Compounds > phorbol 12,13-dibutyrate
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phorbol 12,13-dibutyrate and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

phorbol 12,13-dibutyrate has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 142 studies

Research

Studies (142)

TimeframeStudies, this research(%)All Research%
pre-199015 (10.56)18.7374
1990's112 (78.87)18.2507
2000's12 (8.45)29.6817
2010's3 (2.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisher, J; Hankins, WD; Isaacs, MA; Spivak, JL1
Angenstein, F; Jork, R; Staak, S1
Obara, K; Usuki, T; Yabu, H1
Kitamura, K; Kuriyama, H; Teramoto, N; Xiong, Z1
Horio, T; Kohno, M; Murakawa, K; Takeda, T; Yasunari, K; Yokokawa, K1
Diehl, H; Folch, H; Guarda, MI; Maldonado, C; Ojeda, F1
Braha, O; Dale, N; Ghirardi, M; Hochner, B; Kandel, ER; Montarolo, PG1
Glembotski, CC; Hidaka, H; Irons, CE; Sei, CA1
Byrne, JH; Critz, SD1
Ikeda, K; Machida, J; Nishi, K; Sakiyama, H; Ueda, S; Yoshida, M1
Alkon, DL; Etcheberrigaray, R; Lederhendler, II; Matzel, LD1
Faraci, FM; Heistad, DD; Murray, MA1
Boyer, JL; Bruck, R; Gautam, A; Nathanson, MH; Ng, OC1
Cragoe, EJ; Gupta, S; Ruderman, NB; Sussman, I1
Davis, PD; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE1
Bryant, SH; Conte Camerino, D; Govoni, S; Tricarico, D1
Suen, CS; Wilk, S2
Blanchard, LM; Larose, L; Morisset, J; Paquette, B1
Bryant, SH; Conte-Camerino, D1
Cowled, PA; Forbes, IJ; Giannakis, C; Zalewski, PD1
Alberola-Ila, J; Lozano, F; Places, L; Vives, J1
Anwyl, R; McGuinness, N; Rowan, M1
Casillas, T; Delicado, EG; Miras-Portugal, MT; Sen, RP1
Arita, H; Hanasaki, K; Kishi, M1
Endou, M; Hattori, Y; Kanno, M; Tohse, N1
Balapure, AK; Brunswick, M; Feuerstein, N; Glazer, RI; June, CH; Mond, JJ; Witherspoon, K1
Banks, P; Monk, PN1
Doré, M; Neilsen, NR; Slauson, DO1
Kato, H; Ozawa, J; Takata, Y1
Chang, JP; de Leeuw, R; Jobin, RM1
Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ3
Auffredou, MT; Chaouchi, N; Galanaud, P; Leca, G; Sharma, S; Taieb, J; Vazquez, A1
Bell, RM; Hannun, YA; Merrill, AH1
De Graan, PN; De Wit, M; Dekker, LV; Gispen, WH; Spierenburg, H; Versteeg, DH1
Harmody, D; Longley, RE1
Clark, AH; Garland, CJ1
Butler, AP; Mar, PK; McDonald, FF; Ramsay, RL1
Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM1
Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C1
Gruenhaupt, D; Peterson, MW1
Hartzell, P; McConkey, DJ; Orrenius, S1
el-Fakahany, EE; Lai, WS; Rogers, TB1
Pfeffer, LM; Reich, NC1
Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S1
Bonser, RW; Garland, LG; Randall, RW; Spacey, GD1
Buckley, NE; Gibson, K; Spiegel, S; Zhang, H1
Fredholm, B; Gullberg, M; Jondal, M; Kvanta, A; Nordstedt, C1
Baglioni, C; Johnson, SE1
Kalberg, CJ; Sumners, C1
Cline, HT; Constantine-Paton, M1
Chambaz, EM; Keramidas, M; Pelosin, JM; Souvignet, C1
Guitart, X; Marsal, J; Solsona, C1
García-Sáinz, JA; Hong, E; Ransanz, V; Torres-Márquez, ME; Villalobos-Molina, R1
Putney, JW; Sugiya, H1
Alonso, M; Cárdenas, L; Carrera, AC; de Landázuri, MO; Sánchez-Madrid, F; Tugores, A1
Boscá, L; Díaz-Guerra, MJ; Mojena, M1
Hartzell, P; Jondal, M; McConkey, DJ; Orrenius, S1
Auguet, M; Braquet, P; Chabrier, PE; Delaflotte, S1
Badwey, JA; Horn, W; Karnovsky, MJ; Karnovsky, ML; Robinson, JM; Soberman, RJ1
Dandona, P; Morrell, DJ; Preece, MA; Taylor, AM1
Adams, DJ; Sage, SO; van Breemen, C1
el-Fakahany, EE; Lai, WS1
Dandona, P; Jeremy, JY1
Isono, K; Magae, J; Osada, H; Watanabe, C1
Hogans, BB; Spivak, JL1
Kobayashi, H; Mochida, S1
Baudry, M; Lynch, G; Muller, D; Turnbull, J1
May, WS; Tyler, G1
Carter, DA1
Ihara, M; Miasiro, N; Paiva, AC; Yano, M1
de Prost, D; Hakim, J; Khechai, F; Ollivier, V; Ramani, M; Ternisien, C; Vu, T1
Glembotski, CC; McDonough, PM; Stella, SL1
Benishin, CG; Ren, J1
Clegg, JM; McKenna, TM; Williams, TJ1
Nishio, I; Sasajima, H; Shima, H; Toyoda, Y1
Kopp, UC; Smith, LA1
Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y1
Domańska-Janik, K; Zabøocka, B1
Clegg, RA; Johnson, MS; Mitchell, R; Simpson, J2
Black, JL; Yang, KX1
Terrian, DM; Ways, DK1
Fujimoto, M; Furusho, K; Kimata, H; Lindley, I1
Chopra, LC; Twort, CH; Ward, JP1
Arleth, AJ; Nambi, P; Sung, CP1
Boyer, JL; Bruck, R; Nathanson, MH; Roelofsen, H1
Satoh, H1
Busija, D; Nam, M; Thore, CR1
Skoglund, G1
Cupello, A; Hydén, H; Rapallino, MV1
Chaki, S; Muramatsu, M; Otomo, S1
Blobe, GC; Hannun, YA; Khan, WA; Richards, AL1
Black, SC; Chi, L; Fagbemi, SO; Friedrichs, GS; Lucchesi, BR1
Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB1
Mitchell, R; Thomson, FJ1
Johnson, MS; Mitchell, R; Simpson, J1
Endoh, M; Kasai, H; Norota, I; Takanashi, M1
Colucci, WS; Izzo, NJ; Tulenko, TN1
Clegg, RA; Connor, K; Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R1
Krieger, C; Lanius, RA; Shaw, CA; Wagey, R1
Azuma, Y; Kizaki, H; Mizuno, Y; Onishi, Y; Sato, Y; Tadakuma, T1
Delamere, NA; Mito, T1
Kim, KT; Lin, LF; Westhead, EW1
Nakano, R; Shimamoto, T; Yamoto, M1
Cantabrana, B; Fernandez, AI; Hidalgo, A1
Braha, O; Edmonds, B; Kandel, ER; Klein, M; Sacktor, T1
Kitamura, Y; Miyazaki, A; Nomura, Y1
Ebina, S; Nakahata, N; Nakanishi, H; Yamamoto, K1
Benz, D; Möller, K; Perrin, D; Söling, HD1
Moreland, RS; Rokolya, A; Walsh, MP1
Aumailley, M; Gimond, C; Mercier, I; Weber, I1
Hori, M; Ikuhara, T; Isogai, Y; Matsuzaki, K; Nakamura, I; Suda, T; Suzuki, H; Takahashi, N1
Keiser, HR; Oriji, GK2
Fu, WM; Lee, KF; Tang, YB1
Imanaga, I; Inoue, M; Sakamoto, Y; Yano, A1
Hano, T; Kimura, K; Nishio, I; Sasajima, H; Shima, H; Toyoda, Y; Yoshikawa, A1
Almazan, G; Larocca, JN1
Grillner, S; Parker, D; Svensson, E1
Coleman, R; Roma, MG; Shaw, R; Stone, V1
Ciereszko, RE; Guan, Z; Ottobre, AC; Ottobre, JS; Petroff, BK; Stokes, BT1
Alroy, G; Su, H; Yaari, Y1
Dietz, R; Haller, H; Li, PF; Maasch, C; von Harsdorf, R1
Chong, YH; Lee, MJ2
Oleskevich, S; Walmsley, B1
Antunes-Rodrigues, J; Martins, MC; Udrisar, DP; Wanderley, MI1
Eto, W; Hirano, K; Hirano, M; Kanaide, H; Nishimura, J1
Oriji, GK1
Furuya, K; Hiraoka, H; Ikenoya, M; Ikuhara, T; Nagumo, H; Sakurada, K; Sasaki, Y1
Fujishima, M; Hirano, K; Ibayashi, S; Kanaide, H; Nakamura, K; Nishimura, J1
Hidaka, H; Hosoya, T; Ikenoya, M; Sasaki, Y; Suzuki, M; Yamamoto, N1
Chung, KH; Gye, MH; Shin, HJ; Yoo, BS1
Eto, Y; Kandabashi, T; Kunihiro, I; Matsumoto, Y; Miyata, K; Morishige, K; Nakayama, K; Obara, K; Shimokawa, H; Takahashi, S; Takeshita, A1
Burnstock, G; Smith, NC1
Baek, I; Chae, SC; Jeon, SB; Jun, JE; Kim, IK; Kim, J; Park, WH; Seok, YM; Song, MJ1
Blanco, CE; Villamor, E; Zoer, B1
Heaps, CL; Parker, JL; Robles, JC; Sturek, M1
Bradley, PD; Hein, TW; Kuo, L; Potts, LB; Xu, W1

Other Studies

142 other study(ies) available for phorbol 12,13-dibutyrate and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
    Experimental hematology, 1992, Volume: 20, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Erythropoiesis; Erythropoietin; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinases; Protein Tyrosine Phosphatases; Signal Transduction; Staurosporine; Vanadates; Zinc

1992
Phorbol ester-induced changes in rat hippocampal glycoprotein fucosylation.
    Neuroscience letters, 1992, Feb-03, Volume: 135, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Fucose; Glycoproteins; Hippocampus; In Vitro Techniques; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Rats; Staurosporine

1992
Calcium and potassium channel regulation by protein phosphorylation in smooth muscle cells of guinea pig taenia coli.
    Advances in experimental medicine and biology, 1992, Volume: 311

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Atropine; Calcium Channels; Carbachol; Colon; Guinea Pigs; In Vitro Techniques; Isoquinolines; Marine Toxins; Membrane Potentials; Models, Biological; Muscle, Smooth; Nifedipine; Oxazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Potassium Channels; Protein Kinase C

1992
Roles of inositol trisphosphate and protein kinase C in the spontaneous outward current modulated by calcium release in rabbit portal vein.
    Pflugers Archiv : European journal of physiology, 1992, Volume: 421, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium Channels; Guanosine; Heparin; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Membrane Potentials; Muscle, Smooth, Vascular; Neomycin; Norepinephrine; Phorbol 12,13-Dibutyrate; Piperazines; Portal Vein; Protein Kinase Inhibitors; Protein Kinases; Rabbits

1992
Phorbol ester and atrial natriuretic peptide receptor response on vascular smooth muscle.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Guanylate Cyclase; Isoquinolines; Muscle, Smooth, Vascular; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate

1992
Role of protein kinase-C in thymocyte apoptosis induced by irradiation.
    International journal of radiation biology, 1992, Volume: 61, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Death; DNA; DNA Damage; In Vitro Techniques; Interphase; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes

1992
Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons.
    Neuron, 1992, Volume: 9, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Dose-Response Relationship, Drug; Electrophysiology; Isoquinolines; Neurons, Afferent; Neuropeptides; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Serotonin; Synapses

1992
Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes.
    The Journal of biological chemistry, 1992, Mar-15, Volume: 267, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Natriuretic Factor; Cells, Cultured; Endothelins; Heart; Heart Atria; Isoquinolines; Kinetics; Myocardium; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides

1992
Modulation of IK,Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia.
    Journal of neurophysiology, 1992, Volume: 68, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Ganglia; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds

1992
Effects of phorbol ester on lower urinary tract smooth muscles in rabbits.
    European journal of pharmacology, 1992, Nov-10, Volume: 222, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder

1992
Classical conditioning and protein kinase C activation regulate the same single potassium channel in Hermissenda crassicornis photoreceptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Aug-01, Volume: 89, Issue:15

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Conditioning, Classical; Enzyme Activation; In Vitro Techniques; Isoquinolines; Membrane Potentials; Phorbol 12,13-Dibutyrate; Photoreceptor Cells; Piperazines; Potassium Channels; Protein Kinase C; Snails; Tetradecanoylphorbol Acetate

1992
Role of protein kinase C in constrictor responses of the rat basilar artery in vivo.
    The Journal of physiology, 1992, Volume: 445

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Ergolines; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Sphingosine; Vasoconstriction

1992
Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets.
    The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Fluorescent Dyes; Indoles; Intercellular Junctions; Isoquinolines; Kinetics; Liver; Male; Models, Biological; Nickel; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Time Factors; Vasopressins

1992
Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta.
    The American journal of physiology, 1991, Volume: 261, Issue:1 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Bumetanide; Carrier Proteins; Endothelins; Isoquinolines; Male; Membrane Proteins; Ouabain; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rubidium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine

1991
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.
    Agents and actions, 1991, Volume: 32, Issue:3-4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; CD4 Antigens; Cyclic AMP; Down-Regulation; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate

1991
Modulation of rat skeletal muscle chloride channels by activators and inhibitors of protein kinase C.
    Pflugers Archiv : European journal of physiology, 1991, Volume: 418, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Chloride Channels; Chlorides; Isoquinolines; Male; Membrane Proteins; Muscles; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetrahydropapaveroline

1991
Inhibition of pyroglutamyl peptidase II synthesis by phorbol ester in the Y-79 retinoblastoma cell.
    Endocrinology, 1991, Volume: 128, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Humans; Immunoblotting; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1991
Carbamylcholine and phorbol esters desensitize muscarinic receptors by different mechanisms in rat pancreatic acini.
    Pancreas, 1990, Volume: 5, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Calcimycin; Carbachol; Dose-Response Relationship, Drug; Down-Regulation; Gallic Acid; Isoquinolines; Male; Pancreas; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Secretory Rate; Tetradecanoylphorbol Acetate

1990
Chloride channel regulation in the skeletal muscle of normal and myotonic goats.
    Pflugers Archiv : European journal of physiology, 1991, Volume: 417, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Membrane Permeability; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Electric Conductivity; Female; Goats; Ion Channels; Isoquinolines; Male; Membrane Potentials; Muscles; Myotonia; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; Tetrahydropapaveroline

1991
Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester.
    Experimental cell research, 1992, Volume: 198, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aurintricarboxylic Acid; Cell Death; Colchicine; DNA Damage; Electrophoresis, Agar Gel; Etoposide; Humans; Isoquinolines; Leukemia, Lymphocytic, Chronic, B-Cell; Methylprednisolone; Phorbol 12,13-Dibutyrate; Piperazines; Tumor Cells, Cultured

1992
Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
    European journal of biochemistry, 1992, Jan-15, Volume: 203, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Concanavalin A; Cross-Linking Reagents; Diterpenes; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Isoquinolines; Kinetics; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Phytohemagglutinins; Piperazines; Precipitin Tests; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate

1992
Inhibition of an N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice.
    Brain research, 1991, Oct-25, Volume: 562, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; N-Methylaspartate; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase Inhibitors; Rats; Sphingosine; Time Factors

1991
Control of nucleoside transport in neural cells. Effect of protein kinase C activation.
    Advances in experimental medicine and biology, 1991, Volume: 309A

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adrenal Medulla; Animals; Biological Transport; Calcimycin; Caprylates; Cells, Cultured; Diglycerides; Dinucleoside Phosphates; Enzyme Activation; Ethers, Cyclic; Isoquinolines; Kinetics; Okadaic Acid; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Triglycerides

1991
Phorbol ester-induced expression of the common, low-affinity binding site for primary prostanoids in vascular smooth muscle cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Isoquinolines; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Structure-Activity Relationship; Tetradecanoylphorbol Acetate

1991
Protein kinase C is not involved in alpha 1-adrenoceptor-mediated positive inotropic effect.
    The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electric Conductivity; Hydrolysis; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate

1991
Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C.
    The Journal of biological chemistry, 1991, Mar-05, Volume: 266, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Calcium; Enzyme Activation; Isoquinolines; Lymphocyte Activation; Mice; Mice, Inbred DBA; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperazines; Protein Kinase C; Staurosporine; Time Factors

