phorbol 12,13-dibutyrate has been researched along with staurosporine in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (5.00) | 18.7374 |
| 1990's | 170 (85.00) | 18.2507 |
| 2000's | 19 (9.50) | 29.6817 |
| 2010's | 1 (0.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eckberg, WR; Palazzo, RE | 1 |
| Alexandre, A; Deana, R; Donella-Deana, A; Francesconi, M; Ruzzene, M | 1 |
| Fisher, J; Hankins, WD; Isaacs, MA; Spivak, JL | 1 |
| Croatto, M; Hamilton, JA; Phillips, WA; Veis, N | 1 |
| Angenstein, F; Jork, R; Staak, S | 1 |
| Deth, RC; Jagadeesh, G | 1 |
| Diehl, H; Folch, H; Guarda, MI; Maldonado, C; Ojeda, F | 1 |
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Bockaert, J; Curry, K; Homburger, V; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Hedman, H; Lundgren, E | 1 |
| Fabbro, D; Jaken, S; Kiley, SC; Parker, PJ | 1 |
| Cahill, AL; Pavlović-Surjancev, B; Perlman, RL | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Abdel-Latif, AA; Zhang, Y | 1 |
| Meldrum, BS; Smith, SE | 1 |
| Izawa, T; Komabayashi, T; Noguchi, M; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Engleman, EG; Rajasekar, S; Ruegg, CL; Stein, BS | 1 |
| Hino, A; Isono, K; Magae, J; Nagai, K | 1 |
| Isono, K; Kurisaki, T; Magae, J; Nagai, K; Yamasaki, M | 1 |
| Azula, FJ; Font, J; Macarulla, JM; Marino, A; Nieva, N; Trueba, M | 1 |
| Cragoe, EJ; Gupta, S; Ruderman, NB; Sussman, I | 1 |
| Burgess, GM; Coote, PR; Dunn, PM; Rang, HP; Wood, JN | 1 |
| Davis, PD; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE | 1 |
| Bryant, SH; Conte Camerino, D; Govoni, S; Tricarico, D | 1 |
| Feldman, D; Krishnan, AV | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Bryant, SH; Conte-Camerino, D | 1 |
| Daniele, E; Govoni, S; Lograno, MD; Trabucchi, M | 1 |
| Alberola-Ila, J; Lozano, F; Places, L; Vives, J | 1 |
| Cushing, DJ; Makujina, SR; Mustafa, SJ; Sabouni, MH | 1 |
| Kageyama, M; Mori, T; Taira, N; Yanagisawa, T | 1 |
| Endou, M; Hattori, Y; Kanno, M; Tohse, N | 1 |
| Balapure, AK; Brunswick, M; Feuerstein, N; Glazer, RI; June, CH; Mond, JJ; Witherspoon, K | 1 |
| Arner, EC; Pratta, MA | 1 |
| Ajakane, M; Baudet, V; Bellevergue, P; Boissin, P; Boursier, E; Coste, H; Grand-Perret, T; Loriolle, F; Pianetti, P; Toullec, D | 1 |
| Miyata, N; Otomo, S; Tsuchida, K | 1 |
| Béhé, P; Meves, H; Schäfer, S | 1 |
| Lambert, A; Mitchell, R; Robertson, WR; Talbot, JA | 1 |
| Huang, R; Kucera, GL; Rittenhouse, SE | 1 |
| Cohen, ML; Lucaites, VL; Mendelsohn, LG; Secrest, RJ | 1 |
| Braquet, P; Ferber, E; Fischer, G; Harell, T; Her, E; Naor, Z; Reiss, N; Zor, U | 1 |
| Harmody, D; Longley, RE | 1 |
| Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM | 1 |
| Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
| Lapetina, EG; Nolan, RD; Oberdisse, E | 1 |
| Blockaert, J; Finiels-Marlier, F; le Peuch, C; Manzoni, OJ; Sassetti, I; Sladeczek, FA | 1 |
| Crooke, ST; Nakada, MT; Stadel, JM | 1 |
| Lapetina, EG; Yamamoto, K | 1 |
| de Boland, AR; Norman, A | 1 |
| Pfeffer, LM; Reich, NC | 1 |
| Parker, PJ; Schaap, D | 1 |
| Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S | 1 |
| Rembold, CM; Weaver, BA | 1 |
| Duronio, V; Jacobs, S | 1 |
| Bonser, RW; Garland, LG; Randall, RW; Spacey, GD | 1 |
| Abebe, W; MacLeod, KM | 1 |
| Singer, HA | 1 |
| Bettaney, J; Dray, A; Forster, P | 1 |
| Brüne, B; Lapetina, EG; Molina y Vedia, L | 1 |
| Ikebuchi, H; Saito, Y; Suzuki, K; Suzuki, S; Terao, T | 1 |
| Cobbold, PH; Cuthbertson, KS; Dixon, CJ; Sanchez-Bueno, A; Woods, NM | 1 |
| Buenaga, LJ; Do, UH; Gross, JL; Herblin, WF; Pounds, JS; Stephens, LE | 1 |
| Cabot, MC; Cao, HT; Welsh, CJ; Zhang, ZC | 1 |
| Badwey, JA; Curnutte, JT; Heyworth, PG; Robinson, JM | 1 |
| Auguet, M; Braquet, P; Chabrier, PE; Delaflotte, S | 1 |
| Allgaier, C; Bartmann, P; Hertting, G; Jackisch, R | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Dray, A; Perkins, MN | 1 |
| Isono, K; Magae, J; Osada, H; Watanabe, C | 1 |
| Fallon, RJ; Schwartz, AL | 1 |
| Bettaney, J; Dray, A; Forster, P; Perkins, MN | 1 |
| Kato, Y; Morimoto, M; Nomoto, H; Takahashi, I; Tamaoki, T; Tomita, F | 1 |
| Gähwiler, BH; Scanziani, M; Thompson, SM | 1 |
| de Prost, D; Hakim, J; Khechai, F; Ollivier, V; Ramani, M; Ternisien, C; Vu, T | 1 |
| Benishin, CG; Ren, J | 1 |
| Altman, A; Baier, G; Baier-Bitterlich, G; Bonnefoy-Berard, N; Burn, P; Coggeshall, KM; Gulbins, E; Langlet, C; Telford, D; Wittinghofer, A | 1 |
| Kimura, T; Satoh, S; Suzuki, Y | 1 |
| Egashira, K; Fukai, T; Ito, A; Nakaike, R; Sakata, M; Shimokawa, H; Takayanagi, T; Takeshita, A | 1 |
| Collier, ML; Hume, JR | 1 |
| Budworth, J; Gescher, A | 1 |
| Giaid, A; Harrison, DG; Kurz, S; Münzel, T; Stewart, DJ | 1 |
| Berk, BC; Peterson, TE; Tseng, H | 1 |
| Fukao, M; Hattori, Y; Kanno, M; Kawasaki, H | 1 |
| Nishio, I; Sasajima, H; Shima, H; Toyoda, Y | 1 |
| Brophy, C; Isales, C; Rasmussen, H; Takuwa, Y; Throckmorton, D; Whitney, G; Yeh, J | 1 |
| Crevel, H; Marthan, R; Rossetti, M; Savineau, JP | 1 |
| Gahmberg, CG; Valmu, L | 1 |
| Kopp, UC; Smith, LA | 1 |
| Blanc, E; Recasens, M; Vignes, M | 1 |
| Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y | 1 |
| Kitamura, K; Kuriyama, H; Oike, M | 1 |
| Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ | 1 |
| Black, JL; Yang, KX | 1 |
| Moallem, E; Naveh-Many, T; Silver, J | 1 |
| Terrian, DM; Ways, DK | 1 |
| Ehlers, MR; Riordan, JF; Scholle, RR | 1 |
| Aharon, A; Kraiem, Z; Sadeh, O; Yosef, M | 1 |
| Bretschneider, E; Glusa, E; Paintz, M | 1 |
