phorbol 12,13-dibutyrate has been researched along with bryostatin 1 in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.88) | 18.7374 |
| 1990's | 21 (65.63) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Irie, K; Kamachi, H; Murakami, A; Nagai, H; Nakagawa, Y; Tanaka, K; Tokuda, H; Yanagita, RC | 1 |
| Grant, S; McCrady, C; Pettit, GR | 1 |
| Grant, S; Li, F; McCrady, CW; Pettit, GR | 1 |
| Basu, A; Lazo, JS | 1 |
| Blumberg, PM; Dell'Aquila, ML; Lewin, NE; Pettit, GR; Warren, BS | 1 |
| McCrady, CW; McVicar, DW; Merchant, RE | 1 |
| Hess, AD; Levine, BL; May, WS; Tyler, PG | 1 |
| Boise, L; Grant, S; Howe, C; McCrady, C; Pettit, GR; Turner, A; Westin, E | 1 |
| Grant, S; Howe, C; McCrady, CW; Pettit, GR; Staniswalis, J | 1 |
| Grant, S; Howe, C; McCrady, C; Pettit, GR | 1 |
| Akerlind, G; Akerman, KE; Heikkilä, J; Jalava, AM; Pettit, GR | 1 |
| Blumberg, PM; Herald, CL; Pettit, GR; Sako, T; Yuspa, SH | 1 |
| Fields, AP; May, WS; Pettit, GR | 1 |
| Blumberg, PM; Kamano, Y; Pettit, GR; Warren, BS | 1 |
| Blumberg, PM; Herald, CL; Pasti, G; Pettit, GR; Rivedal, E; Yuspa, SH | 1 |
| Pettit, GR; Ramsdell, JS; Tashjian, AH | 1 |
| Blumberg, PM; Dell'Aquila, ML; Herald, CL; Nguyen, HT; Pettit, GR | 1 |
| Pettit, GR; Smith, JB; Smith, L | 1 |
| Blumberg, PM; Bruns, JD; Kazanietz, MG; Lewin, NE | 1 |
| Blumberg, PM; Kazanietz, MG; Lewin, NE; Liu, HL; Milne, GW; Wang, S | 1 |
| Akompong, T; Schonhorn, JE; Wessling-Resnick, M | 1 |
| Barbacid, M; Blumberg, PM; Bruns, JD; Bustelo, XR; Kazanietz, MG; Kolch, W; Mischak, H; Pettit, GR; Wong, G | 1 |
| Bond, J; Dawson, T; Eccles, N; Wynford-Thomas, D | 1 |
| Bignami, GS; Davis, DE; Grothaus, PG; Kraft, AS; Rustagi, P; Wagner, F | 1 |
| Basu, A; Saijo, N; Weixel, K | 1 |
| Matthews, SA; Pettit, GR; Rozengurt, E | 1 |
| Chelliah, J; Freemerman, AJ; Grant, S; Jarvis, WD; Wu-Pong, S | 1 |
| Basu, A | 1 |
| Beheshti, M; Bhattacharyya, D; Blumberg, PM; Bögi, K; Garfield, SH; Hughes, KM; Lorenzo, PS; Pettit, GR | 1 |
| Blumberg, PM; Fang, TW; Lewin, NE; Marquez, VE; Van Lint, J; Wang, QJ; Yang, D | 1 |
| Basu, A; Huang, J; Mohanty, S | 1 |
| Baryza, JL; Booth, JW; He, L; Mero, P; Pham, T; Shaha, SP; Shi, Y; Spaner, DE; Tomic, J; Wender, PA; White, D | 1 |
32 other study(ies) available for phorbol 12,13-dibutyrate and bryostatin 1
| Article | Year |
|---|---|
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxyl Radical; Lyngbya Toxins; Neoplasms; Protein Kinase C | 2010 |
Effect of bryostatin 1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM).
Topics: Antigens, CD; Antigens, CD34; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bryostatins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Lactones; Macrolides; Macrophages; Phorbol 12,13-Dibutyrate; Protein Kinase C; Radiation-Protective Agents; Recombinant Proteins; Signal Transduction; Time Factors | 1992 |
Bryostatin 1 modulates the proliferation and lineage commitment of human myeloid progenitor cells exposed to recombinant interleukin-3 and recombinant granulocyte-macrophage colony-stimulating factor.
