phloroglucinol has been researched along with hyperforin in 361 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.55) | 18.7374 |
| 1990's | 23 (6.37) | 18.2507 |
| 2000's | 193 (53.46) | 29.6817 |
| 2010's | 124 (34.35) | 24.3611 |
| 2020's | 19 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bystrov, NS; Chernov, BK; Chervin, II; Dobrynin, VN; Kolosov, MN | 1 |
| Bystrov, NS; Chernov, BK; Dobrynin, VN; Gupta, ShR; Kolosov, MN | 1 |
| Erdelmeier, CA | 1 |
| Chatterjee, SS; Erdelmeier, C; Koch, E; Nöldner, M | 1 |
| Hafner, U; Müller, WE; Rolli, M; Schäfer, C; Singer, A; Wonnemann, M | 1 |
| Bhattacharya, SK; Chakrabarti, A; Chatterjee, SS | 1 |
| Dimpfel, W; Mannel, M; Schober, F | 1 |
| Biber, A; Chatterjee, SS; Fischer, H; Römer, A | 1 |
| Dimpfel, W; Sauer, S; Schellenberg, R | 1 |
| Baghai, T; Kieser, M; Laakmann, G; Schüle, C | 1 |
| Bhattacharya, SK; Chatterjee, SS; Müller, WE; Singer, A; Wonnemann, M | 1 |
| Djarmati, Z; Jankov, R; Juranić, N; Macura, S; Milosavljević, S; Trifunović, S; Vajs, V | 1 |
| Orth, HC; Rentel, C; Schmidt, PC | 1 |
| Chatterjee, SS; Kaehler, ST; Philippu, A; Sinner, C | 1 |
| Firenzuoli, F; Gori, L | 1 |
| Pelz, K; Schempp, CM; Schöpf, E; Simon, JC; Wittmer, A | 1 |
| Müller, WE; Singer, A; Wonnemann, M | 3 |
| Campling, G; Chi, J; Cowen, PJ; Franklin, M; Hockney, R; McGavin, C; Reed, A; Whale, RW | 1 |
| Verweij, PE; Voss, A | 1 |
| Fiebich, BL; Heinrich, M; Kammerer, N; Langosch, JM; Lieb, K | 1 |
| Ebrey, RJ | 1 |
| Chatterjee, S; Filippov, V; Krishtal, O; Lishko, P; Maximyuk, O; Nöldner, M | 1 |
| Chi, JD; Franklin, M | 1 |
| Appendino, G; Bombardelli, E; Jakupovic, J; Verotta, L | 1 |
| Lüdtke, R; Schempp, CM; Schöpf, E; Simon, JC; Simon-Haarhaus, B; Winghofer, B | 1 |
| Collins, JL; Goodwin, B; Jones, SA; Kliewer, SA; Moore, LB; Serabjit-Singh, CJ; Willson, TM; Wisely, GB | 1 |
| Obach, RS | 1 |
| Biron, CR | 1 |
| Chatterjee, S; Fisunov, A; Krishtal, O; Lozovaya, N; Nöldner, M; Tsintsadze, T | 1 |
| Agostini, M; Chatterjee, VK; Love, J; Schwabe, JW; Wentworth, JM | 1 |
| Poser, W; Vormfelde, SV | 1 |
| Chen, ZL; Hu, LH; Shan, MD | 1 |
| Vogel, G | 1 |
| Agrosi, M; Harrasser, PC; Mischiatti, S; Savio, D | 1 |
| Repcák, M; Tekel'ová, D; Tóth, J; Zemková, E | 1 |
| Hansen, SH; Jensen, AG; Nielsen, EO | 1 |
| Gobbi, M; Mennini, T; Morazzoni, P | 1 |
| Borrelli, F; Di Carlo, G; Ernst, E; Izzo, AA | 1 |
| Hunt, EJ; Lester, CE; Lester, EA; Tackett, RL | 1 |
| Chatterjee, S; Nöldner, M | 1 |
| Biber, A; Chatterjee, SS; Weibezahn, C | 1 |
| Philippu, A | 1 |
| Reichling, J; Saller, R; Weseler, A | 1 |
| Mannel, M; Rommelspacher, H; Siemanowitz, B | 1 |
| Baghai, T; Ferrera, A; Laakmann, G; Schüle, C | 1 |
| Franke, L; Uebelhack, R | 1 |
| Müller, WE; Siebert, B; Singer, A; Wonnemann, M | 1 |
| Baumeister, A; Dressman, J; Kaunzinger, A; Schubert-Zsilovecz, M; Westerhoff, K; Wilke, A; Wurglics, M | 1 |
| Eckert, GP; Müller, WE | 1 |
| Cowen, PJ; Franklin, M | 1 |
| De Montis, MG; Gambarana, C; Giachetti, D; Masi, F; Morazzoni, P; Rinaldi, M; Tolu, PL | 1 |
| Gobbi, M; Mennini, T; Moia, M; Morizzoni, P; Pirona, L | 1 |
| Chatterjee, SS; Germane, S; Klusa, V; Nöldner, M | 1 |
| Chatterjee, SS; Koch, E | 1 |
| Calapai, G; Caputi, AP; Ciliberto, G; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A | 1 |
| Chatterjee, SS; Heinen, M; Langosch, JM; Nöldner, M; Walden, J; Zhou, XY | 1 |
| Fuzzati, N; Gabetta, B; Strepponi, I; Villa, F | 1 |
| de los Reyes, GC; Koda, RT | 2 |
| Coutts, RT; Gu, LD; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ | 1 |
| Hansen, SH; Jensen, AG | 1 |
| Gobbi, M; Mennini, T | 2 |
| Bauer, S; Graubaum, HJ; Roots, I; Störmer, E | 1 |
| Borner, C; Gilb, B; Kaufmann, T; Kersten, A; Kirkin, V; Kiss, J; Schempp, CM; Simon, JC; Simon-Haarhaus, B; Sleeman, JP; Termeer, CC | 1 |
| Bray, BJ; Brennan, NJ; Menkes, DB; Perry, NB; Rosengren, RJ | 1 |
| Buchholzer, ML; Chatterjee, SS; Dvorak, C; Klein, J | 1 |
| Herskowitz, I | 1 |
| Appendino, G; Belloro, E; Bianchi, F; Bombardelli, E; Lovati, M; Sterner, O; Verotta, L | 1 |
| Young, DG; Zeng, D | 1 |
| Kovar, KA; Rager, I; Roos, G; Schmidt, PC | 1 |
| Bhattacharya, SK; Ghosal, S; Muruganandam, AV | 1 |
| Hirshfeld, A; Mazur, Y; Rehavi, M; Roz, N | 1 |
| Bonn, GK; Huck, CW; Pirker, R | 1 |
| Davies, JA; Marsh, WL | 1 |
| Adam, P; Arigoni, D; Bacher, A; Eisenreich, W | 1 |
| Biber, A; Erdelmeier, C; Lang, F | 1 |
| Ang, CY; Cui, Y; Gurley, B; Leakey, J | 1 |
| Albert, D; Dingermann, T; Müller, WE; Steinhilber, D; Werz, O; Zündorf, I | 1 |
| Caccia, S; Cervo, L; Ekalle-Soppo, CB; Guiso, G; Morazzoni, P; Rozio, M | 1 |
| Baraldi, C; Baraldi, M; Rivasi, M; Zanoli, P | 1 |
| Murch, SJ; Rupasinghe, HP; Saxena, PK | 1 |
| Berger Büter, K; Bobirnac, I; Lübbert, H; Schaffner, W; Schoeffter, P; Simmen, U; Ullmer, C | 1 |
| Dressman, J; Kaunzinger, A; Schubert-Zsilavecz, M; Westerhoff, K; Wurglics, M | 1 |
| Müller, WE | 1 |
| Verotta, L | 1 |
| Schmitt, J | 1 |
| Davis-Searles, PR; Kliewer, SA; Lambert, MH; Maglich, JM; Moore, LB; Noble, SM; Redinbo, MR; Watkins, RE; Wisely, GB | 1 |
| Hezel, S; Schempp, CM; Simon, JC | 1 |
| Fischer, L; Rådmark, O; Steinhilber, D; Szellas, D; Werz, O | 1 |
| Hübner, AT | 1 |
| Rehavi, M; Roz, N | 2 |
| Butterweck, V; Christoffel, V; Nahrstedt, A; Petereit, F; Spengler, B; Winterhoff, H | 1 |
| Schmidt, PC | 1 |
| Schubert-Zsilavecz, M; Wurglics, M | 2 |
| Juranić, N; Karadzić, I; Macura, S; Milosavljević, S; Trifunović, S; Vajs, V; Vugdelija, S | 1 |
| Bommer, S; Hostanska, K; Reichling, J; Saller, R; Weber, M | 1 |
| Caccia, S; Cantoni, L; Hauri, L; Mangolini, A; Rozio, M | 1 |
| Butterweck, V; Herkenham, M; Winterhoff, H | 1 |
| Bommer, S; Hostanska, K; Krasniqi, B; Saller, R; Weber, M | 1 |
| Blumberg, B; Errandi, J; Forman, BM; Grün, F; Inoue, S; Lin, M; Mallick, S; Pham, H; Romero, K; Sun, A; Tabb, MM; Zhou, C | 1 |
| Gibson, DM; Kaufman, PB; Kirakosyan, A; Sirvent, TM | 1 |
| Anand, R; Gupta, VK; Handa, G; Khajuria, RK; Puri, SC; Qazi, GN; Suri, OP; Verma, N | 1 |
| Chen, Y; Ferguson, SS; Goldstein, JA; Negishi, M | 1 |
| Froestl, B; Müller, WE; Steiner, B | 1 |
| Blume, HH; Dingermann, T; Eckert, GP; Karas, M; Keller, JH; Müller, WE; Schubert-Zsilavecz, M; Tawab, MA; Volmer, DA | 1 |
| Ciochina, R; Grossman, RB | 1 |
| De Montis, MG; Gambarana, C; Giachetti, D; Grappi, S; Leggio, B; Nanni, G; Tolu, P; Usai, M | 1 |
| Butterweck, V; Simbrey, K; Winterhoff, H | 1 |
| Ang, CY; Beger, RD; Cui, Y; Heinze, TM; Hu, L; Leakey, J | 1 |
| Gott, M; Grayson, B; Hanna, M; Neill, JC; Smith, AG; Sunter, A; Wright, CW | 1 |
| Gibson, DM; Krasnoff, SB; Sirvent, TM | 1 |
| Barecki-Roach, M; Johnson, WW; Wang, EJ | 1 |
| Haslinger, E; Kaiser, CS; Römpp, H; Schmidt, PC; Seger, C | 1 |
| Feisst, C; Werz, O | 1 |
| Chatterjee, SS; Koch, E; Schrattenholz, A; Schroer, K | 1 |
| Ang, CY; Cai, H; Cui, YY; Frye, R; Hutzler, JM; Komoroski, BJ; Lehmann, T; Strom, SC; Tracy, TS; Venkataramanan, R; Zhang, S | 1 |
| Buchholzer, ML; Chatterjee, SS; Hartmann, J; Kiewert, C; Klein, J | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Eggenreich, K; Likussar, W; Michelitsch, A; Rückert, U; Wintersteiger, R; Wurglics, M | 1 |
| Funicello, M; Gobbi, M; Mennini, T; Moia, M; Morazzoni, P; Riva, A | 1 |
| Eckert, GP; Jourdan, C; Karas, M; Keller, JH; Müller, WE; Schubert-Zsilavecz, M; Volmer, DA | 1 |
| Appendino, G; Borsarini, A; Calabrese, F; Caniato, R; Dell'Aica, I; Della Barbera, M; Donà, M; Donella-Deana, A; Garbisa, S; Pezzato, E; Sartor, L | 1 |
| Burhenne, J; Haefeli, WE; Martin-Facklam, M; Riedel, KD; Rieger, K; Walter-Sack, I | 1 |
| Ang, CY; Cui, Y; DiNovi, M; Freeman, JP; Heinze, TM; Hu, L; Kozak, K; Liu, FF; Luo, W; Mattia, A | 1 |
| Bauer, S; Budde, K; Frank, B; Johne, A; Mai, I; Perloff, ES; Roots, I; Uehleke, B | 1 |
| Dienel, A; Trautmann-Sponsel, RD | 1 |
| Zanoli, P | 1 |
| Appendino, G; Bombardelli, E; Lovaglio, E; Sterner, O; Verotta, L | 1 |
| Ashraf-Khorassani, M; Taylor, LT; Wang, Z | 1 |
| Fricker, G; Kressmann, S; Müller, WE; Weber, CC | 1 |
| Burhenne, J; Haefeli, WE; Martin-Facklam, M; Mikus, G; Riedel, KD; Rieger, K | 1 |
| Gartner, M; Giannis, A; Müller, T; Simon, JC; Sleeman, JP | 1 |
| Blumberg, B; Grün, F; Sadatrafiei, A; Sun, A; Tabb, MM; Zhou, C | 1 |
| Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R | 1 |
| Beerhues, L; Beuerle, T; Boubakir, Z; Liu, B | 1 |
| Beerhues, L; Beuerle, T; Boubakir, Z; El-Moghazy, SA; Klingauf, P; Mellenthin, A | 1 |
| Caccia, S; Fracasso, C; Morazzoni, P; Riva, A; Rozio, M | 1 |
| Burbassi, S; Caccia, S; Canetta, A; Cervo, L; Ekalle-Soppo, CB; Gobbi, M; Guiso, G; Mennini, T; Morazzoni, P; Pirona, L; Riva, A; Rozio, M | 1 |
| Henke, B; Müller, WE; Singer, A; Treiber, K | 1 |
| Bässler, D; Schulz, HU; Schürer, M; Weiser, D | 2 |
| Davidson, JR; Gadde, KM; Greenblatt, DJ; Harlan, W; Krishnan, KR; Parker, CB; Ritz, L; Shader, RI; Vitiello, B | 1 |
| Altieri, V; Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Montanaro, V | 1 |
| Carenzi, GE; Jeso, V; Nicolaou, KC | 1 |
| Martínez-Poveda, B; Medina, MA; Quesada, AR | 1 |
| Banz, WJ; Shay, NF | 1 |
| Cucculelli, M; Massi, M; Mattioli, L; Perfumi, M | 1 |
| Egorin, MJ; Komoroski, BJ; Parise, RA; Strom, SC; Venkataramanan, R | 1 |
| Krusekopf, S; Roots, I | 1 |
| Fiamegos, YC; Gioti, EM; Skalkos, DC; Stalikas, CD | 1 |
| Averbeck, M; Kirkin, V; Kiss, J; Kremer, B; Schempp, CM; Simon, JC; Simon-Haarhaus, B; Sleeman, J; Termeer, CC | 1 |
| Bauer, S; Drewelow, B; Frank, B; Klammt, S; Kundt, G; Majcher-Peszynska, J; Miekisch, W; Mueller, SC; Mundkowski, RG; Sievers, H; Uehleke, B | 1 |
| Lawvere, S; Mahoney, MC | 1 |
| Ashton, D; Chandrasekera, DH; Heinrich, M; Middleton, R; Welham, KJ | 1 |
| Furumoto, M; Haito, S; Ito, M; Kawai, Y; Miyamoto, K; Terao, J | 1 |
| Billard, C; Ensaf, A; Faussat, AM; Fourneron, JD; Kolb, JP; Naït-Si, Y; Quiney, C; Salanoubat, C | 1 |
| Amores-Sánchez, MI; Martínez-Poveda, B; Medina, MA; Quesada, AR | 1 |
| Billard, C; Fourneron, JD; Kolb, JP; Mirshahi, P; Quiney, C | 1 |
| Butterweck, V; Derendorf, H; Drewelow, B; Frank, B; Madabushi, R | 1 |
| Klier, CM; Lee, A; Lenz, G; Saria, A; Schäfer, MR; Schmid-Siegel, B; Zernig, G | 1 |
