phenytoin and warfarin

phenytoin has been researched along with warfarin in 140 studies

Research

Studies (140)

Timeframe	Studies, this research(%)	All Research%
pre-1990	69 (49.29)	18.7374
1990's	16 (11.43)	18.2507
2000's	31 (22.14)	29.6817
2010's	21 (15.00)	24.3611
2020's	3 (2.14)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Andersson, K; Borg, P; Frostell-Karlsson, A; Hämäläinen, M; Karlsson, R; Remaeus, A; Roos, H	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Afzelius, L; Andersson, TB; Baroni, M; Cruciani, G; Karlén, A; Masimirembwa, CM; Mecucci, S; Zamora, I	1
Caron, G; Ermondi, G	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Birkett, DJ; Graham, GG; Pond, SM; Wade, DN	1
Hansen, M; Kristensen, M; Siersbaek-Nielsen, K; Skovsted, L	1
Richens, A	1
Majewski, F	1
Levy, G; Yacobi, A	1
Nappi, JM	1
Bowmer, CJ; Lindup, WE	1
d'Athis, P; Lecomte, M; Tillement, JP; Zini, R	1
Hintze, KL; Levy, G; Slattery, JT; Wiegand, UW	2
Gallop, PM; Keith, DA	1
Borgå, O; Dahlqvist, R; Juhlin-Dannfeldt, A	1
Lampman, T; Levy, G; Yacobi, A	1
Gibaldi, M; McNamara, PJ	1
Cotham, RH; Shand, DG; Wilkinson, GR	1
De Baere, H	1
Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH	1
Hansen, JM; Kampmann, J; Lumholtz, B; Siersbaek-Nielsen, K; Skovsted, L	1
Cooper, JK; Hubbard, JW; McGilveray, IJ; Midha, KK	1
Davies, RO; Gagnon, MA; McLean, WM; Ruedy, J; Thompson, WG; Vitti, TG; Wilson, TW	1
Halliday, JL; Howe, AM; Lipson, AH; Sheffield, LJ; Webster, WS	1
Carey, D; Lee, HS; Tett, S	1
Humphries, TJ	1
Pannke, TS	1
Panegyres, PK; Rischbieth, RH	1
McNamara, PJ; Stoeckel, K; Trueb, V	1
Branch, RA; Guengerich, FP; Hall, SD; Wilkinson, GR	1
Baciewicz, AM	1
Bachmann, KA; Jahn, D; Schwartz, J; Yang, C	1
Dale, O; Jenssen, U	1
Brouwer, KR; Cook, J; Gwilt, PR; Steinke, M	1
Gugler, R; Jensen, JC	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y	1
Dale, O; Nilsen, OG	1
Dale, O	1
La Du, BN	1
Jatlow, P	1
Vesell, ES	2
McQueen, EG	1
Goedde, HW	1
Granatek, AP; Mihotic, MM; Prasad, VK	1
Hahn, I; Krieglstein, G; Krieglstein, J; Tschentscher, K	1
Azarnoff, DL; Gugler, R; Shoeman, DW	1
Chriske, HW; Hilger, HH; Knabe, M	1
Eipe, J	1
Raisfeld, IH	1
Vorherr, H	1
Hilgartner, MW; Kutt, H; Solomon, GE	1
Du, BN	1
Iber, FL; Kater, RM; Roggin, G; Tobon, F; Zieve, P	1
Altland, K; Goedee, HW	1
Jähnchen, E; Levy, G	1
Koch-Weser, J; Sellers, EM	1
Abrams, WB; Reich, S; Solomon, HM; Spirt, N	1
Black, M	1
Eliot, RS; Ferlic, R; Lillehei, CW; Sellers, RD	1
Hitzenberger, G	1
Stedman, DB; Welsch, F	1
Beckman, DA; Brent, RL	1
Chernoff, GF; Jones, KL	1
Feely, J	1
Dayton, PG; Sanders, JE	1
Furst, DE	1
Ayers, TG; Merryfield, DW; Wilkinson, CA; Williams, RB	1
MacKichan, JJ	1
D'Arcy, PF	1
Papouchado, M; Reed, PI; Thornton, PC	1
Goldberg, DM	1
Bint, AJ; Burtt, I	1
Honda, Y; Katayama, T	1
Babb, RR	1
Lai, CM; Moore, P; Quon, CY	1
Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K	1
Kapetanovic, IM; Kupferberg, HJ; McNeilly, PJ; Strong, JM; Torchin, CD	1
Inoue, K; Mimura, M; Nakamura, S; Oda, H; Ohmori, S; Shimada, T; Yamazaki, H	1
Meisheri, YV	1
Hage, DS; Tweed, SA	1
Birkett, DJ; Miners, JO	1
Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y	1
Adamczyk, M; Fishpaugh, JR; Mattingly, PG	1
Bajpai, M; Haining, RL; Levy, RH; Rettie, AE	1
Feely, J; Kelly, A; Williams, D	1
Abel, R; Alvey, CW; Bron, NJ; Hounslow, NJ; Koup, JR; Randinitis, EJ; Rausch, G; Sedman, AJ; Vassos, AB	1
Asakawa, N; Ishihama, Y; Miwa, T	1
Goldstein, JA; Lee, CR; Pieper, JA	1
Ensom, MH	1
Holmes, LB	1
Bertino, JS; Nafziger, AN; Rogers, JF	1
Haidar, WN; Hoel, RW; Takahashi, PY	1
Awaisu, A; Aziz, NA; Hassan, Y; Ismail, O	1
Cohen, A; Hennessy, S; Kimmel, SE; Koppel, R; Metlay, JP; Polsky, D	1
Counselman, FL; DeLashaw, MR; Vizioli, TL	1
Amistà, P; Briani, C; Munari, M; Pagnan, A; Teresa Sartori, M; Zampieri, P	1
Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ	1
Lee, DY; Shin, WG; Zhu, X	1
Kitano, F; Terasawa, H	1
Cohen, A; Feldman, HI; Haynes, K; Hennessy, S; Kimmel, SE; Leonard, CE; Localio, AR; Metlay, JP; Tjia, J	1
Gunawardhana, L; Lee, RD; Mulford, D; Vakily, M; Wu, J	1
Mosher, CM; Rettie, AE; Tai, G	1
Birnbaum, AK; Catarino, CB; Chaudhry, AS; Goldstein, DB; Kasperaviciute, D; Lamba, JK; Radtke, RA; Remmel, RP; Schuetz, EG; Sisodiya, SM; Strom, S; Subramanian, M; Urban, TJ; You, JH	1
Bergman, U; Bertilsson, L; Engström Hellgren, K; Helldén, A; Masquelier, M; Nilsson Remahl, I; Odar-Cederlöf, I; Ramsjö, M	1
Arakawa, R; Iwaki, Y; Kawasaki, H	1
New, SY; Su, X; Tan, YN; Xie, J; Yu, Y	1
Ferry, J; Gidal, BE; Laurenza, A; Ueno, T	1
Amorosi, CJ; Boyle, G; Chiasson, MA; Dunham, MJ; Fowler, DM; Kowalski, JP; McDonald, MG; Rettie, AE; Sitko, KA; Wong, LH	1
Abu Ghosh, Z; Alamia, S; Caraco, Y; Shaul, C; Wanounou, M	1
Adar, L; Bialer, M; Blotnick, S; Caraco, Y; Muszkat, M; Shaul, C	1

Reviews

26 review(s) available for phenytoin and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[On certain embryopathies induced by teratogenic agents (author's transl]. Monatsschrift fur Kinderheilkunde, 1977, Volume: 125, Issue:6 Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany, West; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Lysergic Acid Diethylamide; Mercaptopurine; Nicotine; Phenytoin; Radiation Injuries; Teratogens; Thalidomide; Trimethadione; Warfarin	1977
