parathyroid hormone secretion by phorbol esters is associated with a decrease of cytosolic calcium.
Topics: Animals; Calcium; Cattle; Cytosol; Extracellular Space; Parathyroid Glands; Parathyroid Hormone; Phorbols; Tetradecanoylphorbol Acetate | 1986 |
Altered catalytic properties of protein kinase C in phorbol ester treated cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Catalysis; Cattle; Cell Line; Chromatography, DEAE-Cellulose; Humans; Mice; Phorbols; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Substrate Specificity; Tetradecanoylphorbol Acetate | 1986 |
The effects of phorbol ester on anabolism of lipids of cultured human skin fibroblasts.
Topics: Acetates; Acetic Acid; Cells, Cultured; Cholesterol; Cholesterol Esters; Fatty Acids, Nonesterified; Fibroblasts; Galactose; Humans; Lipid Metabolism; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Increased persistence of induced mutants of Chinese hamster cells by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Culture Media; Ethyl Methanesulfonate; Female; Mutation; Ovary; Phorbols; Probability; Tetradecanoylphorbol Acetate; Thioguanine | 1986 |
The skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate induces transcription of the c-fos proto-oncogene in human bladder epithelial cells.
Topics: Cells, Cultured; Epithelium; Humans; Phorbols; Proto-Oncogene Mas; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urinary Bladder | 1986 |
Measurement of enzyme activities in mouse epidermis following phorbol ester treatment: a potential artifact.
Topics: Animals; Catalase; Epidermis; Mice; Phorbols; Research Design; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of the specific binding of 12-O-tetradecanoylphorbol-13-acetate to mouse epidermal membrane fractions by glycyrrhetic acid.
Topics: Animals; Binding Sites; Caenorhabditis elegans Proteins; Carrier Proteins; Dose-Response Relationship, Drug; Epidermis; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Membranes; Mice; Mice, Inbred ICR; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Increase in urokinase plasminogen activator mRNA synthesis in human carcinoma cells is a primary effect of the potent tumor promoter, phorbol myristate acetate.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Cycloheximide; DNA Replication; Genes; Humans; Kinetics; Phorbols; Platelet-Derived Growth Factor; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urokinase-Type Plasminogen Activator | 1986 |
Histopathologic features of phorbol myristate acetate-induced lung injury.
Topics: Acute Disease; Animals; Bronchi; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hydroxyproline; Lung; Lung Injury; Neutropenia; Organ Size; Phorbols; Pulmonary Alveoli; Pulmonary Fibrosis; Rabbits; Tetradecanoylphorbol Acetate; Therapeutic Irrigation | 1985 |
In-vitro induction of some features of hairy cell leukemia in chronic lymphocytic leukemia and immunocytoma cells.
Topics: Cell Differentiation; Humans; Leukemia, Hairy Cell; Leukemia, Lymphoid; Neoplastic Stem Cells; Phorbols; Plasmacytoma; Stem Cells; Tetradecanoylphorbol Acetate | 1985 |
Specific stimulation by phorbol esters of the phosphorylation of histones H2B and H4 in murine lymphocytes.
Topics: Animals; Cells, Cultured; Histones; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbol Esters; Phorbols; Phosphorylation; Tetradecanoylphorbol Acetate | 1985 |
Release of fibronectin is linked to tumor promotion: response of promotable and non-promotable clones of a mouse epidermal cell line.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Epidermis; Fibronectins; Mice; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Response of cultured rat liver epithelial cell lines to tumour-promoting phorbol esters.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Aggregation; Cell Division; Cell Line; Culture Media; Epithelium; Extracellular Matrix; Fibronectins; Fucose; Glycoproteins; Laminin; Liver; Membrane Glycoproteins; Membrane Proteins; Phorbols; Procollagen; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Temperature; Tetradecanoylphorbol Acetate | 1985 |
Comparison of the inhibitory effects of diverse amino acids and amino acid analogs on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in isolated epidermal cells.
Topics: Amino Acids; Animals; Cycloheximide; Enzyme Activation; Epidermis; Female; Half-Life; Hot Temperature; Mice; Ornithine Decarboxylase; Phorbols; Protein Denaturation; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Induction of 5,6-ring-saturated thymine bases in NIH-3T3 cells by phorbol ester-stimulated macrophages: role of reactive oxygen intermediates.
Topics: Animals; Catalase; Cells, Cultured; Dermatitis; DNA; Hydrogen Peroxide; Macrophages; Mice; Oxygen; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Thymine | 1985 |
Enhancement of human growth hormone-stimulated mitogenesis of Nb2 node lymphoma cells by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cattle; Cell Cycle; Drug Synergism; Fetus; Growth Hormone; Humans; Lymph Nodes; Lymphatic Diseases; Lymphoma; Mitosis; Neoplasms; Osmolar Concentration; Phorbols; Prolactin; Sheep; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages.
Topics: Animals; Exocytosis; Female; Horseradish Peroxidase; Isoquinolines; Macrophages; Mice; Mice, Inbred ICR; Peroxidases; Phorbols; Pinocytosis; Tetradecanoylphorbol Acetate | 1985 |
Oxidative properties of 12-O-tetradecanoylphorbol-13-acetate-stimulated human blood monomorphonuclear leukocytes and their toxicity against a human lung carcinoma cell line.
Topics: Cell Line; Cytotoxicity, Immunologic; Free Radicals; Glutathione; Humans; Killer Cells, Natural; Leukocytes; Lung Neoplasms; Male; Middle Aged; Oxidation-Reduction; Phorbols; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
[TPA enhancement of the mutagenic and transforming action of bovine adenovirus type 3 on cultured mouse cells].
Topics: Adenoviridae; Animals; Cattle; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Mice; Mice, Inbred C3H; Mutation; Neoplasm Transplantation; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
[Tissue polypeptide antigen in gynecological cancer].
Topics: Adenocarcinoma; Adult; Carcinoembryonic Antigen; Carcinoma, Squamous Cell; Female; Humans; Neoplasm Proteins; Ovarian Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms; Uterine Neoplasms | 1985 |
Cells from patients with ataxia telangiectasia are abnormally sensitive to the cytotoxic effect of a tumor promoter, phorbol-12-myristate-13-acetate.
Topics: Ataxia Telangiectasia; Cell Division; Cell Survival; Cells, Cultured; DNA Repair; Heterozygote; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment.
Topics: Animals; Epidermis; Female; Hyperplasia; Mast Cells; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Contrasting responses of normal and transformed rat tracheal epithelial cells to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; Phorbols; Rats; Tetradecanoylphorbol Acetate; Trachea | 1985 |
Dermal collagen metabolism during tumor promotion with 12-O-tetradecanoylphorbol-13-acetate in mouse skin.
Topics: Animals; Collagen; Female; Hydroxyproline; Methylcholanthrene; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Studies on the tumour promoter-induced release of fibronectin from human lung fibroblasts, and its counteraction by retinoic acid.
Topics: Cells, Cultured; Fibroblasts; Fibronectins; Humans; Lung; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Effects of 12-O-tetradecanoylphorbol-13-acetate and retinoids on intercellular junctional communication measured with a citrulline incorporation assay.
Topics: Animals; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Aciduria; Cell Communication; Cell Line; Cells, Cultured; Citrulline; Cricetinae; Cricetulus; Dimethyl Sulfoxide; Fibroblasts; Fluocinolone Acetonide; Intercellular Junctions; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Acute undifferentiated leukemia: induction of partial differentiation by phorbol ester.
Topics: Acute Disease; Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Rapid morphological and substratum adherence response by hairy cell and other human leukemic cells to phorbol ester tumor promoters.
Topics: Antimetabolites; Cell Adhesion; Cell Differentiation; Cell Membrane; Cells, Cultured; Humans; Leukemia; Leukemia, Hairy Cell; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds.
Topics: Animals; Cysteine; Female; Glutathione; Glutathione Peroxidase; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Selenium; Skin; Tetradecanoylphorbol Acetate | 1985 |
Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury.
Topics: Animals; Antioxidants; Catalase; Free Radicals; Hydrogen Peroxide; Kidney Glomerulus; Neutrophils; Oxygen; Phorbols; Proteinuria; Rats; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1985 |
A 12-O-tetradecanoylphorbol-13-acetate (TPA)-nonproliferative variant of 3T3 cells is resistant to TPA-enhanced gene amplification.
Topics: Animals; Cadmium; Cell Division; Cell Line; DNA; Drug Resistance; Gene Amplification; Mice; Mitosis; Mutation; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Induction of incoordinate synthesis of muscle proteins by the tumor promoter TPA and the carcinogen EMS.
Topics: Animals; Cells, Cultured; Chick Embryo; Desmin; Ethyl Methanesulfonate; Gene Expression Regulation; Isoelectric Point; Molecular Weight; Muscle Development; Muscle Proteins; Muscles; Phorbols; Tetradecanoylphorbol Acetate; Vimentin | 1985 |
A strain of hairless mouse susceptible to tumorigenesis by TPA alone: studies with 8-methoxypsoralen and solar simulated radiation.
Topics: Animals; Cocarcinogenesis; Female; Methoxsalen; Mice; Mice, Hairless; Neoplasms, Experimental; Phorbols; PUVA Therapy; Sunlight; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of intercellular communication and enhancement of morphological transformation of Syrian hamster embryo cells by TPA. Use of TPA-sensitive and TPA-resistant cell lines.
Topics: Animals; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Drug Resistance; In Vitro Techniques; Mesocricetus; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Effects of soluble stimuli on human monocyte secretion.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylglucosaminidase; Cycloheximide; Dipeptides; Gallic Acid; Humans; Monocytes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Acute effects of tumor-promoting phorbol esters on hepatic intermediary metabolism.
Topics: Animals; Fatty Acids; Food; Gluconeogenesis; Glutamine; Ketone Bodies; Liver; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Starvation; Tetradecanoylphorbol Acetate | 1985 |
Normal and transformed human prokeratinocytes express divergent effects of a tumor promoter on cell cycle-mediated control of proliferation and differentiation.
Topics: Adult; Carcinoma, Squamous Cell; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Humans; Infant, Newborn; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1985 |
A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.
Topics: Aequorin; Animals; Blood Physiological Phenomena; Calcium; Culture Media; Cytosol; Fibroblasts; Growth Substances; Interphase; Mice; Mitosis; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Indirect induction of a clastogenic effect in epidermal cells by a tumor promoter.
Topics: Animals; Catalase; Cells, Cultured; DNA; DNA Repair; Dose-Response Relationship, Drug; Epidermis; Mice; Mutagens; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
The effect of some experimental parameters on the inhibition of metabolic cooperation by phorbol myristate acetate.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Communication; Cell Count; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fibroblasts; Hypoxanthine Phosphoribosyltransferase; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Time Factors; Tritium | 1985 |
Mechanistic aspects of the delay in the G2 phase of the cell cycle caused by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; beta-Aminoethyl Isothiourea; Cell Cycle; Cycloheximide; HeLa Cells; Humans; Mitosis; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts.
Topics: Animals; Antioxidants; Cells, Cultured; DNA; Fibroblasts; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Nucleoside Diphosphate Sugars; Oxygen; Phorbols; Poly Adenosine Diphosphate Ribose; Tetradecanoylphorbol Acetate | 1985 |
Collagen expression in embryonic chicken chondrocytes treated with phorbol myristate acetate.
Topics: Animals; Cartilage; Cell Differentiation; Cell Division; Chick Embryo; Collagen; Gene Expression Regulation; Phorbols; Procollagen; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcriptional Activation | 1985 |
Altered beta-actin gene expression in phorbol myristate acetate-treated chondrocytes and fibroblasts.
Topics: Actins; Animals; Cartilage; Cell Adhesion; Cells, Cultured; Chick Embryo; Fibroblasts; Gene Expression Regulation; Muscles; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate | 1985 |
12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Endothelium; Liver; Methylazoxymethanol Acetate; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1985 |
12-O-Tetradecanoyl-phorbol-13-acetate (TPA) induced congenital kidney defects and embryomortality in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Kidney; Mice; Mice, Inbred Strains; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate | 1985 |
Reactive oxygen dependent activation of polycyclic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes.
Topics: Benzopyrenes; Biotransformation; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; Humans; Luminescent Measurements; Lung Neoplasms; Mutagenicity Tests; Neutrophils; Oxidation-Reduction; Oxygen; Phorbols; Polycyclic Compounds; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1985 |
Induction of fibrinolytic activity in HeLa cells by phorbol myristate acetate. Tissue-type plasminogen activator antigen and mRNA augmentation require intermediate protein biosynthesis.
Topics: Antigens; Cycloheximide; Fibrinolysis; HeLa Cells; Humans; Oncogenes; Phorbols; Plasminogen Activators; Protein Biosynthesis; RNA, Messenger; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter-stimulated translocation of glucose transport system in mouse embryo fibroblast Swiss 3T3 cell.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cells, Cultured; Cytochalasin B; Embryo, Mammalian; Fibroblasts; Glucose; Mice; Microsomes; Monosaccharide Transport Proteins; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
In vivo induction of rat hepatic ornithine decarboxylase and plasminogen activator by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Cycloheximide; Dactinomycin; Enzyme Induction; Liver; Ornithine Decarboxylase; Phorbols; Plasminogen Activators; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of hCG-stimulated adenylate cyclase in purified mouse Leydig cells by the phorbol ester PMA.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Diterpenes; Guanylyl Imidodiphosphate; Leydig Cells; Male; Mice; Phorbols; Testosterone; Tetradecanoylphorbol Acetate | 1985 |
Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of the hormone-sensitive inhibitory pathway.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Blood Platelets; Catalysis; Colforsin; Diterpenes; Enzyme Activation; Epinephrine; Guanosine Triphosphate; Humans; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate; Thrombin | 1985 |
The toxic response of preneoplastic rat tracheal epithelial cells to 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Male; Phorbols; Rats; Tetradecanoylphorbol Acetate; Trachea | 1985 |
The conditions for the modification of radiation transformation in vitro by a tumor promoter and protease inhibitors.
Topics: Animals; Antipain; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Mice; Oligopeptides; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; X-Rays | 1985 |
Tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced chromosome aberrations in mouse keratinocyte cell lines: a possible genetic mechanism of tumor promotion.
Topics: Animals; Cell Line; Chromosome Aberrations; Cocarcinogenesis; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Gene Amplification; Karyotyping; Mice; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Muscarinic receptor-mediated increase in cytoplasmic free Ca2+ in isolated bovine adrenal medullary cells. Effects of TMB-8 and phorbol ester TPA.
Topics: Acetylcholine; Adrenal Medulla; Aminoquinolines; Animals; Calcium; Calcium Channel Blockers; Cattle; Cytosol; Enzyme Activation; Fluorescent Dyes; Gallic Acid; In Vitro Techniques; Phorbols; Protein Kinase C; Receptors, Muscarinic; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1985 |
Phorbol myristate acetate causes in guinea-pig lung parenchymal strip a maintained spasm which is relatively resistant to isoprenaline.
Topics: Aminophylline; Animals; Colforsin; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Lung; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Phorbol myristate acetate (PMA) suppresses polarization and locomotion and alters F-actin content of Walker carcinosarcoma cells.
Topics: Actin Cytoskeleton; Actins; Amanitins; Animals; Carcinoma 256, Walker; Cell Adhesion; Cell Movement; Colchicine; Cytoskeleton; Microtubules; Peptides, Cyclic; Phorbols; Rats; Tetradecanoylphorbol Acetate; Vinblastine | 1985 |
Phorbol myristate acetate receptors in human polymorphonuclear neutrophils.
Topics: Binding Sites; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cytoplasmic Granules; Cytosol; Humans; Neutrophils; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1985 |
Comparison of differentiation patterns in 12-O-tetradecanoylphorbol-13-acetate-treated epidermis and fetal epidermis.
Topics: Animals; Cell Differentiation; Epidermal Cells; Mice; Microscopy, Electron; Phorbols; Skin; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1985 |
Phospholipase C mimics tumor promoter-induced chemiluminescence in murine epidermal cells.
Topics: Animals; Epidermis; In Vitro Techniques; Kinetics; Luminescent Measurements; Mice; Oxidation-Reduction; Phorbols; Phospholipases; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Lymphoid colony growth with phorbol myristate acetate and lymphocyte-conditioned media in chronic lymphocytic leukemia and malignant lymphomas.
Topics: Cell Division; Cells, Cultured; Chronic Disease; Culture Media; Humans; Leukemia, Lymphoid; Lymph Nodes; Lymphocytes; Lymphoma; Phorbols; Phytohemagglutinins; Prognosis; Tetradecanoylphorbol Acetate | 1985 |
Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Indomethacin; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase Inhibitors; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
An examination of the DNA damaging and repair inhibitory capacity of phorbol myristate acetate in human diploid fibroblasts.
Topics: Cells, Cultured; DNA; DNA Repair; Fibroblasts; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Specific stimulation of histone H2B and H4 phosphorylation in mouse lymphocytes by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Cell Division; Cells, Cultured; Histones; Kinetics; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbols; Phosphoproteins; Phosphorylation; Pokeweed Mitogens; Spleen; Tetradecanoylphorbol Acetate | 1985 |
Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation.
Topics: Blood Platelets; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Humans; Isoelectric Point; Microscopy, Electron, Scanning; Molecular Weight; Phorbol Esters; Phorbols; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tropomyosin | 1985 |
Poly ADP-ribosylation of histones in tumor promoter phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts C3H10T1/2.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromosomal Proteins, Non-Histone; Embryo, Mammalian; Fibroblasts; Histones; Mice; Mice, Inbred C3H; Nucleoside Diphosphate Sugars; Phorbols; Poly Adenosine Diphosphate Ribose; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate | 1985 |
Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis.
Topics: Calcium; Chemotaxis, Leukocyte; Cytoplasm; Cytoplasmic Granules; Glucuronidase; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester-induced alteration of differentiation and proliferation in human hematopoietic tumor cell lines: relationship to the presence and subcellular distribution of protein kinase C.
Topics: Biological Transport; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Compartmentation; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Erythropoiesis; Hematopoietic Stem Cells; Humans; Neoplastic Stem Cells; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1985 |
Phorbol ester induced 1,2-diacylglycerol accumulation and protein phosphorylation in C3H/10T1/2 mouse embryo cells.
Topics: Animals; Autoradiography; Cells, Cultured; Diglycerides; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Glycerides; Glycerol; Kinetics; Mice; Mice, Inbred C3H; Molecular Weight; Phorbols; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Proteins; Tetradecanoylphorbol Acetate; Tritium | 1985 |
Induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol 13-acetate in hamster fibroblasts. Relationship between levels of enzyme activity, immunoreactive protein, and RNA during the induction process.
Topics: Animals; Cell Line; Cricetinae; Cycloheximide; Enzyme Induction; Fibroblasts; Immune Sera; Kinetics; Nucleic Acid Hybridization; Ornithine Decarboxylase; Phorbols; Protein Biosynthesis; Radioimmunoassay; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Evidence that phorbol ester interferes with stimulated Ca2+ redistribution by activating Ca2+ efflux in neutrophil leucocytes.
Topics: Aminoquinolines; Animals; Calcium; Concanavalin A; Fluorescent Dyes; In Vitro Techniques; Neutrophils; Phorbols; Swine; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting phorbol diester mimics two distinct neuronotrophic factors.
Topics: Animals; Cells, Cultured; Chick Embryo; Ciliary Neurotrophic Factor; Ganglia, Parasympathetic; Ganglia, Spinal; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1985 |
Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Enzyme Induction; Epidermis; Female; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Mice; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol ester activation of epidermal protein kinase C from tumor promotion sensitive and resistant mouse strains.
Topics: Animals; Calcium; Chromatography, DEAE-Cellulose; Cytosol; Drug Resistance; Enzyme Activation; Epidermis; Female; Mice; Mice, Inbred C57BL; Phorbols; Protein Kinase C; Skin; Species Specificity; Tetradecanoylphorbol Acetate | 1985 |
Effect of interferon on chemiluminescence and hydroxyl radical production in murine macrophages stimulated by PMA.
Topics: Animals; Azides; Catalase; Catechols; Dose-Response Relationship, Drug; Female; Hydrogen Peroxide; Interferon Type I; Luminescent Measurements; Macrophages; Masoprocol; Mice; Mice, Inbred C57BL; Oxygen Consumption; Phorbols; Sodium Azide; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors; Zymosan | 1985 |
The effects of phorbol ester, diacylglycerol, phospholipase C and Ca2+ ionophore on protein phosphorylation in human and sheep erythrocytes.
Topics: Animals; Blood Proteins; Calcium; Diglycerides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Glycerides; Humans; In Vitro Techniques; Ionophores; Peptide Fragments; Phorbols; Phosphates; Phosphorylation; Sheep; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Neurite-promoting effects of 12-O-tetradecanoylphorbol-13-acetate on chick embryo neurons.
Topics: Animals; Axons; Cell Differentiation; Cell Survival; Cells, Cultured; Chick Embryo; Ganglia, Parasympathetic; Ganglia, Sympathetic; Nerve Regeneration; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
The role of C-kinase in the physiological activation of the neutrophil oxidase. Evidence from using pharmacological manipulation of C-kinase activity in intact cells.
Topics: Animals; Diglycerides; Diterpenes; Enzyme Activation; In Vitro Techniques; Latex; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; Neutrophils; Phorbols; Protein Kinase C; Rats; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
Treatment with phorbol esters leads to spermine depletion and inhibition of DNA synthesis in phytohemagglutinin-activated bovine lymphocytes.
Topics: Acetyltransferases; Animals; Cattle; Cells, Cultured; Depression, Chemical; DNA Replication; Lymphocyte Activation; Lymphocytes; Ornithine Decarboxylase; Phorbols; Phytohemagglutinins; Putrescine; Spermine; Tetradecanoylphorbol Acetate | 1985 |
Involvement of histamine in vascular permeability increase of the rat pleurisy induced by phorbol myristate acetate.
Topics: Animals; Capillary Permeability; Cimetidine; Croton Oil; Drug Interactions; Histamine; Histamine Antagonists; Leukocytes; Male; Methysergide; Phorbols; Pleurisy; Pyrilamine; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Stimulation of macrophage activity by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Glucosamine; Glucose; Hexosephosphates; Lymphoma; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; Pinocytosis; Prostaglandins; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1984 |
Effects of chemical inducers on the Epstein-Barr virus cycle in epithelial/nasopharyngeal carcinoma hybrid cell line.
Topics: Butyrates; Cell Line; Herpesvirus 4, Human; Humans; Hydrogen Peroxide; Nasopharyngeal Neoplasms; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.
Topics: Adenylyl Cyclases; Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Phorbols; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors; Turkeys | 1984 |
Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore.
Topics: Animals; Calcimycin; Calcium; Drug Synergism; Guinea Pigs; Kinetics; Magnesium; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Regulation of phosphatidylcholine synthesis and the activity of CTP-cholinephosphate cytidylytransferase in myoblasts by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Choline-Phosphate Cytidylyltransferase; Cytidine Triphosphate; Enzyme Activation; Muscles; Nucleotidyltransferases; Phorbols; Phosphates; Phosphatidylcholines; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 1984 |
Tumor promoter phorbol 12-myristate 13-acetate inhibits mitogen-stimulated Na+/H+ exchange in human epidermoid carcinoma A431 cells.
Topics: Carcinoma, Squamous Cell; Carrier Proteins; Cell Line; Culture Media; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Mannitol; Mitogens; Phorbols; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1984 |
Inhibition of transferring binding and iron uptake of hematopoietic cell lines by phorbol esters.
Topics: Biological Transport; Cell Division; Cell Line; Hematopoietic Stem Cells; Humans; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Phorbol Esters; Phorbols; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1984 |
Effects of n-butyrate and phorbol ester (TPA) on induction of Epstein-Barr virus antigens and cell differentiation.
Topics: Antigens, Viral; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Cells, Cultured; Herpesvirus 4, Human; Humans; Lymphocytes; Microscopy, Electron; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Stimulation of hepatic glycogenolysis by 12-O-tetradecanoylphorbol-13-acetate (TPA) via a calcium requiring process.
Topics: Animals; Calcimycin; Calcium Chloride; Cyclic AMP; Cyclic GMP; Diltiazem; Glucose; Kinetics; Liver; Liver Glycogen; Male; Phorbols; Proteins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trifluoperazine; Verapamil | 1984 |
Phorbol esters stimulate phosphatidylcholine biosynthesis by translocation of CTP:phosphocholine cytidylyltransferase from cytosol to microsomes.
Topics: Biological Transport; Choline; Choline-Phosphate Cytidylyltransferase; Cytosol; Digitonin; HeLa Cells; Humans; Kinetics; Microsomes; Nucleotidyltransferases; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1984 |
Synergism between phorbol ester and A23187 in superoxide production by neutrophils.
Topics: Calcimycin; Drug Synergism; Humans; Kinetics; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Effect of the phorbol ester TPA on PTH secretion. Evidence for a role for protein kinase C in the control of PTH release.
Topics: Animals; Calcium; Cattle; Cyclic AMP; Cytosol; In Vitro Techniques; Kinetics; Parathyroid Glands; Parathyroid Hormone; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester-induced threonine phosphorylation of the human epidermal growth factor receptor occurs within the EGF binding domain.
Topics: Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Models, Biological; Neoplasms; Peptide Fragments; Phorbols; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Trypsin | 1984 |
Synergistic stimulation of prolactin release by phorbol ester, A23187 and forskolin.
Topics: Animals; Calcimycin; Calcium; Cell Line; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Phorbols; Pituitary Neoplasms; Prolactin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Time Factors | 1984 |
Effect of phorbol esters on iron uptake in human hematopoietic cell lines.
Topics: Biological Transport; Calcifediol; Calcitriol; Cell Line; Dimethyl Sulfoxide; Heme; Humans; Iron; Iron Radioisotopes; Kinetics; Leukemia, Myeloid, Acute; Phorbol Esters; Phorbols; Receptors, Cell Surface; Receptors, Transferrin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transferrin; Tretinoin | 1984 |
Inhibition of cell communication between Balb/c 3T3 cells by tumor promoters and protection by cAMP.
Topics: Animals; Bucladesine; Caenorhabditis elegans Proteins; Caffeine; Carcinogens; Carrier Proteins; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Cyclic AMP; Fluorescent Dyes; Isoquinolines; Lung; Mice; Mice, Inbred BALB C; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1984 |
Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen.
Topics: Antigens, Surface; Binding Sites, Antibody; Drug Synergism; Growth Inhibitors; Humans; Interleukin-1; Isoantigens; Kinetics; Lymphocyte Activation; Phorbols; Phospholipases; Phytohemagglutinins; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7; Type C Phospholipases | 1984 |
Mouse mammary tumor virus-related sequences in mouse lymphocytes are inducible by 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Gene Expression Regulation; Genes, Viral; Lymphocytes; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred Strains; Phorbols; RNA, Messenger; Spleen; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Ecto-5'-nucleotidase. II. Effect of 12-O-tetradecanoylphorbol 13-acetate on the expression of enzyme in normal and neoplastic B-cell lines.
Topics: 5'-Nucleotidase; B-Lymphocytes; Burkitt Lymphoma; Cell Division; Cell Line; Humans; Immunoglobulin G; Lymphoma; Nucleotidases; Phenotype; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6.
Topics: Animals; Avian Sarcoma Viruses; Cell Cycle; Cell Transformation, Viral; Cells, Cultured; Chickens; Dose-Response Relationship, Drug; Gene Expression Regulation; Growth Substances; Oncogenes; Phorbols; Phosphoproteins; Phosphorylation; Ribosomal Proteins; Tetradecanoylphorbol Acetate | 1984 |
Differentiation of chronic lymphocytic leukemia cells after in vitro treatment with Epstein-Barr virus or phorbol ester. I. Immunologic and morphologic studies.
Topics: Aged; Antibody-Producing Cells; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytoplasm; Female; Herpesvirus 4, Human; Humans; Immunoglobulins; Leukemia, Lymphoid; Lymphocyte Activation; Male; Middle Aged; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Stimulation of hexose uptake in rat thymic lymphocytes by phorbol ester. A role for Ca2+ and Na+/H+ exchange?
Topics: Animals; Biological Transport, Active; Calcium; Calcium-Transporting ATPases; Carrier Proteins; Deoxy Sugars; Deoxyglucose; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Lymphocytes; Phorbols; Rats; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thymus Gland | 1984 |
Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human platelets.
Topics: Blood Platelets; Humans; Kinetics; Phorbols; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Ultrastructural studies on human lymphoblastoid cells treated with n-butyrate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Antigens, Viral; Butyrates; Butyric Acid; Cell Division; Cell Line; Herpesvirus 4, Human; Humans; Lymphocytes; Microscopy, Electron; Microscopy, Electron, Scanning; Microscopy, Phase-Contrast; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Phorbol myristate acetate-induced modulation of antibody-dependent cellular cytotoxicity by human polymorphonuclear leukocytes.
Topics: Antibody-Dependent Cell Cytotoxicity; Catalase; Humans; Hydrogen Peroxide; Neutrophils; Phorbols; Receptors, Fc; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Association of leukotriene B4 with the cytoskeleton of rabbit neutrophils. Effect of chemotactic factor and phorbol esters.
Topics: Animals; Cytoskeleton; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol Esters; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1984 |
Induction of EBV DNA demethylation and of EBV-specific transcription in Daudi cells treated with TPA and n-butyrate.
Topics: Burkitt Lymphoma; Butyrates; Butyric Acid; Cell Line; DNA Restriction Enzymes; DNA, Viral; Herpesvirus 4, Human; Humans; Methylation; Phorbols; Tetradecanoylphorbol Acetate; Transcription, Genetic; Virus Activation | 1984 |
Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Animals; Cytoplasmic Granules; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Insulin; Insulinoma; Membrane Proteins; Pancreatic Neoplasms; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester-induced contraction of arterial smooth muscle and inhibition of alpha-adrenergic response.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbols; Rabbits; Rats; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate | 1984 |
Studies on the molecular composition and degradation of type IV procollagen.
Topics: Cells, Cultured; Enzyme Induction; Humans; Microbial Collagenase; Peptide Fragments; Phorbols; Procollagen; Substrate Specificity; Tetradecanoylphorbol Acetate; Trypsin | 1984 |
Shope fibroma virus. III: Stimulation of the growth of the noncytocidal strain by a tumor promoter.
Topics: Animals; Cells, Cultured; Cornea; DNA Replication; Fibroblasts; Fibroma Virus, Rabbit; Phorbols; Poxviridae; Rabbits; Tetradecanoylphorbol Acetate | 1983 |
The tumorigenic and carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of BALB/cA mice.
Topics: Animals; Carcinogens; Female; Male; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Phorbol ester tumor promoters induce epidermal transglutaminase activity.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Induction; gamma-Glutamyltransferase; Kinetics; Mice; Mice, Inbred BALB C; Phorbol Esters; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1980 |
Decreased beta-adrenergic responsiveness in mouse epidermal papillomas during tumor promotion with phorbol myristate acetate.
Topics: Adrenergic beta-Agonists; Animals; Cyclic AMP; Female; Isoproterenol; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Modulation of globin gene expression by a tumor promoter during induced differentiation of Friend erythroleukemic cells.
Topics: Animals; Cell Line; Clone Cells; Dimethyl Sulfoxide; Globins; Leukemia, Experimental; Mice; Phorbols; Plants; Poly A; Protein Biosynthesis; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Triticum | 1981 |
Phorbol myristate acetate (PMA) fails to prevent the appearance of markers associated with muscle and liver differentiation in culture.
Topics: Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Chick Embryo; Creatine Kinase; Liver; Muscles; Phorbols; Rats; Tetradecanoylphorbol Acetate; Tyrosine Transaminase | 1981 |
Inhibition by epidermal extracts of the 12-O-tetradecanoylphorbol-13-acetate induced peak of ornithine decarboxylase activity in the mouse epidermis.
Topics: Animals; Carboxy-Lyases; Enzyme Induction; Epidermis; Growth Inhibitors; Mice; Mice, Hairless; Muscles; Myocardium; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Tissue Extracts | 1981 |
Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase.
Topics: Guanylate Cyclase; Humans; In Vitro Techniques; Kinetics; Lymphocytes; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Agonist- and mitogen-induced desensitization of isoproterenol-stimulated cyclic AMP formation in mouse epidermis in vivo.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcimycin; Catecholamines; Cyclic AMP; Epidermis; Female; Isoproterenol; Mice; Mitogens; Phorbol Esters; Phorbols; Phosphoric Diester Hydrolases; Tetradecanoylphorbol Acetate | 1981 |
Effects of 12-O-tetradecanoyl phorbol-13-acetate and epidermal growth factor on the proliferation of human mutant fibroblasts in vitro.
Topics: Cell Division; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Humans; Multiple Endocrine Neoplasia; Mutation; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Inhibition of histamine-induced acid secretion in rat isolated gastric mucosa by esters of phorbol and 12-deoxyphorbol.
Topics: Animals; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; In Vitro Techniques; Male; Phorbol Esters; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1981 |
Chemical carcinogenesis by the two-stage protocol in the skin Mastomys natalensis (Muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Keratoacanthoma; Male; Muridae; Neoplasms, Experimental; Phorbols; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Biological responsiveness to the phorbol esters and specific binding of [3H]phorbol 12,13-dibutyrate in the nematode Caenorhabditis elegans, a manipulable genetic system.
Topics: Animals; Caenorhabditis; Carcinogens; Movement; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Animals, Newborn; Calcium; Cells, Cultured; Enzyme Induction; gamma-Glutamyltransferase; Kinetics; Mice; Mice, Inbred BALB C; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1982 |
Modulation of peptide binding to specific receptors on rat pituitary cells by tumor-promoting phorbol esters: decreased binding of thyrotropin-releasing hormone and somatostatin as well as epidermal growth factor.
Topics: Animals; Cell Line; Cell Membrane; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Kinetics; Phorbols; Pituitary Gland; Rats; Receptors, Cell Surface; Receptors, Somatostatin; Receptors, Thyrotropin-Releasing Hormone; Somatostatin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1982 |
Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase and reduction of adenylate cyclase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Adult; Calcium; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Cell population kinetics in hairless mouse epidermis following a single topical application of 12-O-tetradecanoylphorbol-13-acetate II.
Topics: Animals; Cell Division; DNA; Epidermal Cells; Epidermis; Female; Hyperplasia; Interphase; Kinetics; Male; Mice; Mice, Nude; Mitosis; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of epidermal transglutaminase activity by protease inhibitors.
Topics: Acyltransferases; Animals; Borohydrides; Enzyme Induction; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Oligopeptides; Phorbols; Protease Inhibitors; Skin; Tetradecanoylphorbol Acetate; Transglutaminases | 1983 |
Enhancement by TPA of phenotypes associated with transformation in carcinogen-treated human cells: evidence for a selective mechanism.