| Smelcerovic, A; Spiteller, M; Zuehlke, S | 1 |
| Gao, Y; Wang, SQ; Wang, YG | 1 |
| Albert, D; Feisst, C; Verotta, L; Werz, O | 1 |
| Billard, C; Fourneron, JD; Kolb, JP; Quiney, C; Salanoubat, C | 1 |
| Cerpa, W; Dinamarca, MC; Garrido, J; Hancke, JL; Inestrosa, NC | 1 |
| Daneshfar, R; Eckert, GP; Müller, WE; Sleno, L; Volmer, DA | 1 |
| Abbruscato, T; Bickel, U; Kiewert, C; Klein, J; Kumar, V; Mdzinarishvili, A; van der Schyf, CJ | 1 |
| Beerhues, L | 1 |
| Duke, CC; Duke, RK; Hook, JM; Lee, JY; Tran, VH | 1 |
| Appendino, G; Bombardelli, E; Brun, R; Verotta, L | 1 |
| Agostini, C; Albini, A; Benelli, R; Brunetta, E; Cabrelle, A; Calabrese, F; Colalto, C; Dell'Aica, I; Garbisa, S; Lorusso, G; Niero, R; Piazza, F; Sartor, L | 1 |
| Cao, J; Chan, E; Chen, X; Duan, W; Hu, ZP; Huang, M; Wen, JY; Yang, XX; Yu, XQ; Zhou, SF | 1 |
| Hohtola, A; Hokkanen, J; Karppinen, K; Mattila, S; Tolonen, A | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S | 1 |
| Biggin, S; Caniato, R; Dell'Aica, I; Garbisa, S | 1 |
| Häberlein, H; Prenner, L; Sieben, A; Weiser, D; Zeller, K | 1 |
| Jäger, AK; Jørgensen, LB; Soelberg, J | 1 |
| Büttner, A; Gey, C; Giannis, A; Hennig, L; Kyrylenko, S; Nguyen, LH; Pham, HD | 1 |
| Bornancin, A; Della Loggia, R; Morazzoni, P; Pace, R; Riva, A; Sosa, S; Tubaro, A | 1 |
| Gödtel-Armbrust, U; Kelber, O; Kroll, U; Metzger, A; Wojnowski, L | 1 |
| Klejdus, B; Kuban, V; Pavlík, M; Vacek, J | 1 |
| Klejdus, B; Kubán, V; Vacek, J | 1 |
| Abrahamyan, A; Beerhues, L; Boubakir, Z; Bringmann, G; Charchoglyan, A; Ebizuka, Y; Fujii, I; Gulder, TA; Kutchan, TM; Vardapetyan, H | 1 |
| Essin, K; Gollasch, M; Harteneck, C; Henke, B; Kazanski, V; Leuner, K; Müller, M; Müller, WE | 1 |
| Birt, DF; Delate, K; Dixon, PM; Hammer, KD; Hillwig, ML; Murphy, PA; Solco, AK; Wurtele, ES | 1 |
| Rund, D | 1 |
| Billard, C; Faussat, AM; Kolb, JP; Quiney, C; Salanoubat, C | 1 |
| Kraft, K | 1 |
| Butterweck, V; Schmidt, M | 1 |
| Agostini, C; Brunetta, E; Cabrelle, A; Calzà, L; Carraro, S; D'Intino, G; Dell'Aica, I; Garbisa, S; Melchiori, L; Niero, R; Scquizzato, E | 1 |
| Cirak, C; Radusiene, J | 1 |
| Chancellor, MB; Thomas, CA; Tyagi, P; Tyagi, S; Yoshimura, N | 1 |
| Beffy, P; D'Aleo, V; Lupi, R; Marchetti, P; Masiello, P; Menegazzi, M; Novelli, M; Suzuki, H; Tedeschi, E; Zoratti, E | 1 |
| Canegallo, L; Carrassi, A; Demarosi, F; Lodi, G; Sardella, A; Tarozzi, M | 1 |
| Bertoli, A; Giovannini, A; Guardo, AD; Mazzetti, M; Pistelli, L; Ruffoni, B; Spinelli, G | 1 |
| Cirak, C; Ivanauskas, L; Janulis, V; Radusiene, J | 3 |
| Drewelow, B; Frank, B; Klammt, S; Kundt, G; Lehnfeld, R; Majcher-Peszynska, J; Mueller, SC; Mundkowski, RG; Sievers, H; Thurow, K; Uehleke, B | 1 |
| Akrout, I; Billard, C; Kolb, JP; Mirshahi, M; Zaher, M | 1 |
| Beschmann, H; Boehncke, WH; Essin, K; Gollasch, M; Harteneck, C; Hill, K; Leuner, K; Müller, M; Müller, WE; Rubant, S; Schempp, CM | 1 |
| Kiss, J | 1 |
| Bondesson, U; Hedeland, M; Knutson, L; Lennernäs, H; Lundahl, A | 1 |
| Bouron, A; Brinkmeier, H; Kunert-Keil, C; Lucke, S; Tu, P | 1 |
| Khalifa, AE; Mohamed, MR; Sabry, GM; Sabry, NA; Tadros, MG; Youssef, AM | 2 |
| Bauer, B; Fricker, G; Ott, M | 1 |
| Chen, J; Chen, X; Du, J; Guan, S; He, YW; Huang, M; Li, JL; Su, QB; Wang, XD; Zeng, J; Zhang, JX; Zhou, SF | 1 |
| Albini, A; Garbisa, S; Generoso, L; Lorusso, G; Noonan, DM; Sogno, I; Vannini, N | 1 |
| Bruyère, F; Gartner, M; Giannis, A; Noël, A; Plaumann, D; Rothley, M; Schacht, V; Schmid, A; Sleeman, JP; Thiele, W; Yektaoglu, A | 1 |
| Dodt, G; Feisst, C; Fischer, L; Franke, L; Hoernig, C; Hoffmann, M; Koeberle, A; Pergola, C; Rådmark, O; Rakonjac, M; Rossi, A; Sautebin, L; Schneider, G; Steinhilber, D; Werz, O | 1 |
| Kavanagh, DJ; Sarris, J | 1 |
| Borsarini, A; Caniato, R; Filippini, R; Piovan, A | 1 |
| Anthony, MN; Dinchuk, JE; Dulac, HA; Grace, JE; Kim, S; Mosure, KW; Orcutt, T; Pizzano, J; Sauer, MB; Simmermacher, J; Sinz, M; Vuppugalla, R; Zoeckler, ME | 1 |
| Bouron, A; Gibon, J; Tu, P | 2 |
| Bombardelli, E; Cerpa, W; Hancke, JL; Inestrosa, NC; Marin, PP; Morazzoni, P; Riva, A | 1 |
| Chatterjee, SS; Derksen, S; Fehske, CJ; Gollasch, M; Harteneck, C; Heiser, JH; Leuner, K; Mladenov, MI; Müller, WE; Schneider, G; Schubert, R | 1 |
| Dinamarca, MC; Griffith, TN; Inestrosa, NC; Varela-Nallar, L | 1 |
| Feisst, C; Glaubitz, C; Hoffmann, M; Jakobsson, PJ; Lopez, JJ; Pawelczik, S; Pergola, C; Sorg, BL; Steinhilber, D; Werz, O | 1 |
| Kanai, M; Shi, SL; Shibasaki, M; Shimizu, Y; Usuda, H | 1 |
| Castell, JV; Gómez-Lechón, MJ; Jover, R; Moya, M | 1 |
| Caccia, S; Gobbi, M | 1 |
| Bombardelli, E; Martínez-Poveda, B; Medina, MA; Quesada, AR; Verotta, L | 1 |
| Elstner, EF; Heilmann, J; Kraus, B; Wolff, H | 1 |
| Butterweck, V; Nahrstedt, A | 1 |
| Gilani, AH; Khan, AU | 1 |
| Cavalieri, E; Darra, E; Ebner, FH; Mariotto, S; Suzuki, H | 1 |
| Bradaschia, A; Garbisa, S; Maran, C; Masola, V; Onisto, M; Tassone, E | 1 |
| Hokkanen, J; Mattila, S; Tolonen, A; Turpeinen, M | 1 |
| Bai, G; Cao, X; Ito, Y; Li, Y; Ren, H; Wang, Q; Xu, C | 1 |
| Chen, JP; Li, MM; Liu, JY; Liu, Z; Wang, DM; Wang, R; Wang, SX; Wang, YF; Yang, DP | 1 |
| Barbosa, C; Brustovetsky, N; Brustovetsky, T; Chakraborty, S; Kumar, S; Obukhov, AG | 1 |
| Abuznait, AH; Burk, D; Cain, C; Ingram, D; Kaddoumi, A | 1 |
| Abuznait, AH; Kaddoumi, A; Patrick, SG | 1 |
| Billard, C; Bombarda, I; Marie, JP; Mirshahi, M; Nuraliev, Y; Sharofova, M; Zaher, M | 1 |
| He, F; Liu, JY; Liu, Z; Sun, F; Wang, DM; Wang, R; Wang, YF; Yang, DP | 1 |
| Hatano, T; Inoue, R; Ito, H; Ochi, M; Onoue, S; Seto, Y; Yamada, S | 1 |
| He, J; Kong, J; Li, XM; Nazarali, A; Tan, Q; Wang, Y; Xiao, L; Zhang, D; Zhang, H; Zhang, Y; Zhang, Z | 1 |
| Bouron, A; Gibon, J; Richaud, P | 1 |
| Bauvois, B; Billard, C; Bombarda, I; Merhi, F; Tang, R; Zaher, M | 1 |
| Bauvois, B; Billard, C; Bombarda, I; Kolb, JP; Mathieu, J; Merhi, F; Piedfer, M; Tang, R; Zaher, M | 1 |
| Abrous, DN; Bouron, A; Chevallier, T; Deloulme, JC; Gibon, J; Ladevèze, E | 1 |
| Farag, MA; Wessjohann, LA | 1 |
| Miller, CD; Mortensen, T; Shen, F; Shen, S; Sims, RC; Walsh, MK | 1 |
| Casetti, F; Haag, SF; Kleemann, A; Lademann, J; Meinke, MC; Müller, ML; Schanzer, S; Schempp, CM; Wölfle, U | 1 |
| Caliskan, O; Camas, N; Cirak, C; Radusiene, J; Stanius, Z | 1 |
| Amaral, MD; Calfa, G; Harteneck, C; Inoue, T; Leuner, K; Li, W; Pozzo-Miller, L; Rudolph, S; Schuwald, AM | 1 |
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| Carrubba, A; Lazzara, S; Militello, M; Napoli, E; Saia, S | 1 |
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| Beerhues, L; Behrends, S; Biedermann, E; Füller, J; Gaid, M; Haas, P; Krull, R; Müller-Goymann, C; Scholl, S; Wittstock, U | 1 |
| Grewal, GK; Jajodia, A; Kanojia, N; Kukal, S; Kukreti, R; Misra, R; Muthusamy, K; Nagamani, S; Rawat, C; Singh, KD; Singhal, A | 1 |
| Beerhues, L; Gaid, M; Haas, P; Scholl, S; Zarinwall, A | 1 |
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| Cheng, P; Han, Y; Huang, W; Li, Y; Song, M; Yu, K | 1 |
| Beffy, P; Gregorelli, A; Mascia, F; Masiello, P; Menegazzi, M; Novelli, M; Porozov, S; Vantaggiato, C | 1 |
| Beißner, N; Böl, M; Bolea Albero, A; Füller, J; Glasmacher, B; Kellner, T; Lauterboeck, L; Liang, J; Müller-Goymann, CC; Reichl, S | 1 |
| Chrubasik-Hausmann, S; McLachlan, AJ; Vlachojannis, J | 1 |
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| Chen, WT; Chen, YK; Hsu, FT; Lin, SS | 1 |
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| Fedoročko, P; Sačková, V; Šemeláková, M | 1 |
| Liu, H; Yao, H; Yao, S; Yu, P; Yuan, SY; Zhang, JC; Zhang, Y | 1 |
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| Cao, Z; Han, Y; Li, Y; Shao, B; Song, M; Wang, H; Wang, P; Xu, F; Yu, H; Yu, K | 1 |
| Fertig, O; Meyer Zu Schwabedissen, HE; Potterat, O; Schäfer, AM; Seibert, I | 1 |
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| Cerón-Carrasco, JP; den Haan, H; Emerce, E; Orhan, IE; Peña-García, J; Pérez-Sánchez, H; Senol Deniz, FS; Skalicka-Wozniak, K; Traedal-Henden, S | 1 |
| Friedland, K; Krakowska, A; Muszyńska, B; Nowak, G; Opoka, W; Pochwat, B; Rafało-Ulińska, A; Szewczyk, B | 1 |
| Babinčák, M; Buríková, M; Fedoročko, P; Jendželovská, Z; Jendželovský, R; Košuth, J; Majerník, M; Ševc, J; Tonelli Gombalová, Z | 1 |
| Carrubba, A; Lazzara, S; Napoli, E | 1 |
| Gottschaldt, M; Kretzer, C; Schubert, S; Schubert, US; Shkodra-Pula, B; Traeger, A; Voelker, S; Werz, O | 1 |
| Chen, WT; Chung, JG; Hsu, FT; Wu, CT | 1 |
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| Altschmied, L; D'Auria, JC; Ravindran, BM; Rizzo, P; Rutten, T | 1 |
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| Maimone, TJ; Shen, X; Thach, DQ; Ting, CP | 1 |
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| Bo, X; Chen, S; Cui, C; Guan, J; Han, J; Ke, X; Li, Z; Liu, C; Liu, H; Liu, J; Liu, X; Lu, J; Peng, C; Sun, H; Tan, C; Wang, R; Wu, P; Xu, X; Yang, D; Zhang, Y | 1 |
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| Alzheimer, C; Braeuning, A; El Hamdaoui, Y; Friedland, K; Fritz, N; Heinrich, M; Hellmich, UA; Lichtenstein, D; Müller, CP; Nowak, G; Nürnberg, B; Schäfer, MKE; Schirmeister, T; Schwickert, K; Tran, MA; Treccani, G; Weikert, D; Ye, L; Zheng, F | 1 |
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43 review(s) available for phloroglucinol and hyperforin
| Article | Year |
|---|---|
St John's wort: Prozac from the plant kingdom.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Biological Availability; Bridged Bicyclo Compounds; Depression; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Leaves; Plants, Medicinal; Selective Serotonin Reuptake Inhibitors; Terpenes | 2001 |
In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Electroshock; Fear; Hypericum; Locus Coeruleus; Neurotransmitter Agents; Phloroglucinol; Plant Extracts; Terpenes | 2001 |
A current review of the antimicrobial activity of Hypericum perforatum L.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Humans; Hypericum; Phloroglucinol; Plant Extracts; Terpenes | 2001 |
[Hyperforin in St. John's wort--drug, extraction and preparations].