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Digestive diseases and sciences, 1991, Volume: 36, Issue:12 Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin	1991
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats. Journal of pharmacokinetics and biopharmaceutics, 1985, Volume: 13, Issue:5 Topics: Animals; Antipyrine; Barbiturates; Biological Availability; Chlorpromazine; Diazepam; Drug Evaluation; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Pentazocine; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Propranolol; Quinidine; Rats; Species Specificity; Tissue Distribution; Tolbutamide; Valproic Acid; Warfarin	1985
Pharmacogenetics: defective enzymes in relation to reactions to drugs. Annual review of medicine, 1972, Volume: 23 Topics: Acetylation; Cholinesterases; Coumarins; Dicumarol; Dose-Response Relationship, Drug; Female; Genetic Code; Genetic Diseases, Inborn; Glucosephosphate Dehydrogenase Deficiency; Humans; Isoniazid; Male; Metabolism, Inborn Errors; Pharmacogenetics; Phenacetin; Phenobarbital; Phenytoin; Succinylcholine	1972
Advances in pharmacogenetics. Progress in medical genetics, 1973, Volume: 9 Topics: Alcohol Oxidoreductases; Catalase; Cholinesterases; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Drug Resistance; Drug-Related Side Effects and Adverse Reactions; Environment; Female; Genetic Diseases, Inborn; Glaucoma; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Infant, Newborn; Intraocular Pressure; Isoniazid; Malignant Hyperthermia; Mutation; Pharmaceutical Preparations; Pharmacogenetics; Phenylthiourea; Phenytoin; Pregnancy; Protein Binding; Racial Groups; Warfarin	1973
Recent progress in pharmacogenetics. Advances in pharmacology, 1969, Volume: 7 Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; Cyanides; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Isoniazid; Liver; Male; Metabolism, Inborn Errors; Middle Aged; Pharmacogenetics; Phenylbutazone; Phenylthiourea; Phenytoin; Pregnancy; Primaquine; Twins; Warfarin	1969
Drugs affecting therapy with anticoagulants. The Medical clinics of North America, 1972, Volume: 56, Issue:1 Topics: Anticoagulants; Chloramphenicol; Clofibrate; Contraceptives, Oral; Coumarins; Diuretics; Drug Interactions; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Estrogens; Ethanol; Heparin; Humans; Hypnotics and Sedatives; Phenylbutazone; Phenytoin; Salicylates; Thyroxine; Tolbutamide; Vitamin K	1972
Clinical pharmacology of drug interactions. Annual review of medicine, 1973, Volume: 24 Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Interactions; Epilepsy; Heparin; Humans; Hypertension; Lidocaine; Mental Disorders; Pharmaceutical Preparations; Phenothiazines; Phenytoin; Procainamide; Salicylates	1973
Drug excretion in breast milk. Postgraduate medicine, 1974, Volume: 56, Issue:4 Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; Chloramphenicol; Contraceptives, Oral; Coumarins; Female; Fluorine; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Lactation; Meprobamate; Milk, Human; Models, Biological; Morphine; Nicotine; Pesticides; Pharmaceutical Preparations; Phenytoin; Potassium Iodide; Pregnancy; Salicylates; Sulfonamides; Time Factors	1974
Pharmacogenetics. The Medical clinics of North America, 1969, Volume: 53, Issue:4 Topics: Biotransformation; Cholinesterases; Coumarins; Genetic Variation; Genetics, Medical; Humans; Isoniazid; Liver; Metabolism, Inborn Errors; Methemoglobinemia; Pharmaceutical Preparations; Pharmacology; Phenacetin; Phenytoin; Succinylcholine	1969
[Genetically dependent variability of drug effects]. Medizinische Klinik, 1970, Aug-28, Volume: 65, Issue:35 Topics: Anemia, Hemolytic; Anesthesia, General; Anesthetics; Animals; Antipyrine; Apnea; Atropine; Body Temperature; Coumarins; Cyanosis; Deficiency Diseases; Dexamethasone; Dogs; Drug Tolerance; Enzymes; Female; Glucosephosphate Dehydrogenase; Humans; Intraocular Pressure; Isonicotinic Acids; Male; Meperidine; Mice; Oxyphenbutazone; Pharmacogenetics; Phenacetin; Phenylbutazone; Phenytoin; Proteins; Rabbits; Rats; Succinylcholine	1970
Mechanisms of teratogenesis. Annual review of pharmacology and toxicology, 1984, Volume: 24 Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilbestrol; Embryo, Mammalian; Ethanol; Female; Fetus; Humans; Methotrexate; Methylmercury Compounds; Mutagens; Nucleic Acids; Oxazoles; Phenytoin; Polychlorinated Biphenyls; Pregnancy; Progestins; Teratogens; Tetracycline; Thalidomide; Thyroid Hormones	1984
Fetal preventive medicine: teratogens and the unborn baby. Pediatric annals, 1981, Volume: 10, Issue:6 Topics: Abnormalities, Drug-Induced; Dronabinol; Drug Evaluation; Ethanol; Female; Heroin; Hormones; Hot Temperature; Humans; Lysergic Acid Diethylamide; Phenytoin; Pregnancy; Registries; Teratogens; Trimethadione; Warfarin; X-Rays	1981
Interaction of cimetidine with other drugs. Southern medical journal, 1983, Volume: 76, Issue:6 Topics: Aged; Chlormethiazole; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Lidocaine; Liver; Liver Circulation; Phenytoin; Propranolol; Tissue Distribution; Warfarin	1983
