phenytoin and vitamin b 12

phenytoin has been researched along with vitamin b 12 in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (78.72)	18.7374
1990's	3 (6.38)	18.2507
2000's	2 (4.26)	29.6817
2010's	4 (8.51)	24.3611
2020's	1 (2.13)	2.80

Authors

Authors	Studies
Chokroverty, S; Sayeed, ZA	1
Adaros, HL; Barboza, JJ; Fuenzalida, E; Furst, J; Oviedo, AM; Porras, C	1
Gautieri, RF; Mann, DE; Mitala, JJ	1
Chanarin, I; Laundy, M; Reid, C; Reynolds, EH; Taguchi, H	1
Aarli, JA	1
Chadwick, D; Chanarin, I; Jenner, P; Reynolds, EH	1
Gill, DS; Latham, J; Wickramasinghe, SN	1
Cowie, VA; Deb, S; Richens, A	1
Gautieri, RF; Mann, DE	1
Fraser, FC; Marsh, L	1
Arakawa, T	1
Matthews, DM; Reynolds, EH	1
Chanarin, I; Matthews, DM; Reynolds, EH	1
Leary, PM	1
Taguchi, H	1
Gardner, AJ	1
Eisen, AA; Sherwin, AL; Woods, JF	1
Herbert, V	1
Elveback, LR; Kurland, LT; Yoshimasu, F	1
Frenkel, EP; McCall, MS; Sheehan, RG	1
Himanen, P; Markkanen, T; Pajula, RL; Virtanen, S	1
Arakawa, T; Hirono, H; Honda, Y; Narisawa, K; Yoshida, T	1
Henriksen, O; Loyning, Y	1
Arakawa, T; Honda, Y; Narisawa, K	1
Reynolds, EH	2
Arimura, GK; Blasquez, J; Halloran, M; Lutcher, CL; Yunis, AA	1
Moe, PJ; Wefring, KW	1
Johnson, AL; Preece, J; Reynolds, EH	1
Boykin, ME; Hooshmand, H	1
Jensen, ON; Olesen, OV	1
Hosokawa, K; Kugoh, T	1
Greene, W	1
Botez, MI; Botez, T; Lalonde, R; Ross-Chouinard, A	1
Fiehn, W; Kohl, B; Rieser, PA; Ringleb, P; Schwaninger, M; Walter-Sack, I; Winter, R	1
Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE	1
CHALMERS, JN; HORSFIELD, GI	1
SPARBERG, M	1
KLIPSTEIN, FA	1
ANAND, MP	1
Coker, I; Karaguzel, O; Ozdamar, O; Sener, U; Topbas, M; Zorlu, Y	1
Dasari, S; Naha, K; Prabhu, M; Vivek, G	1
Huang, H; Wang, N; Yu, C; Zhou, H	1
Sharma, TK; Sitaraman, S; Vardey, SK	1
Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N	1
Kathiravan, M; Kavitha, S; Shanthi, R	1

Reviews

6 review(s) available for phenytoin and vitamin b 12

Article	Year
Congenital and acquired disturbances of histidine metabolism. Clinics in endocrinology and metabolism, 1974, Volume: 3, Issue:1 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Animals; Biopsy; Carbon Radioisotopes; Child; Child, Preschool; Diet Therapy; Female; FIGLU Test; Histidine; Histidine Ammonia-Lyase; Humans; Infant, Newborn; Intellectual Disability; Liver; Male; Phenytoin; Rats; Seizures; Skin; Speech Disorders; Transferases; Urocanate Hydratase; Vitamin B 12	1974
The five possible causes of all nutrient deficiency: illustrated by deficiencies of vitamin B 12 and folic acid. Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:1 Topics: Bile; Biological Transport, Active; Enzymes; Folic Acid; Folic Acid Deficiency; Food Deprivation; Gastric Juice; Humans; Intestinal Absorption; Intestinal Diseases, Parasitic; Nutrition Disorders; Nutritional Requirements; Phenytoin; Polycythemia; Vitamin B 12; Vitamin B 12 Deficiency	1972
Cerebrospinal folate levels in epileptics and their response to folate therapy. Nutrition reviews, 1974, Volume: 32, Issue:3 Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Tetrahydrofolates; Vitamin B 12	1974
Drug interactions involving cimetidine--mechanisms, documentation, implications. Quarterly reviews on drug metabolism and drug interactions, 1984, Volume: 5, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antacids; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Antifungal Agents; Aspirin; Benzodiazepines; Cimetidine; Digoxin; Drug Interactions; Humans; Intestinal Absorption; Iron; Lidocaine; Pancreas; Phenytoin; Prednisolone; Theophylline; Vitamin B 12	1984
DIAGNOSTICALLY CONFUSING COMPLICATIONS OF DIPHENYLHYDANTOIN THERAPY. A REVIEW. Annals of internal medicine, 1963, Volume: 59 Topics: Adrenal Insufficiency; Anemia; Anemia, Aplastic; Anemia, Macrocytic; Conjunctivitis; Electrocardiography; Folic Acid; Heart Failure; Hepatitis; Hypertrichosis; Hypopituitarism; Hypothalamus; Leukopenia; Lymph Nodes; Metabolism; Methemoglobinemia; Pharmacology; Phenytoin; Pulmonary Fibrosis; Thrombocytopenia; Thyroid Function Tests; Toxicology; Vitamin B 12	1963
Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). Medicine, 2019, Volume: 98, Issue:12 Topics: Anticonvulsants; Epilepsy; Folic Acid; Homocysteine; Humans; Phenytoin; Research Design; Vitamin B 12	2019

