phorbols and phorbol
phorbols has been researched along with phorbol in 127 studies
Compound Research Comparison
| Studies (phorbols) | Trials (phorbols) | Recent Studies (post-2010) (phorbols) | Studies (phorbol) | Trials (phorbol) | Recent Studies (post-2010) (phorbol) |
|---|---|---|---|---|---|
| 2,217 | 0 | 72 | 135 | 0 | 22 |
Research
Studies (127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (37.01) | 18.7374 |
| 1990's | 36 (28.35) | 18.2507 |
| 2000's | 25 (19.69) | 29.6817 |
| 2010's | 14 (11.02) | 24.3611 |
| 2020's | 5 (3.94) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Paradiso, AM | 1 |
| Bosca, L; Cascales, M; Martin-Sanz, P | 1 |
| Andrews, PE; Montgomery, BT; Tindall, DJ; Young, CY | 1 |
| Byrne, JH; Critz, SD | 1 |
| Raufman, JP | 1 |
| Calixto, JB; Guimarães, CL; Rae, GA | 1 |
| Gross, JL; Horuk, R | 1 |
| Sacktor, TC; Schwartz, JH | 1 |
| Alterman, RL; Kornblith, PL; Maleci, A; Moskal, JR; Sundstrom, D | 1 |
| Brown, BL; Dobson, PR; Quilliam, LA | 1 |
| Field, JB; Nielsen, TB; Rani, CS; Tanabe, A | 1 |
| Burton, DW; Deftos, LJ; Murray, SS | 1 |
| Choi, EJ; Toscano, WA | 1 |
| Hogans, BB; Spivak, JL; Stuart, RK | 1 |
| Brown, BL; Dobson, PR; Evans, DB; Russell, RG | 1 |
| Hoshi, T; Shimada, T | 1 |
| Hirata, Y | 1 |
| Chuang, DM; Dillon-Carter, O | 1 |
| Morgan, EH; Sorokin, LM; Yeoh, GC | 1 |
| Insel, PA; Slivka, SR | 1 |
| Entwistle, A; Farzaneh, F; Zalin, RJ | 1 |
| Bauer, KD; Dunn, MM; Kamp, DW; Rubin, DB | 1 |
| de Graan, PN; Eichberg, J; Gispen, WH; Schrama, LH | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Drummond, AH; MacIntyre, DE; McNicol, A | 1 |
| Brown, JH; Orellana, SA; Solski, PA | 1 |
| Civan, MM; Mauro, T; O'Brien, TG; Rubenstein, D | 1 |
| Carr, BR; Mason, JI; Rainey, WE | 1 |
| el-Fakahany, EE; Lai, WS | 2 |
| Blenis, J; Erikson, RL | 1 |
| Boyd, AW; Forsgren, A; Nadler, LM; Schlossman, SF; Tedder, TF | 1 |
| Amir, S | 1 |
| Kuramoto, A; Matsui, I; Morisawa, S; Otani, S | 1 |
| Craven, PA; DeRubertis, FR; Patterson, MC | 1 |
| Bayard, F; Darbon, JM; Valette, A | 1 |
| Murphy, RL; Smith, ME | 1 |
| Chobanian, MC; Hammerman, MR | 1 |
| Jung, CY; Martz, A; Mookerjee, BK | 1 |
| Kojo, S; Tsukamoto, I | 1 |
| Finlay, TH; Kadner, SS; Katz, J; Levitz, M | 1 |
| Cohen, A; Mellors, A; Stalmach, ME | 1 |
| Lefkowitz, RJ; Nambi, P; Sibley, DR | 1 |
| de Haas, CG; Vaartjes, WJ | 1 |
| Cooke, E; Hallett, MB | 1 |
| Baird, AW; Evans, FJ; Pearce, JB; Williamson, EM | 1 |
| Adelstein, RS; Hidaka, H; Nishikawa, M; Sellers, JR | 1 |
| Nomura, S; Oishi, M; Shobu, N | 1 |
| Peterfreund, RA; Vale, WW | 1 |
| Bishop, R; Martinez, R; Nakamura, KD; Weber, MJ | 1 |
| Kuwata, T; Morinaga, N | 1 |
| Janowsky, A; Labarca, R; Patel, J; Paul, SM | 1 |
| Kuroda, Y; Mikami, H | 1 |
| Park, CH | 1 |
| Bash, JA; Baxter, CS; Ferguson, TA; Fish, LA; Michael, JG | 1 |
| Bols, NC; Mosser, DD | 1 |
| Malbon, CC; Strassheim, D | 1 |
| Chen, H; Jassar, BS; Kurenny, DE; Smith, PA | 1 |
| Abello, J; Bosshard, A; Chayvialle, JA; Saifia, S | 1 |
| Juengel, JL; McGuire, WJ; Niswender, GD | 1 |
| Araki, M; Inaba, H; Numai, T | 1 |
| Bandres, JC; Ratner, L | 1 |
| Black, SC; Chi, L; Fagbemi, SO; Friedrichs, GS; Lucchesi, BR | 1 |
| Ichikawa, K; Ito, M; Itoh, H; Konishi, T; Nakano, T; Okubo, S; Shimomura, A | 1 |
| Finnegan, SG; Koenig, E; Lemmon, VP | 1 |
| Ashby, CR; Edwards, E; Wang, RY | 1 |
| Frindt, G; Palmer, LG; Windhager, EE | 1 |
| Aten, RF; Behrman, HR; Preston, SL; Rinaudo, P; Zreik, TG | 1 |
| Barr, SC; Gilmour, RF; Han, W; Pacioretty, LM | 1 |
| Hirsh, JK; Redman, RS; Searl, TJ; Silinsky, EM | 1 |
| Hirono, M; Suzuki, N; Takagi, H; Yoshioka, T | 1 |
| Colbert, CM; Johnston, D | 1 |
| Brown, S; Garcia, DE; Hille, B; Mackie, K | 1 |
| Abdullah, LH; Davis, CW; Scott, CE | 1 |