Dose-dependent pharmacokinetics: emphasis on phase I metabolism. Drug metabolism reviews, 1983, Volume: 14, Issue:3 Topics: 2,4,5-Trichlorophenoxyacetic Acid; Adolescent; Adult; Age Factors; Aged; Animals; Antineoplastic Agents; Child; Child, Preschool; Coumarins; Dioxanes; Dose-Response Relationship, Drug; Humans; Infant; Infant, Newborn; Kinetics; Mathematics; Middle Aged; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Tissue Distribution	1983
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry. Clinical chemistry, 1980, Volume: 26, Issue:6 Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; Energy Intake; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Smoking; Tolbutamide; Warfarin	1980
Adverse antibiotic drug interactions. Drugs, 1980, Volume: 20, Issue:1 Topics: Aminosalicylic Acid; Antacids; Anti-Bacterial Agents; Biological Availability; Contraceptives, Oral; Digitoxin; Drug Interactions; Gastrointestinal Motility; Humans; Hydrogen-Ion Concentration; Kidney; Metals; Phenobarbital; Phenytoin; Rifampin; Sulfonamides; Tetracyclines; Warfarin	1980
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions. Journal of chromatography. B, Biomedical sciences and applications, 1997, Oct-10, Volume: 699, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Pharmaceutical Preparations; Phenytoin; Protein Binding; Proteins; Serum Albumin; Warfarin	1997
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. British journal of clinical pharmacology, 1998, Volume: 45, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Repression; Humans; Pharmaceutical Preparations; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfonamides; Tolbutamide; Torsemide; Warfarin	1998
Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics, 2002, Volume: 12, Issue:3 Topics: Alleles; Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asia; Black People; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Genetics, Population; Genotype; Humans; In Vitro Techniques; Phenytoin; Polymorphism, Genetic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Warfarin; White People	2002
Teratogen-induced limb defects. American journal of medical genetics, 2002, Oct-15, Volume: 112, Issue:3 Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin; Pregnancy; Pregnancy in Diabetics; Substance-Related Disorders; Teratogens; Thalidomide; Valproic Acid; Warfarin	2002
Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs. The American journal of medicine, 2002, Dec-15, Volume: 113, Issue:9 Topics: Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Codeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Diazepam; Genotype; Glipizide; Humans; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics; Phenotype; Phenytoin; Warfarin	2002
[Deadly drug interactions]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Phenytoin; Quinolines; Theophylline; Warfarin	2007

Trials

5 trial(s) available for phenytoin and warfarin

Article	Year
The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta medica Scandinavica, 1976, Volume: 199, Issue:6 Topics: Coumarins; Dicumarol; Half-Life; Humans; Phenindione; Phenprocoumon; Phenytoin; Tolbutamide; Warfarin	1976
Increased rate of clearance of drugs from the circulation of alcoholics. The American journal of the medical sciences, 1969, Volume: 258, Issue:1 Topics: Alcoholism; Clinical Trials as Topic; Ethanol; Humans; Liver; Microsomes; Phenytoin; Tolbutamide; Warfarin	1969
Lack of pantoprazole drug interactions in man. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin	1994
Drug interactions with clinafloxacin. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9 Topics: Adult; Aged; Anti-Infective Agents; Anticonvulsants; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Fluoroquinolones; Humans; Male; Middle Aged; Phenytoin; Theophylline; Warfarin	2001
Drug interaction studies with dexlansoprazole modified release (TAK-390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies. Clinical drug investigation, 2009, Volume: 29, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anticoagulants; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Dexlansoprazole; Diazepam; Double-Blind Method; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Phenytoin; Proton Pump Inhibitors; Theophylline; Warfarin; Young Adult	2009

Other Studies

110 other study(ies) available for phenytoin and warfarin

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels. Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10 Topics: Binding Sites; Biosensing Techniques; Digitoxin; Drug Stability; Humans; Molecular Weight; Naproxen; Orosomucoid; Pharmaceutical Preparations; Protein Binding; Quinine; Rifampin; Ritonavir; Serum Albumin; Solvents; Warfarin	2000
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors. Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4 Topics: Amino Acids; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C9; Enzyme Inhibitors; Models, Molecular; Molecular Conformation; Molecular Structure; Quantitative Structure-Activity Relationship	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Effects of tricyclic antidepressants on drug metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:2 Topics: Adult; Amitriptyline; Dicumarol; Half-Life; Humans; Kinetics; Male; Nortriptyline; Pharmaceutical Preparations; Phenytoin; Time Factors; Tolbutamide; Warfarin	1975