| Hall, IP; Hill, SJ; McCreath, G | 1 |
| Godson, C; Li, SL; Prentki, M; Roche, E; Schlegel, W; Zhao, SJ | 1 |
| Balfagón, G; Encabo, A; Ferrer, M; Marín, J | 1 |
| Bussolati, O; Franchi-Gazzola, R; Gazzola, GC; Visigalli, R | 1 |
| Fresno, M; Mazana, J; Pimentel-Muiños, FX | 1 |
| Hurn, E; Wright, G | 1 |
| Ko, FN; Teng, CM; Yu, SM | 1 |
| Alverez, J; Garcia-Sancho, J; Montero, M | 1 |
| Pimplikar, SW; Simons, K | 1 |
| Balfagón, G; de Sagarra, MR; Encabo, A; Ferrer, M; Marín, J; Peiró, C; Redondo, J | 1 |
| Delvaux, A; Demaerschalck, I; Octave, JN | 1 |
| Nakashio, A; Shibata, S; Ueki, S; Watanabe, S | 1 |
| Skoglund, G | 1 |
| Booth, RF; Budd, JM; Hallam, TJ; Merritt, JE; Sullivan, JA | 1 |
| Chaki, S; Muramatsu, M; Otomo, S | 1 |
| Kawasaki, K; Shinohara, S | 1 |
| Black, SC; Chi, L; Fagbemi, SO; Friedrichs, GS; Lucchesi, BR | 1 |
| Combadiere, C; Hakim, J; Perianin, A; Rais, S | 1 |
| Burkhard, C; Finci-Cerkez, V; Meda, P; Rochat, T | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Martin, J; Meenakshi, T; Ross, FP; Teitelbaum, SL | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Barajas-López, C | 1 |
| Alvarez, J; Garcia-Sancho, J; Montero, M | 1 |
| Johnson, MS; Mitchell, R; Simpson, J | 1 |
| Endoh, M; Kasai, H; Norota, I; Takanashi, M | 1 |
| Bryant, SH; Camerino, DC; Tricarico, D; Wagner, R | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R | 1 |
| Tsien, RW; Yang, J | 1 |
| Cooper, DM; Yoshimura, M | 1 |
| Rossignol, B; Sergheraert, C; Zoukhri, D | 1 |
| Bourne, HR; Conklin, BR; Herzmark, P; Lustig, KD; Taussig, R | 1 |
| Aggarwal, S; Coca-Prados, M; Delamere, NA | 1 |
| Celis, JE; Rasmussen, HH | 1 |
| Fredholm, BB; Lerner, UH; Ljunggren, O; Ljunghall, S; Nordstedt, C | 1 |
| Combadière, C; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Hill, SJ; Iredale, PA; Kendall, DA; Martin, KF | 1 |
| Kitamura, Y; Miyazaki, A; Nomura, Y | 1 |
| Berrie, CP; Cobbold, PH | 1 |
| Egashira, K; Fukumoto, Y; Ito, A; Kadokami, T; Shimokawa, H; Takayanagi, T; Takeshita, A | 1 |
| Moreland, RS; Rokolya, A; Walsh, MP | 1 |
| Martin, P; Suzuki, K; Yamada, H | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Dawson, JJ; Iannazzo, L; Majewski, H | 1 |
| Koda, H; Kumazawa, T; Leng, S; Mizumura, K | 1 |
| Collyn, L; Dumont, JE; Lejeune, C; Mockel, J; Rocmans, P; Taton, M | 1 |
| Bunn, SJ; Cheah, TB; Loneragan, K; Marley, PD | 1 |
| Bevan, JA; Laher, I; Xie, H | 1 |
| Bonci, A; Williams, JT | 1 |
| Keiser, HR; Oriji, GK | 2 |
| Hsu, MF; Lin, CN; Raung, SL; Tsao, LT; Wang, JP | 1 |
| Masui, H; Wakabayashi, I | 1 |
| Nash, MS; Osborne, NN; Wood, JP | 1 |
| Goodyer, CG; Oh, LY; Olivier, A; Yong, VW | 1 |
| Fujimoto, R; Hata, F; Ishii, T; Nishio, H; Saitoh, N; Takeuchi, T | 1 |
| Alonso-Torre, SR; García-Sancho, J | 1 |
| Balfagón, G; Conde, MV; Encabo, A; Ferrer, M; Gómez-Gerique, JA; Marín, J; Porres, A | 1 |
| Dorman, RV; Ruehr, ML; Zhang, L | 1 |
| Gomi, Y; Tsunobuchi-Ushijima, H | 1 |
| Borin, ML | 1 |
| Koda, H; Kumazawa, T; Mizumura, K | 2 |
| Kawasaki, H | 1 |
| Benussi, L; Bianchetti, A; Binetti, G; Gasparini, L; Govoni, S; Racchi, M; Trabucchi, M | 1 |
| Lerma, J; Rodríguez-Moreno, A | 1 |
| Auslender, M; Obejero-Paz, CA; Scarpa, A | 1 |
| Moreland, RS; Rokolya, A; Singer, HA; Walsh, MP | 1 |
| Fukao, M; Hattori, Y; Kanno, M; Kitabatake, A; Sakuma, I; Sato, A | 1 |
| Spurney, RF | 1 |
| Ciereszko, RE; Guan, Z; Ottobre, AC; Ottobre, JS; Petroff, BK; Stokes, BT | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Nawabi, A; Ponnathpur, V; Ray, S; Reed, JC; Self, S | 1 |
| Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F | 1 |
| Nicolás, JM; Renard-Rooney, DC; Thomas, AP | 1 |
| Imamura, Y; Ishikawa, T; Nakanishi, O | 1 |
| Dugué, B; Titievsky, A; Törnquist, K; Tuominen, R; Vainio, P | 1 |
| Duchén, M; Etcheberrigaray, R; Ibarreta, D; Kozikowski, AP; Ma, D; Qiao, L | 1 |
| Alvarez, LJ; Candia, OA; Turner, HC; Zamudio, AC | 1 |
| Altura, BM; Altura, BT; Jover, T | 1 |
| Dietz, R; Haller, H; Li, PF; Maasch, C; von Harsdorf, R | 1 |
| Ford, BD; Ivy, MT; Mtshali, CP; Townsel, JG | 1 |
| Leonard, JP; Liao, GY | 1 |
| Chong, YH; Lee, MJ | 2 |
| Brian, EC; de Graan, PN; de Vries, KJ; Geijtenbeek, A; Ghijsen, WE; Verhage, M | 1 |
| Björklund, S; Dugué, B; Titievsky, A; Törnquist, K; Tuominen, RK; Vainio, PJ | 1 |
| Cantwell, AM; Long, W; Longo, LD; Miguel, C; Nanyonga, AT; Saito, T; Windemuth, RS; Zhang, L; Zhao, Y | 1 |
| Asghar, M; Hussain, T; Lokhandwala, MF | 1 |
| Balla, Z; Edes, I; Ferdinandy, P; Flameng, W; Mubagwa, K; Pongo, E; Szilvassy, Z | 1 |
| Nagy, Z; Radeff, J; Stern, PH | 1 |
| Chen, WY; Shi, QX; Yuan, YY; Zhang, XY | 1 |
| Iwata, N; Kataoka, Y; Masui, H; Wakabayashi, I | 1 |
| Lee, SY; Oh, S; Ryoo, IJ; Shin, MH; Yoo, ID; Yun, B | 1 |
| Dal Fiume, C; Guidobono, F; Maestroni, A; Ravasi, F; Rubinacci, A; Villa, I | 1 |
| Ciereszko, R; Dusza, L; Górska, T; Kaminska, B; Opalka, M | 1 |
| Searl, TJ; Silinsky, EM | 1 |
| Bełtowski, J; Borkowska, E; Jamroz-Wiśniewska, A; Marciniak, A; Wójcicka, G | 1 |
| Krebs, CE; Liu, DS; Liu, SJ | 1 |
| Fujita, R; Kawasaki, S; Kimura, S; Matsumoto, M; Sasaki, K; Watanabe, S | 1 |
| Namiki, H; Takahashi, H | 1 |
| Asgari, AR; Janahmadi, M; Vatanparast, J | 1 |
| Corriveau, S; Massenavette, L; Pasquier, JC; Paul, W; Rousseau, É | 1 |
200 other study(ies) available for phorbol 12,13-dibutyrate and staurosporine
| Article | Year |
|---|---|
Regulation of M-phase progression in Chaetopterus oocytes by protein kinase C.