| Agosti, SJ; Gallatin, WM; Hakala, S; Hoffman, P; Rabb, H; Ramirez, G | 1 |
| Camerino, C; Conte Camerino, D; De Luca, A; Liantonio, A; Pierno, S | 1 |
| Bhagavan, S; Etcheberrigaray, R; Ibarreta, D; Kozikowski, AP; Ma, D | 1 |
| Kim, YH; Koh, JY; Noh, KM | 1 |
| Conn, PJ; Macek, TA; Schaffhauser, H | 1 |
| Gomes, R; Sampaio-Maia, B; Soares-da-Silva, P | 1 |
| Hamad, AM; Knox, AJ | 1 |
| Amara, SG; Daniels, GM | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Hubbard, PC; Lummis, SC; Thompson, AJ | 1 |
| Nass, JU; Nuskovski, M; Pleyer, U; Strauss, O; Thieme, H; Wiederholt, M | 1 |
| Khan, N; McDonald, RL; Peers, C; Roberts, DJ; Vaughan, PF; Webster, NJ | 1 |
| Cha, JK; Lee, K | 1 |
| Arenson, MS; Evans, SC | 1 |
| Barak, D; Rein, R; Shibata, M | 1 |
| Dunlop, J; Hediger, MA; Peng, JB; Trotti, D | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Cubillos, S; Guerra, A; Lima, L | 1 |
| Benham, CD; Cairns, W; Davis, JB; Droogmans, G; Flockerzi, V; Hayes, P; Jerman, JC; Nilius, B; Prenen, J; Smart, D; Smith, GD; Vriens, J; Watanabe, H; Wissenbach, U | 1 |
| Abdel-Hafez, AA; Hattori, M; Nakamura, N | 1 |
| Green, M; Mehta, A; Muimo, R; Mwimbi, XK; Sijumbila, G; Treharne, KJ | 1 |
| Hall, D; Hursthouse, MB; Malik, A; Marson, CM; Pink, JH; Smith, C | 1 |
| Berghman, LR; Byrd, JA; Caldwell, DJ; Caldwell, DY; Hargis, BM; McElroy, AP; Moore, RW | 1 |
| Jardemark, KE; Liang, X; Ninan, I; Wang, RY | 1 |
| Franklin, RA; Howe, CJ; LaHair, MM; McCubrey, JA; Robinson, PJ; Rodriguez-Mora, O | 1 |
| Blakely, RD; Jayanthi, LD; Ramamoorthy, S; Samuvel, DJ | 1 |
| Kakegawa, W; Kondo, T; Yuzaki, M | 1 |
| Harada, N; Kubo, N; Liu, B; Mizuno, A; Shen, J; Suzuki, M; Yamashita, T | 1 |
| Das, UN; Rao, KP | 1 |
| Abramoff, T; Adler-Graschinsky, E; Neuman, I; Orliac, ML; Peroni, RN; Podesta, EJ | 1 |
| Brueggemeier, RW; Díaz-Cruz, ES; Landini, S; Su, B | 1 |
| Kee, JM; Warrington, JM; Wender, PA | 1 |
| Afrasiabi, E; Ahlgren, J; Bergelin, N; Törnquist, K | 1 |
| DeSimone, JA; Lyall, V; Mahavadi, S; Melone, P; Mummalaneni, S; Murthy, KS; Phan, TH | 1 |
| Elsässer, A; Hamm, CW; Kostin, S; Möllmann, H; Nef, H; Rolf, A; Schaper, W; Schilp, A; Schmitz-Rixen, T; Szardien, S; Troidl, C; Troidl, K; Voss, S | 1 |
| Fulton, DJ; Pandey, D | 1 |
| Chen, L; Chen, RM; Han, J; Hong, L; Hu, WY; Liao, R; Sun, P; Xu, Z; Yoshizuka, N; Yu, G | 1 |
| Li, JY; Qi, HY; Shi, YP; Wang, R | 1 |
| Chang, HT; Chen, IL; Chou, CT; Huang, JK; Jan, CR; Kuo, DH; Liang, WZ; Shieh, P | 1 |
| Bader, A; Braca, A; Giner, RM; Martini, F; Prieto, JM; Ríos, JL; Schinella, GR | 1 |
| Kerubo, LO; Langat, MK; Midiwo, JO; Ndunda, B; Wanjohi, JM | 1 |
| Aki, N; Funaki, M; Hata, A; Nishimura, M; Oyadomari, S; Shikama, Y | 1 |
| Blumberg, PM; Keck, GE; Kedei, N; Kraft, MB; Lewin, NE; Peach, ML; Poudel, YB | 1 |
| Baran, PS; Chu, H; Felding, J; Kawamura, S | 1 |
| Hanada, Y; Horii, A; Imai, T; Inohara, H; Ishida, Y; Kamakura, T; Kitahara, T; Kondo, M; Koyama, Y; Nakamura, Y; Ozono, Y; Shimada, S; Takimoto, Y; Yamada, T | 1 |
| Daigo, Y; Sumimoto, H; Takano, A; Teramoto, K | 1 |
| Barnard, RJ; Blair, W; Hazuda, D; Howell, BJ; Maxwell, JW; Nefedov, A; Newhard, W; Sanchez, RI; Steve, J; Tellers, D; Vemula, SV; Wan, BL; Webber, AL | 1 |
| Alabdul Magid, A; Benmerache, A; Hubert, J; Kabouche, A; Kabouche, Z; Labed, A; Morjani, H; Voutquenne-Nazabadioko, L | 1 |
| Behm, DJ; Brnardic, EJ; Lawhorn, BG | 1 |
| Ishibashi, M; Ishizu, A; Kato, K; Masuda, S; Nakazawa, D; Nishibata, Y; Sugimoto, A; Tanaka, S; Tomaru, U; Tsujino, I | 1 |
| Kim, JE; Lee, SH; Park, NR | 1 |
| Chen, HP; Fan, JP; Gao, Y; He, BT; Peng, HL; Xie, CF | 1 |
| Barnes, AB; Judge, PT; Overall, SA | 1 |
Reviews
1 review(s) available for phorbols and phorbol
| Article | Year |
|---|---|
Recent advances in TRPV4 agonists and antagonists.