Drug interactions and lethal drug combinations. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Adrenergic Agents; Antidepressive Agents, Tricyclic; Binding, Competitive; Drug Interactions; Enzyme Induction; Humans; Intestinal Absorption; Kidney Tubules; Liver; Monoamine Oxidase Inhibitors; Pharmaceutical Preparations; Phenytoin; Stomach; Sympathomimetics; Warfarin	1975
Intraindividual relationships between serum protein binding of drugs in normal human subjects, patients with impaired renal function, and rats. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:9 Topics: Adolescent; Adult; Animals; Blood Proteins; Female; Humans; Kidney Diseases; Kidney Transplantation; Male; Middle Aged; Pharmaceutical Preparations; Phenytoin; Protein Binding; Rats; Salicylates; Serum Albumin; Sulfisoxazole; Time Factors; Transplantation, Homologous; Warfarin	1977
Warfarin and phenytoin interaction. Annals of internal medicine, 1979, Volume: 90, Issue:5 Topics: Drug Interactions; Humans; Phenytoin; Prothrombin Time; Warfarin	1979
Decreased binding of drugs and dyes to plasma proteins from rats with acute renal failure: effects of ureter ligation and intramuscular injection of glycerol. British journal of pharmacology, 1979, Volume: 66, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Proteins; Coloring Agents; Creatinine; Disease Models, Animal; Female; Glycerol; Male; Phenytoin; Rats; Salicylates; Sex Factors; Urea; Ureter; Warfarin	1979
Phenytoin binding to human albumin. European journal of drug metabolism and pharmacokinetics, 1979, Volume: 4, Issue:1 Topics: Anilino Naphthalenesulfonates; Fatty Acids, Nonesterified; Humans; Imipramine; Palmitic Acids; Phenylbutazone; Phenytoin; Protein Binding; Serum Albumin; Warfarin	1979
Differences in the protein binding of several drugs and bilirubin in serum and heparinized plasma of rats. Life sciences, 1979, Jul-30, Volume: 25, Issue:5 Topics: Animals; Bilirubin; Heparin; Male; Phenytoin; Protein Binding; Rats; Salicylates; Warfarin	1979
Phenytoin, hemorrhage, skeletal defects and vitamin K in the newborn. Medical hypotheses, 1979, Volume: 5, Issue:12 Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Factors; Bone and Bones; Chick Embryo; Female; Hemostasis; Humans; Maternal-Fetal Exchange; Microsomes, Liver; Oxidation-Reduction; Phenytoin; Pregnancy; Vitamin K 1; Vitamin K Deficiency; Vitamin K Deficiency Bleeding; Warfarin	1979
Plasma levels and protein binding of phenytoin during exercise in man: the effect of elevated free fatty acids. Pharmacology, 1978, Volume: 16, Issue:1 Topics: Adult; Fatty Acids, Nonesterified; Female; Humans; Male; Phenytoin; Physical Exertion; Protein Binding; Warfarin	1978
Frequency distribution of free warfarin and free phenytoin fraction values in serum of healthy human adults. Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:3 Topics: Adolescent; Adult; Blood Proteins; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding; Serum Albumin; Warfarin	1977
Tissue binding of drugs. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:8 Topics: Animals; Blood Proteins; Humans; Kidney Diseases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Protein Binding; Rats; Warfarin	1977
Perfusion-limited of plasma drug binding on hepatic drug extraction. Life sciences, 1976, Jul-01, Volume: 19, Issue:1 Topics: Animals; Carrier Proteins; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Models, Biological; Phenytoin; Propranolol; Rats; Warfarin	1976
[Alcohol and drugs]. Tijdschrift voor gastro-enterologie, 1976, Volume: 19, Issue:2 Topics: Acetaldehyde; Acetyl Coenzyme A; Anesthetics; Barbiturates; Drug Interactions; Ethanol; Humans; Hypnotics and Sedatives; Intestinal Absorption; Isoniazid; Pharmaceutical Preparations; Phenytoin; Tolbutamide; Warfarin	1976
Decreased capacity to metabolize diphenylhydantoin in a patient with hypersensitivity to warfarin. Australian and New Zealand journal of medicine, 1975, Volume: 5, Issue:5 Topics: Half-Life; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Phenobarbital; Phenytoin; Warfarin	1975
Letter: Potentiations of warfarin by co-trimoxazole. British medical journal, 1975, Jun-21, Volume: 2, Issue:5972 Topics: Drug Synergism; Humans; Phenytoin; Prothrombin Time; Sulfamethoxazole; Trimethoprim; Warfarin	1975
Sulfamethizole-induced inhibition of diphenlhydantoin, tolbutamide, and warfarin metabolism. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Depression, Chemical; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Phenytoin; Sulfamethizole; Sulfathiazoles; Tolbutamide; Ultrafiltration; Warfarin	1975
GLC determination of plasma concentrations of phenprocoumon. Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:3 Topics: Alkylating Agents; Aniline Compounds; Animals; Chromatography, Gas; Coumarins; Dogs; Drug Stability; Humans; In Vitro Techniques; Methods; Methylation; Phenprocoumon; Phenytoin; Time Factors	1976
Letter: Drug bioavailability. Canadian Medical Association journal, 1976, Jul-17, Volume: 115, Issue:2 Topics: Biological Availability; Biopharmaceutics; Digoxin; Phenylbutazone; Phenytoin; Warfarin	1976
Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis. Australian dental journal, 1992, Volume: 37, Issue:6 Topics: Adolescent; Alcoholism; Aneurysm, Ruptured; Animals; Cartilage; Child, Preschool; Female; Humans; Infant; Intracranial Aneurysm; Male; Maxilla; Nasal Bone; Nasal Septum; Phenytoin; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Thrombophlebitis; Vitamin K; Vitamin K Deficiency; Warfarin	1992