Trials

2 trial(s) available for phenytoin and vitamin b 12

Article	Year
Cerebrospinal folate levels in epileptics and their response to folate therapy. Nutrition reviews, 1974, Volume: 32, Issue:3 Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Tetrahydrofolates; Vitamin B 12	1974
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale. Epilepsy research, 1993, Volume: 16, Issue:2 Topics: Adult; Brain; Double-Blind Method; Drug Therapy, Combination; Education; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Thiamine; Vitamin B 12; Wechsler Scales	1993

Other Studies

40 other study(ies) available for phenytoin and vitamin b 12

Article	Year
Motor nerve conduction study in patients on diphenylhydantoin therapy. Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:12 Topics: Adolescent; Adult; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Motor Neurons; Neural Conduction; Peripheral Nervous System Diseases; Phenytoin; Time Factors; Vitamin B 12	1975
Recovery from rabies in man. Annals of internal medicine, 1976, Volume: 85, Issue:1 Topics: Adrenocorticotropic Hormone; Antibodies, Viral; Betamethasone; Biperiden; Diazepam; Diphenhydramine; Female; Follow-Up Studies; Humans; Immunization, Secondary; Infusions, Parenteral; Middle Aged; Phenytoin; Rabies; Rabies Vaccines; Remission, Spontaneous; Thiamine; Vitamin B 12	1976
Influence of cobalt (dietary), cobalamins, and inorganic cobalt salts on phenytoin- and cortisone-induced teratogenesis in mice. Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:3 Topics: Animals; Body Weight; Cobalt; Cortisone; Female; Fetus; Male; Maternal-Fetal Exchange; Mice; Organ Size; Phenytoin; Pregnancy; Sex Ratio; Teratogens; Vitamin B 12	1978
The effect of anticonvulsant drugs on thymidine and deoxyribosenucleic acid synthesis by human marrow cells. British journal of haematology, 1977, Volume: 36, Issue:2 Topics: Anticonvulsants; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Folic Acid; Humans; Phenytoin; Thymidine; Vitamin B 12	1977
Changes in serum immunoglobulin levels during phenytoin treatment of epilepsy. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:5 Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Male; Phenytoin; Vitamin B 12	1976
Folate and monoamine metabolism in epilepsy. Journal of the neurological sciences, 1975, Volume: 26, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Middle Aged; Phenobarbital; Phenytoin; Primidone; Vitamin B 12	1975
Effects of phenytoin sodium on doubling time, deoxyuridine suppression, 3H-methotrexate uptake and 57Co-cyanocobalamin uptake in HL60 cells. Clinical and laboratory haematology, 1990, Volume: 12, Issue:1 Topics: Cell Division; Cell Survival; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Methotrexate; Phenytoin; Tritium; Tumor Cells, Cultured; Vitamin B 12	1990
Folate metabolism and problem behaviour in mentally handicapped epileptics. Journal of mental deficiency research, 1987, Volume: 31 ( Pt 2) Topics: Adolescent; Adult; Aged; Epilepsy; Female; Folic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Middle Aged; Phenytoin; Vitamin B 12	1987
Cyanocabalamin and anticonvulsant-associated congenital defects. Lancet (London, England), 1973, Jun-23, Volume: 1, Issue:7817 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Female; Humans; Mice; Phenytoin; Pregnancy; Vitamin B 12	1973
Letter: Chelating agents and teratogenesis. Lancet (London, England), 1973, Oct-13, Volume: 2, Issue:7833 Topics: Abnormalities, Drug-Induced; Animals; Chelating Agents; Cortisone; Female; Haplorhini; Humans; Phenytoin; Pregnancy; Salicylates; Vitamin B 12	1973
Gastrointestinal function in anticonvulsant megaloblastic anaemia. Lancet (London, England), 1966, Jan-22, Volume: 1, Issue:7430 Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Intestinal Absorption; Phenobarbital; Phenytoin; Primidone; Vitamin B 12	1966
Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia. Lancet (London, England), 1968, Feb-24, Volume: 1, Issue:7539 Topics: Acetazolamide; Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone; Psychophysiologic Disorders; Thiazines; Vitamin B 12	1968