Topics: Bridged Bicyclo Compounds; Drug Stability; Hypericum; Phloroglucinol; Terpenes | 2002 |
Current St John's wort research from mode of action to clinical efficacy.
Topics: Animals; Antidepressive Agents; Behavior; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Norepinephrine; Phloroglucinol; Phytotherapy; Receptors, Serotonin; Serotonin; Synaptic Transmission; Terpenes | 2003 |
Hypericum perforatum, a source of neuroactive lead structures.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Depression; Humans; Hypericum; Mass Spectrometry; Phloroglucinol; Phytotherapy; Terpenes | 2003 |
[Formulation of St. John's wort extract. A medicinal obstacle course].
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Drug Compounding; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Solvents; Terpenes | 2003 |
[Charge conformity and biopharmaceutic characterization. St. John's Wort extract preparations in comparison].
Topics: Animals; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Flavonoids; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2003 |
The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Culture Techniques; Hypericum; Perylene; Phloroglucinol; Plants, Medicinal; Terpenes | 2004 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neurotransmitter Agents; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Receptors, Dopamine D1; Receptors, Opioid; Terpenes | 2004 |
Safety of Hypericum extract in mildly to moderately depressed outpatients: a review based on data from three randomized, placebo-controlled trials.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypericum; Multicenter Studies as Topic; Phloroglucinol; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Risk; Terpenes | 2004 |
Role of hyperforin in the pharmacological activities of St. John's Wort.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Disease Models, Animal; Drug Interactions; Humans; Hypericum; Phloroglucinol; Terpenes | 2004 |
Regulation of gene transcription by botanicals: novel regulatory mechanisms.
Topics: Animals; Bridged Bicyclo Compounds; Catechin; Gene Expression Regulation; Glycine max; Humans; Isoflavones; Peroxisome Proliferator-Activated Receptors; Phloroglucinol; Plants; Pregnane X Receptor; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Resveratrol; Sirtuins; Stilbenes; Terpenes; Transcription, Genetic; Ubiquitin | 2005 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; Treatment Outcome | 2005 |
Hyperforin: more than an antidepressant bioactive compound?
Topics: Angiogenesis Inhibitors; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Bridged Bicyclo Compounds; Humans; Hypericum; Phloroglucinol; Terpenes | 2006 |
Hyperforin in St. John's wort drug interactions.
Topics: Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Humans; Hypericum; Pharmaceutical Preparations; Phloroglucinol; Plants, Medicinal; Terpenes | 2006 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2006 |
[The induction of CYP3A regulated by pregnane X receptor and its significance in drug metabolism].
Topics: Animals; Bridged Bicyclo Compounds; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Drug Design; Drug Interactions; Enzyme Induction; Humans; Lithocholic Acid; Phloroglucinol; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Terpenes; Transcription Factors | 2006 |
Hyperforin, a new lead compound against the progression of cancer and leukemia?
Topics: Anti-Infective Agents; Antidepressive Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Humans; Neoplasms; Phloroglucinol; Terpenes | 2006 |
Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Catechin; Humans; Hypericum; Matrix Metalloproteinases; Neovascularization, Pathologic; Phloroglucinol; Pulmonary Fibrosis; Tea; Terpenes | 2007 |
[Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
[New developments in hypericum extracts: data on efficacy and interactions].
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Child; Citalopram; Depression; Double-Blind Method; Drug Interactions; Female; Fluoxetine; Humans; Hypericum; Male; Phloroglucinol; Phytotherapy; Placebos; Plant Extracts; Pregnancy; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Somatoform Disorders; Terpenes; Time Factors; Treatment Outcome | 2007 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hypericum; Ice; Meta-Analysis as Topic; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2007 |
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
Topics: Anthracenes; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bridged Bicyclo Compounds; Humans; Hypericum; Kava; Mood Disorders; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2009 |
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cognition Disorders; Hypericum; Mice; Mice, Transgenic; Neuroprotective Agents; Phloroglucinol; Receptors, N-Methyl-D-Aspartate; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel | 2010 |
St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Nootropic Agents; Permeability; Perylene; Phloroglucinol; Plant Preparations; Psychotropic Drugs; Terpenes | 2009 |
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Molecular Structure; Perylene; Phloroglucinol; Plant Preparations; Plants, Medicinal; Terpenes | 2010 |
Use of STAT1 inhibitors in the treatment of brain I/R injury and neurodegenerative diseases.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Catechin; Humans; Janus Kinases; Molecular Structure; Neurodegenerative Diseases; Neuroprotective Agents; Phloroglucinol; Reperfusion Injury; Signal Transduction; STAT1 Transcription Factor; Terpenes | 2011 |
Mechanistic insights into the antileukemic activity of hyperforin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukocytes; Neoplasm Proteins; Phloroglucinol; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Terpenes | 2013 |
[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature].
Topics: Anthracenes; Antidepressive Agents; Brain; Hypericum; Neurons; Perylene; Phloroglucinol; Terpenes | 2014 |
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes | 2014 |
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Signal Transduction; Terpenes | 2014 |
Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Humans; Hypericum; Phloroglucinol; Photosensitizing Agents; Terpenes | 2014 |
Hyperforin: To Be or Not to Be an Activator of TRPC(6).
Topics: Animals; Cytochrome P-450 Enzyme Inducers; Drug Stability; Humans; Phloroglucinol; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel | 2015 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Terpenes | 2017 |
Biotechnological production of hyperforin for pharmaceutical formulation.
Topics: Biotechnology; Drug Compounding; Hypericum; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Plant Roots; Technology, Pharmaceutical; Terpenes | 2018 |
Clinical risks of St John's Wort (Hypericum perforatum) co-administration.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Depression; Herb-Drug Interactions; Humans; Hypericum; Pharmacokinetics; Phloroglucinol; Plant Preparations; Terpenes | 2017 |
Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs.
Topics: Cornea; Drug Compounding; Drug Evaluation, Preclinical; Humans; Models, Biological; Phloroglucinol; Skin; Terpenes; Tissue Engineering | 2018 |
Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content.
Topics: Animals; Dose-Response Relationship, Drug; Herb-Drug Interactions; Humans; Hypericum; Pharmacokinetics; Phloroglucinol; Plant Extracts; Terpenes | 2019 |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in
Topics: Anthracenes; Antidepressive Agents; Antineoplastic Agents; Europe; Humans; Hypericum; Perylene; Phloroglucinol; Phytochemicals; Plant Extracts; Plant Proteins; Terpenes | 2020 |
Protective Role of St. John's Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypericum; Inflammation; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2020 |
Targeting the biological activity and biosynthesis of hyperforin: a mini-review.
Topics: Hypericum; Molecular Structure; Phloroglucinol; Terpenes | 2022 |
Hyperforin: A natural lead compound with multiple pharmacological activities.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Hypericum; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes | 2023 |
20 trial(s) available for phloroglucinol and hyperforin
| Article | Year |
|---|---|
Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes; Xanthenes | 1998 |
Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG.
Topics: Adult; Anthracenes; Bridged Bicyclo Compounds; Cerebral Cortex; Electroencephalography; Female; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
Is the antidepressant effect of Hypericum extracts depending on their hyperforin content?
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Double-Blind Method; Germany; Humans; Phloroglucinol; Placebos; Plant Extracts; Plants, Medicinal; Terpenes | 1999 |
Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.
Topics: Adult; Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Cross-Over Studies; Double-Blind Method; Ericales; Humans; Hydrocortisone; Male; Middle Aged; Perylene; Phloroglucinol; Plants, Medicinal; Prolactin; Somatostatin; Terpenes | 1999 |
Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells.
Topics: Adjuvants, Immunologic; Administration, Topical; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Cell Division; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis; Humans; Hypericum; Immunity, Cellular; Immunosuppressive Agents; Isoantigens; Leukocytes, Mononuclear; Phloroglucinol; Plants, Medicinal; Prospective Studies; T-Lymphocytes; Terpenes | 2000 |
Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gelatin; Humans; Hypericum; Male; Mass Spectrometry; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Reference Values; Terpenes | 2000 |
Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy male volunteers.
Topics: Adult; Antidepressive Agents; Blood Pressure; Bridged Bicyclo Compounds; Dopamine; Heart Rate; Human Growth Hormone; Humans; Hydrocortisone; Hypericum; Male; Neurosecretory Systems; Norepinephrine; Phloroglucinol; Plant Extracts; Prolactin; Serotonin; Terpenes | 2001 |
Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.
Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Bridged Bicyclo Compounds; Corticosterone; Cross-Over Studies; Double-Blind Method; Humans; Hypericum; Ketanserin; Male; Middle Aged; Neurosecretory Systems; Perylene; Phloroglucinol; Piperazines; Plant Extracts; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Terpenes | 2001 |
[Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Child; Colony Count, Microbial; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Ointments; Phloroglucinol; Phytotherapy; Plant Extracts; Prospective Studies; Staphylococcal Skin Infections; Staphylococcus aureus; Terpenes | 2003 |
Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.
Topics: Adult; Antidepressive Agents; Area Under Curve; Bridged Bicyclo Compounds; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Humans; Hypericum; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2004 |
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.
Topics: Adolescent; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.
Topics: Adult; Biomarkers; Bridged Bicyclo Compounds; Chi-Square Distribution; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; National Institutes of Health (U.S.); Patient Compliance; Phloroglucinol; Statistics, Nonparametric; Terpenes; United States | 2005 |
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.
Topics: Adult; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Extracts; Tablets; Terpenes | 2006 |
Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.
Topics: Aged; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Statistics, Nonparametric; Terpenes; Treatment Outcome | 2008 |
No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.
Topics: Administration, Oral; Adult; Bridged Bicyclo Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Male; Midazolam; Phloroglucinol; Plant Preparations; Powders; Substrate Specificity; Terpenes; Young Adult | 2009 |
In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo.
Topics: Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Antioxidants; Double-Blind Method; Erythema; Female; Free Radical Scavengers; Humans; Hypericum; Inflammation; Keratinocytes; Male; Middle Aged; Phloroglucinol; Plant Extracts; Skin; Swine; Terpenes; Ultraviolet Rays; Young Adult | 2012 |
Radical protection in the visible and infrared by a hyperforin-rich cream--in vivo versus ex vivo methods.
Topics: Administration, Topical; Adult; Animals; Antioxidants; Double-Blind Method; Electron Spin Resonance Spectroscopy; Female; Humans; Hypericum; Infrared Rays; Light; Male; Phloroglucinol; Placebos; Skin Cream; Swine; Terpenes; Young Adult | 2013 |
No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.
Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Hypericum; Male; Phloroglucinol; Plant Extracts; Psychotropic Drugs; Terpenes | 2019 |
298 other study(ies) available for phloroglucinol and hyperforin
| Article | Year |
|---|---|
[Structure of the chromophoric part of hyperforin].
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Diterpenes; Phloroglucinol; Plant Extracts; Terpenes | 1975 |
[Structure of the antibiotic hyperforin].
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Diterpenes; Phloroglucinol; Terpenes | 1976 |
[Therapy of mild to medium degree depression].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plant Oils; Severity of Illness Index; Terpenes | 1998 |
Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L.
