phorbols has been researched along with methotrexate in 6 studies
| Studies (phorbols) | Trials (phorbols) | Recent Studies (post-2010) (phorbols) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
|---|---|---|---|---|---|
| 2,217 | 0 | 72 | 41,593 | 5,666 | 11,969 |
| Protein | Taxonomy | phorbols (IC50) | methotrexate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.8 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
| Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
| Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
| Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
| Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
| Thymidylate synthase | Homo sapiens (human) | 0.343 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
| Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
| Folate receptor beta | Homo sapiens (human) | 0.1585 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Reduced folate transporter | Homo sapiens (human) | 0.012 | |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
| Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barsoum, J; Varshavsky, A | 1 |
| Bojan, F; Fox, M; Kinsella, AR | 2 |
| Grzelakowska-Sztabert, B | 1 |
| Varshavsky, A | 1 |
| Kinzel, V; Richards, J; Stöhr, M | 1 |
6 other study(ies) available for phorbols and methotrexate
| Article | Year |
|---|---|
Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.
Topics: Animals; Arginine Vasopressin; Carcinogens; Cells, Cultured; Clone Cells; Drug Resistance; Epidermal Growth Factor; Gene Amplification; Genes; Hormones; Insulin; Methotrexate; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1983 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on selection of drug-resistant phenotypes in rodent cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cadmium; Cell Line; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; Drug Resistance; Lung; Methotrexate; Mice; Phenotype; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1984 |
Effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate on recovery of methotrexate-, N-(phosphonacetyl)-L-aspartate-, and cadmium-resistant colony-forming mouse and hamster cells.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cadmium; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Resistance; Kinetics; Lung; Methotrexate; Mice; Organophosphorus Compounds; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate | 1983 |
[Cocarcinogen as a factor increasing the incidence of mutation responsible for cellular resistance to antifolates].
Topics: Animals; Cell Survival; Cells, Cultured; Cocarcinogenesis; Drug Resistance; Genes; Humans; Methotrexate; Mice; Mutation; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1982 |
Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion.
Topics: Animals; Cell Count; Cell Division; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplification; Methotrexate; Mice; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1981 |
Responses of synchronized HeLa cells to the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate as evaluated by flow cytometry.
Topics: Cell Cycle; DNA, Neoplasm; HeLa Cells; Humans; Methotrexate; Phorbol Esters; Phorbols; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |