phomactin-a and cyclobutanol

phomactin-a has been researched along with cyclobutanol* in 1 studies

Other Studies

1 other study(ies) available for phomactin-a and cyclobutanol

Article	Year
Selective C-C and C-H bond activation/cleavage of pinene derivatives: synthesis of enantiopure cyclohexenone scaffolds and mechanistic insights. Journal of the American Chemical Society, 2015, May-20, Volume: 137, Issue:19 The continued development of transition-metal-mediated C-C bond activation/cleavage methods would provide even more opportunities to implement novel synthetic strategies. We have explored the Rh(I)-catalyzed C-C activation of cyclobutanols resident in hydroxylated derivatives of pinene, which proceed in a complementary manner to the C-C bond cleavage that we have observed with many traditional electrophilic reagents. Mechanistic and computational studies have provided insight into the role of C-H bond activation in the stereochemical outcome of the Rh-catalyzed C-C bond activation process. Using this new approach, functionalized cyclohexenones that form the cores of natural products, including the spiroindicumides and phomactin A, have been accessed. Topics: Catalysis; Cyclobutanes; Cyclohexanones; Heterocyclic Compounds, 4 or More Rings; Lactones; Models, Molecular; Polyketides; Rhodium; Spiro Compounds; Stereoisomerism	2015

Article

Year

Selective C-C and C-H bond activation/cleavage of pinene derivatives: synthesis of enantiopure cyclohexenone scaffolds and mechanistic insights.

Journal of the American Chemical Society, 2015, May-20, Volume: 137, Issue:19

The continued development of transition-metal-mediated C-C bond activation/cleavage methods would provide even more opportunities to implement novel synthetic strategies. We have explored the Rh(I)-catalyzed C-C activation of cyclobutanols resident in hydroxylated derivatives of pinene, which proceed in a complementary manner to the C-C bond cleavage that we have observed with many traditional electrophilic reagents. Mechanistic and computational studies have provided insight into the role of C-H bond activation in the stereochemical outcome of the Rh-catalyzed C-C bond activation process. Using this new approach, functionalized cyclohexenones that form the cores of natural products, including the spiroindicumides and phomactin A, have been accessed.

Topics: Catalysis; Cyclobutanes; Cyclohexanones; Heterocyclic Compounds, 4 or More Rings; Lactones; Models, Molecular; Polyketides; Rhodium; Spiro Compounds; Stereoisomerism

2015