Page last updated: 2024-09-04

phorbols and carbachol

phorbols has been researched along with carbachol in 19 studies

Compound Research Comparison

Studies
(phorbols)
Trials
(phorbols)
Recent Studies (post-2010)
(phorbols)
Studies
(carbachol)
Trials
(carbachol)
Recent Studies (post-2010) (carbachol)
2,21707213,91881968

Protein Interaction Comparison

ProteinTaxonomyphorbols (IC50)carbachol (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.7849
Muscarinic acetylcholine receptor M4Homo sapiens (human)2.0626
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)3.4134
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)2.9961
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)2.535
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)2.9961
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)2.6638
Muscarinic acetylcholine receptor M1Homo sapiens (human)4.849
Muscarinic acetylcholine receptor M3Homo sapiens (human)4.99

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199017 (89.47)18.7374
1990's2 (10.53)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berlin, RD; Krawiec, JA; Oliver, JM1
Raufman, JP1
Ichida, T; Takuma, T1
Eckhardt, L; Imamura, K; Kimura, T; Schulz, I1
Burnham, DB; Hootman, SR; Munowitz, P; Williams, JA1
Ambrosini, A; Di Virgilio, F; Meldolesi, J; Pozzan, T; Vicentini, LM1
Brown, JH; Orellana, SA; Solski, PA1
Houchi, H; Nakanishi, A; Ohuchi, T; Oka, M; Uddin, MM1
Kanba, KS; Kanba, S; Richelson, E1
Brown, JH; Harden, TK; Heng, MM1
el-Fakahany, EE; Lai, WS2
Brocklehurst, KW; Morita, K; Pollard, HB; Tomares, SM1
Hanson, PJ; Shaw, GP1
Gunther, GR1
de Pont, JJ; Fleuren-Jakobs, AM1
Burgoyne, RD; Norman, KM1
Janowsky, A; Labarca, R; Patel, J; Paul, SM1
Bymaster, FP; DeLapp, NW; Eckols, K; Mitch, CH; Shannon, HE; Ward, JS1

Other Studies

19 other study(ies) available for phorbols and carbachol

ArticleYear
Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice.
    The Journal of cell biology, 1976, Volume: 69, Issue:1

    Topics: Atropine; Carbachol; Cells, Cultured; Chediak-Higashi Syndrome; Dose-Response Relationship, Drug; Lysosomes; Phorbols

1976
Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach.
    Biochimica et biophysica acta, 1992, Apr-30, Volume: 1135, Issue:1

    Topics: Animals; Calcimycin; Calmodulin; Carbachol; Cholera Toxin; Gastric Mucosa; Guinea Pigs; Imidazoles; In Vitro Techniques; Kinetics; Male; Phorbol 12,13-Dibutyrate; Phorbols; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate

1992
Phorbol ester stimulates amylase secretion from rat parotid cells.
    FEBS letters, 1986, Apr-07, Volume: 199, Issue:1

    Topics: Amylases; Animals; Bucladesine; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Exocytosis; Parotid Gland; Phorbols; Protein Kinase C; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate

1986
Ca2+-, phorbol ester-, and cAMP-stimulated enzyme secretion from permeabilized rat pancreatic acini.
    The American journal of physiology, 1986, Volume: 250, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcium; Carbachol; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytoplasmic Granules; Digitonin; Egtazic Acid; Pancreas; Phorbols; Rats; Rats, Inbred Strains; Saponins; Spermine; Tetradecanoylphorbol Acetate; Trifluoperazine

1986
Regulation of protein phosphorylation in pancreatic acini. Distinct effects of Ca2+ ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate.
    The Biochemical journal, 1986, Apr-01, Volume: 235, Issue:1

    Topics: Amylases; Animals; Calcimycin; Carbachol; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Pancreas; Phorbols; Phosphorylation; Proteins; Species Specificity; Tetradecanoylphorbol Acetate

1986
Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells.
    Biochemical and biophysical research communications, 1985, Feb-28, Volume: 127, Issue:1

    Topics: Animals; Calcium; Carbachol; Cell Line; Hydrolysis; Kinetics; Neurosecretory Systems; Phorbols; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tetradecanoylphorbol Acetate

1985
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.
    The Journal of biological chemistry, 1985, May-10, Volume: 260, Issue:9

    Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Humans; Hydrolysis; Phorbol Esters; Phorbols; Phosphatidylinositols; Receptors, Muscarinic; Tetradecanoylphorbol Acetate

1985
Phorbol ester stimulates catecholamine synthesis in isolated bovine adrenal medullary cells.
    FEBS letters, 1985, Sep-02, Volume: 188, Issue:2

    Topics: Adrenal Medulla; Animals; Bucladesine; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; In Vitro Techniques; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Tyrosine

1985
The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).
    European journal of pharmacology, 1986, Jun-05, Volume: 125, Issue:1

    Topics: Animals; Carbachol; Cell Line; Cyclic GMP; Inositol Phosphates; Mice; Neuroblastoma; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Muscarinic; Sugar Phosphates; Tetradecanoylphorbol Acetate

1986
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.
    Molecular pharmacology, 1986, Volume: 30, Issue:3

    Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Isoproterenol; Oxotremorine; Phorbols; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Tetradecanoylphorbol Acetate

1986
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate

1987
The phorbol ester TPA enhances A23187--but not carbachol- and high K+-induced catecholamine secretion from cultured bovine adrenal chromaffin cells.
    Biochemical and biophysical research communications, 1985, Jun-14, Volume: 129, Issue:2

    Topics: Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Phorbols; Potassium; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate

1985
Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Animals; Binding Sites; Carbachol; Clone Cells; Enzyme Activation; Kinetics; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Muscarinic

1988
Inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate on acid secretion by rat stomach in vivo.
    FEBS letters, 1986, Jun-09, Volume: 201, Issue:2

    Topics: Animals; Carbachol; Enzyme Activation; Gastric Acid; Gastric Mucosa; Histamine; Male; Pentagastrin; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate

1986
Effect of 12-O-tetradecanoyl-phorbol-13-acetate on Ca2+ efflux and protein discharge in pancreatic acini.
    The Journal of biological chemistry, 1981, Dec-10, Volume: 256, Issue:23

    Topics: Amylases; Animals; Calcimycin; Calcium; Carbachol; Ceruletide; Cyclic AMP; Cyclic GMP; Female; Guinea Pigs; Kinetics; Pancreas; Phorbols; Proteins; Tetradecanoylphorbol Acetate

1981
Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.
    FEBS letters, 1984, May-07, Volume: 170, Issue:1

    Topics: Amylases; Animals; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Pancreas; Phorbols; Rabbits; Tetradecanoylphorbol Acetate; Time Factors

1984
Effect of calmidazolium and phorbol ester on catecholamine secretion from adrenal chromaffin cells.
    Biochimica et biophysica acta, 1984, Sep-14, Volume: 805, Issue:1

    Topics: Adrenal Medulla; Animals; Calcimycin; Carbachol; Catecholamines; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Kinetics; Phorbols; Potassium; Tetradecanoylphorbol Acetate

1984
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices.
    Biochemical and biophysical research communications, 1984, Sep-17, Volume: 123, Issue:2

    Topics: Animals; Caenorhabditis elegans Proteins; Carbachol; Carcinogens; Carrier Proteins; Hippocampus; Inositol; Inositol Phosphates; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate

1984
The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells.
    Life sciences, 1995, Volume: 57, Issue:12

    Topics: Amyloid beta-Protein Precursor; Animals; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Electrophoresis; Humans; Immunoblotting; Muscarinic Agonists; Phorbols; Pyridines; Thiadiazoles

1995