phloroglucinol and hypericum

phloroglucinol has been researched along with hypericum in 401 studies

Research

Studies (401)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (2.49)	18.2507
2000's	178 (44.39)	29.6817
2010's	141 (35.16)	24.3611
2020's	72 (17.96)	2.80

Authors

Authors	Studies
Chatterjee, SS; Erdelmeier, C; Koch, E; Nöldner, M	1
Hafner, U; Müller, WE; Rolli, M; Schäfer, C; Singer, A; Wonnemann, M	1
Bhattacharya, SK; Chakrabarti, A; Chatterjee, SS	1
Dimpfel, W; Mannel, M; Schober, F	1
Biber, A; Chatterjee, SS; Fischer, H; Römer, A	1
Dimpfel, W; Sauer, S; Schellenberg, R	1
Baghai, T; Kieser, M; Laakmann, G; Schüle, C	1
Bhattacharya, SK; Chatterjee, SS; Müller, WE; Singer, A; Wonnemann, M	1
Heilmann, J; Rali, T; Sticher, O; Winkelmann, K; Zerbe, O	2
Chi, JD; Franklin, M	1
Hu, LH; Khoo, CW; Sim, KY; Vittal, JJ	1
Appendino, G; Bombardelli, E; Jakupovic, J; Verotta, L	1
Lüdtke, R; Schempp, CM; Schöpf, E; Simon, JC; Simon-Haarhaus, B; Winghofer, B	1
Collins, JL; Goodwin, B; Jones, SA; Kliewer, SA; Moore, LB; Serabjit-Singh, CJ; Willson, TM; Wisely, GB	1
Obach, RS	1
Müller, WE; Singer, A; Wonnemann, M	2
Biron, CR	1
Chatterjee, S; Fisunov, A; Krishtal, O; Lozovaya, N; Nöldner, M; Tsintsadze, T	1
Agostini, M; Chatterjee, VK; Love, J; Schwabe, JW; Wentworth, JM	1
Poser, W; Vormfelde, SV	1
Chen, ZL; Hu, LH; Shan, MD	1
Vogel, G	1
Agrosi, M; Harrasser, PC; Mischiatti, S; Savio, D	1
Repcák, M; Tekel'ová, D; Tóth, J; Zemková, E	1
Hansen, SH; Jensen, AG; Nielsen, EO	1
Gobbi, M; Mennini, T; Morazzoni, P	1
Borrelli, F; Di Carlo, G; Ernst, E; Izzo, AA	1
Hunt, EJ; Lester, CE; Lester, EA; Tackett, RL	1
Chatterjee, S; Nöldner, M	1
Philippu, A	1
Reichling, J; Saller, R; Weseler, A	1
Mannel, M; Rommelspacher, H; Siemanowitz, B	1
Baghai, T; Ferrera, A; Laakmann, G; Schüle, C	1
Franke, L; Uebelhack, R	1
Müller, WE; Siebert, B; Singer, A; Wonnemann, M	1
Baumeister, A; Dressman, J; Kaunzinger, A; Schubert-Zsilovecz, M; Westerhoff, K; Wilke, A; Wurglics, M	1
Cowen, PJ; Franklin, M	1
De Montis, MG; Gambarana, C; Giachetti, D; Masi, F; Morazzoni, P; Rinaldi, M; Tolu, PL	1
Gobbi, M; Mennini, T; Moia, M; Morizzoni, P; Pirona, L	1
Chatterjee, SS; Germane, S; Klusa, V; Nöldner, M	1
Calapai, G; Caputi, AP; Ciliberto, G; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A	1
Chatterjee, SS; Heinen, M; Langosch, JM; Nöldner, M; Walden, J; Zhou, XY	1
Bergonzi, MC; Bilia, AR; Gallori, S; Guerrini, D; Vincieri, FF	1
Fuzzati, N; Gabetta, B; Strepponi, I; Villa, F	1
de los Reyes, GC; Koda, RT	2
Coutts, RT; Gu, LD; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ	1
Hansen, SH; Jensen, AG	1
Gobbi, M; Mennini, T	2
Attygalle, A; Bezzerides, A; Eisner, M; Eisner, T; Gronquist, M; Meinwald, J	1
Borner, C; Gilb, B; Kaufmann, T; Kersten, A; Kirkin, V; Kiss, J; Schempp, CM; Simon, JC; Simon-Haarhaus, B; Sleeman, JP; Termeer, CC	1
Hohtola, A; Jalonen, J; Tolonen, A; Uusitalo, J	1
Bray, BJ; Brennan, NJ; Menkes, DB; Perry, NB; Rosengren, RJ	1
Ashurmetov, O; Higuti, T; Honda, G; Ito, M; Kodzhimatov, OK; Matsuhisa, M; Shibata, H; Shikishima, Y; Takaishi, Y; Takeda, Y	1
Buchholzer, ML; Chatterjee, SS; Dvorak, C; Klein, J	1
Herskowitz, I	1
Appendino, G; Belloro, E; Bianchi, F; Bombardelli, E; Lovati, M; Sterner, O; Verotta, L	1
Ang, CY; Cui, Y	1
Kovar, KA; Rager, I; Roos, G; Schmidt, PC	1
Bhattacharya, SK; Ghosal, S; Muruganandam, AV	1
Hirshfeld, A; Mazur, Y; Rehavi, M; Roz, N	1
Bonn, GK; Huck, CW; Pirker, R	1
Adam, P; Arigoni, D; Bacher, A; Eisenreich, W	1
Biber, A; Erdelmeier, C; Lang, F	1
Albert, D; Dingermann, T; Müller, WE; Steinhilber, D; Werz, O; Zündorf, I	1
Caccia, S; Cervo, L; Ekalle-Soppo, CB; Guiso, G; Morazzoni, P; Rozio, M	1
Murch, SJ; Rupasinghe, HP; Saxena, PK	1
Dressman, J; Kaunzinger, A; Schubert-Zsilavecz, M; Westerhoff, K; Wurglics, M	1
Müller, WE	1
Verotta, L	1
Schmitt, J	1
Davis-Searles, PR; Kliewer, SA; Lambert, MH; Maglich, JM; Moore, LB; Noble, SM; Redinbo, MR; Watkins, RE; Wisely, GB	1
Hezel, S; Schempp, CM; Simon, JC	1
Heilmann, J; Sticher, O; Winkelmann, K	1
Andrade, PB; Bastos, ML; Dias, A; Ferreira, M; Seabra, RM; Silva, B; Valentão, P	1
Hübner, AT	1
Butterweck, V; Christoffel, V; Nahrstedt, A; Petereit, F; Spengler, B; Winterhoff, H	1
Schmidt, PC	1
Schubert-Zsilavecz, M; Wurglics, M	2
Juranić, N; Karadzić, I; Macura, S; Milosavljević, S; Trifunović, S; Vajs, V; Vugdelija, S	1
Bommer, S; Hostanska, K; Reichling, J; Saller, R; Weber, M	1
Caccia, S; Cantoni, L; Hauri, L; Mangolini, A; Rozio, M	1
Butterweck, V; Herkenham, M; Winterhoff, H	1
Bommer, S; Hostanska, K; Krasniqi, B; Saller, R; Weber, M	1
Aljancić, I; Gojgić, G; Macura, S; Menković, N; Milosavljević, S; Savikin-Fodulović, K; Vajs, V	1
Gibson, DM; Kaufman, PB; Kirakosyan, A; Sirvent, TM	1
Anand, R; Gupta, VK; Handa, G; Khajuria, RK; Puri, SC; Qazi, GN; Suri, OP; Verma, N	1
De Montis, MG; Gambarana, C; Giachetti, D; Grappi, S; Leggio, B; Nanni, G; Tolu, P; Usai, M	1
Butterweck, V; Simbrey, K; Winterhoff, H	1
Gott, M; Grayson, B; Hanna, M; Neill, JC; Smith, AG; Sunter, A; Wright, CW	1
Gibson, DM; Krasnoff, SB; Sirvent, TM	1
Barecki-Roach, M; Johnson, WW; Wang, EJ	1
Haslinger, E; Kaiser, CS; Römpp, H; Schmidt, PC; Seger, C	1
Chatterjee, SS; Koch, E; Schrattenholz, A; Schroer, K	1
Ang, CY; Cai, H; Cui, YY; Frye, R; Hutzler, JM; Komoroski, BJ; Lehmann, T; Strom, SC; Tracy, TS; Venkataramanan, R; Zhang, S	1
Buchholzer, ML; Chatterjee, SS; Hartmann, J; Kiewert, C; Klein, J	1
Athanasas, K; Fokialakis, N; Kletsas, D; Magiatis, P; Pratsinis, H; Skaltsounis, AL	1
Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N	1
Eggenreich, K; Likussar, W; Michelitsch, A; Rückert, U; Wintersteiger, R; Wurglics, M	1
Funicello, M; Gobbi, M; Mennini, T; Moia, M; Morazzoni, P; Riva, A	1
Eckert, GP; Jourdan, C; Karas, M; Keller, JH; Müller, WE; Schubert-Zsilavecz, M; Volmer, DA	1
Burhenne, J; Haefeli, WE; Martin-Facklam, M; Riedel, KD; Rieger, K; Walter-Sack, I	1
Ang, CY; Cui, Y; DiNovi, M; Freeman, JP; Heinze, TM; Hu, L; Kozak, K; Liu, FF; Luo, W; Mattia, A	1
Bauer, S; Budde, K; Frank, B; Johne, A; Mai, I; Perloff, ES; Roots, I; Uehleke, B	1
Dienel, A; Trautmann-Sponsel, RD	1
Zanoli, P	1
Appendino, G; Bombardelli, E; Lovaglio, E; Sterner, O; Verotta, L	1
Ashraf-Khorassani, M; Taylor, LT; Wang, Z	1
Fricker, G; Kressmann, S; Müller, WE; Weber, CC	1
Blumberg, B; Grün, F; Sadatrafiei, A; Sun, A; Tabb, MM; Zhou, C	1
Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R	1
Beerhues, L; Beuerle, T; Boubakir, Z; Liu, B	1
Beerhues, L; Beuerle, T; Boubakir, Z; El-Moghazy, SA; Klingauf, P; Mellenthin, A	1
Burbassi, S; Caccia, S; Canetta, A; Cervo, L; Ekalle-Soppo, CB; Gobbi, M; Guiso, G; Mennini, T; Morazzoni, P; Pirona, L; Riva, A; Rozio, M	1
Ang, CY; Drumm, P; Liu, F; Pan, C	1
Bässler, D; Schulz, HU; Schürer, M; Weiser, D	2
Davidson, JR; Gadde, KM; Greenblatt, DJ; Harlan, W; Krishnan, KR; Parker, CB; Ritz, L; Shader, RI; Vitiello, B	1
Altieri, V; Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Montanaro, V	1
Carenzi, GE; Jeso, V; Nicolaou, KC	1
Albring, DV; Bernardi, AP; Bordignon, SA; Bridi, R; Dutra-Filho, CS; Ferraz, AB; Henriques, AT; Schripsema, J; von Poser, GL	1
Clennett, C; Gibbons, S; Hausmann, S; Moser, E; Smith, E; Stavri, M	1
Martínez-Poveda, B; Medina, MA; Quesada, AR	1
Albring, D; Bernardi, AP; Dall'agnol, R; Ferraz, A; Nör, C; Schapoval, EE; von Poser, GL	1
Cucculelli, M; Massi, M; Mattioli, L; Perfumi, M	1
Egorin, MJ; Komoroski, BJ; Parise, RA; Strom, SC; Venkataramanan, R	1
Krusekopf, S; Roots, I	1
Bauer, S; Drewelow, B; Frank, B; Klammt, S; Kundt, G; Majcher-Peszynska, J; Miekisch, W; Mueller, SC; Mundkowski, RG; Sievers, H; Uehleke, B	1
Lawvere, S; Mahoney, MC	1
Ashton, D; Chandrasekera, DH; Heinrich, M; Middleton, R; Welham, KJ	1
Furumoto, M; Haito, S; Ito, M; Kawai, Y; Miyamoto, K; Terao, J	1
Amores-Sánchez, MI; Martínez-Poveda, B; Medina, MA; Quesada, AR	1
Butterweck, V; Derendorf, H; Drewelow, B; Frank, B; Madabushi, R	1
Klier, CM; Lee, A; Lenz, G; Saria, A; Schäfer, MR; Schmid-Siegel, B; Zernig, G	1
Smelcerovic, A; Spiteller, M; Zuehlke, S	1
Albert, D; Feisst, C; Verotta, L; Werz, O	1
Cerpa, W; Dinamarca, MC; Garrido, J; Hancke, JL; Inestrosa, NC	1
Daneshfar, R; Eckert, GP; Müller, WE; Sleno, L; Volmer, DA	1
Abbruscato, T; Bickel, U; Kiewert, C; Klein, J; Kumar, V; Mdzinarishvili, A; van der Schyf, CJ	1
Beerhues, L	1
Duke, CC; Duke, RK; Hook, JM; Lee, JY; Tran, VH	1
Gibbons, S; Shiu, WK	1
Heber, D; Henry, GE; Jayaprakasam, B; Nair, MG; Raithore, S; Seeram, NP; Zhang, Y	1
Cao, J; Chan, E; Chen, X; Duan, W; Hu, ZP; Huang, M; Wen, JY; Yang, XX; Yu, XQ; Zhou, SF	1
Hohtola, A; Hokkanen, J; Karppinen, K; Mattila, S; Tolonen, A	1
Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S	1
Biggin, S; Caniato, R; Dell'Aica, I; Garbisa, S	1
Jäger, AK; Jørgensen, LB; Soelberg, J	1
Bornancin, A; Della Loggia, R; Morazzoni, P; Pace, R; Riva, A; Sosa, S; Tubaro, A	1
Benkiki, N; Chosson, E; Costentin, J; do Rego, JC; Kabouche, Z; Seguin, E	1
Gödtel-Armbrust, U; Kelber, O; Kroll, U; Metzger, A; Wojnowski, L	1
Klejdus, B; Kuban, V; Pavlík, M; Vacek, J	1
Klejdus, B; Kubán, V; Vacek, J	1
Abrahamyan, A; Beerhues, L; Boubakir, Z; Bringmann, G; Charchoglyan, A; Ebizuka, Y; Fujii, I; Gulder, TA; Kutchan, TM; Vardapetyan, H	1
Essin, K; Gollasch, M; Harteneck, C; Henke, B; Kazanski, V; Leuner, K; Müller, M; Müller, WE	1
Birt, DF; Delate, K; Dixon, PM; Hammer, KD; Hillwig, ML; Murphy, PA; Solco, AK; Wurtele, ES	1
Kraft, K	1
Butterweck, V; Schmidt, M	1
Cargnin, S; Fritz, D; Montanha, JA; Roehe, PM; Schripsema, J; Venturi, CR; von Poser, GL	1
Cirak, C; Radusiene, J	1
Chancellor, MB; Thomas, CA; Tyagi, P; Tyagi, S; Yoshimura, N	1
Gibbons, S; Mu, Q; Shiu, WK; Xiao, ZY; Zeng, YH	1
Beffy, P; D'Aleo, V; Lupi, R; Marchetti, P; Masiello, P; Menegazzi, M; Novelli, M; Suzuki, H; Tedeschi, E; Zoratti, E	1
Canegallo, L; Carrassi, A; Demarosi, F; Lodi, G; Sardella, A; Tarozzi, M	1
Araki, A; Ishiyama, H; Kashiwada, Y; Kobayashi, J; Kubota, T; Mikami, Y; Takaishi, Y; Tanaka, N	1
Birt, DF; Hammer, KD; Hillwig, ML; Wurtele, ES	1
Lin, CN; Wu, CC; Yang, SC; Yen, MH	1
Ferdinandov, D; Girreser, U; Kitanov, G; Momekov, G; Nedialkov, P; Zheleva-Dimitrova, D	1
Bertoli, A; Giovannini, A; Guardo, AD; Mazzetti, M; Pistelli, L; Ruffoni, B; Spinelli, G	1
Hashida, W; Ikeshiro, Y; Kashiwada, Y; Sekiya, M; Takaishi, Y; Tanaka, N	1
Hashida, C; Kashiwada, Y; Ogawa, M; Takaishi, Y; Tanaka, N	1
Cirak, C; Ivanauskas, L; Janulis, V; Radusiene, J	3
Drewelow, B; Frank, B; Klammt, S; Kundt, G; Lehnfeld, R; Majcher-Peszynska, J; Mueller, SC; Mundkowski, RG; Sievers, H; Thurow, K; Uehleke, B	1
Bondesson, U; Hedeland, M; Knutson, L; Lennernäs, H; Lundahl, A	1
Khalifa, AE; Mohamed, MR; Sabry, GM; Sabry, NA; Tadros, MG; Youssef, AM	2
Chen, J; Chen, X; Du, J; Guan, S; He, YW; Huang, M; Li, JL; Su, QB; Wang, XD; Zeng, J; Zhang, JX; Zhou, SF	1
Bowen-Forbes, CS; Campbell, MS; Henry, GE; Li, L; Liu, Y; Nair, MG; Rowley, DC; Seeram, NP; Zelinsky, AA	1
Dodt, G; Feisst, C; Fischer, L; Franke, L; Hoernig, C; Hoffmann, M; Koeberle, A; Pergola, C; Rådmark, O; Rakonjac, M; Rossi, A; Sautebin, L; Schneider, G; Steinhilber, D; Werz, O	1
Kavanagh, DJ; Sarris, J	1
Borsarini, A; Caniato, R; Filippini, R; Piovan, A	1
Kashiwada, Y; Kobayashi, J; Kubota, T; Takaishi, Y; Tanaka, N	1
Anthony, MN; Dinchuk, JE; Dulac, HA; Grace, JE; Kim, S; Mosure, KW; Orcutt, T; Pizzano, J; Sauer, MB; Simmermacher, J; Sinz, M; Vuppugalla, R; Zoeckler, ME	1
Baladão, LF; Cargnin, ST; Cassel, E; de Matos Nunes, J; Haas, JS; Rech, SB; Vargas, RF; von Poser, GL	1
Dinamarca, MC; Griffith, TN; Inestrosa, NC; Varela-Nallar, L	1
Chen, XQ; Cheng, X; He, J; Li, MM; Li, Y; Pan, ZH; Peng, LY; Wang, K; Xu, G; Zhao, QS	1
Moon, HI	1
Ishida, Y; Kuroyanagi, M; Nakane, T; Sekita, S; Shirota, O; Someya, K; Tokita, F	1
Caccia, S; Gobbi, M	1
Elstner, EF; Heilmann, J; Kraus, B; Wolff, H	1
Butterweck, V; Nahrstedt, A	1
Adlington, RM; Baldwin, JE; George, JH; Hesse, MD	1
Gonoi, T; Kashiwada, Y; Kobayashi, J; Otani, M; Shibazaki, A; Shiro, M; Takaishi, Y; Tanaka, N	1
Gilani, AH; Khan, AU	1
Gibbons, S; Mu, Q; Osman, K; Rahman, M; Shinde, K; Wang, W; Zeng, YH	1
Hokkanen, J; Mattila, S; Tolonen, A; Turpeinen, M	1
Bai, G; Cao, X; Ito, Y; Li, Y; Ren, H; Wang, Q; Xu, C	1
González-Sarrías, A; Henry, GE; Lebo, M; Manning, K; Petrunak, E; Seeram, NP	1
Chen, JP; Li, MM; Liu, JY; Liu, Z; Wang, DM; Wang, R; Wang, SX; Wang, YF; Yang, DP	1
Hatano, T; Inoue, R; Ito, H; Ochi, M; Onoue, S; Seto, Y; Yamada, S	1
Gonoi, T; Kobayashi, J; Mamemura, T; Shibazaki, A; Tanaka, N	1
Curry, J; Gibbons, S; Malkinson, JP; Rahman, MM; Shiu, WK; Stapleton, P; Zloh, M	1
Chen, XQ; Cheng, X; He, J; Li, KZ; Li, MM; Li, Y; Pan, ZH; Peng, LY; Wang, K; Xu, G; Zhao, QS	1
Barros, FM; Cassel, E; Nunes, JM; Silva, FC; Vargas, RM; von Poser, GL	1
Abe, S; Kobayashi, J; Tanaka, N	1
Costentin, J; Do Rego, JC; Müller, LG; Nunes, JM; Rates, SM; Stein, AC; Stolz, ED; Viana, AF; von Poser, GL	1
Henry, GE; Janssen, MJ; Laplante, KL; Matta, H; Rowley, DC; Sarkisian, SA	1
Farag, MA; Wessjohann, LA	1
Heilmann, J; Jürgenliemk, G; Schmidt, S; Skaltsa, H	1
Miller, CD; Mortensen, T; Shen, F; Shen, S; Sims, RC; Walsh, MK	1
Casetti, F; Haag, SF; Kleemann, A; Lademann, J; Meinke, MC; Müller, ML; Schanzer, S; Schempp, CM; Wölfle, U	1
Kraus, GA; Liu, F	1
Ji, TF; Ma, J; Su, YL; Wang, AG; Yang, JB	1
Caliskan, O; Camas, N; Cirak, C; Radusiene, J; Stanius, Z	1
Chen, SY; Cheng, YB; Chien, CT; Fazary, AE; Lin, WW; Lin, YC; Lin, YJ; Lo, IW; Ong, SC; Shen, YC	1
Chen, XQ; Gao, X; Li, Y; Peng, LY; Wang, K; Wang, YY; Xu, G; Zhao, QS	1
Amaral, MD; Calfa, G; Harteneck, C; Inoue, T; Leuner, K; Li, W; Pozzo-Miller, L; Rudolph, S; Schuwald, AM	1
Huang, HQ; Jia, M; Jiang, YP; Jin, GL; Man, XH; Mao, ZJ; Qin, LP; Xin, WB; Zhao, XX; Zheng, CJ	1
Heilmann, J; Jürgenliemk, G; Schmidt, S; Schmidt, TJ; Skaltsa, H	1
Cargnin, ST; Cassel, E; Cibulski, S; Montanha, J; Roehe, P; Tasca, T; Vargas, RM; Vieira, Pde B; von Poser, GL	1
Capasso, R; Pessina, F; Valeri, A; Valoti, M	1
Mammino, L	1
Crispin, MC; Hur, M; Kim, YH; Park, T; Wurtele, ES	1
Arndt, S; Haag, SF; Kleemann, A; Lademann, J; Meinke, MC	1
Häberlein, H; Hage-Hülsmann, A; Jakobs, D; Kolb, C; Prenner, L; Weiser, D	1
Abujamra, AL; de Barros, FM; de Farias, CB; Pinhatti, AV; Poser, GL; Schwartsmann, G	1
Brenn, A; Eiden, M; Fischer, A; Groschup, MH; Grube, M; Jedlitschky, G; Keller, M; Strohmeier, B; Vogelgesang, S	1
Bouron, A; Lorrain, E	1
Chimirri, S; Ciriaco, M; De Sarro, G; Esposito, S; Mammì, M; Mazzitello, C; Palleria, C; Patanè, M; Pugliese, M; Russo, E; Scicchitano, F; Upton, R; Whalley, BJ	1
Chen, CQ; Liu, X; Ma, JZ; Wang, H; Wu, CY; Xu, G; Yang, LX; Yang, XW; Zhang, JJ	1
Bombardelli, E; Corbo, F; Franchini, C; Gibbons, S; Marilena, M; Rosato, A; Schiavone, BI; Verotta, L	1
Aizawa, K; Nakamura, K; Tanoue, A; Yamauchi, J	1
Braga, A; Centurião, FB; Kolling, J; Machado, FR; Müller, LG; Poser, Gv; Rates, SM; Tagliari, B; Wyse, AT	1
Beffy, P; De Tata, V; Marchetti, P; Martino, L; Masiello, P; Masini, M; Menegazzi, M; Novelli, M; Pippa, A; Porozov, S; Sgarbossa, A	1
Burico, M; Galeotti, N; Ghelardini, C; Maidecchi, A; Mattoli, L	1
Crockett, S; Feistel, B; Heinze, HJ; Hofrichter, J; Krohn, M; Lange, C; Pahnke, J; Schumacher, T; Sharbel, TF; Walbroel, B	1
Birt, DF; Hammer, KD	1
Çiğ, B; Nazıroğlu, M; Özgül, C	1
Kong, LY; Luo, JG; Pan, K; Zhang, YM; Zhou, ZB	1
Ding, Y; Ferreira, D; Li, XN; Liu, X; Walker, LA; Xu, G; Yang, LX; Yang, XW; Zhang, JJ	1
Liu, RD; Ma, J; Su, YL; Wang, AG; Yang, JB	1
Hasse, DR; Rates, SM; Stolz, ED; von Poser, GL	1
Heilmann, J; König, B; Schmidt, S; Sun, Q; Tremmel, M	1
Bombardelli, E; Corbo, F; Franchini, C; Gibbons, S; Marilena, M; Pia Schiavone, BI; Rosato, A; Verotta, L	1
Liao, Y; Ma, JZ; Xiao, QL; Xu, G; Yang, J; Yang, LX; Yang, XW; Zhang, JJ	1
Chen, SL; Force, R; Fortier, E; Heneks, J; Henry, GE; Rovnyak, D; Rowlands, E	1
Ccana-Ccapatinta, GV; da Costa, PF; Rates, SM; Stolz, ED; von Poser, GL	1
Antonio, CB; da Costa, PF; Müller, LG; Noël, F; Rates, SM; Stolz, ED; von Poser, GL	1
Chen, C; Huang, SX; Li, D; Li, XN; Li, Y; Liu, J; Luo, Z; Sun, B; Xue, Y; Yang, J; Yao, G; Zhang, J; Zhang, Y; Zhu, H	1
Chen, HJ; Chen, JJ; Lin, YL	1
Chen, HF; Dai, Y; Qiu, YQ; Tian, WJ; Yao, XJ; Yao, XS; Zhang, XK	1
Beck, A; Belkacemi, T; Flockerzi, V; Sell, TS	1
Fedoročko, P; Gálová, E; Imreová, P; Kožurková, M; Loderer, D; Miadoková, E; Plšíková, J; Šemeláková, M; Ševčovičová, A	1
Ding, ZJ; Lao, YZ; Li, XN; Liao, Y; Liu, X; Xu, G; Xu, HX; Yang, J; Yang, XW; Zhang, JJ	1
Chen, C; Li, Y; Liu, J; Luo, Z; Sun, B; Wei, G; Xue, Y; Yao, G; Zhang, J; Zhang, Y; Zhu, H	1
Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA	1
Ding, Y; Ferreira, D; Li, MM; Liao, Y; Liu, X; Qin, HB; Xu, G; Yang, XW; Zhang, JJ	1
Kong, LY; Luo, J; Wang, XB; Xu, WJ; Yang, MH; Zhu, MD	1
Bagnati, R; Cantoni, L; Fracasso, C; Gobbi, M; Guiso, G; Morazzoni, P; Passoni, A; Riva, A	1
Bullita, E; Fobofou, SA; Franke, K; La Colla, P; Porzel, A; Sanna, G; Wessjohann, LA	1
Heilmann, J; Kokanova-Nedialkova, ZK; Momekov, G; Nedialkov, PT	1
Chen, C; Chen, X; Liu, J; Luo, Z; Sun, B; Tong, Q; Wang, J; Xue, Y; Yang, J; Yao, G; Zhang, Y; Zhu, H	1
Liao, Y; Liu, X; Ma, JZ; Xu, G; Yang, XW; Zhang, JJ	1
Alves, G; Domingues, F; Duarte, AP; Gallardo, E; Granadeiro, LB; Martinho, A; Moreno, I; Silva, SM; Silvestre, S	1
Aghaee, A; Haghmorad, D; Mahmoudi, M; Nosratabadi, R; Rastin, M; Salehipour, Z; Sankian, M; Tabasi, N; Zamani, S	1
Bardón, A; Borkosky, SA; Giménez, A; Salamanca, E; Socolsky, C	1
Bordignon, SAL; Bridi, H; Ccana-Ccapatinta, GV; Meirelles, GC; Rates, SMK; Stolz, ED; von Poser, GL	1
Čellárová, E; Janfelt, C; Kimáková, K; Kucharíková, A	1
Beerhues, L; Beuerle, T; Gaid, M; Haas, P; Scholl, S	1
Fobofou, SA; Franke, K; Harmon, CR; Lonfouo, AH; Wessjohann, LA; Wright, SM	1
Brandt, W; Fobofou, SA; Franke, K; Porzel, A; Wessjohann, LA	1
Liu, RD; Ren, J; Su, YL; Wang, AG; Wei, Q; Yang, JB	1
Li, YP; Ma, WG; Su, J; Xu, G; Yang, XW	1
Chen, C; Hu, L; Li, XN; Liu, J; Wang, Z; Xue, Y; Zhang, J; Zhang, Y; Zhu, H	1
Kong, LY; Li, ZR; Luo, JG; Wang, XB; Zhou, ZB	1
Gao, W; Gu, ZY; Hou, WZ; Ji, TF; Li, L; Peng, Y; Sun, H; Wang, XL; Xing, JG; Xu, F; Zhao, J	1
Kashiwada, Y; Kobayashi, J; Tanaka, N; Tsuji, E	1
Kashiwada, Y; Lu, S; Tanaka, N; Tatano, Y	1