Topics: Alkaloids; Animals; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Isoquinolines; Maturation-Promoting Factor; Mitosis; Oocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Polychaeta; Protamine Kinase; Protein Kinase C; Seawater; Staurosporine; Sulfonamides | 1992 |
The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin.
Topics: Adenosine Triphosphate; Alkaloids; Arachidonic Acid; Blood Platelets; Butylated Hydroxytoluene; Diglycerides; Drug Synergism; Humans; In Vitro Techniques; Ionomycin; Kinetics; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Staurosporine | 1992 |
Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Erythropoiesis; Erythropoietin; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinases; Protein Tyrosine Phosphatases; Signal Transduction; Staurosporine; Vanadates; Zinc | 1992 |
Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production.
Topics: Alkaloids; Animals; Biological Transport; Bone Marrow Cells; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Endotoxins; Granulocyte-Macrophage Colony-Stimulating Factor; Inositol Phosphates; Iodine Radioisotopes; Macrophages; Mice; Mice, Inbred CBA; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Phorbol ester-induced changes in rat hippocampal glycoprotein fucosylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Fucose; Glycoproteins; Hippocampus; In Vitro Techniques; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Rats; Staurosporine | 1992 |
Phorbol ester and staurosporine modulation of antagonist and agonist binding to alpha-2 adrenergic receptors: differential influence on Na+ versus guanylylnucleotide regulation.
Topics: Alkaloids; Animals; Cattle; Epinephrine; Guanylyl Imidodiphosphate; In Vitro Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium; Staurosporine; Yohimbine | 1992 |
Role of protein kinase-C in thymocyte apoptosis induced by irradiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Death; DNA; DNA Damage; In Vitro Techniques; Interphase; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes | 1992 |
Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Amino Acids; Animals; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Female; Glutamates; Guinea Pigs; Hydrolysis; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperidines; Polyamines; Protein Kinase C; Receptors, Amino Acid; Receptors, Cell Surface; Spermine; Staurosporine | 1992 |
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alanine; Alkaloids; Animals; Cell Membrane; Cells, Cultured; Colforsin; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; In Vitro Techniques; Mice; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1992 |
Regulation of LFA-1 avidity in human B cells. Requirements for dephosphorylation events for high avidity ICAM-1 binding.
Topics: Alkaloids; B-Lymphocytes; Cell Adhesion Molecules; Cells, Cultured; Ethers, Cyclic; Humans; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine | 1992 |
Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine.
Topics: Alkaloids; Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Phorbol 12,13-Dibutyrate; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Staurosporine; Terpenes; Thapsigargin | 1992 |
Nicotinic agonists, phorbol esters, and growth factors activate two extracellular signal-regulated kinases, ERK1 and ERK2, in bovine chromaffin cells.
Topics: Alkaloids; Animals; Cattle; Cells, Cultured; Chromaffin System; Dimethylphenylpiperazinium Iodide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Ganglionic Stimulants; Growth Substances; Immunoblotting; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Staurosporine | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Activation of phospholipase D by endothelin-1 and other pharmacological agents in rabbit iris sphincter smooth muscle.
Topics: Alkaloids; Animals; Endothelins; Enzyme Activation; GTP-Binding Proteins; In Vitro Techniques; Iris; Kinetics; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phospholipase D; Phospholipids; Rabbits; Receptors, Endothelin; Signal Transduction; Staurosporine; Type C Phospholipases | 1992 |
The protein kinase C activators, phorbol 12-myristate,13-acetate and phorbol 12,13-dibutyrate, are convulsant in the pico-nanomolar range in mice.
Topics: Alkaloids; Animals; Behavior, Animal; Convulsants; Enzyme Activation; Injections, Intraventricular; Male; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Seizures; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Ca2+ ionophore and phorbol ester stimulate diacylglycerol formation and phosphatidylcholine hydrolysis in rat parotid acinar cells.
Topics: Alkaloids; Animals; Calcimycin; Choline; Diglycerides; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Hydrolysis; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Phosphatidylcholines; Rats; Rats, Inbred Strains; Staurosporine | 1992 |
Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3.
Topics: Alkaloids; Ammonium Chloride; CD4 Antigens; Chloroquine; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Monensin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Radioimmunoprecipitation Assay; Staurosporine; T-Lymphocytes | 1992 |
Respiratory burst induced by phorbol ester in the presence of tautomycin, a novel inhibitor of protein phosphatases.
Topics: Alkaloids; Animals; Antifungal Agents; Cells, Cultured; Dogs; Echinomycin; Ethers, Cyclic; Hydrogen Peroxide; Nitroblue Tetrazolium; Okadaic Acid; Phorbol 12,13-Dibutyrate; Pyrans; Respiratory Burst; Spiro Compounds; Staurosporine | 1992 |
Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules.
Topics: Alkaloids; Antifungal Agents; Carbazoles; CD4 Antigens; Down-Regulation; Ethers, Cyclic; Indole Alkaloids; Okadaic Acid; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrans; Receptors, Transferrin; Spiro Compounds; Staurosporine | 1992 |
Intracellular Ca2+ mobilization and not calcium influx promotes phorbol ester-stimulated thromboxane A2 synthesis in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Cytosol; Drug Synergism; Humans; Membrane Lipids; Phorbol 12,13-Dibutyrate; Phospholipids; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1992 |
Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Bumetanide; Carrier Proteins; Endothelins; Isoquinolines; Male; Membrane Proteins; Ouabain; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rubidium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine | 1991 |
Bradykinin evoked depolarization of a novel neuroblastoma x DRG neurone hybrid cell line (ND7/23).
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cell Membrane; Cells, Cultured; Cytosol; Evoked Potentials; Ganglia, Spinal; Hybrid Cells; Inositol Phosphates; Ionomycin; Membrane Potentials; Neuroblastoma; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Staurosporine | 1991 |
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; CD4 Antigens; Cyclic AMP; Down-Regulation; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1991 |
Modulation of rat skeletal muscle chloride channels by activators and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Chloride Channels; Chlorides; Isoquinolines; Male; Membrane Proteins; Muscles; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetrahydropapaveroline | 1991 |
Activation of protein kinase-C inhibits vitamin D receptor gene expression.
Topics: Alkaloids; Animals; Blotting, Northern; Blotting, Southern; Calcimycin; Cell Division; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Receptors, Calcitriol; Receptors, Steroid; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
Chloride channel regulation in the skeletal muscle of normal and myotonic goats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Membrane Permeability; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Electric Conductivity; Female; Goats; Ion Channels; Isoquinolines; Male; Membrane Potentials; Muscles; Myotonia; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; Tetrahydropapaveroline | 1991 |
Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization.
Topics: Alkaloids; Animals; Carbachol; Cattle; Ciliary Body; Diglycerides; Dinoprost; Enzyme Activation; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Staurosporine; Substance P | 1991 |
Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Concanavalin A; Cross-Linking Reagents; Diterpenes; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Isoquinolines; Kinetics; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Phytohemagglutinins; Piperazines; Precipitin Tests; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C and phospholipase C in adenosine receptor-mediated relaxation in coronary artery.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Animals; Coronary Vessels; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Receptors, Purinergic; Staurosporine; Swine; Type C Phospholipases | 1991 |
Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?
Topics: Alkaloids; Animals; Calcium; Coronary Vessels; Enzyme Activation; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Staurosporine; Substrate Specificity; Swine; Time Factors | 1991 |
Protein kinase C is not involved in alpha 1-adrenoceptor-mediated positive inotropic effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electric Conductivity; Hydrolysis; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1991 |
Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Calcium; Enzyme Activation; Isoquinolines; Lymphocyte Activation; Mice; Mice, Inbred DBA; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperazines; Protein Kinase C; Staurosporine; Time Factors | 1991 |
Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C.
Topics: Alkaloids; Animals; Carcinogens; Cartilage; Cattle; Dinoprostone; Diterpenes; Down-Regulation; Enzyme Activation; Interleukin-1; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Proteoglycans; Staurosporine; Terpenes | 1991 |
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Blood Platelets; Bombesin; Collagen; DNA; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblasts; Humans; Indoles; Maleimides; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Platelet Aggregation; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Thymidine; Vimentin | 1991 |
Enhanced contractile effect of phorbol dibutyrate in portal veins from hypertensive rats.