Topics: Bridged Bicyclo Compounds; Magnetic Resonance Spectroscopy; Phloroglucinol; Plant Extracts; Plants, Medicinal; Spectrophotometry; Terpenes | 1998 |
Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Hypericum; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Terpenes; Xanthenes | 1998 |
Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Dopamine; Female; Hypericum; Male; Mice; Monoamine Oxidase; Neurotransmitter Uptake Inhibitors; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Synaptosomes; Terpenes; Xanthenes | 1998 |
Activity profiles of two hyperforin-containing hypericum extracts in behavioral models.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds; Hypericum; Male; Mice; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Stereotyped Behavior; Terpenes; Xanthenes | 1998 |
Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
Topics: Animals; Brain; Bridged Bicyclo Compounds; Carbon Dioxide; Electrodes, Implanted; Electroencephalography; Hypericum; Male; Methanol; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Terpenes; Xanthenes | 1998 |
Hyperforin as a possible antidepressant component of hypericum extracts.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Helplessness, Learned; Hypericum; Male; Models, Chemical; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Synaptosomes; Terpenes; Xanthenes | 1998 |
Oxidation products of hyperforin from Hypericum perforatum.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Ericales; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Phloroglucinol; Plant Extracts; Terpenes | 1998 |
Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L.
Topics: Bridged Bicyclo Compounds; Drug Stability; Drug Storage; Ericales; Phloroglucinol; Plants, Medicinal; Temperature; Terpenes; Time Factors | 1999 |
Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Catecholamines; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hydroxyindoleacetic Acid; Kinetics; Locus Coeruleus; Male; Norepinephrine; Phloroglucinol; Rats; Rats, Sprague-Dawley; Serotonin; Terpenes | 1999 |
Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria.
Topics: Anti-Bacterial Agents; Bacterial Infections; Bridged Bicyclo Compounds; Drug Resistance, Microbial; Ericales; Gram-Positive Bacteria; Humans; Phloroglucinol; Phytotherapy; Plant Extracts; Staphylococcal Infections; Staphylococcus aureus; Terpenes | 1999 |
Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.
Topics: Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Ericales; Female; Humans; Intracellular Fluid; Kinetics; Mice; Paroxetine; Phloroglucinol; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Serotonin; Sodium; Synaptosomes; Terpenes; Tritium | 1999 |
Antibacterial activity of hyperforin from St John's wort.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Drug Resistance, Multiple; Ericales; Humans; Phloroglucinol; Staphylococcal Infections; Staphylococcus aureus; Terpenes | 1999 |
Antibacterial activity of hyperforin from St John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Ericales; Humans; Perylene; Phloroglucinol; Terpenes | 1999 |
Antibacterial activity of hyperforin from St John's wort.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Drug Resistance, Multiple; Ericales; Humans; Phloroglucinol; Staphylococcal Infections; Staphylococcus aureus; Terpenes | 1999 |
Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cell Membrane; Dose-Response Relationship, Drug; Electric Conductivity; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Phloroglucinol; Purkinje Cells; Pyramidal Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Terpenes | 1999 |
Measurement of hyperforin a constituent of St. John's wort in plasma by high-performance liquid chromatography.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Hypericum; Male; Phloroglucinol; Plants, Medicinal; Rats; Reproducibility of Results; Spectrophotometry, Ultraviolet; Terpenes | 1999 |
Hyperforin analogues from St. John's wort (Hypericum perforatum).
Topics: Bridged Bicyclo Compounds; Hypericum; Molecular Structure; Phloroglucinol; Plants, Medicinal; Spectrum Analysis; Terpenes | 2000 |
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
Topics: Bridged Bicyclo Compounds; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypericum; Ligands; Liver; Mixed Function Oxygenases; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Terpenes | 2000 |
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes | 2000 |
Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways.
Topics: Animals; Biological Transport; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Ionophores; Mice; Mice, Inbred Strains; Monensin; Neurotransmitter Uptake Inhibitors; Ouabain; Phloroglucinol; Plants, Medicinal; Sodium Channels; Synaptosomes; Terpenes | 2000 |
St. John's Wort: is it effective and harmless?
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 1999 |
Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons.
Topics: Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Calcium Channel Blockers; Calcium Channels, P-Type; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hypericum; Ion Channel Gating; Membrane Potentials; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phloroglucinol; Plants, Medicinal; Purkinje Cells; Rats; Rats, Wistar; Second Messenger Systems; Terpenes; Thionucleotides | 2000 |
St John's wort, a herbal antidepressant, activates the steroid X receptor.
Topics: Animals; Anthracenes; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Bridged Bicyclo Compounds; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Histone Acetyltransferases; Humans; Hypericum; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Perylene; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Protein Binding; Receptors, Steroid; Rifampin; Terpenes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Hyperforin in extracts of St John's wort (Hypericum perforatum) for depression.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plants, Medicinal; Terpenes | 2000 |
Three new hyperforin analogues from Hypericum perforatum.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phloroglucinol; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Terpenes | 2001 |
Pharmacology. How the body's 'garbage disposal' may inactivate drugs.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bridged Bicyclo Compounds; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hypericum; Liver; Mice; Mice, Knockout; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Terpenes; Transcription Factors; Xenobiotics | 2001 |
Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Molecular Structure; Phloroglucinol; Plants, Medicinal; Terpenes | 2000 |
Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Chromatography, Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Hypericum; In Vitro Techniques; Male; Norepinephrine; Phloroglucinol; Plants, Medicinal; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
St John's Wort and literature quotations.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Bridged Bicyclo Compounds; Depression; Dopamine; Drug Interactions; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plants, Medicinal; Serotonin; Terpenes; Treatment Outcome | 2001 |
Effect of St. John's wort on free radical production.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Free Radicals; Humans; Hypericum; Indicators and Reagents; Perylene; Phloroglucinol; Placenta; Plant Extracts; Plants, Medicinal; Pregnancy; Superoxides; Terpenes; Veins | 2001 |
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes | 2001 |
Stimulation of glutamate, aspartate and gamma-aminobutyric acid release from synaptosomes by hyperforin.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Aspartic Acid; Bridged Bicyclo Compounds; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Hydrogen-Ion Concentration; Male; Neurotransmitter Agents; Phloroglucinol; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reserpine; Synaptosomes; Terpenes; Veratridine | 2001 |
Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; Hypericum; Imipramine; Male; Methanol; Microdialysis; Neurons; Nucleus Accumbens; Phloroglucinol; Plant Extracts; Rats; Rats, Inbred Strains; Serotonin; Solvents; Terpenes | 2001 |
In vitro effects of St. John's wort extract and hyperforin on 5 HT uptake and efflux in human blood platelets.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Blood Platelets; Bridged Bicyclo Compounds; Cyclohexanols; Humans; Hypericum; In Vitro Techniques; Phloroglucinol; Plant Extracts; Reserpine; Serotonin; Terpenes; Venlafaxine Hydrochloride | 2001 |
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Male; Neurotransmitter Agents; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
Batch-to-batch reproducibility of St. John's wort preparations.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Reproducibility of Results; Terpenes | 2001 |
Effects of hyperforin on the fluidity of brain membranes.
Topics: Animals; Anisotropy; Antidepressive Agents; Bridged Bicyclo Compounds; Diphenylhexatriene; Female; Fluorescent Dyes; Guinea Pigs; Membrane Fluidity; Neurons; Phloroglucinol; Terpenes | 2001 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Chronic Disease; Depression; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electroshock; Fluoxetine; Hypericum; Imipramine; Microdialysis; Phloroglucinol; Plant Extracts; Rats; Stress, Physiological; Terpenes | 2001 |
In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.
Topics: Animals; Anthracenes; Antidepressive Agents; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Flavonoids; Hypericum; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Perylene; Phloroglucinol; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neuropeptide Y; Receptors, Serotonin; Receptors, sigma; Terpenes | 2001 |
Hypericum extract and hyperforin: memory-enhancing properties in rodents.
Topics: Amnesia; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bridged Bicyclo Compounds; Hypericum; Male; Memory; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Scopolamine; Terpenes | 2001 |
Hyperforin stimulates intracellular calcium mobilisation and enhances extracellular acidification in DDT1-MF2 smooth muscle cells.
Topics: Acids; Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Calcium; Chelating Agents; Cricetinae; Egtazic Acid; Extracellular Space; Fluorescent Dyes; Fura-2; Male; Mesocricetus; Muscle, Smooth; Phloroglucinol; Terpenes; Vas Deferens | 2001 |
Interleukin-6 involvement in antidepressant action of Hypericum perforatum.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Diencephalon; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Hypericum; Immune System; Interleukin-6; Male; Mice; Mice, Knockout; Perylene; Phloroglucinol; Plant Extracts; Rutin; Serotonin; Swimming; Terpenes; Tryptophan | 2001 |
Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antidepressive Agents; Bicuculline; Bridged Bicyclo Compounds; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Guinea Pigs; Hippocampus; Hypericum; Organ Culture Techniques; Phloroglucinol; Plant Extracts; Terpenes | 2001 |
Hyperforin--antidepressant activity by a novel mechanism of action.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Bridged Bicyclo Compounds; Hydrogen-Ion Concentration; Hypericum; Mice; Phloroglucinol; Plant Extracts; Serotonin; Sodium; Sodium Channels; Sodium-Hydrogen Exchangers; Synaptosomes; Terpenes; Tritium | 2001 |
High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2001 |
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Solutions; Terpenes | 2001 |
Chemical and pharmacological evaluation of Hypericum perforatum extracts.
Topics: Animals; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Free Radical Scavengers; Hippocampus; Hypericum; Male; Perylene; Phloroglucinol; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Terpenes | 2000 |
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Electrolytes; Electrophoresis, Capillary; Hypericum; Molecular Structure; Osmotic Pressure; Perylene; Phloroglucinol; Plant Extracts; Reproducibility of Results; Rheology; Solvents; Terpenes | 2002 |
Is St John's wort a 'Prozac-like' herbal antidepressant?
Topics: Animals; Bridged Bicyclo Compounds; Fluoxetine; Humans; Hypericum; Phloroglucinol; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Terpenes | 2001 |
Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Terpenes | 2001 |
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Caspases; Cell Division; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Hypericum; Intracellular Membranes; Microscopy, Electron; Mitochondria; Neoplasms; Phloroglucinol; Rats; Staurosporine; Terpenes; Time Factors; Tumor Cells, Cultured | 2002 |
Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.
Topics: Alanine Transaminase; Animals; Anthracenes; Antidepressive Agents; Body Weight; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Hypericum; Isoenzymes; Liver; Male; Mice; Perylene; Phloroglucinol; Plant Preparations; Terpenes | 2002 |
Determining hyperforin and hypericin content in eight brands of St. John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dosage Forms; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2002 |
Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort.
Topics: Acetylcholine; Animals; Anti-Bacterial Agents; Biological Transport; Bridged Bicyclo Compounds; Choline; Corpus Striatum; Hypericum; Motor Activity; Phloroglucinol; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Terpenes | 2002 |
Regulating natural health products.
Topics: Bridged Bicyclo Compounds; Drug Interactions; Drug Labeling; Humans; Hypericum; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; United States | 2002 |
Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Chromatography, Thin Layer; Cyclohexanes; Dopamine Antagonists; Hypericum; Inhibitory Concentration 50; Molecular Conformation; Phloroglucinol; Plants, Medicinal; Rats; Receptors, Neurotransmitter; Selective Serotonin Reuptake Inhibitors; Spectrophotometry, Infrared; Structure-Activity Relationship; Terpenes | 2002 |
A preliminary approach to nonenolizable beta,beta-tricarbonyls: assembly of a hyperevolutin prototype.
Topics: Adamantane; Biological Factors; Bridged Bicyclo Compounds; Catalysis; Clusiaceae; Crystallography, X-Ray; Cyclization; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plants, Medicinal; Stereoisomerism; Terpenes | 2002 |
Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy.
Topics: Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Multivariate Analysis; Phloroglucinol; Plant Extracts; Reference Standards; Spectrophotometry, Ultraviolet; Spectroscopy, Near-Infrared; Terpenes | 2002 |
Antidepressant activity of hyperforin conjugates of the St. John's wort, Hypericum perforatum Linn.: an experimental study.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Female; Hypericum; Male; Phloroglucinol; Plant Extracts; Rats; Swimming; Terpenes | 2001 |
Inhibition of vesicular uptake of monoamines by hyperforin.
Topics: Animals; Anti-Bacterial Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Fluoxetine; Hypericum; Male; Neurotransmitter Uptake Inhibitors; Phloroglucinol; Piperazines; Plant Extracts; Prosencephalon; Rats; Synaptosomes; Terpenes | 2002 |
Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.
Topics: Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Reproducibility of Results; Terpenes | 2002 |
The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Bridged Bicyclo Compounds; Calcium; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Phloroglucinol; Potassium Channel Blockers; Potassium Channels; Sodium; Sodium Channel Blockers; Sodium Channels; Terpenes; Tetrodotoxin; Veratridine | 2002 |
Biosynthesis of hyperforin in Hypericum perforatum.
Topics: Bridged Bicyclo Compounds; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Terpenes | 2002 |
Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Humans; Male; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Terpenes | 2002 |
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.
Topics: Anti-Bacterial Agents; Arachidonate 5-Lipoxygenase; Blood Platelets; Bridged Bicyclo Compounds; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Inhibitors; Humans; Hypericum; Isoenzymes; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Membrane Proteins; Phloroglucinol; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Terpenes | 2002 |
Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts.
Topics: Animals; Antidepressive Agents; Arousal; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Cyclohexylamines; Dose-Response Relationship, Drug; Exploratory Behavior; Hypericum; Male; Motor Activity; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Terpenes | 2002 |
Pharmacological activity of hyperforin acetate in rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Bridged Bicyclo Compounds; Helplessness, Learned; Hypnotics and Sedatives; Imipramine; Male; Motor Activity; Muscle Relaxants, Central; Pentobarbital; Phloroglucinol; Rats; Rats, Sprague-Dawley; Sleep; Swimming; Terpenes; Time Factors | 2002 |
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).
Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2002 |
Antagonist effect of pseudohypericin at CRF1 receptors.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Calcitonin; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Perylene; Phloroglucinol; Receptors, Corticotropin-Releasing Hormone; Terpenes; Transfection | 2003 |
Biorelevant dissolution testing of St John's wort products.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Ethanol; Hypericum; Kinetics; Methanol; Phloroglucinol; Plant Extracts; Quercetin; Reproducibility of Results; Rutin; Solubility; Solvents; Terpenes; Time Factors | 2002 |
[Dangerous interaction of St. John's wort with chemotherapy?].