Gao, W; Gu, ZY; Hu, JW; Ji, TF; Shi, MJ; Wang, JJ; Wei, CJ; Xing, JG; Xu, F; Zhao, J; Zhen, B	1
Beffy, P; De Tata, V; Giacopelli, D; Gregorelli, A; Masiello, P; Menegazzi, M; Novelli, M; Porozov, S	1
Carrubba, A; Lazzara, S; Militello, M; Napoli, E; Saia, S	1
Xu, G; Yang, J; Yang, XW	1
Ho, CY; Ng, QX; Venkatanarayanan, N	1
Beerhues, L; Behrends, S; Biedermann, E; Füller, J; Gaid, M; Haas, P; Krull, R; Müller-Goymann, C; Scholl, S; Wittstock, U	1
Bridi, H; Macedo, AJ; Menezes, CB; Rigo, GV; Tasca, T; Trentin, DDS; von Poser, GL	1
Bruňáková, K; Čellárová, E	1
Chen, C; Guo, Y; Huang, J; Li, XN; Liu, J; Luo, Z; Tong, Q; Xue, Y; Zhang, J; Zhang, N; Zhang, Y; Zhu, H	1
Bordignon, SAL; Bridi, H; Meirelles, GC; Rates, SMK; von Poser, GL	1
Antognoni, F; Bonvicini, F; Cornioli, L; Fiorentino, A; Mandrone, M; Poli, F; Sanna, C; Scognamiglio, M	1
Beerhues, L; Gaid, M; Haas, P; Scholl, S; Zarinwall, A	1
Liu, R; Su, Y; Wang, A; Yang, J	1
Abdollahi, M; Bahramsoltani, R; Rahimi, R; Soleymani, S	1
Cao, X; Guo, Y; Jin, DQ; Lee, D; Liang, Y; Liu, F; Ohizumi, Y; Tuerhong, M; Wang, P; Xu, J; Yang, X	1
Gao, W; Hu, J; Ji, T; Jiang, J; Shi, M; Sun, H; Wang, J; Wei, C; Xu, F; Zhen, B	1
Kong, L; Li, X; Li, Y; Luo, J; Xue, G; Zhou, Z	1
Beffy, P; Gregorelli, A; Mascia, F; Masiello, P; Menegazzi, M; Novelli, M; Porozov, S; Vantaggiato, C	1
Chen, C; Du, G; Gong, X; Guo, J; Li, D; Xue, Y; Zhang, J; Zhang, Y; Zhu, H	1
Chrubasik-Hausmann, S; McLachlan, AJ; Vlachojannis, J	1
Dagnino, APA; de Barros, FMC; Dorneles, GP; Fonseca, SG; Júnior, LCR; Mesquita, CS; Monteiro, MC; Peres, A; Romão, PRT; Teixeira, VON; Vidal Ccana-Ccapatinta, G; von Poser, GL	1
Butterweck, V; Kalbhenn-Aziz, H; Kolb, C; Verjee, S; Weston, A	1
Canducci, F; Caredda, A; Ceresola, ER; Corona, A; Cortis, P; Esposito, F; Fiorentino, A; Graziani, V; Montisci, M; Poli, F; Sanna, C; Scognamiglio, M; Tramontano, E	1
Dresler, S; Kováčik, J; Sowa, I; Strzemski, M; Wójciak-Kosior, M	1
Ilieva, Y; Kokanova-Nedialkova, Z; Momekov, G; Nedialkov, PT	1
Hu, K; Li, YP; Xu, G; Yang, XW	1
Chen, DZ; Gu, W; Hao, XJ; Huang, LJ; Tian, DS; Xiao, CX; Yan, H; Yi, P; Yuan, CM; Zeng, YR	1
Bridi, H; Meirelles, GC; von Poser, GL	1
Bridi, H; Dischkaln Stolz, E; Elingson da Silva Costa, B; Guerini, L; Lino von Poser, G; Maikon Corrêa de Barros, F; Maris Kuze Rates, S	1
Chen, C; Duan, X; Guo, Y; Li, XN; Liu, J; Luo, Z; Sun, W; Xue, Y; Zhang, N; Zhang, Q; Zhang, Y; Zhou, Q; Zhu, H	1
Hu, JW; Ji, TF; Jiang, JD; Li, L; Shi, MJ; Wang, JJ	1
Xu, G; Yang, XW; Ye, Y; Zhou, Y	1
Kong, LY; Li, YR; Lu, WJ; Luo, J; Wei, SS; Xu, WJ	1
An, Z; Chen, X; Gao, JM; Huangfu, Y; Li, CH; Liu, PL; Yan, XT; Zhang, YT	1
Boonen, G; Bussmann, H; Drewe, J; Franken, S; Häberlein, H; Keksel, N; Unger, M	1
Adiwidjaja, J; Boddy, AV; McLachlan, AJ	1
Drewe, J; Hirsch, M; Krähenbühl, S; Kruttschnitt, E; Lissy, M; Nicolussi, S; Uricher, J; Zahner, C	1
Ao, Z; Chen, C; Kong, LY; Liu, YY; Luo, JG; Wang, XB; Xu, QQ; Zhu, DR	1
Ci, R; Hu, JW; Ji, TF; Jiang, JD; Li, L; Shi, MJ; Wang, JJ; Zhen, B	1
Fan, SQ; Xia, F; Xu, G; Yang, XW; Ye, YS; Zhang, XW	1
Cao, Y; Chen, C; Duan, X; Guo, Y; Luo, Z; Wang, J; Xue, Y; Zhang, N; Zhang, Y; Zhu, H	1
Jiang, K; Lu, Q; Meng, LH; Qu, SJ; Tan, CH; Zhang, HB; Zhang, X	1
Dall'Acqua, S; Hošek, J; Pant, DR; Peron, G; Rajbhandary, S	1
Kashiwada, Y; Niwa, K; Tanaka, N; Yano, Y	1
Kashiwada, Y; Niwa, K; Tanaka, N; Tatano, Y; Yagi, H	1
Ilieva, Y; Kokanova-Nedialkova, Z; Momekov, G; Nedialkov, PT; Zheleva-Dimitrova, D	1
Carrubba, A; Lazzara, S; Napoli, E	1
Beckenkamp, A; Bridi, H; Buffon, A; Elingson, B; Maurmann, N; Pranke, P; von Poser, GL	1
Grossman, RB; Yang, XW	1
Gottschaldt, M; Kretzer, C; Schubert, S; Schubert, US; Shkodra-Pula, B; Traeger, A; Voelker, S; Werz, O	1
Du, SZ; Li, WY; Nian, Y; Xu, G; Yang, J; Ye, YS	1
Iatrou, G; Koui, EM; Koulakiotis, NS; Lamari, FN; Papaioannou, C; Papasotiropoulos, V; Tsarbopoulos, A; Zeliou, K	1
Ji, T; Li, J; Shi, M; Sun, H; Suo, X; Wang, J; Wang, X; Zhen, B	1
Gu, W; Hao, X; Hu, Z; Huang, L; Li, Y; Lou, H; Yi, P; Yuan, C; Zeng, Y	1
Ji, TF; Li, JG; Sun, H; Sun, HR; Suo, XY; Wang, JJ; Wang, X; Zhen, B	1
Chen, WT; Chung, JG; Hsu, FT; Wu, CT	1
Fang, QQ; Jiang, K; Liu, YN; Qu, SJ; Tan, CH; Wang, QQ; Wang, XD; Wu, LZ	1
Chen, X; Chen, Y; Du, Y; Ma, Z; Teng, H; Yang, G	1
Kong, LY; Li, QJ; Lu, WJ; Luo, J; Tang, PF; Xu, WJ; Zhou, X	1
Altschmied, L; D'Auria, JC; Ravindran, BM; Rizzo, P; Rutten, T	1
Hikosaka, K; Ishimaru, K; Li, L; Nakayama, H; Norose, K; Shinjyo, N; Suzuki, N; Yoshida, H	1
Beffy, P; Masiello, P; Menegazzi, M; Novelli, M	1
Gu, W; Hao, XJ; Hu, ZX; Huang, LJ; Li, YN; Yuan, CM; Zeng, YR; Zhang, ZZ	1
Dall'Acqua, S; Pant, DR; Peron, G; Rajbhandary, S; Shrestha, SS	1
Li, CJ; Li, Y; Ma, J; Su, YL; Wang, AG; Zang, YD; Zhang, DM; Zhang, JJ	1
Chen, HF; Chen, JJ; Ding, R; Lin, T; Liu, XZ; Qiu, DR; Sun, CL; Tian, WJ; Wang, GH; Yu, FR; Zhou, M	1
Kong, L; Li, Q; Li, Y; Lu, W; Luo, J; Tang, P; Xu, W; Zhang, H; Zhang, M; Zhou, X	1
Dang, J; Ji, TF; Liu, B; Qiang, GF; Shi, MJ; Sun, H; Sun, HR; Suo, XY; Tao, YD; Wang, JJ; Wang, X; Yue, HL; Zhen, B	1
Bo, X; Chen, S; Cui, C; Guan, J; Han, J; Ke, X; Li, Z; Liu, C; Liu, H; Liu, J; Liu, X; Lu, J; Peng, C; Sun, H; Tan, C; Wang, R; Wu, P; Xu, X; Yang, D; Zhang, Y	1
Ji, TF; Jiang, JD; Lin, MB; Sun, HR; Suo, XY; Wang, JJ; Wang, X; Zhen, B	1
Gu, W; Hao, XJ; Hu, ZX; Huang, LJ; Li, YN; Yuan, CM; Zeng, YR	1
Fang, QQ; Feng, TT; He, WY; Lu, Q; Tan, CH; Wang, AZ; Wei, RJ	1
Bu, P; Cao, Y; Deng, Y; Duan, Y; Guo, Y; Qi, C; Shi, Z; Xie, S; Zhang, Y	1
Bu, P; Duan, Y; Guo, Y; Qi, C; Shi, Z; Xie, S; Zhang, Y	1
Ji, T; Jiang, J; Lin, M; Sun, H; Suo, X; Wang, J; Wang, X; Zhen, B	1
Kong, LY; Li, WX; Luo, J; Xu, WJ; Yang, L	1
Bálintová, M; Bruňáková, K; Čellárová, E; Henzelyová, J; Kimáková, A; Kolarčik, V; Petijová, L	1
Hou, AJ; Lei, C; Li, J; Zhang, MM; Zhou, YB; Zong, JF	1
Gu, Q; Peng, X; Tan, Q; Xu, J; Zhou, H	1
Grossman, RB; Ji, TF; Nie, XB; Wang, X; Yang, XW	1
Cao, Y; Chen, C; Guo, Y; Qi, C; Tong, Q; Yang, J; Zhang, Y; Zhu, H	1
Bu, P; Cao, Y; Deng, Y; Duan, Y; Guo, Y; Hu, H; Hu, Z; Qi, C; Shi, Z; Zhang, Y	1
Barda, C; Grafakou, ME; Heilmann, J; Lesjak, M; Pintać, D; Skaltsa, H	1
Guo, Y; Wang, YY; Zhang, YH; Zhao, XB	1
Heilmann, J; Max, J	1
Ao, Z; Chen, XL; He, YW; Kong, LY; Lu, JY; Luo, JG; Zhang, YX	1
Chen, J; Deng, L; Gu, W; Hao, XJ; He, W; Hu, ZX; Huang, LJ; Li, YN; Yang, J; Yi, P; Yuan, CM; Zeng, YR	1
Saçıcı, E; Yesilada, E	1
Hao, J; Song, P; Wang, Y; Yang, XZ	1
Imahori, D; Kitagawa, T; Kojima, N; Ohnishi, E; Ohta, T; Okayama, M; Watanabe, T; Yamashita, M; Yoshida, T; Μatsumoto, T	1
Ji, TF; Li, XX; Liu, B; Liu, XW; Liu, XY; Suo, XY; Zhu, TT	1
Cheng, H; Deng, J; Liu, Y; Wang, S; Yang, X; Zhang, L; Zhou, X	1
Albring, KF; Bloch, L; Huber, O; Knauthe, A; Mittag, S; Schmidt, M; Werz, O	1
Chen, G; Duan, Y; Feng, H; Guo, Y; Hu, H; Qi, C; Shi, Z; Sun, L; Tan, X; Zhang, N; Zhang, Y	1
Bu, P; Cao, Y; Duan, Y; Guo, Y; Hu, H; Hu, P; Qi, C; Shi, Z; Tong, Q; Zhang, Y	1
Chen, J; Malaco Morotti, AL; Tatsis, EC; Wang, G; Wang, S; Wang, Y; Wu, S; Xu, X	1
Gao, S; Gar-Lee Yue, G; Gomes, AJ; Hin-Fai Kwok, F; Jiang, NN; Kin-Ming Lee, J; Lau, CB; Li, P; Xu, G; Ye, YS	1
Deng, X; Hu, B; Liu, XS; Qian, MY; Wang, XR; Wu, L; Xia, J	1
Huang, YY; Huang, ZL; Mou, PY; Wei, X; Zeng, H; Zhou, ZB	1
Kong, LY; Li, XY; Li, YW; Lu, WJ; Tang, PF; Xu, WJ; Zhang, C; Zhou, X	1
Chen, H; Chen, JJ; Li, JD; Lin, T; Liu, XZ; Qiu, DR; Tian, WJ; Wang, GH; Zhou, M	1
Ji, T; Li, J; Li, X; Liu, B; Ma, Y; Suo, X; Zhu, T	1
Ji, T; Li, J; Li, P; Li, X; Liu, B; Liu, X; Ma, Y; Suo, X; Zhu, T	1
Chen, H; Cheng, H; Kang, X; Liu, W; Yang, X; Yao, Y; Zhao, P; Zhou, X	1
Alzheimer, C; Braeuning, A; El Hamdaoui, Y; Friedland, K; Fritz, N; Heinrich, M; Hellmich, UA; Lichtenstein, D; Müller, CP; Nowak, G; Nürnberg, B; Schäfer, MKE; Schirmeister, T; Schwickert, K; Tran, MA; Treccani, G; Weikert, D; Ye, L; Zheng, F	1
Chen, R; Dai, J; Liu, S; Yu, B	1
Jiang, NN; Li, SY; Liu, R; Nian, Y; Xu, G; Ye, YS	1
Ding, K; He, J; Li, XX; Pan, XG; Shi, YJ; Xia, CY; Xu, JK; Yan, Y; Zhang, J; Zhang, WK	1
Grossman, RB; Lan, T; Luo, Y; Qiu, YF; Xu, ZH; Yang, XW	1
Cao, TJ; Dong, RR; Kong, LY; Li, XY; Nan, MM; Wang, XL; Xu, WJ; Ying, P; Zheng, Q	1
Fan, YX; Ji, YY; Long, CL; Zhang, RF	1
Brankiewicz, A; Dziurka, M; Mrożek, M; Opydo, M; Pocheć, E; Szostak, E; Trzos, S; Tuleja, M; Łoboda, A	1
Hu, YL; Lau, CB; Li, XR; Xu, G; Yue, GG	1
Li, Y; Su, J; Sun, Z; Wang, M; Wang, Y; Zhao, Z	1
Grossman, RB; Qiu, YF; Yang, XW	1
Chen, G; Feng, H; Guo, J; Hao, X; Hou, Z; Qi, C; Shi, Z; Song, F; Sun, L; Tan, X; Wu, M; Xie, P; Zhang, Y; Zhao, X	1

Reviews

37 review(s) available for phloroglucinol and hypericum

Article	Year
St John's wort: Prozac from the plant kingdom. Trends in pharmacological sciences, 2001, Volume: 22, Issue:6 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Biological Availability; Bridged Bicyclo Compounds; Depression; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Leaves; Plants, Medicinal; Selective Serotonin Reuptake Inhibitors; Terpenes	2001
In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Electroshock; Fear; Hypericum; Locus Coeruleus; Neurotransmitter Agents; Phloroglucinol; Plant Extracts; Terpenes	2001
A current review of the antimicrobial activity of Hypericum perforatum L. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Humans; Hypericum; Phloroglucinol; Plant Extracts; Terpenes	2001
[Hyperforin in St. John's wort--drug, extraction and preparations]. Pharmazie in unserer Zeit, 2002, Volume: 31, Issue:5 Topics: Bridged Bicyclo Compounds; Drug Stability; Hypericum; Phloroglucinol; Terpenes	2002
Current St John's wort research from mode of action to clinical efficacy. Pharmacological research, 2003, Volume: 47, Issue:2 Topics: Animals; Antidepressive Agents; Behavior; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Norepinephrine; Phloroglucinol; Phytotherapy; Receptors, Serotonin; Serotonin; Synaptic Transmission; Terpenes	2003
Hypericum perforatum, a source of neuroactive lead structures. Current topics in medicinal chemistry, 2003, Volume: 3, Issue:2 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Depression; Humans; Hypericum; Mass Spectrometry; Phloroglucinol; Phytotherapy; Terpenes	2003
[Formulation of St. John's wort extract. A medicinal obstacle course]. Pharmazie in unserer Zeit, 2003, Volume: 32, Issue:3 Topics: Anthracenes; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Drug Compounding; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Solvents; Terpenes	2003
[Charge conformity and biopharmaceutic characterization. St. John's Wort extract preparations in comparison]. Pharmazie in unserer Zeit, 2003, Volume: 32, Issue:3 Topics: Animals; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Flavonoids; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2003
The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum). Biotechnology and applied biochemistry, 2004, Volume: 39, Issue:Pt 1 Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Culture Techniques; Hypericum; Perylene; Phloroglucinol; Plants, Medicinal; Terpenes	2004
The antidepressant mechanism of Hypericum perforatum. Life sciences, 2004, Jul-16, Volume: 75, Issue:9 Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neurotransmitter Agents; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Receptors, Dopamine D1; Receptors, Opioid; Terpenes	2004
Safety of Hypericum extract in mildly to moderately depressed outpatients: a review based on data from three randomized, placebo-controlled trials. Journal of affective disorders, 2004, Oct-15, Volume: 82, Issue:2 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypericum; Multicenter Studies as Topic; Phloroglucinol; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Risk; Terpenes	2004
Role of hyperforin in the pharmacological activities of St. John's Wort. CNS drug reviews, 2004,Fall, Volume: 10, Issue:3 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Disease Models, Animal; Drug Interactions; Humans; Hypericum; Phloroglucinol; Terpenes	2004
St. John's wort. American family physician, 2005, Dec-01, Volume: 72, Issue:11 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; Treatment Outcome	2005
Hyperforin: more than an antidepressant bioactive compound? Life sciences, 2006, Jun-06, Volume: 79, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Bridged Bicyclo Compounds; Humans; Hypericum; Phloroglucinol; Terpenes	2006
Hyperforin in St. John's wort drug interactions. European journal of clinical pharmacology, 2006, Volume: 62, Issue:3 Topics: Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Humans; Hypericum; Pharmaceutical Preparations; Phloroglucinol; Plants, Medicinal; Terpenes	2006
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clinical pharmacokinetics, 2006, Volume: 45, Issue:5 Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2006
Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine. Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 381, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Catechin; Humans; Hypericum; Matrix Metalloproteinases; Neovascularization, Pathologic; Phloroglucinol; Pulmonary Fibrosis; Tea; Terpenes	2007
[Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2007, Volume: 56, Issue:2 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes	2007
[New developments in hypericum extracts: data on efficacy and interactions]. Wiener medizinische Wochenschrift (1946), 2007, Volume: 157, Issue:13-14 Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Child; Citalopram; Depression; Double-Blind Method; Drug Interactions; Female; Fluoxetine; Humans; Hypericum; Male; Phloroglucinol; Phytotherapy; Placebos; Plant Extracts; Pregnancy; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Somatoform Disorders; Terpenes; Time Factors; Treatment Outcome	2007
St. John's wort: role of active compounds for its mechanism of action and efficacy. Wiener medizinische Wochenschrift (1946), 2007, Volume: 157, Issue:13-14 Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hypericum; Ice; Meta-Analysis as Topic; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2007
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. Journal of alternative and complementary medicine (New York, N.Y.), 2009, Volume: 15, Issue:8 Topics: Anthracenes; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bridged Bicyclo Compounds; Humans; Hypericum; Kava; Mood Disorders; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2009
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Current medicinal chemistry, 2010, Volume: 17, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cognition Disorders; Hypericum; Mice; Mice, Transgenic; Neuroprotective Agents; Phloroglucinol; Receptors, N-Methyl-D-Aspartate; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel	2010
St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects. Current drug metabolism, 2009, Volume: 10, Issue:9 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Nootropic Agents; Permeability; Perylene; Phloroglucinol; Plant Preparations; Psychotropic Drugs; Terpenes	2009
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular). Journal of natural products, 2010, May-28, Volume: 73, Issue:5 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Molecular Structure; Perylene; Phloroglucinol; Plant Preparations; Plants, Medicinal; Terpenes	2010
[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature]. L'Encephale, 2014, Volume: 40, Issue:2 Topics: Anthracenes; Antidepressive Agents; Brain; Hypericum; Neurons; Perylene; Phloroglucinol; Terpenes	2014
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phytotherapy research : PTR, 2014, Volume: 28, Issue:5 Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes	2014
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum. Critical reviews in food science and nutrition, 2014, Volume: 54, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Signal Transduction; Terpenes	2014
Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives. Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:10 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Humans; Hypericum; Phloroglucinol; Photosensitizing Agents; Terpenes	2014
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. Journal of affective disorders, 2017, Mar-01, Volume: 210 Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Terpenes	2017
Biotechnological production of hyperforin for pharmaceutical formulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 126 Topics: Biotechnology; Drug Compounding; Hypericum; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Plant Roots; Technology, Pharmaceutical; Terpenes	2018
Clinical risks of St John's Wort (Hypericum perforatum) co-administration. Expert opinion on drug metabolism & toxicology, 2017, Volume: 13, Issue:10 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Depression; Herb-Drug Interactions; Humans; Hypericum; Pharmacokinetics; Phloroglucinol; Plant Preparations; Terpenes	2017
Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Herb-Drug Interactions; Humans; Hypericum; Pharmacokinetics; Phloroglucinol; Plant Extracts; Terpenes	2019
Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species. Phytochemistry, 2018, Volume: 155 Topics: Analgesics; Animals; Anti-Bacterial Agents; Antidepressive Agents; Antineoplastic Agents, Phytogenic; Humans; Hypericum; Phloroglucinol	2018
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Genes, 2020, 10-16, Volume: 11, Issue:10 Topics: Anthracenes; Antidepressive Agents; Antineoplastic Agents; Europe; Humans; Hypericum; Perylene; Phloroglucinol; Phytochemicals; Plant Extracts; Plant Proteins; Terpenes	2020
Protective Role of St. John's Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies. International journal of molecular sciences, 2020, Oct-30, Volume: 21, Issue:21 Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypericum; Inflammation; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2020
Targeting the biological activity and biosynthesis of hyperforin: a mini-review. Chinese journal of natural medicines, 2022, Volume: 20, Issue:10 Topics: Hypericum; Molecular Structure; Phloroglucinol; Terpenes	2022