Topics: Biological Products; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Phorbols; TRPV Cation Channels | 2020 |
Other Studies
126 other study(ies) available for phorbols and phorbol
| Article | Year |
|---|---|
Identification of Na(+)-H+ exchange in human normal and cystic fibrotic ciliated airway epithelium.
Topics: Adolescent; Adult; Amiloride; Carrier Proteins; Cells, Cultured; Cilia; Cystic Fibrosis; Epithelium; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Nasal Mucosa; Nasal Polyps; Phorbols; Potassium; Reference Values; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1992 |
Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes.
Topics: Animals; Bombesin; Cells, Cultured; Cycloheximide; Female; Fetus; Insulin; Kinetics; Liver; Male; Phorbols; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Pregnancy; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Topics: Alkaloids; Antigens, Neoplasm; Biomarkers, Tumor; Calcimycin; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Humans; Male; Nandrolone; Phorbols; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Staurosporine; Testosterone Congeners; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of IK,Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Ganglia; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
Topics: Animals; Calcimycin; Calmodulin; Carbachol; Cholera Toxin; Gastric Mucosa; Guinea Pigs; Imidazoles; In Vitro Techniques; Kinetics; Male; Phorbol 12,13-Dibutyrate; Phorbols; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate | 1992 |
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents | 1992 |
Protein kinase C-linked inactivation of the interleukin-1 receptor in a human transformed B-cell line.
Topics: B-Lymphocytes; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Cell Membrane; Enzyme Activation; Humans; Interleukin-1; Kinetics; Lymphoma; Phorbol 12,13-Dibutyrate; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Receptors, Interleukin-1; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.
Topics: Animals; Aplysia; Caenorhabditis elegans Proteins; Carrier Proteins; Cyclic AMP; Ganglia; Histones; In Vitro Techniques; Magnesium; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Phorbols; Phosphorylation; Protein Kinase C; Receptors, Drug; Serotonin; Subcellular Fractions; Thionucleotides | 1990 |
Effect of phorbol esters on the susceptibility of a glioma cell line to lymphokine-activated killer cell activity.
Topics: Cell Division; Glioma; Humans; Killer Cells, Lymphokine-Activated; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1990 |
Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Cell Line; Cholera Toxin; Cyclic AMP; GTP-Binding Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pituitary Gland; Pituitary Neoplasms; Rats; Thyrotropin-Releasing Hormone; Time Factors; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1985 |
Thyroid cell responses to thyrotropin and 12-O-tetradecanoyl-phorbol-13-acetate: translocation of protein kinase C and phosphorylation of thyroid cell polypeptide substrates.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Peptides; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors | 1985 |
The coregulation of secretion and cytoplasmic ribonucleic acid of chromogranin-A and calcitonin by phorbol ester in cells that produce both substances.
Topics: Calcitonin; Cell Line; Chromogranin A; Chromogranins; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Nerve Tissue Proteins; Nucleic Acid Hybridization; Phorbol Esters; Phorbols; RNA; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1988 |
Modulation of adenylate cyclase in human keratinocytes by protein kinase C.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Line; Epidermis; Humans; Isoproterenol; Keratins; Pertussis Toxin; Phorbol Esters; Phorbols; Propranolol; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colony-Forming Units Assay; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Erythropoietin; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cells; Indomethacin; Interleukin-3; Isoquinolines; Mice; Phorbols; Piperazines; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Agents affecting adenylate cyclase activity modulate the stimulatory action of 1,25-dihydroxyvitamin D3 on the production of osteocalcin by human bone cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaline Phosphatase; Bone and Bones; Bucladesine; Calcitriol; Cells, Cultured; Colforsin; Humans; Interleukin-1; Kinetics; Osteoblasts; Osteocalcin; Phorbols; Recombinant Proteins; Theophylline | 1989 |
Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter.
Topics: Amiloride; Animals; Bucladesine; Calcimycin; Carrier Proteins; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Hydrogen-Ion Concentration; Jejunum; Male; Microvilli; Phorbol Esters; Phorbols; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Theophylline | 1988 |
Heterologous down-regulation of vascular atrial natriuretic peptide receptors by phorbol esters.
Topics: Animals; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells.
Topics: Animals; Bradykinin; Cell Line; Diphenhydramine; GTP-Binding Proteins; Kinetics; Lithium; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylinositols; Triprolidine; Type C Phospholipases | 1988 |
Differences in transferrin receptor function between normal developing and transformed myogenic cells as revealed by differential effects of phorbol ester on receptor distribution and rates of iron uptake.
Topics: Animals; Avian Sarcoma Viruses; Biological Transport; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Conalbumin; DNA Replication; Iron; Kinetics; Muscles; Phorbols; Receptors, Transferrin; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C.