Topics: Bryostatins; Cell Differentiation; Cell Division; Diterpenes; Enzyme Activation; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Interleukin-3; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Recombinant Proteins; Terpenes | 1992 |
Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1.
Topics: Antineoplastic Agents; Biological Transport; Bryostatins; Cell Division; Cell Line; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Head and Neck Neoplasms; HeLa Cells; Humans; Isoenzymes; Kinetics; Lactones; Macrolides; Organoplatinum Compounds; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Binding of [3H]bryostatin 4 to protein kinase C.
Topics: Animals; Binding, Competitive; Brain; Bryostatins; Cell Line; Enzyme Activation; Kinetics; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Protein Kinase C; Rats | 1992 |
Corticosteroids inhibit the delivery of short-term activational pulses of phorbol ester and calcium ionophore to human peripheral T cells.
Topics: Adrenal Cortex Hormones; Bryostatins; Calcium; Cell Division; Dexamethasone; Drug Interactions; Enzyme Activation; Humans; Interleukin-2; Ionomycin; Lactones; Lymphocyte Activation; Macrolides; Mifepristone; Monocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Second Messenger Systems; T-Lymphocytes; Time Factors | 1992 |
Response of Jurkat T cells to phorbol ester and bryostatin. Development of sublines with distinct functional responses and changes in protein kinase C activity.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bryostatins; CD3 Complex; Clone Cells; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Humans; In Vitro Techniques; Lactones; Lymphocyte Activation; Macrolides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Count; Cytarabine; Diterpenes; DNA, Neoplasm; Humans; Kinetics; Lactones; Leukemia, Experimental; Leukemia, Myeloid; Macrolides; Phorbol 12,13-Dibutyrate; Phosphorylation; Terpenes; Time Factors; Tumor Cells, Cultured | 1991 |
Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte-macrophage progenitors to recombinant GM-CSF.
Topics: Bryostatins; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lactones; Macrolides; Macrophages; Mitogens; Phorbol 12,13-Dibutyrate; Protein Kinase C; Recombinant Proteins | 1991 |
Effect of the protein kinase C activating agent bryostatin 1 on the clonogenic response of leukemic blast progenitors to recombinant granulocyte-macrophage colony-stimulating factor.
Topics: Antigens; Bryostatins; Cell Division; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Neoplastic Stem Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Recombinant Proteins; Tumor Cells, Cultured | 1991 |
Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Topics: Antineoplastic Agents; Bryostatins; DNA, Neoplasm; Down-Regulation; Enzyme Induction; Humans; Lactones; Macrolides; Neuroblastoma; Norepinephrine; Oncogenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Muscarinic; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Bryostatins; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Activation; Epidermal Growth Factor; Epidermis; Lactones; Macrolides; Mice; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1987 |
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
Topics: Bryostatins; Cell Line; Enzyme Activation; Humans; Lactones; Lamin Type B; Lamins; Leukemia, Myeloid, Acute; Macrolides; Nuclear Envelope; Nuclear Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Protein Kinase C | 1988 |
Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.
Topics: Amino Acids; Bryostatins; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Protein Kinase C; Proteins; Tumor Cells, Cultured | 1988 |
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.
Topics: Animals; Bryostatins; Calcium; Cell Communication; Cells, Cultured; Dose-Response Relationship, Drug; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Skin; Time Factors | 1988 |
Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
Topics: Animals; Binding Sites; Binding, Competitive; Bryostatins; Cell Line; Diglycerides; Enzyme Activation; Eukaryota; Glycerides; Kinetics; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Bryostatins; Carcinogens; Cell Differentiation; Cell Line; Humans; Kinetics; Lactones; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Macrolides; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters | 1987 |
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.
Topics: Animals; Bryostatins; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cells, Cultured; Insulin; Lactones; Macrolides; Mice; Mitogens; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bryostatins; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Cysteine; DNA Primers; Helminth Proteins; Lactones; Ligands; Macrolides; Molecular Sequence Data; Naphthalenes; Phorbol 12,13-Dibutyrate; Phospholipids; Polycyclic Compounds; Protein Kinase C; Receptors, Drug; Recombinant Proteins | 1995 |
Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Bryostatins; Cloning, Molecular; Consensus Sequence; Cysteine; Escherichia coli; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Lactones; Macrolides; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phorbol 12,13-Dibutyrate; Point Mutation; Protein Kinase C; Protein Structure, Secondary; Rats; Recombinant Fusion Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Tritium | 1995 |
Mechanism of transferrin receptor down-regulation in K562 cells in response to protein kinase C activation.