Hyperforin: A natural lead compound with multiple pharmacological activities. Phytochemistry, 2023, Volume: 206 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Hypericum; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes	2023

Trials

18 trial(s) available for phloroglucinol and hypericum

Article	Year
Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Administration, Oral; Adult; Animals; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes; Xanthenes	1998
Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Adult; Anthracenes; Bridged Bicyclo Compounds; Cerebral Cortex; Electroencephalography; Female; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes	1998
St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes	1998
Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells. The British journal of dermatology, 2000, Volume: 142, Issue:5 Topics: Adjuvants, Immunologic; Administration, Topical; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Cell Division; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Humans; Hypericum; Immunity, Cellular; Immunosuppressive Agents; Isoantigens; Leukocytes, Mononuclear; Phloroglucinol; Plants, Medicinal; Prospective Studies; T-Lymphocytes; Terpenes	2000
Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2000, Volume: 7, Issue:6 Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gelatin; Humans; Hypericum; Male; Mass Spectrometry; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Reference Values; Terpenes	2000
Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy male volunteers. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Adult; Antidepressive Agents; Blood Pressure; Bridged Bicyclo Compounds; Dopamine; Heart Rate; Human Growth Hormone; Humans; Hydrocortisone; Hypericum; Male; Neurosecretory Systems; Norepinephrine; Phloroglucinol; Plant Extracts; Prolactin; Serotonin; Terpenes	2001
Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Bridged Bicyclo Compounds; Corticosterone; Cross-Over Studies; Double-Blind Method; Humans; Hypericum; Ketanserin; Male; Middle Aged; Neurosecretory Systems; Perylene; Phloroglucinol; Piperazines; Plant Extracts; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Terpenes	2001
[Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2003, Volume: 54, Issue:3 Topics: Adolescent; Adult; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Child; Colony Count, Microbial; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Ointments; Phloroglucinol; Phytotherapy; Plant Extracts; Prospective Studies; Staphylococcal Skin Infections; Staphylococcus aureus; Terpenes	2003
Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4 Topics: Adult; Antidepressive Agents; Area Under Curve; Bridged Bicyclo Compounds; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Humans; Hypericum; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes	2004
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Arzneimittel-Forschung, 2005, Volume: 55, Issue:1 Topics: Adolescent; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes	2005
Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial. Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:3 Topics: Adult; Biomarkers; Bridged Bicyclo Compounds; Chi-Square Distribution; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; National Institutes of Health (U.S.); Patient Compliance; Phloroglucinol; Statistics, Nonparametric; Terpenes; United States	2005
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. Arzneimittel-Forschung, 2005, Volume: 55, Issue:10 Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes	2005
The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose. European journal of clinical pharmacology, 2006, Volume: 62, Issue:1 Topics: Adult; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Extracts; Tablets; Terpenes	2006
Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2008, Volume: 37, Issue:7 Topics: Aged; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Statistics, Nonparametric; Terpenes; Treatment Outcome	2008
No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers. European journal of clinical pharmacology, 2009, Volume: 65, Issue:1 Topics: Administration, Oral; Adult; Bridged Bicyclo Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Preparations; Powders; Substrate Specificity; Terpenes; Young Adult	2009
In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 81, Issue:2 Topics: Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Antioxidants; Double-Blind Method; Erythema; Female; Free Radical Scavengers; Humans; Hypericum; Inflammation; Keratinocytes; Male; Middle Aged; Phloroglucinol; Plant Extracts; Skin; Swine; Terpenes; Ultraviolet Rays; Young Adult	2012
Radical protection in the visible and infrared by a hyperforin-rich cream--in vivo versus ex vivo methods. Experimental dermatology, 2013, Volume: 22, Issue:5 Topics: Administration, Topical; Adult; Animals; Antioxidants; Double-Blind Method; Electron Spin Resonance Spectroscopy; Female; Humans; Hypericum; Infrared Rays; Light; Male; Phloroglucinol; Placebos; Skin Cream; Swine; Terpenes; Young Adult	2013
No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein. Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:2 Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Hypericum; Male; Phloroglucinol; Plant Extracts; Psychotropic Drugs; Terpenes	2019

Other Studies

346 other study(ies) available for phloroglucinol and hypericum

Article	Year
Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Hypericum; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Terpenes; Xanthenes	1998
Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Animals; Brain; Bridged Bicyclo Compounds; Dopamine; Female; Hypericum; Male; Mice; Monoamine Oxidase; Neurotransmitter Uptake Inhibitors; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Synaptosomes; Terpenes; Xanthenes	1998
Activity profiles of two hyperforin-containing hypericum extracts in behavioral models. Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds; Hypericum; Male; Mice; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Stereotyped Behavior; Terpenes; Xanthenes	1998
Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Pharmacopsychiatry, 1998, Volume: 31 Suppl 1 Topics: Animals; Brain; Bridged Bicyclo Compounds; Carbon Dioxide; Electrodes, Implanted; Electroencephalography; Hypericum; Male; Methanol; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Terpenes; Xanthenes	1998
Hyperforin as a possible antidepressant component of hypericum extracts. Life sciences, 1998, Volume: 63, Issue:6 Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Helplessness, Learned; Hypericum; Male; Models, Chemical; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Synaptosomes; Terpenes; Xanthenes	1998
New phloroglucinol derivatives from Hypericum papuanum. Journal of natural products, 2000, Volume: 63, Issue:1 Topics: Anti-Bacterial Agents; Bacteria; Hypericum; Microbial Sensitivity Tests; Phloroglucinol; Plants, Medicinal; Spectrum Analysis	2000
Measurement of hyperforin a constituent of St. John's wort in plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1999, Dec-10, Volume: 735, Issue:2 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Hypericum; Male; Phloroglucinol; Plants, Medicinal; Rats; Reproducibility of Results; Spectrophotometry, Ultraviolet; Terpenes	1999
Phloroglucinol derivatives from Hypericum japonicum. Phytochemistry, 2000, Volume: 53, Issue:6 Topics: Crystallography, X-Ray; Drugs, Chinese Herbal; Hypericum; Magnetic Resonance Spectroscopy; Phloroglucinol; Plants, Medicinal	2000
Hyperforin analogues from St. John's wort (Hypericum perforatum). Journal of natural products, 2000, Volume: 63, Issue:3 Topics: Bridged Bicyclo Compounds; Hypericum; Molecular Structure; Phloroglucinol; Plants, Medicinal; Spectrum Analysis; Terpenes	2000
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jun-20, Volume: 97, Issue:13 Topics: Bridged Bicyclo Compounds; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypericum; Ligands; Liver; Mixed Function Oxygenases; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Terpenes	2000
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:1 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes	2000
Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:2 Topics: Animals; Biological Transport; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Ionophores; Mice; Mice, Inbred Strains; Monensin; Neurotransmitter Uptake Inhibitors; Ouabain; Phloroglucinol; Plants, Medicinal; Sodium Channels; Synaptosomes; Terpenes	2000
St. John's Wort: is it effective and harmless? RDH, 1999, Volume: 19, Issue:6 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes	1999
Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Calcium Channel Blockers; Calcium Channels, P-Type; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hypericum; Ion Channel Gating; Membrane Potentials; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phloroglucinol; Plants, Medicinal; Purkinje Cells; Rats; Rats, Wistar; Second Messenger Systems; Terpenes; Thionucleotides	2000
St John's wort, a herbal antidepressant, activates the steroid X receptor. The Journal of endocrinology, 2000, Volume: 166, Issue:3 Topics: Animals; Anthracenes; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Bridged Bicyclo Compounds; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Histone Acetyltransferases; Humans; Hypericum; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Perylene; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Protein Binding; Receptors, Steroid; Rifampin; Terpenes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured	2000
Hyperforin in extracts of St John's wort (Hypericum perforatum) for depression. Archives of internal medicine, 2000, Sep-11, Volume: 160, Issue:16 Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plants, Medicinal; Terpenes	2000
Three new hyperforin analogues from Hypericum perforatum. Journal of natural products, 2001, Volume: 64, Issue:1 Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phloroglucinol; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Terpenes	2001
Pharmacology. How the body's 'garbage disposal' may inactivate drugs. Science (New York, N.Y.), 2001, Jan-05, Volume: 291, Issue:5501 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bridged Bicyclo Compounds; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hypericum; Liver; Mice; Mice, Knockout; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Terpenes; Transcription Factors; Xenobiotics	2001
Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum. Planta medica, 2000, Volume: 66, Issue:8 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Molecular Structure; Phloroglucinol; Plants, Medicinal; Terpenes	2000
Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life sciences, 2001, Feb-23, Volume: 68, Issue:14 Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Chromatography, Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Hypericum; In Vitro Techniques; Male; Norepinephrine; Phloroglucinol; Plants, Medicinal; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes	2001
St John's Wort and literature quotations. Archives of internal medicine, 2001, Apr-09, Volume: 161, Issue:7 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Bridged Bicyclo Compounds; Depression; Dopamine; Drug Interactions; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plants, Medicinal; Serotonin; Terpenes; Treatment Outcome	2001
New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum. Journal of natural products, 2001, Volume: 64, Issue:6 Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bacteria; Humans; Hypericum; KB Cells; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Weight; Phloroglucinol; Plants, Medicinal; Protein Prenylation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet	2001
Effect of St. John's wort on free radical production. Life sciences, 2001, Jun-01, Volume: 69, Issue:2 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Free Radicals; Humans; Hypericum; Indicators and Reagents; Perylene; Phloroglucinol; Placenta; Plant Extracts; Plants, Medicinal; Pregnancy; Superoxides; Terpenes; Veins	2001
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes	2001
Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; Hypericum; Imipramine; Male; Methanol; Microdialysis; Neurons; Nucleus Accumbens; Phloroglucinol; Plant Extracts; Rats; Rats, Inbred Strains; Serotonin; Solvents; Terpenes	2001
In vitro effects of St. John's wort extract and hyperforin on 5 HT uptake and efflux in human blood platelets. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Blood Platelets; Bridged Bicyclo Compounds; Cyclohexanols; Humans; Hypericum; In Vitro Techniques; Phloroglucinol; Plant Extracts; Reserpine; Serotonin; Terpenes; Venlafaxine Hydrochloride	2001
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Male; Neurotransmitter Agents; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes	2001
Batch-to-batch reproducibility of St. John's wort preparations. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Reproducibility of Results; Terpenes	2001
A study of the antidepressant activity of Hypericum perforatum on animal models. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Chronic Disease; Depression; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electroshock; Fluoxetine; Hypericum; Imipramine; Microdialysis; Phloroglucinol; Plant Extracts; Rats; Stress, Physiological; Terpenes	2001
In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Anthracenes; Antidepressive Agents; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Flavonoids; Hypericum; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Perylene; Phloroglucinol; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neuropeptide Y; Receptors, Serotonin; Receptors, sigma; Terpenes	2001
Hypericum extract and hyperforin: memory-enhancing properties in rodents. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Amnesia; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bridged Bicyclo Compounds; Hypericum; Male; Memory; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Scopolamine; Terpenes	2001
Interleukin-6 involvement in antidepressant action of Hypericum perforatum. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Diencephalon; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Hypericum; Immune System; Interleukin-6; Male; Mice; Mice, Knockout; Perylene; Phloroglucinol; Plant Extracts; Rutin; Serotonin; Swimming; Terpenes; Tryptophan	2001
Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antidepressive Agents; Bicuculline; Bridged Bicyclo Compounds; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Guinea Pigs; Hippocampus; Hypericum; Organ Culture Techniques; Phloroglucinol; Plant Extracts; Terpenes	2001
Hyperforin--antidepressant activity by a novel mechanism of action. Pharmacopsychiatry, 2001, Volume: 34 Suppl 1 Topics: Animals; Antidepressive Agents; Binding, Competitive; Bridged Bicyclo Compounds; Hydrogen-Ion Concentration; Hypericum; Mice; Phloroglucinol; Plant Extracts; Serotonin; Sodium; Sodium Channels; Sodium-Hydrogen Exchangers; Synaptosomes; Terpenes; Tritium	2001
Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. Drug development and industrial pharmacy, 2001, Volume: 27, Issue:6 Topics: Algorithms; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Drug Storage; Flavonoids; Hypericum; Parasympatholytics; Perylene; Phloroglucinol; Plant Extracts; Solvents; Sunlight	2001
High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products. Journal of chromatography. A, 2001, Aug-10, Volume: 926, Issue:1 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Terpenes	2001
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations. Journal of pharmaceutical and biomedical analysis, 2001, Volume: 26, Issue:5-6 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Solutions; Terpenes	2001
Chemical and pharmacological evaluation of Hypericum perforatum extracts. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:12 Topics: Animals; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Free Radical Scavengers; Hippocampus; Hypericum; Male; Perylene; Phloroglucinol; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Terpenes	2000
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow. Journal of pharmaceutical and biomedical analysis, 2002, Jan-01, Volume: 27, Issue:1-2 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Electrolytes; Electrophoresis, Capillary; Hypericum; Molecular Structure; Osmotic Pressure; Perylene; Phloroglucinol; Plant Extracts; Reproducibility of Results; Rheology; Solvents; Terpenes	2002
Is St John's wort a 'Prozac-like' herbal antidepressant? Trends in pharmacological sciences, 2001, Volume: 22, Issue:11 Topics: Animals; Bridged Bicyclo Compounds; Fluoxetine; Humans; Hypericum; Phloroglucinol; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Terpenes	2001
Attractive and defensive functions of the ultraviolet pigments of a flower (Hypericum calycinum). Proceedings of the National Academy of Sciences of the United States of America, 2001, Nov-20, Volume: 98, Issue:24 Topics: Animals; Hypericum; Insect Repellents; Molecular Structure; Moths; Pheromones; Phloroglucinol; Pigments, Biological; Ultraviolet Rays	2001
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene, 2002, Feb-14, Volume: 21, Issue:8 Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Caspases; Cell Division; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Hypericum; Intracellular Membranes; Microscopy, Electron; Mitochondria; Neoplasms; Phloroglucinol; Rats; Staurosporine; Terpenes; Time Factors; Tumor Cells, Cultured	2002
Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2002, Volume: 16, Issue:5 Topics: Anthraquinones; Calibration; Cells, Cultured; Chromatography, High Pressure Liquid; Hypericum; Indicators and Reagents; Mass Spectrometry; Phloroglucinol; Plant Extracts; Quality Control	2002
Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse. Life sciences, 2002, Feb-01, Volume: 70, Issue:11 Topics: Alanine Transaminase; Animals; Anthracenes; Antidepressive Agents; Body Weight; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Hypericum; Isoenzymes; Liver; Male; Mice; Perylene; Phloroglucinol; Plant Preparations; Terpenes	2002