Topics: Animals; Arachidonic Acids; Bradykinin; Calcimycin; Cell Line; Dogs; Enzyme Activation; Hydrolysis; Kidney; Kinetics; Neomycin; Phorbols; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Protein kinase C mediates the hormonally regulated plasma membrane fusion of avian embryonic skeletal muscle.
Topics: Alprostadil; Animals; Cell Fusion; Cells, Cultured; Chick Embryo; Diglycerides; DNA; Enzyme Activation; Indomethacin; Muscles; Myosins; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Tumor-promoting phorbol esters inhibit monocyte adherence to endothelial cells.
Topics: Animals; Aorta; Carcinogens; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Male; Monocytes; Phorbol 12,13-Dibutyrate; Phorbols; Tetradecanoylphorbol Acetate | 1989 |
Dioctanoylglycerol and phorbol diesters enhance phosphorylation of phosphoprotein B-50 in native synaptic plasma membranes.
Topics: Animals; Calcium; Diglycerides; Dose-Response Relationship, Drug; GAP-43 Protein; Glycerides; Histones; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Synaptic Membranes | 1986 |
Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Diglycerides; Enzyme Activation; Isradipine; Mice; Neural Crest; Oxadiazoles; Phorbol Esters; Phorbols; Potassium; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets.
Topics: Blood Platelets; Calcium; Carcinogens; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylinositols; Platelet Activating Factor; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Thrombin; Vasopressins | 1985 |
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Humans; Hydrolysis; Phorbol Esters; Phorbols; Phosphatidylinositols; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1985 |
Effects of tumor promoters on sodium ion transport across frog skin.
Topics: Amiloride; Animals; Biological Transport, Active; Carcinogens; Cyclic AMP; Indomethacin; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rana pipiens; Skin; Sodium; Tetradecanoylphorbol Acetate | 1985 |
The action of phorbol ester on steroidogenesis in cultured human fetal adrenal cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Bucladesine; Cells, Cultured; Cyclic AMP; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diglycerides; Humans; Hydrocortisone; Phorbol Esters; Phorbols; Protein Kinase C; Steroid Hydroxylases; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1987 |
Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.
Topics: Animals; Blood Physiological Phenomena; Chick Embryo; Cycloheximide; Enzyme Activation; Fibroblasts; Glucose; Oncogene Protein pp60(v-src); Phorbols; Phosphorylation; Protein Kinase C; Retroviridae Proteins; Ribosomal Protein S6; Ribosomal Proteins; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1986 |
Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Antigens, Surface; Calcium; Cell Cycle; Cell Differentiation; Cell Division; Histocompatibility Antigens Class II; Lymphocyte Activation; Phorbols; Time Factors | 1986 |
TPA (12-O-tetradecanoylphorbol-13-acetate) enhances the central hypoglycemic action of thyrotropin-releasing hormone in mice.
Topics: Animals; Blood Glucose; Brain; Dose-Response Relationship, Drug; Hypoglycemia; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Induction of ornithine decarboxylase in guinea-pig lymphocytes. Synergistic effect of diacylglycerol and calcium.
Topics: Animals; Calcimycin; Calcium; Calmodulin; Cells, Cultured; Cytosol; Diglycerides; Enzyme Induction; Glycerides; Guinea Pigs; Lymphocytes; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Phytohemagglutinins; Protein Kinase C; Protein Kinases; Type C Phospholipases | 1985 |
Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Dinoprostone; Female; Isoquinolines; Kidney Glomerulus; Phorbol Esters; Phorbols; Piperazines; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function.
Topics: Animals; Binding Sites; Carbachol; Clone Cells; Enzyme Activation; Kinetics; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Muscarinic | 1988 |
Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C.
Topics: Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Effects of diacylglycerol and phorbol ester on acetylcholine release and action at the neuromuscular junction in mice.
Topics: Animals; Benzylamines; Calcium; Diaphragm; Diglycerides; Electric Stimulation; Glycerides; In Vitro Techniques; Magnesium; Membrane Potentials; Mice; Motor Endplate; Neuromuscular Junction; Pargyline; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phrenic Nerve; Stereoisomerism; Tubocurarine | 1987 |
Phorbol esters inhibit ammoniagenesis and gluconeogenesis in proximal tubular segments.
Topics: Ammonia; Animals; Dimethyl Sulfoxide; Dogs; Gluconeogenesis; Glutamine; Kidney Tubules, Proximal; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1987 |
Insulin and phorbol esters affect the maximum velocity rather than the half-saturation constant of 3-O-methylglucose transport in rat adipocytes.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Insulin; Kinetics; Male; Methylglucosides; Methylglycosides; Monosaccharide Transport Proteins; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Effect of phorbol ester on rat liver regeneration.
Topics: Animals; Cell Division; DNA Replication; Liver; Liver Regeneration; Phorbols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1987 |
The 65-kDa phorbol-diester hydrolase in mouse plasma is esterase 1 and is immunologically distinct from the 56-kDa phorbol-diester hydrolase in mouse liver.
Topics: Animals; Antibody Specificity; Carboxylesterase; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cross Reactions; Estradiol; Kinetics; Liver; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Co-mitogenic tumor promoters suppress the phosphatidylinositol response in lymphocytes during early mitogenesis.
Topics: Animals; Carcinogens; Female; Humans; Lymphocyte Activation; Mice; Phorbol Esters; Phorbols; Phosphates; Phosphatidylcholines; Phosphatidylinositols; Phytohemagglutinins; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters.
Topics: Adenylyl Cyclases; Animals; Carcinogens; Erythrocyte Membrane; Erythrocytes; Fluorides; Isoproterenol; Kinetics; Manganese; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rana pipiens; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Acute effects of tumor-promoting phorbol esters on hepatic intermediary metabolism.