1991
The role of protein kinase C activation and inositol phosphate production in the regulation of cell-surface expression of Mac-1 by complement fragment C5a.
    Biochimica et biophysica acta, 1991, Apr-17, Volume: 1092, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Complement C5a; Cytoplasm; Enzyme Activation; Humans; Inositol Phosphates; Isoquinolines; Kinetics; Macrophage-1 Antigen; Oxygen; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1991
Decreased respiratory burst activity in neonatal bovine neutrophils stimulated by protein kinase C agonists.
    American journal of veterinary research, 1991, Volume: 52, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Female; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate

1991
A selective effect of protein kinase C activators on noradrenaline release compared with subsequent contraction in canine isolated saphenous veins.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diterpenes; Dogs; Electric Stimulation; Enzyme Activation; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polymyxin B; Protein Kinase C; Saphenous Vein; Terpenes

1991
Possible involvement of protein kinase C in gonadotropin and growth hormone release from dispersed goldfish pituitary cells.
    General and comparative endocrinology, 1991, Volume: 81, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Diglycerides; Egtazic Acid; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Growth Hormone; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Pituitary Gland; Protein Kinase C; Tetradecanoylphorbol Acetate; Verapamil

1991
Protein kinase C-dependent and -independent actions of arachidonic acid in GH3 cells.
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cytosol; Enzyme Activation; Isoquinolines; Kinetics; Masoprocol; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Neoplasms; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats

1991
Differential inhibition of interleukin 2- and interleukin 4-mediated human B cell proliferation by ionomycin: a possible regulatory role for apoptosis.
    European journal of immunology, 1991, Volume: 21, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; B-Lymphocytes; Calcium; Cell Death; DNA Damage; Humans; In Vitro Techniques; Interleukin-2; Interleukin-4; Interleukin-6; Ionomycin; Isoquinolines; Lymphocyte Activation; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C

1991
Use of sphingosine as inhibitor of protein kinase C.
    Methods in enzymology, 1991, Volume: 201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine

1991
Evidence for a relationship between B-50 (GAP-43) and [3H]noradrenaline release in rat brain synaptosomes.
    European journal of pharmacology, 1990, Mar-13, Volume: 188, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Chemistry; Calmodulin; GAP-43 Protein; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Neurotransmitter Agents; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphorus Radioisotopes; Piperazines; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Synaptosomes; Veratridine

1990
Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester.
    Endocrinology, 1990, Volume: 127, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Epinephrine; Eye Neoplasms; Humans; Immune Sera; Immunoblotting; Isoquinolines; Kinetics; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Sphingosine; Tetradecanoylphorbol Acetate

1990
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
    The Journal of antibiotics, 1991, Volume: 44, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carcinogens; Cell Adhesion; Colorimetry; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Isoquinolines; Lactams; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Reproducibility of Results; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured

1991
5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction.
    British journal of pharmacology, 1991, Volume: 102, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Female; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rabbits; Serotonin

1991
Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells.
    Experimental cell research, 1991, Volume: 194, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Isoquinolines; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Palmitoylcarnitine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Type C Phospholipases

1991
Protein kinase C and vascular smooth muscle contractility: effects of inhibitors and down-regulation.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Depression, Chemical; Dogs; Down-Regulation; Female; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Staurosporine; Vasoconstriction

1991
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
    FEBS letters, 1991, Jul-08, Volume: 285, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection

1991
A23187 increases permeability of MDCK monolayers independent of phospholipase activation.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cell Line; Cell Membrane Permeability; Choline; Dexamethasone; Dogs; Enzyme Activation; Epithelium; Inositol; Isoquinolines; Kidney; Kinetics; Lipolysis; Mannitol; Phorbol 12,13-Dibutyrate; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Quinacrine

1990
Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis.
    Archives of biochemistry and biophysics, 1990, Volume: 278, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Nucleus; Cells, Cultured; Concanavalin A; Cycloheximide; Dactinomycin; Endonucleases; Interleukin-1; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protease Inhibitors; Protein Biosynthesis; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Thymus Gland

1990
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
    The Biochemical journal, 1990, Apr-01, Volume: 267, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regulation; Isoquinolines; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1990
Evidence for involvement of protein kinase C in the cellular response to interferon alpha.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:22

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; DNA-Binding Proteins; Gene Expression; HeLa Cells; In Vitro Techniques; Interferon Type I; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Staurosporine; Transcription, Genetic; Vesicular stomatitis Indiana virus; Virus Replication

1990
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
    The Journal of biological chemistry, 1990, May-15, Volume: 265, Issue:14

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha

1990
Selectivity of protein kinase inhibitors in human intact platelets.
    Cellular signalling, 1990, Volume: 2, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Carrier Proteins; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Tamoxifen

1990
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
    The Journal of biological chemistry, 1990, Jan-05, Volume: 265, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; DNA; Down-Regulation; Drug Synergism; Fibroblasts; Growth Substances; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1990
Evidence that protein kinase C activation is essential for killing by IL-2-activated lymphocytes.
    Scandinavian journal of immunology, 1990, Volume: 31, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Chromium Radioisotopes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Interleukin-2; Isoquinolines; Killer Cells, Lymphokine-Activated; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1990
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
    The Journal of biological chemistry, 1990, Apr-25, Volume: 265, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoquinolines; Kinetics; Melanoma; Phorbol 12,13-Dibutyrate; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Pregnancy; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1990
Regulation of angiotensin II binding sites in neuronal cultures by protein kinase C.
    The American journal of physiology, 1990, Volume: 258, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain Stem; Cells, Cultured; Homeostasis; Hypothalamus; Isoquinolines; Kinetics; Neurons; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetradecanoylphorbol Acetate

1990
The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system.
    Neuron, 1990, Volume: 4, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Horseradish Peroxidase; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Polyvinyls; Protein Kinase Inhibitors; Rana pipiens; Retina; Retinal Ganglion Cells; Sphingosine; Superior Colliculi; Visual Pathways