Drug interactions with fluconazole. The Medical journal of Australia, 1992, Mar-02, Volume: 156, Issue:5 Topics: Cross-Sectional Studies; Cyclosporine; Drug Interactions; Fluconazole; Humans; Phenytoin; Theophylline; Warfarin	1992
Cerebral dural sinus thrombosis. Annals of emergency medicine, 1991, Volume: 20, Issue:7 Topics: Adult; Cerebral Hemorrhage; Contraceptives, Oral; Diagnosis, Differential; Female; Headache; Hemiplegia; Heparin; Humans; Magnetic Resonance Imaging; Mannitol; Phenytoin; Seizures; Sinus Thrombosis, Intracranial; Tomography, X-Ray Computed; Warfarin	1991
Fatal phenytoin warfarin interaction. Postgraduate medical journal, 1991, Volume: 67, Issue:783 Topics: Aged; Drug Synergism; Drug Therapy, Combination; Heart Arrest; Humans; Male; Myocardial Infarction; Phenytoin; Warfarin	1991
Ceftriaxone binding to human serum albumin. Indirect displacement by probenecid and diazepam. Biochemical pharmacology, 1990, Sep-15, Volume: 40, Issue:6 Topics: Binding Sites; Blood Proteins; Ceftriaxone; Chromatography, High Pressure Liquid; Diazepam; Drug Interactions; Fatty Acids, Nonesterified; Humans; Phenytoin; Probenecid; Serum Albumin; Warfarin	1990
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenytoin; Polymorphism, Genetic; Stereoisomerism; Warfarin	1987
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. I. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Liver; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Rats; Rats, Inbred Strains; Theophylline; Valproic Acid; Warfarin	1988
Interaction of isoflurane with the binding of drugs to proteins in serum and liver cell cytosol. An in vitro study. British journal of anaesthesia, 1986, Volume: 58, Issue:9 Topics: Animals; Blood Proteins; Cytosol; Diazepam; Drug Interactions; Humans; In Vitro Techniques; Isoflurane; Liver; Phenytoin; Rats; Warfarin	1986
Computerized drug therapy: application of the hand-held microcomputer to dosage regimen design. International journal of bio-medical computing, 1985, Volume: 17, Issue:1 Topics: Computers; Digoxin; Female; Gentamicins; Humans; Male; Microcomputers; Middle Aged; Pharmaceutical Preparations; Phenytoin; Software; Theophylline; Warfarin	1985
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gastroenterology, 1985, Volume: 89, Issue:6 Topics: Adult; Benzimidazoles; Coumarins; Diazepam; Drug Interactions; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nordazepam; Omeprazole; Oxidation-Reduction; Phenytoin	1985
Binding and distribution of restrictively and non-restrictively eliminated drugs to serum and liver cell cytosol: effects of volatile anaesthetics. British journal of anaesthesia, 1986, Volume: 58, Issue:1 Topics: Adult; Animals; Binding Sites; Cytosol; Diazepam; Enflurane; Halothane; Humans; Kinetics; Liver; Male; Phenytoin; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Trifluoroacetic Acid; Warfarin	1986
The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin. An in vitro study. Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4 Topics: Binding Sites; Binding, Competitive; Enflurane; Fluoroacetates; Halothane; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Models, Chemical; Phenytoin; Protein Binding; Serum Albumin; Trifluoroacetic Acid; Warfarin	1986
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences. American journal of clinical pathology, 1973, Volume: 59, Issue:2 Topics: Acetaminophen; Barbiturates; Chlorothiazide; Chlorpropamide; Dicumarol; Humans; Methods; Nicotinic Acids; Oxyphenbutazone; Phenacetin; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Salicylates; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Sulfinpyrazone; Sulfisoxazole; Theobromine; Theophylline; Warfarin	1973
Drug displacement from protein-binding and redistributional interactions. Progress in biochemical pharmacology, 1974, Volume: 9 Topics: Animals; Blood Proteins; Carboxylic Acids; Clofibrate; DDT; Dieldrin; Guanidines; Hexachlorocyclohexane; Humans; Kinetics; Oxyphenbutazone; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Protein Binding; Rats; Sheep; Ultrafiltration; Warfarin	1974
[Pharmacogenetics: variability of drug effects and metabolic reactions]. Der Internist, 1974, Volume: 15, Issue:1 Topics: Acetyltransferases; Anemia, Hemolytic, Congenital; Anesthesia; Animals; Biopharmaceutics; Cholinesterases; Coumarins; Dexamethasone; Dextrans; Drug Hypersensitivity; Drug Resistance; Drug Tolerance; Gene Frequency; Genetics, Population; Glucosephosphate Dehydrogenase Deficiency; Haplorhini; Hemoglobins, Abnormal; Humans; Intraocular Pressure; Isoniazid; Metabolism; Pharmacogenetics; Phenacetin; Phenytoin; Species Specificity; Succinylcholine	1974
Physical compatibility and chemical stability of cephapirin sodium in combination with non-antibiotic drugs in large-volume parenteral solutions. II. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:0 Topics: Acetamides; Aminophylline; Ascorbic Acid; Barbiturates; Bicarbonates; Calcium Chloride; Cephalosporins; Chemical Phenomena; Chemistry; Diphenhydramine; Drug Combinations; Drug Incompatibility; Drug Stability; Epinephrine; Ergonovine; Heparin; Hydrocortisone; Hydrogen-Ion Concentration; Metaraminol; Nitrofurantoin; Norepinephrine; Phenytoin; Pyridines; Solutions; Succinylcholine; Sulfadiazine; Sulfides; Sulfisoxazole; Thiopental; Vitamins; Warfarin	1974