Topics: Animals; Fatty Acids; Food; Gluconeogenesis; Glutamine; Ketone Bodies; Liver; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Starvation; Tetradecanoylphorbol Acetate | 1985 |
The role of C-kinase in the physiological activation of the neutrophil oxidase. Evidence from using pharmacological manipulation of C-kinase activity in intact cells.
Topics: Animals; Diglycerides; Diterpenes; Enzyme Activation; In Vitro Techniques; Latex; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; Neutrophils; Phorbols; Protein Kinase C; Rats; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of histamine-induced acid secretion in rat isolated gastric mucosa by esters of phorbol and 12-deoxyphorbol.
Topics: Animals; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; In Vitro Techniques; Male; Phorbol Esters; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1981 |
Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.
Topics: Animals; Diglycerides; Gizzard, Avian; Kinetics; Molecular Weight; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Phorbols; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Turkeys | 1984 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate stimulates simian virus 40 induction by DNA-damaging agents and tumor initiators.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Cells, Cultured; Cricetinae; Mesocricetus; Mitomycin; Mitomycins; Phorbols; Simian virus 40; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Virus Activation | 1983 |
Phorbol diesters stimulate somatostatin secretion from cultured brain cells.
Topics: Alkaloids; Animals; Cell Line; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Hypothalamus; Lyngbya Toxins; Peptides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pregnancy; Rats; Tetradecanoylphorbol Acetate; Verapamil | 1983 |
A tumor promoter stimulates phosphorylation on tyrosine.
Topics: Animals; Chick Embryo; Fibroblasts; Molecular Weight; Phorbols; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1983 |
Enhancement by phorbol esters of cell growth inhibiting action of interferon.
Topics: 2',5'-Oligoadenylate Synthetase; Cell Division; Cell Line; Cell Transformation, Viral; Drug Resistance; Drug Synergism; Humans; Interferon Type I; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices.
Topics: Animals; Caenorhabditis elegans Proteins; Carbachol; Carcinogens; Carrier Proteins; Hippocampus; Inositol; Inositol Phosphates; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1984 |
Enhancement of aggregation of Chinese hamster V79 cells in rotation culture by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Adhesion; Cell Aggregation; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Dimethyl Sulfoxide; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Preferential growth inhibition of human leukemic versus normal myeloid colony-forming cells by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cell Differentiation; Cells, Cultured; Hematopoietic Stem Cells; Humans; Leukemia; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Effects of tumor-promoting agents on cells of the murine immune system: inhibition of antibody synthesis and of macrophage-mediated tumor cell cytotoxicity.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cytotoxicity, Immunologic; Female; Macrophages; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
The effect of phorbols on metabolic cooperation between human fibroblasts.
Topics: Autoradiography; Cell Communication; Cell Line; Fibroblasts; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Mutation; Phorbols; Tetradecanoylphorbol Acetate; Tritium | 1982 |
Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells.
Topics: Adenylyl Cyclases; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Ethers, Cyclic; Glioma; GTP-Binding Proteins; Hybrid Cells; Naphthalenes; Neuroblastoma; Okadaic Acid; Phorbols; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Ganglia, Sympathetic; Isoquinolines; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Phorbol Esters; Phorbols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rana catesbeiana; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1994 |
[Secretion of peptide YY and truncated glucagon-like peptide 1 by isolated intestinal cells in rats].
Topics: Adult; Animals; Calcium-Transporting ATPases; Chromatography, Affinity; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Ionomycin; Male; Peptide Fragments; Peptide YY; Peptides; Phorbols; Protein Precursors; Rats; Rats, Wistar; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Protein kinase C second messenger system mediates the antisteroidogenic effects of prostaglandin F2 alpha in the ovine corpus luteum in vivo.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Cholesterol Side-Chain Cleavage Enzyme; Corpus Luteum; Dinoprost; Enzyme Activation; Female; Phorbols; Progesterone; Protein Kinase C; RNA, Messenger; Second Messenger Systems; Sheep; Tetradecanoylphorbol Acetate | 1994 |
Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats.
Topics: Alkaloids; Animals; Enzyme Activation; Fasting; Food; Hemodynamics; In Vitro Techniques; Liver; Liver Circulation; Male; Organ Size; Perfusion; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.
Topics: Antigens, CD; Base Sequence; Down-Regulation; Gene Products, nef; HIV-1; Humans; Lymphocyte Activation; Molecular Sequence Data; nef Gene Products, Human Immunodeficiency Virus; NF-kappa B; Phorbols; Phytohemagglutinins; Proto-Oncogene Proteins c-jun; Receptors, Cell Surface; Receptors, Cytokine; Signal Transduction; T-Lymphocytes; Transcription Factors | 1994 |
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidines; Isoquinolines; Perfusion; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pinacidil; Piperazines; Protein Kinase C; Rabbits; Staurosporine; Ventricular Fibrillation | 1993 |
Inhibition of myosin light chain phosphatase during Ca(2+)-independent vasocontraction.
Topics: Animals; Aorta, Thoracic; Calcium; Colforsin; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbols; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1993 |
Monoclonal antibody 8A2-induced retraction appears to be mediated by protein phosphorylation in goldfish retinal ganglion cell axons.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Axons; Calcium; Cyclic AMP; Ethers, Cyclic; Goldfish; Nerve Regeneration; Okadaic Acid; Organ Culture Techniques; Phorbol Esters; Phorbols; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Retinal Ganglion Cells; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation.