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Portal Vein; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Staurosporine | 1991 |
Inhibition of the M current in NG 108-15 neuroblastoma x glioma hybrid cells.
Topics: Alkaloids; Animals; Bradykinin; Hybrid Cells; Membrane Potentials; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Xanthines | 1991 |
Inhibition of protein kinase C by staurosporine increases estrogen secretion by rat Sertoli cells.
Topics: Alkaloids; Animals; Cells, Cultured; Drug Antagonism; Estradiol; Follicle Stimulating Hormone; In Vitro Techniques; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Radioimmunoassay; Rats; Rats, Inbred Strains; Sertoli Cells; Staurosporine | 1991 |
Elevated cytosolic Ca2+ activates phospholipase D in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Humans; In Vitro Techniques; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phospholipase D; Platelet Activation; Staurosporine; Thrombin | 1991 |
Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate.
Topics: Alkaloids; Animals; Carbachol; Gastric Fundus; Male; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Staurosporine | 1991 |
Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Topics: Alkaloids; Animals; Antigens; Arachidonic Acids; Calcimycin; Carbazoles; Cell Line; Cell Membrane; Cells, Cultured; Dexamethasone; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macrophages; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Serum Albumin, Bovine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carcinogens; Cell Adhesion; Colorimetry; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Isoquinolines; Lactams; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Reproducibility of Results; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Protein kinase C and vascular smooth muscle contractility: effects of inhibitors and down-regulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Depression, Chemical; Dogs; Down-Regulation; Female; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Staurosporine; Vasoconstriction | 1991 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Thrombin and phorbol ester stimulate inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase in human platelets.
Topics: Alkaloids; Blood Platelets; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Inositol Phosphates; Inositol Polyphosphate 5-Phosphatases; Nucleotides; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium Chloride; Protein Kinase C; Staurosporine; Thrombin | 1990 |
The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase C.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cytosol; Ibotenic Acid; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, AMPA; Receptors, Neurotransmitter; Staurosporine | 1990 |
Subtype-selective regulation of beta adrenergic receptor-adenylyl cyclase coupling by phorbol esters in 3T3-L1 fibroblasts.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Cyclic AMP; Fibroblasts; Glucocorticoids; Isoproterenol; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Propanolamines; Protein Kinase C; Receptors, Adrenergic, beta; Staurosporine | 1990 |
Protein kinase C-mediated formation of phosphatidylinositol 3,4-bisphosphate in human platelets.
Topics: Alkaloids; Blood Platelets; Chromatography, High Pressure Liquid; Enzyme Activation; Humans; Phorbol 12,13-Dibutyrate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase C; Staurosporine; Thrombin | 1990 |
Evidence for involvement of protein kinase C and cyclic adenosine 3',5' monophosphate-dependent protein kinase in the 1,25-dihydroxy-vitamin D3-mediated rapid stimulation of intestinal calcium transport, (transcaltachia).
Topics: Alkaloids; Animals; Biological Transport; Calcitriol; Calcium; Chickens; Colforsin; Cyclic AMP; Duodenum; Intestinal Mucosa; Intestines; Kinetics; Male; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Vitamin D Deficiency | 1990 |
Evidence for involvement of protein kinase C in the cellular response to interferon alpha.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; DNA-Binding Proteins; Gene Expression; HeLa Cells; In Vitro Techniques; Interferon Type I; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Staurosporine; Transcription, Genetic; Vesicular stomatitis Indiana virus; Virus Replication | 1990 |
Expression, purification, and characterization of protein kinase C-epsilon.
Topics: Alkaloids; Animals; Cell Line; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Diglycerides; DNA; Enzyme Activation; Insect Viruses; Insecta; Isoenzymes; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Plasmids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 1990 |
[Ca2+], not diacylglycerol, is the primary regulator of sustained swine arterial smooth muscle contraction.
Topics: Alkaloids; Animals; Arteries; Calcium; Diglycerides; Endothelins; Glycerides; Histamine; Muscle, Smooth, Vascular; Myosins; Osmolar Concentration; Peptides; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Second Messenger Systems; Staurosporine; Swine; Time Factors; Vasoconstriction | 1990 |
The effect of protein kinase-C inhibition on insulin receptor phosphorylation.
Topics: Alkaloids; Cell Line; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Insulin; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate; Trypsin | 1990 |
Selectivity of protein kinase inhibitors in human intact platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Carrier Proteins; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Tamoxifen | 1990 |
Protein kinase C-mediated contractile responses of arteries from diabetic rats.
Topics: Alkaloids; Animals; Aorta, Thoracic; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Verapamil | 1990 |
Phorbol ester-induced stress and myosin light chain phosphorylation in swine carotid medial smooth muscle.
Topics: Alkaloids; Animals; Calcium; Drug Interactions; Enzyme Activation; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine | 1990 |
Resiniferatoxin, a potent capsaicin-like stimulator of peripheral nociceptors in the neonatal rat tail in vitro.
Topics: Alkaloids; Animals; Animals, Newborn; Bradykinin; Capsaicin; Diterpenes; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nociceptors; Peripheral Nerves; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred Strains; Regional Blood Flow; Staurosporine; Tail | 1990 |
Agonist-induced ADP-ribosylation of a cytosolic protein in human platelets.
Topics: Adenosine Diphosphate Ribose; Alkaloids; Blood Platelets; Blood Proteins; Cell Membrane Permeability; Cholera Toxin; Cytosol; Humans; In Vitro Techniques; Kinetics; Molecular Weight; NAD; Phorbol 12,13-Dibutyrate; Staurosporine; Thrombin | 1990 |
Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated wi
Topics: Alkaloids; Blood; Cell Division; Cell Line; Down-Regulation; Enzyme Activation; Growth Hormone; Humans; Kinetics; Lymphocytes; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Somatotropin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte.
Topics: Alkaloids; Animals; Arginine Vasopressin; Biological Clocks; Calcium; In Vitro Techniques; Liver; Male; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Stimulation, Chemical; Time Factors | 1990 |
Characterization of specific [3H]dimethylstaurosporine binding to protein kinase C.
Topics: Alkaloids; Animals; Binding, Competitive; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tritium | 1990 |
Evidence for a protein kinase C-directed mechanism in the phorbol diester-induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine.
Topics: Alkaloids; Animals; Bucladesine; Cell Line; Choline; Colforsin; Diglycerides; Embryo, Mammalian; Fibroblasts; Glycerides; Glycerophospholipids; Hydrolysis; Myristic Acid; Myristic Acids; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Phospholipases; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms. Evidence for a pathway that does not involve phosphorylation of the 47-kDa protein.
Topics: Alkaloids; Animals; Diglycerides; Diterpenes; Glycerides; Guinea Pigs; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Proteins; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Comparative effects of endothelin and phorbol 12-13 dibutyrate in rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endothelins; Endothelium, Vascular; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Phenylephrine; Phloretin; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction | 1989 |
A role for protein kinase C in the electrically evoked release of [3H] gamma-aminobutyric acid in rabbit caudate nucleus.
Topics: Alkaloids; Animals; Caudate Nucleus; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Staurosporine | 1989 |
Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C.
Topics: Alkaloids; Amino Acids; Animals; Carbachol; Enzyme Activation; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Ibotenic Acid; Male; Norepinephrine; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Quisqualic Acid; Rats; Rats, Inbred Strains; Staurosporine | 1988 |
Bradykinin activates peripheral capsaicin-sensitive fibres via a second messenger system.
Topics: Alkaloids; Animals; Animals, Newborn; Bradykinin; Capsaicin; Nociceptors; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Spinal Cord; Staurosporine; Tail | 1988 |
Rapid screening method for inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomycetales; Alkaloids; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Isoflavones; Isoquinolines; Leukemia, Myeloid; Lyngbya Toxins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1988 |
Asialoglycoprotein receptor phosphorylation and receptor-mediated endocytosis in hepatoma cells. Effect of phorbol esters.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Asialoglycoprotein Receptor; Endocytosis; Liver Neoplasms, Experimental; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Protein Kinase C; Receptors, Immunologic; Staurosporine; Subcellular Fractions | 1988 |
Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C.