Topics: Anthracenes; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Terpenes | 2003 |
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.
Topics: Animals; Antidepressive Agents; Binding Sites; Biopolymers; Bridged Bicyclo Compounds; Cell Line; Cells, Cultured; Chlorocebus aethiops; Computer Simulation; Crystallization; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Humans; Hypericum; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Phloroglucinol; Pregnane X Receptor; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Structure-Activity Relationship; Terpenes; Transfection | 2003 |
Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.
Topics: Arachidonate 5-Lipoxygenase; Arsenites; Benzeneacetamides; Bridged Bicyclo Compounds; Calcimycin; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Hydroxamic Acids; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; Mutation, Missense; Neutrophils; Peroxides; Phloroglucinol; Phosphorylation; Pyrans; Quinolines; Quinolones; Sodium Chloride; Sodium Compounds; Terpenes | 2003 |
Treatment with Hypericum perforatum L. does not trigger decreased resistance in Staphylococcus aureus against antibiotics and hyperforin.
Topics: Bridged Bicyclo Compounds; Drug Resistance, Bacterial; Hypericum; Microbial Sensitivity Tests; Penicillins; Phloroglucinol; Plant Extracts; Staphylococcus aureus; Terpenes | 2003 |
Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane.
Topics: Adenosine Triphosphate; Amines; Animals; Anti-Bacterial Agents; Biological Transport; Bridged Bicyclo Compounds; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Ionophores; Phloroglucinol; Protons; Rats; Synaptic Membranes; Synaptic Vesicles; Terpenes; Time Factors | 2003 |
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Female; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phloroglucinol; Physical Exertion; Plant Extracts; Rats; Rats, Inbred Strains; Swimming; Terpenes | 2003 |
Further degradation product of hyperforin from Hypericum perforatum (St John's Wort).
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacillus subtilis; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Candida albicans; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Hypericum; Microbial Sensitivity Tests; Phloroglucinol; Phytotherapy; Plant Extracts; Staphylococcus aureus; Terpenes | 2003 |
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Topics: Annexin A5; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Astrocytes; Biflavonoids; Bridged Bicyclo Compounds; Caspases; Catechin; Cell Division; Cell Line, Tumor; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Proanthocyanidins; Terpenes | 2003 |
Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse.
Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phloroglucinol; Plant Extracts; Terpenes; Time Factors | 2003 |
Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Antidepressive Agents; Body Weight; Brain; Bridged Bicyclo Compounds; Corticosterone; Drug Interactions; Hypericum; Hypothalamo-Hypophyseal System; Immunohistochemistry; In Situ Hybridization; Male; Organ Size; Phloroglucinol; Phosphoproteins; Pituitary-Adrenal System; Plant Extracts; Pro-Opiomelanocortin; Radioimmunoassay; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Terpenes; Time Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2003 |
Comparison of the growth-inhibitory effect of Hypericum perforatum L. extracts, differing in the concentration of phloroglucinols and flavonoids, on leukaemia cells.
Topics: Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Cell Division; Chromatography, High Pressure Liquid; Flavonoids; Humans; Hypericum; Inhibitory Concentration 50; K562 Cells; Light; Phloroglucinol; Plant Extracts; Terpenes; U937 Cells | 2003 |
Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone and Bones; Bone Density; Bridged Bicyclo Compounds; COS Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression; Glycoproteins; HeLa Cells; Homeostasis; Humans; Mice; Mice, Knockout; Osteoblasts; Osteocalcin; Osteopontin; Osteoprotegerin; Osteosarcoma; Phloroglucinol; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sialoglycoproteins; Terpenes; Transfection; Tumor Cells, Cultured; Vitamin K 2 | 2003 |
A simple and reliable semipreparative high-performance liquid chromatography technique for the isolation of marker-grade hyperforin from Hypericum perforatum L extract.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Mass Spectrometry; Phloroglucinol; Plant Extracts; Reproducibility of Results; Terpenes | 2003 |
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.
Topics: Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Binding Sites; Bridged Bicyclo Compounds; Cytochrome P-450 CYP2C9; Enzyme Induction; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Humans; Phenobarbital; Phloroglucinol; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Terpenes; Transcriptional Activation; Tumor Cells, Cultured | 2004 |
Enhancement of proteolytic processing of the beta-amyloid precursor protein by hyperforin.
Topics: Amyloid beta-Protein Precursor; Animals; Bridged Bicyclo Compounds; Endopeptidases; Humans; Hydrolysis; PC12 Cells; Phloroglucinol; Rats; Terpenes | 2003 |
Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry.
Topics: Administration, Oral; Animals; Body Weight; Brain Chemistry; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Mice; Molecular Structure; Phloroglucinol; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2003 |
A new synthetic approach to the polycyclic polyprenylated acylphloroglucinols.
Topics: Alkynes; Benzophenones; Bridged Bicyclo Compounds; Cyclization; Molecular Structure; Phloroglucinol; Terpenes | 2003 |
Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Hypericum; Imipramine; Male; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Stress, Psychological; Terpenes | 2003 |
Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex.
Topics: Animals; Anthracenes; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Cell Membrane; Fluoxetine; Frontal Lobe; Hypericum; Imipramine; Male; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Terpenes | 2004 |
In vitro metabolism of hyperforin in rat liver microsomal systems.
Topics: Animals; Anti-Bacterial Agents; Biotransformation; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dexamethasone; Female; Hydroxylation; Hypnotics and Sedatives; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; NAD; Phenobarbital; Phloroglucinol; Rats; Rats, Sprague-Dawley; Terpenes | 2004 |
Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Stability; Ethanol; Hypericum; Male; Mice; Mice, Inbred C57BL; Phloroglucinol; Phytotherapy; Plant Extracts; Plant Structures; Terpenes; Time Factors | 2003 |
Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores.
Topics: Adaptation, Physiological; Animals; Anthracenes; Anti-Bacterial Agents; Biological Assay; Bridged Bicyclo Compounds; Coleoptera; Enzyme Inhibitors; Feeding Behavior; Hypericum; Larva; Moths; Perylene; Phloroglucinol; Plants, Edible; Terpenes | 2003 |
Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Flow Cytometry; Genes, MDR; Herb-Drug Interactions; Humans; Hypericum; Mice; NIH 3T3 Cells; Perylene; Phloroglucinol; Terpenes | 2004 |
Enrichment of hyperforin from St. John's wort (Hypericum perforatum) by pilot-scale supercritical carbon dioxide extraction.
Topics: Bridged Bicyclo Compounds; Calibration; Carbon Dioxide; Chromatography, Supercritical Fluid; Hypericum; Phloroglucinol; Plant Extracts; Pressure; Temperature; Terpenes | 2004 |
Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin.
Topics: Anti-Bacterial Agents; Bridged Bicyclo Compounds; Calcium; Estrenes; GTP-Binding Proteins; Humans; In Vitro Techniques; Leukocyte Elastase; Leukocytes; Neutrophils; Phloroglucinol; Pyrrolidinones; Reactive Oxygen Species; Terpenes; Type C Phospholipases | 2004 |
Proteome analysis reveals a distinct molecular profile of cellular stress following incubation of DDT1-MF2 smooth muscle cells in the presence of a high concentration of hyperforin.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Cricetinae; Electrophoresis, Gel, Two-Dimensional; Hypericum; Male; Mesocricetus; Muscle, Smooth; Phloroglucinol; Phytotherapy; Plant Extracts; Proteome; Stress, Physiological; Terpenes; Vas Deferens | 2004 |
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
Topics: Bridged Bicyclo Compounds; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Humans; Hypericum; Phloroglucinol; RNA, Messenger; Terpenes | 2004 |
Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort.
Topics: Acetylcholine; Anesthetics, Local; Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Hippocampus; Hypericum; Microdialysis; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; Terpenes; Tetrodotoxin | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Development of a high-performance liquid chromatographic method with electrochemical detection for the determination of hyperforin.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Electrochemistry; Hypericum; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Terpenes | 2004 |
In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cyclohexylamines; Female; Humans; Hypericum; Inhibitory Concentration 50; Interleukin-6; Male; Models, Animal; Models, Biological; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Inbred Strains; Terpenes | 2004 |
Hyperforin modifies neuronal membrane properties in vivo.
Topics: Administration, Oral; Animals; Anisotropy; Brain; Brain Chemistry; Bridged Bicyclo Compounds; Cell Membrane; Chromatography, Liquid; Diphenylhexatriene; Dose-Response Relationship, Drug; Female; Hypericum; Membrane Fluidity; Mice; Neurons; Phloroglucinol; Plant Extracts; Pyrenes; Terpenes | 2004 |
Hyperforin inhibits cancer invasion and metastasis.
Topics: Adenocarcinoma; Animals; Apoptosis; Bridged Bicyclo Compounds; Cell Division; Cell Survival; Colonic Neoplasms; Cyclohexylamines; Enzyme Activation; Fibrosarcoma; Gelatinases; Humans; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Phloroglucinol; Quaternary Ammonium Compounds; Serine Endopeptidases; Terpenes | 2004 |
Undeclared exposure to St. John's Wort in hospitalized patients.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Bridged Bicyclo Compounds; Drug Interactions; Hospitalization; Humans; Hypericum; Middle Aged; Perylene; Phloroglucinol; Self Medication; Substance Abuse Detection; Terpenes | 2004 |
Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage.
Topics: Beverages; Bridged Bicyclo Compounds; Drug Stability; Hydrogen-Ion Concentration; Hypericum; Molecular Structure; Phloroglucinol; Solutions; Terpenes; Water | 2004 |
Hyperforin depletes synaptic vesicles content and induces compartmental redistribution of nerve ending monoamines.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Biological Transport; Brain; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Neurotransmitter Uptake Inhibitors; Phloroglucinol; Rats; Serotonin; Synaptic Vesicles; Terpenes; Time Factors; Tritium | 2004 |
Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin.
Topics: Bridged Bicyclo Compounds; Horseradish Peroxidase; Hydrogen Peroxide; Hypericum; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovalbumin; Oxidation-Reduction; Phloroglucinol; Proteins; Serum Albumin; Terpenes | 2004 |
Air/light-free hyphenated extraction/analysis system: supercritical fluid extraction on-line coupled with liquid chromatography-UV absorbance/electrospray mass spectrometry for the determination of hyperforin and its degradation products in Hypericum pert
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Hypericum; Light; Oxygen; Phloroglucinol; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2004 |
Modulation of P-glycoprotein function by St John's wort extract and its major constituents.
Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Bridged Bicyclo Compounds; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Fluoresceins; Fluoxetine; Herb-Drug Interactions; Humans; Hypericum; Leukemia; Models, Biological; Phloroglucinol; Plant Extracts; Quercetin; Swine; Terpenes | 2004 |
Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.
Topics: Aged; Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2004 |
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Stability; Phloroglucinol; Rats; Solubility; Terpenes | 2005 |
Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Cell Line; Gene Expression Regulation; Humans; Hypericum; Inflammation Mediators; Interleukin-8; Intestinal Mucosa; Mitogen-Activated Protein Kinases; NF-kappa B; Phloroglucinol; Phytotherapy; Signal Transduction; Terpenes; Transcription Factor AP-1 | 2004 |
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bridged Bicyclo Compounds; Cell Line, Tumor; Colonic Neoplasms; Digoxin; Humans; Hypericum; LLC-PK1 Cells; Perylene; Phloroglucinol; Plant Extracts; Rifampin; Swine; Terpenes; Transfection | 2005 |
The first prenylation step in hyperforin biosynthesis.
Topics: Bridged Bicyclo Compounds; Dimethylallyltranstransferase; Hydrogen-Ion Concentration; Hypericum; Iron; Molecular Structure; Phloroglucinol; Protein Prenylation; Solubility; Substrate Specificity; Temperature; Terpenes | 2005 |
Biosynthesis of the hyperforin skeleton in Hypericum calycinum cell cultures.
Topics: Acyltransferases; Bridged Bicyclo Compounds; Carbon-Carbon Ligases; Cells, Cultured; Hypericum; Molecular Structure; Phloroglucinol; Polyketide Synthases; Terpenes; Time Factors | 2005 |
High-performance liquid chromatography measurement of hyperforin and its reduced derivatives in rodent plasma.
Topics: Animals; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Drug Stability; Male; Mice; Oxidation-Reduction; Phloroglucinol; Rats; Terpenes | 2005 |
Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Esters; Hypericum; Immobilization; Male; Phloroglucinol; Plant Extracts; Protein Binding; Rats; Stress, Physiological; Terpenes | 2005 |
Hyperforin activates nonselective cation channels (NSCCs).
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Cell Line; Humans; Ion Channels; Phloroglucinol; Selective Serotonin Reuptake Inhibitors; Serotonin; Sodium-Calcium Exchanger; Terpenes | 2005 |
Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ejaculation; Humans; Hypericum; Isometric Contraction; Male; Muscle, Smooth; Orgasm; Perylene; Phloroglucinol; Rats; Terpenes; Tissue Culture Techniques; Vas Deferens | 2005 |
Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems.
Topics: Bridged Bicyclo Compounds; Crystallography, X-Ray; Hypericum; Ketones; Models, Chemical; Models, Molecular; Molecular Conformation; Phloroglucinol; Stereoisomerism; Terpenes | 2005 |
Hyperforin, a bio-active compound of St. John's Wort, is a new inhibitor of angiogenesis targeting several key steps of the process.
Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Bridged Bicyclo Compounds; Cattle; Cell Division; Cell Line, Tumor; Cells, Cultured; Endothelium, Vascular; Extracellular Matrix; Humans; Hypericum; Mice; Neovascularization, Physiologic; Phloroglucinol; Terpenes | 2005 |
Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drinking; Eating; Hypericum; Injections, Intraperitoneal; Male; Naltrexone; Narcotic Antagonists; Phloroglucinol; Plant Extracts; Rats; Terpenes; Time Factors; Treatment Outcome | 2005 |
Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.