Topics: Cell Aggregation; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Culture Media; Female; gamma-Glutamyltransferase; Humans; Methylnitronitrosoguanidine; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Uterus | 1983 |
Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters.
Topics: Acyltransferases; Animals; Animals, Newborn; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Induction; Kinetics; Mice; Mice, Inbred BALB C; Phorbols; Protein Biosynthesis; Retinoids; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transglutaminases; Tretinoin | 1983 |
Effects of insulin, dexamethasone and phorbol ester on virus production in cultivated DBA/2 mouse leukemia (MLA) cells.
Topics: Animals; Cell Line; Dexamethasone; Insulin; Leukemia, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred DBA; Phorbols; Tetradecanoylphorbol Acetate; Virus Activation | 1983 |
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
Topics: Adenosine Triphosphatases; Amiloride; Animals; B-Lymphocytes; Carrier Proteins; Cation Transport Proteins; Cell Differentiation; Hydrogen-Ion Concentration; Lipopolysaccharides; Mice; Phorbols; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Fusion of intracellular membrane pools with cell surfaces of macrophages stimulated by phorbol esters and calcium ionophores.
Topics: Animals; Calcimycin; Cell Membrane; Endosomes; Intracellular Membranes; Macrophages; Phorbols; Rabbits; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1984 |
Effects of exogenous putrescine on the retinoic acid-induced reduction of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated putrescine accumulation and rate of DNA synthesis in the hairless mouse epidermis.
Topics: Animals; DNA; Epidermis; Female; Mice; Mice, Hairless; Phorbols; Putrescine; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Inhibitory effects of various drugs on phorbol myristate acetate and n-formyl methionyl leucyl phenylalanine induced O2- production in polymorphonuclear leukocytes.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of induced differentiation of C3H/10T 1/2 clone 8 mouse embryo cells by tumor promoters.
Topics: Animals; Antipain; Azacitidine; Cell Differentiation; Clone Cells; Embryo, Mammalian; Epidermal Growth Factor; Mice; Muscles; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Inhibition of adipose conversion of BALB/c 3T3 cells by interferon and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Insulin; Interferons; Lipid Metabolism; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Enhancement by 3-isobutyl-1-methylxanthine and cholera toxin of 12-O-tetradecanoylphorbol-13-acetate-stimulated cyclic nucleotide levels and ornithine decarboxylase activity in isolated epidermal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cell Separation; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic GMP; Epidermis; Mice; Nucleotides, Cyclic; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1980 |
Prevention of phorbol ester-induced catecholamine refractoriness by inhibitors of protein and RNA biosynthesis in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Cycloheximide; Female; Fluorides; Isoproterenol; Kinetics; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline | 1980 |
Enhancement of viral gene expression in Friend erythroleukemic cells by 12-O tetradecanoylphorbol-13-acetate.
Topics: Cell Differentiation; Clone Cells; Dimethyl Sulfoxide; Friend murine leukemia virus; Genes, Viral; Leukemia, Erythroblastic, Acute; Neoplasms, Experimental; Phorbols; Plasminogen Activators; RNA-Directed DNA Polymerase; RNA, Viral; Tetradecanoylphorbol Acetate | 1980 |
Release of histamine from human leukocytes stimulated with the tumor-promoting phorbol diesters. I. Characterization of the response.
Topics: Antibodies, Anti-Idiotypic; Calcium; Colchicine; Cyclic AMP; Deoxyglucose; Histamine Release; Humans; Immunoglobulin E; Leukocytes; Neoplasms; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Tumour-promoting phorbol esters inhibit DNA synthesis and enhance virus-induced interferon production in a human lymphoma cell line.
Topics: Burkitt Lymphoma; Butyrates; Cell Line; DNA; Humans; Interferons; Lymphoma; Melitten; Parainfluenza Virus 1, Human; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Suppression of lactation by tumor promoters in mice.
Topics: Animals; DNA; Female; Lactation; Mammary Glands, Animal; Mice; Phorbols; Pregnancy; RNA; Tetradecanoylphorbol Acetate | 1980 |
Natural killer cell reactivity: regulatory interactions and among phorbol ester, interferon, cholera toxin, and retinoic acid.
Topics: Animals; Cattle; Cholera Toxin; Humans; Interferons; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Nude; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Tumour-promoting compound (TPA) enhances interferon production in chronic lymphatic leukaemia cells.
Topics: Cells, Cultured; Humans; Interferon Inducers; Interferons; Leukemia, Lymphoid; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency.
Topics: Animals; Carcinogens; Diterpenes; Epidermal Cells; Epidermis; Keratins; Mice; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1980 |
Effect of tumor promote phorbol esters on the in vitro keratinization of rat epidermal cells in normal, premalignant and malignant stages.
Topics: Aneuploidy; Animals; Cell Differentiation; Cell Division; Cell Line; Diploidy; Embryo, Mammalian; Epidermal Cells; Epidermis; Keratins; Phorbol Esters; Phorbols; Precancerous Conditions; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1981 |
Effects of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate on newly synthesized proteins in mouse epidermis.
Topics: Animals; Diterpenes; Electrophoresis, Polyacrylamide Gel; Epidermis; Fluocinolone Acetonide; Hyperplasia; Keratins; Mice; Molecular Weight; Phorbol Esters; Phorbols; Protein Biosynthesis; Proteins; Terpenes; Tetradecanoylphorbol Acetate | 1981 |
Stimulation of human gamma interferon production by diterpene esters.
Topics: Cell Separation; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Interferons; Leukocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1981 |
Effect of 12-O-tetradecanoyl-phorbol-13-acetate on Ca2+ efflux and protein discharge in pancreatic acini.
Topics: Amylases; Animals; Calcimycin; Calcium; Carbachol; Ceruletide; Cyclic AMP; Cyclic GMP; Female; Guinea Pigs; Kinetics; Pancreas; Phorbols; Proteins; Tetradecanoylphorbol Acetate | 1981 |
Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Genes; Molecular Weight; Peptide Biosynthesis; Phorbols; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1981 |
Release of histamine from human leukocytes stimulated with the tumor-promoting phorbol diesters. II. Interaction with other stimuli.
Topics: Antibodies, Anti-Idiotypic; Calcimycin; Calcium; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Histamine Release; Humans; Immunoglobulin E; Kinetics; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis.
Topics: Cell Differentiation; Cells, Cultured; DNA Replication; Fluorescent Antibody Technique; Humans; Keratins; Kinetics; Microscopy, Electron; Phorbols; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Prevention of interferon-induced augmentation of cellular antitumor effector mechanisms by phorbol esters.
Topics: Animals; Interferons; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred Strains; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Virus Replication | 1982 |
Histological, proliferative, and biochemical alterations in dorsal epidermis of the Syrian golden hamster induced by 12-O-tetradecanoylphorbol-13-acetate and the calcium ionophore A 23187.
Topics: Adaptation, Physiological; Administration, Topical; Animals; Anti-Bacterial Agents; Calcimycin; Cell Division; Cricetinae; Drug Resistance; Hyperplasia; Keratins; Male; Mesocricetus; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Phorbol esters stimulate protease production by human endothelial cells.
Topics: Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Endothelium; Enzyme Activation; Humans; Kinetics; Microbial Collagenase; Phorbols; Plasminogen Activators; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1982 |
Modulation of natural killer sensitivity of murine trophoblast cells by tumor promoter and interferon.
Topics: Animals; Cell Line; Cells, Cultured; Cycloheximide; Cytotoxicity, Immunologic; Female; Indomethacin; Interferons; Killer Cells, Natural; Mice; Mice, Inbred Strains; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate; Trophoblasts | 1982 |
Diverse effects: augmentation, inhibition, and non-efficacy of 12-O-tetradecanoylphorbol-13-acetate (TPA) on retrovirus genome expression in vivo and in vitro.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cocarcinogenesis; Female; Friend murine leukemia virus; Genes, Viral; Leukemia, Experimental; Mice; Mice, Inbred Strains; Phorbols; Rats; RNA-Directed DNA Polymerase; Sarcoma Virus, Woolly Monkey; Simian virus 40; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Virus Activation | 1982 |
Phorbol ester tumor promoter modulation of alloantigen-specific T lymphocyte responses.
Topics: Cell Separation; Cell Transformation, Neoplastic; Cytotoxicity, Immunologic; Epitopes; Flow Cytometry; HLA Antigens; Humans; Interferon Inducers; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
The effects of tumour promoters on the multiplication and morphology of cultured human epidermal keratinocytes.
Topics: Animals; Cell Count; Cell Differentiation; Cell Division; Cells, Cultured; Cytological Techniques; Diterpenes; Humans; Keratins; Mice; Microscopy, Electron; Phorbol Esters; Phorbols; Skin; Terpenes; Tetradecanoylphorbol Acetate; Time Factors; Trypan Blue | 1982 |
Protein modifications induced in mouse epidermis by potent and weak tumor-promoting hyperplasiogenic agents.
Topics: Amino Acids; Animals; Female; Hyperplasia; Keratins; Mice; Mice, Inbred Strains; Peptide Fragments; Phorbols; Proteins; Skin; Tetradecanoylphorbol Acetate | 1982 |
Phorbol ester-induced differentiation of human T-lymphoblastic cell line HPB-ALL.
Topics: Antigens, Surface; Cell Differentiation; Cell Division; Cell Line; DNA; DNA Nucleotidylexotransferase; Humans; Leukemia, Lymphoid; Male; Phorbols; RNA; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Regulation of hexose transport in BALB/c 3T3 preadipose cells: effects of glucose concentration and 12-O-tetradecanoylphorbol-13-acetate.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Cell Line; Deoxy Sugars; Deoxyglucose; Fructose; Glucosamine; Glucose; Insulin; Kinetics; Mannose; Methylglucosides; Methylglycosides; Mice; Phorbols; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate | 1982 |
Biological mechanisms of phorbol myristate acetate-induced inhibition of proadipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Cell Differentiation; Interphase; Mice; Mice, Inbred BALB C; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
The effect of 12-O-tetradecanoylphorbol-13-acetate on hormone-induced differentiation of rat parotid gland in organ culture.
Topics: Amylases; Animals; Cell Differentiation; Immunochemistry; Insulin; Organ Culture Techniques; Parotid Gland; Phorbols; Prednisolone; Rats; Tetradecanoylphorbol Acetate; Thyroxine; Time Factors | 1982 |
Inhibition of interferon production in human fibroblasts by a tumor promoting phorbol ester.
Topics: Cell Line; Fibroblasts; Humans; Interferon Type I; Kinetics; Newcastle disease virus; Peptide Hydrolases; Phorbols; Poly I-C; Protein Biosynthesis; RNA; RNA, Double-Stranded; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Effects of inhibitors of tumor promotion on 12-O-tetradecanoylphorbol-13-acetate-induced keratin modification in mouse epidermis.
Topics: Animals; Carcinogens; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Epidermis; Female; Fluocinolone Acetonide; Hyperplasia; Keratins; Mice; Molecular Weight; Phorbols; Skin; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1982 |
The difference between the effects of single and double applications of 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter, on polyamine metabolism and nucleic acid synthesis in mouse epidermis.
Topics: Animals; DNA; Drug Administration Schedule; Female; Mice; Phorbols; Polyamines; Putrescine; RNA; Skin; Spermidine; Tetradecanoylphorbol Acetate | 1983 |
Growth-dependent AIB and meAIB uptake in LLC-PK1 cells: effects of differentiation inducers and of TPA.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cell Division; Cell Line; Kidney; Membrane Potentials; Ouabain; Phorbols; Protein Biosynthesis; RNA; Sodium; Swine; Tetradecanoylphorbol Acetate; Theophylline | 1983 |
Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Bleomycin; Carcinogens; Catalase; Cell Transformation, Neoplastic; Cricetinae; Embryo, Nonmammalian; Female; Free Radicals; Mesocricetus; Phorbols; Pregnancy; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1983 |
The role of calcium in macrophage chemotaxis to the phorbol ester tumor promoter TPA.
Topics: Animals; Calcimycin; Calcium; Chemotaxis; Egtazic Acid; Gallic Acid; In Vitro Techniques; Macrophages; Male; Mice; Mice, Inbred ICR; Phorbols; Ruthenium Red; Tetradecanoylphorbol Acetate | 1982 |
Effects of 12-O-tetradecanylphorbol 13-acetate (TPA) on a clonal human teratoma-derived embryonal carcinoma cell line.
Topics: alpha-Fetoproteins; Antigens, Surface; Cell Adhesion; Cell Line; Cell Nucleus; Chorionic Gonadotropin; Clone Cells; Cytoskeleton; Fibronectins; HLA Antigens; Humans; Membrane Proteins; Neoplasm Proteins; Organoids; Phorbols; Teratoma; Tetradecanoylphorbol Acetate | 1983 |
Calcium modulation of phorbol ester-induced alterations in murine macrophage morphology.
Topics: Animals; Calcimycin; Calcium; Cell Adhesion; Cell Count; Cytochalasin B; Dose-Response Relationship, Drug; Drug Interactions; Female; Gallic Acid; Macrophages; Mice; Mice, Inbred ICR; Phorbols; Ruthenium Red; Tetradecanoylphorbol Acetate | 1983 |
Phorbolester-treated human lymphocytes are susceptible to natural killer cell-mediated cytolysis.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Humans; Interferons; Killer Cells, Natural; Lymphocytes; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Translation of lymphocyte mRNA for mouse colony stimulating factor.
Topics: Animals; Cell Line; Colony-Stimulating Factors; Lymphocyte Activation; Lymphocytes; Lymphoma; Mice; Neoplasms, Experimental; Phorbols; Poly A; Protein Biosynthesis; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate | 1983 |
Enhanced synthesis of a specific protein by 12-O-tetradecanoylphorbol-13-acetate in cultured chick embryo muscle cells.
Topics: Animals; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Muscle Proteins; Muscles; Phorbols; Protein Biosynthesis; RNA; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
"Dark cells" in normal, hyperplastic, and promoter-treated mouse epidermis studied by conventional and high-voltage electron microscopy.
Topics: Aging; Animals; Epidermal Cells; Epidermis; Female; Hyperplasia; Mice; Microscopy, Electron; Neoplasms, Experimental; Phorbols; Pregnancy; Staining and Labeling; Tetradecanoylphorbol Acetate | 1983 |
[Effect of phorbol ester on hormone-induced differentiation of rat parotid glands in organ culture].
Topics: Adrenal Cortex Hormones; Amylases; Animals; Organ Culture Techniques; Parotid Gland; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1982 |
A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Child; Cholera Toxin; Epidermal Growth Factor; Female; Fetus; Humans; Hydrocortisone; Keratins; Male; Mice; Phorbols; Pregnancy; Simian virus 40; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1983 |
Tumour promoter-mediated reversible inhibition of cell-cell communication (electrical coupling). Relationship with phorbol ester binding and de novo macromolecule synthesis.
Topics: Binding Sites; Cell Communication; Cell Line; Cycloheximide; Dactinomycin; Diterpenes; Electrophysiology; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Biosynthesis; RNA; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Cyclic AMP; Cytotoxicity, Immunologic; Interleukin-2; Kinetics; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate; Theophylline; Thymus Gland | 1983 |
Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promoters on the adipocyte differentiation of 3T3-L1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Alkaloids; Animals; Carcinogens; Cell Differentiation; Dexamethasone; Fibroblasts; Lyngbya Toxins; Mice; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
12-O-tetradecanoylphorbol-13-acetate actions on macromolecular synthesis, ornithine decarboxylase, and cellular differentiation of the rat embryonic visceral yolk sac in culture.
Topics: Animals; Dimethyl Sulfoxide; DNA; DNA Replication; Female; Hemoglobins; Molecular Weight; Organ Culture Techniques; Ornithine Decarboxylase; Phorbols; Pregnancy; Protein Biosynthesis; Proteins; Rats; RNA; Tetradecanoylphorbol Acetate; Transcription, Genetic; Yolk Sac | 1983 |
12-0-tetradecanoylphorbol-13-acetate and concanavalin A enhance glucose uptake in thymocytes by different mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3-O-Methylglucose; Animals; Biological Transport, Active; Bucladesine; Concanavalin A; Deoxy Sugars; Deoxyglucose; Egtazic Acid; Female; Kinetics; Lymphocytes; Methylglucosides; Methylglycosides; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate; Thymus Gland | 1983 |
Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Differentiation; Cell Division; DNA Replication; Electrophoresis, Agar Gel; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Nucleic Acid Hybridization; Oncogenes; Phorbols; RNA; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Activation of bleomycin A2 to a DNA-damaging intermediate by phorbol ester-stimulated human polymorphonuclear leukocytes.
Topics: Biotransformation; Bleomycin; Catalase; Deoxyribose; DNA; Humans; In Vitro Techniques; Neutrophils; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1984 |
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Diethylnitrosamine; Drug Interactions; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Activation and proliferation signals in mouse B cells. I. A comparison of the capacity of anti-Ig antibodies or phorbol myristic acetate to activate B cells from CBA/N or normal mice into G1.
Topics: Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; DNA; Female; Histocompatibility Antigens Class II; Interphase; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred CBA; Phorbols; RNA; Tetradecanoylphorbol Acetate | 1984 |
Quercetin inhibits the action of 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.
Topics: Animals; Cells, Cultured; Chick Embryo; Deoxyglucose; Dimethyl Sulfoxide; Embryo, Mammalian; Flavonoids; Humans; Phorbols; Phosphates; Phospholipids; Platelet Aggregation; Quercetin; RNA; Tetradecanoylphorbol Acetate | 1984 |
Effect of phorbol ester TPA on macrophage metabolic activity.
Topics: Animals; Cell Adhesion; Culture Media; In Vitro Techniques; Leucine; Macrophages; Mice; Phagocytosis; Phorbols; Protein Biosynthesis; RNA; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Trypan Blue; Uridine | 1984 |
Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes.
Topics: Cells, Cultured; Humans; Monocytes; Phorbol Esters; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
A morphometric study of dedifferentiated and involutional dark keratinocytes in 12-O-tetradecanoylphorbol-13-acetate-treated mouse epidermis.
Topics: Animals; Cell Differentiation; Female; Keratins; Mice; Mice, Inbred Strains; Microscopy, Electron; Phorbols; Skin; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1984 |
Non-promoting hyperplasiogenic agents do not mimic the effects of phorbol, 12-myristate, 13-acetate on terminal differentiation of normal and transformed human keratinocytes.
Topics: Alkynes; Calcimycin; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Humans; Hyperplasia; Keratins; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1984 |
Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.
Topics: Amylases; Animals; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Pancreas; Phorbols; Rabbits; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Phorbol ester induces intracellular translocation of phospholipid/Ca2+-dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini.
Topics: Amylases; Animals; Dose-Response Relationship, Drug; Fluphenazine; Male; Pancreas; Phorbols; Polymyxin B; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Influence of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the susceptibility of K562 to natural cytotoxicity: evidence for clonal variation in differentiation-induced changes of lytic sensitivity.
Topics: Cell Differentiation; Cell Line; Chromium Radioisotopes; Clone Cells; Cytotoxicity, Immunologic; Humans; Interferons; Karyotyping; Killer Cells, Natural; Leukemia, Erythroblastic, Acute; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Induction of plasmacytoid differentiation by phorbol ester in B-cell lymphoma cell lines bearing 8;14 translocations.
Topics: B-Lymphocytes; Cell Adhesion; Cell Differentiation; Cell Line; Chromosomes, Human, 13-15; Chromosomes, Human, 6-12 and X; Genes; Humans; Immunoglobulin M; Immunoglobulins; Male; Microscopy, Electron; Phorbols; Plasma Cells; RNA; Tetradecanoylphorbol Acetate; Translocation, Genetic | 1984 |
Differential expression of HLA-DR and HLA-DC/DS molecules in a patient with hairy cell leukemia: restoration of HLA-DC/DS expression by (12-0-tetradecanoyl phorbol-13-acetate), 5 azacytidine, and sodium butyrate.
Topics: Antibodies, Monoclonal; Azacitidine; Butyrates; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Heterozygote; Histocompatibility Antigens Class II; HLA-DQ Antigens; HLA-DR Antigens; Homozygote; Humans; Leukemia, Hairy Cell; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Differential effects of complete and second-stage tumour promoters in normal but not transformed human and mouse keratinocytes.
Topics: Carcinogens; Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Neoplastic; Diterpenes; Drug Resistance; Epidermal Cells; Epidermis; Humans; Keratins; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1984 |
K562 cells induced to differentiate by phorbol ester tumor promotors resist NK lysis.
Topics: Cell Differentiation; Cells, Cultured; Humans; Immunity, Innate; Interferons; Killer Cells, Natural; Neoplasm Proteins; Neoplasms, Experimental; Phorbol Esters; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate | 1984 |
A keratin of fetal skin is reexpressed in human keratinocytes transformed by SV40 virus or treated with the tumor promoter TPA.
Topics: Cell Line; Cell Transformation, Viral; Cells, Cultured; Female; Fetus; Fluorescent Antibody Technique; Humans; Infant, Newborn; Keratins; Male; Molecular Weight; Phorbols; Pregnancy; Simian virus 40; Skin; Tetradecanoylphorbol Acetate | 1984 |
A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Benzimidazoles; Bucladesine; Cell Line; Chlorocebus aethiops; Cytoskeleton; Fluorescent Antibody Technique; Intermediate Filament Proteins; Kidney; Microscopy, Electron; Microtubules; Muscle Proteins; Nocodazole; Phorbols; Tetradecanoylphorbol Acetate; Vimentin; Vinculin | 1984 |
Biochemical effects of 12-O-tetradecanoylphorbol-13-acetate, retinoic acid, phenobarbital, and 5-azacytidine on a normal rat liver epithelial cell line.
Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Fibronectins; Liver; Phenobarbital; Phorbols; Rats; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
[Induction of baboon herpes virus antigens in producing lymphoblastoid cells].
Topics: Animals; Antigens, Viral; Butyrates; Butyric Acid; Cell Division; Cell Line; Cycloheximide; DNA; DNA-Directed DNA Polymerase; Herpesviridae; Herpesvirus 1, Cercopithecine; Herpesvirus 4, Human; Idoxuridine; Lymphocytes; Papio; Phorbols; RNA; Tetradecanoylphorbol Acetate; Virus Activation | 1984 |
Role of lipoxygenases in regulation of PHA and phorbol ester-induced mitogenesis.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Lipoxygenase; Lymphocyte Activation; Lymphocytes; Mice; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Thromboxanes | 1982 |
The effects of retinoic acid and a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, on lymphocyte proliferation.
Topics: Animals; Cattle; Cell Division; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1982 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on fibroblasts from individuals genetically predisposed to cancer.
Topics: Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cytoskeleton; Disease Susceptibility; Down Syndrome; Epidermal Growth Factor; Fanconi Anemia; Female; Fibroblasts; Humans; Intestinal Polyps; Male; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Trypsin; Xeroderma Pigmentosum | 1982 |
Tumor promoter phorbol myristic acetate is a T-cell dependent inducer of immunoglobulin secretion in human lymphocytes.
Topics: Antibody-Producing Cells; B-Lymphocytes; Cell Line; Dose-Response Relationship, Drug; Hemolytic Plaque Technique; Humans; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Lymphocyte Activation; Lymphocytes; Phorbols; Pokeweed Mitogens; T-Lymphocytes; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1982 |
Heterogeneity of the response of chronic lymphocytic leukemia cells to phorbol ester.
Topics: Antigens, Surface; Cell Differentiation; Humans; Leukemia, Lymphoid; Lymphocyte Culture Test, Mixed; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Activation of human T lymphocytes by 12-O-tetradecanoylphorbol-13-acetate: role of accessory cells and interaction with lectins and allogeneic cells.
Topics: Humans; Lectins; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Macrophages; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wheat Germ Agglutinins | 1982 |
Differentiation of human T-lymphoid leukemia cells into cells that have a suppressor phenotype is induced by phorbol 12-myristate 13-acetate.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Cell Line; Humans; Leukemia, Myeloid, Acute; Phorbols; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1982 |
Phorbol myristate acetate and in vitro T lymphocyte function. II. Influence of PMA and supernatants from PMA-treated P388D1 cells on the proliferation of cloned T cells.
Topics: Animals; Clone Cells; Dose-Response Relationship, Immunologic; Female; Interleukin-1; Interleukin-2; Leukemia P388; Leukemia, Experimental; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Activation of calcium and phospholipid-dependent protein kinase by epidermal growth factor (EGF) in A431 cells: attenuation by 12-0-tetradecanoylphorbol-13-acetate (TPA).
Topics: Carcinoma, Squamous Cell; Cell Line; Diglycerides; Drug Antagonism; Epidermal Growth Factor; Humans; Kinetics; Phorbols; Phospholipids; Protein Kinase C; Protein Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Oxygen uptake, ATPase activity, and superoxide dismutase activity in isolated rat liver mitochondria are not influenced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenosine Triphosphatases; Animals; Hydrogen Peroxide; Male; Mitochondria, Liver; Oligomycins; Oxygen Consumption; Phorbols; Rats; Rats, Inbred Strains; Submitochondrial Particles; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin.
Topics: Amyloid beta-Protein Precursor; Carrier Proteins; Cells, Cultured; Epidermal Growth Factor; Fibrinolysin; Fibroblasts; Humans; Mitogens; Phorbols; Plasminogen Activators; Plasminogen Inactivators; Protease Nexins; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thrombin | 1983 |
Tumor promoter TPA increases initiation of replication on DNA injected into xenopus eggs.
Topics: Animals; Bacteriophage lambda; Cell Cycle; Cycloheximide; DNA Replication; Female; Microinjections; Oocytes; Oogenesis; Ovum; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Xenopus laevis | 1983 |
Insulin secretion: combined effects of phorbol ester and A23187.
Topics: Animals; Calcimycin; Calmodulin; Drug Synergism; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Phorbols; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1983 |
B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation.
Topics: Animals; B-Lymphocytes; Cell Cycle; Enzyme Activation; Histocompatibility Antigens Class II; Lymphocyte Activation; Membrane Potentials; Mice; Mice, Inbred BALB C; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester-induced changes in human leukemic pre-B lines.
Topics: Antigens, Neoplasm; B-Lymphocytes; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Humans; Immunoglobulin mu-Chains; Leukemia; Leukemia, Lymphoid; Neprilysin; Phorbols; Stem Cells; Tetradecanoylphorbol Acetate | 1984 |
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenes; Animals; Benz(a)Anthracenes; Dehydroepiandrosterone; Drug Administration Schedule; Drug Antagonism; Estradiol; Female; Mice; Papilloma; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterus | 1984 |
Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells.
Topics: Butyrates; Cell Differentiation; Cell Line; Glycophorins; Glycoproteins; Humans; Leukemia; Megakaryocytes; Phorbols; Platelet Membrane Glycoproteins; Tetradecanoylphorbol Acetate | 1984 |
Steroidogenic properties of phorbol ester and a Ca2+ ionophore in bovine adrenocortical cell suspensions.
Topics: Adrenal Cortex; Animals; Calcimycin; Cattle; Diglycerides; Hydrocortisone; In Vitro Techniques; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester.
Topics: Blood Platelets; Calcium; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Activation; Humans; Phorbols; Phospholipids; Protein Kinase C; Protein Kinases; Solubility; Tetradecanoylphorbol Acetate | 1984 |
12-O-Tetradecanoylphorbol 13-acetate stimulates inositol lipid phosphorylation in intact human platelets.
Topics: Blood Platelets; Enzyme Activation; Humans; Kinetics; Molecular Weight; Phorbols; Phosphates; Phosphatidylinositols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.
Topics: Animals; Diglycerides; Gizzard, Avian; Kinetics; Molecular Weight; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Phorbols; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Turkeys | 1984 |
Phorbol ester treated chronic B lymphocytic leukaemia cells induce autologous T cell proliferation without generation of cytotoxic T cells.
Topics: B-Lymphocytes; Cytotoxicity Tests, Immunologic; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Induction of expression and phosphorylation of the human interleukin 2 receptor by a phorbol diester.
Topics: Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Glycoside Hydrolases; Humans; Leukemia; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Neuraminidase; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Immunologic; Receptors, Interleukin-2; Tetradecanoylphorbol Acetate; Trypsin; Tunicamycin | 1984 |
TMB-8 inhibits secretion evoked by phorbol ester at basal cytoplasmic free calcium in quin2-loaded platelets much more effectively than it inhibits thrombin-induced calcium mobilisation.
Topics: Aminoquinolines; Blood Platelets; Calcium; Calcium Channel Blockers; Collagen; Fluorescent Dyes; Gallic Acid; Humans; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Thrombin | 1984 |
Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter.
Topics: Animals; Brain; Calcium; Egtazic Acid; Kinetics; Oligopeptides; Phorbols; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate | 1984 |
Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds.
Topics: Animals; Calcium; Cytosol; Enzyme Activation; Female; Kinetics; Lipoxygenase; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Skin; Tetradecanoylphorbol Acetate | 1984 |
Effect of the diterpene ester TPA on Epstein-Barr virus antigen- and DNA synthesis in producer and nonproducer cell lines.
Topics: Antigens, Viral; Capsid; Cell Line; DNA, Viral; Herpesvirus 4, Human; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Activity and activation of the granulocyte superoxide-generating system.
Topics: Adenosine Triphosphate; Animals; Cations, Divalent; Deoxyglucose; Dose-Response Relationship, Drug; Ethylmaleimide; Granulocytes; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Oxygen; Phagocytosis; Phorbols; Superoxides; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Zymosan | 1980 |
Antagonism between phorbol myristate acetate and butyric acid on isoproterenol elevation of cyclic adenosine 3':5'-monophosphate and their effects on beta-adrenergic receptors in mouse epidermis.
Topics: Animals; Butyrates; Cyclic AMP; Female; Isoproterenol; Mice; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Tetradecanoylphorbol Acetate | 1980 |
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxy-Lyases; Cyclooxygenase Inhibitors; Female; Indomethacin; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Prostaglandins; Prostaglandins E, Synthetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.
Topics: Catalase; Granulocytes; Granulomatous Disease, Chronic; Humans; Membrane Potentials; Oxygen; Phorbols; Potassium; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Valinomycin | 1980 |
Phorbol ester-mediated stimulation of the synthesis of mouse mammary tumour virus.
Topics: Animals; Cells, Cultured; Female; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Nucleic Acid Hybridization; Phorbols; RNA, Viral; Tetradecanoylphorbol Acetate; Virus Replication | 1980 |
Effect of inhibition of DNA synthesis on Epstein--Barr virus induction by tumor promoters.
Topics: Antigens, Viral; Cytarabine; DNA; Floxuridine; Herpesvirus 4, Human; Humans; Idoxuridine; Phorbols; Tetradecanoylphorbol Acetate; Virus Activation | 1980 |
Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA.
Topics: Animals; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; Glycoproteins; Kirsten murine sarcoma virus; Mice; Phorbols; Protein Biosynthesis; RNA, Messenger; Sarcoma Viruses, Murine; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Tumour promoter uncouples beta-adrenergic receptor from adenyl cyclase in mouse epidermis.
Topics: Adenylyl Cyclases; Animals; Cell-Free System; Cyclic AMP; Enzyme Activation; Epidermis; Female; Guanosine Triphosphate; Isoproterenol; Membrane Fluidity; Mice; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1980 |
Phorbol ester action is independent of viral and cellular src kinase levels.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Fibroblasts; Genes, Viral; Phenotype; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1980 |
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
Topics: Animals; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Macrophages; Mice; Monocytes; Phorbol Esters; Phorbols; Receptors, Cell Surface; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Induction of Epstein-Barr virus-associated DNA polymerase by 12-O-tetradecanoylphorbol-13-acetate. Purification and characterization.
Topics: Acyclovir; Antiviral Agents; Burkitt Lymphoma; Cell Line; DNA Polymerase I; DNA Polymerase II; DNA-Directed DNA Polymerase; Enzyme Induction; Ethylmaleimide; Guanine; Herpesvirus 4, Human; Humans; Kinetics; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate | 1980 |
Diurnal variation in cyclic nucleotide levels in normal and phorbol myristate acetate treated mouse epidermis.
Topics: Animals; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Female; Mice; Nucleotides, Cyclic; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1980 |
Reactivation of ribosomal RNA genes in human-mouse hybrid cells by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Cell Transformation, Viral; Genes; Humans; Hybrid Cells; Mice; Phorbol Esters; Phorbols; RNA, Ribosomal; Simian virus 40; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1980 |
Alteration of cyclic nucleotide levels in phorbol 12-myristate 13-acetate treated myoblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminophylline; Animals; Biological Transport, Active; Cells, Cultured; Chick Embryo; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Deoxyglucose; Kinetics; Muscles; Phorbols; Tetradecanoylphorbol Acetate; Theophylline | 1980 |
Mitogenic effect of 12-0 tetradecanoyl phorbol 13-acetate on non-human primate mononuclear cells and in vitro interaction with Epstein-Barr virus transformation.
Topics: Animals; Callitrichinae; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Haplorhini; Herpesvirus 4, Human; Lymphocyte Activation; Lymphocytes; Macaca mulatta; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1980 |
Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells.
Topics: Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Endothelium; Humans; Microbial Collagenase; Phorbols; Plasminogen Activators; Plasminogen Inactivators; Tetradecanoylphorbol Acetate | 1980 |
Changes in epidermal growth factor receptors associated with adenovirus transformation, chemical carcinogen transformation and exposure to a phorbol ester tumor promoter.
Topics: Adenoviruses, Human; Animals; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; Mice; Peptides; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1980 |
Increased infectivity of oncogenic herpes viruses of primates with tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Antigens, Viral; Cell Line; Dose-Response Relationship, Drug; Haplorhini; Herpesviridae Infections; Herpesvirus 2, Saimiriine; Herpesvirus 4, Human; Humans; Phorbols; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Viral Plaque Assay | 1980 |
Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Cyclic AMP; Kinetics; Melanins; Melanoma; Mice; Neoplasms, Experimental; Phorbols; Protein Kinase Inhibitors; Saccharin; Tetradecanoylphorbol Acetate | 1980 |
Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia.
Topics: Cell Adhesion; Cell Differentiation; Histocytochemistry; Humans; Leukemia, Myeloid, Acute; Macrophages; Muramidase; Naphthol AS D Esterase; Nitroblue Tetrazolium; Peroxidase; Phagocytosis; Phorbols; Sodium Fluoride; Tetradecanoylphorbol Acetate | 1980 |
Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets.
Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Ionophores; Islets of Langerhans; Phorbols; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate.