Topics: Alkaloids; Animals; Bradykinin; Capsaicin; Enzyme Inhibitors; In Vitro Techniques; Membrane Potentials; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Spinal Cord; Staurosporine | 1988 |
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
Topics: Alkaloids; Animals; Binding, Competitive; Brain; Cell Division; HeLa Cells; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Binding; Protein Kinase C; Rats; Staurosporine | 1986 |
Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; GTP-Binding Proteins; Hippocampus; Neural Inhibition; Norepinephrine; Phorbol 12,13-Dibutyrate; Presynaptic Terminals; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Staurosporine; Synapses; Synaptic Transmission; Tetrodotoxin | 1993 |
Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Endotoxins; Enzyme Activation; Gene Expression Regulation; Humans; Isoquinolines; Monocytes; Naphthalenes; Naphthol AS D Esterase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1993 |
Evidence that prostaglandin E2 can block calcium-activated 86Rb efflux from rat brain synaptosomes via a protein kinase C-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Calcium Channel Blockers; Charybdotoxin; Cyclic AMP; Dinoprostone; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Prosencephalon; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rubidium; Scorpion Venoms; Staurosporine; Sulfonamides; Synaptosomes; Thionucleotides | 1994 |
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzoquinones; Cell Cycle Proteins; Cell Line; Ceramides; Chlorocebus aethiops; Diglycerides; DNA Primers; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Kinetics; Lactams, Macrocyclic; Molecular Sequence Data; Muromonab-CD3; Mutagenesis, Site-Directed; Naphthalenes; Phorbol 12,13-Dibutyrate; Point Mutation; Polycyclic Compounds; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogene Proteins p21(ras); Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1994 |
Effects of protein kinase C activator and inhibitor on adrenal catecholamine release in response to splanchnic nerve stimulation in anesthetized dogs.
Topics: Adrenal Glands; Alkaloids; Animals; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Epinephrine; Female; Male; Neomycin; Norepinephrine; Phorbol 12,13-Dibutyrate; Polymyxins; Protein Kinase C; Splanchnic Nerves; Staurosporine | 1994 |
Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Coronary Vasospasm; Disease Models, Animal; Histamine; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Serotonin; Staurosporine; Swine; Swine, Miniature | 1994 |
Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alkaloids; Animals; Chloride Channels; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Guinea Pigs; Myocardium; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Ventricular Function | 1995 |
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Topics: Alkaloids; Breast Neoplasms; Cell Membrane; Cytosol; Humans; Immunoblotting; Indoles; Naphthalenes; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Topics: Alkaloids; Angiotensin II; Animals; Aorta, Thoracic; Drug Tolerance; Endothelins; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Phenylephrine; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rabbits; Serotonin; Staurosporine; Vasoconstriction | 1995 |
Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells.
Topics: Alkaloids; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Data Interpretation, Statistical; Down-Regulation; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Isoenzymes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Stress, Mechanical | 1995 |
Phorbol esters elicit Ca(2+)-dependent delayed contractions in diabetic rat aorta.
Topics: Alkaloids; Animals; Aorta; Body Weight; Calcium; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organ Size; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Role of protein kinase C in relationship between Ca2+ and contractile elements in rat alpha-toxin-permeabilized mesenteric artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bacterial Toxins; Calcium; Cell Membrane Permeability; Enzyme Activation; Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1995 |
Kinase activation and smooth muscle contraction in the presence and absence of calcium.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Calcium; Carotid Arteries; Cattle; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Phorbol 12,13-Dibutyrate; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Serotonin; Staurosporine; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Role of protein kinase C in nonsensitized and passively sensitized human isolated bronchial smooth muscle.
Topics: Alkaloids; Allergens; Asthma; Bronchi; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Immunization, Passive; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Staurosporine; Time Factors; Verapamil | 1995 |
Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies.
Topics: Alkaloids; CD11 Antigens; CD18 Antigens; Cell Aggregation; Ethers, Cyclic; Humans; Muromonab-CD3; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphothreonine; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Staurosporine; T-Lymphocyte Subsets; Threonine | 1995 |
A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Enzyme Activation; Isoquinolines; Kidney Pelvis; Male; Naphthalenes; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Staurosporine | 1995 |
Protein kinase C differently regulates quisqualate- and 1S,3R-trans aminocyclopentane dicarboxylate-induced phosphoinositide hydrolysis during in vitro development of hippocampal neurons.
Topics: Alkaloids; Animals; Carbachol; Cells, Cultured; Cycloleucine; Enzyme Activation; Hippocampus; Hydrolysis; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Quisqualic Acid; Rats; Staurosporine | 1995 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Protein kinase C activates the non-selective cation channel in the rabbit portal vein.
Topics: Alkaloids; Animals; Chlorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Nicardipine; Niflumic Acid; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Portal Vein; Protein Kinase C; Rabbits; Staurosporine; Virulence Factors, Bordetella | 1993 |
The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channels; Dihydropyridines; Female; Growth Hormone; Ion Channel Gating; Isoquinolines; Luteinizing Hormone; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1993 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine | 1995 |
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Analysis of Variance; Animals; Calcium; Cattle; Cells, Cultured; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression Regulation, Enzymologic; Nucleic Acid Hybridization; Parathyroid Glands; Parathyroid Hormone; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; RNA, Ribosomal, 18S; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Proteolytic release of human angiotensin-converting enzyme expressed in Chinese hamster ovary cells is enhanced by phorbol ester.
Topics: Alkaloids; Animals; Cell Membrane; CHO Cells; Cricetinae; Endopeptidases; Humans; Kinetics; Peptidyl-Dipeptidase A; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Protein Processing, Post-Translational; Recombinant Proteins; Staurosporine; Transfection | 1995 |
Mutual antagonistic interactions between the thyrotropin (adenosine 3',5'-monophosphate) and protein kinase C/epidermal growth factor (tyrosine kinase) pathways in cell proliferation and differentiation of cultured human thyroid follicles.
Topics: Alkaloids; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Epidermal Growth Factor; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein-Tyrosine Kinases; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
Involvement of inositol 1,4,5-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery.
Topics: Alkaloids; Animals; Calcium; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Pulmonary Artery; Staurosporine; Swine; Thrombin; Vasoconstriction; Verapamil | 1995 |
Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells.
Topics: Alkaloids; Cells, Cultured; Colforsin; Endothelium, Vascular; Histamine; Humans; Hydrolysis; Indoles; Nitroprusside; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Receptors, Histamine H1; Sodium Fluoride; Staurosporine; Umbilical Veins | 1994 |
Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx.
Topics: Alkaloids; Animals; Calcium; Cell Line; Culture Media, Serum-Free; Cytoplasm; Down-Regulation; Edetic Acid; Egtazic Acid; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Phorbol 12,13-Dibutyrate; Pituitary Gland; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1994 |
Treatment with the anabolic steroid, nandrolone, reduces vasoconstrictor responses in rabbit arteries.
Topics: Alkaloids; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nandrolone; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Serotonin; Staurosporine; Vasoconstriction | 1994 |
The regulation of sodium-dependent transport of anionic amino acids in cultured human fibroblasts.
Topics: Adolescent; Alkaloids; Arginine; Aspartic Acid; Becaplermin; Biological Transport; Bradykinin; Cells, Cultured; Down-Regulation; Enzyme Activation; Fibroblasts; Humans; Male; Membrane Potentials; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-sis; Skin; Sodium; Staurosporine | 1994 |
Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha.
Topics: Alkaloids; Base Sequence; Cells, Cultured; Cyclosporine; DNA; Humans; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Interleukin-2; Staurosporine; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1994 |
Cytochalasin inhibition of slow tension increase in rat aortic rings.
Topics: Alkaloids; Animals; Aorta, Thoracic; Cytochalasin B; Cytochalasins; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Temperature | 1994 |
Protracted treatment with phorbol ester modulates J-7 human hepatoma-cell-induced aggregation and coagulation of human platelet-rich plasma.