Topics: Aged; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Bridged Bicyclo Compounds; Chromatography, Liquid; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Docetaxel; Drug Synergism; Female; Hepatocytes; Humans; Hypericum; Ions; Liver; Mass Spectrometry; Middle Aged; Models, Chemical; Phloroglucinol; Rifampin; Taxoids; Terpenes; Time Factors | 2005 |
St. John's wort and its constituent hyperforin concordantly regulate expression of genes encoding enzymes involved in basic cellular pathways.
Topics: Base Sequence; Bridged Bicyclo Compounds; Calcium; Cell Hypoxia; Cell Line; Cholesterol; Gene Expression Regulation, Enzymologic; Glucose; Glycolysis; Humans; Hypericum; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Phloroglucinol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; Xenobiotics | 2005 |
Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Osmolar Concentration; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Hyperforin acts as an angiogenesis inhibitor.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Cell Line, Tumor; Cell Proliferation; Endothelial Cells; Endothelium, Vascular; Female; Humans; Phloroglucinol; Rats; Rats, Wistar; Terpenes | 2005 |
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
Topics: Animals; Anthracenes; Biflavonoids; Bridged Bicyclo Compounds; Carrier Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Fluoxetine; Fluvoxamine; Food; Hypericum; Ligands; Macrophages; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Osteoclasts; Perylene; Phloroglucinol; Plant Extracts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Serotonin; Stress, Physiological; Terpenes; Time Factors | 2005 |
Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia.
Topics: Apoptosis; Blotting, Western; Bridged Bicyclo Compounds; Caspases; Cyclin-Dependent Kinase Inhibitor p27; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Nitric Oxide; Nitric Oxide Synthase Type II; Phloroglucinol; Terpenes | 2006 |
Hyperforin inhibits MMP-9 secretion by B-CLL cells and microtubule formation by endothelial cells.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Bone Marrow Cells; Bridged Bicyclo Compounds; Cell Line; Cells, Cultured; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; Female; Gelatinases; Humans; In Vitro Techniques; Leukemia, B-Cell; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Microtubules; Middle Aged; Phloroglucinol; Terpenes; Vascular Endothelial Growth Factors | 2006 |
St. John's wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 mothers and 2 infants.
Topics: Adult; Breast Feeding; Bridged Bicyclo Compounds; Depressive Disorder; Female; Humans; Hypericum; Infant; Mass Spectrometry; Maternal Exposure; Maternal-Fetal Exchange; Milk, Human; Phloroglucinol; Phytotherapy; Plant Preparations; Pregnancy; Terpenes | 2006 |
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Sonication; Terpenes | 2006 |
Evaluation of hyperforin analogues for inhibition of 5-lipoxygenase.
Topics: Bridged Bicyclo Compounds; Cells, Cultured; Enzyme Inhibitors; Humans; Hypericum; Lipoxygenase Inhibitors; Neutrophils; Phloroglucinol; Terpenes | 2005 |
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Analysis of Variance; Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Escape Reaction; Hippocampus; Hypericum; Male; Maze Learning; Microinjections; Neuroprotective Agents; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Terpenes; Time Factors | 2006 |
Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin.
Topics: Bridged Bicyclo Compounds; Hypericum; Molecular Structure; Phloroglucinol; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Terpenes | 2006 |
NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.
Topics: Animals; Brain Edema; Brain Ischemia; Bridged Bicyclo Compounds; Calcium; Choline; Hippocampus; Hypericum; In Vitro Techniques; Male; Microscopy, Fluorescence; Neuroprotective Agents; Phloroglucinol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Terpenes; Water Intoxication | 2006 |
Hyperforin.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Hypericum; Neurotransmitter Uptake Inhibitors; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Terpenes | 2006 |
Hyperforin and its analogues inhibit CYP3A4 enzyme activity.
Topics: Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hypericum; Molecular Structure; Phloroglucinol; Terpenes | 2006 |
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study.
Topics: Animals; Antimalarials; Bridged Bicyclo Compounds; Cell Line, Tumor; Erythrocytes; Humans; Magnetic Resonance Spectroscopy; Myoblasts; Phloroglucinol; Plasmodium falciparum; Rats; Structure-Activity Relationship; Terpenes | 2007 |
Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Movement; Chemotaxis, Leukocyte; Cyclohexylamines; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Inflammation; Male; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Neutrophils; Phloroglucinol; Pulmonary Fibrosis; Terpenes | 2007 |
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes | 2007 |
Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum.
Topics: Amino Acids; Bridged Bicyclo Compounds; Carbon Isotopes; Cells, Cultured; Chromatography, High Pressure Liquid; Hypericum; Isoleucine; Leucine; Molecular Structure; Phloroglucinol; Plant Shoots; Tandem Mass Spectrometry; Terpenes; Threonine; Valine | 2007 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins | 2007 |
Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy.
Topics: Animals; Brain Neoplasms; Bridged Bicyclo Compounds; Cell Line, Tumor; Cyclic AMP; Glioblastoma; Humans; Phloroglucinol; Protein Binding; Quercetin; Rats; Receptors, Adrenergic, beta-2; Spectrometry, Fluorescence; Terpenes | 2007 |
Hyperforin accumulates in the translucent glands of Hypericum perforatum.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Molecular Structure; Phloroglucinol; Plant Leaves; Plants, Medicinal; Spectrophotometry, Ultraviolet; Terpenes | 2007 |
Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2.
Topics: Bridged Bicyclo Compounds; Cell Proliferation; Cells, Cultured; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Sirtuin 1; Sirtuin 2; Sirtuins; Terpenes | 2007 |
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Tablets; Terpenes; Transcription Factors; Transfection; Tumor Cells, Cultured | 2007 |
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
Topics: Acetates; Agrobacterium tumefaciens; Anthracenes; Bridged Bicyclo Compounds; Cyclopentanes; Hypericum; Oxylipins; Perylene; Phloroglucinol; Polyethylene Glycols; Seeds; Sucrose; Terpenes | 2007 |
Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures.
Topics: Bridged Bicyclo Compounds; Cells, Cultured; Gas Chromatography-Mass Spectrometry; Hypericum; Magnetic Resonance Spectroscopy; Molecular Structure; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Terpenes; Tissue Culture Techniques | 2007 |
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cell Line; Depression; Gene Expression Regulation; Humans; Hypericum; PC12 Cells; Phloroglucinol; Plant Extracts; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Terpenes; TRPC Cation Channels | 2007 |
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Dinoprostone; Flavonoids; Hypericum; Light; Macrophages; Mice; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2007 |
Hyperforin modulation of drug resistance: saint or sinner?
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bridged Bicyclo Compounds; Drug Resistance, Multiple; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cells; Neoplasm Proteins; Phloroglucinol; Terpenes | 2007 |
Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bridged Bicyclo Compounds; Cell Survival; Drug Resistance, Multiple; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitoxantrone; Myeloid Cells; Neoplasm Proteins; Phloroglucinol; Terpenes; Tumor Cells, Cultured | 2007 |
Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease.
Topics: Animals; Bridged Bicyclo Compounds; Cell Survival; Disease Models, Animal; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; GATA3 Transcription Factor; Humans; Interferon-gamma; Interleukin-2; Phloroglucinol; Phytohemagglutinins; Rats; Rats, Inbred Lew; Receptors, CXCR3; T-Box Domain Proteins; T-Lymphocytes; Terpenes; Th1 Cells; Up-Regulation | 2008 |
Variation of hyperforin in Hypericum montbretii during its phenological cycle.
Topics: Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flowers; Hypericum; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Terpenes | 2007 |
Effect of hyperforin-enriched extract on pro-ejaculatory effect of 8-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bridged Bicyclo Compounds; Ejaculation; Electromyography; Hypericum; Male; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Terpenes | 2007 |
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Humans; Hypericum; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Male; NF-kappa B; Nitric Oxide Synthase Type II; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; Terpenes; Tumor Necrosis Factor-alpha | 2008 |
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Roots; Plants, Genetically Modified; Terpenes; Transformation, Genetic | 2008 |
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages.
Topics: Bridged Bicyclo Compounds; Climate; Geography; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Plant Stems; Plant Structures; Population Dynamics; Seasons; Terpenes; Turkey | 2008 |
Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol.
Topics: Antibodies, Monoclonal; Apoptosis; Bridged Bicyclo Compounds; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phloroglucinol; Piperidines; Proto-Oncogene Proteins c-bcl-2; Terpenes; Tumor Cells, Cultured; Up-Regulation | 2009 |
Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation.
Topics: Bridged Bicyclo Compounds; Calcium; Cations; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Humans; Keratinocytes; Models, Biological; Organ Culture Techniques; Phloroglucinol; Skin; Skin Diseases; Terpenes; Time Factors; Transfection; TRPC Cation Channels; TRPC6 Cation Channel | 2008 |
[Examination of different factors influencing the vascularization of human cutaneous melanoma].
Topics: Angiogenesis Inhibitors; Animals; Antigens, CD34; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Female; Humans; Lymphocyte Subsets; Macrophages; Male; Melanoma; Microcirculation; Neovascularization, Pathologic; Phloroglucinol; Rats; Rats, Wistar; Sex Factors; Skin Neoplasms; Terpenes | 2008 |
The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men.
Topics: Adult; Biliary Tract; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Finasteride; Half-Life; Humans; Hypericum; Male; Phloroglucinol; Reference Values; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Terpenes | 2009 |
Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Topics: Aniline Compounds; Animals; Bridged Bicyclo Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Cortex; Cyclohexanones; Diglycerides; Embryo, Mammalian; Enzyme Inhibitors; Fura-2; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phloroglucinol; Potassium Chloride; Second Messenger Systems; Sodium; Terpenes; TRPC Cation Channels; Xanthenes | 2009 |
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.
Topics: Animals; Anthracenes; Apoptosis; Bridged Bicyclo Compounds; DNA Fragmentation; Drugs, Chinese Herbal; Hypericum; Inhibition, Psychological; Male; Mice; Perylene; Phloroglucinol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Reflex, Acoustic; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Terpenes | 2009 |
Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Blotting, Western; Bridged Bicyclo Compounds; Cell Separation; Cells, Cultured; Endothelial Cells; Fluoresceins; Humans; Immunohistochemistry; Myocytes, Smooth Muscle; Phloroglucinol; Pregnane X Receptor; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Swine; Terpenes; Up-Regulation; Xenobiotics | 2009 |
Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in rats.
Topics: Amnesia; Animals; Apoptosis; Bridged Bicyclo Compounds; Central Nervous System Agents; Cerebral Cortex; Cholinergic Antagonists; DNA Fragmentation; Hypericum; Male; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Reflex, Startle; Scopolamine; Sensory Gating; Terpenes | 2009 |
Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.
Topics: Anthracenes; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Female; Haplotypes; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Preparations; Pregnane X Receptor; Receptors, Steroid; Terpenes; Young Adult | 2009 |
Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Cell Movement; Endothelial Cells; Humans; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms; Neovascularization, Pathologic; Phloroglucinol; Terpenes; Xenograft Model Antitumor Assays | 2009 |
Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo.
Topics: Animals; Aorta, Thoracic; Apoptosis; Bridged Bicyclo Compounds; Caspase 3; Caspase 8; Cell Cycle; Cell Proliferation; Cells, Cultured; Cytochromes c; Endothelial Cells; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Lymphangiogenesis; Membrane Potential, Mitochondrial; Mitochondria; Neoplasms, Experimental; Phloroglucinol; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Terpenes; Xenograft Model Antitumor Assays | 2009 |
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Topics: Animals; Arachidonate 5-Lipoxygenase; Binding Sites; Bridged Bicyclo Compounds; Carrageenan; Cells, Cultured; Diglycerides; Humans; Hypericum; Leukotriene B4; Lipoxygenase Inhibitors; Male; MAP Kinase Signaling System; Microfilament Proteins; Neutrophils; Oxidation-Reduction; Phloroglucinol; Phospholipids; Pleurisy; Protein Structure, Tertiary; Protein Transport; Rats; Rats, Wistar; Terpenes; Tryptophan | 2009 |
Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Flavonoids; Flowers; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Reference Standards; Species Specificity; Terpenes | 2010 |
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey | 2009 |
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Topics: Adult; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds; Cell Line; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Female; Gene Expression; Hepatocytes; Humans; Hypericum; Macaca fascicularis; Macaca mulatta; Male; Midazolam; Middle Aged; Models, Animal; Molecular Sequence Data; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Rifampin; Sequence Homology, Amino Acid; Terpenes; Transcriptional Activation; Transfection; Xenobiotics | 2010 |
The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondria; Phloroglucinol; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel; Zinc | 2010 |
The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Bridged Bicyclo Compounds; Disease Models, Animal; Encephalitis; Glial Fibrillary Acidic Protein; Gliosis; Humans; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Oxidative Stress; Phloroglucinol; Terpenes; Tyrosine | 2010 |
Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Calcium Channels; Dose-Response Relationship, Drug; Female; Humans; Mice; Neurites; PC12 Cells; Phloroglucinol; Rats; Terpenes; TRPV Cation Channels | 2010 |
Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions.
Topics: Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds; Calcium; Cytosol; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Magnetic Resonance Spectroscopy; p38 Mitogen-Activated Protein Kinases; Phloroglucinol; Phosphatidylcholines; Phospholipases A2; Phosphorylation; Pyridines; Terpenes | 2010 |
Catalytic asymmetric total synthesis of ent-hyperforin.
Topics: Bridged Bicyclo Compounds; Catalysis; Molecular Structure; Phloroglucinol; Stereoisomerism; Terpenes | 2010 |
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.
Topics: Androstenols; Bridged Bicyclo Compounds; Calcifediol; Cells, Cultured; Cholesterol; Farnesol; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Indoles; Ligands; Phloroglucinol; PPAR gamma; Pregnenediones; Receptors, Cytoplasmic and Nuclear; Selective Estrogen Receptor Modulators; Tamoxifen; Terpenes; Vitamin A | 2010 |
Tetrahydrohyperforin and octahydrohyperforin are two new potent inhibitors of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Bridged Bicyclo Compounds; Carbon; Cattle; Endothelial Cells; Humans; Inhibitory Concentration 50; Mice; Neovascularization, Pathologic; NIH 3T3 Cells; Oxygen; Phloroglucinol; Terpenes | 2010 |
Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages.