Distribution of chlorpromazine in a simplified blood influenced by various drugs. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 278, Issue:1 Topics: Acetazolamide; Animals; Antidepressive Agents; Benzoates; Binding Sites; Binding, Competitive; Cattle; Chlorothiazide; Chlorpromazine; Coumarins; Deoxycholic Acid; Erythrocytes; Fatty Acids; Indomethacin; Phenylbutazone; Phenytoin; Probenecid; Protein Binding; Quinine; Salicylates; Serum Albumin, Bovine; Solubility; Sulfonamides; Suramin; Tetracycline; Thiopental	1973
Effect of in vivo elevation of free fatty acids on protein binding of drugs. Pharmacology, 1974, Volume: 12, Issue:3 Topics: Animals; Binding, Competitive; Epinephrine; Fatty Acids, Nonesterified; Male; Osmolar Concentration; Phenytoin; Physical Exertion; Protein Binding; Rats; Stimulation, Chemical; Warfarin	1974
[Effect of phenytoin containing anti-arrhythmia agents on kinetics and dynamics of coumarine-type anticoagulants]. Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1974, Volume: 40 Topics: Coumarins; Drug Interactions; Humans; Kinetics; Phenytoin	1974
Coagulation defects caused by diphenylhydantoin. Neurology, 1972, Volume: 22, Issue:11 Topics: Animals; Blood Coagulation Disorders; Blood Coagulation Factors; Cats; Factor IX; Factor V; Factor VII; Factor VIII; Factor X; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver; Liver Function Tests; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Prothrombin Time; Thromboplastin; Vitamin K; Warfarin	1972
Determination of phenylbutazone in plasma. Clinical chemistry, 1972, Volume: 18, Issue:9 Topics: Animals; Injections, Intravenous; Male; Methods; Oxidation-Reduction; Phenobarbital; Phenylbutazone; Phenytoin; Potassium Permanganate; Rats; Salicylates; Spectrophotometry; Spectrum Analysis; Sulfadiazine; Time Factors; Ultraviolet Rays; Warfarin	1972
Oral anticoagulant therapy. Canadian Medical Association journal, 1972, Feb-19, Volume: 106, Issue:4 Topics: Administration, Oral; Anti-Bacterial Agents; Anticoagulants; Chloral Hydrate; Drug Synergism; Humans; Phenytoin; Vitamin K; Warfarin	1972
Non-equivalent preparations of the same drug. Drug and therapeutics bulletin, 1971, Aug-13, Volume: 9, Issue:17 Topics: Chloramphenicol; Dosage Forms; Humans; Nitrofurantoin; Oxytetracycline; Pharmaceutical Preparations; Phenindione; Phenobarbital; Phenylbutazone; Phenytoin; Tetracycline; Therapeutic Equivalency; Tolbutamide; Warfarin	1971
Interactions between digitoxin and other drugs in vitro and in vivo. Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179 Topics: Binding Sites; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Clofibrate; Digitoxin; Digoxin; Drug Antagonism; Enzyme Induction; Erythrocytes; Humans; Microsomes, Liver; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Radioisotopes; Rubidium; Serum Albumin; Sulfadimethoxine; Tolbutamide; Tritium; Warfarin	1971
Drugs and the liver. Transactions of the Medical Society of London, 1970, Volume: 86 Topics: Bilirubin; Cushing Syndrome; DDT; Enzyme Induction; Ethanol; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Liver; Male; Phenobarbital; Phenytoin; Porphyrins; Pregnancy; Transferases; Warfarin	1970
Unexpected events attending elective D.C. cardioversion for atrial fibrillation. Geriatrics, 1966, Volume: 21, Issue:11 Topics: Adult; Anesthesia, General; Atrial Fibrillation; Digitalis Glycosides; Electric Countershock; Female; Heparin; Humans; Male; Middle Aged; Phenytoin; Procainamide; Quinidine; Warfarin	1966
[Drug interactions as a cause for iatrogenic diseases in the aged. A tabulated presentation]. Aktuelle Gerontologie, 1983, Volume: 13, Issue:5 Topics: Aged; Alcohol Drinking; Binding, Competitive; Blood Proteins; Drug Interactions; Enzyme Induction; Ethanol; Humans; Iatrogenic Disease; Phenytoin; Protein Binding; Receptors, Drug; Tissue Distribution; Tolbutamide; Warfarin	1983
Inhibition of metabolic cooperation between Chinese hamster V79 cells by structurally diverse teratogens. Teratogenesis, carcinogenesis, and mutagenesis, 1984, Volume: 4, Issue:3 Topics: Animals; Ascorbic Acid; Cell Communication; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; Ethylene Glycols; Lung; Mutation; Phenytoin; Saccharin; Teratogens; Tetradecanoylphorbol Acetate; Warfarin	1984
Use of ibuprofen in unusual circumstances. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersensitivity; Drug Interactions; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Kidney; Kinetics; Lithium; Liver; Lupus Erythematosus, Systemic; Mixed Connective Tissue Disease; Phenytoin; Platelet Aggregation; Prostaglandins E; Warfarin	1984
Clinical pharmacy services in a rehabilitation facility. American journal of hospital pharmacy, 1983, Volume: 40, Issue:9 Topics: Contract Services; Drug Information Services; Financial Management; Hospital Bed Capacity, 300 to 499; Humans; Hypertension; Missouri; Patient Education as Topic; Pharmacy Service, Hospital; Phenytoin; Referral and Consultation; Rehabilitation Centers; Warfarin; Water-Electrolyte Imbalance	1983