Topics: Alkaloids; Blood Coagulation; Blood Platelets; Carcinoma, Hepatocellular; Cell Adhesion; Concanavalin A; Extracellular Matrix Proteins; Factor IX; Factor VII; Heparin; Hirudins; Humans; Liver Neoplasms; Phorbol 12,13-Dibutyrate; Platelet Aggregation; Staurosporine; Tumor Cells, Cultured | 1994 |
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine | 1994 |
Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells.
Topics: Alkaloids; Aluminum Compounds; Animals; Biological Transport; Cell Line; Cell Membrane; Cell Polarity; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Endoplasmic Reticulum; Enzyme Activation; Epithelium; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Hemagglutinins; In Vitro Techniques; Kidney; Membrane Glycoproteins; Phorbol 12,13-Dibutyrate; Phosphoproteins; Staurosporine; Viral Envelope Proteins | 1994 |
Phorbol dibutyrate induces contractions in bovine cerebral arteries by an extracellular calcium-independent mechanism.
Topics: Alkaloids; Animals; Calcium; Cattle; Cerebral Arteries; Down-Regulation; Drug Interactions; Egtazic Acid; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Serotonin; Staurosporine; Vasoconstriction | 1993 |
Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Endopeptidases; Enzyme Activation; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Transfection | 1993 |
Facilitatory effect of phorbol ester on 2-deoxyglucose uptake in rat hippocampal slices.
Topics: Alkaloids; Animals; Carbachol; Carbazoles; Deoxyglucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Indole Alkaloids; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Wistar; Staurosporine | 1993 |
Selective inhibition by H7 and staurosporin of phorbol ester responses in U-937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Antigens, CD; Calcium; CD18 Antigens; Cell Adhesion; Drug Antagonism; Enzyme Activation; Humans; Isoquinolines; Macrophage-1 Antigen; Molecular Sequence Data; Monocytes; Neoplasm Proteins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Signal Transduction; SRS-A; Staurosporine; Tumor Cells, Cultured | 1993 |
Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils.
Topics: Alkaloids; Cell Adhesion; Complement C5a; Endothelium, Vascular; Humans; In Vitro Techniques; Indoles; Macrophage-1 Antigen; Maleimides; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Up-Regulation | 1994 |
Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Alkaloids; Animals; Enzyme Activation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Pyridazines; Rats; Rats, Wistar; Serotonin; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1994 |
Desensitization of cholecystokininB receptors in GH3 cells.
Topics: Alkaloids; Calcium; Drug Tolerance; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Marine Toxins; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Pituitary Neoplasms; Protein Kinase C; Receptors, Cholecystokinin; Sincalide; Staurosporine; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidines; Isoquinolines; Perfusion; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pinacidil; Piperazines; Protein Kinase C; Rabbits; Staurosporine; Ventricular Fibrillation | 1993 |
Staurosporine up-regulates the expression of phorbol dibutyrate binding sites in human platelets.
Topics: Alkaloids; Binding Sites; Blood Platelets; Caenorhabditis elegans Proteins; Carrier Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Humans; Monocytes; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Drug; Staurosporine; Subcellular Fractions; Temperature; Up-Regulation | 1994 |
Oxidative stress causes a protein kinase C-independent increase of paracellular permeability in an in vitro epithelial model.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Cell Line; Dogs; Electrophysiology; Epithelium; Hydrogen Peroxide; In Vitro Techniques; Kidney; Mannitol; Oxidation-Reduction; Permeability; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Superoxides; Time Factors | 1993 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
1,25-Dihydroxyvitamin D3 and macrophage colony-stimulating factor-1 synergistically phosphorylate talin.
Topics: Alkaloids; Animals; Calcitriol; Cell Line; Drug Synergism; Genistein; Isoflavones; L Cells; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Talin; Tetradecanoylphorbol Acetate | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Adenosine reduces the potassium conductance of guinea pig submucosal plexus neurons by activating protein kinase A.
Topics: 2-Chloroadenosine; Adenosine; Alkaloids; Animals; Cadmium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Guinea Pigs; Membrane Potentials; Neurons; Phorbol 12,13-Dibutyrate; Potassium; Staurosporine; Submucous Plexus | 1993 |
Inhibition of the calcium store-operated calcium entry pathway by chemotactic peptide and by phorbol ester develops gradually and independently along differentiation of HL60 cells.
Topics: Alkaloids; Benzophenanthridines; Biological Transport; Calcium; Cell Differentiation; Humans; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
H7-resistant protein kinase C substrates in two-dimensional gels of proestrous rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electrophoresis, Gel, Two-Dimensional; Estrus; Female; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substrate Specificity | 1993 |
Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; Heart Ventricles; Hydrolysis; Indoles; Isoquinolines; Male; Myocardial Contraction; Myocardium; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Prazosin; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha; Staurosporine | 1993 |
Regulation of resting ionic conductances in frog skeletal muscle.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Chlorides; Colforsin; Electric Conductivity; Electrophysiology; Enzyme Activation; Muscles; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rana esculenta; Staurosporine | 1993 |
Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Indoles; Isoquinolines; Lung; Male; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes | 1993 |
Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons.
Topics: Alkaloids; Animals; Barium; Calcium Channels; Electric Conductivity; Ganglia, Sympathetic; GTP-Binding Proteins; Kinetics; Neurons; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rana catesbeiana; Staurosporine | 1993 |
Type-specific stimulation of adenylylcyclase by protein kinase C.
Topics: Adenylyl Cyclases; Alkaloids; Cells, Cultured; Cyclic AMP; DNA; Enzyme Activation; Humans; Isoenzymes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.
Topics: Alkaloids; Animals; Benzophenanthridines; Bucladesine; Diglycerides; Exocytosis; In Vitro Techniques; Lacrimal Apparatus; Male; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Cell Membrane; Chorionic Gonadotropin; Cyclic AMP; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Activation; GTP-Binding Proteins; Humans; Isoenzymes; Kidney; Kinetics; Macromolecular Substances; Mice; Moths; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Rats; Receptors, Bombesin; Receptors, Dopamine D2; Receptors, LH; Receptors, Neurotransmitter; Recombinant Proteins; Rhodopsin; Signal Transduction; Staurosporine; Transfection; Virulence Factors, Bordetella | 1993 |
Studies on regulation of the ascorbic acid transporter in a cell line derived from rabbit non-pigmented ciliary epithelium.
Topics: Alkaloids; Animals; Ascorbic Acid; Biological Transport, Active; Bucladesine; Carrier Proteins; Cell Line; Ciliary Body; Epithelium; Phloretin; Phorbol 12,13-Dibutyrate; Rabbits; Sodium; Staurosporine | 1993 |
Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis.
Topics: Alkaloids; Cells, Cultured; Fluorometry; Humans; Isoelectric Focusing; Keratinocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Psoriasis; Reference Values; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts.
Topics: Alkaloids; Animals; Bradykinin; Calcimycin; Cell Membrane; Cells, Cultured; Dinoprostone; Enzyme Activation; Hydrocortisone; Indomethacin; Mice; Osteoblasts; Phorbol 12,13-Dibutyrate; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
A protein kinase inhibitor, staurosporine, enhances the expression of phorbol dibutyrate binding sites in human polymorphonuclear leucocytes.
Topics: Alkaloids; Biological Transport; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Compartmentation; Histones; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Receptors, Drug; Staurosporine; Subcellular Fractions | 1993 |
The effects of beta-phorbol-12,13 dibutyrate on agonist-induced increases in [Ca2+]i in N1E-115 cells. Differential modulation of responses to angiotensin II and bradykinin.
