phorbol-13-monoacetate and bryostatin-1

phorbol-13-monoacetate has been researched along with bryostatin-1* in 1 studies

Other Studies

1 other study(ies) available for phorbol-13-monoacetate and bryostatin-1

Article	Year
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process. Organic letters, 2003, Feb-20, Volume: 5, Issue:4 [structure: see text] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in C(2)H(3)CN containing 25% (2)H(2)O have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1). NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1. Topics: Antineoplastic Agents; Binding Sites; Bryostatins; Humans; Lactones; Macrolides; Nuclear Magnetic Resonance, Biomolecular; Phorbol Esters; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Structure-Activity Relationship; Titrimetry	2003

Article

Year

Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.

Organic letters, 2003, Feb-20, Volume: 5, Issue:4

[structure: see text] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in C(2)H(3)CN containing 25% (2)H(2)O have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1). NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1.

Topics: Antineoplastic Agents; Binding Sites; Bryostatins; Humans; Lactones; Macrolides; Nuclear Magnetic Resonance, Biomolecular; Phorbol Esters; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Structure-Activity Relationship; Titrimetry

2003