Topics: Humans; Hydrogen-Ion Concentration; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phorbols; Spectrometry, Fluorescence; Substrate Specificity; Superoxides; Tetradecanoylphorbol Acetate | 1980 |
Prostaglandin E-mediated mitogenic stimulation of mouse epidermis in vivo by divalent cation ionophore A 23187 and by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Anti-Bacterial Agents; Calcimycin; Catecholamines; Cyclic AMP; Enzyme Induction; Epidermal Cells; Epidermis; Inflammation; Mast Cells; Mice; Mitosis; Phorbols; Prostaglandins E; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1981 |
Purification of plasminogen activator from Rous sarcoma virus transformed chick embryo fibroblasts treated with the tumor promoter phorbol 12-myristate 13-acetate.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Molecular Weight; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1980 |
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Female; Fetus; Leukemia; Liver Neoplasms; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Ovarian Diseases; Phorbols; Pregnancy; Prostaglandins; Radiation, Ionizing; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1980 |
Retinoid inhibition of superoxide anion radical production by human polymorphonuclear leukocytes stimulated with tumor promoters.
Topics: Alkaloids; Antipain; Cocarcinogenesis; Diterpenes; Humans; Indoles; Inflammation; Lyngbya Toxins; Neutrophils; Oxygen; Phorbol Esters; Phorbols; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1980 |
Functionally deficient differentiation of HL-60 promyelocytic leukemia cells induced by phorbol myristate acetate.
Topics: Cell Differentiation; Complement System Proteins; Humans; Leukemia, Myeloid, Acute; Macrophages; Nucleotidases; Oxygen Consumption; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors.
Topics: Alkaloids; Animals; Arachidonic Acids; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Epidermal Growth Factor; ErbB Receptors; Kinetics; Lyngbya Toxins; Mice; Phorbols; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Induction of replication of Epstein-Barr virus DNA by 12-O-tetradecanoyl-phorbol-13-acetate. II. Inhibition by retinoic acid and 9-(2-hydroxyethoxymethyl) guanine.
Topics: Acyclovir; Cell Line; DNA Replication; DNA, Viral; Guanine; Herpesvirus 4, Human; Humans; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Virus Replication | 1981 |
Chemotactic factor enhancement of superoxide release from fluoride and phorbol myristate acetate stimulated neutrophils.
Topics: Chemotactic Factors; Enzyme Activation; Fluorides; Humans; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Oxygen; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1981 |
Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters.
Topics: Humans; In Vitro Techniques; Neoplasms; Neutrophils; Oxygen; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1981 |
Induction of type-C retrovirus by the tumor promotor TPA.
Topics: Animals; Antipain; Cell Line; Dose-Response Relationship, Drug; Leupeptins; Mice; Mice, Inbred BALB C; Oligopeptides; Phorbols; Protease Inhibitors; Retroviridae; Tetradecanoylphorbol Acetate; Virus Replication | 1981 |
The modulating effect of retinoids and a tumor promoter on malignant transformation, sister chromatid exchanges, and Na/K ATPase.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Crossing Over, Genetic; Mice; Mice, Inbred C3H; Phorbols; Sister Chromatid Exchange; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Vitamin A | 1981 |
Phorbol ester stimulation of Na influx and Na-K pump activity in Swiss 3T3 cells.
Topics: Animals; Biological Transport, Active; Carcinogens; Cells, Cultured; Kinetics; Mice; Mice, Inbred Strains; Monensin; Ouabain; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate | 1981 |
Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells.
Topics: Antigens, Viral; Capsid; Cells, Cultured; Croton Oil; Drug Interactions; Herpesvirus 4, Human; Humans; Lymphocytes; Phorbols; Plant Extracts; Tetradecanoylphorbol Acetate; Virus Activation | 1981 |
Growth state-dependent alterations in the ability of 12-O-tetradecanoylphorbol-13-acetate to increase ornithine decarboxylase activity in Reuber h35 Hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Cell Line; Dexamethasone; DNA; Enzyme Induction; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Inhibition of epidermal growth factor binding to mouse embryonal carcinoma cells by phorbol esters mediated by specific phorbol ester receptors.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neoplasms, Experimental; Peptides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Teratoma; Tetradecanoylphorbol Acetate | 1981 |
Effects of 12-O-tetradecanoyl phorbol 13-acetate on platelet aggregation.
Topics: Aspirin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Phorbols; Phosphorylation; Platelet Aggregation; Serotonin; Tetradecanoylphorbol Acetate | 1981 |
Histone phosphorylation in phorbol ester stimulated and beta-adrenergically stimulated mouse epidermis in vivo and characterization of an epidermal protein phosphorylation system.
Topics: Animals; Casein Kinases; Epidermis; Female; Histones; Isoproterenol; Mice; Phorbols; Phosphoprotein Phosphatases; Phosphorylation; Protamine Kinase; Protein Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1981 |
12-O- tetradecanoylphorbol- 13 acetate (TPA) treatment elevates the natural killer (NK) sensitivity of certain human lymphoid lines.
Topics: Antigens; B-Lymphocytes; Burkitt Lymphoma; Cell Line; Chromium Radioisotopes; Cytotoxicity, Immunologic; Herpesvirus 4, Human; Humans; Kinetics; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Glucocorticoids and benzo(a)pyrene had opposing effects on EGF receptor binding.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; ErbB Receptors; Fluocinolone Acetonide; Glucocorticoids; Mice; Phorbols; Receptors, Cell Surface; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Enhancement of outgrowth of EB virus-transformed cells from normal human peripheral blood by a tumor promoter, TPA.
Topics: Adult; Antibodies, Viral; B-Lymphocytes; Cell Line; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Mechanisms of enhancement of Epstein-Barr virus-induced transformation of peripheral blood lymphocytes by a tumor promoter, TPA, with special reference to lowering of cytotoxicity of T cells.
Topics: Adult; Antigens, Viral; Autoradiography; Cell Transformation, Viral; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; DNA; Herpesvirus 4, Human; Humans; Infant, Newborn; Lymphocyte Activation; Lymphocytes; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol).
Topics: Animals; Cells, Cultured; Dexamethasone; Dinoprostone; Enzyme Induction; Fibroblasts; Microbial Collagenase; Phorbols; Polyethylene Glycols; Prednisolone; Prostaglandins E; Rabbits; Synovial Fluid; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate.
Topics: Biological Transport; Caenorhabditis elegans Proteins; Carrier Proteins; Humans; Kinetics; Neutrophils; Oxygen; Phorbols; Protein Kinase C; Receptors, Drug; Superoxides; Tetradecanoylphorbol Acetate | 1981 |
Phorbol esters induce synthesis of thromboplastin activity in human monocytes.
Topics: Apoproteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Monocytes; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Thromboplastin | 1981 |
Steroids inhibit tumor promoting agent induced Epstein-Barr virus early antigens in Raji cells.
Topics: Adrenal Cortex Hormones; Antigens, Viral; B-Lymphocytes; Burkitt Lymphoma; Cell Line; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Phorbols; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone | 1981 |
Modulation of human T-cell differentiation markers by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Adult; Animals; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Cytarabine; DNA; DNA Nucleotidylexotransferase; Histocompatibility Antigens Class II; Humans; Leukemia, Experimental; Nucleotidases; Phorbols; Phytohemagglutinins; Rosette Formation; Sheep; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Epstein-Barr virus-induced early polypeptides in Raji and NC37 cells activated by diterpene ester TPA in combination with N-butyrate.
Topics: Butyrates; Cell Line; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Molecular Weight; Peptides; Phorbols; Tetradecanoylphorbol Acetate; Viral Proteins | 1981 |
Induction of Epstein-Barr virus by an new tumor promoter, teleocidin, compared to induction by TPA.
Topics: Alkaloids; Antigens, Viral; Cell Line; Cell Transformation, Viral; Cells, Cultured; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Lymphocytes; Lyngbya Toxins; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Virus Activation | 1981 |
The relationship between tumor promoter binding and Epstein-Barr virus induction in human lymphoblastoid cell lines.
Topics: Blood; Cell Line; Herpesvirus 4, Human; Humans; Kinetics; Lymphocytes; Phorbols; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Virus Activation | 1981 |
DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate.
Topics: Cell Survival; Cells, Cultured; Cocarcinogenesis; DNA; Free Radicals; Humans; Kinetics; Leukocytes; Oxygen Consumption; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1982 |
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.
Topics: Carcinoma; Cell Line; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Freezing; Humans; Kinetics; Macromolecular Substances; Mouth Neoplasms; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate: effect on complement and Epstein-Barr virus receptors in human lymphoblastoid cell lines.
Topics: Burkitt Lymphoma; Cell Line; Herpesvirus 4, Human; Humans; Kinetics; Leukemia; Lymphoma; Phorbols; Receptors, Complement; Receptors, Virus; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Effects of 12-O-tetradecanoyl-phorbol-13-acetate on cell proliferation and Epstein-Barr virus DNA replication.
Topics: Animals; Burkitt Lymphoma; Cell Division; Cell Line; DNA Replication; DNA, Viral; Herpesvirus 4, Human; Humans; Hybrid Cells; Mice; Phorbols; Tetradecanoylphorbol Acetate; Virus Activation; Virus Replication | 1982 |
[Phorbol ester-induced expression of primate retroviruses (author's transl)].
Topics: Cell Line; Cell Transformation, Viral; Humans; Phorbols; Retroviridae; Tetradecanoylphorbol Acetate | 1981 |
Interaction of tumor promoters and growth factors with cultured cells.
Topics: Animals; Cell Line; Cells, Cultured; DNA; Drug Synergism; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblasts; Kinetics; Mice; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of epidermal growth factor binding by phorbol esters, saccharin, and cyclamate and its implications in the mechanism of tumor promotion.
Topics: Carcinogens; Cocarcinogenesis; Cyclamates; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Phorbols; Receptors, Cell Surface; Saccharin; Structure-Activity Relationship; Temperature; Tetradecanoylphorbol Acetate | 1982 |
A possible role of protein alkylation in phorbol ester action.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alkylation; Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Choline-Phosphate Cytidylyltransferase; Enzyme Activation; Lymphocyte Activation; Lymphocytes; Nucleotidyltransferases; Oxygen; Phorbols; Phosphatidylcholines; Phytohemagglutinins; Proteins; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Spin-labeled phorbol esters and their interaction with cellular membranes.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Erythrocytes; Irritants; Kinetics; Mice; Phorbols; Spin Labels; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Phorbol myristate acetate uncouples the relationship between beta-adrenergic receptors and adenyl cyclase in mouse epidermis: a phenotypic trait in papillomas.
Topics: Adenylyl Cyclases; Animals; Cocarcinogenesis; Cyclic GMP; Enzyme Activation; Epidermis; Isoproterenol; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
The role of free oxygen radicals in tumor promotion and carcinogenesis.
Topics: Carcinogens; Cell Membrane; Cocarcinogenesis; Diterpenes; Free Radicals; Hydrogen Peroxide; Neutrophils; Oxygen; Phorbol Esters; Phorbols; Protease Inhibitors; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Vitamin A | 1982 |
Effect of tumor promoters in immunological systems--the macrophage as a target cell for the action of phorbol esters.
Topics: Animals; Calcium; Cell Movement; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; Cytotoxicity, Immunologic; Glutathione; Hydrogen Peroxide; Macrophages; Malondialdehyde; Mice; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1982 |
Protease inhibitors from processed legumes effectively inhibit superoxide generation in response to TPA.
Topics: Fabaceae; Free Radicals; Glycine max; Humans; Neutrophils; Oxygen; Phorbols; Plants, Medicinal; Protease Inhibitors; Superoxides; Tetradecanoylphorbol Acetate | 1982 |
Decreased accumulation of cyclic adenosine 3',5'-monophosphate in "ischemic" skin after 12-0-tetradecanoyl-phorbol-13-acetate treatment.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetone; Adenosine; Animals; Cyclic AMP; Dinoprostone; Female; Histamine; In Vitro Techniques; Ischemia; Isoproterenol; Mice; Phorbols; Prostaglandins E; Skin; Tetradecanoylphorbol Acetate | 1982 |
Effect of cyclooxygenase inhibitors and protease inhibitors on phorbol-induced stimulation of oxygen consumption and superoxide production by rat pulmonary macrophages.
Topics: Animals; Aspirin; Ibuprofen; In Vitro Techniques; Lung; Macrophages; Oxygen; Oxygen Consumption; Oxygenases; Phorbols; Protease Inhibitors; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1982 |
Enhancement of hormone action by a phorbol ester and anti-tubulin alkaloids involves different mechanisms.
Topics: Alprostadil; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Clone Cells; Cyclic AMP; Diterpenes; Isoproterenol; Kinetics; Leukemia, Experimental; Mice; Phorbol Esters; Phorbols; Prostaglandins E; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils.
Topics: Calcium; Chlortetracycline; Concanavalin A; Egtazic Acid; Gallic Acid; Glucuronidase; Humans; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phorbols; Spectrometry, Fluorescence; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate; Trifluoperazine; Vasodilator Agents | 1982 |
Alterations of glial tumor cell Ca2+ metabolism and Ca2+-dependent cAMP accumulation by phorbol myristate acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Biological Transport, Active; Calcium; Cell Line; Cholera Toxin; Cyclic AMP; Glioma; Kinetics; Neoplasms, Experimental; Norepinephrine; Phorbols; Rats; Tetradecanoylphorbol Acetate; Trifluoperazine | 1982 |
Comparison of the effects of age and phorbol myristate acetate on the beta-adrenergic system in mouse epidermis.
Topics: Aging; Animals; Cyclic AMP; Epidermis; Female; Isoproterenol; Mice; Mice, Inbred ICR; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Increased level of translatable collagenase messenger ribonucleic acid in rabbit synovial fibroblasts treated with phorbol myristate acetate or crystals of monosodium urate monohydrate.
Topics: Amanitins; Animals; Cells, Cultured; Enzyme Induction; Fibroblasts; Microbial Collagenase; Phorbols; Protein Biosynthesis; Rabbits; RNA, Messenger; Synovial Fluid; Tetradecanoylphorbol Acetate; Uric Acid | 1982 |
Reversal of the promotional effect of 12-O-tetradecanoylphorbol-13-acetate on morphological transformation of hamster embryo cells by glucocorticoids.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Corticosterone; Cricetinae; Dexamethasone; Embryo, Mammalian; Glucocorticoids; Hydrocortisone; Mesocricetus; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effect of phorbol myristate acetate and a lymphokine on cyclic 3':5'-guanosine monophosphate levels and proliferation of macrophages.
Topics: Animals; Cell Division; Cyclic GMP; Guinea Pigs; Kinetics; Lymphokines; Macrophage Activation; Macrophage-Activating Factors; Macrophages; Male; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Clone Cells; Drug Resistance; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin; Tetradecanoylphorbol Acetate | 1982 |
Specific high-affinity binding of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate to isolated nuclei and nuclear macromolecules in mouse epidermis.
Topics: Animals; Binding Sites; Cell Fractionation; Cell Nucleus; Chromatin; Deoxyribonuclease I; Deoxyribonucleases; DNA; Endonucleases; Epidermis; Female; Mice; Phorbols; Proteins; Tetradecanoylphorbol Acetate | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; Injections, Intraperitoneal; Methylcholanthrene; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Induction of ornithine decarboxylase in hamster tracheal epithelial cells exposed to asbestos and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Asbestos; Asbestos, Crocidolite; Asbestos, Serpentine; Bucladesine; Carboxy-Lyases; Cell Division; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Enzyme Induction; Epithelium; Ferric Compounds; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Trachea | 1982 |
Effect of retinoic acid and 12-O-tetradecanoyl phorbol-13-acetate on the binding of epidermal growth factor to its cellular receptors.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred C3H; Phorbols; Receptors, Cell Surface; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1982 |
Epidermal growth factor and phorbol ester actions on human osteosarcoma cells. Characterization of response and nonresponsive cell lines.
Topics: Calcium; Cell Line; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Humans; Osteosarcoma; Phorbol Esters; Phorbols; Prostaglandins E; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Pretreatment with phorbol myristate acetate inhibits macrophage activity against intracellular protozoa.
Topics: Animals; Depression, Chemical; Eukaryota; Leishmania; Lymphokines; Macrophages; Male; Mice; Peroxides; Phagocytosis; Phorbols; Superoxides; Tetradecanoylphorbol Acetate; Toxoplasma; Trypanosoma cruzi | 1982 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the differentiation of simian virus 40-infected human keratinocytes.
Topics: Cell Differentiation; Cell Division; Cell Transformation, Viral; Cells, Cultured; Humans; Infant, Newborn; Kinetics; Male; Phorbols; Simian virus 40; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Cholera Toxin; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Induction; Female; Mutation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1982 |
Diversity of nuclear phorbol ester tumor promoter receptors in mouse liver: evidence for two classes of binding sites.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Nucleus; Female; Kinetics; Liver; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate.
Topics: Ascorbic Acid; Disulfiram; Ditiocarb; DNA; Glucose; Humans; In Vitro Techniques; Leukocyte Count; Leukocytes; Oxidation-Reduction; Phorbols; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 1982 |
Promotional effect of different phorbol esters on morphological transformation of hamster embryo cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cricetinae; Embryo, Mammalian; Mesocricetus; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
[Transformation of Chinese hamster cells by plasmid pBR325::tk::HS3 and the effect on transformant stability of tumor promotor TPA].
Topics: Animals; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; DNA Restriction Enzymes; DNA, Satellite; DNA, Viral; Humans; Mitomycins; Operon; Phorbols; Plasmids; Simplexvirus; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transformation, Genetic | 1982 |
Transmembrane potential variations accompanying the PMA-triggered O-2 and H2O2 release by mouse peritoneal macrophages.
Topics: Animals; Egtazic Acid; Hydrogen Peroxide; Macrophages; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxygen; Phorbols; Spectrometry, Fluorescence; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Mechanisms of tumour cell destruction by PMA-activated human neutrophils.
Topics: Burkitt Lymphoma; Carmustine; Cell Line; Chlorides; Cytotoxicity, Immunologic; Humans; Hydrogen Peroxide; Iodides; Neutrophils; Peroxidase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Comparison of the calcium ionophore and phorbol myristate acetate on the initiation of the respiratory burst in human neutrophils.
Topics: Anti-Bacterial Agents; Calcimycin; Dose-Response Relationship, Drug; Glucose; Humans; Luminescent Measurements; Neutrophils; Oxygen Consumption; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1982 |
Modulation of adenovirus transformation by thyroid hormone.
Topics: Adenoviruses, Human; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Cell Transformation, Viral; Cells, Cultured; Phorbols; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate; Triiodothyronine | 1983 |
Tumor promoter binding to rat mammary cell cultures: role of receptors in the inhibition of dome formation.
Topics: Animals; Binding, Competitive; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Female; Mammary Neoplasms, Experimental; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
The presence of p53 transformation-related protein in Ab-MuLV transformed cells is required for their development into lethal tumors in mice.
Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Female; Leukemia Virus, Murine; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phorbols; Phosphoproteins; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1983 |
Specific desensitization to tumor-promoting phorbol esters in mouse pituitary cells. Evidence that desensitization is a two-step process.
Topics: Adrenocorticotropic Hormone; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pituitary Neoplasms; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Cyclic AMP and tumor promoters cause differential induction of ornithine decarboxylase and accumulation of putrescine in Chinese hamster ovary cells deficient in cyclic AMP-dependent protein kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carboxy-Lyases; Cell Line; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Induction; Female; Ornithine Decarboxylase; Ovary; Phorbols; Protein Kinases; Putrescine; Tetradecanoylphorbol Acetate | 1983 |
Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism.
Topics: Alkaloids; Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Kinetics; Lactones; Lyngbya Toxins; Marine Toxins; Mice; Mollusk Venoms; Phorbols; Phospholipids; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Kinetics and concentration effects of TPA-induced differentiation of cultured human neuroblastoma cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Differentiation; Cell Line; Humans; Kinetics; Neuroblastoma; Norepinephrine; Phorbols; Phosphopyruvate Hydratase; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Effect of transmethylation-reaction and increased levels of cAMP on superoxide generation of guinea-pig macrophages induced with wheat germ agglutinin and phorbor myristate.
Topics: Animals; Bucladesine; Cyclic AMP; Dinoprostone; Guinea Pigs; Lectins; Macrophages; Methylation; Oxygen; Phorbols; Prostaglandins E; Superoxides; Tetradecanoylphorbol Acetate; Tubercidin; Wheat Germ Agglutinins | 1983 |
The stimulation of superoxide anion production in guinea-pig peritoneal macrophages and neutrophils by phorbol myristate acetate, opsonized zymosan and IgG2-containing soluble immune complexes.
Topics: Animals; Antigen-Antibody Complex; Female; Guinea Pigs; Immunoglobulin G; Luminescent Measurements; Macrophages; Male; Neutrophils; Opsonin Proteins; Oxygen; Phorbols; Receptors, Fc; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1983 |
Control of endogenous cell regulators by the second-stage tumor promoter phorbol-12-retinoate 13-acetate.
Topics: Animals; Binding, Competitive; Cell Differentiation; Cells, Cultured; Cyclic AMP; Glycoproteins; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Leukemia, Myeloid; Lymphokines; Mice; Muramidase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate | 1983 |
Activation of latent Epstein-Barr virus genomes: selective stimulation of synthesis of chromosomal proteins by a tumor promoter.
Topics: Cell Division; Chromosomal Proteins, Non-Histone; DNA Replication; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Virus Activation; Virus Replication | 1983 |
Binding of phorbol dibutyrate and epidermal growth factor to cultured human epidermal cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate, like epidermal growth factor, stimulates cell proliferation and inhibits differentiation of mouse mammary epithelial cells in culture.
Topics: Animals; Caseins; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Epidermal Growth Factor; Female; Mammary Glands, Animal; Mice; Phorbols; Prolactin; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
Ox erythrocyte cytotoxicity by phorbol myristate acetate-activated human neutrophils.
Topics: Animals; Cattle; Child; Child, Preschool; Cytotoxicity, Immunologic; Erythrocytes; Female; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Male; Neutrophils; Oxygen; Peroxidase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Major EB virus-specific cytoplasmic transcripts in a cellular clone of the HR-1 Burkitt lymphoma line during latency and after induction of viral replicative cycle by phorbol esters.
Topics: Animals; Burkitt Lymphoma; Clone Cells; DNA Replication; DNA, Viral; Herpesvirus 4, Human; Kinetics; Phorbols; RNA, Viral; Tetradecanoylphorbol Acetate; Transcription, Genetic; Virus Replication | 1983 |
[Promoting action of tetradecanoylphorbol acetate on the phenotypic expression of the mutation for the acquisition of resistance to diphtheria toxin in cultured human cells].
Topics: Benzo(a)pyrene; Benzopyrenes; Cell Line; Cells, Cultured; Diphtheria Toxin; Drug Resistance; Epithelium; Female; Humans; In Vitro Techniques; Mutation; Phenotype; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate | 1982 |
Teleocidin is not mitogenic for 12-O-tetradecanoylphorbol-13-acetate non-proliferative variants of 3T3 cells.
Topics: Alkaloids; Animals; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Genetic Variation; Lyngbya Toxins; Mice; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
The comparative effects of tumor-related agents on developmental marker expression in presumptive myoblasts and myotubes.
Topics: Animals; Avian Sarcoma Viruses; Cell Differentiation; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Isoenzymes; Muscle Proteins; Muscles; Phorbols; Phosphoproteins; Pyruvate Kinase; Tetradecanoylphorbol Acetate; Tropomyosin | 1983 |
Alteration of calcium transport by tumor promoters, 12-O-tetradecanoyl phorbol-13-acetate and p,p'-dichlorodiphenyltrichloroethane, in the Chinese hamster V79 fibroblast cell line.
Topics: Animals; Calcium; Cell Communication; Cell Line; Cricetinae; Cricetulus; DDT; Fibroblasts; Intercellular Junctions; Ion Channels; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
The nature of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated hemopoiesis, colony stimulating factor (CSF) requirement for colony formation, and the effect of TPA on [125I]CSF-1 binding to macrophages.
Topics: Animals; Cell Line; Colony-Forming Units Assay; Colony-Stimulating Factors; Drug Synergism; Hematopoiesis; Macrophages; Mice; Phorbols; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Tetradecanoylphorbol Acetate | 1983 |
Quantitative analysis of the cooperative effect between inducers of Epstein-Barr virus antigen synthesis.
Topics: Antigens, Viral; Burkitt Lymphoma; Butyrates; Butyric Acid; Cell Line; Herpesvirus 4, Human; Humans; Idoxuridine; Immunoglobulin M; Kinetics; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
The role of phorbol ester receptor binding in responses to promoters by mouse and human cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Line; Clone Cells; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin; Tetradecanoylphorbol Acetate | 1983 |
Investigation of a possible role for superoxide anion production in tumour promotion.
Topics: Animals; Cricetinae; Cricetulus; Humans; Leukocytes; Lung; Oxygen; Phorbols; Rats; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
An inhibitory effect of tumour promoters on human epithelial cell growth can be dissociated from an effect on junctional communication.
Topics: Breast Neoplasms; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Communication; Cell Division; Cell Line; Cell Transformation, Viral; Epidermal Cells; Epidermis; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Differential cytotoxicity of tumour promoter TPA for EBV-negative human lymphoma cell lines and their EBV-converted sublines.
Topics: Cell Division; Cell Line; Cell Transformation, Viral; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Lymphoma; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Tumor-promoting phorbol esters inhibit the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages.
Topics: Animals; Ascitic Fluid; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Kinetics; Macrophages; Mice; Mice, Inbred C3H; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Temperature; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate stimulates simian virus 40 induction by DNA-damaging agents and tumor initiators.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Cricetinae; Mesocricetus; Mitomycin; Mitomycins; Phorbols; Simian virus 40; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Virus Activation | 1983 |
[Secretion of two different monokines. Effect of TPA and silica].
Topics: Animals; Cell Line; Female; Kinetics; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Monokines; Phorbols; Proteins; Rats; Rats, Inbred Strains; Silicon Dioxide; Species Specificity; Tetradecanoylphorbol Acetate | 1983 |
Solubilization, purification, and reconstitution of a phorbol ester receptor from the particulate protein fraction of mouse brain.
Topics: Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Female; Kinetics; Mice; Phorbol Esters; Phorbols; Phospholipids; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Solubility; Tetradecanoylphorbol Acetate | 1983 |
Protein kinase activity associated with a phorbol ester receptor purified from mouse brain.
Topics: Animals; Brain; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Female; Kinetics; Magnesium; Mice; Phorbol Esters; Phorbols; Protamine Kinase; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of beta-adrenergic response in cultured epidermal cells by phorbol myristate acetate.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Isoproterenol; Mice; Mice, Inbred C57BL; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1983 |
Effect of 12-O-tetradecanoyl-phorbol-13-acetate on beta-adrenergic receptors of newborn mouse skin.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Enzyme Activation; Isoproterenol; Mice; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Tetradecanoylphorbol Acetate | 1982 |
Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA.
Topics: Acid Phosphatase; Antigens, Surface; Cell Adhesion; Cell Line; Erythrocytes; Esterases; Globins; Glycoproteins; Humans; Leukemia, Erythroblastic, Acute; Macrophages; Phagocytosis; Phenotype; Phorbols; Receptors, Cell Surface; Receptors, LDL; Tetradecanoylphorbol Acetate | 1983 |
Soluble phorbol ester binding sites in cytosol of chick liver and brain--activation by phosphatidylserine.
Topics: Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Chickens; Cytosol; Erythrocytes; Liver; Phorbols; Phosphatidylserines; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Alteration of phenotype of 'regressor' avian sarcoma cells following treatment with phorbol ester.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Chickens; Female; Fibroblasts; Fluorescent Antibody Technique; Male; Phenotype; Phorbols; Sarcoma, Avian; Tetradecanoylphorbol Acetate | 1983 |
Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cells, Cultured; Female; Hydrogen Peroxide; Kinetics; Macrophages; Mice; Mice, Inbred Strains; Mycobacterium bovis; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Organization of the Epstein-Barr virus DNA molecule. III. Location of the P3HR-1 deletion junction and characterization of the NotI repeat units that form part of the template for an abundant 12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcript.
Topics: Base Sequence; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Herpesvirus 4, Human; Phorbols; Repetitive Sequences, Nucleic Acid; RNA, Messenger; RNA, Viral; Templates, Genetic; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1983 |
Phorbol ester-stimulated murine myelopoiesis: role of colony-stimulating factors.
Topics: Animals; Antigen-Antibody Complex; Bone Marrow; Cells, Cultured; Colony-Stimulating Factors; Hematopoiesis; Mice; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Humans; Phorbol Esters; Phorbols; Phosphatidylinositols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
12-O-tetradecanoyl-phorbol-13-acetate enhancement of the tumorigenic potential of herpes simplex virus type 2 transformed cells.
Topics: Animals; Cell Division; Cell Transformation, Viral; Cocarcinogenesis; Neoplasms, Experimental; Phorbols; Rats; Simplexvirus; Tetradecanoylphorbol Acetate | 1983 |
The production of oxygen-centered radicals by bacillus-Calmette-Guerin-activated macrophages. An electron paramagnetic resonance study of the response to phorbol myristate acetate.
Topics: Animals; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxides; Hydroxyl Radical; Kinetics; Macrophage Activation; Macrophages; Mice; Mycobacterium bovis; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
Effects of repeated treatment of hamster ear epidermis and cheek-pouch mucosa with 12-0-tetradecanoylphorbol-13-acetate.
Topics: Amino Acids; Animals; Cricetinae; Cyclic AMP; Epinephrine; Glycolysis; Mitosis; Mouth Mucosa; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by sweetening agents and related compounds.
Topics: Animals; Antigens, Viral; Cells, Cultured; Female; Herpesvirus 4, Human; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Skin; Sweetening Agents; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Specific binding, stimulation of rodent urinary bladder epithelial ornithine decarboxylase, and induction of transitional cell hyperplasia by the skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinoma, Transitional Cell; Carrier Proteins; Female; Hyperplasia; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate; Urinary Bladder; Urinary Bladder Neoplasms | 1983 |
Prostaglandins, cyclic nucleotides and the effect of phorbol ester tumor promoters on mouse skin in vivo.
Topics: Animals; Cyclic AMP; Female; Isoproterenol; Kinetics; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Prostaglandins; Skin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Activation of guinea pig polymorphonuclear leukocytes with soluble stimulators leads to nonrandom distribution of NADPH oxidase in the plasma membrane.
Topics: Animals; Cell Membrane; Guinea Pigs; Hydrolases; Kinetics; Myristic Acid; Myristic Acids; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
Anti-glucocorticoids block the enhancement of mouse mammary tumor virus production by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Binding, Competitive; Carcinogens; Cell Line; Chlorpromazine; Cortodoxone; Desoxycorticosterone; Dexamethasone; Estradiol; Glucocorticoids; Kinetics; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Methyltestosterone; Mice; Mice, Inbred C3H; Phorbols; Progesterone; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate | 1983 |
Triphenyltin chloride inhibits superoxide production by human neutrophils stimulated with a surface active agent.
Topics: Adult; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Organotin Compounds; Phorbols; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
[Effect of the tumor promotor 12-o-tetradecanoyl phorbol-13--acetate on cyclic adenosine monophosphate levels in cell cultures. Relation to cell proliferation].
Topics: Animals; Cell Division; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Drug Resistance; L Cells; Liver Neoplasms, Experimental; Mice; Mutation; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Phorbol ester inhibition of ovarian and testicular steroidogenesis in vitro.
Topics: Animals; Bucladesine; Estrogens; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Granulosa Cells; In Vitro Techniques; Kinetics; Male; Phorbols; Progesterone; Rats; Rats, Inbred Strains; Steroids; Testis; Tetradecanoylphorbol Acetate | 1984 |
Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells.
Topics: Animals; Cyclic AMP; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Phorbol Esters; Phorbols; Phosphorylation; Rats; Ribosomal Protein S6; Ribosomal Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Epstein-Barr virus-specific DNase activity in nonproducer Raji cells after treatment with 12-o-tetradecanoylphorbol-13-acetate and sodium butyrate.
Topics: Antigen-Antibody Complex; Burkitt Lymphoma; Butyrates; Butyric Acid; Cell Line; Deoxyribonucleases; DNA-Directed DNA Polymerase; Herpesvirus 4, Human; Humans; Immune Sera; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Effect of thymosin and phorbol ester on purine metabolic enzymes and cell surface phenotype in a malignant T-cell line (MOLT-3).
Topics: 5'-Nucleotidase; Adenosine Deaminase; Adult; Antigens, Surface; Cell Line; Cell Membrane; DNA Nucleotidylexotransferase; Humans; Mitotic Index; Nucleotidases; Pentosyltransferases; Phenotype; Phorbols; Purines; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymosin | 1983 |
Phosphorylation of myosin light chain in intact pig leukocytes stimulated by phorbol 12-myristate 13-acetate.
Topics: Animals; Calmodulin; Molecular Weight; Myosins; Neutrophils; Phorbols; Phosphorylation; Superoxides; Swine; Tetradecanoylphorbol Acetate | 1984 |
Resistance to 12-0-tetradecanoyl phorbol 13-acetate-induced mitogenesis in the nude mouse.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Lymphocyte Activation; Mice; Mice, Nude; Mitosis; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1984 |
Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.
Topics: Carcinogens; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1984 |
Possible mechanism of phorbol diester-induced maturation of human promyelocytic leukemia cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Differentiation; Cell Line; Enzyme Activation; Humans; Leukemia, Myeloid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1984 |
Retinoic acid-induced changes in epidermal growth factor binding and in biological responses mediated by phorbol ester tumor promoter.
Topics: Animals; Carrier Proteins; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Mice; Ornithine Decarboxylase; Phorbols; Rats; Receptors, Retinoic Acid; Temperature; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Heat durability of Epstein-Barr virus-activating substances of plant origin: 12-O-tetradecanoylphorbol-13-acetate, 12-O-hexadecanoyl-16-hydrophorbol-13-acetate, croton oil, tung oil and Croton megalocarpus extract.
Topics: Antigens, Viral; Cell Line; Herpesvirus 4, Human; Hot Temperature; Humans; Phorbol Esters; Phorbols; Plant Extracts; Soil Pollutants; Tetradecanoylphorbol Acetate; Virus Activation | 1984 |
Calcium ionophore A-23187 and 12-O-tetradecanoyl-phorbol-13-acetate stimulation of prostaglandin synthesis in herpes simplex virus type 2-transformed rat cells.
Topics: Animals; Calcimycin; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dinoprost; Dinoprostone; Embryo, Mammalian; Fibrosarcoma; Kinetics; Neoplasm Metastasis; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Simplexvirus; Tetradecanoylphorbol Acetate | 1984 |
Antagonistic action of retinoic acid against teleocidin and 12-O-tetradecanoyl-phorbol-13-acetate on activation of Epstein-Barr virus genomes.