Determining hyperforin and hypericin content in eight brands of St. John's wort. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Mar-15, Volume: 59, Issue:6 Topics: Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dosage Forms; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes	2002
Benzoylphloroglucinol derivatives from Hypericum scabrum. Journal of natural products, 2002, Volume: 65, Issue:3 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Resistance, Microbial; Hypericum; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plants, Medicinal; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Uzbekistan	2002
Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2 Topics: Acetylcholine; Animals; Anti-Bacterial Agents; Biological Transport; Bridged Bicyclo Compounds; Choline; Corpus Striatum; Hypericum; Motor Activity; Phloroglucinol; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Terpenes	2002
Regulating natural health products. Science (New York, N.Y.), 2002, Apr-05, Volume: 296, Issue:5565 Topics: Bridged Bicyclo Compounds; Drug Interactions; Drug Labeling; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; United States	2002
Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety. Journal of natural products, 2002, Volume: 65, Issue:4 Topics: Animals; Brain; Bridged Bicyclo Compounds; Chromatography, Thin Layer; Cyclohexanes; Dopamine Antagonists; Hypericum; Inhibitory Concentration 50; Molecular Conformation; Phloroglucinol; Plants, Medicinal; Rats; Receptors, Neurotransmitter; Selective Serotonin Reuptake Inhibitors; Spectrophotometry, Infrared; Structure-Activity Relationship; Terpenes	2002
Supercritical fluid extraction and high-performance liquid chromatographic determination of phloroglucinols in St. John's Wort (Hypericum perforatum L.). Journal of agricultural and food chemistry, 2002, May-08, Volume: 50, Issue:10 Topics: Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Hypericum; Phloroglucinol; Sensitivity and Specificity	2002
Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy. Journal of pharmaceutical and biomedical analysis, 2002, May-15, Volume: 28, Issue:3-4 Topics: Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Multivariate Analysis; Phloroglucinol; Plant Extracts; Reference Standards; Spectrophotometry, Ultraviolet; Spectroscopy, Near-Infrared; Terpenes	2002
Antidepressant activity of hyperforin conjugates of the St. John's wort, Hypericum perforatum Linn.: an experimental study. Indian journal of experimental biology, 2001, Volume: 39, Issue:12 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Female; Hypericum; Male; Phloroglucinol; Plant Extracts; Rats; Swimming; Terpenes	2001
Inhibition of vesicular uptake of monoamines by hyperforin. Life sciences, 2002, Sep-27, Volume: 71, Issue:19 Topics: Animals; Anti-Bacterial Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Fluoxetine; Hypericum; Male; Neurotransmitter Uptake Inhibitors; Phloroglucinol; Piperazines; Plant Extracts; Prosencephalon; Rats; Synaptosomes; Terpenes	2002
Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Sep-25, Volume: 777, Issue:1-2 Topics: Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Reproducibility of Results; Terpenes	2002
Biosynthesis of hyperforin in Hypericum perforatum. Journal of medicinal chemistry, 2002, Oct-10, Volume: 45, Issue:21 Topics: Bridged Bicyclo Compounds; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Terpenes	2002
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochemical pharmacology, 2002, Dec-15, Volume: 64, Issue:12 Topics: Anti-Bacterial Agents; Arachidonate 5-Lipoxygenase; Blood Platelets; Bridged Bicyclo Compounds; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Inhibitors; Humans; Hypericum; Isoenzymes; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Membrane Proteins; Phloroglucinol; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Terpenes	2002
Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology, 2002, Volume: 164, Issue:4 Topics: Animals; Antidepressive Agents; Arousal; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Cyclohexylamines; Dose-Response Relationship, Drug; Exploratory Behavior; Hypericum; Male; Motor Activity; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Terpenes	2002
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem). Planta medica, 2002, Volume: 68, Issue:12 Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes	2002
Biorelevant dissolution testing of St John's wort products. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:12 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Ethanol; Hypericum; Kinetics; Methanol; Phloroglucinol; Plant Extracts; Quercetin; Reproducibility of Results; Rutin; Solubility; Solvents; Terpenes; Time Factors	2002
[Dangerous interaction of St. John's wort with chemotherapy?]. Pharmazie in unserer Zeit, 2003, Volume: 32, Issue:1 Topics: Anthracenes; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Terpenes	2003
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry, 2003, Feb-18, Volume: 42, Issue:6 Topics: Animals; Antidepressive Agents; Binding Sites; Biopolymers; Bridged Bicyclo Compounds; Cell Line; Cells, Cultured; Chlorocebus aethiops; Computer Simulation; Crystallization; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Humans; Hypericum; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Phloroglucinol; Pregnane X Receptor; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Structure-Activity Relationship; Terpenes; Transfection	2003
Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species. Planta medica, 2003, Volume: 69, Issue:3 Topics: Antioxidants; Humans; Hypericum; Luminescent Measurements; Neutrophil Activation; Neutrophils; Phloroglucinol; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Respiratory Burst	2003
Variability in phenolic composition of Hypericum androsaemum. Natural product research, 2003, Volume: 17, Issue:2 Topics: Chromatography, High Pressure Liquid; Humans; Hypericum; Phenols; Phloroglucinol; Phytotherapy; Plant Extracts; Plant Leaves	2003
Treatment with Hypericum perforatum L. does not trigger decreased resistance in Staphylococcus aureus against antibiotics and hyperforin. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2003, Volume: 10, Issue:2-3 Topics: Bridged Bicyclo Compounds; Drug Resistance, Bacterial; Hypericum; Microbial Sensitivity Tests; Penicillins; Phloroglucinol; Plant Extracts; Staphylococcus aureus; Terpenes	2003
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models. Life sciences, 2003, Jun-20, Volume: 73, Issue:5 Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Female; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phloroglucinol; Physical Exertion; Plant Extracts; Rats; Rats, Inbred Strains; Swimming; Terpenes	2003
Further degradation product of hyperforin from Hypericum perforatum (St John's Wort). Fitoterapia, 2003, Volume: 74, Issue:5 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacillus subtilis; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Candida albicans; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Hypericum; Microbial Sensitivity Tests; Phloroglucinol; Phytotherapy; Plant Extracts; Staphylococcus aureus; Terpenes	2003
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2003, Volume: 56, Issue:1 Topics: Annexin A5; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Astrocytes; Biflavonoids; Bridged Bicyclo Compounds; Caspases; Catechin; Cell Division; Cell Line, Tumor; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Proanthocyanidins; Terpenes	2003
Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:1 Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phloroglucinol; Plant Extracts; Terpenes; Time Factors	2003
Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:12 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Antidepressive Agents; Body Weight; Brain; Bridged Bicyclo Compounds; Corticosterone; Drug Interactions; Hypericum; Hypothalamo-Hypophyseal System; Immunohistochemistry; In Situ Hybridization; Male; Organ Size; Phloroglucinol; Phosphoproteins; Pituitary-Adrenal System; Plant Extracts; Pro-Opiomelanocortin; Radioimmunoassay; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Terpenes; Time Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase	2003
Comparison of the growth-inhibitory effect of Hypericum perforatum L. extracts, differing in the concentration of phloroglucinols and flavonoids, on leukaemia cells. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Cell Division; Chromatography, High Pressure Liquid; Flavonoids; Humans; Hypericum; Inhibitory Concentration 50; K562 Cells; Light; Phloroglucinol; Plant Extracts; Terpenes; U937 Cells	2003
Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericumatomarium ssp. degenii. Journal of natural products, 2003, Volume: 66, Issue:9 Topics: Anti-Infective Agents; Bacillus subtilis; Gram-Positive Bacteria; Hyperbaric Oxygenation; Hypericum; Microbial Sensitivity Tests; Micrococcus luteus; Molecular Structure; Phloroglucinol; Plants, Medicinal; Siberia; Staphylococcus aureus	2003
A simple and reliable semipreparative high-performance liquid chromatography technique for the isolation of marker-grade hyperforin from Hypericum perforatum L extract. Journal of chromatographic science, 2003, Volume: 41, Issue:8 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Mass Spectrometry; Phloroglucinol; Plant Extracts; Reproducibility of Results; Terpenes	2003
Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. Pharmacopsychiatry, 2003, Volume: 36, Issue:6 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Hypericum; Imipramine; Male; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Stress, Psychological; Terpenes	2003
Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex. Life sciences, 2004, Jan-09, Volume: 74, Issue:8 Topics: Animals; Anthracenes; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Cell Membrane; Fluoxetine; Frontal Lobe; Hypericum; Imipramine; Male; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Terpenes	2004
Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study. Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:4 Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Stability; Ethanol; Hypericum; Male; Mice; Mice, Inbred C57BL; Phloroglucinol; Phytotherapy; Plant Extracts; Plant Structures; Terpenes; Time Factors	2003
Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores. Journal of chemical ecology, 2003, Volume: 29, Issue:12 Topics: Adaptation, Physiological; Animals; Anthracenes; Anti-Bacterial Agents; Biological Assay; Bridged Bicyclo Compounds; Coleoptera; Enzyme Inhibitors; Feeding Behavior; Hypericum; Larva; Moths; Perylene; Phloroglucinol; Plants, Edible; Terpenes	2003
Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:1 Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Flow Cytometry; Genes, MDR; Herb-Drug Interactions; Humans; Hypericum; Mice; NIH 3T3 Cells; Perylene; Phloroglucinol; Terpenes	2004
Enrichment of hyperforin from St. John's wort (Hypericum perforatum) by pilot-scale supercritical carbon dioxide extraction. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 21, Issue:4 Topics: Bridged Bicyclo Compounds; Calibration; Carbon Dioxide; Chromatography, Supercritical Fluid; Hypericum; Phloroglucinol; Plant Extracts; Pressure; Temperature; Terpenes	2004
Proteome analysis reveals a distinct molecular profile of cellular stress following incubation of DDT1-MF2 smooth muscle cells in the presence of a high concentration of hyperforin. Planta medica, 2004, Volume: 70, Issue:4 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Cricetinae; Electrophoresis, Gel, Two-Dimensional; Hypericum; Male; Mesocricetus; Muscle, Smooth; Phloroglucinol; Phytotherapy; Plant Extracts; Proteome; Stress, Physiological; Terpenes; Vas Deferens	2004
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:5 Topics: Bridged Bicyclo Compounds; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Humans; Hypericum; Phloroglucinol; RNA, Messenger; Terpenes	2004
Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort. Neuroscience letters, 2004, Jul-08, Volume: 364, Issue:3 Topics: Acetylcholine; Anesthetics, Local; Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Hippocampus; Hypericum; Microdialysis; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; Terpenes; Tetrodotoxin	2004
Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures. Journal of natural products, 2004, Volume: 67, Issue:6 Topics: Antioxidants; Biphenyl Compounds; Cells, Cultured; Chromans; Free Radical Scavengers; Greece; Hypericum; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Picrates; Plants, Medicinal; Reactive Oxygen Species	2004
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro. Urology, 2004, Volume: 64, Issue:1 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil	2004
Development of a high-performance liquid chromatographic method with electrochemical detection for the determination of hyperforin. Journal of chromatography. A, 2004, Jul-02, Volume: 1041, Issue:1-2 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Electrochemistry; Hypericum; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Terpenes	2004
In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Planta medica, 2004, Volume: 70, Issue:7 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cyclohexylamines; Female; Humans; Hypericum; Inhibitory Concentration 50; Interleukin-6; Male; Models, Animal; Models, Biological; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Terpenes	2004
Hyperforin modifies neuronal membrane properties in vivo. Neuroscience letters, 2004, Sep-02, Volume: 367, Issue:2 Topics: Administration, Oral; Animals; Anisotropy; Brain; Brain Chemistry; Bridged Bicyclo Compounds; Cell Membrane; Chromatography, Liquid; Diphenylhexatriene; Dose-Response Relationship, Drug; Female; Hypericum; Membrane Fluidity; Mice; Neurons; Phloroglucinol; Plant Extracts; Pyrenes; Terpenes	2004
Undeclared exposure to St. John's Wort in hospitalized patients. British journal of clinical pharmacology, 2004, Volume: 58, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Bridged Bicyclo Compounds; Drug Interactions; Hospitalization; Humans; Hypericum; Middle Aged; Perylene; Phloroglucinol; Self Medication; Substance Abuse Detection; Terpenes	2004
Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage. Journal of agricultural and food chemistry, 2004, Oct-06, Volume: 52, Issue:20 Topics: Beverages; Bridged Bicyclo Compounds; Drug Stability; Hydrogen-Ion Concentration; Hypericum; Molecular Structure; Phloroglucinol; Solutions; Terpenes; Water	2004
Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin. The Journal of organic chemistry, 2004, Nov-12, Volume: 69, Issue:23 Topics: Bridged Bicyclo Compounds; Horseradish Peroxidase; Hydrogen Peroxide; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovalbumin; Oxidation-Reduction; Phloroglucinol; Proteins; Serum Albumin; Terpenes	2004
Air/light-free hyphenated extraction/analysis system: supercritical fluid extraction on-line coupled with liquid chromatography-UV absorbance/electrospray mass spectrometry for the determination of hyperforin and its degradation products in Hypericum pert Analytical chemistry, 2004, Nov-15, Volume: 76, Issue:22 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Hypericum; Light; Oxygen; Phloroglucinol; Spectrometry, Mass, Electrospray Ionization; Terpenes	2004
Modulation of P-glycoprotein function by St John's wort extract and its major constituents. Pharmacopsychiatry, 2004, Volume: 37, Issue:6 Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Bridged Bicyclo Compounds; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Fluoresceins; Fluoxetine; Herb-Drug Interactions; Humans; Hypericum; Leukemia; Models, Biological; Phloroglucinol; Plant Extracts; Quercetin; Swine; Terpenes	2004
Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway. Journal of clinical immunology, 2004, Volume: 24, Issue:6 Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Cell Line; Gene Expression Regulation; Humans; Hypericum; Inflammation Mediators; Interleukin-8; Intestinal Mucosa; Mitogen-Activated Protein Kinases; NF-kappa B; Phloroglucinol; Phytotherapy; Signal Transduction; Terpenes; Transcription Factor AP-1	2004
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:4 Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bridged Bicyclo Compounds; Cell Line, Tumor; Colonic Neoplasms; Digoxin; Humans; Hypericum; LLC-PK1 Cells; Perylene; Phloroglucinol; Plant Extracts; Rifampin; Swine; Terpenes; Transfection	2005
The first prenylation step in hyperforin biosynthesis. Phytochemistry, 2005, Volume: 66, Issue:1 Topics: Bridged Bicyclo Compounds; Dimethylallyltranstransferase; Hydrogen-Ion Concentration; Hypericum; Iron; Molecular Structure; Phloroglucinol; Protein Prenylation; Solubility; Substrate Specificity; Temperature; Terpenes	2005
Biosynthesis of the hyperforin skeleton in Hypericum calycinum cell cultures. Phytochemistry, 2005, Volume: 66, Issue:2 Topics: Acyltransferases; Bridged Bicyclo Compounds; Carbon-Carbon Ligases; Cells, Cultured; Hypericum; Molecular Structure; Phloroglucinol; Polyketide Synthases; Terpenes; Time Factors	2005
Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:2 Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Esters; Hypericum; Immobilization; Male; Phloroglucinol; Plant Extracts; Protein Binding; Rats; Stress, Physiological; Terpenes	2005
Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation. Journal of pharmaceutical and biomedical analysis, 2005, Feb-23, Volume: 37, Issue:2 Topics: Chromatography, High Pressure Liquid; Drug Stability; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Hypericum; Light; Methanol; Molecular Structure; Perylene; Phloroglucinol; Plant Extracts	2005
Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility. The Journal of urology, 2005, Volume: 173, Issue:6 Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ejaculation; Humans; Hypericum; Isometric Contraction; Male; Muscle, Smooth; Orgasm; Perylene; Phloroglucinol; Rats; Terpenes; Tissue Culture Techniques; Vas Deferens	2005
Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems. Angewandte Chemie (International ed. in English), 2005, Jun-20, Volume: 44, Issue:25 Topics: Bridged Bicyclo Compounds; Crystallography, X-Ray; Hypericum; Ketones; Models, Chemical; Models, Molecular; Molecular Conformation; Phloroglucinol; Stereoisomerism; Terpenes	2005
Benzophenones from Hypericum carinatum. Journal of natural products, 2005, Volume: 68, Issue:5 Topics: Antioxidants; Benzophenones; Brazil; Dose-Response Relationship, Drug; Hypericum; Luminescent Measurements; Molecular Structure; Phloroglucinol; Plant Leaves; Plants, Medicinal; Quercetin	2005
An anti-staphylococcal acylphloroglucinol from Hypericum foliosum. Phytochemistry, 2005, Volume: 66, Issue:12 Topics: Anti-Bacterial Agents; Epoxy Compounds; Hypericum; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Staphylococcus aureus	2005
Hyperforin, a bio-active compound of St. John's Wort, is a new inhibitor of angiogenesis targeting several key steps of the process. International journal of cancer, 2005, Dec-10, Volume: 117, Issue:5 Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Bridged Bicyclo Compounds; Cattle; Cell Division; Cell Line, Tumor; Cells, Cultured; Endothelium, Vascular; Extracellular Matrix; Humans; Hypericum; Mice; Neovascularization, Physiologic; Phloroglucinol; Terpenes	2005
Bioassay-guided isolation of antimicrobial benzopyrans and phloroglucinol derivatives from Hypericum species. Phytotherapy research : PTR, 2005, Volume: 19, Issue:4 Topics: Anti-Bacterial Agents; Benzopyrans; Biological Assay; Humans; Hypericum; Microbial Sensitivity Tests; Phloroglucinol; Phytotherapy; Plant Extracts; Staphylococcus aureus	2005
Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats. Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:5 Topics: Administration, Oral; Alcohol Drinking; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drinking; Eating; Hypericum; Injections, Intraperitoneal; Male; Naltrexone; Narcotic Antagonists; Phloroglucinol; Plant Extracts; Rats; Terpenes; Time Factors; Treatment Outcome	2005
Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 1 Topics: Aged; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Bridged Bicyclo Compounds; Chromatography, Liquid; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Docetaxel; Drug Synergism; Female; Hepatocytes; Humans; Hypericum; Ions; Liver; Mass Spectrometry; Middle Aged; Models, Chemical; Phloroglucinol; Rifampin; Taxoids; Terpenes; Time Factors	2005
St. John's wort and its constituent hyperforin concordantly regulate expression of genes encoding enzymes involved in basic cellular pathways. Pharmacogenetics and genomics, 2005, Volume: 15, Issue:11 Topics: Base Sequence; Bridged Bicyclo Compounds; Calcium; Cell Hypoxia; Cell Line; Cholesterol; Gene Expression Regulation, Enzymologic; Glucose; Glycolysis; Humans; Hypericum; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Phloroglucinol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; Xenobiotics	2005
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:12 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes	2005
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors. The journal of medical investigation : JMI, 2005, Volume: 52 Suppl Topics: Animals; Anthracenes; Biflavonoids; Bridged Bicyclo Compounds; Carrier Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Fluoxetine; Fluvoxamine; Food; Hypericum; Ligands; Macrophages; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Osteoclasts; Perylene; Phloroglucinol; Plant Extracts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Serotonin; Stress, Physiological; Terpenes; Time Factors	2005
St. John's wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 mothers and 2 infants. The Journal of clinical psychiatry, 2006, Volume: 67, Issue:2 Topics: Adult; Breast Feeding; Bridged Bicyclo Compounds; Depressive Disorder; Female; Humans; Hypericum; Infant; Mass Spectrometry; Maternal Exposure; Maternal-Fetal Exchange; Milk, Human; Phloroglucinol; Phytotherapy; Plant Preparations; Pregnancy; Terpenes	2006
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L. Journal of agricultural and food chemistry, 2006, Apr-05, Volume: 54, Issue:7 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Sonication; Terpenes	2006
Phytotherapy: rarely mentioned spontaneously. Prescrire international, 2006, Volume: 15, Issue:82 Topics: Bridged Bicyclo Compounds; Disclosure; Drug Interactions; Humans; Hypericum; Medical History Taking; Phloroglucinol; Phytotherapy; Terpenes	2006
Evaluation of hyperforin analogues for inhibition of 5-lipoxygenase. Medicinal chemistry (Shariqah (United Arab Emirates)), 2005, Volume: 1, Issue:3 Topics: Bridged Bicyclo Compounds; Cells, Cultured; Enzyme Inhibitors; Humans; Hypericum; Lipoxygenase Inhibitors; Neutrophils; Phloroglucinol; Terpenes	2005
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits. Molecular psychiatry, 2006, Volume: 11, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Analysis of Variance; Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Escape Reaction; Hippocampus; Hypericum; Male; Maze Learning; Microinjections; Neuroprotective Agents; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Terpenes; Time Factors	2006
Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin. Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:18 Topics: Bridged Bicyclo Compounds; Hypericum; Molecular Structure; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Terpenes	2006
NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort. Journal of pharmacological sciences, 2006, Volume: 102, Issue:1 Topics: Animals; Brain Edema; Brain Ischemia; Bridged Bicyclo Compounds; Calcium; Choline; Hippocampus; Hypericum; In Vitro Techniques; Male; Microscopy, Fluorescence; Neuroprotective Agents; Phloroglucinol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Terpenes; Water Intoxication	2006
Hyperforin. Phytochemistry, 2006, Volume: 67, Issue:20 Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Hypericum; Neurotransmitter Uptake Inhibitors; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Terpenes	2006
Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 2006, Volume: 67, Issue:23 Topics: Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hypericum; Molecular Structure; Phloroglucinol; Terpenes	2006
Anti-staphylococcal acylphloroglucinols from Hypericum beanii. Phytochemistry, 2006, Volume: 67, Issue:23 Topics: Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol; Staphylococcus aureus; Structure-Activity Relationship	2006
Acylphloroglucinol derivatives from Hypericum prolificum. Journal of natural products, 2006, Volume: 69, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Pennsylvania; Phloroglucinol; Plants, Medicinal	2006
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort. Current drug metabolism, 2007, Volume: 8, Issue:2 Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes	2007
Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum. Phytochemistry, 2007, Volume: 68, Issue:7 Topics: Amino Acids; Bridged Bicyclo Compounds; Carbon Isotopes; Cells, Cultured; Chromatography, High Pressure Liquid; Hypericum; Isoleucine; Leucine; Molecular Structure; Phloroglucinol; Plant Shoots; Tandem Mass Spectrometry; Terpenes; Threonine; Valine	2007
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? Free radical research, 2007, Volume: 41, Issue:2 Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins	2007
Hyperforin accumulates in the translucent glands of Hypericum perforatum. Annals of botany, 2007, Volume: 99, Issue:6 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Molecular Structure; Phloroglucinol; Plant Leaves; Plants, Medicinal; Spectrophotometry, Ultraviolet; Terpenes	2007
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:5 Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes	2007
Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake. European journal of pharmacology, 2007, Aug-27, Volume: 569, Issue:3 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hypericum; Male; Mice; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Serotonin; Swimming; Triterpenes	2007
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort. Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:6 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Tablets; Terpenes; Transcription Factors; Transfection; Tumor Cells, Cultured	2007
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens. Journal of agricultural and food chemistry, 2007, Jul-25, Volume: 55, Issue:15 Topics: Acetates; Agrobacterium tumefaciens; Anthracenes; Bridged Bicyclo Compounds; Cyclopentanes; Hypericum; Oxylipins; Perylene; Phloroglucinol; Polyethylene Glycols; Seeds; Sucrose; Terpenes	2007
Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures. Phytochemistry, 2007, Volume: 68, Issue:21 Topics: Bridged Bicyclo Compounds; Cells, Cultured; Gas Chromatography-Mass Spectrometry; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Terpenes; Tissue Culture Techniques	2007
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:14 Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cell Line; Depression; Gene Expression Regulation; Humans; Hypericum; PC12 Cells; Phloroglucinol; Plant Extracts; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Terpenes; TRPC Cation Channels	2007
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. Journal of agricultural and food chemistry, 2007, Sep-05, Volume: 55, Issue:18 Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Dinoprostone; Flavonoids; Hypericum; Light; Macrophages; Mice; Perylene; Phloroglucinol; Plant Extracts; Terpenes	2007
Herpes virus inhibitory substances from Hypericum connatum Lam., a plant used in southern Brazil to treat oral lesions. Journal of ethnopharmacology, 2007, Sep-25, Volume: 113, Issue:3 Topics: Animals; Antiviral Agents; Brazil; Chlorocebus aethiops; Flavonoids; Hypericum; Medicine, Traditional; Mouth Diseases; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Simplexvirus; Vero Cells	2007
Variation of hyperforin in Hypericum montbretii during its phenological cycle. Natural product research, 2007, Volume: 21, Issue:13 Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flowers; Hypericum; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Terpenes	2007
Effect of hyperforin-enriched extract on pro-ejaculatory effect of 8-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats. Urology, 2007, Volume: 70, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bridged Bicyclo Compounds; Ejaculation; Electromyography; Hypericum; Male; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Terpenes	2007
Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Journal of natural products, 2007, Volume: 70, Issue:11 Topics: Anti-Bacterial Agents; Benzophenones; Benzoquinones; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Drugs, Chinese Herbal; Hypericum; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Conformation; Molecular Structure; Norfloxacin; Phloroglucinol; Plants, Medicinal; Staphylococcus aureus	2007
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. The international journal of biochemistry & cell biology, 2008, Volume: 40, Issue:8 Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Humans; Hypericum; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Male; NF-kappa B; Nitric Oxide Synthase Type II; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; Terpenes; Tumor Necrosis Factor-alpha	2008
Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum. Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10 Topics: Animals; Antifungal Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Hypericum; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Phloroglucinol; Stereoisomerism; Trichophyton	2008
Characterizing the metabolic fingerprint and anti-inflammatory activity of Hypericum gentianoides. Journal of agricultural and food chemistry, 2008, Jun-25, Volume: 56, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, High Pressure Liquid; Dinoprostone; Hypericum; Macrophages; Methanol; Mice; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization	2008
Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum. Journal of natural products, 2008, Volume: 71, Issue:6 Topics: Algorithms; Antioxidants; DNA Damage; Free Radical Scavengers; Hypericum; Molecular Structure; Phloroglucinol; Plants, Medicinal; Stereoisomerism; Taiwan; Xanthine Oxidase	2008
Cytotoxic effects of hyperatomarin, a prenylated phloroglucinol from Hypericum annulatum Moris subsp. annulatum, in a panel of malignant cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:11 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypericum; Inhibitory Concentration 50; Leukemia; Lymphoma; Phloroglucinol	2008
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines. Journal of agricultural and food chemistry, 2008, Jul-09, Volume: 56, Issue:13 Topics: Anthracenes; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Roots; Plants, Genetically Modified; Terpenes; Transformation, Genetic	2008
Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron. Phytochemistry, 2008, Volume: 69, Issue:11 Topics: Cell Line, Tumor; Cell Survival; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Structure-Activity Relationship	2008
Prenylated Phloroglucinol Derivatives from Hypericum perforatum var. angustifolium. Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:8 Topics: Hypericum; Phloroglucinol; Prenylation	2008
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages. Journal of integrative plant biology, 2008, Volume: 50, Issue:5 Topics: Bridged Bicyclo Compounds; Climate; Geography; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Plant Stems; Plant Structures; Population Dynamics; Seasons; Terpenes; Turkey	2008
The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009, Mar-02, Volume: 36, Issue:4-5 Topics: Adult; Biliary Tract; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Finasteride; Half-Life; Humans; Hypericum; Male; Phloroglucinol; Reference Values; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Terpenes	2009
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin. Behavioural brain research, 2009, May-16, Volume: 199, Issue:2 Topics: Animals; Anthracenes; Apoptosis; Bridged Bicyclo Compounds; DNA Fragmentation; Drugs, Chinese Herbal; Hypericum; Inhibition, Psychological; Male; Mice; Perylene; Phloroglucinol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Reflex, Acoustic; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Terpenes	2009
Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in rats. Journal of ethnopharmacology, 2009, Apr-21, Volume: 122, Issue:3 Topics: Amnesia; Animals; Apoptosis; Bridged Bicyclo Compounds; Central Nervous System Agents; Cerebral Cortex; Cholinergic Antagonists; DNA Fragmentation; Hypericum; Male; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Reflex, Startle; Scopolamine; Sensory Gating; Terpenes	2009
Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. British journal of clinical pharmacology, 2009, Volume: 67, Issue:2 Topics: Anthracenes; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Female; Haplotypes; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Preparations; Pregnane X Receptor; Receptors, Steroid; Terpenes; Young Adult	2009
Bioactive acylphloroglucinols from Hypericum densiflorum. Phytotherapy research : PTR, 2009, Volume: 23, Issue:12 Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibitors; Humans; Hypericum; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol	2009
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:16 Topics: Animals; Arachidonate 5-Lipoxygenase; Binding Sites; Bridged Bicyclo Compounds; Carrageenan; Cells, Cultured; Diglycerides; Humans; Hypericum; Leukotriene B4; Lipoxygenase Inhibitors; Male; MAP Kinase Signaling System; Microfilament Proteins; Neutrophils; Oxidation-Reduction; Phloroglucinol; Phospholipids; Pleurisy; Protein Structure, Tertiary; Protein Transport; Rats; Rats, Wistar; Terpenes; Tryptophan	2009
Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum. Fitoterapia, 2010, Volume: 81, Issue:2 Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Flavonoids; Flowers; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Reference Standards; Species Specificity; Terpenes	2010
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species. Natural product research, 2009, Volume: 23, Issue:13 Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey	2009
Petiolins F-I, benzophenone rhamnosides from Hypericum pseudopetiolatum var. kiusianum. Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:10 Topics: Benzophenones; Hypericum; Magnetic Resonance Spectroscopy; Molecular Conformation; Phloroglucinol	2009
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1 Topics: Adult; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds; Cell Line; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Gene Expression; Hepatocytes; Humans; Hypericum; Macaca fascicularis; Macaca mulatta; Male; Midazolam; Middle Aged; Models, Animal; Molecular Sequence Data; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Rifampin; Sequence Homology, Amino Acid; Terpenes; Transcriptional Activation; Transfection; Xenobiotics	2010
Supercritical fluid extraction and high performance liquid chromatographic determination of benzopyrans and phloroglucinol derivative in Hypericum polyanthemum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Jan-01, Volume: 878, Issue:1 Topics: Analysis of Variance; Benzopyrans; Carbon Dioxide; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Hexanes; Hypericum; Phloroglucinol; Plant Components, Aerial; Pressure; Reproducibility of Results; Sensitivity and Specificity; Temperature	2010
Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides. Chemistry & biodiversity, 2010, Volume: 7, Issue:1 Topics: Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Glucosides; Hep G2 Cells; HL-60 Cells; Humans; Hypericum; K562 Cells; Molecular Conformation; Phloroglucinol	2010
Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum Thunb. Phytotherapy research : PTR, 2010, Volume: 24, Issue:6 Topics: Antimalarials; Cell Line, Tumor; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Parasitic Sensitivity Tests; Phloroglucinol; Plant Extracts; Plasmodium falciparum	2010
Polyprenylated benzoylphloroglucinol-type derivatives including novel cage compounds from Hypericum erectum. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:3 Topics: Corynebacterium; Cyclization; Hemiterpenes; Hypericum; Leucine; Molecular Conformation; Pentanoic Acids; Phloroglucinol; Stereoisomerism	2010
Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:6 Topics: Animals; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Flow Cytometry; Hypericum; Macrophages; Mice; Microglia; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Synthase Type II; Phagocytosis; Phloroglucinol; Plant Extracts; Terpenes	2010
Biomimetic synthesis of polycyclic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum. Organic letters, 2010, Aug-06, Volume: 12, Issue:15 Topics: Biological Products; Cyclization; Hypericum; Molecular Structure; Oxidation-Reduction; Phloroglucinol; Polycyclic Aromatic Hydrocarbons	2010
Petiolins J-M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Topics: Anti-Bacterial Agents; Cell Line; Crystallography, X-Ray; Humans; Hypericum; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Conformation; Phloroglucinol; Prenylation	2010
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance. Natural product communications, 2010, Volume: 5, Issue:6 Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes	2010
Pharmacological studies on Hypericum perforatum fractions and constituents. Pharmaceutical biology, 2011, Volume: 49, Issue:1 Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypericum; In Vitro Techniques; Male; Perylene; Phloroglucinol; Phosphodiesterase Inhibitors; Plant Extracts; Quercetin; Rabbits; Terpenes; Verapamil	2011
Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. Journal of natural products, 2010, Nov-29, Volume: 73, Issue:11 Topics: Animals; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Drugs, Chinese Herbal; Hypericum; Lignans; Mice; Microbial Sensitivity Tests; Molecular Structure; Multidrug Resistance-Associated Proteins; Norfloxacin; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plant Leaves; Staphylococcus aureus; Tetracycline; Xanthones	2010
Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Feb-14, Volume: 42, Issue:3 Topics: Bridged Bicyclo Compounds; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hypericum; Microsomes, Liver; Phloroglucinol; Tandem Mass Spectrometry; Terpenes	2011
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Mar-01, Volume: 879, Issue:7-8 Topics: Anthracenes; Bridged Bicyclo Compounds; Chemical Fractionation; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flavonols; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Phloroglucinol; Plant Extracts; Terpenes	2011
Acylphloroglucinol and xanthones from Hypericum ellipticum. Phytochemistry, 2011, Volume: 72, Issue:7 Topics: Cell Line, Tumor; Humans; Hypericum; Inhibitory Concentration 50; Phloroglucinol; Xanthones	2011
Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chemico-biological interactions, 2011, Apr-25, Volume: 190, Issue:2-3 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cyclin-Dependent Kinase Inhibitor p27; Cytochromes c; DNA Fragmentation; G1 Phase; Humans; Hypericum; K562 Cells; Mitochondria; Phloroglucinol; Signal Transduction; Terpenes; Tumor Suppressor Protein p53	2011
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. Phytochemistry, 2011, Volume: 72, Issue:14-15 Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes	2011
Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Animals; Antifungal Agents; Antineoplastic Agents; Aspergillus niger; Candida albicans; Cell Line, Tumor; Cryptococcus neoformans; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypericum; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Phloroglucinol; Stereoisomerism; Structure-Activity Relationship; Trichophyton	2011
Antibacterial acylphloroglucinols from Hypericum olympicum. Journal of natural products, 2012, Mar-23, Volume: 75, Issue:3 Topics: Anti-Bacterial Agents; Hypericum; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol; Staphylococcus aureus	2012
Spirocyclic acylphloroglucinol derivatives from Hypericum beanii. Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hypericum; Molecular Structure; Phloroglucinol; Phytotherapy; Plant Extracts; Stereoisomerism	2011
Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum: quantification and mathematical modeling. Journal of separation science, 2011, Volume: 34, Issue:21 Topics: Benzophenones; Chromatography, High Pressure Liquid; Hypericum; Models, Chemical; Phloroglucinol; Plant Components, Aerial; Plant Extracts	2011
Prenylated acylphloroglucinols, chipericumins A-D, from Hypericum chinense. Journal of natural products, 2012, Mar-23, Volume: 75, Issue:3 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Aspergillus niger; Bacillus subtilis; Candida albicans; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Escherichia coli; Humans; Hypericum; Mice; Microbial Sensitivity Tests; Micrococcus; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plant Roots; Prenylation; Spiro Compounds; Staphylococcus aureus; Trichophyton	2012
Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs. Behavioural brain research, 2012, Mar-01, Volume: 228, Issue:1 Topics: Animals; Antidepressive Agents; Benzazepines; Biogenic Monoamines; Bupropion; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fenclonine; Fluoxetine; Hypericum; Imipramine; Immobility Response, Tonic; Locomotion; Male; Mice; Mice, Inbred Strains; Phloroglucinol; Plant Extracts; Prazosin; Rats; Rats, Wistar; Receptors, Catecholamine; Sulpiride; Vesicular Monoamine Transport Proteins; Yohimbine	2012
Inhibition of bacterial growth and biofilm production by constituents from Hypericum spp. Phytotherapy research : PTR, 2012, Volume: 26, Issue:7 Topics: Anti-Bacterial Agents; Biofilms; Gram-Positive Bacteria; Hypericum; Microbial Sensitivity Tests; Phloroglucinol	2012
Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics. Planta medica, 2012, Volume: 78, Issue:5 Topics: Chromatography, High Pressure Liquid; Hypericum; Mass Spectrometry; Metabolome; Molecular Structure; Phloroglucinol; Plant Extracts; Plant Preparations; Principal Component Analysis; Quality Control; Terpenes	2012
Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells. Phytochemistry, 2012, Volume: 77 Topics: Angiogenesis Inhibitors; Cell Line; Cell Proliferation; Chemical Fractionation; Chromatography, High Pressure Liquid; Endothelial Cells; Humans; Hypericum; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2012
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria. Phytotherapy research : PTR, 2012, Volume: 26, Issue:9 Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes	2012
Synthesis of uliginosins A and B. Natural product communications, 2012, Volume: 7, Issue:2 Topics: Hypericum; Molecular Structure; Phloroglucinol	2012
Three new phloroglucinol derivatives from Hypericum scabrum. Journal of Asian natural products research, 2012, Volume: 14, Issue:5 Topics: Drugs, Chinese Herbal; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2012
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. TheScientificWorldJournal, 2012, Volume: 2012 Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Plant Leaves; Plant Stems; Terpenes; Turkey	2012
Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai. Natural product research, 2013, Volume: 27, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Hypericum; Mice; Molecular Structure; Phloroglucinol; Plants, Medicinal	2013
Polycyclic polyprenylated acylphloroglucinols and cytotoxic constituents of Hypericum androsaemum. Chemistry & biodiversity, 2012, Volume: 9, Issue:6 Topics: Cell Line, Tumor; Cell Survival; HL-60 Cells; Humans; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Phloroglucinol; Polycyclic Compounds	2012
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. Hippocampus, 2013, Volume: 23, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Dendritic Spines; Depression; Gene Expression; Hippocampus; Hypericum; Lanthanum; Organ Culture Techniques; Phloroglucinol; Plant Extracts; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Terpenes; Transfection; TRPC Cation Channels	2013
Prenylated phloroglucinol derivatives from Hypericum sampsonii. Fitoterapia, 2012, Volume: 83, Issue:8 Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Hypericum; Macrophages; Models, Molecular; Molecular Structure; Phloroglucinol; Plant Leaves; Plant Stems	2012
Bi-, tri-, and polycyclic acylphloroglucinols from Hypericum empetrifolium. Journal of natural products, 2012, Oct-26, Volume: 75, Issue:10 Topics: Endothelial Cells; Greece; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2012
Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds. Parasitology international, 2013, Volume: 62, Issue:2 Topics: Animals; Antiprotozoal Agents; Benzopyrans; Cell Membrane; Cell Survival; Chlorocebus aethiops; Chromatography, Supercritical Fluid; Hypericum; L-Lactate Dehydrogenase; Metronidazole; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Protozoan Proteins; Trichomonas vaginalis; Vero Cells	2013
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:12 Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Hypericum; Hypoxia; Ischemia; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Perylene; Phloroglucinol; Plant Extracts; Potassium Chloride; Rats; Rats, Sprague-Dawley; Terpenes; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Overactive	2012
Investigation of the antioxidant properties of hyperjovinol A through its Cu(II) coordination ability. Journal of molecular modeling, 2013, Volume: 19, Issue:5 Topics: Antioxidants; Computer Simulation; Coordination Complexes; Copper; Electrons; Free Radicals; Hypericum; Models, Chemical; Oxidation-Reduction; Phloroglucinol; Quantum Theory; Thermodynamics	2013
Identification and biosynthesis of acylphloroglucinols in Hypericum gentianoides. Physiologia plantarum, 2013, Volume: 148, Issue:3 Topics: Biosynthetic Pathways; Chromatography, Liquid; Ecotype; Hypericum; Ions; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization	2013
Downregulation of β1 -adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John's wort. The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:6 Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclic AMP; Down-Regulation; Glioblastoma; Hypericum; Phloroglucinol; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Terpenes	2013
Antiproliferative activity of the dimeric phloroglucinol and benzophenone derivatives of Hypericum spp. native to southern Brazil. Anti-cancer drugs, 2013, Volume: 24, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Benzophenones; Brazil; Cell Proliferation; HT29 Cells; Humans; Hypericum; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Protein Multimerization	2013
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein. Brain pathology (Zurich, Switzerland), 2014, Volume: 24, Issue:1 Topics: Alzheimer Disease; Amyloid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Hypericum; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phloroglucinol; Plant Extracts; Terpenes	2014
Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens. Journal of natural products, 2013, Sep-27, Volume: 76, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; HL-60 Cells; Humans; Hypericum; Inhibitory Concentration 50; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2013
Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production. Journal of natural products, 2013, Sep-27, Volume: 76, Issue:9 Topics: Biofilms; Enterococcus faecalis; Hypericum; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phloroglucinol; Staphylococcus aureus; Terpenes	2013
Hyperforin inhibits cell proliferation and differentiation in mouse embryonic stem cells. Cell proliferation, 2013, Volume: 46, Issue:5 Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Embryonic Stem Cells; Hypericum; Mice; NIH 3T3 Cells; Phloroglucinol; Psychotropic Drugs; Terpenes	2013
Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained from Hypericum caprifoliatum. Pharmaceutical biology, 2014, Volume: 52, Issue:1 Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Hippocampus; Hypericum; Male; Mice; Phloroglucinol; Plant Extracts; Sodium; Sodium-Potassium-Exchanging ATPase; Swimming; Veratrine	2014
St. John's wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity. Acta diabetologica, 2014, Volume: 51, Issue:1 Topics: Animals; Cells, Cultured; Cytokines; Cytoprotection; Drug Evaluation, Preclinical; Glucose; Humans; Hypericum; Insulin; Insulin Secretion; Islets of Langerhans; Male; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; Terpenes	2014
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. Fitoterapia, 2014, Volume: 92 Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes	2014
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice. Current Alzheimer research, 2013, Volume: 10, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypericum; Maze Learning; Mice; Mice, Transgenic; Microglia; Multidrug Resistance-Associated Proteins; Peptide Fragments; Phagocytes; Phloroglucinol; Phytotherapy; Plant Preparations; Plaque, Amyloid; Terpenes; Time Factors	2013
Modulation of oxidative stress and Ca(2+) mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum. Neuroscience, 2014, Mar-28, Volume: 263 Topics: Animals; Calcium; Cell Survival; Ganglia, Spinal; Hypericum; Male; Neurons; Oxidative Stress; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Terpenes; TRPM Cation Channels	2014
Cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum attenuatum. Fitoterapia, 2014, Volume: 95 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Hypericum; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plant Extracts	2014
New acylphloroglucinol derivatives with diverse architectures from Hypericum henryi. Organic letters, 2014, May-02, Volume: 16, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cholinesterase Inhibitors; HL-60 Cells; Humans; Hypericum; Molecular Structure; Phloroglucinol; Polycyclic Compounds; X-Ray Diffraction	2014
Two new polyprenylated acylphloroglucinols from Hypericum scabrum. Journal of Asian natural products research, 2014, Volume: 16, Issue:7 Topics: Drugs, Chinese Herbal; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Stereoisomerism	2014
Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice. The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:12 Topics: Analgesics; Animals; Behavior, Animal; Biogenic Monoamines; Glutamic Acid; Hypericum; Male; Mice, Inbred Strains; Pain; Pain Measurement; Pain Threshold; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Synaptic Transmission	2014
Synthesis of natural-like acylphloroglucinols with anti-proliferative, anti-oxidative and tube-formation inhibitory activity. European journal of medicinal chemistry, 2014, Oct-06, Volume: 85 Topics: Antioxidants; Biomimetic Materials; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Endothelial Cells; Humans; Hypericum; Phloroglucinol; Structure-Activity Relationship	2014
Hyperuralones A and B, new acylphloroglucinol derivatives with intricately caged cores from Hypericum uralum. Organic letters, 2014, Sep-19, Volume: 16, Issue:18 Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2014
Spirocyclic acylphloroglucinol derivatives from Hypericum pyramidatum. Natural product communications, 2014, Volume: 9, Issue:7 Topics: Hypericum; Molecular Structure; Phloroglucinol	2014
Acylphloroglucinol derivatives from Hypericum andinum: antidepressant-like activity of andinin A. Journal of natural products, 2014, Oct-24, Volume: 77, Issue:10 Topics: Administration, Oral; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Hypericum; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peru; Phloroglucinol	2014
Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Oct-15, Volume: 21, Issue:12 Topics: Amitriptyline; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hypericum; Male; Mice; Morphine; Pain; Phloroglucinol; Plant Components, Aerial	2014
Bioactive acylphloroglucinols with adamantyl skeleton from Hypericum sampsonii. Organic letters, 2014, Dec-19, Volume: 16, Issue:24 Topics: Adamantane; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Hypericum; Molecular Structure; Phloroglucinol; Polycyclic Compounds	2014
Novel polyprenylated phloroglucinols from Hypericum sampsonii. Molecules (Basel, Switzerland), 2014, Nov-28, Volume: 19, Issue:12 Topics: Carbon-13 Magnetic Resonance Spectroscopy; Hypericum; Phloroglucinol; Prenylation; Proton Magnetic Resonance Spectroscopy	2014
Dioxasampsones A and B, two polycyclic polyprenylated acylphloroglucinols with unusual epoxy-ring-fused skeleton from Hypericum sampsonii. Organic letters, 2014, Dec-19, Volume: 16, Issue:24 Topics: Epoxy Compounds; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; X-Ray Diffraction	2014
Protonophore properties of hyperforin are essential for its pharmacological activity. Scientific reports, 2014, Dec-16, Volume: 4 Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Chromaffin Cells; HEK293 Cells; Humans; Hypericum; Lipid Bilayers; Mice; Mice, Knockout; Microglia; Phloroglucinol; Plant Extracts; Protons; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel	2014
DNA-protective activities of hyperforin and aristoforin. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:3 Topics: Antioxidants; DNA; DNA Breaks; Free Radical Scavengers; Hypericum; Iron; Iron Chelating Agents; Phloroglucinol; Terpenes; Topoisomerase I Inhibitors	2015
Hypersubones A and B, new polycyclic acylphloroglucinols with intriguing adamantane type cores from Hypericum subsessile. Organic letters, 2015, Mar-06, Volume: 17, Issue:5 Topics: Adamantane; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; X-Ray Diffraction	2015
Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn. Phytochemistry, 2015, Volume: 115 Topics: Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; HIV-1; HL-60 Cells; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Spiro Compounds	2015