Topics: Bryostatins; Cell Compartmentation; Down-Regulation; Endocytosis; Enzyme Activation; Humans; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bryostatins; Cell Cycle Proteins; Cell Line; Cloning, Molecular; DNA Primers; Humans; Isoenzymes; Lactones; Macrolides; Mice; Molecular Sequence Data; Moths; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phorbol 12,13-Dibutyrate; Polymerase Chain Reaction; Protein Binding; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Transfection; Zinc; Zinc Fingers | 1994 |
Toxicity of phorbol esters for human epithelial cells expressing a mutant ras oncogene.
Topics: Antineoplastic Agents; Bryostatins; Cell Division; Cell Line; DNA; Epithelial Cells; Epithelium; Gene Expression Regulation; Genes, ras; Humans; Lactones; Macrolides; Models, Biological; Mutation; Phorbol 12,13-Dibutyrate; Phorbol Esters; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thyroid Gland; Zinc | 1993 |
Biological activity of 26-succinylbryostatin 1.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Blotting, Western; Bryostatins; Cell Line; Cell Membrane; Chloramphenicol O-Acetyltransferase; Enzyme Activation; Glutathione Transferase; Humans; Kinetics; Lactones; Lung Neoplasms; Macrolides; Melanoma, Experimental; Mice; Mice, Inbred C3H; Phorbol 12,13-Dibutyrate; Platelet Aggregation; Protein Kinase C; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1996 |
Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells.
Topics: Antineoplastic Agents; Bleomycin; Bryostatins; Carcinoma; Carcinoma, Small Cell; Cisplatin; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; Female; Head and Neck Neoplasms; Herpes Simplex Virus Protein Vmw65; Humans; Lactones; Lung Neoplasms; Macrolides; Ovarian Neoplasms; Paclitaxel; Phorbol 12,13-Dibutyrate; Protein Kinase C; Signal Transduction; Tumor Cells, Cultured | 1996 |
Bryostatin 1 induces biphasic activation of protein kinase D in intact cells.
Topics: 3T3 Cells; Animals; Bryostatins; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Lactones; Macrolides; Mice; Mitogens; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate | 1997 |
Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Cell Cycle; Cytarabine; Diterpenes; DNA Fragmentation; Drug Synergism; Enzyme Activation; HL-60 Cells; Humans; Kinetics; Lactones; Macrolides; Oligonucleotides, Antisense; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proto-Oncogene Proteins c-myc; Terpenes; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
The involvement of novel protein kinase C isozymes in influencing sensitivity of breast cancer MCF-7 cells to tumor necrosis factor-alpha.
Topics: Antineoplastic Agents; Breast Neoplasms; Bryostatins; Carcinogens; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Lactams; Lactones; Macrolides; Maleimides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Tumor Necrosis Factor; Sensitivity and Specificity; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding Sites; Bryostatins; Down-Regulation; Isoenzymes; Lactones; Ligands; Macrolides; Mice; Mutagenesis, Site-Directed; Phorbol 12,13-Dibutyrate; Protein Conformation; Protein Kinase C; Protein Kinase C-delta; Tritium | 1999 |
Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D.
Topics: Animals; Bryostatins; Cell Line; Humans; Lactones; Ligands; Macrolides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phospholipids; Protein Binding; Protein Kinase C; Spodoptera; Structure-Activity Relationship | 2003 |
Enhancement of cisplatin sensitivity of cisplatin-resistant human cervical carcinoma cells by bryostatin 1.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bryostatins; Caspase 3; Caspases; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Female; HeLa Cells; Humans; Indoles; Lactams; Macrolides; Phorbol 12,13-Dibutyrate; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transfection; Uterine Cervical Neoplasms | 2005 |
Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antineoplastic Agents, Phytogenic; Bryostatins; Cell Survival; Clinical Trials, Phase IV as Topic; Cytotoxicity, Immunologic; Drug Interactions; Enzyme Activators; Female; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Microtubules; Middle Aged; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Signal Transduction; Tubulin Modulators; Tumor Necrosis Factor-alpha; Vincristine | 2009 |