Topics: Alkaloids; Burkitt Lymphoma; Carcinogens; Cell Line; Cell Survival; DNA Replication; Drug Antagonism; Genes, Viral; Herpesvirus 4, Human; Humans; Lyngbya Toxins; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Virus Replication | 1984 |
Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Biological Transport, Active; Calcium; Cell Membrane; Cytosol; Fluorescent Dyes; Guinea Pigs; Ion Channels; Kinetics; Neutrophils; Phorbols; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes.
Topics: Angiotensin II; Animals; Calcimycin; Epinephrine; Female; In Vitro Techniques; Kinetics; Liver; Liver Glycogen; Phorbols; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Urea; Vasopressins | 1984 |
Inhibition by palmitoylcarnitine of adhesion and morphological changes in HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Caenorhabditis elegans Proteins; Carnitine; Carrier Proteins; Cell Adhesion; Cell Line; Drug Antagonism; Humans; Kinetics; Leukemia, Myeloid, Acute; Palmitoylcarnitine; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Restoration by parathyroid hormone and dibutyryl cyclic AMP of expression of the differentiated phenotype of chondrocytes inhibited by a tumor promoter, 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Bucladesine; Cartilage; Cell Differentiation; Cell Division; Glycosaminoglycans; Male; Parathyroid Hormone; Phenotype; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1983 |
12-O-tetradecanoyl-phorbol-13-acetate-induced ACTH secretion in pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Cells, Cultured; Cyclic AMP; Dexamethasone; Indomethacin; Mice; Phorbols; Phospholipases A; Phospholipases A2; Pituitary Neoplasms; Prostaglandins; Tetradecanoylphorbol Acetate | 1984 |
Protective effect of cAMP on tumor promoter-mediated inhibition of cell-cell communication.
Topics: Aminophylline; Amnion; Bucladesine; Cell Communication; Cell Line; Cell Membrane; Humans; Membrane Potentials; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.
Topics: Animals; Bucladesine; Calcium; Cells, Cultured; Chick Embryo; Dibutyryl Cyclic GMP; Fibroblasts; Kinetics; Mice; Muscle Proteins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphopeptides; Phosphorylation; Tetradecanoylphorbol Acetate; Trypsin; Vinculin | 1984 |
Continuous suppression of globin gene expression and differentiation of Friend erythroleukemia cells by phorbol 12-myristate 13-acetate (PMA) despite the loss of PMA binding sites by down regulation.
Topics: Acetamides; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Differentiation; Cell Line; Clone Cells; Genes; Globins; Kinetics; Leukemia, Experimental; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.
Topics: Adenosine Triphosphate; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Weight; Peptide Fragments; Phorbols; Phosphorus Radioisotopes; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Phosphorylation of specific polypeptides induced by 12-O-tetradecanoylphorbol-13-acetate in chick embryo fibroblasts.
Topics: Animals; Calcimycin; Cells, Cultured; Chick Embryo; Cyclic AMP; Fibroblasts; Kinetics; Molecular Weight; Peptides; Phorbols; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Proteins; Tetradecanoylphorbol Acetate | 1984 |
Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred Strains; Phorbols; Receptors, Cell Surface; Skin; Skin Neoplasms; Skin Physiological Phenomena; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
The phorbol ester, TPA inhibits glucagon-stimulated adenylate cyclase activity.
Topics: Adenylyl Cyclases; Animals; Cholera Toxin; Cyclic AMP; Diglycerides; Glucagon; Guanylyl Imidodiphosphate; Liver; Male; Phorbols; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1984 |
Activation of protein kinase C by a tumor-promoting phorbol ester in pancreatic islets.
Topics: Animals; Calcium; Choline; Diglycerides; Enzyme Activation; Insulin; Insulin Secretion; Islets of Langerhans; Phorbols; Phosphatidylcholines; Phosphatidylinositols; Phosphorus Radioisotopes; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1984 |
Effect of gold compounds on phorbol myristic acetate (PMA) activated superoxide (O2-) production by mouse peritoneal macrophages.
Topics: Animals; Gold; Macrophages; Male; Mice; Mice, Inbred C57BL; Oils; Organogold Compounds; Organometallic Compounds; Peritoneum; Phorbols; Phosphines; Respiration; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line; Clone Cells; Cloning, Molecular; DNA Restriction Enzymes; Epidermal Growth Factor; Genes; Genetic Vectors; Growth Hormone; Humans; Phorbols; Prolactin; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1984 |
Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.
Topics: Biological Transport; Cell Line; Cell Membrane; Humans; Iron; Iron Radioisotopes; Kinetics; Leukemia, Myeloid, Acute; Phorbols; Receptors, Cell Surface; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Transferrin | 1984 |
Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.
Topics: Animals; Blood Platelets; Caenorhabditis elegans Proteins; Calcimycin; Calcium; Carcinogens; Carrier Proteins; Enzyme Activation; Humans; Phorbols; Phospholipids; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, Drug; Serotonin; Tetradecanoylphorbol Acetate | 1984 |
Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Phorbols; Phosphorylation; Receptors, Cell Surface; Succinimides; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.
Topics: Amiloride; Carrier Proteins; Cell Line; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pyrazines; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1984 |
Augmentation of mixed lymphocyte response. Stimulatory activity by phorbol ester.
Topics: 5'-Nucleotidase; Cell Line; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nucleotidases; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Phorbol diester induces expression of Tac antigen on human acute T lymphocytic leukemic cells.
Topics: Antigens, Surface; Binding Sites, Antibody; Cell Line; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1984 |
Induction of mouse brain ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate is independent of TPA receptor concentration.
Topics: Aging; Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Enzyme Induction; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Substrate Specificity; Tetradecanoylphorbol Acetate | 1984 |
Analysis of human promyelocytic leukemia cell (HL60) variants insensitive to phorbol ester tumor promoters.
Topics: Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Genetic Variation; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1984 |
Proliferative response of normal and activated human lymphocytes to tetradecanoyl phorbol acetate.
Topics: Cell Division; Drug Synergism; Humans; Interleukin-2; Lymphocyte Activation; Lymphocytes; Monocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1984 |
Characterization of the response of human thymocytes and blood lymphocytes to the synergistic mitogenicity of 12-O-tetradecanoylphorbol-13-acetate (TPA)-ionomycin.
Topics: Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Ethers; Humans; Ionomycin; Lymphocyte Activation; Mitogens; Phenotype; Phorbols; Receptors, Antigen, B-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Mechanism of phorbol myristate acetate-induced lymphotoxin production by a human T cell hybridoma.
Topics: Cell Line; Humans; Hybridomas; Kinetics; Leukemia, Lymphoid; Lymphotoxin-alpha; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters inhibit murine B cell differentiation to immunoglobulin secretion but not proliferation.
Topics: Animals; Antibody-Producing Cells; B-Lymphocytes; Cell Differentiation; Dose-Response Relationship, Immunologic; Female; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Influence of PMA on T-lymphocyte responses to mitogenic lymphokines.
Topics: Animals; Clone Cells; Female; Interleukin-2; Lectins; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; Spleen; Subcellular Fractions; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1984 |
Comparison of phorbol myristate acetate and phytohaemagglutinin as stimulators of in vitro T lymphocyte colony formation of human peripheral blood lymphocytes. I. Surface markers of colony cells.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Division; Clone Cells; Humans; Lymphocyte Activation; Monocytes; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Cytochemical analysis of acid hydrolases expression during phorbol diester (TPA)-driven differentiation of B-chronic lymphocytic leukaemia cells in vitro.
Topics: Acetylglucosaminidase; Acid Phosphatase; Aged; B-Lymphocytes; Cell Differentiation; Glucuronidase; Humans; Leukemia, Lymphoid; Lysosomes; Naphthol AS D Esterase; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised extracellular magnesium induce proliferation of chicken heart mesenchymal cells.
Topics: Animals; Cell Division; Cells, Cultured; Chickens; Epidermal Growth Factor; Ethers; Heart; Ionomycin; Magnesium; Myocardium; Ouabain; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Induction of maturation in different types of B-cell lymphomas in vitro with TPA and antibodies to surface immunoglobulin.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Differentiation; Flow Cytometry; Humans; Lymphoma; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1984 |
Phorbol myristate acetate-stimulated production of interleukin 2 by T-cell lymphoma and constitutive production by derived hybridomas.
Topics: Animals; Cell Division; Cell Line; Humans; Hybridomas; Interleukin-2; Lymphoma; Phorbols; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Ca2+-dependent and phorbol ester activating phosphorylation of a 36K-dalton protein of rat basophilic leukemia cell membranes and immunoprecipitation of the phosphorylated protein with IgE-anti IgE system.
Topics: Amino Acids; Animals; Antibodies, Anti-Idiotypic; Basophils; Calcium; Enzyme Activation; Immunoglobulin E; Leukemia; Molecular Weight; Neoplasm Proteins; Phorbols; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1984 |
Interleukin 2-dependent T cell line acquires responsiveness to phorbol myristate acetate and lipopolysaccharide in the course of long-term culture.
Topics: Animals; Cell Line; Clone Cells; Interleukin-2; Kinetics; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Phorbols; Receptors, Drug; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Transcriptional modulation of human T-cell growth factor gene by phorbol ester and interleukin 1.
Topics: Cells, Cultured; Dactinomycin; Genes; Humans; Interleukin-1; Interleukin-2; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Synergistic effect of TPA and T-cell mitogens in nonmammalian vertebrates.
Topics: Amphibians; Animals; Birds; Cells, Cultured; Chromosomes; Concanavalin A; Drug Synergism; Female; Fishes; Lymphocyte Activation; Male; Metaphase; Mitogens; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Interaction of tumour-promoting agents with immunofunctional cells in vitro and in vivo.
Topics: Animals; DNA Replication; Enterotoxins; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Phorbols; Phytohemagglutinins; Species Specificity; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Phorbol myristate acetate induced colony growth in Hodgkin's disease.
Topics: Cell Division; Cells, Cultured; Cytological Techniques; Hodgkin Disease; Humans; Lymph Nodes; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Human T-cell hybridomas producing lymphokines. II. Enhancement of lymphotoxin secretion from human T-cell hybridomas by phorbol myristate acetate.
Topics: Clone Cells; Concanavalin A; Dose-Response Relationship, Immunologic; Humans; Hybridomas; Kinetics; Lymphotoxin-alpha; Macrophage Migration-Inhibitory Factors; Phenotype; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Effects of phorbol 12-myristate 13-acetate on the differentiation program of embryonic chick skeletal myoblasts.
Topics: Animals; Cell Cycle; Cell Differentiation; Chick Embryo; Desmin; DNA Replication; Intermediate Filament Proteins; Muscles; Myosin Subfragments; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
[Tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a protein in human lymphocytes binding satellite DNA].
Topics: Bacteriophages; Blood Proteins; Carcinogens; Cells, Cultured; Chromosomes, Human; Cloning, Molecular; DNA, Satellite; Escherichia coli; Humans; Lymphocytes; Mitosis; Phorbols; Plasmids; Protein Binding; Tetradecanoylphorbol Acetate | 1983 |
Effects of dexamethasone and phorbol myristate acetate on the induction of differentiation in mouse erythroleukemic cells by dimethyl sulfoxide, proteases, and other compounds.
Topics: Animals; Cell Differentiation; Cell Division; Dactinomycin; Dexamethasone; Dimethyl Sulfoxide; Leukemia, Erythroblastic, Acute; Mice; Peptide Hydrolases; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.
Topics: Animals; Arginine Vasopressin; Carcinogens; Cells, Cultured; Clone Cells; Drug Resistance; Epidermal Growth Factor; Gene Amplification; Genes; Hormones; Insulin; Methotrexate; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1983 |
Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release.
Topics: Animals; Calcium; Drug Synergism; Gliclazide; Glucose; Insulin; Islets of Langerhans; Phorbols; Rats; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
TPA induces simultaneous alterations in the synthesis and organization of vimentin.
Topics: Animals; Cells, Cultured; Chick Embryo; Cytoskeleton; Dactinomycin; Fluorescent Antibody Technique; Intermediate Filament Proteins; Kinetics; Microtubules; Phorbols; Tetradecanoylphorbol Acetate; Vimentin | 1983 |
Phorbol ester-induced adhesion of murine erythroleukemia cells: possible involvement of cellular proteases.
Topics: Animals; Cell Adhesion; Cell Line; Kinetics; Leukemia, Experimental; Mice; Peptide Hydrolases; Phorbols; Tetradecanoylphorbol Acetate; Trypsin Inhibitors | 1983 |
Phorbol myristate acetate stimulated NBT test: a simple method suitable for antenatal diagnosis of chronic granulomatous disease.
Topics: Adolescent; Adult; Child; Child, Preschool; Endotoxins; Escherichia coli; Female; Genetic Carrier Screening; Granulomatous Disease, Chronic; Humans; Infant; Male; Nitroblue Tetrazolium; Phorbols; Pregnancy; Prenatal Diagnosis; Tetradecanoylphorbol Acetate; Tetrazolium Salts | 1983 |
Changes in the expression of B cell surface markers on complement receptor-positive and complement receptor-negative B cells induced by phorbol myristate acetate.
Topics: Animals; B-Lymphocytes; Cell Separation; Female; Flow Cytometry; Histocompatibility Antigens Class II; Interphase; Lymphocyte Activation; Macrophage-1 Antigen; Male; Mice; Mice, Inbred A; Mice, Inbred CBA; Phorbols; Receptors, Antigen, B-Cell; Receptors, Complement; Tetradecanoylphorbol Acetate | 1984 |
Increased sensitivity of mouse mammary gland for hormones and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate in tissues containing the Mtv-2 gene.
Topics: Animals; Culture Techniques; Female; Genes; Insulin; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Phorbols; Progesterone; Prolactin; Tetradecanoylphorbol Acetate; Thymidine | 1984 |
Modulation of cell surface antigens induced by 12-O-tetradecanoyl-phorbol 13-acetate in two myeloblastic cell lines, a promyelocytic cell line, and a monoblastic cell line: detection with five monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Adhesion; Cell Line; Cell Membrane; Fluorescent Antibody Technique; Humans; Kinetics; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Macrophages; Monocytes; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Comparison of M-line and other myofibril components during reversible phorbol ester treatment.
Topics: Animals; Avian Proteins; Chick Embryo; Connectin; Fluorescent Antibody Technique; Muscle Proteins; Muscles; Myofibrils; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Monoclonal antibody MCS-2 as the marker of phorbol diester-induced myeloid differentiation in acute undifferentiated leukemia.
Topics: Acute Disease; Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Cells, Cultured; Fluorescent Antibody Technique; Humans; Leukemia; Leukocytes; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester-induced differentiation of a non-T/non-B human leukemic cell line (REH) to macrophage-like cells.
Topics: Cell Differentiation; Cell Line; Fluorescent Antibody Technique; Humans; Leukemia; Lymphocytes; Macrophages; Muramidase; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of phorbol-ester-induced adhesion of differentiating human myeloid leukemic cells by pentamidine-isethionate.
Topics: Amidines; Cell Adhesion; Cell Differentiation; Cell Line; Humans; Leukemia, Myeloid; Pentamidine; Peptide Hydrolases; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1984 |
Transcriptional induction of urokinase in cultured human kidney carcinoma cells by tetradecanoyl-phorbol-acetate.
Topics: Cell Line; Enzyme Induction; Fluorescent Antibody Technique; Humans; Kidney Neoplasms; Kinetics; Molecular Weight; Nucleic Acid Hybridization; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urokinase-Type Plasminogen Activator | 1984 |
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.
Topics: Animals; Insulin; Kinetics; Liver Neoplasms, Experimental; Macromolecular Substances; Molecular Weight; Phorbols; Phosphorylation; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1984 |
Enhanced arachidonic acid lipoxygenation by K562 cells stimulated with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Arachidonate Lipoxygenases; Humans; Leukemia, Myeloid; Lipoxygenase; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Tachyphylaxis in 12-0-tetradecanoylphorbol acetate- and arachidonic acid-induced ear edema.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ear; Edema; Female; Kinetics; Mice; Phorbols; Tachyphylaxis; Tetradecanoylphorbol Acetate; Vasodilation | 1983 |
Ribosomal RNA synthesis and growth in mouse epidermis following initiation with dimethylbenzanthracene and promotion with 12-0-tetradecanoyl-phorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cell Division; Female; Kinetics; Mice; Organ Size; Phorbols; RNA, Ribosomal; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1983 |
Stimulation of human chorionic gonadotropin and progesterone secretion by tumor promoters, phorbol ester and teleocidin B, in cultured choriocarcinoma cells.
Topics: Alkaloids; Animals; Carcinogens; Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Epidermal Growth Factor; Female; Humans; Kinetics; Lyngbya Toxins; Male; Mice; Phorbols; Pregnancy; Progesterone; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 1983 |
12-O-tetradecanoylphorbol-13-acetate stimulates release of arachidonic acid, prostaglandin E2 and prostaglandin F2 alpha from TPA nonproliferative variants of 3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Line; Dinoprost; Dinoprostone; Fibroblasts; Mice; Phorbols; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1983 |
Induction of plasminogen activator by 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore. Suppression by inhibitors of fatty acid lipoxygenase.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Calcimycin; Catechols; Cells, Cultured; Enzyme Induction; Fatty Acids; HeLa Cells; Humans; Hydroxyeicosatetraenoic Acids; Leukemia, Experimental; Lipoxygenase Inhibitors; Masoprocol; Phorbols; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1983 |
Effect of the promoter 12-O-tetradecanoylphorbol-13-acetate on the evolution of carcinogen-altered cell populations in tracheas initiated with 7,12-dimethylbenz(a)anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cell Division; Female; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Tracheal Neoplasms | 1983 |
Nature of the epidermal hyperplasia produced by mezerein, a weak tumor promoter, in initiated skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Enhanced expression of human Ia antigens by chronic lymphocytic leukemia cells following treatment with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Antibodies, Monoclonal; Cells, Cultured; Gene Expression Regulation; Genes, MHC Class II; Humans; Leukemia, Lymphoid; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Phorbol myristate acetate-induced macrophage aggregation.
Topics: Animals; Calcimycin; Calcium; Cell Aggregation; Guinea Pigs; Macrophages; Magnesium; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Phorbol myristate acetate and in vitro T lymphocyte function. I. PMA may contaminate lymphokine preparations and can interfere with interleukin bioassays.
Topics: Animals; Drug Contamination; Female; Interleukin-1; Interleukin-2; Interleukin-3; Leukemia P388; Lymphocyte Activation; Lymphokines; Macrophages; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Glycosyltransferase activities and the differentiation of human promyelocytic (HL60) cells by retinoic acid and a phorbol ester.
Topics: Cell Differentiation; Cell Line; Fucosyltransferases; Galactosyltransferases; Hexosyltransferases; Humans; Kinetics; Leukemia, Myeloid, Acute; Neuraminidase; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1983 |
Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Carboxy-Lyases; Cell Membrane; Cells, Cultured; Embryo, Mammalian; Female; Histidine Decarboxylase; Kinetics; Membrane Lipids; Mice; Phorbols; Phospholipids; Pregnancy; Rats; Salicylates; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Synergistic functions of phorbol ester and calcium in serotonin release from human platelets.
Topics: Blood Platelets; Calcimycin; Calcium; Drug Synergism; Humans; In Vitro Techniques; Phorbol Esters; Phorbols; Phosphorylation; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1983 |
Calcium-dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter.
Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Cattle; Concanavalin A; DNA; Egtazic Acid; Lymphocyte Activation; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Stimulation of deacylation in Madin-Darby canine kidney cells. 12-O-tetradecanoyl-phorbol-13-acetate stimulates rapid phospholipid deacylation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Dogs; Indomethacin; Kidney; Kinetics; Phorbols; Phospholipids; Prostaglandins; Tetradecanoylphorbol Acetate | 1983 |
Stimulation of growth of human melanocytes by tumor promoters.
Topics: Alkaloids; Cell Division; Cell Line; Cholera Toxin; Diterpenes; Humans; Lyngbya Toxins; Male; Melanocytes; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Phorbol diesters stimulate somatostatin secretion from cultured brain cells.
Topics: Alkaloids; Animals; Cell Line; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Hypothalamus; Lyngbya Toxins; Peptides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate; Verapamil | 1983 |
Induction of sister-chromatid exchanges by DNA-damaging agents and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in synchronous Chinese hamster ovary (CHO) cells.
Topics: Animals; Cell Cycle; Clone Cells; Cricetinae; Cricetulus; Crossing Over, Genetic; DNA; Female; Mitomycin; Mitomycins; Ovary; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1983 |
Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium.
Topics: Animals; Calcium; Cell Aggregation; Chemotaxis, Leukocyte; Edetic Acid; Magnesium; Neutrophils; Oxygen Consumption; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1983 |
Mechanism of action of phorbol myristate acetate on human natural killer cell activity.
Topics: Calcimycin; Cell Adhesion; Cell Line; Cytochalasins; Cytotoxicity, Immunologic; Humans; Killer Cells, Natural; Kinetics; Leukemia, Myeloid, Acute; Mycotoxins; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Multiple lymphokine production by a phorbol ester-stimulated mouse thymoma: relationship to cell cycle events.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Cycle; Flow Cytometry; Interferon-gamma; Lymphokines; Mice; Neoplasms, Experimental; Phenotype; Phorbols; Rats; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms | 1983 |
Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Cattle; Cyclooxygenase Inhibitors; Enzyme Activation; Kinetics; Lipoxygenase; Lipoxygenase Inhibitors; Lymphocyte Activation; Lymphocytes; Masoprocol; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Topics: Animals; DNA; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
A tumor promoter stimulates phosphorylation on tyrosine.
Topics: Animals; Chick Embryo; Fibroblasts; Molecular Weight; Phorbols; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1983 |
The effect of the tumor promoter, phorbol myristate acetate (PMA), on hyaluronic acid (HA) synthesis by chicken embryo fibroblasts.
Topics: Animals; Cells, Cultured; Chick Embryo; Fibroblasts; Glucuronosyltransferase; Glycosyltransferases; Hyaluronan Synthases; Hyaluronic Acid; Hyaluronoglucosaminidase; Kinetics; Membrane Proteins; Phorbols; Tetradecanoylphorbol Acetate; Transferases; Xenopus Proteins | 1983 |
Modification of glycogen synthase activity in isolated rat hepatocytes by tumor-promoting phorbol esters: evidence for differential regulation of glycogen synthase and phosphorylase.
Topics: Animals; Glycogen Synthase; In Vitro Techniques; Kinetics; Liver; Male; Phorbol Esters; Phorbols; Phosphorylases; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Aldosterone secretion: effect of phorbol ester and A23187.
Topics: Adrenal Medulla; Aldosterone; Angiotensin II; Animals; Calcimycin; Calcium; Phorbols; Swine; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Ca2+-dependent stimulation of hexose transport by A23187, 12-O-tetradecanoylphorbol-13-acetate and epidermal growth factor in mouse fibroblasts.
Topics: Animals; Biological Transport, Active; Calcimycin; Calcium; Deoxy Sugars; Deoxyglucose; Egtazic Acid; Epidermal Growth Factor; Fibroblasts; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Regulation of arachidonic acid metabolism in Madin-Darby canine kidney cells. Comparison of A23187 and 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cycloheximide; Dinoprostone; Dogs; Kidney; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate | 1984 |
Effects of the skin mitogens tumor-promotor 12-O-tetradecanoylphorbol 13-acetate and divalent-cation-ionophore A23187 on ion fluxes and membrane potential in a murine epidermal cell line (HEL30) and in 3T3 fibroblasts.
Topics: Animals; Arachidonic Acids; Biological Transport; Calcimycin; Cations, Divalent; Cell Division; Cell Line; Epidermis; Fibroblasts; Hyperplasia; Membrane Potentials; Mice; Mitogens; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Acute effects of 12-O-tetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin on cultured normal human bronchial epithelial cells.
Topics: Alkaloids; Bronchi; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Dioxins; DNA Replication; Epithelium; Humans; Kinetics; Lyngbya Toxins; Phorbols; Polychlorinated Dibenzodioxins; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Synergistic activation of rat hepatocyte glycogen phosphorylase by A23187 and phorbol ester.
Topics: Animals; Calcimycin; Drug Synergism; Enzyme Activation; Female; Kinetics; Liver; Phorbols; Phosphorylases; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 1984 |
Inhibition by 1 alpha, 25-dihydroxyvitamin D3 of induction of epidermal ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate and teleocidin B.
Topics: Alkaloids; Animals; Calcitriol; Drug Antagonism; Enzyme Induction; Female; Kinetics; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
A model for human colon carcinoma evolution based on the differential response of cultured preneoplastic, premalignant, and malignant cells to 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenoma; Adult; Aged; Alkaloids; Carcinogens; Cells, Cultured; Colon; Colonic Neoplasms; Female; Humans; Intestinal Polyps; Lyngbya Toxins; Male; Middle Aged; Models, Biological; Phorbols; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1984 |
Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cricetinae; Drug Synergism; Female; Male; Neoplasms; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Three molecular weight forms of natural human interferon-gamma revealed by immunoprecipitation with monoclonal antibody.
Topics: Antibodies, Monoclonal; Cells, Cultured; Humans; Interferon-gamma; Lymphocyte Activation; Lymphocytes; Molecular Weight; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1984 |
Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin.
Topics: Amino Acids; Animals; Epidermis; Female; Filaggrin Proteins; Fluorescent Antibody Technique; Immunodiffusion; Intermediate Filament Proteins; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Alterations in enzyme expression on 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of chronic lymphocytic leukemia cells.
Topics: Adenosine Deaminase; B-Lymphocytes; Cell Differentiation; DNA-Directed DNA Polymerase; Humans; Immunoglobulin M; In Vitro Techniques; Leukemia, Lymphoid; Phorbols; Purine-Nucleoside Phosphorylase; Tetradecanoylphorbol Acetate; Thymidine Phosphorylase | 1984 |
Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.
Topics: Animals; Antioxidants; Enzyme Induction; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Cyclooxygenase inhibition during phorbol-induced granulocyte stimulation in awake sheep.
Topics: Animals; Consciousness; Cyclooxygenase Inhibitors; Granulocytes; Hypertension, Pulmonary; Hypoxia; Inflammation; Lung Diseases; Lymph; Meclofenamic Acid; Phorbols; Sheep; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1984 |
Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.
Topics: Animals; Blood Proteins; Calcimycin; Carcinogens; Cytochalasin B; Kinetics; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol Esters; Phorbols; Phosphorylation; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate; Trifluoperazine | 1984 |
Mitogenic and comitogenic properties of the indole alkaloid class of tumor promotors.
Topics: Alkaloids; Animals; Carcinogens; Drug Synergism; Humans; In Vitro Techniques; Interleukin-2; Lectins; Lymphocytes; Lyngbya Toxins; Mice; Mitosis; Monocytes; Peanut Agglutinin; Phorbols; Tetradecanoylphorbol Acetate; Thymidine; Thymus Gland | 1984 |
TPA-induced contraction of isolated rabbit vascular smooth muscle.
Topics: Animals; Arteries; Calcimycin; Calcium; Colforsin; Diterpenes; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phorbols; Phosphorylation; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate | 1984 |
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kinetics; Leukemia, Myeloid, Acute; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Spermidine; Tetradecanoylphorbol Acetate | 1984 |
Effects of 12-0-tetradecanoyl-phorbol-13-acetate on oral epithelium in vitro.
Topics: Animals; Cell Division; Cricetinae; Culture Techniques; Epithelial Cells; Epithelium; Male; Mesocricetus; Microscopy, Electron; Mitotic Index; Mouth Mucosa; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Effect of calmidazolium and phorbol ester on catecholamine secretion from adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Kinetics; Phorbols; Potassium; Tetradecanoylphorbol Acetate | 1984 |
A phorbol ester and A23187 act synergistically to release acetylcholine from the guinea pig ileum.
Topics: Acetylcholine; Animals; Calcimycin; Calcium; Choline; Drug Synergism; Electric Stimulation; Female; Guinea Pigs; Ileum; Kinetics; Male; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1984 |
Influence of a tumor-promoting phorbol ester on the electrical response of B-cells to glucose and glyburide.
Topics: Animals; Electric Conductivity; Evoked Potentials; Glucose; Glyburide; Islets of Langerhans; Male; Membrane Potentials; Mice; Mice, Inbred CBA; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; DNA Replication; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA; Female; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
A comparison of the effects of tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin on gene expression in human skin cell fibroblasts.
Topics: Autoradiography; Carcinogens; Cell Differentiation; Child; Epidermal Growth Factor; Female; Fibroblasts; Gene Expression Regulation; Humans; Lyngbya Toxins; Male; Middle Aged; Phorbols; Protein Biosynthesis; Skin; Tetradecanoylphorbol Acetate | 1984 |
The induction of Leu-1 antigen expression in human malignant and normal B cells by phorbol myristic acetate (PMA).
Topics: Antigens, Differentiation, B-Lymphocyte; Antigens, Differentiation, T-Lymphocyte; Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Humans; Immunoglobulins; Leukemia; Lymphocyte Activation; Lymphoma; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
The effect of 12-O-tetradecanoylphorbol-13-acetate and other tumor promoters on the colony formation of rat tracheal epithelial cells in culture.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; Epithelial Cells; Epithelium; Lyngbya Toxins; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred F344; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Trachea | 1984 |
Phorbol esters as probes of the regulation of thyrotropin secretion.
Topics: Animals; Calcimycin; Cycloheximide; Dose-Response Relationship, Drug; Male; Phorbol Esters; Phorbols; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1984 |
Induction of IL-2 production, IL-2 receptor expression and proliferation of T3- T-PLL cells by phorbol ester.
Topics: Antigens, Neoplasm; Cell Division; Cells, Cultured; Humans; Interleukin-2; Leukemia, Lymphoid; Phenotype; Phorbols; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Membrane-mediated responses to 12-O-tetradecanoylphorbol-13-acetate in human skin fibroblasts.
Topics: Carcinogens; Cell Membrane; Cells, Cultured; Child; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Female; Fetus; Fibroblasts; Humans; Kinetics; Lyngbya Toxins; Male; Membrane Proteins; Middle Aged; Molecular Weight; Peptide Fragments; Phorbols; Pregnancy; Skin; Tetradecanoylphorbol Acetate | 1984 |
Interaction of phorbol derivatives with replicating cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Cell Cycle; Cell Division; HeLa Cells; Humans; Hydroxyurea; Kinetics; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Enhancement of primate retrovirus synthesis by tumour promoters.
Topics: Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA Replication; Female; Humans; Kidney; Leukemia, Lymphoid; Lyngbya Toxins; Ovarian Neoplasms; Phorbols; Retroviridae; Rhabdomyosarcoma; Species Specificity; Tetradecanoylphorbol Acetate; Virus Replication | 1984 |
EGF growth promoting activity is neutralized by phorbol esters.
Topics: Cell Division; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Inhibitors; Humans; Insulin; Mitogens; Peptides; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
12-O-tetradecanoyl-phorbol-13-acetate release of glycosyltransferases from human blood cells.
Topics: Cell Separation; Concanavalin A; Ficoll; Glucosyltransferases; Granulocytes; Humans; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Inhibitory effect of tumor promoting phorbol esters and mezerein on human mixed lymphocyte reaction.
Topics: Antineoplastic Agents, Phytogenic; Diterpenes; DNA; Humans; Lymphocyte Culture Test, Mixed; Lymphocytes; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1981 |
[The effect of 12-O-tetradecanoylphorbol-13-acetate on acute myeloid leukemia cells obtained directly from the patient. Failure of the compound to induce a "true" maturation].
Topics: Cells, Cultured; Humans; Leukemia, Myeloid, Acute; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: induction of competence or incomplete removal?
Topics: Animals; Blood Platelets; Cell Cycle; Cell Division; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; Insulin; Mice; Mitogens; Peptides; Phorbols; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Modulation of chronic lymphocytic leukemia cells by phorbol ester: increase in Ia expression, IgM secretion and MLR stimulatory capacity.
Topics: Aged; Animals; Binding Sites, Antibody; Cell Transformation, Neoplastic; Dose-Response Relationship, Immunologic; Female; Histocompatibility Antigens Class II; Humans; Immunoglobulin M; Leukemia, Lymphoid; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred A; Phorbols; Rabbits; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1982 |
In vitro modulation of oncogenesis and differentiation by retinoids and tumor promoters.
Topics: Adenosine Triphosphatases; Animals; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Cricetinae; Embryo, Mammalian; Mice; Phorbols; Retinol-Binding Proteins; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Tretinoin; X-Rays | 1982 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on lymphocyte proliferation.
Topics: Animals; Cattle; DNA; Drug Synergism; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Phorbols; Phytohemagglutinins; Spleen; Tetradecanoylphorbol Acetate | 1982 |
Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on neurite outgrowth from chick embryo sensory ganglia.
Topics: Animals; Axons; Chick Embryo; Cytarabine; Ganglia, Spinal; Kinetics; Nerve Growth Factors; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation.
Topics: Cell Differentiation; Cell Division; Cell Line; Humans; Neuroblastoma; Neurons; Norepinephrine; Phenotype; Phorbols; Phosphopyruvate Hydratase; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Chemotactic peptide enhancement of PMA triggered monocyte cytotoxicity.
Topics: Cytotoxicity, Immunologic; Drug Synergism; Humans; Male; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Role of interstitium in clearance of alveolar fluid in normal and injured lungs.
Topics: Absorption; Animals; Azo Compounds; Capillary Permeability; Cell Membrane Permeability; Evans Blue; Extracellular Space; Hemodynamics; Isotonic Solutions; Lung; Lymphatic System; Phorbols; Pulmonary Alveoli; Pulmonary Edema; Ringer's Lactate; Sheep; Solutions; Tetradecanoylphorbol Acetate | 1984 |
Chronic application of a tumor promoter to confluent nontransformed rat cells induces the irreversible expression of transformed phenotype.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Female; Phenotype; Phorbols; Pregnancy; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
The transformation of a rat cell line induced by a tumor promoter occurs without affecting sister chromatid exchange.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Crossing Over, Genetic; Female; Phenotype; Phorbols; Pregnancy; Rats; Rats, Inbred F344; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate | 1984 |
Selective loss of the expression of OKT-4 or Leu-3A defined antigen by 12-0-tetradecanoylphorbol-13-acetate (TPA) in human lymphoid cells.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cattle; Cell Line; Humans; Lymphoid Tissue; Phorbols; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-stimulated 3-O-methyl-glucose transport in mouse Swiss 3T3 fibroblasts by glycyrrhetic acid.
Topics: 3-O-Methylglucose; Animals; Antiviral Agents; Biological Transport, Active; Cells, Cultured; Embryo, Mammalian; Glycyrrhetinic Acid; Glycyrrhizic Acid; Kinetics; Methylglucosides; Methylglycosides; Mice; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1984 |
Susceptibility of skin fibroblasts from individuals genetically predisposed to cancer, to transformation by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adult; Animals; Cell Division; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Child; Child, Preschool; Colonic Polyps; Eye Neoplasms; Female; Fetus; Fibroblasts; Humans; Infant; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Phorbols; Pregnancy; Retinoblastoma; Skin; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1984 |
Tumor promoters stimulate hyperplasia of microtubule organizing center and inhibit DNA synthesis in cultured cells.