Topics: Animals; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Flow Cytometry; Hypericum; Macrophages; Mice; Microglia; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Synthase Type II; Phagocytosis; Phloroglucinol; Plant Extracts; Terpenes | 2010 |
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes | 2010 |
Store-depletion and hyperforin activate distinct types of Ca(2+)-conducting channels in cortical neurons.
Topics: Aniline Compounds; Animals; Bridged Bicyclo Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Cortex; Fluorescent Dyes; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Neurons; Phloroglucinol; Tacrolimus; Terpenes; Thapsigargin; TRPC Cation Channels; Xanthenes | 2010 |
Pharmacological studies on Hypericum perforatum fractions and constituents.
Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypericum; In Vitro Techniques; Male; Perylene; Phloroglucinol; Phosphodiesterase Inhibitors; Plant Extracts; Quercetin; Rabbits; Terpenes; Verapamil | 2011 |
Antidepressant hyperforin up-regulates VEGF in CNS tumour cells.
Topics: Antidepressive Agents; Apoptosis; Brain Neoplasms; Bridged Bicyclo Compounds; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Precursors; Enzyme-Linked Immunosorbent Assay; Gelatinases; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 9; Medulloblastoma; Neovascularization, Physiologic; Phloroglucinol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; Transcription, Genetic; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A | 2011 |
Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes.
Topics: Bridged Bicyclo Compounds; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hypericum; Microsomes, Liver; Phloroglucinol; Tandem Mass Spectrometry; Terpenes | 2011 |
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemical Fractionation; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flavonols; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2011 |
Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cyclin-Dependent Kinase Inhibitor p27; Cytochromes c; DNA Fragmentation; G1 Phase; Humans; Hypericum; K562 Cells; Mitochondria; Phloroglucinol; Signal Transduction; Terpenes; Tumor Suppressor Protein p53 | 2011 |
Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels.
Topics: Animals; Cells, Cultured; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; I-kappa B Kinase; Models, Neurological; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Neurogenesis; Neurons; NF-kappa B; PC12 Cells; Phloroglucinol; Rats; Receptors, Growth Factor; Receptors, Nerve Growth Factor; RNA, Small Interfering; Signal Transduction; Terpenes; TRPC Cation Channels | 2012 |
Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cell Line; Central Nervous System Agents; Dexamethasone; Estradiol; Humans; Pentylenetetrazole; Phloroglucinol; Rifampin; Staining and Labeling; Terpenes; Up-Regulation; Verapamil | 2011 |
Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cell Line, Tumor; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression; Humans; Pentylenetetrazole; Pharmaceutical Preparations; Phloroglucinol; Rhodamine 123; Rifampin; Stimulation, Chemical; Terpenes; Up-Regulation; Verapamil | 2011 |
The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Caspase 3; DNA Fragmentation; Female; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Mitochondrial Membranes; Myeloid Cell Leukemia Sequence 1 Protein; Phloroglucinol; Phosphatidylserines; Piperidines; Plant Extracts; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Terpenes; Tumor Cells, Cultured | 2011 |
In-vitro antitumor activity evaluation of hyperforin derivatives.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; HeLa Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Phloroglucinol; Terpenes | 2011 |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes | 2011 |
Hyperforin promotes mitochondrial function and development of oligodendrocytes.
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Cells, Cultured; Mitochondria; Oligodendroglia; Phloroglucinol; Rats; Stem Cells; Terpenes | 2011 |
Hyperforin changes the zinc-storage capacities of brain cells.
Topics: 2,2'-Dipyridyl; Animals; Brain; Calcium; Cells, Cultured; Chelating Agents; Disulfides; Dose-Response Relationship, Drug; Ethylenediamines; Gene Expression Regulation; Ionomycin; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Oxidants; Phloroglucinol; Sulfur; Terpenes; Time Factors; Zinc | 2011 |
Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa.
Topics: Aged; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Female; Gene Silencing; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Phloroglucinol; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Terpenes; Transfection; Up-Regulation | 2012 |
Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Female; Humans; Intracellular Space; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitochondrial Membranes; NF-kappa B; Phloroglucinol; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Terpenes; Up-Regulation | 2011 |
The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner.
Topics: Age Factors; Animals; Antidepressive Agents; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neurons; Phloroglucinol; Phosphorylation; Pregnancy; Receptor, trkB; Terpenes; Tissue Distribution; Up-Regulation | 2013 |
Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics.
Topics: Chromatography, High Pressure Liquid; Hypericum; Mass Spectrometry; Metabolome; Molecular Structure; Phloroglucinol; Plant Extracts; Plant Preparations; Principal Component Analysis; Quality Control; Terpenes | 2012 |
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2012 |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Plant Leaves; Plant Stems; Terpenes; Turkey | 2012 |
Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.
Topics: Animals; Calcium; Calcium Channel Blockers; Dendritic Spines; Depression; Gene Expression; Hippocampus; Hypericum; Lanthanum; Organ Culture Techniques; Phloroglucinol; Plant Extracts; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Terpenes; Transfection; TRPC Cation Channels | 2013 |
Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Phloroglucinol; Presenilin-1; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins; Terpenes | 2011 |
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intracellular Space; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Perylene; Phloroglucinol; Photochemotherapy; Reactive Oxygen Species; Terpenes | 2012 |
Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Capillaries; Cells, Cultured; Electric Stimulation; Endothelial Cells; Fluorescent Dyes; Phloroglucinol; Pregnane X Receptor; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Rifampin; RNA; Stimulation, Chemical; Swine; Terpenes; Up-Regulation | 2013 |
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder.
Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Hypericum; Hypoxia; Ischemia; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Perylene; Phloroglucinol; Plant Extracts; Potassium Chloride; Rats; Rats, Sprague-Dawley; Terpenes; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Overactive | 2012 |
Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.
Topics: Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Dizocilpine Maleate; Echocardiography; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; GABAergic Neurons; Heart Failure; Heart Rate; Heart Ventricles; Kidney; Kynurenic Acid; Ligation; Male; Microinjections; Muscimol; Paraventricular Hypothalamic Nucleus; Phloroglucinol; Rats; Rats, Wistar; Splanchnic Nerves; Terpenes; Tritium | 2012 |
Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calpain; Cyclic AMP Response Element-Binding Protein; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Tissue Proteins; Neuroprotective Agents; Phloroglucinol; Phosphorylation; Proteolysis; Rats; Rats, Sprague-Dawley; Terpenes; TRPC Cation Channels | 2013 |
Enantioselective total synthesis of hyperforin.
Topics: Bridged Bicyclo Compounds; Cyclization; Lewis Acids; Molecular Structure; Phloroglucinol; Stereoisomerism; Terpenes | 2013 |
Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antipsychotic Agents; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Exons; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neuropeptides; Phloroglucinol; Presenilin-1; Rats; Rats, Sprague-Dawley; SOXB1 Transcription Factors; Terpenes; Time Factors | 2013 |
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice.
Topics: Aldehydes; Alzheimer Disease; Animals; Brain; Caspase 3; Disease Models, Animal; Enzyme Activation; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Transgenic; Phloroglucinol; Plaque, Amyloid; Receptors, Nicotinic; Terpenes | 2013 |
Downregulation of β1 -adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John's wort.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclic AMP; Down-Regulation; Glioblastoma; Hypericum; Phloroglucinol; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Terpenes | 2013 |
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
Topics: Alzheimer Disease; Amyloid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Hypericum; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phloroglucinol; Plant Extracts; Terpenes | 2014 |
Enhancement of skin radical scavenging activity and stratum corneum lipids after the application of a hyperforin-rich cream.
Topics: Adult; Anti-Inflammatory Agents; Ceramides; Female; Free Radical Scavengers; Humans; Lipids; Male; Phloroglucinol; Skin; Skin Absorption; Skin Cream; Terpenes; Young Adult | 2014 |
Roles of transient receptor potential canonical (TRPC) channels and reverse-mode Na+/Ca2+ exchanger on cell proliferation in human cardiac fibroblasts: effects of transforming growth factor β1.
Topics: Angiotensin II; Calcium; Calcium Signaling; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Diglycerides; Enzyme Inhibitors; Fibroblasts; Humans; Phloroglucinol; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sodium-Calcium Exchanger; Terpenes; Thapsigargin; Thiourea; Transforming Growth Factor beta1; TRPC Cation Channels | 2013 |
TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Hippocampus; MAP Kinase Signaling System; Neurites; Neurons; Oncogene Protein v-akt; PC12 Cells; Phloroglucinol; Phosphatidylinositol 3-Kinases; Phosphorylation; Primary Cell Culture; Rats; Terpenes; TRPC Cation Channels | 2013 |
Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Hippocampus; Mitochondria; Molecular Dynamics Simulation; Neurons; Phloroglucinol; Rats; Terpenes | 2013 |
Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production.
Topics: Biofilms; Enterococcus faecalis; Hypericum; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phloroglucinol; Staphylococcus aureus; Terpenes | 2013 |
Hyperforin inhibits cell proliferation and differentiation in mouse embryonic stem cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Embryonic Stem Cells; Hypericum; Mice; NIH 3T3 Cells; Phloroglucinol; Psychotropic Drugs; Terpenes | 2013 |
In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts.
Topics: Animals; Antineoplastic Agents; Benzophenones; Biological Availability; Biotransformation; Carcinoma; Caspase 3; Cytochrome P-450 CYP3A; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Gene Expression; Half-Life; Hepatocytes; Humans; Injections, Subcutaneous; Ki-67 Antigen; Mice; Mice, Nude; Pancreatic Neoplasms; Phloroglucinol; Primary Cell Culture; Terpenes; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2013 |
St. John's wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity.
Topics: Animals; Cells, Cultured; Cytokines; Cytoprotection; Drug Evaluation, Preclinical; Glucose; Humans; Hypericum; Insulin; Insulin Secretion; Islets of Langerhans; Male; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; Terpenes | 2014 |
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes | 2014 |
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypericum; Maze Learning; Mice; Mice, Transgenic; Microglia; Multidrug Resistance-Associated Proteins; Peptide Fragments; Phagocytes; Phloroglucinol; Phytotherapy; Plant Preparations; Plaque, Amyloid; Terpenes; Time Factors | 2013 |
No activation of human pregnane X receptor by hyperforin-related phloroglucinols.
Topics: Cytochrome P-450 CYP3A; Genes, Reporter; Hep G2 Cells; Hepatocytes; Humans; Luciferases; Molecular Docking Simulation; Phloroglucinol; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Steroid; Terpenes; Transcription, Genetic; Transcriptome | 2014 |
Hyperforin and deoxycohumulone as a larvicidal agent against Culex pipiens (Diptera: Culicidae).
Topics: Animals; Culex; Cyclohexanones; Dose-Response Relationship, Drug; Drug Synergism; Insecticides; Larva; Phloroglucinol; Piperonyl Butoxide; Terpenes | 2014 |
Modulation of oxidative stress and Ca(2+) mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum.
Topics: Animals; Calcium; Cell Survival; Ganglia, Spinal; Hypericum; Male; Neurons; Oxidative Stress; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Terpenes; TRPM Cation Channels | 2014 |
Total syntheses of hyperforin and papuaforins A-C, and formal synthesis of nemorosone through a gold(I)-catalyzed carbocyclization.
Topics: Benzophenones; Biological Products; Catalysis; Cyclization; Gold; Phloroglucinol; Terpenes | 2014 |
Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus.
Topics: Animals; Electroencephalography; Fluorescent Antibody Technique; Male; Microglia; Phloroglucinol; Phosphorylation; Piriform Cortex; Rats; Rats, Sprague-Dawley; Status Epilepticus; Terpenes; Transcription Factor RelA | 2014 |
Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Binding Sites; Diglycerides; Excitatory Postsynaptic Potentials; Hippocampus; Imidazoles; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Phloroglucinol; Protein Structure, Tertiary; Terpenes; TRPC Cation Channels | 2014 |
Characterization of atopic skin and the effect of a hyperforin-rich cream by laser scanning microscopy.
Topics: Administration, Cutaneous; Cosmetics; Dermatitis, Atopic; Humans; Inflammation; Lipids; Microscopy, Confocal; Ointments; Phloroglucinol; Skin; Terpenes | 2015 |
Protonophore properties of hyperforin are essential for its pharmacological activity.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Chromaffin Cells; HEK293 Cells; Humans; Hypericum; Lipid Bilayers; Mice; Mice, Knockout; Microglia; Phloroglucinol; Plant Extracts; Protons; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; TRPC Cation Channels; TRPC6 Cation Channel | 2014 |
DNA-protective activities of hyperforin and aristoforin.
Topics: Antioxidants; DNA; DNA Breaks; Free Radical Scavengers; Hypericum; Iron; Iron Chelating Agents; Phloroglucinol; Terpenes; Topoisomerase I Inhibitors | 2015 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha | 2015 |
The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6.
Topics: Animals; Body Weight; Central Nervous System Agents; Cognition; Cognition Disorders; Dendrites; Depressive Disorder; Dietary Sucrose; Disease Models, Animal; Down-Regulation; Feeding Behavior; Long-Term Potentiation; Male; Maze Learning; Phloroglucinol; Rats, Wistar; Reversal Learning; Social Isolation; Stress, Psychological; Terpenes; TRPC Cation Channels; Uncertainty | 2015 |
Total Synthesis of Hyperforin.
Topics: Chemistry Techniques, Synthetic; Oxidation-Reduction; Phloroglucinol; Terpenes | 2015 |
Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.
Topics: Alzheimer Disease; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Hippocampus; Hypericum; Mice; Microsomes, Liver; Molecular Structure; Phloroglucinol; Terpenes | 2015 |
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy.