Pharmacokinetic consequences of drug displacement from blood and tissue proteins. Clinical pharmacokinetics, 1984, Volume: 9 Suppl 1 Topics: Binding, Competitive; Blood Proteins; Half-Life; Humans; Kinetics; Pharmaceutical Preparations; Phenytoin; Protein Binding; Warfarin	1984
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
Carbenoxolone interactions in man--preliminary report. Scandinavian journal of gastroenterology. Supplement, 1980, Volume: 65 Topics: Carbenoxolone; Chlorpropamide; Drug Interactions; Glycyrrhetinic Acid; Half-Life; Humans; Phenytoin; Protein Binding; Stomach Ulcer; Tolbutamide; Warfarin	1980
[Diphenylhydantoin interaction with warfarin]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1982, Aug-10, Volume: 71, Issue:8 Topics: Adult; Aged; Drug Synergism; Female; Humans; Male; Middle Aged; Phenytoin; Prothrombin Time; Warfarin	1982
Drug interactions with cimetidine. Postgraduate medicine, 1981, Volume: 70, Issue:5 Topics: Chlordiazepoxide; Cimetidine; Diazepam; Drug Interactions; Guanidines; Humans; Phenytoin; Propranolol; Theophylline; Warfarin	1981
Protein binding of several drugs in serum and plasma of healthy subjects. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:3 Topics: Adult; Bilirubin; Female; Heparin; Humans; Isoelectric Point; Male; Phenytoin; Plasticizers; Propranolol; Protein Binding; Salicylates; Warfarin	1980
Binding of fosphenytoin, phosphate ester pro drug of phenytoin, to human serum proteins and competitive binding with carbamazepine, diazepam, phenobarbital, phenylbutazone, phenytoin, valproic acid or warfarin. Research communications in molecular pathology and pharmacology, 1995, Volume: 88, Issue:1 Topics: Adult; Anticonvulsants; Binding Sites; Binding, Competitive; Blood Proteins; Humans; In Vitro Techniques; Kinetics; Male; Orosomucoid; Phenytoin; Protein Binding; Serum Albumin; Warfarin	1995
Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Furans; Gas Chromatography-Mass Spectrometry; Humans; Isoenzymes; Lamotrigine; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Recombinant Proteins; Stereoisomerism; Triazines	1996
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Archives of toxicology, 1997, Volume: 71, Issue:6 Topics: Adrenergic beta-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Benzphetamine; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Dogs; Erythromycin; Ethanolamines; Ethylmorphine; Guinea Pigs; Humans; Macaca fascicularis; Mephenytoin; Microsomes, Liver; Nifedipine; Oxazines; Oxidation-Reduction; Phenacetin; Phenytoin; Rats; Species Specificity	1997
Simultaneous phenytoin and warfarin toxicity on chronic concomitant therapy. The Journal of the Association of Physicians of India, 1996, Volume: 44, Issue:9 Topics: Adult; Anticoagulants; Anticonvulsants; Diplopia; Drug Therapy, Combination; Dysarthria; Dyskinesia, Drug-Induced; Humans; Male; Phenytoin; Warfarin	1996
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:2 Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifibrinolytic Agents; Blood Coagulation; Carbamazepine; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Phenytoin; Piperidines; Prothrombin Time; Rifampin; Sulfonamides; Thromboembolism; Thromboplastin; Vitamin K 1; Warfarin	1998
Resin-supported labeling reagents. Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2 Topics: Acridines; Biotin; Chromatography, High Pressure Liquid; Coumarins; Esters; Estriol; Fluorescein; Haptens; Phenytoin; Resins, Plant; Thyroxine	1999
A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin. Epilepsy research, 1999, Volume: 35, Issue:3 Topics: Animals; Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Genotype; Insecta; Kinetics; Phenotype; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Warfarin	1999
Drug interactions avoided-a useful indicator of good prescribing practice. British journal of clinical pharmacology, 2000, Volume: 49, Issue:4 Topics: Anticoagulants; Anticonvulsants; Cimetidine; Drug Interactions; Drug Prescriptions; Histamine H2 Antagonists; Humans; Ireland; Odds Ratio; Phenytoin; Theophylline; Vasodilator Agents; Warfarin	2000
Drug-plasma protein binding assay by electrokinetic chromatography-frontal analysis. Electrophoresis, 2002, Volume: 23, Issue:6 Topics: beta-Cyclodextrins; Blood Proteins; Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Diclofenac; Electrophoresis, Capillary; Humans; Ketoprofen; Pharmaceutical Preparations; Phenylbutazone; Phenytoin; Serum Albumin; Sulfathiazole; Sulfathiazoles; Warfarin	2002
Comment: unbound drug concentration versus unbound drug fraction. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:4 Topics: Phenytoin; Protein Binding; Warfarin	2002
Intracerebral hemorrhage associated with use of an imported medication. The American journal of geriatric pharmacotherapy, 2004, Volume: 2, Issue:3 Topics: Aged; Anticoagulants; Anticonvulsants; Cerebral Hemorrhage; Drug Contamination; Drug Labeling; Female; Humans; International Normalized Ratio; Medication Errors; Phenytoin; Tablets; Warfarin	2004
The complexity of achieving anticoagulation control in the face of warfarin-phenytoin interaction: an Asian case report. Pharmacy world & science : PWS, 2005, Volume: 27, Issue:1 Topics: Aged; Anticoagulants; Anticonvulsants; Drug Synergism; Heart Valve Prosthesis; Humans; International Normalized Ratio; Male; Phenytoin; Seizures; Warfarin	2005