Topics: DNA; Growth Inhibitors; HeLa Cells; Humans; Hyperplasia; Kinetics; Lyngbya Toxins; Melanoma; Microtubules; Mitotic Index; Organoids; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Enhanced induction of the anchorage-independent phenotype in initiated rat tracheal epithelial cell cultures by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Adhesion; Cell Division; Cells, Cultured; Epithelial Cells; Epithelium; Kinetics; Methylnitronitrosoguanidine; Phenotype; Phorbols; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Trachea | 1984 |
Differential effects of 12-O-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic human bronchial epithelial cells.
Topics: Cell Division; Cell Line; Cell Survival; Cells, Cultured; Clone Cells; Epithelial Cells; Epithelium; Humans; Kinetics; Lung; Lung Neoplasms; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Keratinocyte damage produced by 12-O-tetradecanoylphorbol-13-acetate in rodent epidermis.
Topics: Animals; Epidermis; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Hyperplasia; Mice; Mice, Inbred Strains; NADPH Dehydrogenase; Phorbols; Tetradecanoylphorbol Acetate; Trypan Blue | 1984 |
A mutagenesis-enhancing activity of 12-O-tetradecanoylphorbol 13-acetate detected in Chinese hamster ovary cells.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Synergism; Ethyl Methanesulfonate; Female; Methylnitronitrosoguanidine; Mutation; Ovary; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on carcinogenesis in the heterotopically transplanted rat urinary bladder.
Topics: Animals; Cell Division; Male; Methylnitrosourea; Phorbols; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Urinary Bladder; Urinary Bladder Neoplasms | 1984 |
Enhancement by phorbol esters of cell growth inhibiting action of interferon.
Topics: 2',5'-Oligoadenylate Synthetase; Cell Division; Cell Line; Cell Transformation, Viral; Drug Resistance; Drug Synergism; Humans; Interferon Type I; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
The effect of tetradecanoyl-12, 13-phorbol acetate on 'hairy' cells.
Topics: Cells, Cultured; Cytochalasin D; Cytochalasins; Drug Interactions; Humans; Leukemia, Hairy Cell; Phagocytosis; Phorbols; Photography; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1984 |
Effect of phorbol ester tumor promoters on hairy cell leukemic cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Adhesion; Cell Membrane; Cells, Cultured; Humans; Kinetics; Leukemia, Hairy Cell; Phorbol Esters; Phorbols; Phospholipids; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1984 |
Effects of agents known to antagonize the enhancement of in vitro transformation by 12-tetradecanoyl-phorbol-13-acetate (TPA) on the TPA suppression of metabolic cooperation.
Topics: Animals; Antipain; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Oligopeptides; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tretinoin; Trypsin Inhibitors | 1984 |
Phorbol esters stimulate spermidine/spermine N1-acetyltransferase activity in mitogen-stimulated bovine lymphocytes.
Topics: Acetyltransferases; Animals; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Drug Synergism; Enzyme Activation; Kinetics; Lymphocytes; Phorbol Esters; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1984 |
Transcriptional regulation of a tumor promoter and mitogen-inducible gene in human lymphocytes.
Topics: Cells, Cultured; Gene Expression Regulation; Genes; Humans; Leukemia; Lymphocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Oxidised glutathione reductase activity in mouse epidermis: TPA induced change and its modulation by vitamin A.
Topics: Animals; Epidermis; Female; Glutathione Reductase; Mice; Models, Biological; NADP; Phorbols; Tetradecanoylphorbol Acetate; Vitamin A | 1984 |
Platelet factor 3 availability induced by phorbol-12-myristate-13-acetate.
Topics: Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Cell Membrane; Humans; Phorbols; Platelet Factor 3; Tetradecanoylphorbol Acetate | 1984 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on cell-surface glycosaminoglycans in human diploid fibroblasts.
Topics: Chromatography, Ion Exchange; Diploidy; Fibroblasts; Glycosaminoglycans; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
The effect of promoters on 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Female; Hyperplasia; Intestinal Mucosa; Male; Metaphase; Methylhydrazines; Mice; Mice, Inbred C57BL; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Vincristine | 1984 |
Specific lipid components in membrane receptors of 12-O-tetradecanoylphorbol-13-acetate as revealed by direct photoaffinity labelling.
Topics: Affinity Labels; Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Membrane; Kinetics; Membrane Lipids; Mice; Phorbols; Phospholipids; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1984 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on selection of drug-resistant phenotypes in rodent cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cadmium; Cell Line; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; Drug Resistance; Lung; Methotrexate; Mice; Phenotype; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1984 |
Mechanism of the stimulatory effect of phorbol 12-myristate 13-acetate on cellular production of plasminogen activator.
Topics: Cell Line; Cell Survival; Gene Expression Regulation; Humans; Kinetics; Melanoma; Phorbols; Plasminogen Activators; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Viral; Enzyme Precursors; Female; Fibroblasts; Gene Expression Regulation; Mice; Oocytes; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator; Xenopus laevis | 1984 |
Growth of malignant histiocytic cells induced by phorbol myristate acetate.
Topics: Adult; Cells, Cultured; Histiocytes; Humans; Lymphatic Diseases; Male; Microscopy, Electron; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1984 |
Action of retinoids on the anchorage-independent growth of normal rat kidney fibroblasts induced by 12-O-tetradecanoylphorbol-13-acetate or sarcoma growth factor.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Fibroblasts; Kidney; Peptides; Phorbols; Rats; Retinol-Binding Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tretinoin | 1983 |
The effects of dexamethasone and tetradecanoyl phorbol acetate on plasminogen activator release by human acute myeloid leukemia cells.
Topics: Cell Survival; Cells, Cultured; Dexamethasone; DNA; Granulocytes; Humans; Leukemia, Myeloid, Acute; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1983 |
Essential function deficiency as the result of tumor promotion and the establishment of biological autarchy.
Topics: Cocarcinogenesis; Disease Susceptibility; Humans; Neoplasms; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Vitamin A; Vitamin A Deficiency | 1983 |
The effect of glutathione on HL-60 treated with dimethylsulfoxide, butyric acid or 12-O-tetradecanoylphorbol-13-acetate.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Dimethyl Sulfoxide; Glutathione; Humans; Leukemia, Myeloid, Acute; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Presence of specific binding sites for phorbol ester tumor promoters in human epidermal and dermal cells in culture but lack of down regulation in epidermal cells.
Topics: Binding Sites; Binding, Competitive; Cells, Cultured; Diterpenes; Epidermis; Humans; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester inhibits furosemide-sensitive potassium transport in BALB/c 3T3 preadipose cells.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Cells, Cultured; Furosemide; Kinetics; Mice; Mice, Inbred BALB C; Phorbols; Potassium; Rubidium; Tetradecanoylphorbol Acetate | 1983 |
Control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1,25-dihydroxyvitamin D3 and phorbol-12-myristate-13-acetate.
Topics: Antibodies, Monoclonal; Calcitriol; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Humans; Leukemia, Myeloid, Acute; Macrophages; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis.
Topics: Cell Differentiation; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Myeloid, Acute; Molecular Weight; Phorbols; Phosphorylation; Proteins; Tetradecanoylphorbol Acetate | 1983 |
Generation of procoagulant activity (PCA) by macrophage-like cells derived from acute and chronic myeloid leukaemia cells in response to phorbol esters.
Topics: Adolescent; Adult; Aged; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Cell Differentiation; Cell Separation; Cells, Cultured; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Macrophages; Middle Aged; Monocytes; Phorbols; Reference Values; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester-associated changes in ganglioside metabolism.
Topics: Animals; Carcinogens; Cell Division; Cell Line; Contact Inhibition; Cricetinae; Gangliosides; Palmitic Acid; Palmitic Acids; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Sialic Acids; Sialyltransferases; Tetradecanoylphorbol Acetate | 1983 |
Acetate utilization and fatty acid metabolism in phorbol ester and dimethyl sulfoxide-differentiated human leukemia cells.
Topics: Acetates; Cell Differentiation; Cells, Cultured; Dimethyl Sulfoxide; Fatty Acids; Granulocytes; Humans; Leukemia, Myeloid, Acute; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
[Differentiation induction of acute leukemia cells and its clinical usefulness].
Topics: Adolescent; Adult; Aged; Cell Differentiation; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Double minute chromatin bodies and other chromosome alterations in human myeloid HL-60 leukemia cells susceptible or resistant to induction of differentiation by phorbol-12-myristate-13-acetate.
Topics: Cell Differentiation; Cell Line; Chromatin; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Drug Resistance; Humans; Karyotyping; Leukemia, Myeloid, Acute; Muramidase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Nonspecific esterases of leukemia cell lines: evidence for activation of myeloid-associated zymogens in HL-60 by phorbol esters.
Topics: Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Enzyme Precursors; Esterases; Humans; Isoenzymes; Leukemia, Myeloid; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Response of non-T, non-B acute lymphocytic leukemia cells to phorbol ester.
Topics: Cells, Cultured; Child; Child, Preschool; DNA Replication; Drug Evaluation, Preclinical; Female; Humans; Kinetics; Leukemia, Lymphoid; Lymphocytes, Null; Male; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Rapid phosphorylation-dephosphorylation of specific proteins induced by phorbol ester in HL-60 cells. Further characterization of the phosphorylation of 17-kilodalton and 27-kilodalton proteins in myeloid leukemic cells and human monocytes.
Topics: Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Leukemia, Myeloid, Acute; Molecular Weight; Monocytes; Neoplasm Proteins; Phorbols; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Tetradecanoylphorbol Acetate | 1984 |
Studies of the differentiation of promyelocytic cells by phorbol ester. I. Induction of discrete membrane proteins characteristic of monocytes and expression of motility functions in HL-60 cells following differentiation by phorbol ester.
Topics: Cell Differentiation; Cell Line; Cell Movement; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Leukemia, Myeloid, Acute; Lymphocytes; Macrophages; Membrane Proteins; Molecular Weight; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Studies of the differentiation of promyelocytic cells by phorbol ester. II. A methylation inhibitor, 3-deazaadenosine, inhibits the induction of specific differentiation proteins. Lack of effect on early and late phosphorylation events.
Topics: Cell Adhesion; Cell Differentiation; Cell Line; Cell Movement; Electrophoresis, Polyacrylamide Gel; Humans; Isomerism; Kinetics; Leukemia, Myeloid, Acute; Membrane Proteins; Molecular Weight; Phorbols; Phosphorylation; Ribonucleosides; Tetradecanoylphorbol Acetate; Tubercidin | 1984 |
Glycosaminoglycan synthesis during differentiation of HL60/HGPRT-leukemia cells induced by dimethyl sulfoxide and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Glycosaminoglycans; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Leukemia, Myeloid, Acute; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Suppression of the in vitro specific antibody response by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the mouse.
Topics: Animals; Antibody Formation; Cell Adhesion; Erythrocytes; Female; Immunosuppression Therapy; Lymphocytes; Mice; Mice, Inbred C57BL; Phorbol Esters; Phorbols; Sheep; Spleen; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Production of a cytotoxin from phorbol myristate acetate-treated human promyelocytes.
Topics: Animals; Cell Line; Cytotoxins; Dactinomycin; Embryo, Mammalian; Fibroblasts; HeLa Cells; Humans; Kinetics; L Cells; Leukemia, Myeloid, Acute; Mice; Phorbols; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1984 |
[Induction of differentiation of human myelomonocytic cell lines by chemical inducers: analysis of surface antigens with monoclonal antibodies].
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Differentiation; Cell Line; Cells, Cultured; Granulocytes; Humans; Leukemia, Myeloid, Acute; Monocytes; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Tumor promoting phorbol diesters: substrates for diacylglycerol lipase.
Topics: Animals; Carbon Radioisotopes; Cell Line; Humans; Kinetics; Leukemia, Myeloid, Acute; Lipoprotein Lipase; Male; Phorbols; Phospholipids; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate; Tritium | 1984 |
Phorbol 12,13-dibutyrate enhances lateral redistribution of membrane glycoproteins in human blood lymphocytes.
Topics: Glycoproteins; Humans; Immunologic Capping; Lymphocytes; Membrane Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1984 |
Phosphorylation and dephosphorylation of human promyelocytic leukemia cell (HL-60) proteins by tumor promoter.
Topics: Autoradiography; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Myeloid, Acute; Molecular Weight; Neoplasm Proteins; Phorbols; Phosphorylation; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of denuded mouse oocyte meiotic maturation by tumor-promoting phorbol esters and its reversal by retinoids.
Topics: Animals; Colforsin; Diterpenes; Drug Interactions; Female; Meiosis; Mice; Oocytes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Retinoids; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices.
Topics: Animals; Caenorhabditis elegans Proteins; Carbachol; Carcinogens; Carrier Proteins; Hippocampus; Inositol; Inositol Phosphates; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1984 |
Differential phosphorylation events associated with phorbol ester effects on acceleration versus inhibition of cell growth.
Topics: Animals; Blood Platelets; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cells, Cultured; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Mice; Mice, Inbred Strains; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Proteins; Skin; Tetradecanoylphorbol Acetate | 1984 |
Membrane lipid dynamics in human promyelocytic leukemia cells sensitive and resistant to 12-O-tetradecanoylphorbol-13-acetate induction of differentiation.
Topics: Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Drug Resistance; Fluorescence Polarization; Genetic Variation; Humans; Leukemia, Myeloid, Acute; Membrane Fluidity; Membrane Lipids; Muramidase; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Biological activity of a fluorescent 12-O-tetradecanoyl-phorbol-13-acetate derivative.
Topics: Animals; Cricetinae; Cricetulus; Dansyl Compounds; Fluorescence; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester tumor promoters specifically stimulate choline phospholipid metabolism in human leukemic cells.
Topics: Acetates; Acetic Acid; Caenorhabditis elegans Proteins; Carbon Radioisotopes; Carcinogens; Carrier Proteins; Cells, Cultured; Choline; Humans; Leukemia, Hairy Cell; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylcholines; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium | 1984 |
Intercellular communication, cell differentiation and tumour promotion.
Topics: Amnion; Animals; Carcinogens; Cell Communication; Cell Differentiation; Cells, Cultured; Electric Conductivity; Female; Friend murine leukemia virus; Humans; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred BALB C; Neoplasms; Phorbol Esters; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate | 1984 |
Relationship between mezerein-mediated biological responses and phorbol ester receptor occupancy.
Topics: Binding, Competitive; Caenorhabditis elegans Proteins; Carrier Proteins; Dinoprostone; Diterpenes; Epidermal Growth Factor; Humans; Kinetics; Osteosarcoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Prostaglandins E; Protein Kinase C; Receptors, Drug; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoters enhance cap formation in mouse thymocytes.
Topics: Animals; Carcinogens; Cell Movement; Immunologic Capping; In Vitro Techniques; Lectins; Mice; Phenothiazines; Phorbols; T-Lymphocytes; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Opposing effects of 12-O-tetradecanoylphorbol 13-acetate on human myeloid and lymphoid cell proliferation.
Topics: Cells, Cultured; Colony-Forming Units Assay; Concanavalin A; Erythropoiesis; Granulocytes; Hematopoietic Stem Cells; Humans; Phorbols; Phytohemagglutinins; Pokeweed Mitogens; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
TPA, tumor promoter-induced suppression of immunoglobulin secretion in human blood lymphocytes.
Topics: Adult; Antibody-Producing Cells; Antigens, Surface; Carcinogens; Humans; Immunoglobulins; Immunosuppressive Agents; Lymphocyte Activation; Middle Aged; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Effects of 12-0-tetradecanoylphorbol-13-acetate (TPA) on the proliferation of granulocyte-macrophage colony-forming cells.
Topics: Animals; Bone Marrow Cells; Cell Division; Colony-Stimulating Factors; Fetus; Granulocytes; Liver; Macrophages; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
In vitro growth promotion of T-lymphocyte colonies from normal human bone marrow with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Bone Marrow Cells; Cell Division; Cells, Cultured; Humans; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Glucocorticoids and prostaglandins inhibit the induction of macrophage DNA synthesis by macrophage growth factor and phorbol ester.
Topics: Animals; Colony-Stimulating Factors; Cortisone; Dexamethasone; DNA Replication; Female; Glucocorticoids; Macrophages; Mice; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1983 |
Acquisition of deoxyguanosine resistance by TPA-induced T lymphoid lines.
Topics: Animals; Antigens, Neoplasm; Cell Differentiation; Cell Line; Culture Media; Deoxyguanosine; DNA; DNA Nucleotidylexotransferase; Dose-Response Relationship, Immunologic; Hematopoietic Stem Cells; Humans; Lymphocyte Activation; Mice; Phenotype; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Effect of phorbol ester on differentiation of human myeloid colony forming cells (CFU-C).
Topics: Bone Marrow Examination; Cell Differentiation; Cells, Cultured; Colony-Stimulating Factors; Drug Synergism; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate | 1983 |
Induction of human T colony formation by phorbol myristate acetate.
Topics: Antigens, Surface; Colony-Forming Units Assay; Humans; Lymphocyte Activation; Phorbols; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Modulation of PHA-induced T colony formation by phorbol myristic acetate.
Topics: Clone Cells; Drug Interactions; Humans; Leukocyte Count; Lymphocyte Activation; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Requirement of Ia-positive accessory cells for T-cell stimulation with 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Antilymphocyte Serum; Dose-Response Relationship, Immunologic; Female; Histocompatibility Antigens Class II; Kinetics; Lymphocyte Activation; Lymphocyte Cooperation; Macrophages; Male; Mice; Mice, Inbred A; Mice, Inbred C3H; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester mediates reversible reduction of cloned T lymphocyte cytolysis.
Topics: Animals; Clone Cells; Cytotoxicity, Immunologic; Female; Isoantigens; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1983 |
T cell lines and variant subclones with differing susceptibility to tumor promoters.
Topics: Animals; Cell Count; Clone Cells; Cocarcinogenesis; Dose-Response Relationship, Immunologic; Genetic Variation; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
The effect of fluocinolone acetonide and 12-O-tetradecanoyl-phorbol-13-acetate on the binding and biological activity of epidermal growth factor in rat fibroblasts.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; DNA Replication; Epidermal Growth Factor; Fibroblasts; Fluocinolone Acetonide; Ornithine Decarboxylase; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1983 |
The degree of monocyte participation in human B- and T-cell activation by phorbol myristate acetate.
Topics: Adult; B-Lymphocytes; Concanavalin A; Cyclosporins; DNA; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Immunoglobulin M; Kinetics; Lymphocyte Activation; Mitogens; Monocytes; Phorbols; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.
Topics: B-Lymphocytes; Bone Marrow; Cell Division; Cell Line; Cells, Cultured; Diterpenes; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Sézary cells with an unusual phenotype, their modulation with 12-O-tetradecanoyl phorbol-13-acetate (TPA) in vitro, and their relationship to T-cell development.
Topics: Aged; Antibodies, Monoclonal; B-Lymphocytes; Humans; Leukemia; Male; Phenotype; Phorbols; Receptors, Antigen, B-Cell; Sezary Syndrome; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Serological analysis of cell surface antigens of HL-60 cells before and after treatment with a phorbol ester tumor promoter.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Blood Platelets; Cell Line; Cell Membrane; Humans; Leukemia, Myeloid, Acute; Microscopy, Electron; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of phorbol ester-mediated interleukin-2 production by cellular differentiating agents.
Topics: Animals; Butyrates; Butyric Acid; Cell Differentiation; Cells, Cultured; Dimethyl Sulfoxide; Drug Antagonism; Interleukin-2; Kinetics; Lymphocyte Activation; Lymphocytes; Methylurea Compounds; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate; Thymus Gland | 1983 |
Monocyte-independent stimulation of human B lymphocytes by phorbol myristate acetate.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Separation; Drug Synergism; Humans; Immunoglobulin M; Kinetics; Lymphocyte Activation; Monocytes; Phorbols; Staphylococcus aureus; Tetradecanoylphorbol Acetate | 1983 |
The growth of cultured human foreskin keratinocytes is not stimulated by a tumor promoter.
Topics: Cell Division; Cells, Cultured; Epidermal Growth Factor; Humans; Male; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1984 |
Induction of human T-lymphocyte colonies by phorbol myristate acetate.
Topics: Cells, Cultured; Clone Cells; Dose-Response Relationship, Drug; Humans; Lymphocyte Activation; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
TPA (12-O-tetradecanoyl-phorbol-13-acetate) activation and differentiation of human peripheral B lymphocytes.
Topics: Antibodies, Monoclonal; B-Lymphocytes; Cell Differentiation; Cells, Cultured; DNA; Humans; Immunoglobulin D; Immunoglobulins; Lymphocyte Activation; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1984 |
Phenotypic modulation of chronic lymphocytic leukemia cells by phorbol ester: induction of IgM secretion and changes in the expression of B cell-associated surface antigens.
Topics: Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Cell Transformation, Neoplastic; Humans; Immunoglobulin M; Kinetics; Leukemia, Lymphoid; Phenotype; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1984 |
Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemotaxis; Epidermal Growth Factor; Epithelium; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Kirsten murine sarcoma virus; Mice; Phorbols; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1984 |
Functional studies on B-cell hybridomas with B-cell surface antigens. III. Differentiative response to phorbol esters.
Topics: Animals; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Female; Histocompatibility Antigens Class II; Hybridomas; Immunoglobulin M; Mice; Mice, Inbred C57BL; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin | 1984 |
Enhancement of human T lymphocyte colony formation by 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Granulocytes; Humans; Interleukin-2; Phorbols; Phytohemagglutinins; Stem Cells; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
The tumor promoter phorbol-12,13-dibutyrate [P(Bu)2] stimulates cytotoxic activity of human blood lymphocytes.
Topics: Cell Adhesion; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Effects of tumour promoter phorbol myristate acetate on mouse lymphocytes: selective inhibition of B cell activation by mitogens and antigens.
Topics: Animals; Antibody Formation; B-Lymphocytes; Dose-Response Relationship, Immunologic; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred Strains; Mitogens; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Activation of T lymphocytes by 12-O-tetradecanoylphorbol-13-acetate is resistant to inhibition by cyclosporin A.
Topics: Animals; Cyclosporins; In Vitro Techniques; Lymphocyte Activation; Phorbols; Phytohemagglutinins; Swine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1983 |
Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms.
Topics: Alkaloids; Animals; Carcinogens; Cell Adhesion; Cells, Cultured; Clone Cells; Culture Media; DNA; Epidermal Growth Factor; Fibroblasts; Kinetics; Lyngbya Toxins; Mice; Mice, Inbred C3H; Palmitoylcarnitine; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Diterpenes; Epidermal Growth Factor; Gangliosides; Glucosamine; Mice; Phorbol Esters; Phorbols; Skin; Terpenes; Tetradecanoylphorbol Acetate | 1984 |
Phorbol myristate acetate induction of lymphotoxins from continuous human B lymphoid cell lines in vitro.
Topics: Antibodies; B-Lymphocytes; Cell Line; Clone Cells; Humans; Kinetics; Lymphotoxin-alpha; Molecular Weight; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester increases the level of interleukin 2 mRNA in mitogen-stimulated human lymphocytes.
Topics: Animals; Female; Humans; Interleukin-2; Lymphocyte Activation; Mice; Oocytes; Palatine Tonsil; Phorbols; Phytohemagglutinins; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1984 |
Alterations in cell surface phenotype of T- and B-cell chronic lymphocytic leukemia cells following in vitro differentiation by phorbol ester.
Topics: Antigens, Surface; B-Lymphocytes; Cell Differentiation; Histocompatibility Antigens Class II; Humans; Immunoglobulins; Leukemia, Lymphoid; Phenotype; Phorbols; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Differentiation of ovine immature B cells upon exposure to phorbol myristate acetate.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Phorbols; Receptors, Antigen, B-Cell; Sheep; Tetradecanoylphorbol Acetate | 1984 |
Effects of 12-o-tetradecanoyl-phorbol-13-acetate (TPA) on the colony growth of human T lymphocytes.
Topics: Clone Cells; Dose-Response Relationship, Drug; Humans; Lymphocyte Activation; Phorbols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters inactivate the lytic apparatus of cytotoxic T lymphocytes.
Topics: Animals; Binding Sites; Cytotoxicity, Immunologic; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Phorbols; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1984 |
[Artifactual interaction of PMA (phorbol myristate acetate) in the determination of interleuken 2 (IL 2) activity].
Topics: Animals; Humans; Interleukin-2; Mice; Phorbols; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
The effects of tumor-promoting phorbol esters on human granulopoiesis in vitro.
Topics: Bone Marrow; Bone Marrow Cells; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Colony-Stimulating Factors; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Macrophages; Monocytes; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Distinctive phorbol ester-induced morphological and surface antigen changes in mycosis fungoides, the Sézary syndrome, and adult T-cell leukemia.
Topics: Adult; Antigens, Surface; Cell Transformation, Neoplastic; Cells, Cultured; Humans; Kinetics; Leukemia; Mycosis Fungoides; Phenotype; Phorbols; Sezary Syndrome; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1984 |
12-O-Tetradecanoylphorbol-13-acetate (TPA) directly inhibits spontaneous immunoglobulin secretion by in vivo antigen-induced human lymphoblastoid B cells.
Topics: Antibodies, Bacterial; Antigens, Bacterial; B-Lymphocytes; Humans; Immunoglobulin G; Immunosuppressive Agents; Lymphocyte Activation; Monocytes; Phorbols; T-Lymphocytes; Tetanus Toxoid; Tetradecanoylphorbol Acetate | 1984 |
Effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate on recovery of methotrexate-, N-(phosphonacetyl)-L-aspartate-, and cadmium-resistant colony-forming mouse and hamster cells.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cadmium; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Resistance; Kinetics; Lung; Methotrexate; Mice; Organophosphorus Compounds; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate | 1983 |
Effects of a tumor promoter on phospholipid metabolism in HeLa cells.
Topics: HeLa Cells; Humans; Kinetics; Phorbols; Phosphates; Phospholipids; Phosphorus Radioisotopes; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
12-O-tetradecanoylphorbol-13-acetate-induced effects in fibroblasts from humans predisposed to colon cancer.
Topics: Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Clastogenic action of tumor promoter phorbol-12-myristate-13 acetate in mixed human leukocyte cultures.
Topics: Blood Platelets; Cells, Cultured; Chromosome Aberrations; Culture Media; Humans; Leukocytes; Lymphocytes; Monocytes; Mutagens; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma.
Topics: Adenoma; Animals; Lung; Lung Neoplasms; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Phorbols; Polyamines; Tetradecanoylphorbol Acetate | 1983 |
Soluble phorbol ester binding sites and phospholipid- and calcium-dependent protein kinase activity in cytosol of chick oviduct.
Topics: Animals; Binding Sites; Calcium; Chickens; Cytosol; Enzyme Activation; Female; Oviducts; Phorbols; Phosphatidylserines; Phospholipids; Protein Kinases; Tetradecanoylphorbol Acetate | 1983 |
Tumor-promoting phorbol esters inhibit procollagen synthesis at a pretranslational level in JB-6 mouse epidermal cells.
Topics: Animals; Cells, Cultured; Epidermis; Gene Expression Regulation; Mice; Phorbols; Procollagen; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1983 |
A comparison of the mitogenic effects of a phorbol ester on lymphocytes from bovine spleen, lymph node and peripheral blood.
Topics: Animals; Cattle; Dose-Response Relationship, Immunologic; Drug Synergism; Female; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Mitogens; Phorbols; Phytohemagglutinins; Spleen; Tetradecanoylphorbol Acetate | 1983 |
Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters.
Topics: Drug Interactions; Flavonoids; HeLa Cells; Humans; Kaempferols; Luteolin; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate | 1983 |
The induction of ornithine decarboxylase by phorbol 12-myristate 13-acetate or by serum is inhibited by antioxidants.
Topics: Animals; Antioxidants; Blood; Catalase; Cell Line; Culture Media; Enzyme Induction; Female; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1983 |
Effects of amino acid treatments on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo and in vitro.
Topics: Amino Acids; Animals; Arginine; Canavanine; Enzyme Induction; Female; Kinetics; Mice; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Tetradecanoylphorbol Acetate | 1983 |
Effect of fluphenazine on the stimulation of calcium-sensitive phospholipid-dependent protein kinase by 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Animals; Calcium; Fluphenazine; Phorbols; Phospholipids; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1983 |
The phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate and stimulation of 3H-choline incorporation into endoplasmic reticulum membranes and other subcellular fractions of Krebs II ascites cells during in vitro incubation.
Topics: Animals; Carcinoma, Krebs 2; Cells, Cultured; Endoplasmic Reticulum; Intracellular Membranes; Mice; Phorbols; Phosphatidylcholines; Stimulation, Chemical; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Effect of 12-O-tetradecanoyl-phorbol-13-acetate and 3-methylcholanthrene on the toxicity of nicotine applied to mouse skin.
Topics: Administration, Topical; Animals; Chromatography, Gas; DNA; Female; Male; Methylcholanthrene; Mice; Nicotine; Phorbols; Skin; Skin Absorption; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Exposure of JB-6 mouse epidermal cells to 12-O-tetradecanoyl-phorbol-13-acetate is not accompanied by a significant change in total DNA-cytosine methylation.
Topics: 5-Methylcytosine; Animals; Cell Line; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1983 |
The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate.
Topics: Animals; Cartilage; Cells, Cultured; Fibroblasts; Glycosaminoglycans; Interleukin-1; Interleukin-1beta; Macrophages; Phorbols; Protein Biosynthesis; Stimulation, Chemical; Swine; Synovial Membrane; Tetradecanoylphorbol Acetate | 1983 |
Transfer of phorbol ester promotability by transfection of DNA from promotable into nonpromotable cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Mice; Mice, Inbred BALB C; Phorbols; Skin; Tetradecanoylphorbol Acetate; Transfection | 1983 |
Enhancement of aggregation of Chinese hamster V79 cells in rotation culture by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Adhesion; Cell Aggregation; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Dimethyl Sulfoxide; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on epithelial tumor induction in methylcholanthrene injected Swiss albino mice.
Topics: Animals; Drug Synergism; Female; Methylcholanthrene; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Effects of 12-O-tetradecanoylphorbol 13-acetate on the production of mRNAs for human tissue-type plasminogen activator.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Humans; Melanoma; Oocytes; Phorbols; Plasminogen Activators; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; RNA, Neoplasm; Sodium Dodecyl Sulfate; Tetradecanoylphorbol Acetate; Xenopus laevis | 1983 |
Interactions of ultraviolet radiation, 12-O-tetradecanoyl-phorbol-13-acetate and retinoic acid in the skin of hairless mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Epidermis; Male; Mice; Mice, Hairless; Mitosis; Neoplasms, Radiation-Induced; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Ultraviolet Rays | 1983 |
Changes in SRBC binding capacity and T-surface antigen expression on human peripheral blood lymphocytes stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Membrane; Humans; Lymphocyte Activation; Lymphocytes; Phorbols; Receptors, Immunologic; Rosette Formation; Tetradecanoylphorbol Acetate | 1983 |
1 alpha, 25-Dihydroxyvitamin D3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin.
Topics: Administration, Topical; Animals; Calcitriol; Female; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Radiomimetic activity of phorbol esters exerted in HeLa cells in comparison with their tumor-promoting capacity.
Topics: Cell Cycle; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mitosis; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro.
Topics: Animals; Carcinogens; Female; Macrophages; Mice; Mice, Inbred ICR; Nitroblue Tetrazolium; Phagocytosis; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Induction of murine fibrosarcomas by low dose treatment with 3-methylcholanthrene followed by promotion with 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Female; Fibrosarcoma; Methylcholanthrene; Mice; Mice, Inbred C57BL; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of DNA synthesis and sugar uptake and lack of induction of ornithine decarboxylase in human epidermal cells treated with mouse skin tumor promoters.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Deoxy Sugars; Deoxyglucose; DNA Replication; Enzyme Induction; Humans; Kinetics; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1984 |
Enhanced sensitivity of the C3H/10T1/2 cell transformation system to alkylating and chemotherapeutic agents by treatment with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Direct evidence of incorporation of 12-O-[20-2H1]tetradecanoylphorbol-13-acetate into artificial membranes as determined by deuterium magnetic resonance.
Topics: Cell Membrane; Deuterium; Dimyristoylphosphatidylcholine; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membranes, Artificial; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the incorporation of labelled precursors into RNA, DNA and protein in epidermis, dermis and subcutis from precancerous mouse skin with reference to enhanced tumorigenesis.
Topics: Animals; Carbon Radioisotopes; DNA Replication; Female; Kinetics; Leucine; Mice; Phorbols; Precancerous Conditions; Protein Biosynthesis; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic; Tritium; Uridine | 1984 |
Relation between induction of rat hepatic ornithine decarboxylase activity by tumor promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital and levels of the polyamines putrescine, spermidine and spermine, in vivo; differential effects of retinyl
Topics: Animals; Diterpenes; Enzyme Induction; Female; Kinetics; Liver; Ornithine Decarboxylase; Phorbols; Putrescine; Rats; Rats, Inbred Strains; Retinyl Esters; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Vitamin A | 1984 |
Phorbol esters inhibit LH stimulated steroidogenesis by mouse Leydig cells in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carcinogens; Kinetics; Leydig Cells; Luteinizing Hormone; Male; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Testosterone; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester stimulates the phosphorylation of rabbit erythrocyte band 4.1.
Topics: Animals; Blood Proteins; Cytoskeletal Proteins; Erythrocyte Membrane; In Vitro Techniques; Membrane Proteins; Neuropeptides; Phorbol Esters; Phorbols; Phosphorylation; Rabbits; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester tumor promoter affects the mouse epidermal gap junctions.
Topics: Animals; Cell Communication; Diterpenes; Female; Intercellular Junctions; Mice; Phorbol Esters; Phorbols; Skin; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Enhancement of clonal proliferation of mouse mast cells by a tumor-promoting phorbol ester.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; Clone Cells; Dexamethasone; Female; Kinetics; Mast Cells; Mice; Mice, Inbred BALB C; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), retinoic acid and diazepam on intercellular communication in a monolayer of rat liver epithelial cells.
Topics: Animals; Cell Communication; Cell Line; Diazepam; Epithelium; Hypoxanthines; Intercellular Junctions; Liver; Liver Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Isolation and characterization of a murine serum esterase which hydrolyzes a tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate.
Topics: Amino Acids; Animals; Esterases; Humans; Hydrolysis; Immunoelectrophoresis; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phorbols; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Differentiation-associated changes in human non-T, non-B leukemia cell lines after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).