Topics: Amyloid beta-Protein Precursor; Animals; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Cells, Cultured; Endoplasmic Reticulum; Fibroblasts; Fluorescent Antibody Technique; Glycosylation; Humans; Immunoenzyme Techniques; Immunoprecipitation; Kidney; Membrane Proteins; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neoplasms; Phloroglucinol; Protein Processing, Post-Translational; Proteolysis; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Terpenes; TOR Serine-Threonine Kinases | 2015 |
Lipid nanocapsules containing the non-ionic surfactant Solutol HS15 inhibit the transport of calcium through hyperforin-activated channels in neuronal cells.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Cetomacrogol; Cholesterol; Culture Media; Dose-Response Relationship, Drug; Mice, Inbred C57BL; Nanocapsules; Neurons; Phloroglucinol; Polyethylene Glycols; Stearic Acids; Surface-Active Agents; Terpenes | 2015 |
The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; HL-60 Cells; Humans; Leukemia; Membrane Potential, Mitochondrial; Mitochondria; Phloroglucinol; Terpenes | 2015 |
Hyperforin alleviates mood deficits of adult rats suffered from early separation.
Topics: Animals; Antidepressive Agents; Exploratory Behavior; Feeding Behavior; Female; Maternal Deprivation; Mood Disorders; Motor Activity; Phloroglucinol; Rats, Wistar; Terpenes | 2015 |
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; RNA, Neoplasm; Terpenes; Tetrazolium Salts; Thiazoles | 2016 |
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.
Topics: Adenoviridae; Biological Products; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Ketoconazole; Microsomes, Liver; Phloroglucinol; Reproducibility of Results; Terpenes; Time Factors | 2015 |
St. John's wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Hypericum; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Phloroglucinol; Phytotherapy; Spleen; T-Lymphocytes, Regulatory; Terpenes | 2016 |
Hyperforin production in Hypericum perforatum root cultures.
Topics: Bioreactors; Hypericum; Phloroglucinol; Plant Extracts; Plant Roots; Terpenes | 2016 |
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.
Topics: Dose-Response Relationship, Drug; Down-Regulation; Hep G2 Cells; Hepatocytes; Humans; Nuclear Receptor Coactivator 1; Octamer Transcription Factor-1; Phloroglucinol; Pregnane X Receptor; Receptors, Steroid; Rifampin; Structure-Activity Relationship; Terpenes; Tumor Cells, Cultured | 2016 |
Tricyclic Acylphloroglucinols from Hypericum lanceolatum and Regioselective Synthesis of Selancins A and B.
Topics: Antineoplastic Agents, Phytogenic; Cameroon; HT29 Cells; Humans; Hypericum; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol; Stereoisomerism; Terpenes | 2016 |
Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Gold; Mice; Mice, Inbred C57BL; Nanoparticles; Phloroglucinol; T-Lymphocytes, Regulatory; Terpenes; Th1 Cells; Th17 Cells | 2016 |
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-450 CYP3A; Firefly Luciferin; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Perylene; Phloroglucinol; Real-Time Polymerase Chain Reaction; Terpenes | 2016 |
Hyperforin promotes post-stroke functional recovery through interleukin (IL)-17A-mediated angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Brain Ischemia; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phloroglucinol; Recovery of Function; Signal Transduction; Stroke; Terpenes; Vascular Endothelial Growth Factor A | 2016 |
TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways.
Topics: Animals; Animals, Newborn; Apoptosis; Calcineurin; Calcium; Calcium Signaling; Caspase 8; Caspase Inhibitors; Cell Division; Cells, Cultured; Egtazic Acid; Fas Ligand Protein; fas Receptor; Ion Transport; Mesangial Cells; NFATC Transcription Factors; Oligopeptides; Oxidative Stress; Phloroglucinol; RNA Interference; RNA, Small Interfering; Signal Transduction; Sus scrofa; Terpenes; TRPC6 Cation Channel | 2016 |
Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor.
Topics: Cell Proliferation; Estrogens; Humans; MCF-7 Cells; Phloroglucinol; Protein Processing, Post-Translational; Proteome; Response Elements; Terpenes; Transfection | 2016 |
St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cytokines; DNA; Enzyme Activation; Hypericum; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Phloroglucinol; Phosphorylation; Plant Extracts; Rats; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Terpenes; Transcriptional Activation | 2016 |
Influence of hyperforin on the morphology of internal organs and biochemical parameters, in experimental model in mice.
Topics: Animals; Biomarkers; Body Weight; Brain; Kidney; Liver; Male; Mice; Models, Animal; Motor Activity; Organ Specificity; Phloroglucinol; Terpenes; Toxicity Tests, Acute | 2016 |
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.
Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes | 2017 |
Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Phloroglucinol; Signal Transduction; Terpenes; Time Factors | 2017 |
Computed Regioselectivity and Conjectured Biological Activity of Ene Reactions of Singlet Oxygen with the Natural Product Hyperforin.
Topics: Biological Products; Hydrogen Peroxide; Phloroglucinol; Photosensitizing Agents; Singlet Oxygen; Terpenes | 2017 |
Hyperforin activates gene transcription involving transient receptor potential C6 channels.
Topics: HEK293 Cells; Humans; Phloroglucinol; Signal Transduction; Terpenes; Transcription, Genetic; TRPC Cation Channels; TRPC6 Cation Channel | 2017 |
Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts - A new option for hypertrophic scar treatment?
Topics: Animals; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cicatrix, Hypertrophic; Dose-Response Relationship, Drug; Fibroblasts; Foreskin; Humans; Infant, Newborn; Male; Phloroglucinol; Rats; Terpenes; Treatment Outcome; Wound Healing | 2018 |
Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach.
Topics: Active Transport, Cell Nucleus; Anticonvulsants; Binding, Competitive; Carbamazepine; Cell Nucleus; Computer Simulation; Hep G2 Cells; Humans; Ketoconazole; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutation; Phloroglucinol; Pregnane X Receptor; Protein Binding; Receptors, Steroid; RNA Interference; Terpenes | 2017 |
Downstream processing of hyperforin from Hypericum perforatum root cultures.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Hypericum; Phloroglucinol; Plant Extracts; Plant Roots; Terpenes | 2018 |
Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation.
Topics: Animals; Brain Infarction; Brain Injuries; Cytokines; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Intercellular Signaling Peptides and Proteins; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neuroprotective Agents; Phloroglucinol; Proprioception; Statistics, Nonparametric; Terpenes | 2018 |
[Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Hippocampus; Maze Learning; Mice; Mice, Transgenic; Peptide Fragments; Phloroglucinol; Terpenes | 2016 |
Hyperforin attenuates aluminum-induced Aβ production and Tau phosphorylation via regulating Akt/GSK-3β signaling pathway in PC12 cells.
Topics: Aluminum; Amyloid beta-Peptides; Animals; Cell Survival; Cytoprotection; Glycogen Synthase Kinase 3 beta; PC12 Cells; Peptide Fragments; Phloroglucinol; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; tau Proteins; Terpenes | 2017 |
Persistence of STAT-1 inhibition and induction of cytokine resistance in pancreatic β cells treated with St John's wort and its component hyperforin.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Hypericum; Insulin-Secreting Cells; Phloroglucinol; Plant Extracts; Rats; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor; Terpenes; Time Factors | 2019 |
Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress.
Topics: Biomarkers; Cell Line; Dexamethasone; Gene Expression Regulation; Glucosides; Humans; Hypericum; Neurons; Phloroglucinol; Quercetin; Stress, Physiological; Terpenes | 2018 |
Hyperforin Suppresses Tumor Growth and NF-κB-mediated Anti-apoptotic and Invasive Potential of Non-small Cell Lung Cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Lung Neoplasms; Neoplasm Invasiveness; NF-kappa B; Phloroglucinol; Signal Transduction; Terpenes; Tumor Burden | 2018 |
Methodological aspects of biologically active compounds quantification in the genus Hypericum.
Topics: Anthracenes; Catechin; Chlorogenic Acid; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Quercetin; Rutin; Terpenes | 2018 |
The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29).
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; HT29 Cells; Humans; Neoplasm Metastasis; Oxaliplatin; Perylene; Phloroglucinol; Terpenes | 2018 |
Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β.
Topics: Animals; Anxiety; Behavior, Animal; Brain Ischemia; Depression; Hippocampus; Male; Mice, Inbred C57BL; Neurogenesis; Phloroglucinol; Recombinant Proteins; Recovery of Function; Social Isolation; Stroke; Terpenes; Transforming Growth Factor beta | 2019 |
Protective Effect of Hyperforin on β Amyloid Protein Induced Apoptosis in PC12 Cells and Colchicine Induced Alzheimer's Disease: An Anti-oxidant and Anti-inflammatory Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Malondialdehyde; Neuroprotective Agents; NF-kappa B; Oxidative Stress; PC12 Cells; Peptide Fragments; Phloroglucinol; Rats; Rats, Wistar; Signal Transduction; Terpenes | 2018 |
Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cytochromes c; Glutathione Peroxidase; Humans; Malondialdehyde; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; PC12 Cells; Phloroglucinol; Proto-Oncogene Proteins c-bcl-2; Pyrones; Rats; Reactive Oxygen Species; Superoxide Dismutase; Terpenes | 2019 |
Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1.
Topics: Biological Transport; Caco-2 Cells; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Interactions; Estrone; HeLa Cells; Hep G2 Cells; Humans; Intestinal Absorption; Organic Anion Transporters; Phloroglucinol; Pregnane X Receptor; Promoter Regions, Genetic; Terpenes | 2019 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Membrane Fluidity; Perylene; Phloroglucinol; Phosphatidylethanolamines; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Signal Transduction; Terpenes | 2019 |
Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort.
Topics: Adult; Alprazolam; Antineoplastic Agents; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hypericum; Imatinib Mesylate; Intestinal Mucosa; Liver; Male; Midazolam; Middle Aged; Models, Biological; Phloroglucinol; Terpenes | 2019 |
Profiling Auspicious Butyrylcholinesterase Inhibitory Activity of Two Herbal Molecules: Hyperforin and Hyuganin C.
Topics: Acetylcholinesterase; Apiaceae; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Coumarins; Molecular Docking Simulation; Phloroglucinol; Plant Extracts; Quantitative Structure-Activity Relationship; Terpenes; Thermodynamics | 2019 |
Antidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Fluoxetine; Frontal Lobe; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phloroglucinol; Stress, Psychological; Terpenes; Zinc | 2019 |
Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.
Topics: Angiogenesis Inducing Agents; Animals; Anthracenes; Biomarkers; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Colorectal Neoplasms; Disease Models, Animal; Gene Expression; Humans; Neovascularization, Pathologic; Perylene; Phloroglucinol; Photochemotherapy; Photosensitizing Agents; Terpenes | 2019 |
Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Sicily; Species Specificity; Terpenes | 2020 |
Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles.
Topics: Adult; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Biological Products; Blood Donors; Capsules; Cells, Cultured; Drug Delivery Systems; Healthy Volunteers; Humans; Hypericum; Lipoxygenase Inhibitors; Nanoparticles; Neutrophils; Phloroglucinol; Plant Extracts; Protein Binding; Serum Albumin, Human; Solubility; Terpenes; Water | 2020 |
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Hypericum; Phloroglucinol; Signal Transduction; Terpenes; Transcription Factor RelA | 2020 |
Pharmacological and genetic inhibition of TRPC6-induced gene transcription.
Topics: Calcium Channel Blockers; HEK293 Cells; Humans; Phloroglucinol; Pregnenolone; RNA, Small Interfering; Signal Transduction; Substrate Specificity; Terpenes; Transcription Factor AP-1; Transcription, Genetic; TRPC6 Cation Channel; TRPM Cation Channels | 2020 |
Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro.
Topics: Animals; Chlorocebus aethiops; Coccidiostats; Cytokines; Hypericum; Inflammation Mediators; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Phloroglucinol; Plant Extracts; RAW 264.7 Cells; Terpenes; Toxoplasma; Toxoplasmosis, Cerebral; Vero Cells | 2021 |
Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model.
Topics: Humans; Insecticides; Liver; Organ Culture Techniques; Permethrin; Phloroglucinol; Skin; Terpenes; Tissue Culture Techniques | 2021 |
Annulative Methods in the Synthesis of Complex Meroterpene Natural Products.
Topics: Biological Products; Bridged Bicyclo Compounds; Cyclization; Cycloaddition Reaction; Molecular Conformation; Oxidation-Reduction; Phloroglucinol; Resorcinols; Stereoisomerism; Terpenes | 2021 |
Hyperforin alleviates the psychiatric disorders of adult rats suffered from early maternal separation via activating autophagy.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Autophagy; Beclin-1; Depression; Disks Large Homolog 4 Protein; Female; Glutamic Acid; Hippocampus; Male; Maternal Deprivation; Phloroglucinol; Rats; Rats, Wistar; Receptor, Notch1; Receptors, N-Methyl-D-Aspartate; Synaptophysin; Terpenes | 2021 |
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Binding Sites; Cold Temperature; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Hypericum; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondrial Proteins; Molecular Docking Simulation; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phloroglucinol; Signal Transduction; Terpenes; Thermogenesis; Uncoupling Protein 1; Up-Regulation | 2021 |
Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species.
Topics: Anthracenes; Chromatography, Thin Layer; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Terpenes | 2022 |
Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin.
Topics: Lithium; Phloroglucinol; Stereoisomerism; Terpenes | 2022 |
Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells.
Topics: beta Catenin; Colonic Neoplasms; HCT116 Cells; Humans; Hypericum; Phloroglucinol; Terpenes; Wnt Signaling Pathway | 2022 |
Convergent gene clusters underpin hyperforin biosynthesis in St John's wort.
Topics: Hypericum; Multigene Family; Phloroglucinol; Phylogeny; Plant Extracts; Plant Oils; Terpenes | 2022 |
Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Hypericum; Mice; Phloroglucinol; Terpenes; TRPC6 Cation Channel | 2022 |
Cytotoxic and Antioxidant Activity of
Topics: Antineoplastic Agents; Antioxidants; Bridged Bicyclo Compounds; Humans; Hypericum; Hypoxia; Melanoma; Neoplastic Processes; Phloroglucinol; Plant Extracts; Terpenes; Tumor Microenvironment | 2023 |