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress. Phytotherapy research : PTR, 2015, Volume: 29, Issue:7 Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha	2015
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi. Journal of natural products, 2015, Apr-24, Volume: 78, Issue:4 Topics: Acetylcholinesterase; Humans; Hypericum; Ketones; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Terpenes	2015
Hypermongones A-J, Rare Methylated Polycyclic Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum. Journal of natural products, 2015, May-22, Volume: 78, Issue:5 Topics: Animals; Drugs, Chinese Herbal; Flowers; HL-60 Cells; Humans; Hypericum; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; X-Ray Diffraction	2015
Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice. Journal of natural products, 2015, Aug-28, Volume: 78, Issue:8 Topics: Alzheimer Disease; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Hippocampus; Hypericum; Mice; Microsomes, Liver; Molecular Structure; Phloroglucinol; Terpenes	2015
Isolation and anticancer, anthelminthic, and antiviral (HIV) activity of acylphloroglucinols, and regioselective synthesis of empetrifranzinans from Hypericum roeperianum. Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19 Topics: Animals; Anthelmintics; Antineoplastic Agents, Phytogenic; Antiviral Agents; Caenorhabditis elegans; Cell Line; Cell Proliferation; Chromans; HIV-1; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Conformation; Phloroglucinol; Plant Leaves; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism; Xanthenes	2015
Polyprenylated Phloroglucinols from Hypericum maculatum. Natural product communications, 2015, Volume: 10, Issue:7 Topics: Drug Screening Assays, Antitumor; Humans; Hypericum; K562 Cells; Phloroglucinol	2015
Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii. Scientific reports, 2015, Oct-06, Volume: 5 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Benzofurans; Cell Line, Tumor; Circular Dichroism; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Hypericum; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Quinones	2015
1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum. Journal of natural products, 2015, Dec-24, Volume: 78, Issue:12 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2015
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells. Life sciences, 2016, Jan-01, Volume: 144 Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; RNA, Neoplasm; Terpenes; Tetrazolium Salts; Thiazoles	2016
St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells. Journal of immunotoxicology, 2016, Volume: 13, Issue:3 Topics: Animals; Cell Proliferation; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Hypericum; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Phloroglucinol; Phytotherapy; Spleen; T-Lymphocytes, Regulatory; Terpenes	2016
Prenylated Acylphloroglucinols with Leishmanicidal Activity from the Fern Elaphoglossum lindbergii. Journal of natural products, 2016, Jan-22, Volume: 79, Issue:1 Topics: Ferns; Hypericum; Leishmania; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol; Prenylation	2016
Dimeric acylphloroglucinols from Hypericum austrobrasiliense exhibiting antinociceptive activity in mice. Phytochemistry, 2016, Volume: 122 Topics: Analgesics; Animals; Brazil; Hypericum; Male; Mice; Molecular Structure; Motor Activity; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol	2016
Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging. Physiologia plantarum, 2016, Volume: 157, Issue:1 Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes	2016
Hyperforin production in Hypericum perforatum root cultures. Journal of biotechnology, 2016, Mar-20, Volume: 222 Topics: Bioreactors; Hypericum; Phloroglucinol; Plant Extracts; Plant Roots; Terpenes	2016
Prenylated phenyl polyketides and acylphloroglucinols from Hypericum peplidifolium. Phytochemistry, 2016, Volume: 124 Topics: Antineoplastic Agents, Phytogenic; Antiviral Agents; Herpesvirus 1, Human; Hypericum; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Polyketides; Prenylation	2016
Tricyclic Acylphloroglucinols from Hypericum lanceolatum and Regioselective Synthesis of Selancins A and B. Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Cameroon; HT29 Cells; Humans; Hypericum; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Stereoisomerism; Terpenes	2016
Two new prenylated phloroglucinol derivatives from Hypericum scabrum. Journal of Asian natural products research, 2016, Volume: 18, Issue:5 Topics: Drugs, Chinese Herbal; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Prenylation; Stereoisomerism	2016
Hyperjapones A-E, Terpenoid Polymethylated Acylphloroglucinols from Hypericum japonicum. Organic letters, 2016, Apr-15, Volume: 18, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Benzoates; Cell Line, Tumor; Cellulose; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plant Extracts; Polyketides; Terpenes; X-Ray Diffraction	2016
(±)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum. Journal of natural products, 2016, 05-27, Volume: 79, Issue:5 Topics: Antiviral Agents; Crystallography, X-Ray; Drugs, Chinese Herbal; Herpesvirus 8, Human; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Stereoisomerism	2016
Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A. Journal of natural products, 2016, 05-27, Volume: 79, Issue:5 Topics: Administration, Oral; Animals; Antidepressive Agents; Drugs, Chinese Herbal; Humans; Hypericum; Mice; Molecular Structure; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Phloroglucinol; Rats	2016
Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum. Journal of natural products, 2016, 06-24, Volume: 79, Issue:6 Topics: Drugs, Chinese Herbal; Hep G2 Cells; HL-60 Cells; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plant Components, Aerial	2016
Yezo'otogirins D-H, Acylphloroglucinols and Meroterpenes from Hypericum yezoense. Chemical & pharmaceutical bulletin, 2016, Volume: 64, Issue:7 Topics: Dose-Response Relationship, Drug; Escherichia coli; Hypericum; Microbial Sensitivity Tests; Molecular Conformation; Phloroglucinol; Plant Extracts; Staphylococcus aureus; Structure-Activity Relationship	2016
Erecricins A-E, prenylated acylphloroglucinols from the roots of Hypericum erectum. Fitoterapia, 2016, Volume: 114 Topics: Anti-Bacterial Agents; Bacteria; Hypericum; Microbial Sensitivity Tests; Molecular Structure; Phloroglucinol; Plant Roots; Prenylation	2016
Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum. Fitoterapia, 2016, Volume: 115 Topics: Acetaminophen; Hemiterpenes; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Hypericum; Molecular Structure; Phloroglucinol; Plant Components, Aerial; Protective Agents	2016
St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells. The international journal of biochemistry & cell biology, 2016, Volume: 81, Issue:Pt A Topics: Animals; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cytokines; DNA; Enzyme Activation; Hypericum; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Phloroglucinol; Phosphorylation; Plant Extracts; Rats; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Terpenes; Transcriptional Activation	2016
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. Mycorrhiza, 2017, Volume: 27, Issue:4 Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes	2017
Skeleton Reassignment of Type C Polycyclic Polyprenylated Acylphloroglucinols. Journal of natural products, 2017, 01-27, Volume: 80, Issue:1 Topics: Clusiaceae; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Polycyclic Compounds	2017
The anti-Trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol B modulates extracellular nucleotide hydrolysis. Chemical biology & drug design, 2017, Volume: 90, Issue:5 Topics: Antiparasitic Agents; Cell Line; Female; Humans; Hydrolysis; Hypericum; Nucleotides; Phloroglucinol; Trichomonas vaginalis; Trichomonas Vaginitis	2017
Modulation of anthraquinones and phloroglucinols biosynthesis in Hypericum spp. by cryogenic treatment. Journal of biotechnology, 2017, Jun-10, Volume: 251 Topics: Anthraquinones; Cryopreservation; Freezing; Hypericum; Phloroglucinol; Plant Shoots	2017
Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum. Journal of natural products, 2017, 05-26, Volume: 80, Issue:5 Topics: Acetylcholinesterase; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Circular Dichroism; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; X-Ray Diffraction	2017
Denudatin A, a Dimeric Acylphloroglucinol from Hypericum denudatum Presents an Antinociceptive Effect in Mice. Planta medica, 2017, Volume: 83, Issue:17 Topics: Analgesics; Animals; Hypericum; Male; Mice; Phloroglucinol; Plant Extracts	2017
Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum. Fitoterapia, 2017, Volume: 120 Topics: Animals; Antioxidants; Chlorocebus aethiops; Glycoside Hydrolase Inhibitors; Hypericum; Italy; Phloroglucinol; Phytochemicals; Plant Components, Aerial; Plant Extracts; Quercetin; Vero Cells	2017
Downstream processing of hyperforin from Hypericum perforatum root cultures. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 126 Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Hypericum; Phloroglucinol; Plant Extracts; Plant Roots; Terpenes	2018
Polyprenylated acylphloroglucinols from Hypericum scabrum. Phytochemistry, 2017, Volume: 142 Topics: Animals; Antidepressive Agents; Brain; Cyclohexanones; Drugs, Chinese Herbal; Heterocyclic Compounds, Bridged-Ring; HL-60 Cells; Humans; Hypericum; Liver; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Plant Components, Aerial; Rats; Serotonin Antagonists	2017
Polycyclic phloroglucinols as PTP1B inhibitors from Hypericum longistylum: Structures, PTP1B inhibitory activities, and interactions with PTP1B. Bioorganic chemistry, 2017, Volume: 75 Topics: Binding Sites; Catalytic Domain; Circular Dichroism; Enzyme Inhibitors; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Docking Simulation; Phloroglucinol; Plant Extracts; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Thermodynamics	2017
Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum. Bioorganic & medicinal chemistry letters, 2017, 11-01, Volume: 27, Issue:21 Topics: Acetaminophen; Cell Survival; Circular Dichroism; Hep G2 Cells; Humans; Hypericum; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Conformation; Phloroglucinol; Plant Components, Aerial; Protective Agents	2017
New phloroglucinol derivatives from the whole plant of Hypericum uralum. Fitoterapia, 2017, Volume: 123 Topics: Antineoplastic Agents, Phytogenic; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hypericum; MCF-7 Cells; Molecular Structure; Phloroglucinol	2017
Persistence of STAT-1 inhibition and induction of cytokine resistance in pancreatic β cells treated with St John's wort and its component hyperforin. The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:1 Topics: Animals; Apoptosis; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Hypericum; Insulin-Secreting Cells; Phloroglucinol; Plant Extracts; Rats; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor; Terpenes; Time Factors	2019
Hyperattenins L and M, two new polyprenylated acylphloroglucinols with adamantyl and homoadamantyl core structures from Hypericum attenuatum. Fitoterapia, 2018, Volume: 125 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; China; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plant Components, Aerial	2018
Phloroglucinol derivatives from Hypericum species trigger mitochondrial dysfunction in Leishmania amazonensis. Parasitology, 2018, Volume: 145, Issue:9 Topics: Antiprotozoal Agents; Cells, Cultured; Erythrocytes; Humans; Hypericum; Inhibitory Concentration 50; Leishmania; Life Cycle Stages; Macrophages; Mitochondria; Oxidative Stress; Phloroglucinol; Plant Extracts; Reactive Oxygen Species	2018
Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress. Planta medica, 2018, Volume: 84, Issue:9-10 Topics: Biomarkers; Cell Line; Dexamethasone; Gene Expression Regulation; Glucosides; Humans; Hypericum; Neurons; Phloroglucinol; Quercetin; Stress, Physiological; Terpenes	2018
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication. PloS one, 2018, Volume: 13, Issue:3 Topics: Anti-HIV Agents; Endemic Diseases; HIV Reverse Transcriptase; HIV-1; Hypericum; Phenotype; Phloroglucinol; Prenylation; Spain; Virus Replication	2018
Methodological aspects of biologically active compounds quantification in the genus Hypericum. Journal of pharmaceutical and biomedical analysis, 2018, Jun-05, Volume: 155 Topics: Anthracenes; Catechin; Chlorogenic Acid; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Quercetin; Rutin; Terpenes	2018
Cytotoxic prenylated acylphloroglucinols from Hypericum annulatum. Fitoterapia, 2018, Volume: 127 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Hypericum; Molecular Structure; Phloroglucinol; Prenylation	2018
Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum. Journal of natural products, 2018, 04-27, Volume: 81, Issue:4 Topics: Anti-Bacterial Agents; Hypericum; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Phloroglucinol; X-Ray Diffraction	2018
Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum. Organic & biomolecular chemistry, 2018, 06-06, Volume: 16, Issue:22 Topics: Animals; Cell Line, Tumor; Hemiterpenes; Heterocyclic Compounds, 3-Ring; Hypericum; Models, Chemical; Neuroprotective Agents; Phloroglucinol; Plant Leaves; Rats; Stereoisomerism	2018
Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species. Chemistry & biodiversity, 2018, Volume: 15, Issue:11 Topics: Analgesics; Animals; Brazil; Dose-Response Relationship, Drug; Hypericum; Male; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Pain Measurement; Phloroglucinol; Plant Roots	2018
Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum. Organic & biomolecular chemistry, 2018, 11-07, Volume: 16, Issue:43 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Hypericum; Molecular Docking Simulation; Phloroglucinol; Polycyclic Compounds; Prenylation; Protein Conformation	2018
Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron. Journal of natural products, 2018, 11-26, Volume: 81, Issue:11 Topics: Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Humans; Hypericum; Methylation; Molecular Structure; Phloroglucinol; Polycyclic Aromatic Hydrocarbons; Prenylation; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization	2018
homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum. Fitoterapia, 2019, Volume: 133 Topics: Adamantane; Animals; Cell Line; Cell Line, Tumor; China; Humans; Hypericum; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Components, Aerial; Rats	2019
Hyperbeanols F-Q, diverse monoterpenoid polyprenylated acylphloroglucinols from the flowers of Hypericum beanii. Phytochemistry, 2019, Volume: 159 Topics: Animals; Anti-Inflammatory Agents; Flowers; Hypericum; Lipopolysaccharides; Mice; Molecular Structure; Monoterpenes; Nitric Oxide; Phloroglucinol; Prenylation; RAW 264.7 Cells; Spectrum Analysis; Stereoisomerism	2019
Polycyclic polyprenylated acylphloroglucinol and phenolic metabolites from the aerial parts of Hypericum elatoides and their neuroprotective and anti-neuroinflammatory activities. Phytochemistry, 2019, Volume: 159 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Crystallography, X-Ray; Hydrogen Peroxide; Hypericum; Inhibitory Concentration 50; Lipopolysaccharides; Microglia; Molecular Structure; Neuroprotective Agents; Nitric Oxide; PC12 Cells; Phenols; Phloroglucinol; Plant Components, Aerial; Polycyclic Compounds; Prenylation; Rats; Spectrum Analysis	2019
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Feb-15, Volume: 54 Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Membrane Fluidity; Perylene; Phloroglucinol; Phosphatidylethanolamines; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Signal Transduction; Terpenes	2019
Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort. Clinical pharmacokinetics, 2019, Volume: 58, Issue:7 Topics: Adult; Alprazolam; Antineoplastic Agents; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hypericum; Imatinib Mesylate; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Models, Biological; Phloroglucinol; Terpenes	2019
Hyperpatulols A-I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum. Bioorganic chemistry, 2019, Volume: 87 Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flowers; Humans; Hypericum; Molecular Structure; Phloroglucinol; Spiro Compounds; Structure-Activity Relationship; Vimentin	2019
Hyperascyrins L - N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron. Journal of Asian natural products research, 2019, Volume: 21, Issue:5 Topics: Acetaminophen; Analgesics; Cell Line; Glutamic Acid; Hepatocytes; Humans; Hypericum; Models, Molecular; Molecular Structure; Neuroprotective Agents; Phloroglucinol; Plant Components, Aerial	2019
Prenylated Acylphloroglucinols from Hypericum faberi. Journal of natural products, 2019, 05-24, Volume: 82, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Pancreatic Neoplasms; Phloroglucinol; Prenylation	2019
Hyperforatins L-U: Prenylated acylphloroglucinols with a terminal double bond from Hypericum perforatum L. (St John's Wort). Phytochemistry, 2019, Volume: 164 Topics: Acetylcholinesterase; Animals; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Corticosterone; Dose-Response Relationship, Drug; Hypericum; Molecular Conformation; Neuroprotective Agents; PC12 Cells; Phloroglucinol; Rats; Structure-Activity Relationship	2019
Polycyclic polyprenylated acylphloroglucinols from Natural product research, 2021, Volume: 35, Issue:2 Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
LC-MS Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174 Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Cell Line; Cell Survival; Chromatography, Liquid; Flavonoids; Humans; Hydroxybenzoates; Hypericum; Inflammation; Inhibitory Concentration 50; Mass Spectrometry; Nepal; NF-kappa B p50 Subunit; Phloroglucinol; Plant Extracts; THP-1 Cells; Transcription Factor AP-1; Xanthones	2019