Topics: Acid Phosphatase; Antigens, Neoplasm; Cell Differentiation; Cell Division; Cell Line; Glucuronidase; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Accelerated onset of viral transcription in adenovirus-infected HeLa cells treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Adenoviruses, Human; Cell Nucleus; Cell Transformation, Viral; Cycloheximide; DNA Replication; DNA, Viral; HeLa Cells; Humans; Kinetics; Phorbols; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1984 |
Preferential growth inhibition of human leukemic versus normal myeloid colony-forming cells by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Differentiation; Cells, Cultured; Hematopoietic Stem Cells; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Stimulation of ornithine decarboxylase activity and DNA synthesis by phorbol esters or bile acids in rat colon.
Topics: Animals; Bile Acids and Salts; Colon; Deoxycholic Acid; DNA; Enzyme Activation; Epithelium; Inflammation; Intestinal Mucosa; Male; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Rectum; Stimulation, Chemical; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
IgA release using phorbol?
Topics: Immunoglobulin A; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Hypothalamus; Peptides; Phorbols; Picrotoxin; Potassium; Rats; Sesterterpenes; Tetradecanoylphorbol Acetate | 1984 |
Visualization of protein kinases in lymphocytes stimulated to proliferate with concanavalin A or inhibited with a phorbol ester.
Topics: Animals; Autoradiography; Cattle; Concanavalin A; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Mitosis; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of gastric acid secretion by a phorbol ester: effect of 12-O-tetradecanoylphorbol-13-acetate on aminopyrine accumulation by rat parietal cells.
Topics: Aminopyrine; Animals; Gastric Acid; Gastric Mucosa; Histamine Antagonists; In Vitro Techniques; Male; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1984 |
[Effect of tumor promoting agents on the in vitro malignant transformation of the fetal rat brain cells exposed in utero to ethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Interactions; Ethylnitrosourea; Female; Fetus; In Vitro Techniques; Maternal-Fetal Exchange; Nitrosourea Compounds; Phenobarbital; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate | 1984 |
Kinetics of fibronectin release from fibroblasts in response to 12-O-tetradecanoylphorbol-13-acetate and retinoic acid.
Topics: Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Fibroblasts; Fibronectins; Kinetics; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Tritium | 1984 |
[Mechanisms of the tumor promoting effect of 12-0-tetradecanoyl phorbol 13-acetate on the ethylnitrosourea induced transplacental neurogenic carcinogenesis].
Topics: Animals; Brain Neoplasms; Carcinogens; Chromosome Aberrations; DNA, Neoplasm; Ethylnitrosourea; Female; Gene Expression Regulation; In Vitro Techniques; Maternal-Fetal Exchange; Neoplasm Proteins; Phorbols; Pregnancy; Rats; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Thymidine | 1984 |
The direct effects of biological response modifiers on epidermal cells.
Topics: Animals; Cells, Cultured; DNA; Electrophoresis; Lymphocytes; Mice; Mice, Inbred BALB C; Minoxidil; Mitosis; Molecular Weight; Phenytoin; Phorbols; Pyrimidines; Skin; Tetradecanoylphorbol Acetate | 1984 |
Incidence of radiation lymphomas in C57BL/6 mice is not promoted after intraperitoneal treatment with the phorbol ester tetradecanoylphorbol acetate.
Topics: Animals; Autopsy; Cocarcinogenesis; Female; Injections, Intraperitoneal; Lymphoma; Mice; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
12-O-Tetradecanoylphorbol-13-acetate stimulation of DNA synthesis in cultured preneoplastic familial polyposis colonic epithelial cells but not in normal colonic epithelial cells.
Topics: Cells, Cultured; Colon; Colonic Polyps; DNA Replication; Epithelium; Humans; Microscopy, Electron; Organ Culture Techniques; Phorbols; Precancerous Conditions; Reference Values; Tetradecanoylphorbol Acetate | 1984 |
Effect of catalase on the proliferation of human lymphocytes to phorbol myristate acetate.
Topics: Antibody-Dependent Cell Cytotoxicity; Catalase; Humans; Hydrogen Peroxide; Kinetics; Lymphocyte Activation; Lymphocytes; Monocytes; Oxidation-Reduction; Oxygen; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol myristate acetate inhibits immunoglobulin synthesis by human peripheral blood lymphocytes.
Topics: B-Lymphocytes; Cell Survival; Cells, Cultured; Hemolytic Plaque Technique; Immunoglobulins; Kinetics; Lymphocytes; Phorbols; Pokeweed Mitogens; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Affinity alteration of insulin receptor induced by a phorbol ester.
Topics: Cell Line; Growth Hormone; Humans; Insulin; Kinetics; Lymphocytes; Macrophages; Phorbols; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1982 |
Induction of antibody-dependent and nonspecific tumor killing in human monocytic leukemia cells by nonlymphocyte factors and phorbol ester.
Topics: Antibody-Dependent Cell Cytotoxicity; Cell Line; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Phagocytosis; Phorbols; Receptors, Complement; Receptors, Fc; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms | 1982 |
Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Autoantibody and tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Autoantibodies; Croton Oil; Female; Mice; Mice, Inbred A; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chemical Phenomena; Chemistry; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1980 |
Promotion-like enhancement of tracheal carcinogenesis in rats by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Dose-Response Relationship, Drug; Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate; Tracheal Neoplasms | 1980 |
Neutrophil aggregation: evidence for a different mechanism of action by phorbol myristate acetate.
Topics: Arachidonic Acids; Calcimycin; Calcium; Cell Aggregation; Cytochalasin B; Dose-Response Relationship, Drug; Glucose; Humans; In Vitro Techniques; Magnesium; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristic acetate enhances the production of interleukin 2.
Topics: Animals; Concanavalin A; Cytotoxicity, Immunologic; Female; Interleukin-1; Interleukin-2; Lymphocyte Activation; Lymphocyte Cooperation; Lymphokines; Male; Mice; Phorbols; Proteins; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Fetus; Gestational Age; Mice; Phorbols; Pregnancy; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
The nature of the epidermal growth produced by the first application of 12-0-tetradecanoyl-phorbol-13-acetate on the skin of mice initiated with dimethylbenzanthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Epidermis; Female; Hyperplasia; Mice; Mitosis; Organ Size; Phorbols; Proteins; Tetradecanoylphorbol Acetate | 1981 |
Activation of the metabolism of the fatty acyl group in granulocyte phospholipids by phorbol myristate acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids; Glycerol; Granulocytes; Guinea Pigs; Kinetics; Palmitic Acid; Palmitic Acids; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate | 1981 |
Protease inhibitor antipain suppresses 12-O-tetradecanoyl-phorbol-13-acetate induction of plasminogen activator in transformable mouse embryo fibroblasts.
Topics: Animals; Antipain; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Induction; Female; Fibroblasts; Leupeptins; Mice; Oligopeptides; Phorbols; Plasminogen Activators; Plasminogen Inactivators; Pregnancy; Tetradecanoylphorbol Acetate; Time Factors; Trypsin Inhibitor, Bowman-Birk Soybean | 1981 |
Intracellular calcium and skin tumor promotion: calcium regulation of the induction of epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Calcium; Carboxy-Lyases; Edetic Acid; Enzyme Induction; Female; Kinetics; Magnesium; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1981 |
Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6--20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Female; Gestational Age; Mice; Neoplasms, Experimental; Phorbols; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors; Tetradecanoylphorbol Acetate | 1981 |
Phospholipase activity in skin after application of phorbol esters and 3-methylcholanthrene.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; DNA; Male; Methylcholanthrene; Mice; Phorbol Esters; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Skin; Tetradecanoylphorbol Acetate | 1981 |
Chemiluminescence of human neutrophils induced by soluble stimuli: effect of divalent cations.
Topics: Anti-Bacterial Agents; Calcimycin; Calcium; Cations, Divalent; Concanavalin A; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Humans; Luminescent Measurements; Magnesium; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Interaction of phorbol esters with lipid bilayers : thermotropic changes in fluorescence polarization, phase transition and calcium ionophoresis.
Topics: Calcimycin; Calcium; Carcinogens; Diffusion; Dimyristoylphosphatidylcholine; Lipid Bilayers; Phorbol Esters; Phorbols; Phosphatidylcholines; Pulmonary Surfactants; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature; Tetradecanoylphorbol Acetate | 1981 |
Neutrophil activation monitored by flow cytometry: stimulation by phorbol diester is an all-or-none event.
Topics: Cell Aggregation; Dose-Response Relationship, Drug; Edetic Acid; Flow Cytometry; Microscopy, Fluorescence; NAD; Neutrophils; Oxidation-Reduction; Oxygen; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
A phorbol ester (TPA) can replace macrophages in human lymphocyte cultures stimulated with a mitogen but not with an antigen.
Topics: Antigens, Bacterial; Humans; Interleukin-1; Lymphocyte Activation; Macrophages; Mitogens; Phorbols; Phytohemagglutinins; Proteins; Tetanus Toxoid; Tetradecanoylphorbol Acetate | 1982 |
Different effects of dimethylbenz(alpha)anthracene and tetradecanoylphorbol acetate on differentiation of mast cells in the skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Bone Marrow Transplantation; Cell Differentiation; Cell Division; Chimera; Female; Male; Mast Cells; Mice; Mice, Inbred C57BL; Phorbols; Skin; Tetradecanoylphorbol Acetate; X-Rays | 1982 |
Early induction of the arachidonic acid cascade and stimulation of DNA synthesis by TPA in murine and guinea pig epidermal cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cells, Cultured; Dinoprost; Dinoprostone; DNA; Epidermis; Guinea Pigs; Indomethacin; Mice; Ornithine Decarboxylase; Phorbols; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1982 |
How can altered differentiation induced by 12-O-tetradecanoylphorbol-13-acetate be related to tumor promotion?
Topics: Animals; Cell Differentiation; Cells, Cultured; Cocarcinogenesis; DNA; Fishes; Genotype; Melanoma; Melanophores; Monophenol Monooxygenase; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1982 |
Possible molecular mechanisms of action of tumor promoters.
Topics: Alkaloids; Alprostadil; Amino Acid Sequence; Carcinogens; Chemical Phenomena; Chemistry; Enzyme Activation; Lyngbya Toxins; Phorbols; Phospholipases; Phospholipases A; Prostaglandins E; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Ionophoretic effect of tumor promoter phorbol diester: a clue to its insulinotropic action?
Topics: Animals; Biological Transport; Calcimycin; Calcium; Glucose; Insulin; Islets of Langerhans; Liposomes; Membrane Fluidity; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1982 |
Diterpene ester-mediated two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cricetinae; Female; Guinea Pigs; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Milk; Neoplasms, Experimental; Phorbols; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vaginal Neoplasms | 1982 |
Induction of differentiation of human promyelocytic leukemia (HL-60) cells by teleocidin and phorbol-12-myristate-13-acetate.
Topics: Alkaloids; Carcinogens; Cell Differentiation; Cells, Cultured; DNA, Neoplasm; Humans; Leukemia, Myeloid, Acute; Lyngbya Toxins; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism.
Topics: Adenoviruses, Human; Alkaloids; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Choline; Humans; Lyngbya Toxins; Melanins; Melanoma; Mice; Muscles; Phorbols; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Carboxy-Lyases; Catechols; Dinoprostone; Female; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Ornithine Decarboxylase; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandins E; Quinacrine; Skin; Tetracaine; Tetradecanoylphorbol Acetate | 1982 |
Monoclonal human B lymphoma cells respond to DNA synthesis to anti-immunoglobulins in the presence of the tumour promotor TPA.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; DNA; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; In Vitro Techniques; Lymphocyte Activation; Lymphoma; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumor promotor 12-O-tetradecanoylphorbol-13-acetate-induced insulin secretion: inhibition by phospholipase A2-and lipoxygenase-inhibitors.
Topics: Animals; Enzyme Activation; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lipoxygenase; Lipoxygenase Inhibitors; Male; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1982 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetra-decanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Hyperplasia; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Phorbols; Rats; Rats, Inbred F344; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
Calcium-dependent release of arachidonic acid from a murine epidermal cell line induced by the tumor promoter TPA or ionophore A 23187: dissection of ionophoretic and phospholipase A2-stimulating activity.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcimycin; Calcium; Cell Line; Enzyme Activation; Ionophores; Mice; Phorbols; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate | 1982 |
3T3 fibroblasts are stimulated by 12-O-tetradecanoyl-phorbol-13-acetate to produce thymocyte-activating factors.
Topics: Cells, Cultured; Concanavalin A; Fibroblasts; Growth Substances; Interleukin-1; Lymphocyte Activation; Phorbol Esters; Phorbols; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1982 |
Stimulation of deacylation in Madin-Darby canine kidney cells. Specificity of deacylation and prostaglandin production in 12-O-tetradecanoylphorbol-13-acetate-treated cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cell Line; Dogs; Fatty Acids, Unsaturated; Kidney; Kinetics; Linoleic Acid; Linoleic Acids; Phorbols; Prostaglandins; Tetradecanoylphorbol Acetate | 1982 |
Independent and synergistic thymocyte proliferative activities of PMA and IL 1.
Topics: Animals; Cells, Cultured; Drug Synergism; Humans; Interleukin-1; Lymphocyte Activation; Mice; Phorbols; Proteins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Diazonium Compounds; Male; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
The control of phospholipid methylation by phorbol diesters in differentiating human myeloid HL-60 leukemia cells.
Topics: Alkaloids; Cell Differentiation; Cell Line; Humans; Leukemia, Myeloid, Acute; Lyngbya Toxins; Methylation; Methyltransferases; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylethanolamine N-Methyltransferase; Phospholipids; Tetradecanoylphorbol Acetate | 1982 |
Endogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA.
Topics: Calcimycin; Chemotactic Factors; Humans; Kinetics; Methionine; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate | 1982 |
Effect of phorbol esters on alloimmune cytolysis.
Topics: Animals; Cell Survival; Cytotoxicity, Immunologic; Lymphoma; Mast-Cell Sarcoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Carboxy-Lyases; Dinoprostone; Female; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase Inhibitors; Phorbols; Prostaglandins E; Pyrazoles; Skin; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes.
Topics: Arachidonic Acids; Cells, Cultured; Chromosome Aberrations; Cyclooxygenase Inhibitors; Humans; Lymphocytes; Molecular Weight; Mutagens; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.
Topics: Acetophenones; Animals; Catechols; Enzyme Inhibitors; Female; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
The use of a tumor promoter for the detection of individuals with the Gardner syndrome.
Topics: Adolescent; Adult; Aged; Carcinogens; Cells, Cultured; Child; Clone Cells; Dose-Response Relationship, Drug; False Negative Reactions; Female; Fibroblasts; Gardner Syndrome; Humans; Male; Middle Aged; Pedigree; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1983 |
TPA affects early and late stages of chemically-induced transformation in mouse submandibular salivary epithelial cells in vitro.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Dimethyl Sulfoxide; Epithelial Cells; Epithelium; Male; Mice; Phenotype; Phorbols; Submandibular Gland; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1983 |
Hexose uptake as an indicator of JB6 mouse epidermal cell resistance to the mitogenic activity of TPA.
Topics: Animals; Biological Transport, Active; Cell Division; Cell Line; Cell Transformation, Neoplastic; Deoxy Sugars; Deoxyglucose; Drug Resistance; Epidermis; Interphase; Kinetics; Mice; Mitogens; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Influence of the tumour promoter TPA upon erythroid burst formation in vitro.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Hematopoietic Stem Cells; Interphase; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate alters state, fluidity and hydration of 1,2-diacyl-sn-glycero-3-phosphocholine bilayers.
Topics: Calorimetry, Differential Scanning; Diphenylhexatriene; Fluorescence Polarization; Lipid Bilayers; Models, Biological; Molecular Conformation; Phorbols; Phosphatidylcholines; Tetradecanoylphorbol Acetate | 1983 |
Induction of Epstein-Barr virus early antigens by corticosteroids: inhibition by TPA and retinoic acid.
Topics: Adrenal Cortex Hormones; Animals; Antigens, Viral; Burkitt Lymphoma; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Humans; Kinetics; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Virus Activation | 1983 |
Lung vascular effects of phorbol myristate acetate in awake sheep.
Topics: Animals; Blood Vessels; Cell Count; Chemotaxis; Consciousness; Granulocytes; Humans; In Vitro Techniques; Lung; Lymph; Phorbols; Prostaglandins; Pulmonary Circulation; Sheep; Tetradecanoylphorbol Acetate | 1983 |
Tumor promotion by phorbol esters in skin: evidence for a memory effect.
Topics: Animals; Carcinogens; Cell Line; Epidermis; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbol Esters; Phorbols; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Identification of a calcium- and phospholipid- dependent phorbol ester binding activity in the soluble fraction of mouse tissues.
Topics: Animals; Calcium; Female; Mice; Phorbols; Phospholipids; Protein Kinases; Solubility; Tetradecanoylphorbol Acetate; Tissue Distribution | 1983 |
The effects of serum and phorbol ester tumor promoter on ornithine decarboxylase activity in Swiss 3T3 cells.
Topics: Animals; Blood; Carboxy-Lyases; Cells, Cultured; Mice; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the proliferation and differentiation of normal and leukemic myeloid progenitor cells.
Topics: Bone Marrow; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media; Cytarabine; Humans; Leukemia; Macrophages; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Lymphokine and phorbol (PMA) regulation of complement (C2) synthesis using U937.
Topics: Cell Division; Cell Line; Complement C2; Cycloheximide; Dimethyl Sulfoxide; Humans; Lymphokines; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
12-0-Tetradecanoylphorbol-13-acetate-induced amplification of mesenchymal tumorigenesis in the mouse skin.
Topics: Animals; Cocarcinogenesis; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbols; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Glucose uptake and ornithine decarboxylase activity in tetradecanoyl phorbol acetate non-proliferative variants.
Topics: Animals; Biological Transport; Carboxy-Lyases; Cell Division; Cell Line; Deoxyglucose; Drug Resistance; Enzyme Induction; Glucose; Mice; Mutation; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
The nuclear-associated endoplasmic reticulum is an early target for the action of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in C3H/10T1/2 fibroblasts.
Topics: Animals; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Choline; Endoplasmic Reticulum; Intracellular Membranes; Membrane Lipids; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
The tumourigenic and carcinogenic effect of 12-0-tetradecanoylphorbol-13-acetate when applied to the skin of BALB/cA and hairless (hr/hr) mice.
Topics: Amyloidosis; Animals; Female; Kupffer Cells; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Pulmonary injury induced by phorbol myristate acetate following intravenous administration in rabbits. Acute respiratory distress followed by pulmonary interstitial pneumonitis and pulmonary fibrosis.
Topics: Animals; Disease Models, Animal; Humans; Injections, Intravenous; Lung; Neutrophils; Phorbols; Pulmonary Fibrosis; Rabbits; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate | 1983 |
Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits.
Topics: Animals; Lung; Methylprednisolone; Neutrophils; Phorbols; Premedication; Pulmonary Edema; Quinacrine; Rabbits; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate | 1983 |
Effect of polycyclic aromatic compounds and phorbol esters on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in mouse liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carboxy-Lyases; Kinetics; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ornithine Decarboxylase; Phorbols; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Tetradecanoylphorbol Acetate | 1983 |
Granulocytes and phorbol myristate acetate increase permeability to albumin of cultured endothelial monolayers and isolated perfused lungs. Role of oxygen radicals and granulocyte adherence.
Topics: Animals; Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Cytochalasin B; Endothelium; Granulocytes; Lung; Oxygen; Phorbols; Pulmonary Edema; Rabbits; Serum Albumin, Bovine; Swine; Tetradecanoylphorbol Acetate | 1983 |
Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene.
Topics: Animals; Benz(a)Anthracenes; Female; Mice; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced induction in Epstein-Barr virus early antigen in Raji cells.
Topics: Antigens, Viral; Benzoflavones; beta-Naphthoflavone; Burkitt Lymphoma; Cells, Cultured; Cholic Acid; Cholic Acids; Estradiol; Humans; Hydrocortisone; Phorbols; Quercetin; Rutin; Sweetening Agents; Tetradecanoylphorbol Acetate; Virus Activation; Vitamin A | 1983 |
Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Administration, Topical; Animals; Anisoles; Butylated Hydroxyanisole; Carboxy-Lyases; Dose-Response Relationship, Drug; Enzyme Induction; Epidermis; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Specific TPA-induced protein phosphorylations in cultured myotubes.
Topics: Animals; Chick Embryo; Culture Techniques; Molecular Weight; Muscle Proteins; Muscles; Phorbols; Phosphorylation; Tetradecanoylphorbol Acetate | 1983 |
Glucocorticoid receptor levels in mouse skin after repetitive applications of 12-O-tetradecanoylphorbol-13-acetate and mezerein.
Topics: Administration, Topical; Animals; Diterpenes; Female; Mice; Phorbol Esters; Phorbols; Receptors, Glucocorticoid; Receptors, Steroid; Skin; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Influence of tumor-promoting phorbol esters on the phosphorylation of membrane proteins in lymphocytes.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Lymphocytes; Membrane Proteins; Molecular Weight; Phorbol Esters; Phorbols; Phosphorylation; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Factors influencing the promotion of transformation in chemically-initiated C3H/10T1/2 Cl 8 mouse embryo fibroblasts.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Female; Fibroblasts; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Phorbols; Pregnancy; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Growth stimulation and tumor promotion in skin.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Mice; Phorbol Esters; Phorbols; Prostaglandins; Skin; Tetradecanoylphorbol Acetate | 1983 |
[Effect of phorbolmyristate acetate and bacterial lipopolysaccharides on the luminal chemiluminescence of neutrophil granulocytes].
Topics: Humans; Lipopolysaccharides; Luminescent Measurements; Luminol; Male; Neutrophils; Phagocytosis; Phorbols; Staphylococcus; Tetradecanoylphorbol Acetate | 1983 |
Ornithine decarboxylase activity and DNA synthesis in primary and transformed hamster epidermal cells exposed to tumor promoter.
Topics: Animals; Animals, Newborn; Carboxy-Lyases; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA Replication; Kinetics; Mesocricetus; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1983 |
Effects of single applications of 12-O-tetradecanoylphorbol-13-acetate, mezerein, or ethylphenylpropiolate on DNA synthesis and polyamine levels in hairless mouse epidermis.
Topics: Alkynes; Animals; Antineoplastic Agents, Phytogenic; Diterpenes; DNA Replication; Female; Kinetics; Male; Mice; Mice, Nude; Phorbol Esters; Phorbols; Polyamines; Putrescine; Skin; Spermidine; Spermine; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
The specific appearance of a 65,000 dalton protein in the nuclear associated endoplasmic reticulum of Krebs II ascites cells early after treatment with the phorbol ester TPA.
Topics: Animals; Carcinoma, Krebs 2; Cell Nucleus; Endoplasmic Reticulum; Kinetics; Mice; Mice, Inbred BALB C; Molecular Weight; Neoplasm Proteins; Nucleoproteins; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Limiting factors of the V79 cell metabolic cooperation assay for tumor promoters.
Topics: Animals; Carcinogens; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dimethyl Sulfoxide; Dinitrobenzenes; Drug Resistance; Kinetics; Lung; Nitrobenzenes; Phorbols; Tetradecanoylphorbol Acetate; Thioguanine | 1983 |
Onion and garlic oils inhibit tumor promotion.
Topics: Animals; Cell Transformation, Neoplastic; Drug Antagonism; Female; Garlic; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Oils; Phorbols; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Differential response of satellite cells and embryonic myoblasts to a tumor promoter.
Topics: Age Factors; Animals; Carcinogens; Cell Differentiation; Cell Fusion; Cells, Cultured; Chick Embryo; Muscles; Phorbols; Receptors, Cholinergic; Tetradecanoylphorbol Acetate | 1983 |
Suppression of tumor promoter phorbolmyristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism.
Topics: Anti-Inflammatory Agents; Antioxidants; Chromosomes; Flufenamic Acid; Fluocinolone Acetonide; Humans; Imidazoles; Indomethacin; Lymphocytes; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Chromosome abnormalities in chronic lymphocytic leukemia revealed by TPA as a mitogen.
Topics: Adult; Aged; Chromosome Aberrations; Chromosome Disorders; Clone Cells; Female; Humans; Karyotyping; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Mitogens; Phorbols; Pokeweed Mitogens; Tetradecanoylphorbol Acetate | 1983 |
Serum lipase active in the hydrolysis of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Drug Stability; Goats; Guinea Pigs; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lipase; Male; Mice; Phorbols; Rabbits; Rats; Species Specificity; Tetradecanoylphorbol Acetate | 1983 |
Diazepam inhibition of phorbol ester tumor promotion.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Female; Male; Mice; Papilloma; Phorbols; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Tumor promoter-dependent mouse leukemia cell line.
Topics: Acetates; Alkaloids; Animals; Cell Division; Diterpenes; Indoles; Leukemia, Experimental; Lymphokines; Mice; Phorbols; Polymers; Tetradecanoylphorbol Acetate | 1983 |
Epidermal cell cycle and transit times during hyperplastic growth induced by abrasion or treatment with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Cycle; Epidermal Cells; Epidermis; Female; Hyperplasia; Mice; Phorbols; Tetradecanoylphorbol Acetate; Thymidine | 1983 |
Role of intercellular communication in the promotion of C3H/10T1/2 cell transformation.
Topics: Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Kinetics; Mice; Mice, Inbred C3H; Phorbols; Ribonucleotides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Uridine | 1983 |
Possible role of calmodulin in stimulation of hexose transport by 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.
Topics: Animals; Biological Transport, Active; Calcium; Calcium-Binding Proteins; Calmodulin; Chick Embryo; Deoxy Sugars; Deoxyglucose; Fibroblasts; Kinetics; Phorbols; Tetradecanoylphorbol Acetate; Trifluoperazine | 1983 |
The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cell Membrane; Electricity; Exocytosis; Kinetics; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Purification of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis.
Topics: Animals; Carboxy-Lyases; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epidermis; Female; Mice; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages.
Topics: Acid Phosphatase; Actins; Animals; Cytochalasins; Cytoskeleton; Lysosomes; Macrophages; Mice; Microtubules; Mitochondria; Phorbols; Tetradecanoylphorbol Acetate; Tubulin | 1980 |
Effect of RNA and protein synthesis inhibitors on the release of inflammatory mediators by macrophages responding to phorbol myristate acetate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Cycloheximide; Dactinomycin; In Vitro Techniques; Macrophages; Male; Mice; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate; Zymosan | 1980 |
H2O2-releasing function of macrophages activated with various mycobacteria based on wheat germ agglutinin and phorbol myristate acetate triggering.
Topics: Animals; Ascitic Fluid; Concanavalin A; Female; Hydrogen Peroxide; Lectins; Macrophages; Mice; Mycobacterium; Phorbols; Species Specificity; Tetradecanoylphorbol Acetate; Wheat Germ Agglutinins | 1981 |
Phorbol myristate acetate induces the secretion of an elastase by populations of resident and elicited mouse peritoneal macrophages.
Topics: Animals; Ascitic Fluid; Dexamethasone; Elastin; Indomethacin; Isotope Labeling; Macrophages; Male; Mice; Pancreatic Elastase; Phorbols; Protease Inhibitors; Tetradecanoylphorbol Acetate; Tritium | 1980 |
Terminal differentiation in human promyelocytic leukaemic cells in the absence of DNA synthesis.
Topics: Cell Differentiation; Cells, Cultured; DNA; Humans; Interphase; Leukemia, Myeloid; Phagocytosis; Phorbols; Preleukemia; Tetradecanoylphorbol Acetate | 1980 |
Differentiation of human leukemias in response to 12-0-tetradecanoylphorbol-13-acetate in vitro.
Topics: Cell Adhesion; Cell Aggregation; Cell Transformation, Neoplastic; Esterases; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Effect of maturation on the response of human promyelocytic leukemia cells (HL-60) to the tumor promoter 12-o-tetradecanolyphorbol-13-acetate.
Topics: Cell Differentiation; Fibrinolysis; Hexosephosphates; Humans; Intracellular Membranes; Leukemia, Myeloid, Acute; NADH, NADPH Oxidoreductases; NADPH Oxidases; Oxygen Consumption; Phorbols; Plasminogen; Receptors, Complement; Receptors, Drug; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate stimulates macrophage differentiation and replication and alters granulopoiesis and leukemogenesis in long-term bone marrow cultures.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Granulocytes; Hematopoiesis; Leukemia, Myeloid, Acute; Macrophages; Mice; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Genetic Markers; Lung; Mitosis; Mutation; Ovary; Phorbols; Recombination, Genetic; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1980 |
Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
Topics: Adenosylmethionine Decarboxylase; Anesthetics, Local; Animals; Carboxy-Lyases; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Epidermis; Female; Lidocaine; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Phorbols; Putrescine; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1980 |
Dose-dependent effects of a tumor promotor on blast cell progenitors in human myeloblastic leukemia.
Topics: Cells, Cultured; Clone Cells; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Phorbol ester tumor promoters block the transition from the early to the heme-dependent late program of Friend cell differentiation.
Topics: Animals; Cell Differentiation; Friend murine leukemia virus; Heme; Hemin; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Tumour promoters induce macrophage differentiation in human myeloid cells from patients with acute and chronic myelogenous leukaemia.
Topics: Bone Marrow; Cell Differentiation; Cells, Cultured; Diterpenes; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Macrophages; Phorbols; Spleen; Tetradecanoylphorbol Acetate | 1981 |
PRomotion of smooth surface tumorigenicity by phorbol myristate acetate in Balb/3T3 cells and Balb/3T3 T proadipocytes.
Topics: Animals; Cell Differentiation; Cell Line; Cocarcinogenesis; Embryo, Mammalian; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Alterations in polyamine levels induced by phorbol diesters and other agents that promote differentiation in human promyelocytic leukemia cells.
Topics: Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Myeloid, Acute; Muramidase; Phorbol Esters; Phorbols; Polyamines; Putrescine; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1981 |
Down regulation of specific binding of [20-3H]phorbol 12,13-dibutyrate and phorbol ester-induced differentiation of human promyelocytic leukemia cells.
Topics: Binding Sites; Binding, Competitive; Carcinogens; Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Early changes in phosphatidylcholine metabolism in human acute promyelocytic leukemia cells stimulated to differentiate by phorbol ester.
Topics: Cell Transformation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Methylation; Phorbol Esters; Phorbols; Phosphatidylcholines; Phospholipids; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Retinoids inhibit promoter-dependent preneoplastic progression in mouse epidermal cell lines.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Mice; Phorbols; Skin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Modulation of terminal differentiation and responses to tumor promoters by retinoids in mouse epidermal cell cultures.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Enzyme Induction; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
TPA-resistance in Friend erythroleukemia cells: role of membrane lipid fluidity.
Topics: Animals; Carcinogens; Cell Line; Clone Cells; Diphenylhexatriene; Drug Resistance; Kinetics; Leukemia, Experimental; Membrane Fluidity; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1981 |
Cell cycle dependency of tumor promoter on murine erythroleukemic cells.
Topics: Animals; Benzidines; Butyrates; Butyric Acid; Cell Line; Cell Nucleus; Clone Cells; Dimethyl Sulfoxide; DNA; Interphase; Leukemia, Erythroblastic, Acute; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate inhibits or enhances induction of differentiation of mouse myeloid leukemia cells depending on the type of serum in the medium.
Topics: Animals; Cattle; Cell Differentiation; Cells, Cultured; Culture Media; Fetal Blood; Leukemia, Experimental; Leukemia, Myeloid; Mice; Phagocytes; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Tumor promoters cause a rapid and reversible inhibition of the formation and maintenance of electrical cell coupling in culture.
Topics: Cell Division; Cells, Cultured; Humans; Intercellular Junctions; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Analysis of phorbol ester receptors in phorbol ester unresponsive 3T3 cell variants.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cells, Cultured; Genetic Variation; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Tetradecanoylphorbol Acetate | 1981 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on alpha-aminoisobutyrate uptake in friend Erythroleukemic cells.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Clone Cells; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Membrane Potentials; Phorbols; Potassium; Sodium; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Colchicine; Drug Resistance; Genetic Variation; Mice; Mitogens; Phenotype; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1981 |
Decreased synthesis of high-molecular-weight glycopeptides in human promyelocytic leukemic cells (HL-60) during phorbol ester-induced macrophage differentiation.
Topics: Cell Adhesion; Cell Differentiation; Cell Line; Chromatography, DEAE-Cellulose; Chromatography, Gel; Glycopeptides; Granulocytes; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Macrophages; Membrane Proteins; Molecular Weight; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of phorbol myristate acetate and phytohemagglutinin stimulation of human lymphocytes by 13-cis-retinoic acid and ethyl etrinoate.
Topics: Etretinate; Humans; Isotretinoin; Lymphocyte Activation; Lymphocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1981 |
Expression of normal monocyte-macrophage differentiation antigens on HL60 promyelocytes undergoing differentiation induced by leukocyte-conditioned medium or phorbol diester.
Topics: Antigens, Surface; Cell Differentiation; Cell Line; Culture Media; Leukemia, Myeloid, Acute; Leukocytes; Macrophages; Monocytes; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Topics: Cells, Cultured; Glucose; Humans; Leukemia, Myeloid; Muramidase; Phagocytosis; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate | 1982 |
Resting state depth and saturation density as modulated by tumor promoters and culture conditions: relationship to chemical transformation in C3H/10T1/2 cells.
Topics: Animals; Carcinogens; Cell Count; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Mice; Mice, Inbred C3H; Phorbols; Saccharin; Tetradecanoylphorbol Acetate | 1982 |
Ganglioside changes induced by tumor promoters in promotable JB6 mouse epidermal cells: antagonism by an antipromoter.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epidermis; Gangliosides; Mice; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1982 |
Modification of growth and differentiation of myeloid leukemia cells by tumor promoters.
Topics: Animals; Blood; Cell Differentiation; Cell Line; Chromatography, Gel; Culture Media; Dinoprostone; Leukemia, Myeloid; Mice; Phagocytosis; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate | 1982 |
Cell differentiation, alterations in polyamine levels, and specific binding of phorbol diesters in cultured human cells.
Topics: Binding Sites; Carcinogens; Cell Differentiation; Cell Line; Cell Membrane; Humans; Leukemia, Myeloid, Acute; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Polyamines; Tetradecanoylphorbol Acetate | 1982 |
Generation of procoagulant activity (PCA) by phorbol-esters-induced macrophages derived from a leukemic promyelocytic cell line (HL-60).
Topics: Blood Coagulation Factors; Cell Differentiation; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Sialyltransferase activity as a marker for the differentiation of lymphocytes. Increase in sialyltransferase activity of blasts from acute lymphoblastic leukaemia cases by 12-o-tetradecanoylphorbol-13-acetate (TPA).