Folate studies in underprivileged children with epilepsy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Nov-24, Volume: 47, Issue:46 Topics: Anticonvulsants; Biological Assay; Child; Child, Preschool; Epilepsy; Euglena; Folic Acid; Hematocrit; Hemoglobins; Humans; Lacticaseibacillus casei; Leukocyte Count; Phenobarbital; Phenytoin; Primidone; Vitamin B 12	1973
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats. Acta medicinae Okayama, 1971, Volume: 25, Issue:5 Topics: Adolescent; Adult; Animals; Anticonvulsants; Cell Nucleus; Depression, Chemical; Epithelial Cells; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Iron; Kidney; Leukocyte Count; Liver; Male; Middle Aged; Mouth Mucosa; Neutrophils; Phenobarbital; Phenytoin; Primidone; Rats; Tritium; Vitamin B 12	1971
Neuropathy after alcohol withdrawal. Journal of neurology, neurosurgery, and psychiatry, 1972, Volume: 35, Issue:3 Topics: Adult; Alcoholism; Female; Folic Acid; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Phenytoin; Substance Withdrawal Syndrome; Vitamin B 12; Vitamin B Complex	1972
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation. Neurology, 1974, Volume: 24, Issue:5 Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked Potentials; Female; Folic Acid; Humans; Male; Median Nerve; Middle Aged; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Phenobarbital; Phenytoin; Primidone; Reaction Time; Reflex, Monosynaptic; Sural Nerve; Time Factors; Vitamin B 12	1974
Tic douloureux in Rochester, Minnesota, 1945-1969. Neurology, 1972, Volume: 22, Issue:9 Topics: Adult; Age Factors; Aged; Analgesics; Carbamazepine; Ethanol; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Minnesota; Multiple Sclerosis; Neoplasms; Phenytoin; Sex Factors; Trigeminal Neuralgia; Vitamin B 12	1972
Cerebrospinal fluid folate, and vitamin B 12 in anticonvulsant-induced megaloblastosis. The Journal of laboratory and clinical medicine, 1973, Volume: 81, Issue:1 Topics: Aged; Alcoholism; Anemia, Macrocytic; Anemia, Pernicious; Female; Folic Acid; Hematocrit; Hemoglobins; Humans; Male; Middle Aged; Phenytoin; Reticulocytes; Vitamin B 12	1973
Serum folic acid activity (L. casei) in Sephadex gel chromatography. Journal of clinical pathology, 1973, Volume: 26, Issue:7 Topics: Albumins; Anemia, Pernicious; Chromatography; Dextrans; Female; Folic Acid; Humans; Macroglobulins; Phenytoin; Pregnancy; Protein Binding; Transferrin; Vitamin B 12	1973
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics. The Tohoku journal of experimental medicine, 1973, Volume: 110, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Azo Compounds; Child; Epilepsy; Female; FIGLU Test; Folic Acid; Glutarates; Histidine; Humans; Intellectual Disability; Male; Neutrophils; Phenytoin; Vitamin B 12	1973
[Editorial: Antiepileptic agents--folic acid]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18 Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Vitamin B 12	1973
Mechanism of decrease in serum folate levels of rats receiving diphenylhydantoin. The Tohoku journal of experimental medicine, 1973, Volume: 111, Issue:3 Topics: Animals; Blood Proteins; Folic Acid; Liver; Male; Methionine; Methyltransferases; Phenytoin; Protein Binding; Rats; Tetrahydrofolates; Vitamin B 12	1973
Folate metabolism and anticonvulsant therapy. Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:1 Topics: Anticonvulsants; Blood-Brain Barrier; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primidone; Vitamin B 12	1974
Biochemical lesion in Dilantin-induced erythroid aplasia. Blood, 1967, Volume: 30, Issue:5 Topics: Adolescent; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Carbon Isotopes; DNA; Erythrocytes; Fluorescent Antibody Technique; Folic Acid; Formates; Glycine; Humans; In Vitro Techniques; Injections, Intravenous; Iron Isotopes; Male; Nucleosides; Phenytoin; Riboflavin; RNA; Tritium; Vitamin B 12	1967
[Megaloblastic anemia in children]. Nordisk medicin, 1971, Volume: 86, Issue:49 Topics: Adolescent; Anemia, Macrocytic; Blood Transfusion; Child; Female; Folic Acid; Humans; Intellectual Disability; Phenytoin; Vitamin B 12	1971