Topics: Alkaloids; Angiotensin II; Animals; Bradykinin; Calcium; Down-Regulation; Enzyme Activation; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
Both activators and inhibitors of protein kinase C promote the inhibition of phenylephrine-induced [Ca2+]i oscillations in single intact rat hepatocytes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Benzophenanthridines; Calcium; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Maleimides; Molecular Sequence Data; Oligopeptides; Phenanthridines; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1995 |
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Coronary Vasospasm; Cytosol; Enzyme Activation; Histamine; Interleukin-1; Male; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Ryanodine; Sarcoplasmic Reticulum; Serotonin; Sphingosine; Staurosporine; Swine; Terpenes; Thapsigargin | 1996 |
Calcium-and phorbol ester-dependent calponin phosphorylation in homogenates of swine carotid artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calponins; Carotid Arteries; Electrophoresis; Enzyme Inhibitors; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine | 1996 |
Impairment of protein kinase C activity in twitcher Schwann cells in vitro.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Glia Maturation Factor; Growth Inhibitors; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Pituitary Gland; Platelet-Derived Growth Factor; Protein Kinase C; Recombinant Proteins; Schwann Cells; Staurosporine; Tissue Extracts; Transforming Growth Factor beta | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
Muscarinic autoinhibition of acetylcholine release in mouse atria is not transduced through cyclic AMP or protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenylyl Cyclases; Animals; Atrial Function; Atropine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Heart; Heart Atria; In Vitro Techniques; Male; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Muscarinic; Second Messenger Systems; Staurosporine | 1996 |
Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro.
Topics: Alkaloids; Animals; Dogs; Enzyme Activation; Enzyme Inhibitors; Hot Temperature; In Vitro Techniques; Male; Nerve Fibers; Neural Conduction; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sensory Receptor Cells; Spermatic Cord; Staurosporine; Testis | 1996 |
Regulation and metabolic role of phospholipase D activity in human thyroid and cultured dog thyrocytes.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium-Transporting ATPases; Cells, Cultured; Cytidine Monophosphate; Dogs; Enzyme Inhibitors; Glycerophospholipids; Humans; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Thapsigargin; Thyroid Gland; Thyrotropin; Tritium | 1996 |
The role of protein kinase C in nicotinic responses of bovine chromaffin cells.
Topics: Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Nicotinic; Recombinant Proteins; Staurosporine; Tyrosine 3-Monooxygenase | 1996 |
Protein kinase C modulates flow-initiated contraction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Regional Blood Flow; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 1996 |
Increased probability of GABA release during withdrawal from morphine.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Antagonists; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Interneurons; Morphine; Nerve Tissue Proteins; Organophosphorus Compounds; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Picrotoxin; Receptors, GABA-A; Salicylamides; Serotonin; Signal Transduction; Staurosporine; Strychnine; Substance Withdrawal Syndrome; Tegmentum Mesencephali; Thionucleotides | 1997 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Extracellular Ca2+-dependent contractile action of phorbol 12,13-dibutyrate on gall bladder from guinea pig.
Topics: Animals; Calcium; Calcium Channel Blockers; Drug Synergism; Gallbladder; Guinea Pigs; Isometric Contraction; Male; Nifedipine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Staurosporine; Verapamil | 1997 |
Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Isoproterenol; Naphthalenes; Phorbol 12,13-Dibutyrate; Pigment Epithelium of Eye; Protein Kinase C; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Staurosporine | 1997 |
The promoting effects of bFGF and astrocyte extracellular matrix on process outgrowth by adult human oligodendrocytes are mediated by protein kinase C.
Topics: Astrocytes; Cells, Cultured; Enzyme Inhibitors; Extracellular Matrix; Fibroblast Growth Factor 2; Humans; Naphthalenes; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine | 1997 |
Muscarinic autoinhibition and modulatory role of protein kinase C in acetylcholine release from the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Benzoquinones; Chromatography, High Pressure Liquid; Electric Stimulation; Estrenes; Guinea Pigs; Ileum; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Melitten; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Pyrrolidinones; Quinacrine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases | 1997 |
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents | 1997 |
Arachidonic acid inhibits capacitative calcium entry in rat thymocytes and human neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Cytochrome P-450 Enzyme System; Electric Conductivity; Fatty Acids, Unsaturated; Humans; Neutrophils; Oxidoreductases; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thymus Gland | 1997 |
Involvement of protein kinase C in the supersensitivity to 5-HT caused by oxidized low-density lipoproteins.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Enzyme Inhibitors; In Vitro Techniques; Lipoproteins, LDL; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rabbits; Serotonin; Staurosporine | 1997 |
Lipid-dependent modulation of Ca2+ availability in isolated mossy fiber nerve endings.
Topics: Acetylcholine; Animals; Arachidonic Acid; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Lipids; Mossy Fibers, Hippocampal; Norepinephrine; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Staurosporine | 1997 |
Effects of phorbol-12,13-dibutyrate and protein kinase C inhibitors on Mn(2+)-dependent norepinephrine-induced contractions involving increase in Mn2+ sensitivity in Ca(2+)-depleted vas deferens of the guinea pig.
Topics: Animals; Calcium; Enzyme Inhibitors; Escin; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Magnesium; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Vas Deferens | 1997 |
Roles of PKA and PKC in regulation of Na+ pump activity in vascular smooth muscle cells.
Topics: Animals; Aorta; Arginine Vasopressin; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Homeostasis; Isoproterenol; Kinetics; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Staurosporine | 1997 |
Evidence that protein kinase C activation is involved in the excitatory and facilitatory effects of bradykinin on canine visceral nociceptors in vitro.
Topics: Adaptation, Physiological; Animals; Bradykinin; Dogs; Male; Neural Conduction; Nociceptors; Pain; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sensory Receptor Cells; Sensory Thresholds; Staurosporine; Temperature; Testis; Visceral Afferents | 1997 |
[Pharmacological studies on alterations in contractile reactivity in aortas isolated from experimental diabetic rats].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Nifedipine; Norepinephrine; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Rats, Wistar; Serotonin; Staurosporine; Streptozocin; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts.
Topics: Aged; Amyloid beta-Protein Precursor; Biopsy; Blotting, Northern; Blotting, Western; Carbazoles; Cells, Cultured; Female; Fibroblasts; Humans; Indoles; Isoenzymes; Male; Middle Aged; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C-alpha; Skin; Staurosporine | 1998 |
Kainate receptor modulation of GABA release involves a metabotropic function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carcinogens; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Second Messenger Systems; Sodium; Staurosporine; Sulfonamides; Tetraethylammonium; Tetrodotoxin; Thionucleotides; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
PKC activity modulates availability and long openings of L-type Ca2+ channels in A7r5 cells.
Topics: Alkaloids; Animals; Aorta; Benzophenanthridines; Calcium Channels; Calcium Channels, L-Type; Cell Line; Enzyme Activation; Enzyme Inhibitors; Ion Channel Gating; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Okadaic Acid; Patch-Clamp Techniques; Phenanthridines; Phorbol 12,13-Dibutyrate; Probability; Protein Kinase C; Rats; Staurosporine | 1998 |
Protein kinase C--catalyzed calponin phosphorylation in swine carotid arterial homogenate.
Topics: Animals; Antiemetics; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Calmodulin-Binding Proteins; Calponins; Carcinogens; Carotid Arteries; Chelating Agents; Diglycerides; Egtazic Acid; Electrophoresis; Enzyme Inhibitors; Imidazoles; Microfilament Proteins; Okadaic Acid; Organ Culture Techniques; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Staurosporine; Sulfonamides; Swine; Trifluoperazine; Vasodilator Agents | 1998 |
A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Aorta; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cricetinae; Indoles; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nifedipine; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium; Ryanodine; Staurosporine; Vasoconstrictor Agents | 1998 |
Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amino Acid Sequence; Animals; Drug Interactions; Drug Resistance; Glomerular Mesangium; Inositol Phosphates; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phorbol 12,13-Dibutyrate; Phosphorylation; Precipitin Tests; Protein Kinase C; Receptors, Thromboxane; Recombinant Proteins; Serine; Staurosporine; Thromboxane A2 | 1998 |
Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Corpus Luteum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Ionomycin; Ionophores; Lipoproteins, LDL; Luteal Phase; Phorbol 12,13-Dibutyrate; Progesterone; Prolactin; Protein Kinase C; Staurosporine; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; DNA Fragmentation; Enzyme Inhibitors; G2 Phase; Genistein; Humans; Neoplasm Proteins; Paclitaxel; Phorbol 12,13-Dibutyrate; Proto-Oncogene Proteins c-bcl-2; S Phase; Staurosporine; Tumor Cells, Cultured | 1995 |
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents | 1998 |
Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes.