Topics: Cell Differentiation; Cells, Cultured; DNA Nucleotidylexotransferase; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Leukemia, Lymphoid; Lymphocytes; Phorbols; Sialyltransferases; Tetradecanoylphorbol Acetate; Time Factors; Transferases | 1982 |
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.
Topics: Animals; Cell Line; Gene Expression Regulation; Mice; Molecular Weight; Phorbols; Protein Biosynthesis; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Trifluoperazine | 1982 |
Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.
Topics: Cell Division; Cells, Cultured; Cholera Toxin; Humans; Melanocytes; Microscopy, Electron; Phorbols; Skin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1982 |
Some effects of the tumor promoter 12-0-tetradecanoylphorbol 13-acetate on cell interactions in vitro.
Topics: Animals; Cell Aggregation; Cell Differentiation; Cell Separation; Cells, Cultured; Chick Embryo; Dexamethasone; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryo, Nonmammalian; Phorbols; Retina; Tetradecanoylphorbol Acetate | 1982 |
Modulation of HeLa cell phospholipid metabolism and ornithine decarboxylase activity by tumour promoters: regulation of response to phorbol-12,13-dibutyrate by receptor occupancy time.
Topics: Caenorhabditis elegans Proteins; Carboxy-Lyases; Carrier Proteins; Enzyme Induction; HeLa Cells; Humans; Kinetics; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phospholipids; Protein Kinase C; Receptors, Drug; Tetradecanoylphorbol Acetate | 1982 |
Modification by serum of differentiation of cultured human myeloid leukemia cells in response to 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Blood Physiological Phenomena; Cells, Cultured; Culture Media; Humans; Leukemia, Experimental; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumor-promoter-resistant cells lack trisialoganglioside response.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Drug Resistance; Gangliosides; Membrane Fluidity; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Specific binding of phorbol esters to Friend erythroleukemia cells--general properties, down regulation and relationship to cell differentiation.
Topics: Animals; Binding Sites; Cell Differentiation; Diterpenes; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Inhibition by tumor-promoting phorbol esters of procollagen synthesis in promotable JB6 mouse epidermal cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Epidermis; Mice; Phorbol Esters; Phorbols; Procollagen; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Kinetics of appearance of differentiation-associated characteristics in ML-1, a line of human myeloblastic leukemia cells, after treatment with 12-O-tetradecanoylphorbol-13-acetate, dimethyl sulfoxide or 1-beta-D-arabinofuranosylcytosine.
Topics: Cell Cycle; Cell Differentiation; Cell Line; Cell Survival; Dimethyl Sulfoxide; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbols; Tetradecanoylphorbol Acetate; Vidarabine | 1982 |
Retinoids and phorbol esters alter release of fibronectin from enucleated cells.
Topics: Animals; Cell Membrane; Cell Nucleus; Cells, Cultured; Enzyme Induction; Fibronectins; Mice; Ornithine Decarboxylase; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Increase in histidine decarboxylase activity in skin of genetically mast-cell-deficient W/Wv mice after application of phorbol 12-myristate 13-acetate: evidence for the presence of histamine-producing cells without basophilic granules.
Topics: Animals; Bone Marrow; Carboxy-Lyases; Enzyme Induction; Histamine; Histidine Decarboxylase; Kinetics; Leukocytes; Mast Cells; Mice; Mice, Mutant Strains; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1982 |
Exposure to phorbol diester (TPA) in vitro as an aid in the classification of blasts in human myelogenous and lymphoid leukemias: in vitro differentiation, growth patterns, and ultrastructural observations.
Topics: Histocytochemistry; Humans; In Vitro Techniques; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.
Topics: Bloom Syndrome; Cells, Cultured; Cytoplasm; Humans; Isoelectric Point; Molecular Weight; Phorbols; Proteins; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1982 |
Induction of differentiation of human myeloid leukemias by phorbol diesters: phenotypic changes and mode of action.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Humans; Interphase; Leukemia, Experimental; Leukemia, Myeloid, Acute; Phenotype; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; Transferrin | 1982 |
Enhancement of growth of a mouse macrophage cell line by a tumor promoter and granulocyte-macrophage colony-stimulating factor.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Line; Colony-Stimulating Factors; Cricetinae; Culture Media; Growth Substances; Leukemia, Myeloid; Macrophages; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1980 |
Modulation of phagocytosis by tumor promoters and epidermal growth factor in normal and transformed macrophages.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Diterpenes; Epidermal Growth Factor; Erythrocytes; Female; In Vitro Techniques; Macrophages; Mice; Microscopy, Electron, Scanning; Peptides; Phagocytosis; Phorbols; Pyran Copolymer; Tetradecanoylphorbol Acetate; Thioglycolates | 1980 |
Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Monoiodotyrosine; Peptides; Phorbols; Protein Binding; Rats; Receptors, Drug; Temperature; Tetradecanoylphorbol Acetate | 1980 |
Growth arrest of AKR-2B cells maintained in the presence of epidermal growth factor or 12-O-tetradecanoylphorbol-13 acetate: evidence for two separate G1 arrest points.
Topics: Amanitins; Cell Line; Culture Media; DNA; Epidermal Growth Factor; Mitosis; Peptides; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Phorbol esters induce differentiation in human malignant T lymphoblasts.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; DNA Nucleotidylexotransferase; Humans; Leukemia, Experimental; Phorbol Esters; Phorbols; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1980 |
Retinoids block ornithine decarboxylase induction in cells treated with the tumor promotor TPA or the peptide growth hormones, EGF and SGF.
Topics: Animals; Carboxy-Lyases; Cell Line; Enzyme Induction; Epidermal Growth Factor; Growth Inhibitors; Kidney; Ornithine Decarboxylase; Phorbols; Rats; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1980 |
Human myelogenous leukemia: enhanced clonal proliferation in the presence of phorbol diesters.
Topics: Bone Marrow Cells; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Colony-Stimulating Factors; Humans; Leukemia, Myeloid; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
The tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces the production of lymphocyte-activating factors (LAP) in human lymphocyte cultures.
Topics: Cells, Cultured; Humans; Interleukin-2; Lymphocyte Activation; Lymphocytes; Lymphokines; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Tumor promoter modulation of epidermal growth factor- and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cells.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Line; Epidermal Growth Factor; Microvilli; Nerve Growth Factors; Peptides; Pheochromocytoma; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1980 |
Single or multicellular origin of human T lymphocyte colonies in vitro: modification by 12-o-tetradecanoylphorbol 13-acetate (TPA).
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Female; Glucosephosphate Dehydrogenase; Heterozygote; Humans; Peroxidases; Phorbols; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Variants of 3T3 cells lacking mitogenic response to the tumor promoter tetradecanoyl-phorbol-acetate.
Topics: Animals; Cell Count; Cell Line; Clone Cells; DNA Replication; Embryo, Mammalian; Epidermal Growth Factor; Genetic Variation; Mice; Mitogens; Mitosis; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Calmodulin inhibitors modify cell surface changes triggered by a tumor promoter.
Topics: Animals; Calcium-Binding Proteins; Calmodulin; Cell Line; Cell Membrane; Choline; Epidermal Growth Factor; Epidermis; HeLa Cells; Humans; Membrane Lipids; Mice; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate; Trifluoperazine | 1981 |
Regulation of myelopoiesis in vitro: partial replacement of colony-stimulating factors by tumor-promoting phorbol esters.
Topics: Animals; Bone Marrow Cells; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Glycoproteins; Hematopoiesis; Mice; Neoplasms; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Specific receptors for phorbol esters in lymphoid cell populations: role in enhanced production of T-cell growth factor.
Topics: Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Humans; Interleukin-2; Kinetics; Lymphokines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Structure-Activity Relationship; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Tumor promoting agent induces lymphocyte mitogenic factor.
Topics: DNA; Humans; Interleukin-2; Lymphokines; Mitosis; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Tumor promoter-induced inhibition of epidermal growth factor binding to cultured mouse primary epidermal cells.
Topics: Animals; Calcium; Cells, Cultured; Epidermal Growth Factor; Hyperplasia; Mice; Peptides; Phorbol Esters; Phorbols; Skin; Temperature; Tetradecanoylphorbol Acetate | 1981 |
Studies on T-lymphocyte activation. I. Is competence inductions in thymocytes by phorbol myristate acetate, an accessory cell-independent event?
Topics: Animals; Cells, Cultured; Concanavalin A; Immunocompetence; Lymphocyte Activation; Mice; Mice, Inbred C3H; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Growth stimulation of hamster embryonic fibroblasts by phorbol esters.
Topics: Animals; Cell Division; Cells, Cultured; Cricetinae; Culture Media; Deoxyglucose; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; Mesocricetus; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.
Topics: Antibody Formation; B-Lymphocytes; Cell Differentiation; Cell Division; Cell Line; Humans; Immunoglobulins; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Modification of normal human myelopoiesis by 12-0 tetradecanoylphorbol-13-acetate (TPA).
Topics: Bone Marrow Cells; Cell Differentiation; Colony-Forming Units Assay; Colony-Stimulating Factors; Culture Media; Drug Synergism; Hematopoiesis; Humans; Monocytes; Phorbols; Placenta; Tetradecanoylphorbol Acetate | 1981 |
Induction by tumor-promoting phorbol diester of colony-stimulating activity in human myeloid leukemia cells transformed to macrophage-mimicking cells.
Topics: Bone Marrow; Cell Adhesion; Cell Division; Cell Line; Colony-Stimulating Factors; Granulocytes; Humans; Leukemia; Leukemia, Myeloid; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Growth stimulation of microenvironment-dependent mouse leukemias by tumor-promoting phorbol esters.
Topics: Animals; Cell Communication; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Mice, Inbred AKR; Phorbol Esters; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1981 |
Induction of human malignant T-lymphoblastic cell lines MOLT-3 and jurkat by 12-O-tetradecanoylphorbol-13-acetate: biochemical, physical, and morphological characterization.
Topics: Cell Differentiation; Cell Division; Cell Line; Cytarabine; DNA Nucleotidylexotransferase; Humans; Lymphocyte Activation; Microscopy, Electron; Phorbols; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Promotion of x-ray transformation in vitro.
Topics: Animals; Anti-Inflammatory Agents; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA Repair; Epidermal Growth Factor; Mice; Mitomycins; Mutation; Phorbols; Radiation, Ionizing; Tetradecanoylphorbol Acetate; X-Rays | 1982 |
Regulation of growth and differentiation by phorbol esters and the mechanism of tumor promotion.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; Clone Cells; Colony-Stimulating Factors; Culture Media; Granulocytes; Humans; Leukemia, Myeloid; Macrophages; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Studies on antagonistic actions of TPA and retinoic acid.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Contact Inhibition; Epidermal Growth Factor; Mice; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Effects of tumor-promoting agents on cells of the murine immune system: inhibition of antibody synthesis and of macrophage-mediated tumor cell cytotoxicity.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cytotoxicity, Immunologic; Female; Macrophages; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Macrophage differentiation of human precursor B-cell line by phorbol ester and colony-stimulating factor.
Topics: B-Lymphocytes; Cell Adhesion; Cell Differentiation; Cell Line; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Humans; Macrophages; Naphthol AS D Esterase; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effects of 12-0-Tetradecanoylphorbol-13-acetate (TPA) on rat pheochromocytoma (PC12) cells: interactions with epidermal growth factor and nerve growth factor.
Topics: Animals; Cell Differentiation; Cell Line; Choline; Drug Interactions; Enzyme Induction; Epidermal Growth Factor; Nerve Growth Factors; Neurons; Ornithine Decarboxylase; Pheochromocytoma; Phorbols; Phosphates; Phosphorylation; Proteins; Rats; Tetradecanoylphorbol Acetate | 1982 |
A phorbol ester tumor promoter induces changes in the expression of immunoglobulins and DR antigens in human lymphoblastoid cells.
Topics: Antibody-Producing Cells; B-Lymphocytes; Cell Line; Cell Transformation, Neoplastic; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Immunoglobulin D; Immunoglobulin M; Immunoglobulins; Lymphocyte Activation; Phorbols; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1982 |
The effect of phorbol-myristate acetate and concanavalin A on the growth of interleukin-2-dependent T-cell lines.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Concanavalin A; Interleukin-2; Lymphocyte Activation; Lymphokines; Phorbols; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1982 |
Identification by monoclonal antibodies of T-cell subpopulations activated by 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Separation; Complement System Proteins; Humans; In Vitro Techniques; Lymphocyte Activation; Phorbols; Receptors, Fc; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Induction of differentiation in a case of common acute lymphoblastic leukemia.
Topics: Adult; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Humans; Immunoglobulins; Leukemia, Lymphoid; Male; Phenotype; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Phorbol-ester-mediated induction and augmentation of mitogenesis and interleukin-2 production in human T-cell lymphoproliferative disease.
Topics: Animals; Dose-Response Relationship, Immunologic; Humans; Interleukin-2; Leukemia, Lymphoid; Mice; Mitogens; Phorbols; Phytohemagglutinins; Rats; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Induction of differentiation in human T-lymphoblastic leukemia cell lines by 12-O-tetradecanoylphorbol 13-acetate (TPA): studies with monoclonal antibodies to T cells.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Cytarabine; DNA Replication; Humans; Leukemia, Lymphoid; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1982 |
Concomitant enhancement of B-cell mitogenesis and inhibition of antibody synthesis by a phorbol ester.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Lymphocyte Activation; Mice; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
The immunoglobulin production of human peripheral B lymphocytes induced by phorbol myristate acetate.
Topics: Antibody Formation; Antigens, Surface; B-Lymphocytes; Humans; Lymphocyte Cooperation; Monocytes; Phorbols; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1982 |
Human B-lymphocyte maturation sequence revealed by TPA-induced differentiation of leukaemic cells.
Topics: B-Lymphocytes; Cell Differentiation; Cells, Cultured; Humans; Leukemia, Lymphoid; Neoplasms, Experimental; Phorbols; Receptors, Immunologic; Rosette Formation; Tetradecanoylphorbol Acetate | 1982 |
Phytohemagglutinin inhibits phorbol diester promotion of UV-irradiation initiated transformation in Syrian hamster embryo cells.
Topics: Agglutinins; Animals; Cell Transformation, Neoplastic; Concanavalin A; Cricetinae; Galactose; Leukocytes; Lymphotoxin-alpha; Neoplasms, Radiation-Induced; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1982 |
Specific changes in the surface glycoprotein pattern of a human leukemic null cell line NALL-1 associated with morphologic and biological alterations induced by phorbol-ester.
Topics: Cell Division; Cell Line; Cell Membrane; DNA, Neoplasm; Fluorescent Antibody Technique; Glycoproteins; Humans; Kinetics; Leukemia; Membrane Proteins; Molecular Weight; Neoplasm Proteins; Phorbols; RNA, Neoplasm; Tetradecanoylphorbol Acetate | 1980 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the differentiation of avian melanocytes.
Topics: Animals; Birds; Cell Differentiation; Cells, Cultured; Epithelial Cells; Melanins; Melanocytes; Microscopy, Electron; Microscopy, Phase-Contrast; Neural Crest; Phorbols; Retinal Pigments; Tetradecanoylphorbol Acetate | 1980 |
Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.
Topics: Animals; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Skin Transplantation; Swine; Tetradecanoylphorbol Acetate; Transplantation Immunology; Transplantation, Heterologous | 1980 |
Selective effects of phorbol 12-myristate 13-acetate on myofibrils and 10-nm filaments.
Topics: Animals; Cell Transformation, Neoplastic; Chick Embryo; Fluorescent Antibody Technique; Microscopy, Fluorescence; Muscles; Myofibrils; Myosin Subfragments; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-accelerated phospholipid metabolism by 5,8,11,14-eicosatetraynoic acid.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Cattle; Choline; Epoprostenol; Fatty Acids, Unsaturated; Phorbols; Phospholipids; Prostaglandins; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate stimulates phagosome-lysosome fusion in mouse macrophages.
Topics: Animals; Cell Membrane; Cycloheximide; Dose-Response Relationship, Immunologic; Female; Fibroblasts; Indomethacin; Kinetics; Lymphoma, Large B-Cell, Diffuse; Lysosomes; Macrophages; Mice; Phorbols; Puromycin; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Differential response of premalignant epithelial cell classes to phorbol ester tumor promoters and to deoxycholic acid.
Topics: Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Deoxycholic Acid; DNA Replication; Epithelium; Humans; Peptide Hydrolases; Phorbols; Plasminogen Activators; Precancerous Conditions; Protease Inhibitors; Tetradecanoylphorbol Acetate | 1981 |
Effects of 12-O-tetradecanoyl-phorbol-13-acetate on Myofibril integrity and Ca2+ content in developing myotubes.
Topics: Animals; Calcium; Cells, Cultured; Chick Embryo; Fluorescent Antibody Technique; Microscopy, Electron; Muscles; Myofibrils; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Phorbol ester-induced differentiation of a non-T, non-B leukemic cell line: model for human lymphoid progenitor cell development.
Topics: Adolescent; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; DNA Nucleotidylexotransferase; Female; Fluorescent Antibody Technique; Histocompatibility Antigens Class II; Humans; Leukemia, Lymphoid; Lymphocytes; Phenotype; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of cellular division of a murine macrophage tumor by macrophage-activating agents.
Topics: Animals; Cell Division; Cell Line; Female; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Macrophages; Mice; Mice, Inbred Strains; Microscopy, Electron, Scanning; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumour-promoter-induced proliferation of 3T3 cells in independent of prostaglandin release and ornithine decarboxylase induction.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; Diamines; Dinoprostone; DNA; Enzyme Induction; Epoprostenol; Mice; Ornithine Decarboxylase; Phorbols; Prostaglandins; Prostaglandins E; Tetradecanoylphorbol Acetate | 1982 |
Suppression of natural tumor resistance by tumor promoters.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Lymphokines; Macrophage Activation; Macrophage-Activating Factors; Macrophages; Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1982 |
Hexose transport in undifferentiated and differentiated BALB/c 3T3 preadipose cells: effects 12-O-tetradecanoylphorbol-13-acetate and insulin.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport, Active; Cell Differentiation; Cells, Cultured; Deoxyglucose; Epidermal Growth Factor; Glucose; Insulin; Kinetics; Methylglucosides; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Prevention of tumor promoter-mediated inhibition of preadipocyte differentiation by dexamethasone.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cell Division; Clone Cells; Dexamethasone; Fibroblasts; Insulin; Mice; Mice, Inbred BALB C; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1981 |
Deacylation of 12-O-[3H]tetradecanoylphorbol-13-acetate and [3H]phorbol-12,13-didecanoate in hamster skin and hamster cells in culture.
Topics: Animals; Animals, Newborn; Carcinogens; Cell Line; Cells, Cultured; Cricetinae; Kinetics; Mesocricetus; Phorbol Esters; Phorbols; Radioisotope Dilution Technique; Skin; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Disappearance of nuclear TdT in RPMI-8402 following TPA treatment.
Topics: Adolescent; Cell Line; DNA Nucleotidylexotransferase; DNA Nucleotidyltransferases; DNA Replication; Female; Fluorescent Antibody Technique; Humans; Leukemia, Lymphoid; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate | 1982 |
Phorbol myristate acetate-induced adherence of Walker 256 carcinosarcoma cells.
Topics: Animals; Arachidonic Acids; Carcinoma 256, Walker; Cell Adhesion; Cell Aggregation; Cell Line; Colchicine; Cycloheximide; Cytochalasin B; Deoxyglucose; Humans; Mice; Phorbols; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 1982 |
Enhanced transformation of mouse 10T1/2 cells by 12-O-tetradecanoylphorbol-13-acetate following exposure to X-rays or to fission-spectrum neutrons.
Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Fast Neutrons; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Neutrons; Phorbols; Radiation Dosage; Tetradecanoylphorbol Acetate; X-Rays | 1982 |
Tumour-promoting diterpene esters prevent macrophage activation.
Topics: Animals; Carcinogens; Macrophage Activation; Mice; Mice, Inbred C3H; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1982 |
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on gamma radiation-induced DNA repair in resting bovine lymphocytes.
Topics: Animals; Cattle; Cells, Cultured; Centrifugation, Density Gradient; Dimethyl Sulfoxide; Diterpenes; DNA; DNA Repair; Gamma Rays; Interphase; Lymphocytes; Neoplasms; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Effects of tumor-promoting phorbol diesters on neoplastic progression of Syrian hamster embryo cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Mesocricetus; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Polyamines; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1982 |
Effects of retinoic acid and tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) on the cell cycle of HeLa cells.
Topics: Cell Cycle; Cell Division; Cell Transformation, Neoplastic; DNA; Drug Interactions; Flow Cytometry; HeLa Cells; Humans; Mitosis; Phorbols; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin | 1982 |
Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.
Topics: Animals; Cocarcinogenesis; Epidermis; Female; Hair; Humans; Hyperplasia; Methylcholanthrene; Mice; Phorbols; Precancerous Conditions; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.
Topics: Animals; Cell Line; Cells, Cultured; Embryo, Mammalian; Humans; Macaca mulatta; Phorbols; Retroviridae; Rhabdomyosarcoma; Tetradecanoylphorbol Acetate; Virus Activation; Virus Cultivation; Virus Diseases | 1982 |
Acute and progressive lung injury after contact with phorbol myristate acetate.
Topics: Acute Disease; Animals; Capillary Permeability; Catalase; Dose-Response Relationship, Drug; Lung; Lung Injury; Male; Muridae; Neutropenia; Phorbols; Pulmonary Alveoli; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Effect of macrophages on phorbol ester-stimulated comitogenesis in bovine lymphocytes.
Topics: Animals; Cattle; Cell Division; Cell Separation; Cells, Cultured; DNA; Drug Synergism; Lectins; Lymphocyte Activation; Lymphocytes; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.
Topics: Choline; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Humans; Phorbol Esters; Phorbols; Phosphatidylcholines; Phospholipases; Phospholipids; Phosphorylcholine; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
The role of mitogenic stimulation and specific glycoprotein changes in the mechanism of late-stage promotion in JB-6 epidermal cell lines.
Topics: Animals; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Epidermis; Mice; Mitogens; Phorbols; Procollagen; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Dynamics of phorbol diester promoters in epidermal cells in culture.
Topics: Animals; Carcinogens; Cells, Cultured; DNA; Epidermis; Kinetics; Mice; Mice, Inbred BALB C; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Genetic forms of neoplasia in man: a model for the study of tumor promotion in vitro.
Topics: Adenoma; Bile Acids and Salts; Cell Adhesion; Cell Cycle; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cocarcinogenesis; DNA; Dose-Response Relationship, Drug; Fibroblasts; Humans; Intestinal Neoplasms; Mutation; Phorbols; Skin; Tetradecanoylphorbol Acetate; Thymidine | 1982 |
Role of differentiation in determining responses of epidermal cells to phorbol esters.
Topics: Animals; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Induction; Epidermal Cells; Epidermis; Mice; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
The tumor promoter PMA reversibly inhibits chondrogenesis--influence on the expression of collagen types and fibronectin.
Topics: Animals; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; Collagen; Fibronectins; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Early changes in the cell cycle traverse of HeLa cells induced by tumor promoter TPA resemble irradiation effects.
Topics: DNA; HeLa Cells; Humans; Interphase; Kinetics; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Simple phorbol esters as inhibitors of tumor promotion by TPA in mouse skin.
Topics: Animals; Cocarcinogenesis; DNA; Dose-Response Relationship, Drug; Epidermis; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of intercellular communication by tumor promoters.
Topics: Animals; Carcinogens; Cell Communication; Cell Line; Diterpenes; Dose-Response Relationship, Drug; Hypoxanthine Phosphoribosyltransferase; Mice; Phorbol Esters; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
12-O-tetradecanoyl-phorbol-13-acetate and its relationship to SCE induction in Syrian and Chinese hamster cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cricetinae; Cricetulus; Crossing Over, Genetic; Mesocricetus; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays; X-Rays | 1982 |
Ca-calmodulin mediates the DNA-synthetic response of calcium-deprived liver cells to the tumor promoter TPA.
Topics: Calcium; Calcium-Binding Proteins; Calmodulin; Cell Division; Cells, Cultured; DNA Replication; Liver; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
TPA-induced inhibition of the expression of differentiative traits in cultured myotubes: dependence on protein synthesis.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Creatine Kinase; Cycloheximide; Kinetics; Muscles; Phorbols; Protein Biosynthesis; Receptors, Cholinergic; Tetradecanoylphorbol Acetate | 1982 |
Activation of monocyte and granulocyte antibody-dependent cytotoxicity by phorbol myristate acetate.
Topics: Antibody-Dependent Cell Cytotoxicity; Catalase; Cell Division; Cell Line; Dose-Response Relationship, Drug; Granulomatous Disease, Chronic; Hexosephosphates; Humans; Lymphocytes; Monocytes; Neutrophils; Oxygen; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Calcium movement and membrane potential changes in the early phase of neutrophil activation by phorbol myristate acetate: a study with ion-selective electrodes.
Topics: Animals; Calcium; Cattle; Cell Membrane; Electrodes; Kinetics; Membrane Potentials; Neutrophils; Oxygen Consumption; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.
Topics: Agranulocytosis; Animals; Free Radicals; Granulocytes; Granulomatous Disease, Chronic; Lung; Lung Injury; Mechlorethamine; Oxygen; Perfusion; Phorbols; Pulmonary Edema; Rabbits; Serum Albumin, Bovine; Sodium Chloride; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of beta-adrenergic stimulation of lymphocyte adenylate cyclase by phorbol myristate acetate is mediated by activated macrophages.
Topics: Adenylyl Cyclases; Animals; Catalase; Erythrocyte Membrane; Heme; Humans; Isoproterenol; Lymphocytes; Macrophages; Phorbols; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Turkeys | 1982 |
Enhancement of sister-chromatid exchanges by tumour promoters.
Topics: Animals; Cell Cycle; Cell Line; Crossing Over, Genetic; Deoxyglucose; Dose-Response Relationship, Drug; Neoplasms, Experimental; Phenobarbital; Phorbols; Saccharin; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate | 1982 |
Responses of amphibian embryos and blastomeres to a tumor-promoting phorbol ester.
Topics: Animals; Anura; Blastomeres; Cell Division; Cell Movement; Embryo, Nonmammalian; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effect of retinoic acid pretreatment on 12-O-tetradecanoylphorbol-13-acetate-induced cell population kinetics and polyamine biosynthesis in hairless mouse epidermis.
Topics: Adenosylmethionine Decarboxylase; Animals; DNA; Female; Kinetics; Male; Metaphase; Mice; Mice, Hairless; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1982 |
Decreased incidence of gap junctions between Chinese hamster V-79 cells upon exposure to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Animals; Cell Communication; Cell Membrane; Cells, Cultured; Cricetinae; Cricetulus; Freeze Fracturing; Intercellular Junctions; Microscopy, Electron; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumor-promoting phorbol esters and mezerien induce contraction in hydra.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diterpenes; Hydra; Phorbol Esters; Phorbols; Structure-Activity Relationship; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
Topics: Animals; Blood Platelets; Blood Proteins; Brain; Calcium; Enzyme Activation; Kinetics; Phorbols; Phospholipids; Phosphorylation; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of respiration by a phorbol ester tumor promoter in murine cultured cells.
Topics: Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line; Cell Transformation, Neoplastic; Embryo, Mammalian; Fibroblasts; Methylcholanthrene; Mice; Mice, Inbred C3H; Oligomycins; Oxygen Consumption; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Must initiators come first? Tumorigenic and carcinogenic effects on skin of 3-methylcholanthrene and TPA in various sequences.
Topics: Animals; Carcinoma; Cell Division; DNA; Drug Synergism; Hyperplasia; Methylcholanthrene; Mice; Mice, Hairless; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Effects of 12-O-tetradecanoylphorbol 13-acetate on glycerolipid metabolism in cultured myoblasts.
Topics: Animals; Calcium; Cells, Cultured; Chick Embryo; Cycloheximide; Diglycerides; Fatty Acids; Glycerides; Membrane Lipids; Muscles; Phorbols; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Tetradecanoylphorbol Acetate | 1982 |
PMA-induced biosynthetic changes in differentiating muscle cells in culture.
Topics: Cell Differentiation; Cells, Cultured; Muscle Proteins; Muscles; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Induction of monocyte-macrophage differentiation in a new diploid line of human hematopoietic cells (CM-S) by phorbol esters.
Topics: Anemia; Bone Marrow; Cell Differentiation; Cell Division; Cell Line; Diploidy; Hematopoietic Stem Cells; Humans; Kinetics; Macrophages; Monocytes; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Suppression of the cytotoxic response of mouse lymphocytes to syngeneic tumor cells by tumor-promoting phorbol ester.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Female; Killer Cells, Natural; Lymphoma; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multiple Myeloma; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Unique cell surface glycoprotein expression in hairy cell leukemia: effect of phorbol ester tumor promoters on surface glycoproteins, cell morphology, and adherence.
Topics: Adult; Aged; Cell Adhesion; Cells, Cultured; Female; Glycoproteins; Humans; Leukemia; Leukemia, Hairy Cell; Male; Membrane Proteins; Middle Aged; Neoplasm Proteins; Phorbol Esters; Phorbols; Primary Myelofibrosis; Tetradecanoylphorbol Acetate | 1982 |
Contact-stimulated proliferation of cultured mouse epidermal cells by 3T3 feeder layers: inhibition of proliferation by 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Animals; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Embryo, Mammalian; Humans; Mice; Mice, Inbred BALB C; Phorbols; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Effect of phorbol esters on guniea pig skin in vivo.
Topics: Animals; Cell Division; Dermatitis, Contact; DNA; Epidermis; Female; Guinea Pigs; Indomethacin; Ornithine Decarboxylase; Phorbols; Prostaglandins; Skin; Tetradecanoylphorbol Acetate | 1982 |
Inhibition by 12-O-tetradecanoylphorbol-13-acetate of 17 beta-estradiol-induced initiation of DNA synthesis in rabbit endometrial cells in culture.
Topics: Animals; Cells, Cultured; DNA; Endometrium; Estradiol; Female; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1982 |
Increased fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in the phorbol myristate acetate-stimulated plasma membrane of human neutrophils.
Topics: Cell Membrane; Diphenylhexatriene; Fluorescence Polarization; Humans; In Vitro Techniques; Membrane Lipids; Neutrophils; Phorbols; Polyenes; Tetradecanoylphorbol Acetate | 1982 |
Early alteration induced by tumor promoters on chick embryo muscle cells in culture.
Topics: Actins; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Muscle Proteins; Muscles; Myosins; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Subcellular localization of hydrogen peroxide production in human polymorphonuclear leukocytes stimulated with lectins, phorbol myristate acetate, and digitonin: an electron microscopic study using CeCl3.
Topics: Cell Communication; Cerium; Cytochalasin B; Cytoplasmic Granules; Digitonin; Hydrogen Peroxide; Lectins; Microscopy, Electron; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate; Vacuoles | 1982 |
Nerve growth factor-induced neuronal differentiation of PC12 pheochromocytoma cells: lack of inhibition by a tumor promoter.
Topics: Animals; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Nerve Growth Factors; Nerve Regeneration; Pheochromocytoma; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1982 |
Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.
Topics: Adult; Aged; Aging; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Mitogens; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Failure of phorbol ester TPA to promote growth of in vivo-initiated rat hepatocytes transferred into a culture system.
Topics: Animals; Cell Division; Cells, Cultured; Liver; Male; Phenobarbital; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoters specifically and reversibly disturb development and behavior of Caenorhabditis elegans.
Topics: Animals; Caenorhabditis; Carcinogens; Movement; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effect of the tumor promotor 12-O-tetradecanoylphorbol-13-acetate on the rate of disappearance of nicotine from mouse skin.
Topics: Administration, Topical; Animals; Benzopyrenes; Female; Half-Life; Kinetics; Mice; Mice, Inbred ICR; Nicotine; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1982 |
Tumor promoter-mediated effects on Friend leukemia cells induced by actinomycin D: flow microfluorometry analysis and erythroid differentiation.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Line; Dactinomycin; Flow Cytometry; Leukemia, Experimental; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effects of phorbol ester tumor promoters and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells.
Topics: Animals; Axons; Cell Division; Cell Line; Chick Embryo; Ganglia, Sympathetic; Humans; Nerve Growth Factors; Neuroblastoma; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Disrupted communication between late-stage premalignant human colon epithelial cells by 12-O tetradecanoylphorbol-13-acetate.
Topics: Adenoma; Cell Communication; Cells, Cultured; Colonic Neoplasms; Epithelium; Humans; Phorbols; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1982 |
Tumor-promoting phorbol esters induce macrophage differentiation from bone marrow precursors.
Topics: Animals; Bone Marrow; Cell Adhesion; Cell Differentiation; DNA Replication; Immunoglobulin Fc Fragments; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Muramidase; Phagocytosis; Phorbols; Rats; Rats, Inbred Strains; Rosette Formation; Tetradecanoylphorbol Acetate | 1982 |
Are all normal diploid human cell strains alike? Relevance to carcinogenic mechanisms in vitro.
Topics: Adenocarcinoma; Cell Division; Cells, Cultured; Colonic Neoplasms; Diploidy; Embryo, Mammalian; Female; Fibroblasts; Humans; Kinetics; Male; Phorbols; Pregnancy; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.
Topics: Animals; Calcium; Cell Line; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Phospholipids; Protein Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms | 1982 |
Effects of phorbol ester tumor promoters and hyperplasiogenic agents on cytoplasmic glucocorticoid receptors in epidermis.
Topics: Alkynes; Animals; Carcinogens; Dexamethasone; Diterpenes; Epidermis; Female; Male; Mice; Phorbol Esters; Phorbols; Receptors, Glucocorticoid; Receptors, Steroid; Temperature; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
The release of granule components from human polymorphonuclear leukocytes in response to both phagocytic and chemical stimuli.
Topics: Blood Proteins; Cell Fractionation; Cytoplasmic Granules; Humans; Neutrophils; Phagocytosis; Phorbols; Tetradecanoylphorbol Acetate; Transcobalamins | 1982 |
Measurement of the response of HELA cells towards the radiomimetic activity of 12-O-tetradecanoylphorbol-13-acetate.
Topics: Acetone; Cell Cycle; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Interphase; Mitosis; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Animals; Arachidonic Acids; Biotransformation; Female; Male; Mice; Neoplasms, Experimental; Oxygenases; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandin Antagonists; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Failure of phorbol myristate acetate to damage DNA in leukocytes from patients with chronic granulomatous disease.
Topics: DNA; Granulomatous Disease, Chronic; Humans; Leukocytes; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.
Topics: Cations; Cells, Cultured; Colchicine; Complement C3b; Cycloheximide; Erythrocytes; Humans; Monocytes; Phagocytosis; Phorbol Esters; Phorbols; Podophyllotoxin; Receptors, Complement; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Protein synthesis and degradation in cultured muscle is altered by a phorbol diester tumor promoter.