Folate metabolism in epileptic and psychiatric patients. Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:6 Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Aged; Phenobarbital; Phenothiazines; Phenytoin; Vitamin B 12	1971
CSF and serum folic acid and protein changes with diphenylhydantoin treatment: laboratory and clinical correlations. Neurology, 1970, Volume: 20, Issue:4 Topics: Aged; Blood Proteins; Cerebrospinal Fluid Proteins; Electroencephalography; Folic Acid; Folic Acid Deficiency; Humans; Middle Aged; Phenytoin; Potassium; Seizures; Sodium; Vitamin B 12	1970
Mental effects of anticonvulsants, and folic acid metabolism. Brain : a journal of neurology, 1968, Volume: 91, Issue:2 Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Mental Disorders; Peripheral Nerves; Phenobarbital; Phenytoin; Primidone; Psychotic Disorders; Sex Factors; Spinal Cord; Vitamin B 12	1968
Folic acid and anticonvulsive drugs. Archives of neurology, 1969, Volume: 21, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hematocrit; Humans; Male; Middle Aged; Neutrophils; Phenobarbital; Phenytoin; Primidone; Psychotic Disorders; Vitamin B 12	1969
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy. Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:3 Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorders; Phenobarbital; Phenytoin; Primidone; Valproic Acid; Vitamin B 12	1983
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia, 1999, Volume: 40, Issue:3 Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency	1999
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta neurologica Scandinavica, 2000, Volume: 101, Issue:4 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12	2000
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT THERAPY. The Practitioner, 1963, Volume: 191 Topics: Amobarbital; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Barbiturates; Epilepsy; Folic Acid; Humans; Metabolism; Phenobarbital; Phenytoin; Primidone; Toxicology; Vitamin B 12	1963
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY. Blood, 1964, Volume: 23 Topics: Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood Chemical Analysis; Enterococcus faecalis; Epilepsy; Folic Acid; Folic Acid Antagonists; Humans; Lactobacillus; Phenobarbital; Phenytoin; Primidone; Toxicology; Vitamin B 12	1964
IATROGENIC MEGALOBLASTIC ANAEMIA WITH NEUROLOGICAL COMPLICATIONS. Scottish medical journal, 1964, Volume: 9 Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Brain Diseases; Cysticercosis; Drug Therapy; Epilepsy; Folic Acid; Humans; Iatrogenic Disease; Phenobarbital; Phenytoin; Primidone; Spinal Cord; Toxicology; Vitamin B 12	1964
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6. Seizure, 2006, Volume: 15, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Pyridoxal Phosphate; Reference Values; Valproic Acid; Vitamin B 12	2006
Vitamin B₁₂ deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia. BMJ case reports, 2012, Sep-03, Volume: 2012 Topics: Aged; Anticonvulsants; Cerebral Ventricles; Diagnosis, Differential; Drug Substitution; Epilepsy, Generalized; Humans; Image Interpretation, Computer-Assisted; Infusions, Intravenous; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Neurologic Examination; Pancytopenia; Phenytoin; Recurrence; Vitamin B 12; Vitamin B 12 Deficiency	2012
Effect observation of anti epileptic drugs on serum folic acid and vitamin B12 of epileptic patients. Minerva medica, 2015, Volume: 106, Issue:4 Topics: Adult; Anticonvulsants; Biomarkers; Case-Control Studies; Drug Monitoring; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B Complex	2015
Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children. Clinical laboratory, 2017, Jul-01, Volume: 63, Issue:7 Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phenytoin; Vitamin B 12	2017
To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients. Scientific reports, 2021, 02-23, Volume: 11, Issue:1 Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Vitamin B 12	2021