Topics: Animals; Caffeine; Calcium-Transporting ATPases; Contractile Proteins; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Magnesium; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sarcolemma; Sarcoplasmic Reticulum; Staurosporine; Time Factors | 1998 |
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels; Carcinogens; Disinfectants; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Morphine; Nociceptors; omega-Conotoxin GVIA; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Staurosporine; Synapses | 1999 |
Redox modulation of intracellular free calcium concentration in thyroid FRTL-5 cells: evidence for an enhanced extrusion of calcium.
Topics: Animals; Barium; Calcium; Calcium-Transporting ATPases; Cell Line; Enzyme Activation; Hydrogen-Ion Concentration; Imidazoles; Membrane Potentials; Mercaptoethanol; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Binding; Protein Kinase C; Rats; Staurosporine; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Thapsigargin; Thimerosal; Thyroid Gland; Vanadates | 1999 |
Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Lactams; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reference Values; Solubility; Staurosporine | 1999 |
Phorbol ester modulation of active ion transport across the rabbit conjunctival epithelium.
Topics: Animals; Biological Transport, Active; Bumetanide; Chlorine; Conjunctiva; Culture Techniques; Enzyme Inhibitors; Female; Ion Transport; Male; Ouabain; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Effects of protein kinase C inhibitors on ethanol-induced contractions in isolated rat aorta.
Topics: Animals; Aorta; Enzyme Inhibitors; Ethanol; Male; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth, Vascular; Naphthalenes; Necrosis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reactive Oxygen Species; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
The involvement of protein kinase C in the regulation of choline cotransport in Limulus.
Topics: Animals; Arachidonic Acids; Biological Transport; Brain; Carcinogens; Carrier Proteins; Choline; Cholinergic Agents; Enzyme Inhibitors; Hemicholinium 3; Horseshoe Crabs; Nervous System; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Potassium Chloride; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Insulin modulation of cloned mouse NMDA receptor currents in Xenopus oocytes.
Topics: Animals; Brain; Cloning, Molecular; Enzyme Inhibitors; Female; Insulin; Membrane Potentials; meta-Aminobenzoates; Mice; Oocytes; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Protein-Tyrosine Kinases; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Salicylates; Staurosporine; Xenopus laevis | 1999 |
Effect of HIV-1 gp41 peptides on secretion of beta-amyloid precursor protein in human astroglial cell line, T98G.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; AIDS Dementia Complex; Amyloid beta-Protein Precursor; Astrocytes; Carcinogens; Cell Line; Culture Media, Conditioned; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation, Viral; HIV Envelope Protein gp41; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine | 1999 |
Dynamics of munc18-1 phosphorylation/dephosphorylation in rat brain nerve terminals.
Topics: Animals; Cyclosporine; Kinetics; Male; Munc18 Proteins; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phosphates; Phosphorylation; Prosencephalon; Proteins; Rats; Rats, Wistar; Recombinant Fusion Proteins; Staurosporine; Synaptosomes; Vesicular Transport Proteins | 2000 |
Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; CD59 Antigens; Cell Line; Complement Inactivator Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV Envelope Protein gp41; Humans; Immunodominant Epitopes; Lipopolysaccharides; Neuroglia; Neurons; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine | 2000 |
Possible contribution of protein kinase C in the effects of histamine on the visceral nociceptor activities in vitro.
Topics: Animals; Dogs; Enzyme Activation; Histamine; Histamine Antagonists; Hot Temperature; In Vitro Techniques; Male; Nociceptors; Phorbol 12,13-Dibutyrate; Protein Kinase C; Spermatic Cord; Staurosporine; Testis; Time Factors; Viscera | 2000 |
Hydrogen peroxide attenuates store-operated calcium entry and enhances calcium extrusion in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Down-Regulation; Enzyme Activation; Hydrogen Peroxide; Isoenzymes; Manganese; Membrane Potentials; Mercaptoethanol; Naphthalenes; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Rats; Sodium; Staurosporine; Thapsigargin; Thyroid Gland | 2000 |
Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries.
Topics: Animals; Cell Membrane; Cerebral Arteries; Enzyme Inhibitors; Feedback; Fetus; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Lactams; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Sheep; Signal Transduction; Staurosporine; Vasoconstriction | 2000 |
Activation of dopamine D(1)-like receptor causes phosphorylation of alpha(1)-subunit of Na(+),K(+)-ATPase in rat renal proximal tubules.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cell Line; Dopamine Agonists; Enzyme Inhibitors; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutation; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Enzyme Inhibitors; Heart Ventricles; Hypercholesterolemia; In Vitro Techniques; Male; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists.
Topics: Animals; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indoles; Interleukin-1; Interleukin-6; Luciferases; Maleimides; Naphthalenes; Osteoblasts; Parathyroid Hormone; Phorbol 12,13-Dibutyrate; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Effect of protein kinase C on guinea pig sperm acrosome reaction induced by progesterone.
Topics: Acrosome Reaction; Animals; Diglycerides; Guinea Pigs; Male; Phorbol 12,13-Dibutyrate; Progesterone; Protein Kinase C; Signal Transduction; Spermatozoa; Staurosporine | 2000 |
Acidosis inhibits gallbladder contraction mediated by protein kinase C activation.
Topics: Acidosis; Animals; Calcium; Calcium Chloride; Dinoprostone; Enzyme Activation; Extracellular Space; Gallbladder; Guinea Pigs; HEPES; Histamine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Staurosporine | 2001 |
Complestatin antagonizes the AMPA/kainate-induced neurotoxicity in cultured chick telencephalic neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chick Embryo; Chickens; Chlorophenols; Excitatory Amino Acid Antagonists; Kainic Acid; Neurons; Oligopeptides; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Staurosporine; Telencephalon; Time Factors | 2002 |
Human osteoblast-like cell proliferation induced by calcitonin-related peptides involves PKC activity.
Topics: Amyloid; Calcitonin; Calcitonin Receptor-Like Protein; Cell Division; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Islet Amyloid Polypeptide; Osteoblasts; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Calcitonin; Staurosporine | 2003 |
Prolactin signalling in porcine theca cells: the involvement of protein kinases and phosphatases.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Inositol Phosphates; Kinetics; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Progesterone; Prolactin; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Swine; Theca Cells; Vanadates | 2003 |
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings.
Topics: Acetylcholine; Adenosine; Amphibians; Animals; Binomial Distribution; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Evoked Potentials; Indoles; Maleimides; Monte Carlo Method; Nerve Endings; Neuromuscular Junction; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rana pipiens; Staurosporine; Synaptic Vesicles | 2003 |
Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.
Topics: Amiloride; Animals; Arachidonic Acids; Brefeldin A; Cytochrome P-450 Enzyme System; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Kidney Cortex; Kinetics; Male; Models, Biological; Nocodazole; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 2004 |
Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Shape; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C-alpha; Staurosporine; Vinblastine | 2007 |
Augmenting effect of serotonin on the voltage-dependent Ca2+ current and subsequently activated K+ current in Aplysia neurons.
Topics: Animals; Aplysia; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cholera Toxin; Enzyme Inhibitors; Guanosine Diphosphate; Large-Conductance Calcium-Activated Potassium Channels; Neurons; Okadaic Acid; Patch-Clamp Techniques; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Potassium Channels, Calcium-Activated; Protein Kinase C; Receptors, Serotonin; Serotonin; Signal Transduction; Staurosporine; Tetraethylammonium; Thionucleotides | 2007 |
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carbazoles; Cell Membrane; Chlorocebus aethiops; COS Cells; Diglycerides; Estrenes; HeLa Cells; HL-60 Cells; Humans; Indoles; Maleimides; Membranes; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Pyrrolidinones; Staurosporine | 2007 |
Involvement of protein kinase C and IP3-mediated Ca2+ release in activity modulation by paraoxon in snail neurons.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Gallic Acid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Molluscacides; Neurons; Paraoxon; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase Inhibitors; Snails; Staurosporine; Time Factors | 2007 |
Phorbol 12,13-dibutyrate-induced protein kinase C activation triggers sustained contracture in human myometrium in vitro.
Topics: Adult; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indoles; Myometrium; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tocolytic Agents; Uterine Contraction; Young Adult | 2017 |