Topics: Animals; Cells, Cultured; Chick Embryo; DNA; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Muscle Proteins; Muscles; Phorbols; Protein Biosynthesis; Proteins; Tetradecanoylphorbol Acetate | 1982 |
Biological effects of phorbol ester tumor promoters in mouse skin.
Topics: Animals; Cell Division; Hyperplasia; Kinetics; Mice; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
An immunological study of cartilage differentiation in cultures of chick limb bud cells: influence of a tumor promoter (TPA) on chondrogenesis and on extracellular matrix formation.
Topics: Animals; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; Extracellular Space; Extremities; Fibronectins; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Effects of cell surface receptor-altering agents on the binding and biological activity of 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells.
Topics: alpha-L-Fucosidase; Animals; Atropine; Binding Sites; Binding, Competitive; Carboxy-Lyases; Cell Membrane; Cholera Toxin; G(M1) Ganglioside; Galactose Oxidase; Kinetics; Mice; Neuraminidase; Ornithine Decarboxylase; Phentolamine; Phorbols; Phospholipases; Propranolol; Skin; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Formation of a glucuronide conjugate of 12-O-tetradecanoylphorbol-13-acetate by LLC-PK1 renal epithelial cells in culture.
Topics: Animals; Cattle; Cell Line; Dogs; Glucuronates; Glucuronidase; Kidney; Kinetics; Phorbols; Species Specificity; Swine; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Glycopeptide alterations induced by 12-O-tetradecanoyl phorbol-13-acetate in chick embryo cultured myotubes.
Topics: Animals; Cells, Cultured; Chick Embryo; Chromatography, Affinity; Glycopeptides; Muscles; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
The effect of phorbols on metabolic cooperation between human fibroblasts.
Topics: Autoradiography; Cell Communication; Cell Line; Fibroblasts; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Mutation; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Induction of human autorosette forming cells by phorbol myristate acetate.
Topics: Humans; Lymphocyte Activation; Lymphocytes; Monocytes; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate | 1982 |
[Cocarcinogen as a factor increasing the incidence of mutation responsible for cellular resistance to antifolates].
Topics: Animals; Cell Survival; Cells, Cultured; Cocarcinogenesis; Drug Resistance; Genes; Humans; Methotrexate; Mice; Mutation; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1982 |
Tumor-promoting phorbol diesters inhibit in vitro antibody synthesis.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Cell Differentiation; Cell Division; Cells, Cultured; Erythrocytes; Mice; Phorbol Esters; Phorbols; Sheep; Spleen; Tetradecanoylphorbol Acetate | 1980 |
Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate.
Topics: Animals; Biological Transport; Cells, Cultured; Chick Embryo; Deoxyglucose; Diterpenes; Dose-Response Relationship, Drug; Fibronectins; Inflammation; Mice; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1980 |
Tumor promoter induces loss of anchorage dependence in human skin fibroblasts from individuals genetically predisposed to cancer.
Topics: Adenoma; Agar; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; Fibroblasts; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Phorbols; Rectal Neoplasms; Skin; Tetradecanoylphorbol Acetate | 1980 |
Suppression of lectin-stimulated DNA synthesis in bovine lymphocytes by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cattle; Cells, Cultured; Depression, Chemical; DNA; Dose-Response Relationship, Drug; Lectins; Lymphocytes; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Alterations in lipid metabolism induced by 12-O-tetradecanoylphorbol-13-acetate in differentiating human myeloid leukemia cells.
Topics: Animals; Cell Differentiation; Cell Membrane; Cells, Cultured; Diglycerides; Humans; Leukemia, Experimental; Lipid Metabolism; Neoplasm Proteins; Phorbols; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Tetradecanoylphorbol Acetate; Triglycerides | 1980 |
Lack of correlation between effects of tumor promoter TPA on plasminogen activator production, phosphatidyl choline synthesis, and hexose transport in mammalian cell culture systems.
Topics: Animals; Biological Transport, Active; Cell Line; Cells, Cultured; Choline; Cricetinae; Cricetulus; Female; HeLa Cells; Hexoses; Humans; Kidney; Leukemia, Experimental; Lymphocytes; Mice; Mice, Inbred BALB C; Ovary; Phorbols; Phosphatidylcholines; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1980 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on two charateristics of transformation acquired sequentially by ENU-exposed rat brain cells.
Topics: Agar; Animals; Brain; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Ethylnitrosourea; Phorbols; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate induced neutrophil autotoxicity.
Topics: Cell Aggregation; Cell Line; Cell Survival; Female; Humans; Hydrogen Peroxide; Multiple Myeloma; Neutrophils; Ovarian Neoplasms; Oxygen; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Induction of plasminogen activator and prostaglandin biosynthesis in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Dogs; Enzyme Induction; HeLa Cells; Humans; Indomethacin; Kidney; Phorbols; Plasminogen Activators; Prostaglandins; Tetradecanoylphorbol Acetate | 1980 |
Tumor promoter-induced changes in the permeability of epithelial cell tight junctions.
Topics: Animals; Cells, Cultured; Cycloheximide; Cytoskeleton; Dogs; Epithelium; Intercellular Junctions; Microtubules; Permeability; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1981 |
Induction of macrophage DNA synthesis by phorbol esters.
Topics: Animals; Ascitic Fluid; DNA; Dose-Response Relationship, Drug; Macrophages; Mice; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1981 |
Dexamethasone inhibition and phorbol myristate acetate stimulation of plasminogen activator in human embryonic lung cells.
Topics: Cell Line; Dexamethasone; Female; Fibrinolysis; Humans; Kinetics; Lung; Phorbols; Plasminogen Activators; Pregnancy; Subcellular Fractions; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1981 |
Tumor cell killing by phorbol ester--differentiated human leukemia cells.
Topics: Animals; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Leukemia, Experimental; Macrophages; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight.
Topics: Animals; Cell Line; Cell Membrane; Intracellular Membranes; Mice; Molecular Weight; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Antagonism of concanavalin A capping in phorbol ester-activated lymphocytes by calmodulin inhibitors and certain amino acid esters.
Topics: Amino Acids; Animals; Calcium-Binding Proteins; Calmodulin; Cattle; Concanavalin A; Cytochalasin B; Cytochalasin D; Cytochalasins; Cytoskeleton; Esters; Kinetics; Lymphocytes; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
12-O-tetradecanoylphorbol-13-acetate (TPA) induces sister-chromatid exchanges and delays in cell progression in Chinese hamster ovary and human cell lines.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Line; Chromosomes; Cricetinae; Cricetulus; Crossing Over, Genetic; DNA; Dose-Response Relationship, Drug; Female; Humans; Ovary; Phorbols; Sister Chromatid Exchange; Skin; Tetradecanoylphorbol Acetate | 1982 |
Metabolic cooperation in CHO and V79 cells following treatment with a tumor promoter.
Topics: Animals; Cell Membrane; Cells, Cultured; Cricetinae; Phorbols; Tetradecanoylphorbol Acetate; Thioguanine | 1981 |
Induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13 acetate in rat tissues.
Topics: Animals; Brain; Carboxy-Lyases; Enzyme Induction; Hypophysectomy; Kinetics; Liver; Lung; Male; Organ Specificity; Ornithine Decarboxylase; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1980 |
The tumor promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) increases glyoxalase I and decreases glyoxalase II activity in human polymorphonuclear leukocytes.
Topics: Humans; Lactoylglutathione Lyase; Lyases; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate; Thiolester Hydrolases | 1981 |
Cell culture tumor promotion experiments with saccharin, phorbol myristate acetate and several common food materials.
Topics: Animals; Ascorbic Acid; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Pantothenic Acid; Phorbols; Saccharin; Tetradecanoylphorbol Acetate; Tryptophan | 1980 |
Inhibition by zinc of hepatic lysosomal release of beta-glucuronidase induced by phorbol-12-myristate-13-acetate (PMA).
Topics: Animals; Cricetinae; Glucuronidase; Liver; Lysosomes; Male; Mesocricetus; Phorbols; Tetradecanoylphorbol Acetate; Zinc | 1980 |
Effects of tumor promoters and extracellular calcium on the growth of normal, transformed and temperature sensitive rat liver epithelial cells.
Topics: Animals; Calcium; Cell Line; Cell Transformation, Neoplastic; Epithelium; Liver; Mutation; Phorbols; Rats; Temperature; Tetradecanoylphorbol Acetate | 1980 |
Binding of phorbol-12-myristate-13-acetate to cultured myoblasts.
Topics: Animals; Binding Sites; Blood Proteins; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Kinetics; Muscles; Phorbols; Protein Binding; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate | 1980 |
Analysis of developmentally homogeneous neural crest cell populations in vitro. II. A tumor-promoter (TPA) delays differentiation and promotes cell proliferation.
Topics: Animals; Cell Differentiation; Cell Division; DNA; Embryo, Nonmammalian; Kinetics; Neural Crest; Phorbols; Quail; Tetradecanoylphorbol Acetate | 1981 |
Inhibition of metabolic cooperation in Chinese hamster cells by various chemical including tumor promoters.
Topics: Animals; Carcinogens; Cell Membrane; Cells, Cultured; Cricetinae; Cricetulus; Phorbols; Tetradecanoylphorbol Acetate; Thioguanine | 1980 |
Direct measurement of specific binding of highly lipophilic phorbol diester to mouse epidermal membranes using cold acetone.
Topics: Acetone; Animals; Binding Sites; Cell Membrane; Female; Kinetics; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Tritium | 1981 |
Induction of mouse hepatic ornithine decarboxylase by skin application of 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carboxy-Lyases; Dose-Response Relationship, Drug; Enzyme Induction; Female; Liver; Mice; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Arachidonic acid and prostaglandin E2 release and enhanced cell proliferation induced by the phorbol ester TPA in a murine epidermal cell line.
Topics: Animals; Arachidonic Acids; Cell Division; Cell Line; Mice; Phorbols; Prostaglandins E; Skin; Tetradecanoylphorbol Acetate | 1981 |
Surface-reactive stimuli selectively increase protein phosphorylation in human neutrophils.
Topics: Adult; Chemotaxis, Leukocyte; Electrophoresis, Polyacrylamide Gel; Humans; Methionine; Molecular Weight; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phorbols; Phosphates; Phosphorylation; Tetradecanoylphorbol Acetate | 1981 |
The effect of the tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on UV- and MNNG-induced sister chromatid exchanges in mammalian cells.
Topics: Animals; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Methylnitronitrosoguanidine; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1980 |
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis.
Topics: Animals; Calcium; Carboxy-Lyases; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media; Enzyme Induction; Epidermal Cells; Epidermis; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1981 |
The effect of phorbol esters on the proliferation of C3H-10T 1/2 mouse fibroblasts: consideration of both stimulatory and inhibitory effects.
Topics: Animals; Cell Division; Culture Media; Depression, Chemical; Fibroblasts; Kinetics; Mice; Phorbol Esters; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1981 |
Light emission by isolated rat glomeruli in response to phorbol myristate acetate.
Topics: Animals; Antimycin A; Catalase; Dose-Response Relationship, Drug; Ethylmaleimide; Iodoacetamide; Kidney Glomerulus; Leukocytes; Luminescent Measurements; Oxygen; Phorbols; Rats; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Antipain and 12-O-tetradecanoyl-phorbol-13-acetate: phenomenology of effects on UV mutagenesis in V79 Chinese hamster cells.
Topics: Animals; Antipain; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Repair; Drug Interactions; Fibroblasts; Mutagens; Oligopeptides; Phorbols; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1980 |
Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate.
Topics: Animals; Carboxy-Lyases; Histidine; Histidine Decarboxylase; Kinetics; Male; Methylhistidines; Mice; Mice, Inbred C57BL; Ornithine; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1981 |
12-O-Tetradecanoylphorbol-13-acetate induced alterations in mouse epidermal 3-hydroxy-3-methylglutaryl CoA reductase.
Topics: Animals; Female; Hydroxymethylglutaryl CoA Reductases; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
The molecular structure and charge distribution of phorbol: parent compound of the tumor promoting phorbol diesters.
Topics: Chemical Phenomena; Chemistry; Computers; Models, Molecular; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Thermodynamics | 1981 |
Effect of butyric acid on tumor promotion: a correction.
Topics: Animals; Butyrates; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Interaction between latent papovavirus genomes and the tumor promoter TPA.
Topics: Cell Transformation, Viral; DNA, Viral; Papillomaviridae; Phorbols; Plasmids; Polyomaviridae; Tetradecanoylphorbol Acetate; Virus Replication | 1981 |
The use of a tumor promoter as a single parameter approach for the detection of individuals genetically predisposed to colorectal cancer.
Topics: Cell Division; Cells, Cultured; Colonic Neoplasms; Female; Fibroblasts; Humans; Male; Phorbols; Rectal Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Phorbol related esters have similar structure-activity relations in Swiss 3T3 cells and chicken embryo fibroblasts.
Topics: Animals; Cells, Cultured; Chick Embryo; Deoxyglucose; Diterpenes; Fibroblasts; Mice; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Investigation of the effects of the phorbol ester TPA on carcinogen-induced forward mutagenesis to 6-thioguanine-resistance in V79 Chinese hamster cells.
Topics: Animals; Carcinogens; Cells, Cultured; Cricetinae; Drug Resistance; Female; Mutation; Phorbols; Tetradecanoylphorbol Acetate; Thioguanine | 1981 |
Changes in epidermal polyamine biosynthesis and specific activity of DNA following a single application of 12-O-tetradecanoyl-phorbol-13-acetate to hairless mouse skin.
Topics: Adenosylmethionine Decarboxylase; Animals; DNA; Kinetics; Mice; Mice, Nude; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Tetradecanoylphorbol Acetate | 1981 |
Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cells, Cultured; Colony-Forming Units Assay; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Fibroblasts; Mice; Mice, Inbred C3H; Ovary; Phorbols; Sister Chromatid Exchange; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1981 |
31 P NMR spectroscopy of phorbol-myristate-acetate stimulated polymorphonuclear human leukocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; NAD; NADP; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion.
Topics: Animals; Cell Count; Cell Division; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplification; Methotrexate; Mice; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1981 |
Enhancement of carcinogenesis in cultured respiratory tract epithelium by 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epithelium; Female; Methylnitronitrosoguanidine; Neoplasms, Experimental; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors; Trachea; Tracheal Neoplasms | 1980 |
Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arginase; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
The effect of non-phorbol promoters as compared with phorbol myristate acetate on sister chromatid exchange induction in cultured Chinese hamster cells.
Topics: Animals; Anthralin; Cantharidin; Carcinogens; Cells, Cultured; Cricetinae; Cricetulus; Crossing Over, Genetic; Iodoacetates; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate | 1981 |
Phorbol ester-induced anchorage independence and its antagonism by retinoic acid correlates with altered expression of specific glycoproteins.
Topics: Animals; Carcinogens; Cell Adhesion; Cells, Cultured; Gene Expression Regulation; Glycoproteins; Mice; Neoplasms, Experimental; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Cell population kinetics in hairless mouse epidermis following a single topical application of 12-O-tetradecanoylphorbol-13-acetate I.
Topics: Administration, Topical; Animals; Carcinogens; Cell Division; DNA; Female; Kinetics; Male; Mice; Mice, Hairless; Mitosis; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Effect of tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate on induction of sister-chromatid exchanges in Chinese hamster V79 cells treated with mutagens.
Topics: Animals; Cell Line; Chromatids; Cricetinae; Cricetulus; Crossing Over, Genetic; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lung; Mitomycins; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate | 1981 |
Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin.
Topics: Abrin; Animals; Cell Line; Cell Survival; Chlorocebus aethiops; Diphtheria Toxin; HeLa Cells; Humans; L Cells; Lectins; Phorbols; Plant Lectins; Protein Biosynthesis; Rats; Ribosome Inactivating Proteins, Type 2; Ricin; Tetradecanoylphorbol Acetate; Toxins, Biological; Tretinoin | 1981 |
Dissociation of tumour-promoter-induced effects on prostaglandin release, polyamine synthesis and cell proliferation of 3T3 cells.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; DNA; Enzyme Induction; Fibroblasts; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Prostaglandins; Tetradecanoylphorbol Acetate; Thymidine | 1981 |
Generation of 1,2-diacylglycerol in plasma membranes of phorbol ester-treated myoblasts.
Topics: Animals; Cell Differentiation; Cell Membrane; Chick Embryo; Diglycerides; Glycerides; Kinetics; Muscles; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Initiation of C3H/10T1/2 cell transformation by formaldehyde.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Formates; Methanol; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Enhancement of macrophage-induced cytotoxicity by phorbol ester tumor promoters.
Topics: Animals; Cell Line; Cell Survival; Cytotoxicity, Immunologic; Leukemia L5178; Leukemia, Experimental; Macrophages; Male; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Tumor-promoting phorbol diester-induced specific changes in cell surface glycoprotein profile of K562 human leukemic cells.
Topics: Cell Count; Cell Differentiation; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Glycophorins; Glycoproteins; Humans; Leukemia; Membrane Proteins; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Fatty acid metabolism in phorbol ester-differentiating human leukemia cells.
Topics: Carcinogens; Cell Differentiation; Cell Line; Fatty Acids; Humans; Leukemia; Lipid Metabolism; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
[3H] thymidine incorporation in bovine lymphocytes treated with the tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Animals; Cattle; Cells, Cultured; Deoxycytidine; DNA; Lymph Nodes; Lymphocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1981 |
Phorbol ester-mediated modulation of cell proliferation and primary differentiation of mouse preimplantation embryos.
Topics: Animals; Blastocyst; Cell Differentiation; Cell Division; Culture Techniques; DNA; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Differentiation modulates the response of guinea pig epidermal keratinocytes to the stimulation of DNA synthesis by TPA.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA; Epidermal Cells; Epidermis; Female; Guinea Pigs; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Cell Division; Cell Line; Cells, Cultured; Cytoplasmic Granules; Epinephrine; Humans; In Vitro Techniques; Microscopy, Electron; Neuroblastoma; Norepinephrine; Phenotype; Phorbols; Phosphopyruvate Hydratase; Tetradecanoylphorbol Acetate | 1981 |
The induction of ornithine decarboxylase by tumor promoting phorbol ester analogues in Reuber H35 hepatoma cells.
Topics: Animals; Carboxy-Lyases; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Polyamines; Rats; Tetradecanoylphorbol Acetate | 1981 |
Parallel activities of fatty acid methyl esters and analogous phorbol diesters toward mouse lymphocytes.
Topics: Animals; Esters; Fatty Acids; Female; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbols; Phytohemagglutinins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Inhibition of replicon initiation by 12-O-tetradecanoylphorbol-13-acetate.
Topics: DNA Replication; HeLa Cells; Humans; Kinetics; Phorbols; Replicon; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1981 |
Specific binding of the tumor promoter TPA in various mouse organs as measured by a "cold acetone-filter assay'.
Topics: Animals; Binding, Competitive; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Female; Kidney; Kinetics; Liver; Lung; Mice; Mice, Inbred Strains; Organ Specificity; Ovary; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Spleen; Tetradecanoylphorbol Acetate; Thymus Gland | 1981 |
Induction of rat hepatic ornithine decarboxylase by the tumor promotors 12-O-tetradecanoylphorbol-13-acetate and phenobarbital in vivo; effect of retinyl-acetate.
Topics: Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Diterpenes; Enzyme Induction; Female; Kinetics; Liver; Ornithine Decarboxylase; Phenobarbital; Phorbols; Rats; Retinyl Esters; Tetradecanoylphorbol Acetate; Vitamin A | 1981 |
The time needed for normalization of hairless mouse epidermis after treatment with twice weekly topical skin applications of 10 nmol 12-O-tetradecanoylphorbol-13-acetate in acetone, or acetone alone, for 18 weeks. A morphologic and cell kinetic study.
Topics: Acetone; Animals; Cell Cycle; Female; Hyperplasia; Kinetics; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiator and promoter induced specific changes in epidermal function and biological potential.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Induction; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbols; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1981 |
Rapid alteration in Ca++ content and fluxes in phorbol 12-myristate 13-acetate treated myoblasts.
Topics: Animals; Biological Transport; Calcium; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Kinetics; Muscles; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous activities in vivo.
Topics: Animals; Cells, Cultured; Chick Embryo; Deoxy Sugars; Deoxyglucose; Fibroblasts; Fibronectins; Inflammation; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Activity of phorbol ester tumor promoters on enucleated Swiss 3T3 cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Fibroblasts; Mice; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Binding of [3H]12-O-tetradecanoylphorbol-13-acetate to intact human peripheral blood lymphocytes.
Topics: Adult; Humans; In Vitro Techniques; Kinetics; Lymphocyte Activation; Lymphocytes; Phorbols; Receptors, Drug; Tetradecanoylphorbol Acetate; Thymidine; Vitamin A | 1980 |
Epidermal growth following a single application of 12-O-tetradecanoyl-phorbol-13-acetate in mice.
Topics: Administration, Topical; Animals; DNA; Epidermal Cells; Epidermis; Female; Hyperplasia; Mice; Mitosis; Organ Size; Phorbols; Proteins; Regeneration; Tetradecanoylphorbol Acetate | 1980 |
An in vitro model of pancreas carcinogenesis: two-stage MNU--TPA effect.
Topics: Animals; Cell Transformation, Neoplastic; Hyperplasia; Methylnitrosourea; Mice; Mice, Nude; Models, Biological; Necrosis; Neoplasm Transplantation; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Pancreatic Neoplasms; Phorbols; Rats; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1980 |
Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA.
Topics: Animals; Cell Division; Female; Indomethacin; Kinetics; Mice; Phorbols; Prostaglandins E; Skin; Skin Physiological Phenomena; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Effect of time and duration of exposure to 12-O-tetradecanoylphorbol-13-acetate on x-ray transformation of C3H 10T 1/2 cells.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Mice; Phorbols; Tetradecanoylphorbol Acetate; Time Factors; X-Rays | 1980 |
Early inhibition of thymidine uptake and stimulation of cell proliferation in rat embryo fibroblasts treated with tumor-promoting 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Enzyme Induction; Fibroblasts; Ornithine Decarboxylase; Phorbols; Phosphates; Rats; Tetradecanoylphorbol Acetate; Thymidine; Thymine Nucleotides | 1980 |
Chemical inducers of differentiation in Friend leukaemia cells inhibit lymphocyte mitogenesis.
Topics: Animals; Butyrates; Cell Differentiation; Cell Line; Cell Survival; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Leukemia, Experimental; Lymphocyte Activation; Membrane Fluidity; Mice; Mitogens; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Prostaglandin enhancement of skin tumor initiation and promotion.
Topics: Animals; Indomethacin; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
The interaction of [3H]TPA with bovine lymph node lymphocytes in vitro.
Topics: Animals; Biological Transport; Cells, Cultured; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Effects of a tumor promoter and an anti-promoter on spontaneous and UV-induced 6-thioguanine-resistant mutations and sister-chromatid exchanges in V79 Chinese hamster cells.
Topics: Animals; Antipain; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Mutation; Oligopeptides; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Thioguanine; Ultraviolet Rays | 1980 |
Inhibition of induced murine erythroleukemia cell differentiation by tumor promoters: relation to the cell cycle.
Topics: Acetamides; Animals; Cell Cycle; Cell Differentiation; Diamines; DNA, Neoplasm; Globins; Kinetics; Leukemia, Experimental; Mice; Phorbols; RNA, Messenger; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages.
Topics: Animals; Ascitic Fluid; Cell Movement; Colchicine; Cytochalasins; Endocytosis; Horseradish Peroxidase; Macrophages; Mice; Phorbols; Pinocytosis; Podophyllotoxin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
Regulation of polyamine biosynthesis in normal and transformed hamster cells in culture.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Enzyme Induction; Fibroblasts; Ornithine Decarboxylase; Phorbols; Polyamines; Putrescine; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1980 |
An organ culture of adult mouse skin: an in vitro model for studying the molecular mechanism of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; DNA; Enzyme Induction; Female; Indomethacin; Mice; Models, Biological; Neoplasms, Experimental; Organ Culture Techniques; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Indomethacin enhancement of TPA tumor promotion in mice.
Topics: Animals; Drug Synergism; Female; Flurbiprofen; Indomethacin; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism.
Topics: Animals; Arginine Vasopressin; Biological Transport, Active; Cell Line; Deoxyglucose; DNA; Mice; Mitogens; Ornithine Decarboxylase; Phorbols; Receptors, Drug; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells.
Topics: Cell Differentiation; Cells, Cultured; Clone Cells; Cytoplasm; Humans; Leukemia, Lymphoid; Phorbols; Plasma Cells; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate | 1980 |
Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells.
Topics: Cell Cycle; DNA Replication; HeLa Cells; Humans; Interphase; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; X-Rays | 1980 |
Long-term effect of a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, on induced differentiation of Friend leukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cells, Cultured; Cocarcinogenesis; Diamines; Friend murine leukemia virus; Leukemia, Experimental; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Virus Diseases | 1980 |
Differences in the metabolism of 12-O-[3H]tetradecanoylphorbol-13-acetate and [3H]phorbol-12,13-didecanoate by cells in culture.
Topics: Adipose Tissue; Animals; Cells, Cultured; Chick Embryo; Cricetinae; Epidermis; Humans; Liver Neoplasms, Experimental; Mice; Phorbol Esters; Phorbols; Species Specificity; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Calcium; Cell Cycle; Cells, Cultured; Cocarcinogenesis; DNA; Liver; Phenobarbital; Phorbol Esters; Phorbols; Rats; Saccharin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on the morphology and growth of C3H/10T1/2 mouse embryo cells.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Embryo, Mammalian; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Inhibition of the adipose conversion of BALB/c 3T3 cells by 12-O-tetradecanoylphorbol-13-acetate: dependence on pH reduction via lactic acid production.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cell Line; Culture Media; Depression, Chemical; Fibroblasts; Hydrogen-Ion Concentration; Kidney; Lactates; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate: in vivo effects upon neutrophils, platelets, and lung.
Topics: Animals; Blood Platelets; Capillary Permeability; Cell Aggregation; Female; Humans; Lung; Neutropenia; Neutrophils; Phorbols; Pulmonary Circulation; Rabbits; Respiration; Serum Albumin, Radio-Iodinated; Tetradecanoylphorbol Acetate; Thrombocytopenia | 1980 |
Early effects of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate on the cell cycle traverse of asynchronous HeLa cells.
Topics: Cell Cycle; Dimethyl Sulfoxide; DNA, Neoplasm; HeLa Cells; Humans; Mitosis; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Responses of synchronized HeLa cells to the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate as evaluated by flow cytometry.
Topics: Cell Cycle; DNA, Neoplasm; HeLa Cells; Humans; Methotrexate; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Hyperplasia of Syrian hamster epidermis induced by single but not multiple treatments with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Hyperplasia; Male; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; DNA Replication; Enzyme Induction; Epidermal Cells; Mice; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Ultraviolet Rays | 1981 |
Inhibition of terminal differentiation of hamster epidermal cells in culture by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cricetinae; Epidermal Cells; Epidermis; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids.
Topics: Animals; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Cricetinae; Crossing Over, Genetic; Mice; Phorbols; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Tumour promoter induces proliferation of 3T6 cells in serum-free medium, as do polypeptide growth factors.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media; Drug Synergism; Growth Substances; Mice; Phorbols; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1980 |
A comparison of phorbol myristate acetate with phytohemgglutinin as a stimulator of in vitro colony growth of peripheral human leucocytes.
Topics: Cell Division; Cells, Cultured; Granulocytes; Humans; Leukocytes; Monocytes; Phorbols; Phytohemagglutinins; Tetradecanoylphorbol Acetate | 1980 |
Phorbol myristate acetate-induced neutrophil autotoxicity. A comparison with H2O2 toxicity.
Topics: Azides; Catalase; Chromium Radioisotopes; Cytotoxicity, Immunologic; Humans; Hydrogen Peroxide; In Vitro Techniques; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Enhancement of recovery of chemical carcinogen-induced ouabain-resistant mutants in Chinese hamster cells by the tumor-promoting agent, 12-o-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Gene Frequency; Lung; Mutation; Ouabain; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Inhibition by putrescine of the induction of epidermal ornithine decarboxylase activity and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cocarcinogenesis; Enzyme Induction; Epidermis; Mice; Ornithine Decarboxylase; Phorbols; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Tumor-promoting phorbol esters affect production of prolactin and growth hormone by rat pituitary cells.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Cobalt; Growth Hormone; Kinetics; Phorbol Esters; Phorbols; Pituitary Gland; Prolactin; Rats; Tetradecanoylphorbol Acetate | 1981 |
Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells.
Topics: Adenylyl Cyclases; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Ethers, Cyclic; Glioma; GTP-Binding Proteins; Hybrid Cells; Naphthalenes; Neuroblastoma; Okadaic Acid; Phorbols; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Ganglia, Sympathetic; Isoquinolines; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Phorbol Esters; Phorbols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rana catesbeiana; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1994 |
[Secretion of peptide YY and truncated glucagon-like peptide 1 by isolated intestinal cells in rats].
Topics: Adult; Animals; Calcium-Transporting ATPases; Chromatography, Affinity; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Ionomycin; Male; Peptide Fragments; Peptide YY; Peptides; Phorbols; Protein Precursors; Rats; Rats, Wistar; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Protein kinase C second messenger system mediates the antisteroidogenic effects of prostaglandin F2 alpha in the ovine corpus luteum in vivo.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Cholesterol Side-Chain Cleavage Enzyme; Corpus Luteum; Dinoprost; Enzyme Activation; Female; Phorbols; Progesterone; Protein Kinase C; RNA, Messenger; Second Messenger Systems; Sheep; Tetradecanoylphorbol Acetate | 1994 |
Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats.
Topics: Alkaloids; Animals; Enzyme Activation; Fasting; Food; Hemodynamics; In Vitro Techniques; Liver; Liver Circulation; Male; Organ Size; Perfusion; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Monoclonal antibody 8A2-induced retraction appears to be mediated by protein phosphorylation in goldfish retinal ganglion cell axons.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Axons; Calcium; Cyclic AMP; Ethers, Cyclic; Goldfish; Nerve Regeneration; Okadaic Acid; Organ Culture Techniques; Phorbol Esters; Phorbols; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Retinal Ganglion Cells; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation.
Topics: Animals; GTP-Binding Proteins; Inositol Phosphates; Male; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phorbols; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Restoration of the transient outward potassium current by noradrenaline in chagasic canine epicardium.
Topics: Animals; Chagas Disease; Dogs; Heart; In Vitro Techniques; Indoles; Isoproterenol; Maleimides; Membrane Potentials; Mice; Mice, Inbred A; Neomycin; Norepinephrine; Patch-Clamp Techniques; Pericardium; Pertussis Toxin; Phorbols; Potassium Channels; Prazosin; Reference Values; Second Messenger Systems; Tetradecanoylphorbol Acetate; Trypanosoma cruzi; Virulence Factors, Bordetella | 1997 |
Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor.
Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Calcium Channels; Cannabinoids; Carcinogens; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Hormone Antagonists; Indoles; Maleimides; Morpholines; Mutagenesis; Naphthalenes; omega-Conotoxin GVIA; Peptides; Phorbols; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Serine; Signal Transduction; Somatostatin; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells.
Topics: Adenosine Triphosphate; Animals; Bacterial Proteins; Calcium; Cell Line; Cell Membrane Permeability; Cytoplasmic Granules; Enzyme Activation; Exocytosis; Kinetics; Mucins; Mucous Membrane; Phorbols; Protein Kinase C; Rats; Streptolysins; Tetradecanoylphorbol Acetate; Trachea; Uridine Triphosphate | 1998 |
Mechanisms involved in desensitization of particulate guanylyl cyclase in human airway smooth muscle: the role of protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Humans; Indoles; Maleimides; Muscle, Smooth; Phorbols; Phosphodiesterase Inhibitors; Protein Kinase C; Respiratory System; Solubility; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
Topics: Antigens, CD; CD28 Antigens; Cell Adhesion Molecules; Cells, Cultured; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Jurkat Cells; Kinetics; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Vanadates | 2000 |
Functional differences between splice variants of the murine 5-HT(3A) receptor: possible role for phosphorylation.
Topics: Alternative Splicing; Cell Line; Cyclic AMP; Cyclic GMP; Genetic Variation; Humans; Membrane Potentials; Patch-Clamp Techniques; Phorbols; Phosphorylation; Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A.
Topics: Amides; Animals; Blotting, Western; Calcium; Cattle; Cells, Cultured; Chelating Agents; Ciliary Body; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Phorbols; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Tetradecanoylphorbol Acetate; Trabecular Meshwork | 2000 |
Activation of protein kinase C increases acetylcholine release from frog motor nerves by a direct action on L-type Ca(2+) channels and apparently not by depolarisation of the terminal.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Enzyme Inhibitors; Motor Neurons; Naphthalenes; Neuromuscular Junction; Nimodipine; Phorbols; Potassium Chloride; Presynaptic Terminals; Protein Kinase C; Rana temporaria; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2001 |
Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport System X-AG; Animals; Carcinogens; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Indoles; Maleimides; Membrane Potentials; Oocytes; Phorbols; Protein Kinase C; RNA, Complementary; Symporters; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured; Xenopus laevis | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC.
Topics: Blotting, Western; Cells, Cultured; Cilia; Dose-Response Relationship, Drug; Humans; Indicators and Reagents; Nasal Mucosa; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 2002 |
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
Topics: Alkaloids; Animals; Benzophenanthridines; Clozapine; Drug Interactions; Electric Stimulation; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fluorobenzenes; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Peptide Fragments; Phenanthridines; Phorbols; Piperidines; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Endocannabinoids; Endotoxemia; Lipopolysaccharides; Male; Mesentery; Norepinephrine; Phorbols; Polyunsaturated Alkamides; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tongue; TRPV Cation Channels; Vasoconstrictor Agents; Vasodilation | 2007 |
Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Forkhead Box Protein O1; Forkhead Transcription Factors; G1 Phase; Humans; Isoenzymes; Mitogen-Activated Protein Kinases; Phorbols; Phosphorylation; Protein Kinase C-delta; Protein Transport; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; S Phase; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transfection | 2008 |
Phorbol 12-myristate 13-acetate stimulation under hypoxia induces nuclear swelling with DNA outflow but not extracellular trap formation of neutrophils.
Topics: Acetates; DNA; Extracellular Traps; Histones; Humans; Hypoxia; Lung Diseases; Myristic Acid; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 2022 |
Bioinformatics of Differentially Expressed Genes in Phorbol 12-Myristate 13-Acetate-Induced Megakaryocytic Differentiation of K562 Cells by Microarray Analysis.
Topics: Acetates; Cell Differentiation; Computational Biology; Humans; K562 Cells; Megakaryocytes; Microarray Analysis; Myristic Acid; Phorbols; Tetradecanoylphorbol Acetate; Thrombopoiesis | 2022 |