Topics: Animals; GTP-Binding Proteins; Inositol Phosphates; Male; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phorbols; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Hormone induction of ascorbic acid transport in immature granulosa cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Ascorbic Acid; Biological Transport; Cellular Senescence; Energy Metabolism; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Granulosa Cells; Insulin-Like Growth Factor I; Kinetics; Phorbols; Phosphotransferases; Rats; Rats, Sprague-Dawley; Sodium; Time Factors | 1996 |
Restoration of the transient outward potassium current by noradrenaline in chagasic canine epicardium.
Topics: Animals; Chagas Disease; Dogs; Heart; In Vitro Techniques; Indoles; Isoproterenol; Maleimides; Membrane Potentials; Mice; Mice, Inbred A; Neomycin; Norepinephrine; Patch-Clamp Techniques; Pericardium; Pertussis Toxin; Phorbols; Potassium Channels; Prazosin; Reference Values; Second Messenger Systems; Tetradecanoylphorbol Acetate; Trypanosoma cruzi; Virulence Factors, Bordetella | 1997 |
Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Enzyme Activation; Motor Endplate; Motor Neurons; Nerve Endings; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Potassium Channel Blockers; Protein Kinase C; Rana pipiens | 1997 |
Facilitation of Ca2+ action potential frequency by a small G protein Rab3A in rat pituitary GH3 cells.
Topics: Action Potentials; Animals; Calcium; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Patch-Clamp Techniques; Peptide Fragments; Peptides; Phorbol 12,13-Dibutyrate; Phorbols; Pituitary Gland; Protein Kinase C; rab3 GTP-Binding Proteins; rab5 GTP-Binding Proteins; ras Proteins; Rats; Thionucleotides; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1997 |
Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons.
Topics: Action Potentials; Animals; Dendrites; Electric Stimulation; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels | 1998 |
Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor.
Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Calcium Channels; Cannabinoids; Carcinogens; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Hormone Antagonists; Indoles; Maleimides; Morpholines; Mutagenesis; Naphthalenes; omega-Conotoxin GVIA; Peptides; Phorbols; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Serine; Signal Transduction; Somatostatin; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells.
Topics: Adenosine Triphosphate; Animals; Bacterial Proteins; Calcium; Cell Line; Cell Membrane Permeability; Cytoplasmic Granules; Enzyme Activation; Exocytosis; Kinetics; Mucins; Mucous Membrane; Phorbols; Protein Kinase C; Rats; Streptolysins; Tetradecanoylphorbol Acetate; Trachea; Uridine Triphosphate | 1998 |
The leukointegrin alpha d/beta 2 (alpha d/CD18): specific changes in surface expression in patients on hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; CD11 Antigens; Cell Adhesion; Female; Flow Cytometry; Humans; Integrin alpha Chains; Integrins; Leukocytes, Mononuclear; Macrophages; Male; Mice; Middle Aged; Phorbols; Receptors, Cytoadhesin; Renal Dialysis; Renal Insufficiency; Time Factors | 1998 |
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels.
Topics: Animals; Chloride Channels; Culture Techniques; Electric Conductivity; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Phorbols; Phosphorylation; Phosphotransferases; Rats; Rats, Wistar | 1998 |
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator.
Topics: Alzheimer Disease; Calcium; Carcinogens; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Activation; Excipients; Fibroblasts; Humans; Immunoblotting; Lactams; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phorbols; Potassium Channels; Protein Kinase C; Tetraethylammonium | 1998 |
Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures.
Topics: Animals; Antioxidants; Brain Ischemia; Cell Death; Cells, Cultured; Chromans; Enzyme Inhibitors; Indoles; Lipid Peroxidation; Maleimides; Mice; Nerve Degeneration; Neuroglia; Neurons; Neurotoxins; Oxidative Stress; Phorbols; Protein Kinase C; Thiobarbituric Acid Reactive Substances; Zinc | 1999 |
Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins.
Topics: Adenosine; Animals; Dihydropyridines; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Phorbol 12,13-Dibutyrate; Phorbols; Propionates; Protein Kinase C; Receptor, Adenosine A3; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synaptic Transmission | 1999 |
P-glycoprotein phosphorylation/dephosphorylation and cellular accumulation of L-DOPA in LLC-GA5 Col300 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Epithelium; Humans; Kidney; Levodopa; Okadaic Acid; Phorbols; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Staurosporine; Time Factors; Verapamil | 1999 |
Mechanisms involved in desensitization of particulate guanylyl cyclase in human airway smooth muscle: the role of protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Humans; Indoles; Maleimides; Muscle, Smooth; Phorbols; Phosphodiesterase Inhibitors; Protein Kinase C; Respiratory System; Solubility; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
Topics: Antigens, CD; CD28 Antigens; Cell Adhesion Molecules; Cells, Cultured; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Jurkat Cells; Kinetics; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Vanadates | 2000 |
Functional differences between splice variants of the murine 5-HT(3A) receptor: possible role for phosphorylation.
Topics: Alternative Splicing; Cell Line; Cyclic AMP; Cyclic GMP; Genetic Variation; Humans; Membrane Potentials; Patch-Clamp Techniques; Phorbols; Phosphorylation; Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A.
Topics: Amides; Animals; Blotting, Western; Calcium; Cattle; Cells, Cultured; Chelating Agents; Ciliary Body; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Phorbols; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Tetradecanoylphorbol Acetate; Trabecular Meshwork | 2000 |
Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)].
Topics: Calcium; Elapid Venoms; Estrenes; Humans; Membrane Potentials; Muscarine; Muscarinic Agonists; Neuroblastoma; Neurons; Norepinephrine; Phorbols; Phosphodiesterase Inhibitors; Potassium; Protein Kinase C; Pyrrolidinones; Receptor, Muscarinic M1; Receptors, Muscarinic; Second Messenger Systems; Stimulation, Chemical; Tritium; Tumor Cells, Cultured | 2001 |
Formal synthesis of (+)-phorbol(1).