Medication safety in older adults: home-based practice patterns. Journal of the American Geriatrics Society, 2005, Volume: 53, Issue:6 Topics: Aged; Aged, 80 and over; Cognition Disorders; Cohort Studies; Digoxin; Female; Health Behavior; Health Services Accessibility; Health Status; Home Nursing; Humans; Male; Medication Errors; Patient Education as Topic; Pennsylvania; Phenytoin; Population Surveillance; Prospective Studies; Self Administration; Warfarin	2005
Headache and seizure in a young woman postpartum. The Journal of emergency medicine, 2005, Volume: 29, Issue:3 Topics: Adult; Anticoagulants; Cerebral Angiography; Female; Headache; Humans; Hypertension; Phenytoin; Puerperal Disorders; Risk Factors; Seizures; Sinus Thrombosis, Intracranial; Tomography, X-Ray Computed; Warfarin	2005
Cerebral venous thrombosis as a rare onset of Churg-Strauss syndrome. Thrombosis and haemostasis, 2006, Volume: 96, Issue:1 Topics: Adult; Churg-Strauss Syndrome; Female; Humans; Intracranial Thrombosis; Magnetic Resonance Imaging; Mononeuropathies; Phenytoin; Seizures; Steroids; Treatment Outcome; Warfarin	2006
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin	2006
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:3 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Area Under Curve; Clarithromycin; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Oxadiazoles; Phenytoin; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Factors; Sulfonamides; Torsemide; Warfarin	2007
Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events. Journal of clinical epidemiology, 2008, Volume: 61, Issue:6 Topics: Adverse Drug Reaction Reporting Systems; Aged; Anti-Arrhythmia Agents; Anticoagulants; Anticonvulsants; Cross-Sectional Studies; Digoxin; Drug-Related Side Effects and Adverse Reactions; Forms and Records Control; Hospitalization; Humans; International Classification of Diseases; Medical Records; Patient Discharge; Pennsylvania; Phenytoin; Warfarin	2008
CYP2C9 amino acid residues influencing phenytoin turnover and metabolite regio- and stereochemistry. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3 Topics: Amino Acid Substitution; Amino Acids; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Catalytic Domain; Cytochrome P-450 CYP2C9; Humans; Kinetics; Models, Molecular; Phenytoin; Recombinant Fusion Proteins; Stereoisomerism; Tandem Mass Spectrometry; Warfarin	2009
CYP2C91B promoter polymorphisms, in linkage with CYP2C192, affect phenytoin autoinduction of clearance and maintenance dose. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Enzyme Induction; Epilepsy; Genotype; Hep G2 Cells; Humans; Linkage Disequilibrium; Liver; Microsomes, Liver; Molecular Sequence Data; Phenytoin; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Warfarin	2010
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. European journal of clinical pharmacology, 2010, Volume: 66, Issue:8 Topics: Alleles; Angiotensin II Type 1 Receptor Blockers; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Ataxia; Behcet Syndrome; Case-Control Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Fluconazole; Humans; Losartan; Middle Aged; Pharmaceutical Preparations; Phenotype; Phenytoin; Polymorphism, Genetic; Speech Intelligibility; Warfarin	2010
Human serum albumin-modified Fe3O4 magnetic nanoparticles for affinity-SALDI-MS of small-molecule drugs in biological liquids. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2012, Volume: 28, Issue:9 Topics: Camptothecin; Ferrosoferric Oxide; Humans; Ibuprofen; Magnetite Nanoparticles; Molecular Weight; Phenytoin; Sensitivity and Specificity; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Warfarin	2012
Protein-based fluorescent metal nanoclusters for small molecular drug screening. Chemical communications (Cambridge, England), 2014, Nov-18, Volume: 50, Issue:89 Topics: Drug Evaluation, Preclinical; Fluorescent Dyes; Gold; Ibuprofen; Nanostructures; Phenytoin; Serum Albumin; Sulfanilamide; Sulfanilamides; Warfarin	2014
Potential protein-binding displacement interactions with perampanel: An in vitro analysis. Epilepsy research, 2019, Volume: 149 Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Humans; In Vitro Techniques; Nitriles; Phenytoin; Plasma; Protein Binding; Pyridones; Warfarin	2019
Massively parallel characterization of CYP2C9 variant enzyme activity and abundance. American journal of human genetics, 2021, 09-02, Volume: 108, Issue:9 Topics: Binding Sites; Cytochrome P-450 CYP2C9; Enzyme Assays; Gene Library; High-Throughput Screening Assays; Humans; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Phenytoin; Polymorphism, Genetic; Prescription Drugs; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Saccharomyces cerevisiae; Transgenes; Warfarin; Xenobiotics	2021
The Impact of CYP2C911 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin. Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:1* Topics: Alleles; Anticoagulants; Cytochrome P-450 CYP2C9; Genotype; Humans; Phenytoin; Warfarin	2022
Phenytoin Metabolic Ratio, a Marker of CYP2C9 Activity, is Superior to the CYP2C9 Genotype as a Predictor of (S)-Warfarin Clearance. Clinical pharmacokinetics, 2022, Volume: 61, Issue:8 Topics: Anticoagulants; Biomarkers; Cytochrome P-450 CYP2C9; Genotype; Humans; Phenytoin; Warfarin	2022