1990
Differential inhibition of protein kinase C subtypes.
    Biochemical and biophysical research communications, 1990, Jun-29, Volume: 169, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenal Cortex; Animals; Brain; Gossypol; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Substrate Specificity

1990
Phorbol esters induce neurotransmitter release in cholinergic synaptosomes from Torpedo electric organ.
    Journal of neurochemistry, 1990, Volume: 55, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Botulinum Toxins; Dose-Response Relationship, Drug; Electric Organ; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Synaptosomes; Tetradecanoylphorbol Acetate; Torpedo

1990
Contrasting effects of phorbol dibutyrate and phorbol myristate acetate in rabbit aorta.
    Biochemical and biophysical research communications, 1990, Sep-14, Volume: 171, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cells, Cultured; Epinephrine; In Vitro Techniques; Isoquinolines; Liver; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphates; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate

1990
Protein kinase C-dependent and -independent mechanisms regulating the parotid substance P receptor as revealed by differential effects of protein kinase C inhibitors.
    The Biochemical journal, 1988, Dec-01, Volume: 256, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Indole Alkaloids; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Sugar Phosphates

1988
Activators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteins.
    The Journal of biological chemistry, 1989, Sep-15, Volume: 264, Issue:26

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Calcium Channel Blockers; CD2 Antigens; CD5 Antigens; Cell Membrane; Cells, Cultured; Cycloheximide; Diglycerides; Dinoprostone; Enzyme Activation; Flow Cytometry; Humans; Isoquinolines; Membrane Glycoproteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Immunologic; RNA, Messenger; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate

1989
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes.
    Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Calcium; Fatty Acids; Intracellular Membranes; Isoenzymes; Isoquinolines; Leupeptins; Microsomes, Liver; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phosphatidate Phosphatase; Piperazines; Protein Kinase C; Rats; Spermine

1989
Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.
    The Journal of biological chemistry, 1989, Aug-15, Volume: 264, Issue:23

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; DNA; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thymus Gland

1989
Comparative effects of endothelin and phorbol 12-13 dibutyrate in rat aorta.
    Life sciences, 1989, Volume: 45, Issue:21

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endothelins; Endothelium, Vascular; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Phenylephrine; Phloretin; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction

1989
Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.
    The Journal of biological chemistry, 1988, Feb-25, Volume: 263, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cations, Divalent; Drug Synergism; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine; Sulfonamides; Superoxides

1988
Insulin like growth factor-I, protein kinase-C, calcium and cyclic AMP: partners in the regulation of chondrocyte mitogenesis and metabolism.
    FEBS letters, 1988, Aug-15, Volume: 236, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcium; Cartilage, Articular; Cells, Cultured; Cyclic AMP; Insulin-Like Growth Factor I; Isoquinolines; Mitosis; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Somatomedins; Swine; Verapamil

1988
Synchronized oscillations in cytoplasmic free calcium concentration in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers.
    The Journal of biological chemistry, 1989, Jan-05, Volume: 264, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Benzofurans; Bradykinin; Calcium; Cattle; Cells, Cultured; Cytoplasm; Endothelium, Vascular; Fura-2; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Pulmonary Artery

1989
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate

1987
The role of the diacylglycerol-protein kinase C system in mediating adrenoceptor-prostacyclin synthesis coupling in the rat aorta.
    European journal of pharmacology, 1987, Apr-29, Volume: 136, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcimycin; Calcium; Calcium Channel Blockers; Diglycerides; Epinephrine; Epoprostenol; Glycerides; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic

1987
Rapid screening method for inhibitors of protein kinase C.
    The Journal of antibiotics, 1988, Volume: 41, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomycetales; Alkaloids; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Isoflavones; Isoquinolines; Leukemia, Myeloid; Lyngbya Toxins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

1988
Tumor-promoting phorbol esters stimulate the proliferation of interleukin-3 dependent cells.
    Journal of cellular physiology, 1988, Volume: 137, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cell Division; Cell Survival; Colony-Stimulating Factors; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Interleukin-3; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate

1988
Protein kinase C activators mimic the M2-muscarinic receptor-mediated effects on the action potential in isolated sympathetic neurons of rabbits.
    Neuroscience letters, 1988, Mar-31, Volume: 86, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adrenergic Fibers; Animals; Calcium; Diglycerides; Glycerides; In Vitro Techniques; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rabbits; Receptors, Muscarinic; Tetrodotoxin

1988
Phorbol ester-induced synaptic facilitation is different than long-term potentiation.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:18

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Evoked Potentials; Hippocampus; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Synapses

1988
Phosphorylation of the surface transferrin receptor stimulates receptor internalization in HL60 leukemic cells.
    The Journal of biological chemistry, 1987, Dec-05, Volume: 262, Issue:34

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Exocytosis; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Mathematics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Transferrin

1987
Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components.
    European journal of pharmacology, 1993, Sep-15, Volume: 247, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Gene Expression Regulation; Isoquinolines; Male; Norepinephrine; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; RNA, Messenger; Sulfonamides

1993
Two receptor subtypes are involved in the contractile component of the guinea pig ileum responses to endothelins.
    Journal of cardiovascular pharmacology, 1993, Volume: 22 Suppl 8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Endothelin

1993
Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation.
    Thrombosis and haemostasis, 1993, Nov-15, Volume: 70, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Endotoxins; Enzyme Activation; Gene Expression Regulation; Humans; Isoquinolines; Monocytes; Naphthalenes; Naphthol AS D Esterase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin

1993
Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin.
    The Journal of biological chemistry, 1994, Apr-01, Volume: 269, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Analysis of Variance; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzophenanthridines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoplasm; Endothelins; Fluorescent Dyes; Heart; Heart Atria; Indoles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence

1994
Evidence that prostaglandin E2 can block calcium-activated 86Rb efflux from rat brain synaptosomes via a protein kinase C-dependent mechanism.
    Journal of neurochemistry, 1994, Volume: 62, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Calcium Channel Blockers; Charybdotoxin; Cyclic AMP; Dinoprostone; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Prosencephalon; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rubidium; Scorpion Venoms; Staurosporine; Sulfonamides; Synaptosomes; Thionucleotides

1994
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
    Shock (Augusta, Ga.), 1994, Volume: 2, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides

1994
Role of protein kinase C in relationship between Ca2+ and contractile elements in rat alpha-toxin-permeabilized mesenteric artery.
    Japanese circulation journal, 1995, Volume: 59, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bacterial Toxins; Calcium; Cell Membrane Permeability; Enzyme Activation; Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Staurosporine

1995
A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors.
    The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Enzyme Activation; Isoquinolines; Kidney Pelvis; Male; Naphthalenes; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Staurosporine

1995
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
    The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction

1993
The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.
    Molecular and cellular endocrinology, 1993, Volume: 95, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channels; Dihydropyridines; Female; Growth Hormone; Ion Channel Gating; Isoquinolines; Luteinizing Hormone; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine

1993
PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro.
    Neuroreport, 1994, Dec-30, Volume: 6, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aspartic Acid; Brain Ischemia; Diterpenes; Enzyme Activation; Ginkgolides; Hippocampus; In Vitro Techniques; Isoquinolines; Lactones; Phorbol 12,13-Dibutyrate; Piperazines; Platelet Activating Factor; Potassium; Protein Kinase C; Rats; Rats, Wistar; Tritium

1994
The properties of protein kinase C zeta purified from alpha T3-1 cells using hydroxyapatite chromatography.
    Biochemical Society transactions, 1995, Volume: 23, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Line; Chromatography; Chromatography, DEAE-Cellulose; Durapatite; Indoles; Isoenzymes; Isoquinolines; Kinetics; Maleimides; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats

1995
The involvement of protein kinase C in the contraction of human airway smooth muscle.
    European journal of pharmacology, 1995, Mar-14, Volume: 275, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine

1995
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
    Journal of neurochemistry, 1995, Volume: 64, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine

1995
Interleukin 8 (IL-8) inhibits the interleukin 4 (IL-4)-induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C.
    Biochemical and biophysical research communications, 1995, Feb-27, Volume: 207, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; B-Lymphocytes; Cell Division; Cell Line, Transformed; DNA; Humans; Interleukin-4; Interleukin-8; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger

1995
Differences in sensitivity to the specific protein kinase C inhibitor Ro31-8220 between small and large bronchioles of the rat.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bronchi; Bronchoconstriction; Carbachol; In Vitro Techniques; Indoles; Isoquinolines; Male; Maleimides; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Serotonin

1994
Evidence for involvement of protein kinase C in expression of intracellular adhesion molecule-1 (ICAM-1) by human vascular endothelial cells.
    Pharmacology, 1994, Volume: 48, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Endothelium, Vascular; Humans; Indoles; Intercellular Adhesion Molecule-1; Isoquinolines; Lactams; Lipopolysaccharides; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha; Up-Regulation

1994
Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver.
    Hepatology (Baltimore, Md.), 1994, Volume: 20, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bile; Calcimycin; Calcium; Cytosol; Exocytosis; Horseradish Peroxidase; Hydroquinones; In Vitro Techniques; Isoquinolines; Liver; Male; Perfusion; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Vasopressins

1994
Elevation of intracellular Ca2+ concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells.
    General pharmacology, 1994, Volume: 25, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Fura-2; In Vitro Techniques; Isoproterenol; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rabbits; Sinoatrial Node; Stimulation, Chemical; Tetradecanoylphorbol Acetate

1994
Phorbol ester-induced prostaglandin production in piglet cortical astroglia.
    The American journal of physiology, 1994, Volume: 267, Issue:1 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cerebral Cortex; Dinoprost; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Prostaglandin Antagonists; Prostaglandins; Protein Kinase Inhibitors; Swine

1994
Selective inhibition by H7 and staurosporin of phorbol ester responses in U-937 cells.
    Cellular signalling, 1993, Volume: 5, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Antigens, CD; Calcium; CD18 Antigens; Cell Adhesion; Drug Antagonism; Enzyme Activation; Humans; Isoquinolines; Macrophage-1 Antigen; Molecular Sequence Data; Monocytes; Neoplasm Proteins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Signal Transduction; SRS-A; Staurosporine; Tumor Cells, Cultured

1993
The increase in Cl- permeation across the Deiters' neuron membrane by GABA on its cytoplasmic side is abolished by protein kinase C (PKC) activators.
    Cellular and molecular neurobiology, 1993, Volume: 13, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Membrane; Cell Membrane Permeability; Chlorides; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Neurons; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptors, GABA-A; Vestibular Nucleus, Lateral

1993
Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
    Neurochemistry international, 1994, Volume: 24, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Alkaloids; Animals; Enzyme Activation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Pyridazines; Rats; Rats, Wistar; Serotonin; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate

1994
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
    The Journal of biological chemistry, 1994, Apr-01, Volume: 269, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Platelets; Blotting, Western; Calcium; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Diglycerides; Durapatite; Enzyme Activation; Humans; Isoquinolines; Kinetics; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phospholipids; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sphingosine; Substrate Specificity

1994
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
    Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidines; Isoquinolines; Perfusion; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pinacidil; Piperazines; Protein Kinase C; Rabbits; Staurosporine; Ventricular Fibrillation

1993
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
    Molecular and cellular endocrinology, 1993, Volume: 94, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium

1993
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
    Molecular and cellular endocrinology, 1993, Volume: 95, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine

1993
H7-resistant protein kinase C substrates in two-dimensional gels of proestrous rat anterior pituitary gland.
    Biochimica et biophysica acta, 1993, Dec-16, Volume: 1220, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electrophoresis, Gel, Two-Dimensional; Estrus; Female; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substrate Specificity

1993
Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; Heart Ventricles; Hydrolysis; Indoles; Isoquinolines; Male; Myocardial Contraction; Myocardium; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Prazosin; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha; Staurosporine

1993
Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells.
    The Journal of biological chemistry, 1994, Jan-21, Volume: 269, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Bradykinin; Cells, Cultured; Diglycerides; Down-Regulation; Ethers, Cyclic; Inositol Phosphates; Isoquinolines; Kinetics; Models, Biological; Muscle, Smooth, Vascular; Norepinephrine; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha-1; RNA, Messenger; Tetradecanoylphorbol Acetate

1994
Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.
    FEBS letters, 1993, Aug-23, Volume: 329, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Indoles; Isoquinolines; Lung; Male; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes

1993
Activation of PKC reverses apparent NMDA receptor reduction in ALS.
    Neuroreport, 1993, Volume: 4, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amyotrophic Lateral Sclerosis; Autoradiography; Dizocilpine Maleate; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1993
Topoisomerase inhibitors induce apoptosis in thymocytes.
    Biochimica et biophysica acta, 1993, Jan-17, Volume: 1175, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aphidicolin; Apoptosis; Azides; Camptothecin; Cell Survival; DNA; Etoposide; Isoquinolines; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred BALB C; Phorbol 12,13-Dibutyrate; Piperazines; Quinazolines; Quinazolinones; Sodium Azide; Thymus Gland; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Zinc

1993
Alteration of active Na-K transport on protein kinase C activation in cultured ciliary epithelium.
    Investigative ophthalmology & visual science, 1993, Volume: 34, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Biological Transport, Active; Carrier Proteins; Cell Transformation, Viral; Cells, Cultured; Ciliary Body; Enzyme Activation; Humans; Isoquinolines; Ouabain; Phorbol 12,13-Dibutyrate; Pigment Epithelium of Eye; Piperazines; Potassium; Protein Kinase C; Rubidium Radioisotopes; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase

1993
Protein phosphorylation at a postreceptor site can block desensitization and induce potentiation of secretion in chromaffin cells.
    Journal of neurochemistry, 1993, Volume: 60, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Cattle; Chromaffin System; Drug Synergism; Enzyme Activation; Ethers, Cyclic; Isoquinolines; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface

1993
Possible involvement of protein kinase C in gonadotropin-induced ovulation in the rat ovary.
    Endocrinology, 1993, Volume: 133, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cells, Cultured; Female; Gonadotropins, Equine; Granulosa Cells; Isoquinolines; Luteinizing Hormone; Ovary; Ovulation; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator

1993
Effects of phorbol 12,13-dibutyrate and H-7 in extravascular smooth muscle contraction.
    Pharmacology, 1993, Volume: 47, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Female; Isoquinolines; Muscle, Smooth; Oxytocin; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rats; Rats, Wistar; Uterine Contraction

1993
Oestradiol-17 beta modulates the actions of pharmacologically distinct forms of protein kinase C in rat anterior pituitary cells.
    The Journal of endocrinology, 1993, Volume: 136, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cytosol; Diglycerides; Enzyme Activation; Estradiol; Female; Growth Hormone; Ionomycin; Isoenzymes; Isoquinolines; Luteinizing Hormone; Ovariectomy; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar

1993
The contributions of protein kinase A and protein kinase C to the actions of 5-HT on the L-type Ca2+ current of the sensory neurons in Aplysia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calcium; Calcium Channel Blockers; Electrophysiology; Isoquinolines; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Serotonin; Time Factors

1993
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
    Neurochemistry international, 1993, Volume: 22, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc

1993
Separation of H7-resistant protein kinase C isoforms from gonadotroph-derived alpha T3-1 cells.
    Biochemical and biophysical research communications, 1996, Jan-26, Volume: 218, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Isoquinolines; Maleimides; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C

1996
A protein kinase C with divalent cations contributes to thromboxane A2-induced contraction in rabbit vascular smooth muscle.
    Fukushima journal of medical science, 1995, Volume: 41, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Edetic Acid; Female; Isoquinolines; Magnesium; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphatidylcholines; Piperazines; Protein Kinase C; Rabbits; Thromboxane A2; Vasoconstriction

1995
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
    The Biochemical journal, 1996, Feb-15, Volume: 314 ( Pt 1)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amylases; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Immunoblotting; Isoproterenol; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate

1996
Calcium-and phorbol ester-dependent calponin phosphorylation in homogenates of swine carotid artery.
    The American journal of physiology, 1996, Volume: 271, Issue:2 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calponins; Carotid Arteries; Electrophoresis; Enzyme Inhibitors; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine

1996
Adhesion complexes formed by OVCAR-4 cells on laminin 1 differ from those observed on fibronectin.
    Cell adhesion and communication, 1996, Volume: 3, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Cell Adhesion; Enzyme Inhibitors; Female; Fibronectins; Humans; Laminin; Microscopy, Interference; Ovarian Neoplasms; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Signal Transduction; Talin; Tumor Cells, Cultured; Vinculin

1996
Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.
    Endocrinology, 1996, Volume: 137, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Animals, Newborn; Bucladesine; Calcitonin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dentin; Enzyme Activation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred Strains; Osteoblasts; Phorbol 12,13-Dibutyrate; Protein Kinase C; Signal Transduction; Skull; Tetradecanoylphorbol Acetate; Thionucleotides

1996
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin

1997
Turning of nerve growth cones induced by the activation of protein kinase C.
    Neuroreport, 1997, May-27, Volume: 8, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Purinergic Antagonists; Spinal Cord; Tetradecanoylphorbol Acetate; Xenopus