Topics: Carcinogens; Phorbols; Stereoisomerism | 2001 |
Activation of protein kinase C increases acetylcholine release from frog motor nerves by a direct action on L-type Ca(2+) channels and apparently not by depolarisation of the terminal.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Enzyme Inhibitors; Motor Neurons; Naphthalenes; Neuromuscular Junction; Nimodipine; Phorbols; Potassium Chloride; Presynaptic Terminals; Protein Kinase C; Rana temporaria; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2001 |
Structural investigation of protein kinase C inhibitors.
Topics: Gossypol; Lyngbya Toxins; Models, Molecular; Naphthalenes; Perylene; Phorbols; Protein Conformation; Protein Kinase C | 1991 |
Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport System X-AG; Animals; Carcinogens; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Indoles; Maleimides; Membrane Potentials; Oocytes; Phorbols; Protein Kinase C; RNA, Complementary; Symporters; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured; Xenopus laevis | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
Regulation of high affinity taurine transport in goldfish and rat retinal cells.
Topics: Animals; Biological Transport; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Goldfish; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbols; Phosphoprotein Phosphatases; Protein Kinase C; Rats; Retina; Taurine | 2000 |
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
Topics: Animals; Calcium; Cation Transport Proteins; Cell Line; Cells, Cultured; Coloring Agents; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Humans; Ion Channels; Kinetics; Mice; Phorbols; Receptors, Drug; Recombinant Proteins; Ruthenium Red; Transfection; TRPV Cation Channels; Tumor Cells, Cultured | 2002 |
Biotransformation of phorbol by human intestinal bacteria.
Topics: Bacteria; Biotransformation; Humans; Intestines; Magnetic Resonance Spectroscopy; Phorbols | 2002 |
4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC.
Topics: Blotting, Western; Cells, Cultured; Cilia; Dose-Response Relationship, Drug; Humans; Indicators and Reagents; Nasal Mucosa; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 2002 |
An asymmetric synthesis of aza analogues of the tricyclic skeleton of daphnane and the ABC ring system of phorbol.
Topics: Aza Compounds; Catalysis; Chemistry, Organic; Crystallography, X-Ray; Cyclization; Diterpenes; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Phorbols; Stereoisomerism; Terpenes | 2003 |
Effect of bursal anti-steroidogenic peptide and immunoglobulin G on neonatal chicken B-lymphocyte proliferation.
Topics: Animals; Animals, Newborn; B-Lymphocytes; Bursa of Fabricius; Cell Division; Cells, Cultured; Chickens; DNA; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunoglobulin G; Peptides; Phorbols; Rabbits; Steroids | 2003 |
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
Topics: Alkaloids; Animals; Benzophenanthridines; Clozapine; Drug Interactions; Electric Stimulation; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fluorobenzenes; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Peptide Fragments; Phenanthridines; Phorbols; Piperidines; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Models of anergy in the human Jurkat T cell line.
Topics: Calcium; CD28 Antigens; CD3 Complex; Clonal Anergy; Down-Regulation; Genes, T-Cell Receptor; Humans; Hydrogen Peroxide; Interleukin-2; Jurkat Cells; Models, Immunological; Muromonab-CD3; Phorbols; Polymerase Chain Reaction; Signal Transduction; T-Lymphocytes | 2003 |
Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.
Topics: Animals; Dose-Response Relationship, Drug; Endocytosis; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Phosphorylation; Protein Kinase C; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2005 |
Induction of long-term depression and phosphorylation of the delta2 glutamate receptor by protein kinase C in cerebellar slices.
Topics: Animals; Animals, Newborn; Blotting, Western; Cerebellum; Electrophoresis; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Molecular Sequence Data; Patch-Clamp Techniques; Phorbols; Phosphorylation; Protein Kinase C; Receptors, Glutamate | 2005 |
Functional expression of transient receptor potential vanilloid 4 in the mouse cochlea.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Chelating Agents; Cochlea; Drug Interactions; Egtazic Acid; Gene Expression Regulation; Hypotonic Solutions; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phorbols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ruthenium Red; TRPV Cation Channels | 2006 |
Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice.
Topics: Alprostadil; Animals; Benzo(a)pyrene; Bone Marrow Cells; Chromosome Aberrations; Erythroblasts; Gamma Rays; gamma-Linolenic Acid; Male; Mice; Micronucleus Tests; Mutagens; Phenytoin; Phorbols; Reticulocytes | 2006 |
Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Endocannabinoids; Endotoxemia; Lipopolysaccharides; Male; Mesentery; Norepinephrine; Phorbols; Polyunsaturated Alkamides; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tongue; TRPV Cation Channels; Vasoconstrictor Agents; Vasodilation | 2007 |
Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition.
Topics: Aromatase; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclooxygenase 2 Inhibitors; Dexamethasone; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Microsomes; Molecular Structure; Nitrobenzenes; Phorbols; Sulfonamides; Testosterone | 2008 |
Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV.
Topics: Anti-HIV Agents; Chemotherapy, Adjuvant; HIV-1; Humans; Models, Molecular; Phorbol Esters; Phorbols; Viral Load; Virus Latency | 2008 |
Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta.
Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Forkhead Box Protein O1; Forkhead Transcription Factors; G1 Phase; Humans; Isoenzymes; Mitogen-Activated Protein Kinases; Phorbols; Phosphorylation; Protein Kinase C-delta; Protein Transport; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; S Phase; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transfection | 2008 |
Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin.
Topics: Amiloride; Animals; Benzamides; Calcineurin; Calcium; Chelating Agents; Chorda Tympani Nerve; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Fluid; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Knockout; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Chloride; Taste; Taste Buds; Taste Threshold; TRPV Cation Channels | 2009 |
Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model.