Prenylated benzophenone derivatives from Hypericum patulum. Journal of natural medicines, 2020, Volume: 74, Issue:1 Topics: Benzophenones; Hypericum; Molecular Structure; Phloroglucinol; Plant Leaves; Prenylation; Stereoisomerism	2020
Hypascyrins A-E, Prenylated Acylphloroglucinols from Journal of natural products, 2019, 10-25, Volume: 82, Issue:10 Topics: Anti-Infective Agents; Bacillus subtilis; Hypericum; Methicillin-Resistant Staphylococcus aureus; Phenols; Phloroglucinol; Plant Roots; Prenylation	2019
Three new prenyloxy chromanones from aerial parts of Hypericum aucheri. Fitoterapia, 2019, Volume: 139 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Bulgaria; Caspase 9; Cell Line, Tumor; Chromones; Humans; Hypericum; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Components, Aerial; Prenylation	2019
Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora. Chemistry & biodiversity, 2020, Volume: 17, Issue:1 Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Sicily; Species Specificity; Terpenes	2020
Phloroglucinol derivatives from Natural product research, 2021, Volume: 35, Issue:22 Topics: Cell Proliferation; Humans; Hypericum; Phloroglucinol; Plant Extracts; Wound Healing	2021
Revision of the Structure of Hypatulone A by NMR, Computations, and Biosynthetic Considerations. Organic letters, 2020, 01-17, Volume: 22, Issue:2 Topics: Biological Products; Hypericum; Magnetic Resonance Spectroscopy; Molecular Conformation; Phloroglucinol; Quantum Theory	2020
Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles. Molecular pharmaceutics, 2020, 03-02, Volume: 17, Issue:3 Topics: Adult; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Biological Products; Blood Donors; Capsules; Cells, Cultured; Drug Delivery Systems; Healthy Volunteers; Humans; Hypericum; Lipoxygenase Inhibitors; Nanoparticles; Neutrophils; Phloroglucinol; Plant Extracts; Protein Binding; Serum Albumin, Human; Solubility; Terpenes; Water	2020
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca Journal of medicinal chemistry, 2020, 02-27, Volume: 63, Issue:4 Topics: Animals; Calcium Channel Agonists; Calcium Channels, T-Type; HEK293 Cells; Humans; Hypericum; Ion Channel Gating; Membrane Potentials; Mice; Monoterpenes; Mutation; Phloroglucinol	2020
Metabolomic fingerprinting and genetic discrimination of four Hypericum taxa from Greece. Phytochemistry, 2020, Volume: 174 Topics: Greece; Hypericum; Mass Spectrometry; Metabolomics; Phloroglucinol; Plant Extracts	2020
Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum. Fitoterapia, 2020, Volume: 142 Topics: Adamantane; Hep G2 Cells; Humans; Hypericum; Phloroglucinol; Polycyclic Compounds; Protective Agents	2020
Polycyclic polyprenylated acylphloroglucinols with acetylcholinesterase inhibitory activities from Hypericum perforatum. Fitoterapia, 2020, Volume: 143 Topics: China; Cholinesterase Inhibitors; Circular Dichroism; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Components, Aerial	2020
Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Journal of Asian natural products research, 2020, Volume: 22, Issue:6 Topics: Hep G2 Cells; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2020
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma. Environmental toxicology, 2020, Volume: 35, Issue:10 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Hypericum; Phloroglucinol; Signal Transduction; Terpenes; Transcription Factor RelA	2020
Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum. Fitoterapia, 2020, Volume: 146 Topics: China; Hypericum; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Components, Aerial; Protease Inhibitors; Ubiquitin-Specific Peptidase 7	2020
Two novel cyclohexanone-monocyclic polycyclic polyprenylated acylphloroglucinols from Natural product research, 2022, Volume: 36, Issue:2 Topics: Cyclohexanones; Fruit; Garcinia; Hypericum; Molecular Structure; Phloroglucinol	2022
Dimethylated acylphloroglucinol meroterpenoids with anti-oral-bacterial and anti-inflammatory activities from Hypericum elodeoides. Bioorganic chemistry, 2020, Volume: 104 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Fusobacterium nucleatum; Hypericum; Lipopolysaccharides; Mice; Microbial Sensitivity Tests; Molecular Structure; Nitric Oxide; Phloroglucinol; RAW 264.7 Cells; Streptococcus mutans; Streptococcus sanguis; Structure-Activity Relationship; Terpenes	2020
Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro. Journal of ethnopharmacology, 2021, Mar-01, Volume: 267 Topics: Animals; Chlorocebus aethiops; Coccidiostats; Cytokines; Hypericum; Inflammation Mediators; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Phloroglucinol; Plant Extracts; RAW 264.7 Cells; Terpenes; Toxoplasma; Toxoplasmosis, Cerebral; Vero Cells	2021
Two new seco-polycyclic polyprenylated acylphloroglucinol from Organic & biomolecular chemistry, 2021, 01-06, Volume: 19, Issue:1 Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Hypericum; MCF-7 Cells; Models, Molecular; Molecular Conformation; Phloroglucinol; Prenylation	2021
An Integrated LC-ESI-MS Molecules (Basel, Switzerland), 2020, Dec-15, Volume: 25, Issue:24 Topics: Chromatography, Liquid; Hypericum; Limit of Detection; Phloroglucinol; Spectrometry, Mass, Electrospray Ionization	2020
Nine prenylated acylphloroglucinols with potential anti-depressive and hepatoprotective activities from Hypericum scabrum. Bioorganic chemistry, 2021, Volume: 107 Topics: Animals; Antidepressive Agents; Cell Line; Hemiterpenes; Hypericum; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phloroglucinol; Plant Components, Aerial; Protective Agents; Rats; Synaptosomes	2021
Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα. Bioorganic chemistry, 2021, Volume: 107 Topics: Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Density Functional Theory; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypericum; Molecular Structure; Phloroglucinol; Retinoid X Receptor alpha; Structure-Activity Relationship	2021
Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Journal of agricultural and food chemistry, 2021, Jan-20, Volume: 69, Issue:2 Topics: Anti-Inflammatory Agents; Antioxidants; Flowers; Humans; Hypericum; Molecular Structure; Non-alcoholic Fatty Liver Disease; Phloroglucinol; Terpenes	2021
Two new polycyclic polyprenylated acylphloroglucinols derivatives from Journal of Asian natural products research, 2021, Volume: 23, Issue:11 Topics: Circular Dichroism; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell metabolism, 2021, 03-02, Volume: 33, Issue:3 Topics: Adipose Tissue, Brown; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Binding Sites; Cold Temperature; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Hypericum; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondrial Proteins; Molecular Docking Simulation; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phloroglucinol; Signal Transduction; Terpenes; Thermogenesis; Uncoupling Protein 1; Up-Regulation	2021
Hypseudohenrins I - K: three new polycyclic polyprenylated acylphloroglucinol derivatives from Journal of Asian natural products research, 2021, Volume: 23, Issue:6 Topics: Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
Hymoins A-D: Two Pairs of Polyprenylated Acylphloroglucinols from Organic letters, 2021, 04-16, Volume: 23, Issue:8 Topics: Animals; Circular Dichroism; Crystallography, X-Ray; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Rabbits	2021
Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don. Phytochemistry, 2021, Volume: 187 Topics: Circular Dichroism; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
Discovery of nor-bicyclic polyprenylated acylphloroglucinols possessing diverse architectures with anti-hepatoma activities from Hypericum patulum. Bioorganic chemistry, 2021, Volume: 111 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Density Functional Theory; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Hypericum; Models, Molecular; Molecular Structure; Phloroglucinol; Structure-Activity Relationship	2021
(±)-hyperzewalsins A-D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim. Phytochemistry, 2021, Volume: 187 Topics: Animals; Circular Dichroism; Hypericum; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Phloroglucinol	2021
Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi. Phytochemistry, 2021, Volume: 187 Topics: Anti-Inflammatory Agents; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii. Chinese journal of natural medicines, 2021, Volume: 19, Issue:5 Topics: Circular Dichroism; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Roots	2021
Phytochemical profiling of several Hypericum species identified using genetic markers. Phytochemistry, 2021, Volume: 187 Topics: Chromatography, High Pressure Liquid; Genetic Markers; Hypericum; Phloroglucinol; Phytochemicals; Plant Extracts	2021
Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii. Fitoterapia, 2021, Volume: 153 Topics: China; Hypericum; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Components, Aerial; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Terpenes	2021
Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors. Fitoterapia, 2021, Volume: 153 Topics: Animals; Antioxidants; Cell Line; China; Ferroptosis; Hypericum; Mice; Molecular Structure; Phloroglucinol; Phytochemicals	2021
Structural Revision of Hyperibrin B and Hyperscabrones H and I by Biosynthetic Considerations, NMR Analysis, and Chemical Synthesis. Journal of natural products, 2021, 07-23, Volume: 84, Issue:7 Topics: Biological Products; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum perforatum and absolute configurations assignment of previously reported analogues. Bioorganic chemistry, 2021, Volume: 114 Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hypericum; Immunosuppressive Agents; Lipopolysaccharides; Molecular Structure; Neuroprotective Agents; PC12 Cells; Phloroglucinol; Rats; Structure-Activity Relationship	2021
Discovery of bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii. Bioorganic chemistry, 2021, Volume: 115 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Humans; Hypericum; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; Phloroglucinol; Polycyclic Compounds; RAW 264.7 Cells; Structure-Activity Relationship	2021
Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential. Planta medica, 2021, Volume: 87, Issue:14 Topics: Anti-Inflammatory Agents; Endothelial Cells; Hypericum; Molecular Structure; Phloroglucinol; Prenylation	2021
[Research progress of polycyclic polyprenylated acylphloroglucinols natural products]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021, Volume: 46, Issue:12 Topics: Biological Products; Hypericum; Molecular Structure; Phloroglucinol	2021
Homoadamantane and Adamantane Acylphloroglucinols from Hypericum hirsutum. Planta medica, 2021, Volume: 87, Issue:14 Topics: Adamantane; Endothelial Cells; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2021
Hyperpatulones C-G, new spirocyclic polycyclic polyprenylated acylphloroglucinols from the leaves of Hypericum patulum. Fitoterapia, 2021, Volume: 155 Topics: alpha-Glucosidases; China; Glycoside Hydrolase Inhibitors; Hypericum; Molecular Structure; Phloroglucinol; Phytochemicals; Plant Leaves	2021
Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity. Phytochemistry, 2022, Volume: 193 Topics: Cyclooxygenase 2; Flowers; Hypericum; Molecular Docking Simulation; Molecular Structure; Phloroglucinol	2022
Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species. Phytochemical analysis : PCA, 2022, Volume: 33, Issue:3 Topics: Anthracenes; Chromatography, Thin Layer; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Terpenes	2022
[Polycyclic polyprenylated acylphloroglucinols from Hypericum species and their biological activities]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021, Volume: 46, Issue:19 Topics: Flavonoids; Hypericum; Molecular Structure; Phloroglucinol; Xanthones	2021
Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum. Fitoterapia, 2022, Volume: 156 Topics: Analysis of Variance; Blotting, Western; Cell Death; Cell Proliferation; Heat-Shock Proteins; HeLa Cells; Humans; Hypericum; Magnetic Resonance Spectroscopy; Phloroglucinol; Plant Extracts; Prenylation; Time-Lapse Imaging; X-Ray Diffraction	2022
Four new polyprenylated acylphloroglucinol derivatives from Journal of Asian natural products research, 2022, Volume: 24, Issue:11 Topics: Hep G2 Cells; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2022
Four new polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii and their glucose uptake bioactivities. Fitoterapia, 2022, Volume: 159 Topics: Circular Dichroism; Glucose; Hypericum; Molecular Structure; Phloroglucinol	2022
Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells. International journal of molecular sciences, 2022, Mar-10, Volume: 23, Issue:6 Topics: beta Catenin; Colonic Neoplasms; HCT116 Cells; Humans; Hypericum; Phloroglucinol; Terpenes; Wnt Signaling Pathway	2022
Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum. Phytochemistry, 2022, Volume: 198 Topics: Animals; Hypericum; Immunosuppressive Agents; Mice; Molecular Structure; Monoterpenes; Phloroglucinol	2022
Kiiacylphnols A-H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim. Phytochemistry, 2022, Volume: 199 Topics: Apoptosis; Circular Dichroism; Hypericum; Molecular Structure; Phloroglucinol	2022
Convergent gene clusters underpin hyperforin biosynthesis in St John's wort. The New phytologist, 2022, Volume: 235, Issue:2 Topics: Hypericum; Multigene Family; Phloroglucinol; Phylogeny; Plant Extracts; Plant Oils; Terpenes	2022
Discovery of dearomatized isoprenylated acylphloroglucinols with colon tumor suppressive activities in mice via inhibiting NFκB-FAT1-PDCD4 signaling activation. European journal of medicinal chemistry, 2022, Sep-05, Volume: 239 Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cadherins; Cell Line, Tumor; Colonic Neoplasms; Humans; Hypericum; Mice; Phloroglucinol; RNA-Binding Proteins; Signal Transduction	2022
Ascyrones A-E, type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron. Chinese journal of natural medicines, 2022, Volume: 20, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Hypericum; Molecular Structure; PC12 Cells; Phloroglucinol; Rats	2022
Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum scabrum. Fitoterapia, 2022, Volume: 161 Topics: Cell Line; Hypericum; Molecular Structure; Phloroglucinol	2022
Diverse polycyclic polyprenylated acylphloroglucinols with anti-neuroinflammatory activity from Hypericum beanii. Bioorganic chemistry, 2022, Volume: 127 Topics: Hypericum; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2022
Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage. Bioorganic chemistry, 2022, Volume: 128 Topics: Apoptosis; Cell Cycle Checkpoints; Humans; Hypericum; MCF-7 Cells; Molecular Structure; Oxidative Stress; Phloroglucinol	2022
Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity. Phytochemistry, 2022, Volume: 203 Topics: Acetaminophen; Cyclopropanes; Hypericum; Molecular Structure; Phloroglucinol	2022
Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Molecules (Basel, Switzerland), 2022, Sep-13, Volume: 27, Issue:18 Topics: Acetaminophen; Furans; Hypericum; Molecular Structure; Phloroglucinol; Spiro Compounds	2022
Discovery of bicyclic polyprenylated acylphloroglucinols from Hypericum himalaicum with glucose transporter 4 translocation activity. Bioorganic chemistry, 2022, Volume: 129 Topics: Circular Dichroism; Glucose Transport Proteins, Facilitative; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2022
Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs. Molecular psychiatry, 2022, Volume: 27, Issue:12 Topics: Animals; Antidepressive Agents; Hypericum; Mice; Phloroglucinol; Terpenes; TRPC6 Cation Channel	2022
Caged polycyclic polyprenylated acylphloroglucinols as Ca Chemical communications (Cambridge, England), 2022, Nov-24, Volume: 58, Issue:94 Topics: Animals; Humans; Hypericum; Mice; Molecular Structure; Phloroglucinol	2022
Polycyclic Polyprenylated Acylphloroglucinols Bearing a Lavandulyl-Derived Substituent from Journal of natural products, 2022, 12-23, Volume: 85, Issue:12 Topics: Fruit; Garcinia; Humans; Hypericum; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Phloroglucinol	2022
Hyperxylones A and B, two polycyclic polyprenylated acylphloroglucinols with a benzoyl substituted bicyclo[3.2.1]octane core from Hypericum beanii. Fitoterapia, 2023, Volume: 165 Topics: Hypericum; Molecular Structure; Octanes; Phloroglucinol	2023
[Two pairs of phloroglucinol enantiomers from Hypericum wightianum and their stereochemical structures]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023, Volume: 48, Issue:2 Topics: Drugs, Chinese Herbal; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2023
Cytotoxic and Antioxidant Activity of Molecules (Basel, Switzerland), 2023, Feb-03, Volume: 28, Issue:3 Topics: Antineoplastic Agents; Antioxidants; Bridged Bicyclo Compounds; Humans; Hypericum; Hypoxia; Melanoma; Neoplastic Processes; Phloroglucinol; Plant Extracts; Terpenes; Tumor Microenvironment	2023
Structurally diverse spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum ascyron Linn. and their anti-tumor activity. Phytochemistry, 2023, Volume: 212 Topics: Animals; Cell Line; Humans; Hypericum; Molecular Structure; Phloroglucinol; Zebrafish	2023
Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia, 2023, Volume: 169 Topics: Anti-Inflammatory Agents; Hypericum; Lipopolysaccharides; Molecular Structure; Phloroglucinol	2023
Structure Revision of Type B Polycyclic Polyprenylated Acylphloroglucinols Fused to a Partly Reduced Furan Ring. Journal of natural products, 2023, 10-27, Volume: 86, Issue:10 Topics: Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol	2023
Prenyllongnols A-D, New Prenylated Acylphloroglucinols that Fight Concanavalin A-Induced Autoimmune Hepatitis. Journal of agricultural and food chemistry, 2023, Nov-22, Volume: 71, Issue:46 Topics: Animals; Concanavalin A; Hepatitis, Autoimmune; Hypericum; Immunosuppressive Agents; Mice; Phloroglucinol	2023