1997
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents

1997
Cyanide suppression of inwardly rectifying K+ channels in guinea pig chromaffin cells involves dephosphorylation.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenal Medulla; Animals; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Kinetics; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Ribonucleotides; Sodium Cyanide; Uridine Triphosphate

1997
Increased Ca2+ sensitivity of contractile elements via protein kinase C in alpha-toxin permeabilized SMA from young spontaneously hypertensive rats.
    Cardiovascular research, 1997, Volume: 36, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Staphylococcus aureus; Type C Phospholipases

1997
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
    Journal of neuroscience research, 1997, Dec-01, Volume: 50, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate

1997
Substance P modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance.
    The European journal of neuroscience, 1997, Volume: 9, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Adenylate Cyclase Toxin; Alkaloids; Animals; Benzophenanthridines; Cadmium Chloride; Electric Stimulation; Enzyme Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lampreys; Male; Neurons; Notochord; Peptides; Pertussis Toxin; Phenanthridines; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Kinase C; Protein Kinases; Spinal Cord; Substance P; Tetraethylammonium; Thionucleotides; Virulence Factors, Bordetella; Wasp Venoms

1997
Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C.
    Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Antioxidants; Bile Canaliculi; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Leupeptins; Liver; Male; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Tight Junctions; Vacuoles; Vasopressins

1998
Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs.
    The Journal of endocrinology, 1998, Volume: 159, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Corpus Luteum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Ionomycin; Ionophores; Lipoproteins, LDL; Luteal Phase; Phorbol 12,13-Dibutyrate; Progesterone; Prolactin; Protein Kinase C; Staurosporine; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Type C Phospholipases

1998
Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons.
    The Journal of physiology, 1999, Jul-01, Volume: 518, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Atropine; Carbachol; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyramidal Cells; Rats; Receptors, Muscarinic; Signal Transduction; Tetraethylammonium; Tetrodotoxin

1999
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells.
    Circulation, 1999, Aug-31, Volume: 100, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth, Vascular; Naphthalenes; Necrosis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reactive Oxygen Species; Staurosporine; Tetradecanoylphorbol Acetate

1999
Effect of HIV-1 gp41 peptides on secretion of beta-amyloid precursor protein in human astroglial cell line, T98G.
    Journal of molecular neuroscience : MN, 1999, Volume: 12, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; AIDS Dementia Complex; Amyloid beta-Protein Precursor; Astrocytes; Carcinogens; Cell Line; Culture Media, Conditioned; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation, Viral; HIV Envelope Protein gp41; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine

1999
Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides.
    Journal of neurovirology, 2000, Volume: 6, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; CD59 Antigens; Cell Line; Complement Inactivator Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV Envelope Protein gp41; Humans; Immunodominant Epitopes; Lipopolysaccharides; Neuroglia; Neurons; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine

2000
Phosphorylation regulates spontaneous and evoked transmitter release at a giant terminal in the rat auditory brainstem.
    The Journal of physiology, 2000, Jul-15, Volume: 526 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Animals; Cochlear Nucleus; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Indoles; Maleimides; Phorbol 12,13-Dibutyrate; Phosphorylation; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Wistar; Synaptic Transmission; Tetradecanoylphorbol Acetate

2000
Propranolol stimulates histone phosphorylation by a putative PK-C in partially purified homogenate of rat testicular interstitial cells. A possible mechanism for increased testosterone secretion by propranolol.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chromatography, Agarose; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Histones; Leydig Cells; Male; Phorbol 12,13-Dibutyrate; Phosphorylation; Propranolol; Protein Kinase C; Rats; Rats, Wistar; Testis; Testosterone; Tritium

2000
Mitogen-induced up-regulation of non-smooth muscle isoform of alpha-tropomyosin in rat aortic smooth muscle cells.
    European journal of pharmacology, 2000, Oct-13, Volume: 406, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cells, Cultured; Gene Expression Regulation; Male; Mitogens; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Isoforms; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tropomyosin; Up-Regulation

2000
Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin.
    Prostaglandins, leukotrienes, and essential fatty acids, 2000, Volume: 63, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Depression, Chemical; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Heart Rate; Indomethacin; Male; Myocardial Contraction; Myocardial Ischemia; Perfusion; Phorbol 12,13-Dibutyrate; Prostaglandin Antagonists; Protein Kinase C; Rats; Vasodilator Agents

2000
Rho-associated kinase phosphorylates MARCKS in human neuronal cells.
    Biochemical and biophysical research communications, 2001, Jan-26, Volume: 280, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Cell Line; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Recombinant Proteins; rho-Associated Kinases; Serine

2001
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calcium; Endothelin-1; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Kinase C; Rabbits; Vasodilator Agents

2001
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.
    Journal of neurochemistry, 2002, Volume: 81, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Calcium-Binding Proteins; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glucosidases; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Substrate Specificity

2002
Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells.
    Toxicology letters, 2002, Sep-05, Volume: 135, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Chlorodiphenyl (54% Chlorine); Diglycerides; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate

2002
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Volume: 23, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Capillary Permeability; Coronary Vasospasm; Coronary Vessels; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Monomeric GTP-Binding Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; rho-Associated Kinases; Swine

2003
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cantharidin; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Histamine; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prazosin; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases; Vas Deferens

2004
A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Azepines; Calcium; Dose-Response Relationship, Drug; Male; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Time Factors; Vasoconstriction; Vasoconstrictor Agents

2009
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010, Volume: 180, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction

2010
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents

2011
Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles.
    Investigative ophthalmology & visual science, 2013, Nov-15, Volume: 54, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Aspartic Acid Endopeptidases; Debridement; Endothelin-1; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme Activation; Female; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Retinal Artery; Sus scrofa; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System; Viper Venoms

2013