Topics: Animals; Aorta; Arteries; Blood Vessels; Calcium Signaling; Femoral Artery; Hindlimb; Ischemia; Lower Extremity; Male; NFATC Transcription Factors; Phorbols; Random Allocation; Stress, Mechanical; Sus scrofa | 2010 |
Molecular regulation of NADPH oxidase 5 via the MAPK pathway.
Topics: Butadienes; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Ionomycin; Ionophores; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Proteins; Mitogen-Activated Protein Kinases; NADPH Oxidase 5; NADPH Oxidases; Nitriles; Phorbols; Phosphorylation; Protein Kinase C; RNA, Small Interfering | 2011 |
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Movement; Cell Transformation, Neoplastic; Cytoskeleton; Disease Progression; Endothelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Neovascularization, Pathologic; Papilloma; Phorbols; Protein Serine-Threonine Kinases; Skin Neoplasms; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Two new tigliane diterpene esters from the flower buds of Daphne genkwa.
Topics: Daphne; Diterpenes; Drugs, Chinese Herbal; Esters; Flowers; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phorbols | 2013 |
Mechanisms of resveratrol-induced changes in [Ca(2+)]i and cell viability in PC3 human prostate cancer cells.
Topics: Apoptosis; Calcium; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Cell Survival; Homeostasis; Humans; Male; Phorbols; Prostatic Neoplasms; Protein Kinase C; Protein Kinase Inhibitors; Resveratrol; Stilbenes | 2013 |
Modulation of COX, LOX and NFκB activities by Xanthium spinosum L. root extract and ziniolide.
Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; HeLa Cells; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Inhibitory Concentration 50; Lipoxygenase Inhibitors; Lipoxygenases; NF-kappa B; Phorbols; Phytotherapy; Plant Extracts; Plant Roots; Sesquiterpenes, Guaiane; Xanthium | 2013 |
Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
Topics: Aedes; Alkaloids; Animals; Anopheles; Anti-Infective Agents; Bacteria; Benzamides; Cell Survival; Chlorocebus aethiops; Croton; Esters; Fungi; Leishmania; Medicine, African Traditional; Molecular Structure; Phorbol Esters; Phorbols; Piperidones; Plant Leaves; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Vero Cells | 2013 |
Palmitate-stimulated monocytes induce adhesion molecule expression in endothelial cells via IL-1 signaling pathway.
Topics: Cell Adhesion Molecules; E-Selectin; Endothelial Cells; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Monocytes; Palmitates; Phorbols; Signal Transduction | 2015 |
Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.
Topics: Animals; Antineoplastic Agents; Biological Products; Bryostatins; Bryozoa; Cell Line, Tumor; Humans; Models, Molecular; Phorbols; Protein Kinase C | 2014 |
Nineteen-step total synthesis of (+)-phorbol.
Topics: Bicyclic Monoterpenes; Biological Products; Chemistry Techniques, Synthetic; Diterpenes; Molecular Structure; Monoterpenes; Oxygen; Phorbol Esters; Phorbols; Stereoisomerism | 2016 |
Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia.
Topics: Animals; Calcium; Ganglia, Sensory; Neurons; Phorbols; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; TRPV Cation Channels; Vestibular Nerve | 2016 |
RAS-Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; B7-H1 Antigen; Butadienes; Cell Adhesion; Cell Movement; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Phorbols; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; STAT3 Transcription Factor; Transcription Factor AP-1; Transcription Initiation Site | 2016 |
Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation.
Topics: Biomarkers; CD4-Positive T-Lymphocytes; Cells, Cultured; Diterpenes; Drug Agonism; Early Growth Response Protein 1; Early Growth Response Protein 3; Gene Expression; HIV Infections; HIV-1; Humans; Jurkat Cells; Male; Phorbols; Protein Kinase C; Sequence Analysis, RNA; Virus Activation; Virus Latency | 2017 |
Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.
Topics: Antineoplastic Agents, Phytogenic; Diterpenes; Drug Screening Assays, Antitumor; Euphorbia; HL-60 Cells; Humans; Inhibitory Concentration 50; K562 Cells; Latex; Magnetic Resonance Spectroscopy; Molecular Structure; Phorbols; Plant Roots; Spectrometry, Mass, Electrospray Ionization | 2017 |
Phorbol 12-myristate 13-acetate stimulation under hypoxia induces nuclear swelling with DNA outflow but not extracellular trap formation of neutrophils.
Topics: Acetates; DNA; Extracellular Traps; Histones; Humans; Hypoxia; Lung Diseases; Myristic Acid; Neutrophils; Phorbols; Tetradecanoylphorbol Acetate | 2022 |
Bioinformatics of Differentially Expressed Genes in Phorbol 12-Myristate 13-Acetate-Induced Megakaryocytic Differentiation of K562 Cells by Microarray Analysis.
Topics: Acetates; Cell Differentiation; Computational Biology; Humans; K562 Cells; Megakaryocytes; Microarray Analysis; Myristic Acid; Phorbols; Tetradecanoylphorbol Acetate; Thrombopoiesis | 2022 |
Biphasic alcoholysis coupled with high-speed countercurrent chromatography for high performance on separating phorbol from Croton tiglium Linn extracts.
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Croton Oil; Phorbol Esters; Phorbols; Plant Extracts; Solvents | 2023 |
Insertion Depth Modulates Protein Kinase C-δ-C1b Domain Interactions with Membrane Cholesterol as Revealed by MD Simulations.
Topics: Bryostatins; Humans; Isoenzymes; Lactones; Phorbol Esters; Phorbols; Protein Kinase C-delta | 2023 |